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Network neighborhood for query Sequence : PDE1B_HUMAN

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PDE1B_HUMAN
 
SwissProt Accessions Q01064, Q92825 Gene names PDE1B, PDE1B1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
Rank Plots


Hits sorted by θ


PDE1B_HUMAN
 
θ value 0 (rank : 1) NC score 0.999962 (rank : 1)
Query Neighborhood Hits 50 Target Neighborhood Hits 50 Shared Neighborhood Hits 50
SwissProt Accessions Q01064, Q92825 Gene names PDE1B, PDE1B1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
PDE1B_MOUSE
 
θ value 0 (rank : 2) NC score 0.999658 (rank : 2)
Query Neighborhood Hits 50 Target Neighborhood Hits 46 Shared Neighborhood Hits 44
SwissProt Accessions Q01065, O35384 Gene names Pde1b, Pde1b1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
PDE1C_MOUSE
 
θ value 5.35569e-178 (rank : 3) NC score 0.988049 (rank : 6)
Query Neighborhood Hits 50 Target Neighborhood Hits 161 Shared Neighborhood Hits 40
SwissProt Accessions Q64338, Q62045, Q8BSV6 Gene names Pde1c
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).
PDE1C_HUMAN
 
θ value 9.13544e-178 (rank : 4) NC score 0.988485 (rank : 5)
Query Neighborhood Hits 50 Target Neighborhood Hits 134 Shared Neighborhood Hits 39
SwissProt Accessions Q14123, Q14124 Gene names PDE1C
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).
PDE1A_HUMAN
 
θ value 2.93876e-176 (rank : 5) NC score 0.995607 (rank : 3)
Query Neighborhood Hits 50 Target Neighborhood Hits 42 Shared Neighborhood Hits 39
SwissProt Accessions P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3 Gene names PDE1A
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).
PDE1A_MOUSE
 
θ value 8.28183e-171 (rank : 6) NC score 0.995562 (rank : 4)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 39
SwissProt Accessions Q61481, O35388 Gene names Pde1a
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).
PDE4D_HUMAN
 
θ value 2.40537e-61 (rank : 7) NC score 0.932122 (rank : 12)
Query Neighborhood Hits 50 Target Neighborhood Hits 122 Shared Neighborhood Hits 38
SwissProt Accessions Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7 Gene names PDE4D
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).
PDE4D_MOUSE
 
θ value 2.40537e-61 (rank : 8) NC score 0.932782 (rank : 10)
Query Neighborhood Hits 50 Target Neighborhood Hits 98 Shared Neighborhood Hits 38
SwissProt Accessions Q01063, Q6TRH9, Q8C4Q7, Q8CG05 Gene names Pde4d
Domain
Architecture

No domain graphic available

Description cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).
PDE4C_HUMAN
 
θ value 2.03627e-60 (rank : 9) NC score 0.934884 (rank : 8)
Query Neighborhood Hits 50 Target Neighborhood Hits 56 Shared Neighborhood Hits 38
SwissProt Accessions Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6 Gene names PDE4C
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).
PDE4C_MOUSE
 
θ value 2.25136e-59 (rank : 10) NC score 0.937139 (rank : 7)
Query Neighborhood Hits 50 Target Neighborhood Hits 60 Shared Neighborhood Hits 38
SwissProt Accessions Q3UEI1, Q8K0P4 Gene names Pde4c
Domain
Architecture

No domain graphic available

Description cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).
PDE4A_MOUSE
 
θ value 3.974e-56 (rank : 11) NC score 0.931800 (rank : 14)
Query Neighborhood Hits 50 Target Neighborhood Hits 66 Shared Neighborhood Hits 38
SwissProt Accessions O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8 Gene names Pde4a
Domain
Architecture
Description cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).
PDE4B_HUMAN
 
θ value 6.77864e-56 (rank : 12) NC score 0.932984 (rank : 9)
Query Neighborhood Hits 50 Target Neighborhood Hits 65 Shared Neighborhood Hits 38
SwissProt Accessions Q07343, O15443 Gene names PDE4B
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).
PDE4A_HUMAN
 
θ value 2.84797e-54 (rank : 13) NC score 0.931209 (rank : 17)
Query Neighborhood Hits 50 Target Neighborhood Hits 73 Shared Neighborhood Hits 38
SwissProt Accessions P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3 Gene names PDE4A
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).
PDE7B_MOUSE
 
θ value 5.38352e-45 (rank : 14) NC score 0.932557 (rank : 11)
Query Neighborhood Hits 50 Target Neighborhood Hits 44 Shared Neighborhood Hits 38
SwissProt Accessions Q9QXQ1 Gene names Pde7b
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).
PDE7A_MOUSE
 
θ value 7.77379e-44 (rank : 15) NC score 0.932069 (rank : 13)
Query Neighborhood Hits 50 Target Neighborhood Hits 39 Shared Neighborhood Hits 38
SwissProt Accessions P70453, Q9ERB3 Gene names Pde7a
Domain
Architecture
Description High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).
PDE7A_HUMAN
 
θ value 1.32601e-43 (rank : 16) NC score 0.931544 (rank : 15)
Query Neighborhood Hits 50 Target Neighborhood Hits 41 Shared Neighborhood Hits 38
SwissProt Accessions Q13946, O15380 Gene names PDE7A
Domain
Architecture
Description High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).
PDE7B_HUMAN
 
θ value 2.26182e-43 (rank : 17) NC score 0.931336 (rank : 16)
Query Neighborhood Hits 50 Target Neighborhood Hits 43 Shared Neighborhood Hits 38
SwissProt Accessions Q9NP56 Gene names PDE7B
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).
PDE3A_MOUSE
 
θ value 7.27602e-42 (rank : 18) NC score 0.906620 (rank : 25)
Query Neighborhood Hits 50 Target Neighborhood Hits 115 Shared Neighborhood Hits 38
SwissProt Accessions Q9Z0X4 Gene names Pde3a
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
PDE3B_HUMAN
 
θ value 2.11701e-41 (rank : 19) NC score 0.917971 (rank : 19)
Query Neighborhood Hits 50 Target Neighborhood Hits 60 Shared Neighborhood Hits 38
SwissProt Accessions Q13370, O00639, Q14408 Gene names PDE3B
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).
PDE8A_HUMAN
 
θ value 1.3722e-40 (rank : 20) NC score 0.911115 (rank : 21)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7 Gene names PDE8A
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).
PDE3A_HUMAN
 
θ value 1.79215e-40 (rank : 21) NC score 0.907457 (rank : 24)
Query Neighborhood Hits 50 Target Neighborhood Hits 79 Shared Neighborhood Hits 38
SwissProt Accessions Q14432, O60865, Q13348 Gene names PDE3A
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
PDE9A_HUMAN
 
θ value 1.20211e-36 (rank : 22) NC score 0.914837 (rank : 20)
Query Neighborhood Hits 50 Target Neighborhood Hits 93 Shared Neighborhood Hits 41
SwissProt Accessions O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0 Gene names PDE9A
Domain
Architecture
Description High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
PDE8A_MOUSE
 
θ value 3.4976e-36 (rank : 23) NC score 0.908045 (rank : 22)
Query Neighborhood Hits 50 Target Neighborhood Hits 52 Shared Neighborhood Hits 38
SwissProt Accessions O88502 Gene names Pde8a, Pde8
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).
PDE8B_HUMAN
 
θ value 3.4976e-36 (rank : 24) NC score 0.907566 (rank : 23)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2 Gene names PDE8B
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).
PDE9A_MOUSE
 
θ value 3.4976e-36 (rank : 25) NC score 0.918136 (rank : 18)
Query Neighborhood Hits 50 Target Neighborhood Hits 72 Shared Neighborhood Hits 40
SwissProt Accessions O70628 Gene names Pde9a, Pde8b
Domain
Architecture
Description High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
PDE11_MOUSE
 
θ value 3.3877e-31 (rank : 26) NC score 0.828684 (rank : 28)
Query Neighborhood Hits 50 Target Neighborhood Hits 50 Shared Neighborhood Hits 39
SwissProt Accessions P0C1Q2 Gene names Pde11a
Domain
Architecture

No domain graphic available

Description Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).
PDE11_HUMAN
 
θ value 1.4233e-29 (rank : 27) NC score 0.828082 (rank : 29)
Query Neighborhood Hits 50 Target Neighborhood Hits 49 Shared Neighborhood Hits 39
SwissProt Accessions Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45 Gene names PDE11A
Domain
Architecture

No domain graphic available

Description Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).
PDE2A_HUMAN
 
θ value 3.28125e-26 (rank : 28) NC score 0.845881 (rank : 27)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O00408 Gene names PDE2A
Domain
Architecture
Description cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).
PDE6C_MOUSE
 
θ value 5.59698e-26 (rank : 29) NC score 0.797139 (rank : 33)
Query Neighborhood Hits 50 Target Neighborhood Hits 45 Shared Neighborhood Hits 38
SwissProt Accessions Q91ZQ1, Q8R0D4 Gene names Pde6c
Domain
Architecture

No domain graphic available

Description Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
PDE6C_HUMAN
 
θ value 9.54697e-26 (rank : 30) NC score 0.796338 (rank : 34)
Query Neighborhood Hits 50 Target Neighborhood Hits 56 Shared Neighborhood Hits 38
SwissProt Accessions P51160, Q5VY29 Gene names PDE6C, PDEA2
Domain
Architecture
Description Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
PDE2A_MOUSE
 
θ value 1.24688e-25 (rank : 31) NC score 0.846533 (rank : 26)
Query Neighborhood Hits 50 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q922S4, Q8K2U1 Gene names Pde2a
Domain
Architecture

No domain graphic available

Description cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).
PDE5A_MOUSE
 
θ value 4.01107e-24 (rank : 32) NC score 0.807823 (rank : 31)
Query Neighborhood Hits 50 Target Neighborhood Hits 50 Shared Neighborhood Hits 38
SwissProt Accessions Q8CG03 Gene names Pde5a, Pde5
Domain
Architecture
Description cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).
PDE6A_HUMAN
 
θ value 5.23862e-24 (rank : 33) NC score 0.791986 (rank : 35)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions P16499 Gene names PDE6A, PDEA
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).
PDE6A_MOUSE
 
θ value 2.59989e-23 (rank : 34) NC score 0.787569 (rank : 36)
Query Neighborhood Hits 50 Target Neighborhood Hits 45 Shared Neighborhood Hits 38
SwissProt Accessions P27664 Gene names Pde6a, Mpa, Pdea
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).
PDE6B_HUMAN
 
θ value 5.79196e-23 (rank : 35) NC score 0.786998 (rank : 37)
Query Neighborhood Hits 50 Target Neighborhood Hits 44 Shared Neighborhood Hits 38
SwissProt Accessions P35913, Q9BWH5 Gene names PDE6B, PDEB
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).
PDE6B_MOUSE
 
θ value 3.75424e-22 (rank : 36) NC score 0.784155 (rank : 38)
Query Neighborhood Hits 50 Target Neighborhood Hits 41 Shared Neighborhood Hits 38
SwissProt Accessions P23440 Gene names Pde6b, Mpb, Pdeb, rd
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).
PDE10_HUMAN
 
θ value 3.17815e-21 (rank : 37) NC score 0.822705 (rank : 30)
Query Neighborhood Hits 50 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q9Y233, Q9Y5T1 Gene names PDE10A
Domain
Architecture
Description cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).
PDE5A_HUMAN
 
θ value 2.5182e-18 (rank : 38) NC score 0.802296 (rank : 32)
Query Neighborhood Hits 50 Target Neighborhood Hits 48 Shared Neighborhood Hits 38
SwissProt Accessions O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6 Gene names PDE5A, PDE5
Domain
Architecture
Description cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).
GNRP_HUMAN
 
θ value 1.06291 (rank : 39) NC score 0.014509 (rank : 40)
Query Neighborhood Hits 50 Target Neighborhood Hits 239 Shared Neighborhood Hits 5
SwissProt Accessions Q13972, Q16027 Gene names RASGRF1, CDC25
Domain
Architecture
Description Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).
GNRP_MOUSE
 
θ value 1.81305 (rank : 40) NC score 0.023884 (rank : 39)
Query Neighborhood Hits 50 Target Neighborhood Hits 191 Shared Neighborhood Hits 8
SwissProt Accessions P27671 Gene names Rasgrf1, Cdc25, Grf1
Domain
Architecture
Description Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).
MYH11_MOUSE
 
θ value 1.81305 (rank : 41) NC score 0.000321 (rank : 47)
Query Neighborhood Hits 50 Target Neighborhood Hits 1777 Shared Neighborhood Hits 8
SwissProt Accessions O08638, O08639, Q62462, Q64195 Gene names Myh11
Domain
Architecture
Description Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).
F102B_HUMAN
 
θ value 3.0926 (rank : 42) NC score 0.012743 (rank : 42)
Query Neighborhood Hits 50 Target Neighborhood Hits 15 Shared Neighborhood Hits 2
SwissProt Accessions Q5T8I3, Q68DH7 Gene names FAM102B
Domain
Architecture

No domain graphic available

Description Protein FAM102B.
SEP11_MOUSE
 
θ value 3.0926 (rank : 43) NC score 0.004383 (rank : 44)
Query Neighborhood Hits 50 Target Neighborhood Hits 300 Shared Neighborhood Hits 5
SwissProt Accessions Q8C1B7, Q6P2K5, Q6P6I0 Gene names Sept11, D5Ertd606e
Domain
Architecture

No domain graphic available

Description Septin-11.
MYH11_HUMAN
 
θ value 4.03905 (rank : 44) NC score -0.001208 (rank : 50)
Query Neighborhood Hits 50 Target Neighborhood Hits 1806 Shared Neighborhood Hits 7
SwissProt Accessions P35749, O00396, O94944, P78422 Gene names MYH11, KIAA0866
Domain
Architecture
Description Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).
ANR18_HUMAN
 
θ value 5.27518 (rank : 45) NC score -0.000601 (rank : 49)
Query Neighborhood Hits 50 Target Neighborhood Hits 1106 Shared Neighborhood Hits 8
SwissProt Accessions Q8IVF6, Q7Z468 Gene names ANKRD18A, KIAA2015
Domain
Architecture
Description Ankyrin repeat domain-containing protein 18A.
MKL2_MOUSE
 
θ value 5.27518 (rank : 46) NC score 0.007226 (rank : 43)
Query Neighborhood Hits 50 Target Neighborhood Hits 269 Shared Neighborhood Hits 4
SwissProt Accessions P59759 Gene names Mkl2, Mrtfb
Domain
Architecture
Description MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).
MYH13_HUMAN
 
θ value 6.88961 (rank : 47) NC score -0.000017 (rank : 48)
Query Neighborhood Hits 50 Target Neighborhood Hits 1504 Shared Neighborhood Hits 12
SwissProt Accessions Q9UKX3, O95252 Gene names MYH13
Domain
Architecture
Description Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).
PRP17_MOUSE
 
θ value 6.88961 (rank : 48) NC score 0.002507 (rank : 46)
Query Neighborhood Hits 50 Target Neighborhood Hits 295 Shared Neighborhood Hits 3
SwissProt Accessions Q9DC48 Gene names Cdc40, Prp17
Domain
Architecture
Description Pre-mRNA-splicing factor PRP17 (Cell division cycle 40 homolog).
SEP11_HUMAN
 
θ value 6.88961 (rank : 49) NC score 0.003540 (rank : 45)
Query Neighborhood Hits 50 Target Neighborhood Hits 296 Shared Neighborhood Hits 5
SwissProt Accessions Q9NVA2, Q7L4N1 Gene names SEPT11
Domain
Architecture

No domain graphic available

Description Septin-11.
IFRD2_HUMAN
 
θ value 8.99809 (rank : 50) NC score 0.013272 (rank : 41)
Query Neighborhood Hits 50 Target Neighborhood Hits 10 Shared Neighborhood Hits 3
SwissProt Accessions Q12894 Gene names IFRD2
Domain
Architecture
Description Interferon-related developmental regulator 2 (SKMC15 protein).

Hits sorted by NC score


PDE1B_HUMAN
 
NC score 0.999962 (rank : 1) θ value 0 (rank : 1)
Query Neighborhood Hits 50 Target Neighborhood Hits 50 Shared Neighborhood Hits 50
SwissProt Accessions Q01064, Q92825 Gene names PDE1B, PDE1B1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
PDE1B_MOUSE
 
NC score 0.999658 (rank : 2) θ value 0 (rank : 2)
Query Neighborhood Hits 50 Target Neighborhood Hits 46 Shared Neighborhood Hits 44
SwissProt Accessions Q01065, O35384 Gene names Pde1b, Pde1b1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
PDE1A_HUMAN
 
NC score 0.995607 (rank : 3) θ value 2.93876e-176 (rank : 5)
Query Neighborhood Hits 50 Target Neighborhood Hits 42 Shared Neighborhood Hits 39
SwissProt Accessions P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3 Gene names PDE1A
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).
PDE1A_MOUSE
 
NC score 0.995562 (rank : 4) θ value 8.28183e-171 (rank : 6)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 39
SwissProt Accessions Q61481, O35388 Gene names Pde1a
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).
PDE1C_HUMAN
 
NC score 0.988485 (rank : 5) θ value 9.13544e-178 (rank : 4)
Query Neighborhood Hits 50 Target Neighborhood Hits 134 Shared Neighborhood Hits 39
SwissProt Accessions Q14123, Q14124 Gene names PDE1C
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).
PDE1C_MOUSE
 
NC score 0.988049 (rank : 6) θ value 5.35569e-178 (rank : 3)
Query Neighborhood Hits 50 Target Neighborhood Hits 161 Shared Neighborhood Hits 40
SwissProt Accessions Q64338, Q62045, Q8BSV6 Gene names Pde1c
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).
PDE4C_MOUSE
 
NC score 0.937139 (rank : 7) θ value 2.25136e-59 (rank : 10)
Query Neighborhood Hits 50 Target Neighborhood Hits 60 Shared Neighborhood Hits 38
SwissProt Accessions Q3UEI1, Q8K0P4 Gene names Pde4c
Domain
Architecture

No domain graphic available

Description cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).
PDE4C_HUMAN
 
NC score 0.934884 (rank : 8) θ value 2.03627e-60 (rank : 9)
Query Neighborhood Hits 50 Target Neighborhood Hits 56 Shared Neighborhood Hits 38
SwissProt Accessions Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6 Gene names PDE4C
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).
PDE4B_HUMAN
 
NC score 0.932984 (rank : 9) θ value 6.77864e-56 (rank : 12)
Query Neighborhood Hits 50 Target Neighborhood Hits 65 Shared Neighborhood Hits 38
SwissProt Accessions Q07343, O15443 Gene names PDE4B
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).
PDE4D_MOUSE
 
NC score 0.932782 (rank : 10) θ value 2.40537e-61 (rank : 8)
Query Neighborhood Hits 50 Target Neighborhood Hits 98 Shared Neighborhood Hits 38
SwissProt Accessions Q01063, Q6TRH9, Q8C4Q7, Q8CG05 Gene names Pde4d
Domain
Architecture

No domain graphic available

Description cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).
PDE7B_MOUSE
 
NC score 0.932557 (rank : 11) θ value 5.38352e-45 (rank : 14)
Query Neighborhood Hits 50 Target Neighborhood Hits 44 Shared Neighborhood Hits 38
SwissProt Accessions Q9QXQ1 Gene names Pde7b
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).
PDE4D_HUMAN
 
NC score 0.932122 (rank : 12) θ value 2.40537e-61 (rank : 7)
Query Neighborhood Hits 50 Target Neighborhood Hits 122 Shared Neighborhood Hits 38
SwissProt Accessions Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7 Gene names PDE4D
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).
PDE7A_MOUSE
 
NC score 0.932069 (rank : 13) θ value 7.77379e-44 (rank : 15)
Query Neighborhood Hits 50 Target Neighborhood Hits 39 Shared Neighborhood Hits 38
SwissProt Accessions P70453, Q9ERB3 Gene names Pde7a
Domain
Architecture
Description High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).
PDE4A_MOUSE
 
NC score 0.931800 (rank : 14) θ value 3.974e-56 (rank : 11)
Query Neighborhood Hits 50 Target Neighborhood Hits 66 Shared Neighborhood Hits 38
SwissProt Accessions O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8 Gene names Pde4a
Domain
Architecture
Description cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).
PDE7A_HUMAN
 
NC score 0.931544 (rank : 15) θ value 1.32601e-43 (rank : 16)
Query Neighborhood Hits 50 Target Neighborhood Hits 41 Shared Neighborhood Hits 38
SwissProt Accessions Q13946, O15380 Gene names PDE7A
Domain
Architecture
Description High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).
PDE7B_HUMAN
 
NC score 0.931336 (rank : 16) θ value 2.26182e-43 (rank : 17)
Query Neighborhood Hits 50 Target Neighborhood Hits 43 Shared Neighborhood Hits 38
SwissProt Accessions Q9NP56 Gene names PDE7B
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).
PDE4A_HUMAN
 
NC score 0.931209 (rank : 17) θ value 2.84797e-54 (rank : 13)
Query Neighborhood Hits 50 Target Neighborhood Hits 73 Shared Neighborhood Hits 38
SwissProt Accessions P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3 Gene names PDE4A
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).
PDE9A_MOUSE
 
NC score 0.918136 (rank : 18) θ value 3.4976e-36 (rank : 25)
Query Neighborhood Hits 50 Target Neighborhood Hits 72 Shared Neighborhood Hits 40
SwissProt Accessions O70628 Gene names Pde9a, Pde8b
Domain
Architecture
Description High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
PDE3B_HUMAN
 
NC score 0.917971 (rank : 19) θ value 2.11701e-41 (rank : 19)
Query Neighborhood Hits 50 Target Neighborhood Hits 60 Shared Neighborhood Hits 38
SwissProt Accessions Q13370, O00639, Q14408 Gene names PDE3B
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).
PDE9A_HUMAN
 
NC score 0.914837 (rank : 20) θ value 1.20211e-36 (rank : 22)
Query Neighborhood Hits 50 Target Neighborhood Hits 93 Shared Neighborhood Hits 41
SwissProt Accessions O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0 Gene names PDE9A
Domain
Architecture
Description High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
PDE8A_HUMAN
 
NC score 0.911115 (rank : 21) θ value 1.3722e-40 (rank : 20)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7 Gene names PDE8A
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).
PDE8A_MOUSE
 
NC score 0.908045 (rank : 22) θ value 3.4976e-36 (rank : 23)
Query Neighborhood Hits 50 Target Neighborhood Hits 52 Shared Neighborhood Hits 38
SwissProt Accessions O88502 Gene names Pde8a, Pde8
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).
PDE8B_HUMAN
 
NC score 0.907566 (rank : 23) θ value 3.4976e-36 (rank : 24)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2 Gene names PDE8B
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).
PDE3A_HUMAN
 
NC score 0.907457 (rank : 24) θ value 1.79215e-40 (rank : 21)
Query Neighborhood Hits 50 Target Neighborhood Hits 79 Shared Neighborhood Hits 38
SwissProt Accessions Q14432, O60865, Q13348 Gene names PDE3A
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
PDE3A_MOUSE
 
NC score 0.906620 (rank : 25) θ value 7.27602e-42 (rank : 18)
Query Neighborhood Hits 50 Target Neighborhood Hits 115 Shared Neighborhood Hits 38
SwissProt Accessions Q9Z0X4 Gene names Pde3a
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
PDE2A_MOUSE
 
NC score 0.846533 (rank : 26) θ value 1.24688e-25 (rank : 31)
Query Neighborhood Hits 50 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q922S4, Q8K2U1 Gene names Pde2a
Domain
Architecture

No domain graphic available

Description cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).
PDE2A_HUMAN
 
NC score 0.845881 (rank : 27) θ value 3.28125e-26 (rank : 28)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O00408 Gene names PDE2A
Domain
Architecture
Description cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).
PDE11_MOUSE
 
NC score 0.828684 (rank : 28) θ value 3.3877e-31 (rank : 26)
Query Neighborhood Hits 50 Target Neighborhood Hits 50 Shared Neighborhood Hits 39
SwissProt Accessions P0C1Q2 Gene names Pde11a
Domain
Architecture

No domain graphic available

Description Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).
PDE11_HUMAN
 
NC score 0.828082 (rank : 29) θ value 1.4233e-29 (rank : 27)
Query Neighborhood Hits 50 Target Neighborhood Hits 49 Shared Neighborhood Hits 39
SwissProt Accessions Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45 Gene names PDE11A
Domain
Architecture

No domain graphic available

Description Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).
PDE10_HUMAN
 
NC score 0.822705 (rank : 30) θ value 3.17815e-21 (rank : 37)
Query Neighborhood Hits 50 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q9Y233, Q9Y5T1 Gene names PDE10A
Domain
Architecture
Description cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).
PDE5A_MOUSE
 
NC score 0.807823 (rank : 31) θ value 4.01107e-24 (rank : 32)
Query Neighborhood Hits 50 Target Neighborhood Hits 50 Shared Neighborhood Hits 38
SwissProt Accessions Q8CG03 Gene names Pde5a, Pde5
Domain
Architecture
Description cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).
PDE5A_HUMAN
 
NC score 0.802296 (rank : 32) θ value 2.5182e-18 (rank : 38)
Query Neighborhood Hits 50 Target Neighborhood Hits 48 Shared Neighborhood Hits 38
SwissProt Accessions O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6 Gene names PDE5A, PDE5
Domain
Architecture
Description cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).
PDE6C_MOUSE
 
NC score 0.797139 (rank : 33) θ value 5.59698e-26 (rank : 29)
Query Neighborhood Hits 50 Target Neighborhood Hits 45 Shared Neighborhood Hits 38
SwissProt Accessions Q91ZQ1, Q8R0D4 Gene names Pde6c
Domain
Architecture

No domain graphic available

Description Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
PDE6C_HUMAN
 
NC score 0.796338 (rank : 34) θ value 9.54697e-26 (rank : 30)
Query Neighborhood Hits 50 Target Neighborhood Hits 56 Shared Neighborhood Hits 38
SwissProt Accessions P51160, Q5VY29 Gene names PDE6C, PDEA2
Domain
Architecture
Description Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
PDE6A_HUMAN
 
NC score 0.791986 (rank : 35) θ value 5.23862e-24 (rank : 33)
Query Neighborhood Hits 50 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions P16499 Gene names PDE6A, PDEA
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).
PDE6A_MOUSE
 
NC score 0.787569 (rank : 36) θ value 2.59989e-23 (rank : 34)
Query Neighborhood Hits 50 Target Neighborhood Hits 45 Shared Neighborhood Hits 38
SwissProt Accessions P27664 Gene names Pde6a, Mpa, Pdea
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).
PDE6B_HUMAN
 
NC score 0.786998 (rank : 37) θ value 5.79196e-23 (rank : 35)
Query Neighborhood Hits 50 Target Neighborhood Hits 44 Shared Neighborhood Hits 38
SwissProt Accessions P35913, Q9BWH5 Gene names PDE6B, PDEB
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).
PDE6B_MOUSE
 
NC score 0.784155 (rank : 38) θ value 3.75424e-22 (rank : 36)
Query Neighborhood Hits 50 Target Neighborhood Hits 41 Shared Neighborhood Hits 38
SwissProt Accessions P23440 Gene names Pde6b, Mpb, Pdeb, rd
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).
GNRP_MOUSE
 
NC score 0.023884 (rank : 39) θ value 1.81305 (rank : 40)
Query Neighborhood Hits 50 Target Neighborhood Hits 191 Shared Neighborhood Hits 8
SwissProt Accessions P27671 Gene names Rasgrf1, Cdc25, Grf1
Domain
Architecture
Description Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).
GNRP_HUMAN
 
NC score 0.014509 (rank : 40) θ value 1.06291 (rank : 39)
Query Neighborhood Hits 50 Target Neighborhood Hits 239 Shared Neighborhood Hits 5
SwissProt Accessions Q13972, Q16027 Gene names RASGRF1, CDC25
Domain
Architecture
Description Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).
IFRD2_HUMAN
 
NC score 0.013272 (rank : 41) θ value 8.99809 (rank : 50)
Query Neighborhood Hits 50 Target Neighborhood Hits 10 Shared Neighborhood Hits 3
SwissProt Accessions Q12894 Gene names IFRD2
Domain
Architecture
Description Interferon-related developmental regulator 2 (SKMC15 protein).
F102B_HUMAN
 
NC score 0.012743 (rank : 42) θ value 3.0926 (rank : 42)
Query Neighborhood Hits 50 Target Neighborhood Hits 15 Shared Neighborhood Hits 2
SwissProt Accessions Q5T8I3, Q68DH7 Gene names FAM102B
Domain
Architecture

No domain graphic available

Description Protein FAM102B.
MKL2_MOUSE
 
NC score 0.007226 (rank : 43) θ value 5.27518 (rank : 46)
Query Neighborhood Hits 50 Target Neighborhood Hits 269 Shared Neighborhood Hits 4
SwissProt Accessions P59759 Gene names Mkl2, Mrtfb
Domain
Architecture
Description MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).
SEP11_MOUSE
 
NC score 0.004383 (rank : 44) θ value 3.0926 (rank : 43)
Query Neighborhood Hits 50 Target Neighborhood Hits 300 Shared Neighborhood Hits 5
SwissProt Accessions Q8C1B7, Q6P2K5, Q6P6I0 Gene names Sept11, D5Ertd606e
Domain
Architecture

No domain graphic available

Description Septin-11.
SEP11_HUMAN
 
NC score 0.003540 (rank : 45) θ value 6.88961 (rank : 49)
Query Neighborhood Hits 50 Target Neighborhood Hits 296 Shared Neighborhood Hits 5
SwissProt Accessions Q9NVA2, Q7L4N1 Gene names SEPT11
Domain
Architecture

No domain graphic available

Description Septin-11.
PRP17_MOUSE
 
NC score 0.002507 (rank : 46) θ value 6.88961 (rank : 48)
Query Neighborhood Hits 50 Target Neighborhood Hits 295 Shared Neighborhood Hits 3
SwissProt Accessions Q9DC48 Gene names Cdc40, Prp17
Domain
Architecture
Description Pre-mRNA-splicing factor PRP17 (Cell division cycle 40 homolog).
MYH11_MOUSE
 
NC score 0.000321 (rank : 47) θ value 1.81305 (rank : 41)
Query Neighborhood Hits 50 Target Neighborhood Hits 1777 Shared Neighborhood Hits 8
SwissProt Accessions O08638, O08639, Q62462, Q64195 Gene names Myh11
Domain
Architecture
Description Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).
MYH13_HUMAN
 
NC score -0.000017 (rank : 48) θ value 6.88961 (rank : 47)
Query Neighborhood Hits 50 Target Neighborhood Hits 1504 Shared Neighborhood Hits 12
SwissProt Accessions Q9UKX3, O95252 Gene names MYH13
Domain
Architecture
Description Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).
ANR18_HUMAN
 
NC score -0.000601 (rank : 49) θ value 5.27518 (rank : 45)
Query Neighborhood Hits 50 Target Neighborhood Hits 1106 Shared Neighborhood Hits 8
SwissProt Accessions Q8IVF6, Q7Z468 Gene names ANKRD18A, KIAA2015
Domain
Architecture
Description Ankyrin repeat domain-containing protein 18A.
MYH11_HUMAN
 
NC score -0.001208 (rank : 50) θ value 4.03905 (rank : 44)
Query Neighborhood Hits 50 Target Neighborhood Hits 1806 Shared Neighborhood Hits 7
SwissProt Accessions P35749, O00396, O94944, P78422 Gene names MYH11, KIAA0866
Domain
Architecture
Description Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).