Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PDE4B_HUMAN

For an explanation of this page, click here

PDE4B_HUMAN
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE4A_HUMAN
θ value	0 (rank : 1)	NC score	0.996221 (rank : 4)
Query Neighborhood Hits	65	Target Neighborhood Hits	73	Shared Neighborhood Hits	40
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
θ value	0 (rank : 2)	NC score	0.996109 (rank : 5)
Query Neighborhood Hits	65	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4B_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	65	Target Neighborhood Hits	65	Shared Neighborhood Hits	65
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_HUMAN
θ value	0 (rank : 4)	NC score	0.996426 (rank : 3)
Query Neighborhood Hits	65	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
θ value	0 (rank : 5)	NC score	0.996066 (rank : 6)
Query Neighborhood Hits	65	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4D_HUMAN
θ value	0 (rank : 6)	NC score	0.995957 (rank : 7)
Query Neighborhood Hits	65	Target Neighborhood Hits	122	Shared Neighborhood Hits	42
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4D_MOUSE
θ value	0 (rank : 7)	NC score	0.996582 (rank : 2)
Query Neighborhood Hits	65	Target Neighborhood Hits	98	Shared Neighborhood Hits	42
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE1A_HUMAN
θ value	1.07972e-61 (rank : 8)	NC score	0.934477 (rank : 14)
Query Neighborhood Hits	65	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1A_MOUSE
θ value	1.19377e-60 (rank : 9)	NC score	0.934696 (rank : 13)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1C_HUMAN
θ value	2.03627e-60 (rank : 10)	NC score	0.924173 (rank : 19)
Query Neighborhood Hits	65	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	5.92465e-60 (rank : 11)	NC score	0.923283 (rank : 20)
Query Neighborhood Hits	65	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE8A_HUMAN
θ value	3.84025e-59 (rank : 12)	NC score	0.926673 (rank : 16)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE1B_MOUSE
θ value	4.24587e-58 (rank : 13)	NC score	0.934729 (rank : 12)
Query Neighborhood Hits	65	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE8B_HUMAN
θ value	3.0428e-56 (rank : 14)	NC score	0.924870 (rank : 17)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE7B_HUMAN
θ value	3.974e-56 (rank : 15)	NC score	0.939653 (rank : 8)
Query Neighborhood Hits	65	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE1B_HUMAN
θ value	6.77864e-56 (rank : 16)	NC score	0.932984 (rank : 15)
Query Neighborhood Hits	65	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE7B_MOUSE
θ value	8.85319e-56 (rank : 17)	NC score	0.939608 (rank : 9)
Query Neighborhood Hits	65	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7A_HUMAN
θ value	8.28633e-54 (rank : 18)	NC score	0.937851 (rank : 10)
Query Neighborhood Hits	65	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE8A_MOUSE
θ value	7.75577e-52 (rank : 19)	NC score	0.921355 (rank : 21)
Query Neighborhood Hits	65	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE7A_MOUSE
θ value	1.11993e-50 (rank : 20)	NC score	0.937173 (rank : 11)
Query Neighborhood Hits	65	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE9A_MOUSE
θ value	1.41672e-45 (rank : 21)	NC score	0.924204 (rank : 18)
Query Neighborhood Hits	65	Target Neighborhood Hits	72	Shared Neighborhood Hits	40
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE3B_HUMAN
θ value	9.18288e-45 (rank : 22)	NC score	0.910538 (rank : 23)
Query Neighborhood Hits	65	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE9A_HUMAN
θ value	2.67181e-44 (rank : 23)	NC score	0.920494 (rank : 22)
Query Neighborhood Hits	65	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE3A_HUMAN
θ value	1.91475e-42 (rank : 24)	NC score	0.894942 (rank : 24)
Query Neighborhood Hits	65	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
θ value	4.71619e-41 (rank : 25)	NC score	0.892203 (rank : 25)
Query Neighborhood Hits	65	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE2A_MOUSE
θ value	5.22648e-32 (rank : 26)	NC score	0.848862 (rank : 26)
Query Neighborhood Hits	65	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
θ value	6.82597e-32 (rank : 27)	NC score	0.847969 (rank : 27)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_MOUSE
θ value	7.54701e-31 (rank : 28)	NC score	0.826382 (rank : 29)
Query Neighborhood Hits	65	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_HUMAN
θ value	9.8567e-31 (rank : 29)	NC score	0.826548 (rank : 28)
Query Neighborhood Hits	65	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE6B_HUMAN
θ value	2.42779e-29 (rank : 30)	NC score	0.792697 (rank : 36)
Query Neighborhood Hits	65	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
θ value	9.2256e-29 (rank : 31)	NC score	0.790728 (rank : 38)
Query Neighborhood Hits	65	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6C_MOUSE
θ value	9.2256e-29 (rank : 32)	NC score	0.798870 (rank : 33)
Query Neighborhood Hits	65	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
θ value	1.57365e-28 (rank : 33)	NC score	0.796795 (rank : 35)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6C_HUMAN
θ value	1.57365e-28 (rank : 34)	NC score	0.798275 (rank : 34)
Query Neighborhood Hits	65	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE5A_MOUSE
θ value	1.02001e-27 (rank : 35)	NC score	0.809748 (rank : 31)
Query Neighborhood Hits	65	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6A_MOUSE
θ value	3.87602e-27 (rank : 36)	NC score	0.792337 (rank : 37)
Query Neighborhood Hits	65	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE10_HUMAN
θ value	3.62785e-25 (rank : 37)	NC score	0.826282 (rank : 30)
Query Neighborhood Hits	65	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE5A_HUMAN
θ value	8.08199e-25 (rank : 38)	NC score	0.806081 (rank : 32)
Query Neighborhood Hits	65	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

TLE6_MOUSE
θ value	0.0961366 (rank : 39)	NC score	0.015522 (rank : 41)
Query Neighborhood Hits	65	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVB3	Gene names	Tle6, Grg6
Domain Architecture
Description	Transducin-like enhancer protein 6 (Groucho-related protein 6).

GCC2_HUMAN
θ value	0.279714 (rank : 40)	NC score	0.009781 (rank : 46)
Query Neighborhood Hits	65	Target Neighborhood Hits	1558	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
θ value	0.279714 (rank : 41)	NC score	0.009807 (rank : 45)
Query Neighborhood Hits	65	Target Neighborhood Hits	1559	Shared Neighborhood Hits	17
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

SMC4_MOUSE
θ value	0.62314 (rank : 42)	NC score	0.010481 (rank : 43)
Query Neighborhood Hits	65	Target Neighborhood Hits	830	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

SMC4_HUMAN
θ value	0.813845 (rank : 43)	NC score	0.012702 (rank : 42)
Query Neighborhood Hits	65	Target Neighborhood Hits	937	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

NHS_HUMAN
θ value	1.38821 (rank : 44)	NC score	0.029652 (rank : 39)
Query Neighborhood Hits	65	Target Neighborhood Hits	198	Shared Neighborhood Hits	5
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

TEX14_MOUSE
θ value	1.81305 (rank : 45)	NC score	-0.000232 (rank : 64)
Query Neighborhood Hits	65	Target Neighborhood Hits	1333	Shared Neighborhood Hits	6
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

CJ118_HUMAN
θ value	2.36792 (rank : 46)	NC score	0.003007 (rank : 60)
Query Neighborhood Hits	65	Target Neighborhood Hits	937	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

EVPL_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.005570 (rank : 55)
Query Neighborhood Hits	65	Target Neighborhood Hits	895	Shared Neighborhood Hits	11
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

EVPL_MOUSE
θ value	3.0926 (rank : 48)	NC score	0.005609 (rank : 53)
Query Neighborhood Hits	65	Target Neighborhood Hits	952	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

GLIS1_MOUSE
θ value	3.0926 (rank : 49)	NC score	-0.003699 (rank : 65)
Query Neighborhood Hits	65	Target Neighborhood Hits	751	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K1M4, Q6NZF6, Q8R4Z3	Gene names	Glis1, Gli5
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1) (Gli homologous protein 1) (GliH1).

POF1B_MOUSE
θ value	3.0926 (rank : 50)	NC score	0.017723 (rank : 40)
Query Neighborhood Hits	65	Target Neighborhood Hits	530	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

ANR11_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.000153 (rank : 63)
Query Neighborhood Hits	65	Target Neighborhood Hits	1289	Shared Neighborhood Hits	10
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

GCC2_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.006841 (rank : 52)
Query Neighborhood Hits	65	Target Neighborhood Hits	1619	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

PGM2_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.006988 (rank : 51)
Query Neighborhood Hits	65	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q96G03, Q53FP5, Q5QTR0, Q9H0P9, Q9NV22	Gene names	PGM2
Domain Architecture	No domain graphic available
Description	Phosphoglucomutase-2 (EC 5.4.2.2) (Glucose phosphomutase 2) (PGM 2).

TACC1_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.007476 (rank : 48)
Query Neighborhood Hits	65	Target Neighborhood Hits	597	Shared Neighborhood Hits	14
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

FZD6_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.002044 (rank : 61)
Query Neighborhood Hits	65	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	O60353, Q6P9C3	Gene names	FZD6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (hFz6).

P3H2_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.007234 (rank : 50)
Query Neighborhood Hits	65	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVL5, Q9NVI2	Gene names	LEPREL1, MLAT4, P3H2
Domain Architecture	No domain graphic available
Description	Prolyl 3-hydroxylase 2 precursor (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4).

P3H2_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.007248 (rank : 49)
Query Neighborhood Hits	65	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CG71, Q8C673	Gene names	Leprel1, P3h2
Domain Architecture	No domain graphic available
Description	Prolyl 3-hydroxylase 2 precursor (EC 1.14.11.7) (Leprecan-like protein 1).

URFB1_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.010107 (rank : 44)
Query Neighborhood Hits	65	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	Q6BDS2, Q9NXE0	Gene names	UHRF1BP1, C6orf107
Domain Architecture	No domain graphic available
Description	UHRF1-binding protein 1 (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) (ICBP90-binding protein 1).

GCP2_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.005363 (rank : 56)
Query Neighborhood Hits	65	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BSJ2, O43632	Gene names	TUBGCP2, GCP2
Domain Architecture
Description	Gamma-tubulin complex component 2 (GCP-2) (Spindle pole body protein Spc97 homolog) (hSpc97) (hGCP2) (h103p).

CX045_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.008159 (rank : 47)
Query Neighborhood Hits	65	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H5U8, Q5JXY9	Gene names	CXorf45
Domain Architecture	No domain graphic available
Description	Protein CXorf45.

EDRF1_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.005576 (rank : 54)
Query Neighborhood Hits	65	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q6GQV7, Q80ZY3, Q8R3P5	Gene names	Edrf1
Domain Architecture	No domain graphic available
Description	Erythroid differentiation-related factor 1.

MYH4_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.000696 (rank : 62)
Query Neighborhood Hits	65	Target Neighborhood Hits	1377	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

TACC1_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.005256 (rank : 57)
Query Neighborhood Hits	65	Target Neighborhood Hits	667	Shared Neighborhood Hits	13
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TIAM1_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.003274 (rank : 59)
Query Neighborhood Hits	65	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.003329 (rank : 58)
Query Neighborhood Hits	65	Target Neighborhood Hits	205	Shared Neighborhood Hits	3
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

Hits sorted by NC score

PDE4B_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	65	Target Neighborhood Hits	65	Shared Neighborhood Hits	65
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4D_MOUSE
NC score	0.996582 (rank : 2)	θ value	0 (rank : 7)
Query Neighborhood Hits	65	Target Neighborhood Hits	98	Shared Neighborhood Hits	42
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4C_HUMAN
NC score	0.996426 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	65	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4A_HUMAN
NC score	0.996221 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	65	Target Neighborhood Hits	73	Shared Neighborhood Hits	40
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
NC score	0.996109 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	65	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4C_MOUSE
NC score	0.996066 (rank : 6)	θ value	0 (rank : 5)
Query Neighborhood Hits	65	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4D_HUMAN
NC score	0.995957 (rank : 7)	θ value	0 (rank : 6)
Query Neighborhood Hits	65	Target Neighborhood Hits	122	Shared Neighborhood Hits	42
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE7B_HUMAN
NC score	0.939653 (rank : 8)	θ value	3.974e-56 (rank : 15)
Query Neighborhood Hits	65	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_MOUSE
NC score	0.939608 (rank : 9)	θ value	8.85319e-56 (rank : 17)
Query Neighborhood Hits	65	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7A_HUMAN
NC score	0.937851 (rank : 10)	θ value	8.28633e-54 (rank : 18)
Query Neighborhood Hits	65	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
NC score	0.937173 (rank : 11)	θ value	1.11993e-50 (rank : 20)
Query Neighborhood Hits	65	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE1B_MOUSE
NC score	0.934729 (rank : 12)	θ value	4.24587e-58 (rank : 13)
Query Neighborhood Hits	65	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_MOUSE
NC score	0.934696 (rank : 13)	θ value	1.19377e-60 (rank : 9)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.934477 (rank : 14)	θ value	1.07972e-61 (rank : 8)
Query Neighborhood Hits	65	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1B_HUMAN
NC score	0.932984 (rank : 15)	θ value	6.77864e-56 (rank : 16)
Query Neighborhood Hits	65	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE8A_HUMAN
NC score	0.926673 (rank : 16)	θ value	3.84025e-59 (rank : 12)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE8B_HUMAN
NC score	0.924870 (rank : 17)	θ value	3.0428e-56 (rank : 14)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE9A_MOUSE
NC score	0.924204 (rank : 18)	θ value	1.41672e-45 (rank : 21)
Query Neighborhood Hits	65	Target Neighborhood Hits	72	Shared Neighborhood Hits	40
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE1C_HUMAN
NC score	0.924173 (rank : 19)	θ value	2.03627e-60 (rank : 10)
Query Neighborhood Hits	65	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
NC score	0.923283 (rank : 20)	θ value	5.92465e-60 (rank : 11)
Query Neighborhood Hits	65	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE8A_MOUSE
NC score	0.921355 (rank : 21)	θ value	7.75577e-52 (rank : 19)
Query Neighborhood Hits	65	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE9A_HUMAN
NC score	0.920494 (rank : 22)	θ value	2.67181e-44 (rank : 23)
Query Neighborhood Hits	65	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE3B_HUMAN
NC score	0.910538 (rank : 23)	θ value	9.18288e-45 (rank : 22)
Query Neighborhood Hits	65	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_HUMAN
NC score	0.894942 (rank : 24)	θ value	1.91475e-42 (rank : 24)
Query Neighborhood Hits	65	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
NC score	0.892203 (rank : 25)	θ value	4.71619e-41 (rank : 25)
Query Neighborhood Hits	65	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE2A_MOUSE
NC score	0.848862 (rank : 26)	θ value	5.22648e-32 (rank : 26)
Query Neighborhood Hits	65	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.847969 (rank : 27)	θ value	6.82597e-32 (rank : 27)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.826548 (rank : 28)	θ value	9.8567e-31 (rank : 29)
Query Neighborhood Hits	65	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.826382 (rank : 29)	θ value	7.54701e-31 (rank : 28)
Query Neighborhood Hits	65	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE10_HUMAN
NC score	0.826282 (rank : 30)	θ value	3.62785e-25 (rank : 37)
Query Neighborhood Hits	65	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE5A_MOUSE
NC score	0.809748 (rank : 31)	θ value	1.02001e-27 (rank : 35)
Query Neighborhood Hits	65	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.806081 (rank : 32)	θ value	8.08199e-25 (rank : 38)
Query Neighborhood Hits	65	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_MOUSE
NC score	0.798870 (rank : 33)	θ value	9.2256e-29 (rank : 32)
Query Neighborhood Hits	65	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
NC score	0.798275 (rank : 34)	θ value	1.57365e-28 (rank : 34)
Query Neighborhood Hits	65	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.796795 (rank : 35)	θ value	1.57365e-28 (rank : 33)
Query Neighborhood Hits	65	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6B_HUMAN
NC score	0.792697 (rank : 36)	θ value	2.42779e-29 (rank : 30)
Query Neighborhood Hits	65	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_MOUSE
NC score	0.792337 (rank : 37)	θ value	3.87602e-27 (rank : 36)
Query Neighborhood Hits	65	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_MOUSE
NC score	0.790728 (rank : 38)	θ value	9.2256e-29 (rank : 31)
Query Neighborhood Hits	65	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

NHS_HUMAN
NC score	0.029652 (rank : 39)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	65	Target Neighborhood Hits	198	Shared Neighborhood Hits	5
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

POF1B_MOUSE
NC score	0.017723 (rank : 40)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	65	Target Neighborhood Hits	530	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

TLE6_MOUSE
NC score	0.015522 (rank : 41)	θ value	0.0961366 (rank : 39)
Query Neighborhood Hits	65	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVB3	Gene names	Tle6, Grg6
Domain Architecture
Description	Transducin-like enhancer protein 6 (Groucho-related protein 6).

SMC4_HUMAN
NC score	0.012702 (rank : 42)	θ value	0.813845 (rank : 43)
Query Neighborhood Hits	65	Target Neighborhood Hits	937	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

SMC4_MOUSE
NC score	0.010481 (rank : 43)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	65	Target Neighborhood Hits	830	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

URFB1_HUMAN
NC score	0.010107 (rank : 44)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	65	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	Q6BDS2, Q9NXE0	Gene names	UHRF1BP1, C6orf107
Domain Architecture	No domain graphic available
Description	UHRF1-binding protein 1 (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) (ICBP90-binding protein 1).

RBP24_HUMAN
NC score	0.009807 (rank : 45)	θ value	0.279714 (rank : 41)
Query Neighborhood Hits	65	Target Neighborhood Hits	1559	Shared Neighborhood Hits	17
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.009781 (rank : 46)	θ value	0.279714 (rank : 40)
Query Neighborhood Hits	65	Target Neighborhood Hits	1558	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

CX045_HUMAN
NC score	0.008159 (rank : 47)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	65	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H5U8, Q5JXY9	Gene names	CXorf45
Domain Architecture	No domain graphic available
Description	Protein CXorf45.

TACC1_HUMAN
NC score	0.007476 (rank : 48)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	65	Target Neighborhood Hits	597	Shared Neighborhood Hits	14
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

P3H2_MOUSE
NC score	0.007248 (rank : 49)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	65	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CG71, Q8C673	Gene names	Leprel1, P3h2
Domain Architecture	No domain graphic available
Description	Prolyl 3-hydroxylase 2 precursor (EC 1.14.11.7) (Leprecan-like protein 1).

P3H2_HUMAN
NC score	0.007234 (rank : 50)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	65	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVL5, Q9NVI2	Gene names	LEPREL1, MLAT4, P3H2
Domain Architecture	No domain graphic available
Description	Prolyl 3-hydroxylase 2 precursor (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4).

PGM2_HUMAN
NC score	0.006988 (rank : 51)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	65	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q96G03, Q53FP5, Q5QTR0, Q9H0P9, Q9NV22	Gene names	PGM2
Domain Architecture	No domain graphic available
Description	Phosphoglucomutase-2 (EC 5.4.2.2) (Glucose phosphomutase 2) (PGM 2).

GCC2_MOUSE
NC score	0.006841 (rank : 52)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	65	Target Neighborhood Hits	1619	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

EVPL_MOUSE
NC score	0.005609 (rank : 53)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	65	Target Neighborhood Hits	952	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

EDRF1_MOUSE
NC score	0.005576 (rank : 54)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	65	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q6GQV7, Q80ZY3, Q8R3P5	Gene names	Edrf1
Domain Architecture	No domain graphic available
Description	Erythroid differentiation-related factor 1.

EVPL_HUMAN
NC score	0.005570 (rank : 55)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	65	Target Neighborhood Hits	895	Shared Neighborhood Hits	11
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

GCP2_HUMAN
NC score	0.005363 (rank : 56)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	65	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BSJ2, O43632	Gene names	TUBGCP2, GCP2
Domain Architecture
Description	Gamma-tubulin complex component 2 (GCP-2) (Spindle pole body protein Spc97 homolog) (hSpc97) (hGCP2) (h103p).

TACC1_MOUSE
NC score	0.005256 (rank : 57)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	65	Target Neighborhood Hits	667	Shared Neighborhood Hits	13
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TIAM1_MOUSE
NC score	0.003329 (rank : 58)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	65	Target Neighborhood Hits	205	Shared Neighborhood Hits	3
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.003274 (rank : 59)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	65	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CJ118_HUMAN
NC score	0.003007 (rank : 60)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	65	Target Neighborhood Hits	937	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

FZD6_HUMAN
NC score	0.002044 (rank : 61)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	65	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	O60353, Q6P9C3	Gene names	FZD6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (hFz6).

MYH4_HUMAN
NC score	0.000696 (rank : 62)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	65	Target Neighborhood Hits	1377	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

ANR11_HUMAN
NC score	0.000153 (rank : 63)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	65	Target Neighborhood Hits	1289	Shared Neighborhood Hits	10
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

TEX14_MOUSE
NC score	-0.000232 (rank : 64)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	65	Target Neighborhood Hits	1333	Shared Neighborhood Hits	6
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

GLIS1_MOUSE
NC score	-0.003699 (rank : 65)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	65	Target Neighborhood Hits	751	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K1M4, Q6NZF6, Q8R4Z3	Gene names	Glis1, Gli5
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1) (Gli homologous protein 1) (GliH1).