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Network neighborhood for query Sequence : PDE3B_HUMAN

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PDE3B_HUMAN
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE3A_HUMAN
θ value	0 (rank : 1)	NC score	0.986246 (rank : 2)
Query Neighborhood Hits	60	Target Neighborhood Hits	79	Shared Neighborhood Hits	39
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
θ value	0 (rank : 2)	NC score	0.983104 (rank : 3)
Query Neighborhood Hits	60	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3B_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	60	Target Neighborhood Hits	60	Shared Neighborhood Hits	60
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE4D_HUMAN
θ value	4.40402e-47 (rank : 4)	NC score	0.907800 (rank : 15)
Query Neighborhood Hits	60	Target Neighborhood Hits	122	Shared Neighborhood Hits	40
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4D_MOUSE
θ value	5.7518e-47 (rank : 5)	NC score	0.908602 (rank : 13)
Query Neighborhood Hits	60	Target Neighborhood Hits	98	Shared Neighborhood Hits	40
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_MOUSE
θ value	2.18568e-46 (rank : 6)	NC score	0.908990 (rank : 12)
Query Neighborhood Hits	60	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE1A_MOUSE
θ value	2.85459e-46 (rank : 7)	NC score	0.922396 (rank : 4)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1A_HUMAN
θ value	4.86918e-46 (rank : 8)	NC score	0.921867 (rank : 5)
Query Neighborhood Hits	60	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1C_HUMAN
θ value	5.38352e-45 (rank : 9)	NC score	0.912426 (rank : 8)
Query Neighborhood Hits	60	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	7.03111e-45 (rank : 10)	NC score	0.912164 (rank : 9)
Query Neighborhood Hits	60	Target Neighborhood Hits	161	Shared Neighborhood Hits	39
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE4B_HUMAN
θ value	9.18288e-45 (rank : 11)	NC score	0.910538 (rank : 11)
Query Neighborhood Hits	60	Target Neighborhood Hits	65	Shared Neighborhood Hits	39
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4A_HUMAN
θ value	1.56636e-44 (rank : 12)	NC score	0.907912 (rank : 14)
Query Neighborhood Hits	60	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4C_MOUSE
θ value	2.95404e-43 (rank : 13)	NC score	0.910547 (rank : 10)
Query Neighborhood Hits	60	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE1B_MOUSE
θ value	7.27602e-42 (rank : 14)	NC score	0.919110 (rank : 6)
Query Neighborhood Hits	60	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1B_HUMAN
θ value	2.11701e-41 (rank : 15)	NC score	0.917971 (rank : 7)
Query Neighborhood Hits	60	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE4C_HUMAN
θ value	2.76489e-41 (rank : 16)	NC score	0.907319 (rank : 16)
Query Neighborhood Hits	60	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE8B_HUMAN
θ value	5.96599e-36 (rank : 17)	NC score	0.898924 (rank : 19)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE8A_MOUSE
θ value	2.96089e-35 (rank : 18)	NC score	0.896094 (rank : 23)
Query Neighborhood Hits	60	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE8A_HUMAN
θ value	3.27365e-34 (rank : 19)	NC score	0.896341 (rank : 21)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE7A_MOUSE
θ value	1.24399e-33 (rank : 20)	NC score	0.903333 (rank : 17)
Query Neighborhood Hits	60	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE7A_HUMAN
θ value	3.61944e-33 (rank : 21)	NC score	0.902405 (rank : 18)
Query Neighborhood Hits	60	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7B_MOUSE
θ value	1.6813e-30 (rank : 22)	NC score	0.898084 (rank : 20)
Query Neighborhood Hits	60	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_HUMAN
θ value	7.06379e-29 (rank : 23)	NC score	0.896098 (rank : 22)
Query Neighborhood Hits	60	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE9A_MOUSE
θ value	4.57862e-28 (rank : 24)	NC score	0.888910 (rank : 24)
Query Neighborhood Hits	60	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_HUMAN
θ value	2.96777e-27 (rank : 25)	NC score	0.884607 (rank : 25)
Query Neighborhood Hits	60	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE2A_MOUSE
θ value	2.20094e-22 (rank : 26)	NC score	0.804870 (rank : 26)
Query Neighborhood Hits	60	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
θ value	4.9032e-22 (rank : 27)	NC score	0.803874 (rank : 27)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
θ value	3.28887e-18 (rank : 28)	NC score	0.773969 (rank : 28)
Query Neighborhood Hits	60	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
θ value	3.28887e-18 (rank : 29)	NC score	0.773481 (rank : 29)
Query Neighborhood Hits	60	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE6C_MOUSE
θ value	3.76295e-14 (rank : 30)	NC score	0.734384 (rank : 33)
Query Neighborhood Hits	60	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
θ value	1.42992e-13 (rank : 31)	NC score	0.733459 (rank : 34)
Query Neighborhood Hits	60	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6B_HUMAN
θ value	9.26847e-13 (rank : 32)	NC score	0.723695 (rank : 36)
Query Neighborhood Hits	60	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE5A_HUMAN
θ value	2.69671e-12 (rank : 33)	NC score	0.741376 (rank : 32)
Query Neighborhood Hits	60	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6A_HUMAN
θ value	4.59992e-12 (rank : 34)	NC score	0.726965 (rank : 35)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6A_MOUSE
θ value	6.00763e-12 (rank : 35)	NC score	0.723154 (rank : 37)
Query Neighborhood Hits	60	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE5A_MOUSE
θ value	7.84624e-12 (rank : 36)	NC score	0.742986 (rank : 31)
Query Neighborhood Hits	60	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE10_HUMAN
θ value	1.02475e-11 (rank : 37)	NC score	0.762223 (rank : 30)
Query Neighborhood Hits	60	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE6B_MOUSE
θ value	1.74796e-11 (rank : 38)	NC score	0.719222 (rank : 38)
Query Neighborhood Hits	60	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

CD2L6_HUMAN
θ value	0.813845 (rank : 39)	NC score	-0.000950 (rank : 59)
Query Neighborhood Hits	60	Target Neighborhood Hits	844	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

RBCC1_HUMAN
θ value	1.38821 (rank : 40)	NC score	0.003434 (rank : 55)
Query Neighborhood Hits	60	Target Neighborhood Hits	1023	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

PDPK1_MOUSE
θ value	1.81305 (rank : 41)	NC score	-0.003042 (rank : 60)
Query Neighborhood Hits	60	Target Neighborhood Hits	852	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

TNR19_MOUSE
θ value	2.36792 (rank : 42)	NC score	0.012500 (rank : 44)
Query Neighborhood Hits	60	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLL3, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7	Gene names	Tnfrsf19, Taj, Troy
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19 precursor (Toxicity and JNK inducer) (TRADE).

LEO1_HUMAN
θ value	3.0926 (rank : 43)	NC score	0.013701 (rank : 42)
Query Neighborhood Hits	60	Target Neighborhood Hits	958	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

SMCA5_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.003982 (rank : 53)
Query Neighborhood Hits	60	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	O60264	Gene names	SMARCA5, SNF2H, WCRF135
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.1.-) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin A5) (Sucrose nonfermenting protein 2 homolog) (hSNF2H).

UBN1_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.016346 (rank : 40)
Query Neighborhood Hits	60	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

CALX_MOUSE
θ value	4.03905 (rank : 46)	NC score	0.013736 (rank : 41)
Query Neighborhood Hits	60	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	P35564	Gene names	Canx
Domain Architecture
Description	Calnexin precursor.

CK042_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.019868 (rank : 39)
Query Neighborhood Hits	60	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5U0	Gene names	C11orf42
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf42.

KIF11_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.001354 (rank : 57)
Query Neighborhood Hits	60	Target Neighborhood Hits	583	Shared Neighborhood Hits	6
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

LEO1_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.013508 (rank : 43)
Query Neighborhood Hits	60	Target Neighborhood Hits	946	Shared Neighborhood Hits	10
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

AKA10_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.009657 (rank : 45)
Query Neighborhood Hits	60	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	O43572, Q96AJ7	Gene names	AKAP10
Domain Architecture
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

CE152_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.000743 (rank : 58)
Query Neighborhood Hits	60	Target Neighborhood Hits	976	Shared Neighborhood Hits	6
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

PER1_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.008383 (rank : 48)
Query Neighborhood Hits	60	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.008454 (rank : 47)
Query Neighborhood Hits	60	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PKD2_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.005839 (rank : 50)
Query Neighborhood Hits	60	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

SNPC4_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.005042 (rank : 52)
Query Neighborhood Hits	60	Target Neighborhood Hits	589	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

OFD1_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.001675 (rank : 56)
Query Neighborhood Hits	60	Target Neighborhood Hits	753	Shared Neighborhood Hits	7
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

RFA1_MOUSE
θ value	6.88961 (rank : 57)	NC score	0.009319 (rank : 46)
Query Neighborhood Hits	60	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEE4, Q3TEJ8	Gene names	Rpa1
Domain Architecture	No domain graphic available
Description	Replication protein A 70 kDa DNA-binding subunit (RP-A) (RF-A) (Replication factor-A protein 1) (p70).

TACC1_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.003869 (rank : 54)
Query Neighborhood Hits	60	Target Neighborhood Hits	597	Shared Neighborhood Hits	6
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

EGLN_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.007465 (rank : 49)
Query Neighborhood Hits	60	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P17813, Q14248, Q14926	Gene names	ENG, END
Domain Architecture
Description	Endoglin precursor (CD105 antigen).

LRRF1_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.005173 (rank : 51)
Query Neighborhood Hits	60	Target Neighborhood Hits	625	Shared Neighborhood Hits	8
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

Hits sorted by NC score

PDE3B_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	60	Target Neighborhood Hits	60	Shared Neighborhood Hits	60
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_HUMAN
NC score	0.986246 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	60	Target Neighborhood Hits	79	Shared Neighborhood Hits	39
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
NC score	0.983104 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	60	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE1A_MOUSE
NC score	0.922396 (rank : 4)	θ value	2.85459e-46 (rank : 7)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.921867 (rank : 5)	θ value	4.86918e-46 (rank : 8)
Query Neighborhood Hits	60	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1B_MOUSE
NC score	0.919110 (rank : 6)	θ value	7.27602e-42 (rank : 14)
Query Neighborhood Hits	60	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1B_HUMAN
NC score	0.917971 (rank : 7)	θ value	2.11701e-41 (rank : 15)
Query Neighborhood Hits	60	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1C_HUMAN
NC score	0.912426 (rank : 8)	θ value	5.38352e-45 (rank : 9)
Query Neighborhood Hits	60	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
NC score	0.912164 (rank : 9)	θ value	7.03111e-45 (rank : 10)
Query Neighborhood Hits	60	Target Neighborhood Hits	161	Shared Neighborhood Hits	39
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE4C_MOUSE
NC score	0.910547 (rank : 10)	θ value	2.95404e-43 (rank : 13)
Query Neighborhood Hits	60	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4B_HUMAN
NC score	0.910538 (rank : 11)	θ value	9.18288e-45 (rank : 11)
Query Neighborhood Hits	60	Target Neighborhood Hits	65	Shared Neighborhood Hits	39
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4A_MOUSE
NC score	0.908990 (rank : 12)	θ value	2.18568e-46 (rank : 6)
Query Neighborhood Hits	60	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4D_MOUSE
NC score	0.908602 (rank : 13)	θ value	5.7518e-47 (rank : 5)
Query Neighborhood Hits	60	Target Neighborhood Hits	98	Shared Neighborhood Hits	40
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_HUMAN
NC score	0.907912 (rank : 14)	θ value	1.56636e-44 (rank : 12)
Query Neighborhood Hits	60	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4D_HUMAN
NC score	0.907800 (rank : 15)	θ value	4.40402e-47 (rank : 4)
Query Neighborhood Hits	60	Target Neighborhood Hits	122	Shared Neighborhood Hits	40
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4C_HUMAN
NC score	0.907319 (rank : 16)	θ value	2.76489e-41 (rank : 16)
Query Neighborhood Hits	60	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE7A_MOUSE
NC score	0.903333 (rank : 17)	θ value	1.24399e-33 (rank : 20)
Query Neighborhood Hits	60	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE7A_HUMAN
NC score	0.902405 (rank : 18)	θ value	3.61944e-33 (rank : 21)
Query Neighborhood Hits	60	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE8B_HUMAN
NC score	0.898924 (rank : 19)	θ value	5.96599e-36 (rank : 17)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE7B_MOUSE
NC score	0.898084 (rank : 20)	θ value	1.6813e-30 (rank : 22)
Query Neighborhood Hits	60	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE8A_HUMAN
NC score	0.896341 (rank : 21)	θ value	3.27365e-34 (rank : 19)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.896098 (rank : 22)	θ value	7.06379e-29 (rank : 23)
Query Neighborhood Hits	60	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE8A_MOUSE
NC score	0.896094 (rank : 23)	θ value	2.96089e-35 (rank : 18)
Query Neighborhood Hits	60	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE9A_MOUSE
NC score	0.888910 (rank : 24)	θ value	4.57862e-28 (rank : 24)
Query Neighborhood Hits	60	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_HUMAN
NC score	0.884607 (rank : 25)	θ value	2.96777e-27 (rank : 25)
Query Neighborhood Hits	60	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE2A_MOUSE
NC score	0.804870 (rank : 26)	θ value	2.20094e-22 (rank : 26)
Query Neighborhood Hits	60	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.803874 (rank : 27)	θ value	4.9032e-22 (rank : 27)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.773969 (rank : 28)	θ value	3.28887e-18 (rank : 28)
Query Neighborhood Hits	60	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.773481 (rank : 29)	θ value	3.28887e-18 (rank : 29)
Query Neighborhood Hits	60	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE10_HUMAN
NC score	0.762223 (rank : 30)	θ value	1.02475e-11 (rank : 37)
Query Neighborhood Hits	60	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE5A_MOUSE
NC score	0.742986 (rank : 31)	θ value	7.84624e-12 (rank : 36)
Query Neighborhood Hits	60	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.741376 (rank : 32)	θ value	2.69671e-12 (rank : 33)
Query Neighborhood Hits	60	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_MOUSE
NC score	0.734384 (rank : 33)	θ value	3.76295e-14 (rank : 30)
Query Neighborhood Hits	60	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
NC score	0.733459 (rank : 34)	θ value	1.42992e-13 (rank : 31)
Query Neighborhood Hits	60	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.726965 (rank : 35)	θ value	4.59992e-12 (rank : 34)
Query Neighborhood Hits	60	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6B_HUMAN
NC score	0.723695 (rank : 36)	θ value	9.26847e-13 (rank : 32)
Query Neighborhood Hits	60	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_MOUSE
NC score	0.723154 (rank : 37)	θ value	6.00763e-12 (rank : 35)
Query Neighborhood Hits	60	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_MOUSE
NC score	0.719222 (rank : 38)	θ value	1.74796e-11 (rank : 38)
Query Neighborhood Hits	60	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

CK042_HUMAN
NC score	0.019868 (rank : 39)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	60	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5U0	Gene names	C11orf42
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf42.

UBN1_HUMAN
NC score	0.016346 (rank : 40)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	60	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

CALX_MOUSE
NC score	0.013736 (rank : 41)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	60	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	P35564	Gene names	Canx
Domain Architecture
Description	Calnexin precursor.

LEO1_HUMAN
NC score	0.013701 (rank : 42)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	60	Target Neighborhood Hits	958	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

LEO1_MOUSE
NC score	0.013508 (rank : 43)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	60	Target Neighborhood Hits	946	Shared Neighborhood Hits	10
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

TNR19_MOUSE
NC score	0.012500 (rank : 44)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	60	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLL3, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7	Gene names	Tnfrsf19, Taj, Troy
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19 precursor (Toxicity and JNK inducer) (TRADE).

AKA10_HUMAN
NC score	0.009657 (rank : 45)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	60	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	O43572, Q96AJ7	Gene names	AKAP10
Domain Architecture
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

RFA1_MOUSE
NC score	0.009319 (rank : 46)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	60	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEE4, Q3TEJ8	Gene names	Rpa1
Domain Architecture	No domain graphic available
Description	Replication protein A 70 kDa DNA-binding subunit (RP-A) (RF-A) (Replication factor-A protein 1) (p70).

PER1_MOUSE
NC score	0.008454 (rank : 47)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	60	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER1_HUMAN
NC score	0.008383 (rank : 48)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	60	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

EGLN_HUMAN
NC score	0.007465 (rank : 49)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	60	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P17813, Q14248, Q14926	Gene names	ENG, END
Domain Architecture
Description	Endoglin precursor (CD105 antigen).

PKD2_MOUSE
NC score	0.005839 (rank : 50)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	60	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

LRRF1_HUMAN
NC score	0.005173 (rank : 51)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	60	Target Neighborhood Hits	625	Shared Neighborhood Hits	8
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

SNPC4_HUMAN
NC score	0.005042 (rank : 52)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	60	Target Neighborhood Hits	589	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SMCA5_HUMAN
NC score	0.003982 (rank : 53)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	60	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	O60264	Gene names	SMARCA5, SNF2H, WCRF135
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.1.-) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin A5) (Sucrose nonfermenting protein 2 homolog) (hSNF2H).

TACC1_HUMAN
NC score	0.003869 (rank : 54)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	60	Target Neighborhood Hits	597	Shared Neighborhood Hits	6
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

RBCC1_HUMAN
NC score	0.003434 (rank : 55)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	60	Target Neighborhood Hits	1023	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

OFD1_HUMAN
NC score	0.001675 (rank : 56)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	60	Target Neighborhood Hits	753	Shared Neighborhood Hits	7
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

KIF11_HUMAN
NC score	0.001354 (rank : 57)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	60	Target Neighborhood Hits	583	Shared Neighborhood Hits	6
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

CE152_HUMAN
NC score	0.000743 (rank : 58)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	60	Target Neighborhood Hits	976	Shared Neighborhood Hits	6
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CD2L6_HUMAN
NC score	-0.000950 (rank : 59)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	60	Target Neighborhood Hits	844	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

PDPK1_MOUSE
NC score	-0.003042 (rank : 60)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	60	Target Neighborhood Hits	852	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).