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Network neighborhood for query Sequence : GNRP_MOUSE

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GNRP_MOUSE
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GNRP_HUMAN
θ value	0 (rank : 1)	NC score	0.978944 (rank : 2)
Query Neighborhood Hits	191	Target Neighborhood Hits	239	Shared Neighborhood Hits	143
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	191
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_MOUSE
θ value	4.13158e-37 (rank : 3)	NC score	0.664183 (rank : 5)
Query Neighborhood Hits	191	Target Neighborhood Hits	281	Shared Neighborhood Hits	58
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
θ value	3.4976e-36 (rank : 4)	NC score	0.672810 (rank : 4)
Query Neighborhood Hits	191	Target Neighborhood Hits	274	Shared Neighborhood Hits	61
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
θ value	1.46948e-34 (rank : 5)	NC score	0.679141 (rank : 3)
Query Neighborhood Hits	191	Target Neighborhood Hits	193	Shared Neighborhood Hits	57
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

RPGF1_HUMAN
θ value	1.28732e-30 (rank : 6)	NC score	0.638569 (rank : 6)
Query Neighborhood Hits	191	Target Neighborhood Hits	262	Shared Neighborhood Hits	26
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RGL1_HUMAN
θ value	1.12775e-26 (rank : 7)	NC score	0.605110 (rank : 7)
Query Neighborhood Hits	191	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	3.28125e-26 (rank : 8)	NC score	0.593716 (rank : 8)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GRP3_HUMAN
θ value	5.59698e-26 (rank : 9)	NC score	0.518200 (rank : 24)
Query Neighborhood Hits	191	Target Neighborhood Hits	131	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GNDS_MOUSE
θ value	5.79196e-23 (rank : 10)	NC score	0.561990 (rank : 11)
Query Neighborhood Hits	191	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
θ value	9.87957e-23 (rank : 11)	NC score	0.551587 (rank : 17)
Query Neighborhood Hits	191	Target Neighborhood Hits	201	Shared Neighborhood Hits	23
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RPGF5_MOUSE
θ value	6.40375e-22 (rank : 12)	NC score	0.547499 (rank : 18)
Query Neighborhood Hits	191	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
θ value	1.2077e-20 (rank : 13)	NC score	0.555252 (rank : 15)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	23
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RGDSR_HUMAN
θ value	3.51386e-20 (rank : 14)	NC score	0.552781 (rank : 16)
Query Neighborhood Hits	191	Target Neighborhood Hits	63	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF4_HUMAN
θ value	2.97466e-19 (rank : 15)	NC score	0.508192 (rank : 27)
Query Neighborhood Hits	191	Target Neighborhood Hits	88	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RGL2_MOUSE
θ value	1.13037e-18 (rank : 16)	NC score	0.561646 (rank : 12)
Query Neighborhood Hits	191	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RPGF4_MOUSE
θ value	1.47631e-18 (rank : 17)	NC score	0.505199 (rank : 29)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RGL2_HUMAN
θ value	7.32683e-18 (rank : 18)	NC score	0.561442 (rank : 13)
Query Neighborhood Hits	191	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RPGF6_HUMAN
θ value	7.32683e-18 (rank : 19)	NC score	0.474947 (rank : 41)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF2_HUMAN
θ value	1.63225e-17 (rank : 20)	NC score	0.494331 (rank : 33)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

ABR_HUMAN
θ value	4.74913e-17 (rank : 21)	NC score	0.370394 (rank : 65)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
θ value	8.10077e-17 (rank : 22)	NC score	0.372991 (rank : 64)
Query Neighborhood Hits	191	Target Neighborhood Hits	204	Shared Neighborhood Hits	58
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

FGD2_MOUSE
θ value	1.52774e-15 (rank : 23)	NC score	0.506929 (rank : 28)
Query Neighborhood Hits	191	Target Neighborhood Hits	163	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

VAV2_HUMAN
θ value	7.58209e-15 (rank : 24)	NC score	0.395075 (rank : 55)
Query Neighborhood Hits	191	Target Neighborhood Hits	453	Shared Neighborhood Hits	65
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

RPGF3_MOUSE
θ value	1.68911e-14 (rank : 25)	NC score	0.458023 (rank : 50)
Query Neighborhood Hits	191	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF3_HUMAN
θ value	2.20605e-14 (rank : 26)	NC score	0.475604 (rank : 39)
Query Neighborhood Hits	191	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

ITSN2_HUMAN
θ value	6.41864e-14 (rank : 27)	NC score	0.348196 (rank : 70)
Query Neighborhood Hits	191	Target Neighborhood Hits	1173	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

FGD4_HUMAN
θ value	8.38298e-14 (rank : 28)	NC score	0.522744 (rank : 21)
Query Neighborhood Hits	191	Target Neighborhood Hits	219	Shared Neighborhood Hits	80
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_HUMAN
θ value	1.09485e-13 (rank : 29)	NC score	0.518647 (rank : 23)
Query Neighborhood Hits	191	Target Neighborhood Hits	151	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ITSN1_HUMAN
θ value	1.09485e-13 (rank : 30)	NC score	0.332900 (rank : 74)
Query Neighborhood Hits	191	Target Neighborhood Hits	1757	Shared Neighborhood Hits	100
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

FGD6_MOUSE
θ value	1.42992e-13 (rank : 31)	NC score	0.463039 (rank : 48)
Query Neighborhood Hits	191	Target Neighborhood Hits	282	Shared Neighborhood Hits	81
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ITSN1_MOUSE
θ value	1.86753e-13 (rank : 32)	NC score	0.334868 (rank : 73)
Query Neighborhood Hits	191	Target Neighborhood Hits	1669	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NGEF_MOUSE
θ value	1.86753e-13 (rank : 33)	NC score	0.510848 (rank : 26)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ECT2_MOUSE
θ value	3.18553e-13 (rank : 34)	NC score	0.564604 (rank : 10)
Query Neighborhood Hits	191	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ITSN2_MOUSE
θ value	7.09661e-13 (rank : 35)	NC score	0.331152 (rank : 75)
Query Neighborhood Hits	191	Target Neighborhood Hits	1371	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHGA_HUMAN
θ value	1.2105e-12 (rank : 36)	NC score	0.493519 (rank : 36)
Query Neighborhood Hits	191	Target Neighborhood Hits	187	Shared Neighborhood Hits	63
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

NGEF_HUMAN
θ value	1.2105e-12 (rank : 37)	NC score	0.524865 (rank : 20)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ECT2_HUMAN
θ value	1.58096e-12 (rank : 38)	NC score	0.559022 (rank : 14)
Query Neighborhood Hits	191	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD6_HUMAN
θ value	3.52202e-12 (rank : 39)	NC score	0.455597 (rank : 51)
Query Neighborhood Hits	191	Target Neighborhood Hits	237	Shared Neighborhood Hits	86
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

VAV2_MOUSE
θ value	4.59992e-12 (rank : 40)	NC score	0.393291 (rank : 56)
Query Neighborhood Hits	191	Target Neighborhood Hits	456	Shared Neighborhood Hits	66
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FGD4_MOUSE
θ value	6.00763e-12 (rank : 41)	NC score	0.519215 (rank : 22)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FARP2_HUMAN
θ value	1.02475e-11 (rank : 42)	NC score	0.349727 (rank : 69)
Query Neighborhood Hits	191	Target Neighborhood Hits	240	Shared Neighborhood Hits	84
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGA_MOUSE
θ value	2.28291e-11 (rank : 43)	NC score	0.491888 (rank : 37)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	58
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD3_HUMAN
θ value	2.98157e-11 (rank : 44)	NC score	0.511716 (rank : 25)
Query Neighborhood Hits	191	Target Neighborhood Hits	249	Shared Neighborhood Hits	61
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	2.98157e-11 (rank : 45)	NC score	0.527205 (rank : 19)
Query Neighborhood Hits	191	Target Neighborhood Hits	257	Shared Neighborhood Hits	76
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FARP2_MOUSE
θ value	5.08577e-11 (rank : 46)	NC score	0.386464 (rank : 57)
Query Neighborhood Hits	191	Target Neighborhood Hits	209	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD1_MOUSE
θ value	6.64225e-11 (rank : 47)	NC score	0.493527 (rank : 35)
Query Neighborhood Hits	191	Target Neighborhood Hits	387	Shared Neighborhood Hits	75
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
θ value	1.133e-10 (rank : 48)	NC score	0.494212 (rank : 34)
Query Neighborhood Hits	191	Target Neighborhood Hits	367	Shared Neighborhood Hits	75
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG5_HUMAN
θ value	2.52405e-10 (rank : 49)	NC score	0.501098 (rank : 30)
Query Neighborhood Hits	191	Target Neighborhood Hits	172	Shared Neighborhood Hits	59
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

RGNEF_MOUSE
θ value	5.62301e-10 (rank : 50)	NC score	0.329890 (rank : 76)
Query Neighborhood Hits	191	Target Neighborhood Hits	641	Shared Neighborhood Hits	72
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHGF_HUMAN
θ value	2.79066e-09 (rank : 51)	NC score	0.454967 (rank : 52)
Query Neighborhood Hits	191	Target Neighborhood Hits	214	Shared Neighborhood Hits	55
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PREX1_HUMAN
θ value	3.64472e-09 (rank : 52)	NC score	0.573249 (rank : 9)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

DNMBP_MOUSE
θ value	6.21693e-09 (rank : 53)	NC score	0.381675 (rank : 59)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	62
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG3_HUMAN
θ value	1.06045e-08 (rank : 54)	NC score	0.470865 (rank : 44)
Query Neighborhood Hits	191	Target Neighborhood Hits	82	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	1.06045e-08 (rank : 55)	NC score	0.470414 (rank : 45)
Query Neighborhood Hits	191	Target Neighborhood Hits	85	Shared Neighborhood Hits	55
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_MOUSE
θ value	1.38499e-08 (rank : 56)	NC score	0.496420 (rank : 31)
Query Neighborhood Hits	191	Target Neighborhood Hits	185	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
θ value	2.36244e-08 (rank : 57)	NC score	0.496149 (rank : 32)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TIAM1_HUMAN
θ value	2.36244e-08 (rank : 58)	NC score	0.463788 (rank : 47)
Query Neighborhood Hits	191	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHGG_MOUSE
θ value	3.08544e-08 (rank : 59)	NC score	0.483338 (rank : 38)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	58
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

TIAM1_MOUSE
θ value	4.0297e-08 (rank : 60)	NC score	0.465845 (rank : 46)
Query Neighborhood Hits	191	Target Neighborhood Hits	205	Shared Neighborhood Hits	73
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV_HUMAN
θ value	6.87365e-08 (rank : 61)	NC score	0.355938 (rank : 67)
Query Neighborhood Hits	191	Target Neighborhood Hits	452	Shared Neighborhood Hits	64
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

FARP1_HUMAN
θ value	1.17247e-07 (rank : 62)	NC score	0.323688 (rank : 78)
Query Neighborhood Hits	191	Target Neighborhood Hits	241	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

VAV3_MOUSE
θ value	2.61198e-07 (rank : 63)	NC score	0.380613 (rank : 61)
Query Neighborhood Hits	191	Target Neighborhood Hits	404	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHGG_HUMAN
θ value	9.92553e-07 (rank : 64)	NC score	0.475221 (rank : 40)
Query Neighborhood Hits	191	Target Neighborhood Hits	129	Shared Neighborhood Hits	58
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

VAV_MOUSE
θ value	9.92553e-07 (rank : 65)	NC score	0.362042 (rank : 66)
Query Neighborhood Hits	191	Target Neighborhood Hits	430	Shared Neighborhood Hits	63
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG8_HUMAN
θ value	1.29631e-06 (rank : 66)	NC score	0.459781 (rank : 49)
Query Neighborhood Hits	191	Target Neighborhood Hits	85	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG7_HUMAN
θ value	1.69304e-06 (rank : 67)	NC score	0.384919 (rank : 58)
Query Neighborhood Hits	191	Target Neighborhood Hits	347	Shared Neighborhood Hits	68
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHGB_HUMAN
θ value	1.69304e-06 (rank : 68)	NC score	0.380003 (rank : 62)
Query Neighborhood Hits	191	Target Neighborhood Hits	375	Shared Neighborhood Hits	65
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG8_MOUSE
θ value	2.21117e-06 (rank : 69)	NC score	0.431293 (rank : 54)
Query Neighborhood Hits	191	Target Neighborhood Hits	79	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG7_MOUSE
θ value	2.88788e-06 (rank : 70)	NC score	0.380735 (rank : 60)
Query Neighborhood Hits	191	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV3_HUMAN
θ value	2.88788e-06 (rank : 71)	NC score	0.373526 (rank : 63)
Query Neighborhood Hits	191	Target Neighborhood Hits	398	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG9_MOUSE
θ value	4.92598e-06 (rank : 72)	NC score	0.473942 (rank : 43)
Query Neighborhood Hits	191	Target Neighborhood Hits	234	Shared Neighborhood Hits	62
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
θ value	6.43352e-06 (rank : 73)	NC score	0.474302 (rank : 42)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	62
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

SWP70_HUMAN
θ value	1.43324e-05 (rank : 74)	NC score	0.131992 (rank : 114)
Query Neighborhood Hits	191	Target Neighborhood Hits	973	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	2.44474e-05 (rank : 75)	NC score	0.126984 (rank : 116)
Query Neighborhood Hits	191	Target Neighborhood Hits	1097	Shared Neighborhood Hits	84
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

DNMBP_HUMAN
θ value	0.000121331 (rank : 76)	NC score	0.350517 (rank : 68)
Query Neighborhood Hits	191	Target Neighborhood Hits	413	Shared Neighborhood Hits	65
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DAPP1_MOUSE
θ value	0.00035302 (rank : 77)	NC score	0.139657 (rank : 110)
Query Neighborhood Hits	191	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
θ value	0.000461057 (rank : 78)	NC score	0.138244 (rank : 112)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ARHG6_HUMAN
θ value	0.000602161 (rank : 79)	NC score	0.339562 (rank : 72)
Query Neighborhood Hits	191	Target Neighborhood Hits	376	Shared Neighborhood Hits	62
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CYH4_HUMAN
θ value	0.000602161 (rank : 80)	NC score	0.158436 (rank : 95)
Query Neighborhood Hits	191	Target Neighborhood Hits	135	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	0.000602161 (rank : 81)	NC score	0.157440 (rank : 98)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	51
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DUET_HUMAN
θ value	0.000602161 (rank : 82)	NC score	0.129826 (rank : 115)
Query Neighborhood Hits	191	Target Neighborhood Hits	1220	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHG6_MOUSE
θ value	0.00175202 (rank : 83)	NC score	0.323648 (rank : 79)
Query Neighborhood Hits	191	Target Neighborhood Hits	394	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CYH3_MOUSE
θ value	0.00175202 (rank : 84)	NC score	0.154873 (rank : 101)
Query Neighborhood Hits	191	Target Neighborhood Hits	148	Shared Neighborhood Hits	55
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH2_HUMAN
θ value	0.00390308 (rank : 85)	NC score	0.144147 (rank : 107)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	55
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.00390308 (rank : 86)	NC score	0.143977 (rank : 108)
Query Neighborhood Hits	191	Target Neighborhood Hits	171	Shared Neighborhood Hits	54
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH3_HUMAN
θ value	0.00390308 (rank : 87)	NC score	0.144486 (rank : 106)
Query Neighborhood Hits	191	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

MYO10_HUMAN
θ value	0.00869519 (rank : 88)	NC score	0.054495 (rank : 255)
Query Neighborhood Hits	191	Target Neighborhood Hits	920	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PKHA6_MOUSE
θ value	0.0113563 (rank : 89)	NC score	0.181504 (rank : 91)
Query Neighborhood Hits	191	Target Neighborhood Hits	591	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RHG25_HUMAN
θ value	0.0113563 (rank : 90)	NC score	0.125255 (rank : 117)
Query Neighborhood Hits	191	Target Neighborhood Hits	550	Shared Neighborhood Hits	74
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	0.0113563 (rank : 91)	NC score	0.125147 (rank : 118)
Query Neighborhood Hits	191	Target Neighborhood Hits	492	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH1_HUMAN
θ value	0.0148317 (rank : 92)	NC score	0.141891 (rank : 109)
Query Neighborhood Hits	191	Target Neighborhood Hits	184	Shared Neighborhood Hits	60
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.0148317 (rank : 93)	NC score	0.139531 (rank : 111)
Query Neighborhood Hits	191	Target Neighborhood Hits	176	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

PKHA4_MOUSE
θ value	0.0148317 (rank : 94)	NC score	0.160624 (rank : 94)
Query Neighborhood Hits	191	Target Neighborhood Hits	202	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

OSB11_HUMAN
θ value	0.0252991 (rank : 95)	NC score	0.077655 (rank : 178)
Query Neighborhood Hits	191	Target Neighborhood Hits	60	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_MOUSE
θ value	0.0252991 (rank : 96)	NC score	0.080006 (rank : 169)
Query Neighborhood Hits	191	Target Neighborhood Hits	71	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

PKHA4_HUMAN
θ value	0.0252991 (rank : 97)	NC score	0.149422 (rank : 103)
Query Neighborhood Hits	191	Target Neighborhood Hits	283	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA6_HUMAN
θ value	0.0252991 (rank : 98)	NC score	0.177411 (rank : 92)
Query Neighborhood Hits	191	Target Neighborhood Hits	556	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK2_HUMAN
θ value	0.0330416 (rank : 99)	NC score	0.162120 (rank : 93)
Query Neighborhood Hits	191	Target Neighborhood Hits	101	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

HAPIP_HUMAN
θ value	0.0431538 (rank : 100)	NC score	0.292826 (rank : 87)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	78
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

PLEK2_MOUSE
θ value	0.0431538 (rank : 101)	NC score	0.155962 (rank : 99)
Query Neighborhood Hits	191	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	0.0961366 (rank : 102)	NC score	0.152689 (rank : 102)
Query Neighborhood Hits	191	Target Neighborhood Hits	110	Shared Neighborhood Hits	46
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	0.0961366 (rank : 103)	NC score	0.155775 (rank : 100)
Query Neighborhood Hits	191	Target Neighborhood Hits	109	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

CJ118_HUMAN
θ value	0.21417 (rank : 104)	NC score	0.026590 (rank : 305)
Query Neighborhood Hits	191	Target Neighborhood Hits	937	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

PKHA5_HUMAN
θ value	0.365318 (rank : 105)	NC score	0.135760 (rank : 113)
Query Neighborhood Hits	191	Target Neighborhood Hits	455	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

TBCD1_MOUSE
θ value	0.365318 (rank : 106)	NC score	0.027696 (rank : 302)
Query Neighborhood Hits	191	Target Neighborhood Hits	241	Shared Neighborhood Hits	18
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

CEND2_HUMAN
θ value	0.47712 (rank : 107)	NC score	0.060257 (rank : 228)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	43
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CP250_MOUSE
θ value	0.47712 (rank : 108)	NC score	0.034371 (rank : 291)
Query Neighborhood Hits	191	Target Neighborhood Hits	1583	Shared Neighborhood Hits	53
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CENA1_HUMAN
θ value	0.62314 (rank : 109)	NC score	0.054932 (rank : 253)
Query Neighborhood Hits	191	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CNKR1_HUMAN
θ value	0.62314 (rank : 110)	NC score	0.111605 (rank : 129)
Query Neighborhood Hits	191	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

AKAP9_HUMAN
θ value	0.813845 (rank : 111)	NC score	0.033188 (rank : 293)
Query Neighborhood Hits	191	Target Neighborhood Hits	1710	Shared Neighborhood Hits	56
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

GCC2_MOUSE
θ value	0.813845 (rank : 112)	NC score	0.029823 (rank : 299)
Query Neighborhood Hits	191	Target Neighborhood Hits	1619	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

KTN1_HUMAN
θ value	0.813845 (rank : 113)	NC score	0.033425 (rank : 292)
Query Neighborhood Hits	191	Target Neighborhood Hits	1197	Shared Neighborhood Hits	52
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

NOLC1_HUMAN
θ value	0.813845 (rank : 114)	NC score	0.020969 (rank : 318)
Query Neighborhood Hits	191	Target Neighborhood Hits	452	Shared Neighborhood Hits	11
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PDE1A_MOUSE
θ value	0.813845 (rank : 115)	NC score	0.019939 (rank : 319)
Query Neighborhood Hits	191	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PKHB1_HUMAN
θ value	0.813845 (rank : 116)	NC score	0.064055 (rank : 218)
Query Neighborhood Hits	191	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

ZC3H3_MOUSE
θ value	0.813845 (rank : 117)	NC score	0.019161 (rank : 323)
Query Neighborhood Hits	191	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

3BP2_MOUSE
θ value	1.06291 (rank : 118)	NC score	0.118238 (rank : 120)
Query Neighborhood Hits	191	Target Neighborhood Hits	142	Shared Neighborhood Hits	42
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

MYH14_HUMAN
θ value	1.06291 (rank : 119)	NC score	0.023338 (rank : 315)
Query Neighborhood Hits	191	Target Neighborhood Hits	995	Shared Neighborhood Hits	44
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PKHA3_MOUSE
θ value	1.06291 (rank : 120)	NC score	0.077795 (rank : 177)
Query Neighborhood Hits	191	Target Neighborhood Hits	67	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

REST_HUMAN
θ value	1.06291 (rank : 121)	NC score	0.030233 (rank : 298)
Query Neighborhood Hits	191	Target Neighborhood Hits	1605	Shared Neighborhood Hits	55
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SPTB2_HUMAN
θ value	1.06291 (rank : 122)	NC score	0.037511 (rank : 286)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	55
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

3BP2_HUMAN
θ value	1.38821 (rank : 123)	NC score	0.116515 (rank : 123)
Query Neighborhood Hits	191	Target Neighborhood Hits	296	Shared Neighborhood Hits	44
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

C43BP_MOUSE
θ value	1.38821 (rank : 124)	NC score	0.084927 (rank : 154)
Query Neighborhood Hits	191	Target Neighborhood Hits	91	Shared Neighborhood Hits	36
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

DBND2_HUMAN
θ value	1.38821 (rank : 125)	NC score	0.024509 (rank : 311)
Query Neighborhood Hits	191	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQY9, Q9BQZ0, Q9BVL1, Q9H1F6, Q9NWZ0, Q9NY07, Q9NZ31	Gene names	DBNDD2, C20orf35
Domain Architecture
Description	Dysbindin domain-containing protein 2 (HSMNP1).

PDE1A_HUMAN
θ value	1.38821 (rank : 126)	NC score	0.019249 (rank : 321)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

TBCD1_HUMAN
θ value	1.38821 (rank : 127)	NC score	0.026339 (rank : 306)
Query Neighborhood Hits	191	Target Neighborhood Hits	276	Shared Neighborhood Hits	22
SwissProt Accessions	Q86TI0, Q96K82, Q9UPP4	Gene names	TBC1D1, KIAA1108
Domain Architecture
Description	TBC1 domain family member 1.

AZI1_MOUSE
θ value	1.81305 (rank : 128)	NC score	0.044641 (rank : 283)
Query Neighborhood Hits	191	Target Neighborhood Hits	990	Shared Neighborhood Hits	47
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

DGKH_HUMAN
θ value	1.81305 (rank : 129)	NC score	0.069150 (rank : 202)
Query Neighborhood Hits	191	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

ODO1_MOUSE
θ value	1.81305 (rank : 130)	NC score	0.038545 (rank : 285)
Query Neighborhood Hits	191	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q60597, Q80Y57, Q8K2Z3	Gene names	Ogdh
Domain Architecture
Description	2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).

PDE1B_HUMAN
θ value	1.81305 (rank : 131)	NC score	0.023884 (rank : 314)
Query Neighborhood Hits	191	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1B_MOUSE
θ value	1.81305 (rank : 132)	NC score	0.022554 (rank : 316)
Query Neighborhood Hits	191	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

TRPM3_HUMAN
θ value	1.81305 (rank : 133)	NC score	0.013802 (rank : 335)
Query Neighborhood Hits	191	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

ZN318_MOUSE
θ value	1.81305 (rank : 134)	NC score	0.029700 (rank : 301)
Query Neighborhood Hits	191	Target Neighborhood Hits	642	Shared Neighborhood Hits	31
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

AFF4_MOUSE
θ value	2.36792 (rank : 135)	NC score	0.010868 (rank : 337)
Query Neighborhood Hits	191	Target Neighborhood Hits	581	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

AN32B_MOUSE
θ value	2.36792 (rank : 136)	NC score	0.007744 (rank : 341)
Query Neighborhood Hits	191	Target Neighborhood Hits	236	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

CCD96_MOUSE
θ value	2.36792 (rank : 137)	NC score	0.045890 (rank : 282)
Query Neighborhood Hits	191	Target Neighborhood Hits	704	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CENA2_HUMAN
θ value	2.36792 (rank : 138)	NC score	0.043776 (rank : 284)
Query Neighborhood Hits	191	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CROCC_HUMAN
θ value	2.36792 (rank : 139)	NC score	0.030670 (rank : 297)
Query Neighborhood Hits	191	Target Neighborhood Hits	1409	Shared Neighborhood Hits	51
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

DGLA_HUMAN
θ value	2.36792 (rank : 140)	NC score	0.018272 (rank : 325)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4D2, Q6WQJ0	Gene names	NSDDR, C11orf11, KIAA0659
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase alpha (EC 3.1.1.-) (DGL-alpha) (Neural stem cell-derived dendrite regulator).

FGD5_HUMAN
θ value	2.36792 (rank : 141)	NC score	0.320724 (rank : 80)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	63
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	2.36792 (rank : 142)	NC score	0.307351 (rank : 83)
Query Neighborhood Hits	191	Target Neighborhood Hits	170	Shared Neighborhood Hits	62
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

MYH6_MOUSE
θ value	2.36792 (rank : 143)	NC score	0.026678 (rank : 304)
Query Neighborhood Hits	191	Target Neighborhood Hits	1501	Shared Neighborhood Hits	55
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

ODO1_HUMAN
θ value	2.36792 (rank : 144)	NC score	0.037023 (rank : 287)
Query Neighborhood Hits	191	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q02218	Gene names	OGDH
Domain Architecture
Description	2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).

SYCP2_HUMAN
θ value	2.36792 (rank : 145)	NC score	0.017811 (rank : 326)
Query Neighborhood Hits	191	Target Neighborhood Hits	230	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX26, O75763, Q5JX11, Q9NTX8, Q9UG27	Gene names	SYCP2, SCP2
Domain Architecture	No domain graphic available
Description	Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (hsSCP2).

BAZ1B_HUMAN
θ value	3.0926 (rank : 146)	NC score	0.017176 (rank : 327)
Query Neighborhood Hits	191	Target Neighborhood Hits	701	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

C43BP_HUMAN
θ value	3.0926 (rank : 147)	NC score	0.080092 (rank : 168)
Query Neighborhood Hits	191	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CJ118_MOUSE
θ value	3.0926 (rank : 148)	NC score	0.035164 (rank : 289)
Query Neighborhood Hits	191	Target Neighborhood Hits	1132	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

MORC3_HUMAN
θ value	3.0926 (rank : 149)	NC score	0.024957 (rank : 310)
Query Neighborhood Hits	191	Target Neighborhood Hits	489	Shared Neighborhood Hits	34
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

MYH6_HUMAN
θ value	3.0926 (rank : 150)	NC score	0.025078 (rank : 309)
Query Neighborhood Hits	191	Target Neighborhood Hits	1426	Shared Neighborhood Hits	52
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
θ value	3.0926 (rank : 151)	NC score	0.025838 (rank : 308)
Query Neighborhood Hits	191	Target Neighborhood Hits	1559	Shared Neighborhood Hits	56
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

PKHB1_MOUSE
θ value	3.0926 (rank : 152)	NC score	0.050581 (rank : 275)
Query Neighborhood Hits	191	Target Neighborhood Hits	47	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

ANK2_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.014713 (rank : 334)
Query Neighborhood Hits	191	Target Neighborhood Hits	1615	Shared Neighborhood Hits	44
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

AZI1_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.047101 (rank : 281)
Query Neighborhood Hits	191	Target Neighborhood Hits	1000	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CS016_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.018768 (rank : 324)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	10
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DGLA_MOUSE
θ value	4.03905 (rank : 156)	NC score	0.016761 (rank : 329)
Query Neighborhood Hits	191	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q6WQJ1, Q6ZQ76	Gene names	Nsddr, Kiaa0659
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase alpha (EC 3.1.1.-) (DGL-alpha) (Neural stem cell-derived dendrite regulator).

MYO5C_HUMAN
θ value	4.03905 (rank : 157)	NC score	0.024047 (rank : 312)
Query Neighborhood Hits	191	Target Neighborhood Hits	1206	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

NAF1_MOUSE
θ value	4.03905 (rank : 158)	NC score	0.030866 (rank : 295)
Query Neighborhood Hits	191	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

OSBP1_HUMAN
θ value	4.03905 (rank : 159)	NC score	0.049041 (rank : 280)
Query Neighborhood Hits	191	Target Neighborhood Hits	180	Shared Neighborhood Hits	43
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PCNT_HUMAN
θ value	4.03905 (rank : 160)	NC score	0.034513 (rank : 290)
Query Neighborhood Hits	191	Target Neighborhood Hits	1551	Shared Neighborhood Hits	55
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

TPR_HUMAN
θ value	4.03905 (rank : 161)	NC score	0.031403 (rank : 294)
Query Neighborhood Hits	191	Target Neighborhood Hits	1921	Shared Neighborhood Hits	67
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

BCL9_MOUSE
θ value	5.27518 (rank : 162)	NC score	0.012787 (rank : 336)
Query Neighborhood Hits	191	Target Neighborhood Hits	770	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

OSBL9_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.084763 (rank : 155)
Query Neighborhood Hits	191	Target Neighborhood Hits	138	Shared Neighborhood Hits	46
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

STAP1_MOUSE
θ value	5.27518 (rank : 164)	NC score	0.029788 (rank : 300)
Query Neighborhood Hits	191	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JM90, Q3TRM1, Q6PES6	Gene names	Stap1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1).

THAP4_MOUSE
θ value	5.27518 (rank : 165)	NC score	0.015087 (rank : 332)
Query Neighborhood Hits	191	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

BLNK_MOUSE
θ value	6.88961 (rank : 166)	NC score	0.036617 (rank : 288)
Query Neighborhood Hits	191	Target Neighborhood Hits	296	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CDCA7_MOUSE
θ value	6.88961 (rank : 167)	NC score	0.008427 (rank : 340)
Query Neighborhood Hits	191	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D0M2, Q3TIS1, Q3U511, Q6NZE5, Q8C1A0	Gene names	Cdca7
Domain Architecture	No domain graphic available
Description	Cell division cycle-associated protein 7.

CHD8_HUMAN
θ value	6.88961 (rank : 168)	NC score	0.001402 (rank : 345)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCK8, Q68DQ0, Q8N3Z9, Q8NCY4, Q8TBR9, Q96F26	Gene names	CHD8, HELSNF1, KIAA1564
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 8 (EC 3.6.1.-) (ATP- dependent helicase CHD8) (CHD-8) (Helicase with SNF2 domain 1).

CROCC_MOUSE
θ value	6.88961 (rank : 169)	NC score	0.027528 (rank : 303)
Query Neighborhood Hits	191	Target Neighborhood Hits	1460	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CSPG2_MOUSE
θ value	6.88961 (rank : 170)	NC score	-0.001366 (rank : 346)
Query Neighborhood Hits	191	Target Neighborhood Hits	711	Shared Neighborhood Hits	8
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

FA53C_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.009473 (rank : 339)
Query Neighborhood Hits	191	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BXQ8, Q3U4J2	Gene names	Fam53c
Domain Architecture	No domain graphic available
Description	Protein FAM53C.

HOOK3_MOUSE
θ value	6.88961 (rank : 172)	NC score	0.030794 (rank : 296)
Query Neighborhood Hits	191	Target Neighborhood Hits	1007	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

OLR1_MOUSE
θ value	6.88961 (rank : 173)	NC score	0.019431 (rank : 320)
Query Neighborhood Hits	191	Target Neighborhood Hits	596	Shared Neighborhood Hits	31
SwissProt Accessions	Q9EQ09	Gene names	Olr1, Lox1
Domain Architecture	No domain graphic available
Description	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-type oxidized LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (Lectin-like oxLDL receptor 1) (LOX-1) [Contains: Oxidized low-density lipoprotein receptor 1, soluble form].

SCN8A_HUMAN
θ value	6.88961 (rank : 174)	NC score	0.003094 (rank : 344)
Query Neighborhood Hits	191	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SRRM1_HUMAN
θ value	6.88961 (rank : 175)	NC score	0.019240 (rank : 322)
Query Neighborhood Hits	191	Target Neighborhood Hits	690	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

ZBT11_HUMAN
θ value	6.88961 (rank : 176)	NC score	-0.007393 (rank : 349)
Query Neighborhood Hits	191	Target Neighborhood Hits	873	Shared Neighborhood Hits	5
SwissProt Accessions	O95625	Gene names	ZBTB11
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 11.

BPA1_MOUSE
θ value	8.99809 (rank : 177)	NC score	0.022428 (rank : 317)
Query Neighborhood Hits	191	Target Neighborhood Hits	1477	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BPAEA_HUMAN
θ value	8.99809 (rank : 178)	NC score	0.023891 (rank : 313)
Query Neighborhood Hits	191	Target Neighborhood Hits	1369	Shared Neighborhood Hits	45
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CENA2_MOUSE
θ value	8.99809 (rank : 179)	NC score	0.026190 (rank : 307)
Query Neighborhood Hits	191	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CENPQ_MOUSE
θ value	8.99809 (rank : 180)	NC score	0.016779 (rank : 328)
Query Neighborhood Hits	191	Target Neighborhood Hits	160	Shared Neighborhood Hits	16
SwissProt Accessions	Q9CPQ5, Q8C2G4, Q8VEF8, Q9CX70	Gene names	Cenpq
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

DMRT1_HUMAN
θ value	8.99809 (rank : 181)	NC score	0.007106 (rank : 343)
Query Neighborhood Hits	191	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5R6, Q8IW77	Gene names	DMRT1, DMT1
Domain Architecture
Description	Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1).

GMEB2_MOUSE
θ value	8.99809 (rank : 182)	NC score	0.007304 (rank : 342)
Query Neighborhood Hits	191	Target Neighborhood Hits	64	Shared Neighborhood Hits	7
SwissProt Accessions	P58929, Q6PCY0	Gene names	Gmeb2
Domain Architecture	No domain graphic available
Description	Glucocorticoid modulatory element-binding protein 2 (GMEB-2).

LRSM1_MOUSE
θ value	8.99809 (rank : 183)	NC score	0.015037 (rank : 333)
Query Neighborhood Hits	191	Target Neighborhood Hits	874	Shared Neighborhood Hits	33
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MAZ_MOUSE
θ value	8.99809 (rank : 184)	NC score	-0.007577 (rank : 350)
Query Neighborhood Hits	191	Target Neighborhood Hits	745	Shared Neighborhood Hits	3
SwissProt Accessions	P56671, Q9R1W0	Gene names	Maz
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1).

NUAK1_MOUSE
θ value	8.99809 (rank : 185)	NC score	-0.007080 (rank : 348)
Query Neighborhood Hits	191	Target Neighborhood Hits	881	Shared Neighborhood Hits	5
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

PDE1C_HUMAN
θ value	8.99809 (rank : 186)	NC score	0.016302 (rank : 330)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.016217 (rank : 331)
Query Neighborhood Hits	191	Target Neighborhood Hits	161	Shared Neighborhood Hits	9
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PKHA1_HUMAN
θ value	8.99809 (rank : 188)	NC score	0.094142 (rank : 139)
Query Neighborhood Hits	191	Target Neighborhood Hits	127	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	8.99809 (rank : 189)	NC score	0.092486 (rank : 141)
Query Neighborhood Hits	191	Target Neighborhood Hits	120	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

SNX8_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.010073 (rank : 338)
Query Neighborhood Hits	191	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5X2, Q96I67	Gene names	SNX8
Domain Architecture
Description	Sorting nexin-8.

TLR5_MOUSE
θ value	8.99809 (rank : 191)	NC score	-0.001696 (rank : 347)
Query Neighborhood Hits	191	Target Neighborhood Hits	287	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

ABI1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.076367 (rank : 182)
Query Neighborhood Hits	191	Target Neighborhood Hits	257	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.080601 (rank : 167)
Query Neighborhood Hits	191	Target Neighborhood Hits	246	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.082963 (rank : 159)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.083761 (rank : 156)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.073296 (rank : 189)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.070668 (rank : 195)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.064337 (rank : 217)
Query Neighborhood Hits	191	Target Neighborhood Hits	537	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.062635 (rank : 222)
Query Neighborhood Hits	191	Target Neighborhood Hits	496	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALS2_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.052682 (rank : 268)
Query Neighborhood Hits	191	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ANM2_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.054186 (rank : 259)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.050910 (rank : 273)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.326211 (rank : 77)
Query Neighborhood Hits	191	Target Neighborhood Hits	176	Shared Neighborhood Hits	53
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.306371 (rank : 84)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	51
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.289733 (rank : 89)
Query Neighborhood Hits	191	Target Neighborhood Hits	142	Shared Neighborhood Hits	54
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.310960 (rank : 82)
Query Neighborhood Hits	191	Target Neighborhood Hits	120	Shared Neighborhood Hits	54
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGC_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.302413 (rank : 86)
Query Neighborhood Hits	191	Target Neighborhood Hits	351	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.305246 (rank : 85)
Query Neighborhood Hits	191	Target Neighborhood Hits	344	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BCAR1_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.053020 (rank : 266)
Query Neighborhood Hits	191	Target Neighborhood Hits	438	Shared Neighborhood Hits	24
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.076440 (rank : 181)
Query Neighborhood Hits	191	Target Neighborhood Hits	156	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.062865 (rank : 221)
Query Neighborhood Hits	191	Target Neighborhood Hits	197	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIG1_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.052305 (rank : 270)
Query Neighborhood Hits	191	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.053405 (rank : 264)
Query Neighborhood Hits	191	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

CASL_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.050507 (rank : 276)
Query Neighborhood Hits	191	Target Neighborhood Hits	259	Shared Neighborhood Hits	21
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CD2AP_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.115960 (rank : 125)
Query Neighborhood Hits	191	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.115898 (rank : 126)
Query Neighborhood Hits	191	Target Neighborhood Hits	336	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CHIN_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.059243 (rank : 235)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	16
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.059440 (rank : 233)
Query Neighborhood Hits	191	Target Neighborhood Hits	229	Shared Neighborhood Hits	16
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.055841 (rank : 247)
Query Neighborhood Hits	191	Target Neighborhood Hits	220	Shared Neighborhood Hits	16
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.056371 (rank : 244)
Query Neighborhood Hits	191	Target Neighborhood Hits	130	Shared Neighborhood Hits	14
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CNKR2_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.073002 (rank : 193)
Query Neighborhood Hits	191	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.073095 (rank : 192)
Query Neighborhood Hits	191	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRKL_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.078986 (rank : 174)
Query Neighborhood Hits	191	Target Neighborhood Hits	313	Shared Neighborhood Hits	22
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.077492 (rank : 179)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.073206 (rank : 191)
Query Neighborhood Hits	191	Target Neighborhood Hits	308	Shared Neighborhood Hits	23
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.075109 (rank : 186)
Query Neighborhood Hits	191	Target Neighborhood Hits	314	Shared Neighborhood Hits	24
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.052396 (rank : 269)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CT152_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.069171 (rank : 201)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

CT152_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.055306 (rank : 251)
Query Neighborhood Hits	191	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

DBNL_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.064928 (rank : 214)
Query Neighborhood Hits	191	Target Neighborhood Hits	244	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.061905 (rank : 223)
Query Neighborhood Hits	191	Target Neighborhood Hits	306	Shared Neighborhood Hits	23
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EEA1_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.054327 (rank : 257)
Query Neighborhood Hits	191	Target Neighborhood Hits	1796	Shared Neighborhood Hits	67
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.054636 (rank : 254)
Query Neighborhood Hits	191	Target Neighborhood Hits	1637	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EP15_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.050134 (rank : 279)
Query Neighborhood Hits	191	Target Neighborhood Hits	1021	Shared Neighborhood Hits	48
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FNBP2_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.065361 (rank : 211)
Query Neighborhood Hits	191	Target Neighborhood Hits	432	Shared Neighborhood Hits	37
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYV1_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.068393 (rank : 204)
Query Neighborhood Hits	191	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.067365 (rank : 206)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GBF1_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.054064 (rank : 260)
Query Neighborhood Hits	191	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

GRAP2_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.080789 (rank : 166)
Query Neighborhood Hits	191	Target Neighborhood Hits	304	Shared Neighborhood Hits	22
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.081043 (rank : 164)
Query Neighborhood Hits	191	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.100276 (rank : 136)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	25
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.099521 (rank : 138)
Query Neighborhood Hits	191	Target Neighborhood Hits	309	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.089277 (rank : 147)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	23
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.089229 (rank : 148)
Query Neighborhood Hits	191	Target Neighborhood Hits	312	Shared Neighborhood Hits	23
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.082640 (rank : 160)
Query Neighborhood Hits	191	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.081440 (rank : 162)
Query Neighborhood Hits	191	Target Neighborhood Hits	329	Shared Neighborhood Hits	26
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.070120 (rank : 198)
Query Neighborhood Hits	191	Target Neighborhood Hits	517	Shared Neighborhood Hits	25
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.070351 (rank : 196)
Query Neighborhood Hits	191	Target Neighborhood Hits	589	Shared Neighborhood Hits	26
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IQEC3_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.060216 (rank : 229)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.055804 (rank : 248)
Query Neighborhood Hits	191	Target Neighborhood Hits	274	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

LASP1_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.060723 (rank : 227)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.059112 (rank : 237)
Query Neighborhood Hits	191	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LBC_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.292804 (rank : 88)
Query Neighborhood Hits	191	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LMO7_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.053667 (rank : 262)
Query Neighborhood Hits	191	Target Neighborhood Hits	507	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MCF2L_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.313141 (rank : 81)
Query Neighborhood Hits	191	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.342656 (rank : 71)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NCF1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.117449 (rank : 121)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.111691 (rank : 128)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.107642 (rank : 132)
Query Neighborhood Hits	191	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.090502 (rank : 146)
Query Neighborhood Hits	191	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.090618 (rank : 145)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.107697 (rank : 131)
Query Neighborhood Hits	191	Target Neighborhood Hits	312	Shared Neighborhood Hits	28
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.103800 (rank : 134)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.059257 (rank : 234)
Query Neighborhood Hits	191	Target Neighborhood Hits	457	Shared Neighborhood Hits	36
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.057738 (rank : 239)
Query Neighborhood Hits	191	Target Neighborhood Hits	100	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.066763 (rank : 209)
Query Neighborhood Hits	191	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.059174 (rank : 236)
Query Neighborhood Hits	191	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.064357 (rank : 216)
Query Neighborhood Hits	191	Target Neighborhood Hits	466	Shared Neighborhood Hits	22
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.063589 (rank : 220)
Query Neighborhood Hits	191	Target Neighborhood Hits	467	Shared Neighborhood Hits	22
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.061808 (rank : 224)
Query Neighborhood Hits	191	Target Neighborhood Hits	479	Shared Neighborhood Hits	32
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.058307 (rank : 238)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	32
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.054977 (rank : 252)
Query Neighborhood Hits	191	Target Neighborhood Hits	543	Shared Neighborhood Hits	34
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.054336 (rank : 256)
Query Neighborhood Hits	191	Target Neighborhood Hits	519	Shared Neighborhood Hits	39
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.050301 (rank : 277)
Query Neighborhood Hits	191	Target Neighborhood Hits	320	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.055516 (rank : 249)
Query Neighborhood Hits	191	Target Neighborhood Hits	339	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.055976 (rank : 245)
Query Neighborhood Hits	191	Target Neighborhood Hits	382	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.055461 (rank : 250)
Query Neighborhood Hits	191	Target Neighborhood Hits	385	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.057729 (rank : 240)
Query Neighborhood Hits	191	Target Neighborhood Hits	380	Shared Neighborhood Hits	36
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.053685 (rank : 261)
Query Neighborhood Hits	191	Target Neighborhood Hits	128	Shared Neighborhood Hits	17
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.055922 (rank : 246)
Query Neighborhood Hits	191	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA2_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.091886 (rank : 143)
Query Neighborhood Hits	191	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.099995 (rank : 137)
Query Neighborhood Hits	191	Target Neighborhood Hits	116	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA3_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.061191 (rank : 225)
Query Neighborhood Hits	191	Target Neighborhood Hits	66	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHF1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.146712 (rank : 104)
Query Neighborhood Hits	191	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.145083 (rank : 105)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.157683 (rank : 97)
Query Neighborhood Hits	191	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.158162 (rank : 96)
Query Neighborhood Hits	191	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHG1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.445574 (rank : 53)
Query Neighborhood Hits	191	Target Neighborhood Hits	174	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.239057 (rank : 90)
Query Neighborhood Hits	191	Target Neighborhood Hits	200	Shared Neighborhood Hits	51
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.080952 (rank : 165)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.082632 (rank : 161)
Query Neighborhood Hits	191	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.066974 (rank : 208)
Query Neighborhood Hits	191	Target Neighborhood Hits	280	Shared Neighborhood Hits	21
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.078902 (rank : 175)
Query Neighborhood Hits	191	Target Neighborhood Hits	389	Shared Neighborhood Hits	37
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.073557 (rank : 188)
Query Neighborhood Hits	191	Target Neighborhood Hits	377	Shared Neighborhood Hits	32
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PSD3_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.065341 (rank : 212)
Query Neighborhood Hits	191	Target Neighborhood Hits	75	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.057687 (rank : 241)
Query Neighborhood Hits	191	Target Neighborhood Hits	178	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD4_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.059819 (rank : 231)
Query Neighborhood Hits	191	Target Neighborhood Hits	78	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RBNS5_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.070981 (rank : 194)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.069222 (rank : 200)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.054231 (rank : 258)
Query Neighborhood Hits	191	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.053134 (rank : 265)
Query Neighborhood Hits	191	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.052912 (rank : 267)
Query Neighborhood Hits	191	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.078026 (rank : 176)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.064590 (rank : 215)
Query Neighborhood Hits	191	Target Neighborhood Hits	281	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB2_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.051103 (rank : 272)
Query Neighborhood Hits	191	Target Neighborhood Hits	263	Shared Neighborhood Hits	22
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.050806 (rank : 274)
Query Neighborhood Hits	191	Target Neighborhood Hits	246	Shared Neighborhood Hits	20
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.059681 (rank : 232)
Query Neighborhood Hits	191	Target Neighborhood Hits	848	Shared Neighborhood Hits	51
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.056706 (rank : 242)
Query Neighborhood Hits	191	Target Neighborhood Hits	765	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.060140 (rank : 230)
Query Neighborhood Hits	191	Target Neighborhood Hits	1208	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.063607 (rank : 219)
Query Neighborhood Hits	191	Target Neighborhood Hits	820	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.073890 (rank : 187)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.069838 (rank : 199)
Query Neighborhood Hits	191	Target Neighborhood Hits	291	Shared Neighborhood Hits	23
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.070142 (rank : 197)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	27
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.068692 (rank : 203)
Query Neighborhood Hits	191	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.073293 (rank : 190)
Query Neighborhood Hits	191	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.075383 (rank : 185)
Query Neighborhood Hits	191	Target Neighborhood Hits	236	Shared Neighborhood Hits	23
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.124116 (rank : 119)
Query Neighborhood Hits	191	Target Neighborhood Hits	341	Shared Neighborhood Hits	30
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.116368 (rank : 124)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.050157 (rank : 278)
Query Neighborhood Hits	191	Target Neighborhood Hits	1041	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.067524 (rank : 205)
Query Neighborhood Hits	191	Target Neighborhood Hits	446	Shared Neighborhood Hits	30
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SRBS1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.108715 (rank : 130)
Query Neighborhood Hits	191	Target Neighborhood Hits	396	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.113130 (rank : 127)
Query Neighborhood Hits	191	Target Neighborhood Hits	409	Shared Neighborhood Hits	28
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.079155 (rank : 173)
Query Neighborhood Hits	191	Target Neighborhood Hits	269	Shared Neighborhood Hits	25
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.077248 (rank : 180)
Query Neighborhood Hits	191	Target Neighborhood Hits	292	Shared Neighborhood Hits	23
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.067006 (rank : 207)
Query Neighborhood Hits	191	Target Neighborhood Hits	390	Shared Neighborhood Hits	33
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.065045 (rank : 213)
Query Neighborhood Hits	191	Target Neighborhood Hits	331	Shared Neighborhood Hits	31
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.065447 (rank : 210)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	31
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.085068 (rank : 152)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	23
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.085872 (rank : 151)
Query Neighborhood Hits	191	Target Neighborhood Hits	232	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.091677 (rank : 144)
Query Neighborhood Hits	191	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.088633 (rank : 149)
Query Neighborhood Hits	191	Target Neighborhood Hits	268	Shared Neighborhood Hits	24
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.079758 (rank : 170)
Query Neighborhood Hits	191	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.079290 (rank : 172)
Query Neighborhood Hits	191	Target Neighborhood Hits	273	Shared Neighborhood Hits	21
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.075779 (rank : 184)
Query Neighborhood Hits	191	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.076090 (rank : 183)
Query Neighborhood Hits	191	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.079724 (rank : 171)
Query Neighborhood Hits	191	Target Neighborhood Hits	872	Shared Neighborhood Hits	44
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.081315 (rank : 163)
Query Neighborhood Hits	191	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TRIO_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.117227 (rank : 122)
Query Neighborhood Hits	191	Target Neighborhood Hits	1580	Shared Neighborhood Hits	91
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

VINEX_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.104462 (rank : 133)
Query Neighborhood Hits	191	Target Neighborhood Hits	270	Shared Neighborhood Hits	25
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.103776 (rank : 135)
Query Neighborhood Hits	191	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZFY16_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.083740 (rank : 157)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.086582 (rank : 150)
Query Neighborhood Hits	191	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.061142 (rank : 226)
Query Neighborhood Hits	191	Target Neighborhood Hits	206	Shared Neighborhood Hits	19
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.056656 (rank : 243)
Query Neighborhood Hits	191	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.082980 (rank : 158)
Query Neighborhood Hits	191	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.084960 (rank : 153)
Query Neighborhood Hits	191	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.093743 (rank : 140)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.053414 (rank : 263)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.052236 (rank : 271)
Query Neighborhood Hits	191	Target Neighborhood Hits	153	Shared Neighborhood Hits	16
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.092161 (rank : 142)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	14
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

GNRP_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	191
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
NC score	0.978944 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	191	Target Neighborhood Hits	239	Shared Neighborhood Hits	143
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS2_HUMAN
NC score	0.679141 (rank : 3)	θ value	1.46948e-34 (rank : 5)
Query Neighborhood Hits	191	Target Neighborhood Hits	193	Shared Neighborhood Hits	57
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.672810 (rank : 4)	θ value	3.4976e-36 (rank : 4)
Query Neighborhood Hits	191	Target Neighborhood Hits	274	Shared Neighborhood Hits	61
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.664183 (rank : 5)	θ value	4.13158e-37 (rank : 3)
Query Neighborhood Hits	191	Target Neighborhood Hits	281	Shared Neighborhood Hits	58
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

RPGF1_HUMAN
NC score	0.638569 (rank : 6)	θ value	1.28732e-30 (rank : 6)
Query Neighborhood Hits	191	Target Neighborhood Hits	262	Shared Neighborhood Hits	26
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RGL1_HUMAN
NC score	0.605110 (rank : 7)	θ value	1.12775e-26 (rank : 7)
Query Neighborhood Hits	191	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
NC score	0.593716 (rank : 8)	θ value	3.28125e-26 (rank : 8)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

PREX1_HUMAN
NC score	0.573249 (rank : 9)	θ value	3.64472e-09 (rank : 52)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_MOUSE
NC score	0.564604 (rank : 10)	θ value	3.18553e-13 (rank : 34)
Query Neighborhood Hits	191	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

GNDS_MOUSE
NC score	0.561990 (rank : 11)	θ value	5.79196e-23 (rank : 10)
Query Neighborhood Hits	191	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_MOUSE
NC score	0.561646 (rank : 12)	θ value	1.13037e-18 (rank : 16)
Query Neighborhood Hits	191	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_HUMAN
NC score	0.561442 (rank : 13)	θ value	7.32683e-18 (rank : 18)
Query Neighborhood Hits	191	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

ECT2_HUMAN
NC score	0.559022 (rank : 14)	θ value	1.58096e-12 (rank : 38)
Query Neighborhood Hits	191	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RPGF5_HUMAN
NC score	0.555252 (rank : 15)	θ value	1.2077e-20 (rank : 13)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	23
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RGDSR_HUMAN
NC score	0.552781 (rank : 16)	θ value	3.51386e-20 (rank : 14)
Query Neighborhood Hits	191	Target Neighborhood Hits	63	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

GNDS_HUMAN
NC score	0.551587 (rank : 17)	θ value	9.87957e-23 (rank : 11)
Query Neighborhood Hits	191	Target Neighborhood Hits	201	Shared Neighborhood Hits	23
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RPGF5_MOUSE
NC score	0.547499 (rank : 18)	θ value	6.40375e-22 (rank : 12)
Query Neighborhood Hits	191	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

FGD3_MOUSE
NC score	0.527205 (rank : 19)	θ value	2.98157e-11 (rank : 45)
Query Neighborhood Hits	191	Target Neighborhood Hits	257	Shared Neighborhood Hits	76
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

NGEF_HUMAN
NC score	0.524865 (rank : 20)	θ value	1.2105e-12 (rank : 37)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD4_HUMAN
NC score	0.522744 (rank : 21)	θ value	8.38298e-14 (rank : 28)
Query Neighborhood Hits	191	Target Neighborhood Hits	219	Shared Neighborhood Hits	80
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.519215 (rank : 22)	θ value	6.00763e-12 (rank : 41)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD2_HUMAN
NC score	0.518647 (rank : 23)	θ value	1.09485e-13 (rank : 29)
Query Neighborhood Hits	191	Target Neighborhood Hits	151	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

GRP3_HUMAN
NC score	0.518200 (rank : 24)	θ value	5.59698e-26 (rank : 9)
Query Neighborhood Hits	191	Target Neighborhood Hits	131	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

FGD3_HUMAN
NC score	0.511716 (rank : 25)	θ value	2.98157e-11 (rank : 44)
Query Neighborhood Hits	191	Target Neighborhood Hits	249	Shared Neighborhood Hits	61
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

NGEF_MOUSE
NC score	0.510848 (rank : 26)	θ value	1.86753e-13 (rank : 33)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RPGF4_HUMAN
NC score	0.508192 (rank : 27)	θ value	2.97466e-19 (rank : 15)
Query Neighborhood Hits	191	Target Neighborhood Hits	88	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

FGD2_MOUSE
NC score	0.506929 (rank : 28)	θ value	1.52774e-15 (rank : 23)
Query Neighborhood Hits	191	Target Neighborhood Hits	163	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

RPGF4_MOUSE
NC score	0.505199 (rank : 29)	θ value	1.47631e-18 (rank : 17)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

ARHG5_HUMAN
NC score	0.501098 (rank : 30)	θ value	2.52405e-10 (rank : 49)
Query Neighborhood Hits	191	Target Neighborhood Hits	172	Shared Neighborhood Hits	59
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG4_MOUSE
NC score	0.496420 (rank : 31)	θ value	1.38499e-08 (rank : 56)
Query Neighborhood Hits	191	Target Neighborhood Hits	185	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.496149 (rank : 32)	θ value	2.36244e-08 (rank : 57)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RPGF2_HUMAN
NC score	0.494331 (rank : 33)	θ value	1.63225e-17 (rank : 20)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

FGD1_HUMAN
NC score	0.494212 (rank : 34)	θ value	1.133e-10 (rank : 48)
Query Neighborhood Hits	191	Target Neighborhood Hits	367	Shared Neighborhood Hits	75
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.493527 (rank : 35)	θ value	6.64225e-11 (rank : 47)
Query Neighborhood Hits	191	Target Neighborhood Hits	387	Shared Neighborhood Hits	75
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGA_HUMAN
NC score	0.493519 (rank : 36)	θ value	1.2105e-12 (rank : 36)
Query Neighborhood Hits	191	Target Neighborhood Hits	187	Shared Neighborhood Hits	63
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.491888 (rank : 37)	θ value	2.28291e-11 (rank : 43)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	58
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_MOUSE
NC score	0.483338 (rank : 38)	θ value	3.08544e-08 (rank : 59)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	58
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

RPGF3_HUMAN
NC score	0.475604 (rank : 39)	θ value	2.20605e-14 (rank : 26)
Query Neighborhood Hits	191	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

ARHGG_HUMAN
NC score	0.475221 (rank : 40)	θ value	9.92553e-07 (rank : 64)
Query Neighborhood Hits	191	Target Neighborhood Hits	129	Shared Neighborhood Hits	58
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

RPGF6_HUMAN
NC score	0.474947 (rank : 41)	θ value	7.32683e-18 (rank : 19)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

ARHG9_HUMAN
NC score	0.474302 (rank : 42)	θ value	6.43352e-06 (rank : 73)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	62
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.473942 (rank : 43)	θ value	4.92598e-06 (rank : 72)
Query Neighborhood Hits	191	Target Neighborhood Hits	234	Shared Neighborhood Hits	62
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG3_HUMAN
NC score	0.470865 (rank : 44)	θ value	1.06045e-08 (rank : 54)
Query Neighborhood Hits	191	Target Neighborhood Hits	82	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.470414 (rank : 45)	θ value	1.06045e-08 (rank : 55)
Query Neighborhood Hits	191	Target Neighborhood Hits	85	Shared Neighborhood Hits	55
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

TIAM1_MOUSE
NC score	0.465845 (rank : 46)	θ value	4.0297e-08 (rank : 60)
Query Neighborhood Hits	191	Target Neighborhood Hits	205	Shared Neighborhood Hits	73
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.463788 (rank : 47)	θ value	2.36244e-08 (rank : 58)
Query Neighborhood Hits	191	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD6_MOUSE
NC score	0.463039 (rank : 48)	θ value	1.42992e-13 (rank : 31)
Query Neighborhood Hits	191	Target Neighborhood Hits	282	Shared Neighborhood Hits	81
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ARHG8_HUMAN
NC score	0.459781 (rank : 49)	θ value	1.29631e-06 (rank : 66)
Query Neighborhood Hits	191	Target Neighborhood Hits	85	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

RPGF3_MOUSE
NC score	0.458023 (rank : 50)	θ value	1.68911e-14 (rank : 25)
Query Neighborhood Hits	191	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

FGD6_HUMAN
NC score	0.455597 (rank : 51)	θ value	3.52202e-12 (rank : 39)
Query Neighborhood Hits	191	Target Neighborhood Hits	237	Shared Neighborhood Hits	86
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ARHGF_HUMAN
NC score	0.454967 (rank : 52)	θ value	2.79066e-09 (rank : 51)
Query Neighborhood Hits	191	Target Neighborhood Hits	214	Shared Neighborhood Hits	55
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PKHG1_HUMAN
NC score	0.445574 (rank : 53)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	191	Target Neighborhood Hits	174	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG8_MOUSE
NC score	0.431293 (rank : 54)	θ value	2.21117e-06 (rank : 69)
Query Neighborhood Hits	191	Target Neighborhood Hits	79	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

VAV2_HUMAN
NC score	0.395075 (rank : 55)	θ value	7.58209e-15 (rank : 24)
Query Neighborhood Hits	191	Target Neighborhood Hits	453	Shared Neighborhood Hits	65
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.393291 (rank : 56)	θ value	4.59992e-12 (rank : 40)
Query Neighborhood Hits	191	Target Neighborhood Hits	456	Shared Neighborhood Hits	66
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FARP2_MOUSE
NC score	0.386464 (rank : 57)	θ value	5.08577e-11 (rank : 46)
Query Neighborhood Hits	191	Target Neighborhood Hits	209	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG7_HUMAN
NC score	0.384919 (rank : 58)	θ value	1.69304e-06 (rank : 67)
Query Neighborhood Hits	191	Target Neighborhood Hits	347	Shared Neighborhood Hits	68
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DNMBP_MOUSE
NC score	0.381675 (rank : 59)	θ value	6.21693e-09 (rank : 53)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	62
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG7_MOUSE
NC score	0.380735 (rank : 60)	θ value	2.88788e-06 (rank : 70)
Query Neighborhood Hits	191	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV3_MOUSE
NC score	0.380613 (rank : 61)	θ value	2.61198e-07 (rank : 63)
Query Neighborhood Hits	191	Target Neighborhood Hits	404	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHGB_HUMAN
NC score	0.380003 (rank : 62)	θ value	1.69304e-06 (rank : 68)
Query Neighborhood Hits	191	Target Neighborhood Hits	375	Shared Neighborhood Hits	65
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

VAV3_HUMAN
NC score	0.373526 (rank : 63)	θ value	2.88788e-06 (rank : 71)
Query Neighborhood Hits	191	Target Neighborhood Hits	398	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

BCR_HUMAN
NC score	0.372991 (rank : 64)	θ value	8.10077e-17 (rank : 22)
Query Neighborhood Hits	191	Target Neighborhood Hits	204	Shared Neighborhood Hits	58
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.370394 (rank : 65)	θ value	4.74913e-17 (rank : 21)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

VAV_MOUSE
NC score	0.362042 (rank : 66)	θ value	9.92553e-07 (rank : 65)
Query Neighborhood Hits	191	Target Neighborhood Hits	430	Shared Neighborhood Hits	63
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.355938 (rank : 67)	θ value	6.87365e-08 (rank : 61)
Query Neighborhood Hits	191	Target Neighborhood Hits	452	Shared Neighborhood Hits	64
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

DNMBP_HUMAN
NC score	0.350517 (rank : 68)	θ value	0.000121331 (rank : 76)
Query Neighborhood Hits	191	Target Neighborhood Hits	413	Shared Neighborhood Hits	65
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FARP2_HUMAN
NC score	0.349727 (rank : 69)	θ value	1.02475e-11 (rank : 42)
Query Neighborhood Hits	191	Target Neighborhood Hits	240	Shared Neighborhood Hits	84
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ITSN2_HUMAN
NC score	0.348196 (rank : 70)	θ value	6.41864e-14 (rank : 27)
Query Neighborhood Hits	191	Target Neighborhood Hits	1173	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MCF2_HUMAN
NC score	0.342656 (rank : 71)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG6_HUMAN
NC score	0.339562 (rank : 72)	θ value	0.000602161 (rank : 79)
Query Neighborhood Hits	191	Target Neighborhood Hits	376	Shared Neighborhood Hits	62
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ITSN1_MOUSE
NC score	0.334868 (rank : 73)	θ value	1.86753e-13 (rank : 32)
Query Neighborhood Hits	191	Target Neighborhood Hits	1669	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.332900 (rank : 74)	θ value	1.09485e-13 (rank : 30)
Query Neighborhood Hits	191	Target Neighborhood Hits	1757	Shared Neighborhood Hits	100
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
NC score	0.331152 (rank : 75)	θ value	7.09661e-13 (rank : 35)
Query Neighborhood Hits	191	Target Neighborhood Hits	1371	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

RGNEF_MOUSE
NC score	0.329890 (rank : 76)	θ value	5.62301e-10 (rank : 50)
Query Neighborhood Hits	191	Target Neighborhood Hits	641	Shared Neighborhood Hits	72
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG1_HUMAN
NC score	0.326211 (rank : 77)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	191	Target Neighborhood Hits	176	Shared Neighborhood Hits	53
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

FARP1_HUMAN
NC score	0.323688 (rank : 78)	θ value	1.17247e-07 (rank : 62)
Query Neighborhood Hits	191	Target Neighborhood Hits	241	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG6_MOUSE
NC score	0.323648 (rank : 79)	θ value	0.00175202 (rank : 83)
Query Neighborhood Hits	191	Target Neighborhood Hits	394	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

FGD5_HUMAN
NC score	0.320724 (rank : 80)	θ value	2.36792 (rank : 141)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	63
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

MCF2L_MOUSE
NC score	0.313141 (rank : 81)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	191	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG2_MOUSE
NC score	0.310960 (rank : 82)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	191	Target Neighborhood Hits	120	Shared Neighborhood Hits	54
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

FGD5_MOUSE
NC score	0.307351 (rank : 83)	θ value	2.36792 (rank : 142)
Query Neighborhood Hits	191	Target Neighborhood Hits	170	Shared Neighborhood Hits	62
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG1_MOUSE
NC score	0.306371 (rank : 84)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	51
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGC_MOUSE
NC score	0.305246 (rank : 85)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	191	Target Neighborhood Hits	344	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.302413 (rank : 86)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	191	Target Neighborhood Hits	351	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

HAPIP_HUMAN
NC score	0.292826 (rank : 87)	θ value	0.0431538 (rank : 100)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	78
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

LBC_HUMAN
NC score	0.292804 (rank : 88)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	191	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_HUMAN
NC score	0.289733 (rank : 89)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	191	Target Neighborhood Hits	142	Shared Neighborhood Hits	54
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

PKHG4_HUMAN
NC score	0.239057 (rank : 90)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	191	Target Neighborhood Hits	200	Shared Neighborhood Hits	51
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PKHA6_MOUSE
NC score	0.181504 (rank : 91)	θ value	0.0113563 (rank : 89)
Query Neighborhood Hits	191	Target Neighborhood Hits	591	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
NC score	0.177411 (rank : 92)	θ value	0.0252991 (rank : 98)
Query Neighborhood Hits	191	Target Neighborhood Hits	556	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK2_HUMAN
NC score	0.162120 (rank : 93)	θ value	0.0330416 (rank : 99)
Query Neighborhood Hits	191	Target Neighborhood Hits	101	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PKHA4_MOUSE
NC score	0.160624 (rank : 94)	θ value	0.0148317 (rank : 94)
Query Neighborhood Hits	191	Target Neighborhood Hits	202	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH4_HUMAN
NC score	0.158436 (rank : 95)	θ value	0.000602161 (rank : 80)
Query Neighborhood Hits	191	Target Neighborhood Hits	135	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PKHF2_MOUSE
NC score	0.158162 (rank : 96)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	191	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.157683 (rank : 97)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	191	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

CYH4_MOUSE
NC score	0.157440 (rank : 98)	θ value	0.000602161 (rank : 81)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	51
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PLEK2_MOUSE
NC score	0.155962 (rank : 99)	θ value	0.0431538 (rank : 101)
Query Neighborhood Hits	191	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_MOUSE
NC score	0.155775 (rank : 100)	θ value	0.0961366 (rank : 103)
Query Neighborhood Hits	191	Target Neighborhood Hits	109	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

CYH3_MOUSE
NC score	0.154873 (rank : 101)	θ value	0.00175202 (rank : 84)
Query Neighborhood Hits	191	Target Neighborhood Hits	148	Shared Neighborhood Hits	55
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

PLEK_HUMAN
NC score	0.152689 (rank : 102)	θ value	0.0961366 (rank : 102)
Query Neighborhood Hits	191	Target Neighborhood Hits	110	Shared Neighborhood Hits	46
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHA4_HUMAN
NC score	0.149422 (rank : 103)	θ value	0.0252991 (rank : 97)
Query Neighborhood Hits	191	Target Neighborhood Hits	283	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHF1_HUMAN
NC score	0.146712 (rank : 104)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	191	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.145083 (rank : 105)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

CYH3_HUMAN
NC score	0.144486 (rank : 106)	θ value	0.00390308 (rank : 87)
Query Neighborhood Hits	191	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH2_HUMAN
NC score	0.144147 (rank : 107)	θ value	0.00390308 (rank : 85)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	55
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.143977 (rank : 108)	θ value	0.00390308 (rank : 86)
Query Neighborhood Hits	191	Target Neighborhood Hits	171	Shared Neighborhood Hits	54
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH1_HUMAN
NC score	0.141891 (rank : 109)	θ value	0.0148317 (rank : 92)
Query Neighborhood Hits	191	Target Neighborhood Hits	184	Shared Neighborhood Hits	60
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

DAPP1_MOUSE
NC score	0.139657 (rank : 110)	θ value	0.00035302 (rank : 77)
Query Neighborhood Hits	191	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CYH1_MOUSE
NC score	0.139531 (rank : 111)	θ value	0.0148317 (rank : 93)
Query Neighborhood Hits	191	Target Neighborhood Hits	176	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DAPP1_HUMAN
NC score	0.138244 (rank : 112)	θ value	0.000461057 (rank : 78)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA5_HUMAN
NC score	0.135760 (rank : 113)	θ value	0.365318 (rank : 105)
Query Neighborhood Hits	191	Target Neighborhood Hits	455	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

SWP70_HUMAN
NC score	0.131992 (rank : 114)	θ value	1.43324e-05 (rank : 74)
Query Neighborhood Hits	191	Target Neighborhood Hits	973	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

DUET_HUMAN
NC score	0.129826 (rank : 115)	θ value	0.000602161 (rank : 82)
Query Neighborhood Hits	191	Target Neighborhood Hits	1220	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

SWP70_MOUSE
NC score	0.126984 (rank : 116)	θ value	2.44474e-05 (rank : 75)
Query Neighborhood Hits	191	Target Neighborhood Hits	1097	Shared Neighborhood Hits	84
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RHG25_HUMAN
NC score	0.125255 (rank : 117)	θ value	0.0113563 (rank : 90)
Query Neighborhood Hits	191	Target Neighborhood Hits	550	Shared Neighborhood Hits	74
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
NC score	0.125147 (rank : 118)	θ value	0.0113563 (rank : 91)
Query Neighborhood Hits	191	Target Neighborhood Hits	492	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SH3K1_HUMAN
NC score	0.124116 (rank : 119)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	191	Target Neighborhood Hits	341	Shared Neighborhood Hits	30
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

3BP2_MOUSE
NC score	0.118238 (rank : 120)	θ value	1.06291 (rank : 118)
Query Neighborhood Hits	191	Target Neighborhood Hits	142	Shared Neighborhood Hits	42
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

NCF1_HUMAN
NC score	0.117449 (rank : 121)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

TRIO_HUMAN
NC score	0.117227 (rank : 122)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	191	Target Neighborhood Hits	1580	Shared Neighborhood Hits	91
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

3BP2_HUMAN
NC score	0.116515 (rank : 123)	θ value	1.38821 (rank : 123)
Query Neighborhood Hits	191	Target Neighborhood Hits	296	Shared Neighborhood Hits	44
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SH3K1_MOUSE
NC score	0.116368 (rank : 124)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_HUMAN
NC score	0.115960 (rank : 125)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	191	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.115898 (rank : 126)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	191	Target Neighborhood Hits	336	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SRBS1_MOUSE
NC score	0.113130 (rank : 127)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	191	Target Neighborhood Hits	409	Shared Neighborhood Hits	28
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF1_MOUSE
NC score	0.111691 (rank : 128)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CNKR1_HUMAN
NC score	0.111605 (rank : 129)	θ value	0.62314 (rank : 110)
Query Neighborhood Hits	191	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

SRBS1_HUMAN
NC score	0.108715 (rank : 130)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	191	Target Neighborhood Hits	396	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCK1_HUMAN
NC score	0.107697 (rank : 131)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	191	Target Neighborhood Hits	312	Shared Neighborhood Hits	28
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCF2_HUMAN
NC score	0.107642 (rank : 132)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	191	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VINEX_HUMAN
NC score	0.104462 (rank : 133)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	191	Target Neighborhood Hits	270	Shared Neighborhood Hits	25
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCK2_HUMAN
NC score	0.103800 (rank : 134)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

VINEX_MOUSE
NC score	0.103776 (rank : 135)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	191	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GRAP_HUMAN
NC score	0.100276 (rank : 136)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	25
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PKHA2_MOUSE
NC score	0.099995 (rank : 137)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	191	Target Neighborhood Hits	116	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

GRAP_MOUSE
NC score	0.099521 (rank : 138)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	191	Target Neighborhood Hits	309	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PKHA1_HUMAN
NC score	0.094142 (rank : 139)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	191	Target Neighborhood Hits	127	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ZFY28_HUMAN
NC score	0.093743 (rank : 140)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

PKHA1_MOUSE
NC score	0.092486 (rank : 141)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	191	Target Neighborhood Hits	120	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ZFYV9_HUMAN
NC score	0.092161 (rank : 142)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	14
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PKHA2_HUMAN
NC score	0.091886 (rank : 143)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	191	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

STAC_HUMAN
NC score	0.091677 (rank : 144)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	191	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF4_MOUSE
NC score	0.090618 (rank : 145)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_HUMAN
NC score	0.090502 (rank : 146)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	191	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRB2_HUMAN
NC score	0.089277 (rank : 147)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	23
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.089229 (rank : 148)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	191	Target Neighborhood Hits	312	Shared Neighborhood Hits	23
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAC_MOUSE
NC score	0.088633 (rank : 149)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	191	Target Neighborhood Hits	268	Shared Neighborhood Hits	24
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ZFY16_MOUSE
NC score	0.086582 (rank : 150)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	191	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

STAC3_MOUSE
NC score	0.085872 (rank : 151)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	191	Target Neighborhood Hits	232	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.085068 (rank : 152)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	23
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ZFY21_MOUSE
NC score	0.084960 (rank : 153)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	191	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

C43BP_MOUSE
NC score	0.084927 (rank : 154)	θ value	1.38821 (rank : 124)
Query Neighborhood Hits	191	Target Neighborhood Hits	91	Shared Neighborhood Hits	36
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OSBL9_HUMAN
NC score	0.084763 (rank : 155)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	191	Target Neighborhood Hits	138	Shared Neighborhood Hits	46
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

ABI2_MOUSE
NC score	0.083761 (rank : 156)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ZFY16_HUMAN
NC score	0.083740 (rank : 157)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.082980 (rank : 158)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	191	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ABI2_HUMAN
NC score	0.082963 (rank : 159)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

HCLS1_HUMAN
NC score	0.082640 (rank : 160)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	191	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PLCG1_MOUSE
NC score	0.082632 (rank : 161)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	191	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

HCLS1_MOUSE
NC score	0.081440 (rank : 162)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	191	Target Neighborhood Hits	329	Shared Neighborhood Hits	26
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

TCGAP_MOUSE
NC score	0.081315 (rank : 163)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	191	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

GRAP2_MOUSE
NC score	0.081043 (rank : 164)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	191	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PLCG1_HUMAN
NC score	0.080952 (rank : 165)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

GRAP2_HUMAN
NC score	0.080789 (rank : 166)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	191	Target Neighborhood Hits	304	Shared Neighborhood Hits	22
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ABI1_MOUSE
NC score	0.080601 (rank : 167)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	191	Target Neighborhood Hits	246	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

C43BP_HUMAN
NC score	0.080092 (rank : 168)	θ value	3.0926 (rank : 147)
Query Neighborhood Hits	191	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OSB11_MOUSE
NC score	0.080006 (rank : 169)	θ value	0.0252991 (rank : 96)
Query Neighborhood Hits	191	Target Neighborhood Hits	71	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

STAM1_HUMAN
NC score	0.079758 (rank : 170)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	191	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

TCGAP_HUMAN
NC score	0.079724 (rank : 171)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	191	Target Neighborhood Hits	872	Shared Neighborhood Hits	44
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

STAM1_MOUSE
NC score	0.079290 (rank : 172)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	191	Target Neighborhood Hits	273	Shared Neighborhood Hits	21
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SRC8_HUMAN
NC score	0.079155 (rank : 173)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	191	Target Neighborhood Hits	269	Shared Neighborhood Hits	25
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

CRKL_HUMAN
NC score	0.078986 (rank : 174)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	191	Target Neighborhood Hits	313	Shared Neighborhood Hits	22
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

PPIP1_HUMAN
NC score	0.078902 (rank : 175)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	191	Target Neighborhood Hits	389	Shared Neighborhood Hits	37
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

RHG04_HUMAN
NC score	0.078026 (rank : 176)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PKHA3_MOUSE
NC score	0.077795 (rank : 177)	θ value	1.06291 (rank : 120)
Query Neighborhood Hits	191	Target Neighborhood Hits	67	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

OSB11_HUMAN
NC score	0.077655 (rank : 178)	θ value	0.0252991 (rank : 95)
Query Neighborhood Hits	191	Target Neighborhood Hits	60	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

CRKL_MOUSE
NC score	0.077492 (rank : 179)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SRC8_MOUSE
NC score	0.077248 (rank : 180)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	191	Target Neighborhood Hits	292	Shared Neighborhood Hits	23
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

BI2L1_HUMAN
NC score	0.076440 (rank : 181)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	191	Target Neighborhood Hits	156	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ABI1_HUMAN
NC score	0.076367 (rank : 182)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	191	Target Neighborhood Hits	257	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

STAM2_MOUSE
NC score	0.076090 (rank : 183)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	191	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.075779 (rank : 184)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	191	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SH3G3_MOUSE
NC score	0.075383 (rank : 185)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	191	Target Neighborhood Hits	236	Shared Neighborhood Hits	23
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

CRK_MOUSE
NC score	0.075109 (rank : 186)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	191	Target Neighborhood Hits	314	Shared Neighborhood Hits	24
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G1_HUMAN
NC score	0.073890 (rank : 187)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

PPIP1_MOUSE
NC score	0.073557 (rank : 188)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	191	Target Neighborhood Hits	377	Shared Neighborhood Hits	32
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ABI3_HUMAN
NC score	0.073296 (rank : 189)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G3_HUMAN
NC score	0.073293 (rank : 190)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	191	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CRK_HUMAN
NC score	0.073206 (rank : 191)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	191	Target Neighborhood Hits	308	Shared Neighborhood Hits	23
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CNKR2_MOUSE
NC score	0.073095 (rank : 192)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	191	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.073002 (rank : 193)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	191	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

RBNS5_HUMAN
NC score	0.070981 (rank : 194)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

ABI3_MOUSE
NC score	0.070668 (rank : 195)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

HGS_MOUSE
NC score	0.070351 (rank : 196)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	191	Target Neighborhood Hits	589	Shared Neighborhood Hits	26
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

SH3G2_HUMAN
NC score	0.070142 (rank : 197)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	27
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

HGS_HUMAN
NC score	0.070120 (rank : 198)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	191	Target Neighborhood Hits	517	Shared Neighborhood Hits	25
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

SH3G1_MOUSE
NC score	0.069838 (rank : 199)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	191	Target Neighborhood Hits	291	Shared Neighborhood Hits	23
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

RBNS5_MOUSE
NC score	0.069222 (rank : 200)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

CT152_HUMAN
NC score	0.069171 (rank : 201)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

DGKH_HUMAN
NC score	0.069150 (rank : 202)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	191	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

SH3G2_MOUSE
NC score	0.068692 (rank : 203)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	191	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

FYV1_HUMAN
NC score	0.068393 (rank : 204)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	191	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

SHAN2_MOUSE
NC score	0.067524 (rank : 205)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	191	Target Neighborhood Hits	446	Shared Neighborhood Hits	30
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

FYV1_MOUSE
NC score	0.067365 (rank : 206)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

SRGP1_HUMAN
NC score	0.067006 (rank : 207)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	191	Target Neighborhood Hits	390	Shared Neighborhood Hits	33
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

PLCG2_HUMAN
NC score	0.066974 (rank : 208)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	191	Target Neighborhood Hits	280	Shared Neighborhood Hits	21
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NOXO1_MOUSE
NC score	0.066763 (rank : 209)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	191	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SRGP2_MOUSE
NC score	0.065447 (rank : 210)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	31
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

FNBP2_HUMAN
NC score	0.065361 (rank : 211)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	191	Target Neighborhood Hits	432	Shared Neighborhood Hits	37
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

PSD3_HUMAN
NC score	0.065341 (rank : 212)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	191	Target Neighborhood Hits	75	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

SRGP2_HUMAN
NC score	0.065045 (rank : 213)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	191	Target Neighborhood Hits	331	Shared Neighborhood Hits	31
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

DBNL_HUMAN
NC score	0.064928 (rank : 214)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	191	Target Neighborhood Hits	244	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

RHG26_HUMAN
NC score	0.064590 (rank : 215)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	191	Target Neighborhood Hits	281	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

OSTF1_HUMAN
NC score	0.064357 (rank : 216)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	191	Target Neighborhood Hits	466	Shared Neighborhood Hits	22
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

AHI1_HUMAN
NC score	0.064337 (rank : 217)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	191	Target Neighborhood Hits	537	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

PKHB1_HUMAN
NC score	0.064055 (rank : 218)	θ value	0.813845 (rank : 116)
Query Neighborhood Hits	191	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

RUFY2_MOUSE
NC score	0.063607 (rank : 219)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	191	Target Neighborhood Hits	820	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

OSTF1_MOUSE
NC score	0.063589 (rank : 220)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	191	Target Neighborhood Hits	467	Shared Neighborhood Hits	22
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

BI2L1_MOUSE
NC score	0.062865 (rank : 221)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	191	Target Neighborhood Hits	197	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

AHI1_MOUSE
NC score	0.062635 (rank : 222)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	191	Target Neighborhood Hits	496	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

DBNL_MOUSE
NC score	0.061905 (rank : 223)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	191	Target Neighborhood Hits	306	Shared Neighborhood Hits	23
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

P85A_HUMAN
NC score	0.061808 (rank : 224)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	191	Target Neighborhood Hits	479	Shared Neighborhood Hits	32
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PKHA3_HUMAN
NC score	0.061191 (rank : 225)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	191	Target Neighborhood Hits	66	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

ZFY19_HUMAN
NC score	0.061142 (rank : 226)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	191	Target Neighborhood Hits	206	Shared Neighborhood Hits	19
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

LASP1_HUMAN
NC score	0.060723 (rank : 227)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CEND2_HUMAN
NC score	0.060257 (rank : 228)	θ value	0.47712 (rank : 107)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	43
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

IQEC3_HUMAN
NC score	0.060216 (rank : 229)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

RUFY2_HUMAN
NC score	0.060140 (rank : 230)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	191	Target Neighborhood Hits	1208	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PSD4_MOUSE
NC score	0.059819 (rank : 231)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	191	Target Neighborhood Hits	78	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RUFY1_HUMAN
NC score	0.059681 (rank : 232)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	191	Target Neighborhood Hits	848	Shared Neighborhood Hits	51
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

CHIN_MOUSE
NC score	0.059440 (rank : 233)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	191	Target Neighborhood Hits	229	Shared Neighborhood Hits	16
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

NEBL_HUMAN
NC score	0.059257 (rank : 234)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	191	Target Neighborhood Hits	457	Shared Neighborhood Hits	36
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

CHIN_HUMAN
NC score	0.059243 (rank : 235)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	16
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

NPHP1_MOUSE
NC score	0.059174 (rank : 236)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	191	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

LASP1_MOUSE
NC score	0.059112 (rank : 237)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	191	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

P85A_MOUSE
NC score	0.058307 (rank : 238)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	32
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

NOXO1_HUMAN
NC score	0.057738 (rank : 239)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	191	Target Neighborhood Hits	100	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PACN3_MOUSE
NC score	0.057729 (rank : 240)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	191	Target Neighborhood Hits	380	Shared Neighborhood Hits	36
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PSD4_HUMAN
NC score	0.057687 (rank : 241)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	191	Target Neighborhood Hits	178	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

RUFY1_MOUSE
NC score	0.056706 (rank : 242)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	191	Target Neighborhood Hits	765	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

ZFY19_MOUSE
NC score	0.056656 (rank : 243)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	191	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

CHIO_MOUSE
NC score	0.056371 (rank : 244)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	191	Target Neighborhood Hits	130	Shared Neighborhood Hits	14
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

PACN2_MOUSE
NC score	0.055976 (rank : 245)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	191	Target Neighborhood Hits	382	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PEX13_MOUSE
NC score	0.055922 (rank : 246)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	191	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CHIO_HUMAN
NC score	0.055841 (rank : 247)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	191	Target Neighborhood Hits	220	Shared Neighborhood Hits	16
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

IQEC3_MOUSE
NC score	0.055804 (rank : 248)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	191	Target Neighborhood Hits	274	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

PACN2_HUMAN
NC score	0.055516 (rank : 249)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	191	Target Neighborhood Hits	339	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
NC score	0.055461 (rank : 250)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	191	Target Neighborhood Hits	385	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

CT152_MOUSE
NC score	0.055306 (rank : 251)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	191	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

P85B_HUMAN
NC score	0.054977 (rank : 252)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	191	Target Neighborhood Hits	543	Shared Neighborhood Hits	34
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CENA1_HUMAN
NC score	0.054932 (rank : 253)	θ value	0.62314 (rank : 109)
Query Neighborhood Hits	191	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

EEA1_MOUSE
NC score	0.054636 (rank : 254)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	191	Target Neighborhood Hits	1637	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MYO10_HUMAN
NC score	0.054495 (rank : 255)	θ value	0.00869519 (rank : 88)
Query Neighborhood Hits	191	Target Neighborhood Hits	920	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

P85B_MOUSE
NC score	0.054336 (rank : 256)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	191	Target Neighborhood Hits	519	Shared Neighborhood Hits	39
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

EEA1_HUMAN
NC score	0.054327 (rank : 257)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	191	Target Neighborhood Hits	1796	Shared Neighborhood Hits	67
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

REPS1_MOUSE
NC score	0.054231 (rank : 258)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	191	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

ANM2_HUMAN
NC score	0.054186 (rank : 259)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

GBF1_HUMAN
NC score	0.054064 (rank : 260)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	191	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

PEX13_HUMAN
NC score	0.053685 (rank : 261)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	191	Target Neighborhood Hits	128	Shared Neighborhood Hits	17
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

LMO7_HUMAN
NC score	0.053667 (rank : 262)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	191	Target Neighborhood Hits	507	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

ZFYV1_HUMAN
NC score	0.053414 (rank : 263)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

BIG2_HUMAN
NC score	0.053405 (rank : 264)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	191	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

REPS2_HUMAN
NC score	0.053134 (rank : 265)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	191	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

BCAR1_MOUSE
NC score	0.053020 (rank : 266)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	191	Target Neighborhood Hits	438	Shared Neighborhood Hits	24
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

REPS2_MOUSE
NC score	0.052912 (rank : 267)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	191	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

ALS2_MOUSE
NC score	0.052682 (rank : 268)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	191	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CT032_HUMAN
NC score	0.052396 (rank : 269)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

BIG1_HUMAN
NC score	0.052305 (rank : 270)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	191	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

ZFYV1_MOUSE
NC score	0.052236 (rank : 271)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	191	Target Neighborhood Hits	153	Shared Neighborhood Hits	16
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

RIMB2_HUMAN
NC score	0.051103 (rank : 272)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	191	Target Neighborhood Hits	263	Shared Neighborhood Hits	22
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ANM2_MOUSE
NC score	0.050910 (rank : 273)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RIMB2_MOUSE
NC score	0.050806 (rank : 274)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	191	Target Neighborhood Hits	246	Shared Neighborhood Hits	20
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PKHB1_MOUSE
NC score	0.050581 (rank : 275)	θ value	3.0926 (rank : 152)
Query Neighborhood Hits	191	Target Neighborhood Hits	47	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

CASL_HUMAN
NC score	0.050507 (rank : 276)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	191	Target Neighborhood Hits	259	Shared Neighborhood Hits	21
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PACN1_HUMAN
NC score	0.050301 (rank : 277)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	191	Target Neighborhood Hits	320	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SHAN1_HUMAN
NC score	0.050157 (rank : 278)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	191	Target Neighborhood Hits	1041	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EP15_HUMAN
NC score	0.050134 (rank : 279)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	191	Target Neighborhood Hits	1021	Shared Neighborhood Hits	48
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

OSBP1_HUMAN
NC score	0.049041 (rank : 280)	θ value	4.03905 (rank : 159)
Query Neighborhood Hits	191	Target Neighborhood Hits	180	Shared Neighborhood Hits	43
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

AZI1_HUMAN
NC score	0.047101 (rank : 281)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	191	Target Neighborhood Hits	1000	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CCD96_MOUSE
NC score	0.045890 (rank : 282)	θ value	2.36792 (rank : 137)
Query Neighborhood Hits	191	Target Neighborhood Hits	704	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

AZI1_MOUSE
NC score	0.044641 (rank : 283)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	191	Target Neighborhood Hits	990	Shared Neighborhood Hits	47
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

CENA2_HUMAN
NC score	0.043776 (rank : 284)	θ value	2.36792 (rank : 138)
Query Neighborhood Hits	191	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ODO1_MOUSE
NC score	0.038545 (rank : 285)	θ value	1.81305 (rank : 130)
Query Neighborhood Hits	191	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q60597, Q80Y57, Q8K2Z3	Gene names	Ogdh
Domain Architecture
Description	2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).

SPTB2_HUMAN
NC score	0.037511 (rank : 286)	θ value	1.06291 (rank : 122)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	55
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ODO1_HUMAN
NC score	0.037023 (rank : 287)	θ value	2.36792 (rank : 144)
Query Neighborhood Hits	191	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q02218	Gene names	OGDH
Domain Architecture
Description	2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).

BLNK_MOUSE
NC score	0.036617 (rank : 288)	θ value	6.88961 (rank : 166)
Query Neighborhood Hits	191	Target Neighborhood Hits	296	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CJ118_MOUSE
NC score	0.035164 (rank : 289)	θ value	3.0926 (rank : 148)
Query Neighborhood Hits	191	Target Neighborhood Hits	1132	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

PCNT_HUMAN
NC score	0.034513 (rank : 290)	θ value	4.03905 (rank : 160)
Query Neighborhood Hits	191	Target Neighborhood Hits	1551	Shared Neighborhood Hits	55
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

CP250_MOUSE
NC score	0.034371 (rank : 291)	θ value	0.47712 (rank : 108)
Query Neighborhood Hits	191	Target Neighborhood Hits	1583	Shared Neighborhood Hits	53
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

KTN1_HUMAN
NC score	0.033425 (rank : 292)	θ value	0.813845 (rank : 113)
Query Neighborhood Hits	191	Target Neighborhood Hits	1197	Shared Neighborhood Hits	52
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

AKAP9_HUMAN
NC score	0.033188 (rank : 293)	θ value	0.813845 (rank : 111)
Query Neighborhood Hits	191	Target Neighborhood Hits	1710	Shared Neighborhood Hits	56
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

TPR_HUMAN
NC score	0.031403 (rank : 294)	θ value	4.03905 (rank : 161)
Query Neighborhood Hits	191	Target Neighborhood Hits	1921	Shared Neighborhood Hits	67
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

NAF1_MOUSE
NC score	0.030866 (rank : 295)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	191	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

HOOK3_MOUSE
NC score	0.030794 (rank : 296)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	191	Target Neighborhood Hits	1007	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

CROCC_HUMAN
NC score	0.030670 (rank : 297)	θ value	2.36792 (rank : 139)
Query Neighborhood Hits	191	Target Neighborhood Hits	1409	Shared Neighborhood Hits	51
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

REST_HUMAN
NC score	0.030233 (rank : 298)	θ value	1.06291 (rank : 121)
Query Neighborhood Hits	191	Target Neighborhood Hits	1605	Shared Neighborhood Hits	55
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

GCC2_MOUSE
NC score	0.029823 (rank : 299)	θ value	0.813845 (rank : 112)
Query Neighborhood Hits	191	Target Neighborhood Hits	1619	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

STAP1_MOUSE
NC score	0.029788 (rank : 300)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	191	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JM90, Q3TRM1, Q6PES6	Gene names	Stap1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1).

ZN318_MOUSE
NC score	0.029700 (rank : 301)	θ value	1.81305 (rank : 134)
Query Neighborhood Hits	191	Target Neighborhood Hits	642	Shared Neighborhood Hits	31
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

TBCD1_MOUSE
NC score	0.027696 (rank : 302)	θ value	0.365318 (rank : 106)
Query Neighborhood Hits	191	Target Neighborhood Hits	241	Shared Neighborhood Hits	18
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

CROCC_MOUSE
NC score	0.027528 (rank : 303)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	191	Target Neighborhood Hits	1460	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

MYH6_MOUSE
NC score	0.026678 (rank : 304)	θ value	2.36792 (rank : 143)
Query Neighborhood Hits	191	Target Neighborhood Hits	1501	Shared Neighborhood Hits	55
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

CJ118_HUMAN
NC score	0.026590 (rank : 305)	θ value	0.21417 (rank : 104)
Query Neighborhood Hits	191	Target Neighborhood Hits	937	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

TBCD1_HUMAN
NC score	0.026339 (rank : 306)	θ value	1.38821 (rank : 127)
Query Neighborhood Hits	191	Target Neighborhood Hits	276	Shared Neighborhood Hits	22
SwissProt Accessions	Q86TI0, Q96K82, Q9UPP4	Gene names	TBC1D1, KIAA1108
Domain Architecture
Description	TBC1 domain family member 1.

CENA2_MOUSE
NC score	0.026190 (rank : 307)	θ value	8.99809 (rank : 179)
Query Neighborhood Hits	191	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

MYH7_HUMAN
NC score	0.025838 (rank : 308)	θ value	3.0926 (rank : 151)
Query Neighborhood Hits	191	Target Neighborhood Hits	1559	Shared Neighborhood Hits	56
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH6_HUMAN
NC score	0.025078 (rank : 309)	θ value	3.0926 (rank : 150)
Query Neighborhood Hits	191	Target Neighborhood Hits	1426	Shared Neighborhood Hits	52
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MORC3_HUMAN
NC score	0.024957 (rank : 310)	θ value	3.0926 (rank : 149)
Query Neighborhood Hits	191	Target Neighborhood Hits	489	Shared Neighborhood Hits	34
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

DBND2_HUMAN
NC score	0.024509 (rank : 311)	θ value	1.38821 (rank : 125)
Query Neighborhood Hits	191	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQY9, Q9BQZ0, Q9BVL1, Q9H1F6, Q9NWZ0, Q9NY07, Q9NZ31	Gene names	DBNDD2, C20orf35
Domain Architecture
Description	Dysbindin domain-containing protein 2 (HSMNP1).

MYO5C_HUMAN
NC score	0.024047 (rank : 312)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	191	Target Neighborhood Hits	1206	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

BPAEA_HUMAN
NC score	0.023891 (rank : 313)	θ value	8.99809 (rank : 178)
Query Neighborhood Hits	191	Target Neighborhood Hits	1369	Shared Neighborhood Hits	45
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

PDE1B_HUMAN
NC score	0.023884 (rank : 314)	θ value	1.81305 (rank : 131)
Query Neighborhood Hits	191	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

MYH14_HUMAN
NC score	0.023338 (rank : 315)	θ value	1.06291 (rank : 119)
Query Neighborhood Hits	191	Target Neighborhood Hits	995	Shared Neighborhood Hits	44
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PDE1B_MOUSE
NC score	0.022554 (rank : 316)	θ value	1.81305 (rank : 132)
Query Neighborhood Hits	191	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

BPA1_MOUSE
NC score	0.022428 (rank : 317)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	191	Target Neighborhood Hits	1477	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

NOLC1_HUMAN
NC score	0.020969 (rank : 318)	θ value	0.813845 (rank : 114)
Query Neighborhood Hits	191	Target Neighborhood Hits	452	Shared Neighborhood Hits	11
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PDE1A_MOUSE
NC score	0.019939 (rank : 319)	θ value	0.813845 (rank : 115)
Query Neighborhood Hits	191	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

OLR1_MOUSE
NC score	0.019431 (rank : 320)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	191	Target Neighborhood Hits	596	Shared Neighborhood Hits	31
SwissProt Accessions	Q9EQ09	Gene names	Olr1, Lox1
Domain Architecture	No domain graphic available
Description	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-type oxidized LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (Lectin-like oxLDL receptor 1) (LOX-1) [Contains: Oxidized low-density lipoprotein receptor 1, soluble form].

PDE1A_HUMAN
NC score	0.019249 (rank : 321)	θ value	1.38821 (rank : 126)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

SRRM1_HUMAN
NC score	0.019240 (rank : 322)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	191	Target Neighborhood Hits	690	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

ZC3H3_MOUSE
NC score	0.019161 (rank : 323)	θ value	0.813845 (rank : 117)
Query Neighborhood Hits	191	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

CS016_HUMAN
NC score	0.018768 (rank : 324)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	10
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DGLA_HUMAN
NC score	0.018272 (rank : 325)	θ value	2.36792 (rank : 140)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4D2, Q6WQJ0	Gene names	NSDDR, C11orf11, KIAA0659
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase alpha (EC 3.1.1.-) (DGL-alpha) (Neural stem cell-derived dendrite regulator).

SYCP2_HUMAN
NC score	0.017811 (rank : 326)	θ value	2.36792 (rank : 145)
Query Neighborhood Hits	191	Target Neighborhood Hits	230	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX26, O75763, Q5JX11, Q9NTX8, Q9UG27	Gene names	SYCP2, SCP2
Domain Architecture	No domain graphic available
Description	Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (hsSCP2).

BAZ1B_HUMAN
NC score	0.017176 (rank : 327)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	191	Target Neighborhood Hits	701	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

CENPQ_MOUSE
NC score	0.016779 (rank : 328)	θ value	8.99809 (rank : 180)
Query Neighborhood Hits	191	Target Neighborhood Hits	160	Shared Neighborhood Hits	16
SwissProt Accessions	Q9CPQ5, Q8C2G4, Q8VEF8, Q9CX70	Gene names	Cenpq
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

DGLA_MOUSE
NC score	0.016761 (rank : 329)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	191	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q6WQJ1, Q6ZQ76	Gene names	Nsddr, Kiaa0659
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase alpha (EC 3.1.1.-) (DGL-alpha) (Neural stem cell-derived dendrite regulator).

PDE1C_HUMAN
NC score	0.016302 (rank : 330)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
NC score	0.016217 (rank : 331)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	191	Target Neighborhood Hits	161	Shared Neighborhood Hits	9
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

THAP4_MOUSE
NC score	0.015087 (rank : 332)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	191	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

LRSM1_MOUSE
NC score	0.015037 (rank : 333)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	191	Target Neighborhood Hits	874	Shared Neighborhood Hits	33
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

ANK2_HUMAN
NC score	0.014713 (rank : 334)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	191	Target Neighborhood Hits	1615	Shared Neighborhood Hits	44
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

TRPM3_HUMAN
NC score	0.013802 (rank : 335)	θ value	1.81305 (rank : 133)
Query Neighborhood Hits	191	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

BCL9_MOUSE
NC score	0.012787 (rank : 336)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	191	Target Neighborhood Hits	770	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

AFF4_MOUSE
NC score	0.010868 (rank : 337)	θ value	2.36792 (rank : 135)
Query Neighborhood Hits	191	Target Neighborhood Hits	581	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

SNX8_HUMAN
NC score	0.010073 (rank : 338)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	191	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5X2, Q96I67	Gene names	SNX8
Domain Architecture
Description	Sorting nexin-8.

FA53C_MOUSE
NC score	0.009473 (rank : 339)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	191	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BXQ8, Q3U4J2	Gene names	Fam53c
Domain Architecture	No domain graphic available
Description	Protein FAM53C.

CDCA7_MOUSE
NC score	0.008427 (rank : 340)	θ value	6.88961 (rank : 167)
Query Neighborhood Hits	191	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D0M2, Q3TIS1, Q3U511, Q6NZE5, Q8C1A0	Gene names	Cdca7
Domain Architecture	No domain graphic available
Description	Cell division cycle-associated protein 7.

AN32B_MOUSE
NC score	0.007744 (rank : 341)	θ value	2.36792 (rank : 136)
Query Neighborhood Hits	191	Target Neighborhood Hits	236	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

GMEB2_MOUSE
NC score	0.007304 (rank : 342)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	191	Target Neighborhood Hits	64	Shared Neighborhood Hits	7
SwissProt Accessions	P58929, Q6PCY0	Gene names	Gmeb2
Domain Architecture	No domain graphic available
Description	Glucocorticoid modulatory element-binding protein 2 (GMEB-2).

DMRT1_HUMAN
NC score	0.007106 (rank : 343)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	191	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5R6, Q8IW77	Gene names	DMRT1, DMT1
Domain Architecture
Description	Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1).

SCN8A_HUMAN
NC score	0.003094 (rank : 344)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	191	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CHD8_HUMAN
NC score	0.001402 (rank : 345)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCK8, Q68DQ0, Q8N3Z9, Q8NCY4, Q8TBR9, Q96F26	Gene names	CHD8, HELSNF1, KIAA1564
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 8 (EC 3.6.1.-) (ATP- dependent helicase CHD8) (CHD-8) (Helicase with SNF2 domain 1).

CSPG2_MOUSE
NC score	-0.001366 (rank : 346)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	191	Target Neighborhood Hits	711	Shared Neighborhood Hits	8
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

TLR5_MOUSE
NC score	-0.001696 (rank : 347)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	191	Target Neighborhood Hits	287	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

NUAK1_MOUSE
NC score	-0.007080 (rank : 348)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	191	Target Neighborhood Hits	881	Shared Neighborhood Hits	5
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

ZBT11_HUMAN
NC score	-0.007393 (rank : 349)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	191	Target Neighborhood Hits	873	Shared Neighborhood Hits	5
SwissProt Accessions	O95625	Gene names	ZBTB11
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 11.

MAZ_MOUSE
NC score	-0.007577 (rank : 350)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	191	Target Neighborhood Hits	745	Shared Neighborhood Hits	3
SwissProt Accessions	P56671, Q9R1W0	Gene names	Maz
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1).