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Network neighborhood for query Sequence : CRK_MOUSE

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CRK_MOUSE
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CRK_MOUSE
θ value	4.11978e-162 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	314	Target Neighborhood Hits	314	Shared Neighborhood Hits	314
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
θ value	2.49938e-159 (rank : 2)	NC score	0.996582 (rank : 2)
Query Neighborhood Hits	314	Target Neighborhood Hits	308	Shared Neighborhood Hits	304
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
θ value	2.38316e-93 (rank : 3)	NC score	0.961763 (rank : 3)
Query Neighborhood Hits	314	Target Neighborhood Hits	313	Shared Neighborhood Hits	283
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	6.93392e-93 (rank : 4)	NC score	0.959286 (rank : 4)
Query Neighborhood Hits	314	Target Neighborhood Hits	307	Shared Neighborhood Hits	284
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

GRAP_HUMAN
θ value	2.5182e-18 (rank : 5)	NC score	0.793671 (rank : 5)
Query Neighborhood Hits	314	Target Neighborhood Hits	307	Shared Neighborhood Hits	275
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	1.99529e-15 (rank : 6)	NC score	0.786682 (rank : 8)
Query Neighborhood Hits	314	Target Neighborhood Hits	309	Shared Neighborhood Hits	274
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	2.60593e-15 (rank : 7)	NC score	0.792479 (rank : 7)
Query Neighborhood Hits	314	Target Neighborhood Hits	310	Shared Neighborhood Hits	272
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	2.60593e-15 (rank : 8)	NC score	0.792510 (rank : 6)
Query Neighborhood Hits	314	Target Neighborhood Hits	312	Shared Neighborhood Hits	274
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

DNMBP_HUMAN
θ value	8.67504e-11 (rank : 9)	NC score	0.494605 (rank : 39)
Query Neighborhood Hits	314	Target Neighborhood Hits	413	Shared Neighborhood Hits	193
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PLCG1_HUMAN
θ value	7.34386e-10 (rank : 10)	NC score	0.571124 (rank : 17)
Query Neighborhood Hits	314	Target Neighborhood Hits	293	Shared Neighborhood Hits	231
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	9.59137e-10 (rank : 11)	NC score	0.578368 (rank : 15)
Query Neighborhood Hits	314	Target Neighborhood Hits	314	Shared Neighborhood Hits	237
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV_HUMAN
θ value	4.76016e-09 (rank : 12)	NC score	0.578992 (rank : 14)
Query Neighborhood Hits	314	Target Neighborhood Hits	452	Shared Neighborhood Hits	250
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

NPHP1_MOUSE
θ value	6.21693e-09 (rank : 13)	NC score	0.575800 (rank : 16)
Query Neighborhood Hits	314	Target Neighborhood Hits	267	Shared Neighborhood Hits	191
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

VAV_MOUSE
θ value	4.0297e-08 (rank : 14)	NC score	0.560973 (rank : 19)
Query Neighborhood Hits	314	Target Neighborhood Hits	430	Shared Neighborhood Hits	245
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV3_HUMAN
θ value	6.87365e-08 (rank : 15)	NC score	0.559038 (rank : 20)
Query Neighborhood Hits	314	Target Neighborhood Hits	398	Shared Neighborhood Hits	244
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	6.87365e-08 (rank : 16)	NC score	0.556514 (rank : 21)
Query Neighborhood Hits	314	Target Neighborhood Hits	404	Shared Neighborhood Hits	242
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

CD2AP_HUMAN
θ value	1.53129e-07 (rank : 17)	NC score	0.583941 (rank : 13)
Query Neighborhood Hits	314	Target Neighborhood Hits	315	Shared Neighborhood Hits	193
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NPHP1_HUMAN
θ value	2.61198e-07 (rank : 18)	NC score	0.527125 (rank : 31)
Query Neighborhood Hits	314	Target Neighborhood Hits	288	Shared Neighborhood Hits	168
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

DNMBP_MOUSE
θ value	3.41135e-07 (rank : 19)	NC score	0.475437 (rank : 40)
Query Neighborhood Hits	314	Target Neighborhood Hits	435	Shared Neighborhood Hits	194
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MATK_HUMAN
θ value	5.81887e-07 (rank : 20)	NC score	0.226483 (rank : 238)
Query Neighborhood Hits	314	Target Neighborhood Hits	954	Shared Neighborhood Hits	160
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	7.59969e-07 (rank : 21)	NC score	0.225968 (rank : 239)
Query Neighborhood Hits	314	Target Neighborhood Hits	952	Shared Neighborhood Hits	161
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

ABL2_HUMAN
θ value	1.29631e-06 (rank : 22)	NC score	0.259483 (rank : 197)
Query Neighborhood Hits	314	Target Neighborhood Hits	1045	Shared Neighborhood Hits	198
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABL1_HUMAN
θ value	1.69304e-06 (rank : 23)	NC score	0.257913 (rank : 200)
Query Neighborhood Hits	314	Target Neighborhood Hits	1220	Shared Neighborhood Hits	208
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	1.69304e-06 (rank : 24)	NC score	0.257661 (rank : 201)
Query Neighborhood Hits	314	Target Neighborhood Hits	1178	Shared Neighborhood Hits	207
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CD2AP_MOUSE
θ value	2.21117e-06 (rank : 25)	NC score	0.569511 (rank : 18)
Query Neighborhood Hits	314	Target Neighborhood Hits	336	Shared Neighborhood Hits	194
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CSK_HUMAN
θ value	2.21117e-06 (rank : 26)	NC score	0.260721 (rank : 193)
Query Neighborhood Hits	314	Target Neighborhood Hits	1009	Shared Neighborhood Hits	217
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

GRB14_MOUSE
θ value	2.21117e-06 (rank : 27)	NC score	0.443836 (rank : 66)
Query Neighborhood Hits	314	Target Neighborhood Hits	149	Shared Neighborhood Hits	117
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

RHG04_HUMAN
θ value	2.21117e-06 (rank : 28)	NC score	0.315539 (rank : 148)
Query Neighborhood Hits	314	Target Neighborhood Hits	307	Shared Neighborhood Hits	166
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SHC1_HUMAN
θ value	2.21117e-06 (rank : 29)	NC score	0.458176 (rank : 52)
Query Neighborhood Hits	314	Target Neighborhood Hits	170	Shared Neighborhood Hits	125
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	2.21117e-06 (rank : 30)	NC score	0.460636 (rank : 50)
Query Neighborhood Hits	314	Target Neighborhood Hits	180	Shared Neighborhood Hits	126
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SRBS1_HUMAN
θ value	2.21117e-06 (rank : 31)	NC score	0.531429 (rank : 28)
Query Neighborhood Hits	314	Target Neighborhood Hits	396	Shared Neighborhood Hits	192
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CSK_MOUSE
θ value	2.88788e-06 (rank : 32)	NC score	0.261236 (rank : 192)
Query Neighborhood Hits	314	Target Neighborhood Hits	1009	Shared Neighborhood Hits	217
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

BCAR3_HUMAN
θ value	4.92598e-06 (rank : 33)	NC score	0.414451 (rank : 95)
Query Neighborhood Hits	314	Target Neighborhood Hits	129	Shared Neighborhood Hits	93
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	6.43352e-06 (rank : 34)	NC score	0.408315 (rank : 98)
Query Neighborhood Hits	314	Target Neighborhood Hits	127	Shared Neighborhood Hits	91
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

SH2D3_MOUSE
θ value	6.43352e-06 (rank : 35)	NC score	0.418256 (rank : 92)
Query Neighborhood Hits	314	Target Neighborhood Hits	174	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3K1_HUMAN
θ value	6.43352e-06 (rank : 36)	NC score	0.551431 (rank : 22)
Query Neighborhood Hits	314	Target Neighborhood Hits	341	Shared Neighborhood Hits	191
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ITSN1_MOUSE
θ value	8.40245e-06 (rank : 37)	NC score	0.355173 (rank : 126)
Query Neighborhood Hits	314	Target Neighborhood Hits	1669	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NCK1_HUMAN
θ value	8.40245e-06 (rank : 38)	NC score	0.727916 (rank : 9)
Query Neighborhood Hits	314	Target Neighborhood Hits	312	Shared Neighborhood Hits	272
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH23A_HUMAN
θ value	8.40245e-06 (rank : 39)	NC score	0.399880 (rank : 105)
Query Neighborhood Hits	314	Target Neighborhood Hits	149	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

VAV2_HUMAN
θ value	1.09739e-05 (rank : 40)	NC score	0.537824 (rank : 26)
Query Neighborhood Hits	314	Target Neighborhood Hits	453	Shared Neighborhood Hits	251
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

GRB14_HUMAN
θ value	1.43324e-05 (rank : 41)	NC score	0.429157 (rank : 80)
Query Neighborhood Hits	314	Target Neighborhood Hits	137	Shared Neighborhood Hits	113
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_MOUSE
θ value	1.43324e-05 (rank : 42)	NC score	0.418118 (rank : 93)
Query Neighborhood Hits	314	Target Neighborhood Hits	157	Shared Neighborhood Hits	116
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

ITSN1_HUMAN
θ value	1.43324e-05 (rank : 43)	NC score	0.352608 (rank : 128)
Query Neighborhood Hits	314	Target Neighborhood Hits	1757	Shared Neighborhood Hits	230
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

RASA1_HUMAN
θ value	1.43324e-05 (rank : 44)	NC score	0.432800 (rank : 76)
Query Neighborhood Hits	314	Target Neighborhood Hits	258	Shared Neighborhood Hits	137
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SHC3_MOUSE
θ value	1.43324e-05 (rank : 45)	NC score	0.470696 (rank : 43)
Query Neighborhood Hits	314	Target Neighborhood Hits	151	Shared Neighborhood Hits	123
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SPTA2_HUMAN
θ value	1.43324e-05 (rank : 46)	NC score	0.241456 (rank : 215)
Query Neighborhood Hits	314	Target Neighborhood Hits	888	Shared Neighborhood Hits	180
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SHC3_HUMAN
θ value	1.87187e-05 (rank : 47)	NC score	0.454972 (rank : 56)
Query Neighborhood Hits	314	Target Neighborhood Hits	155	Shared Neighborhood Hits	116
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

STAM2_MOUSE
θ value	1.87187e-05 (rank : 48)	NC score	0.515237 (rank : 35)
Query Neighborhood Hits	314	Target Neighborhood Hits	285	Shared Neighborhood Hits	195
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ARHG7_MOUSE
θ value	2.44474e-05 (rank : 49)	NC score	0.466350 (rank : 47)
Query Neighborhood Hits	314	Target Neighborhood Hits	396	Shared Neighborhood Hits	200
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

PTN11_HUMAN
θ value	2.44474e-05 (rank : 50)	NC score	0.281003 (rank : 180)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	2.44474e-05 (rank : 51)	NC score	0.281036 (rank : 179)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

SH2D3_HUMAN
θ value	2.44474e-05 (rank : 52)	NC score	0.410875 (rank : 97)
Query Neighborhood Hits	314	Target Neighborhood Hits	188	Shared Neighborhood Hits	99
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

GRB7_HUMAN
θ value	3.19293e-05 (rank : 53)	NC score	0.400309 (rank : 104)
Query Neighborhood Hits	314	Target Neighborhood Hits	156	Shared Neighborhood Hits	114
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

NCK2_HUMAN
θ value	3.19293e-05 (rank : 54)	NC score	0.719815 (rank : 10)
Query Neighborhood Hits	314	Target Neighborhood Hits	310	Shared Neighborhood Hits	271
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PTK6_HUMAN
θ value	3.19293e-05 (rank : 55)	NC score	0.239235 (rank : 219)
Query Neighborhood Hits	314	Target Neighborhood Hits	1020	Shared Neighborhood Hits	230
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SPTA1_MOUSE
θ value	3.19293e-05 (rank : 56)	NC score	0.236531 (rank : 225)
Query Neighborhood Hits	314	Target Neighborhood Hits	675	Shared Neighborhood Hits	160
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRBS1_MOUSE
θ value	3.19293e-05 (rank : 57)	NC score	0.523118 (rank : 32)
Query Neighborhood Hits	314	Target Neighborhood Hits	409	Shared Neighborhood Hits	189
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP2_HUMAN
θ value	4.1701e-05 (rank : 58)	NC score	0.710952 (rank : 12)
Query Neighborhood Hits	314	Target Neighborhood Hits	304	Shared Neighborhood Hits	268
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

YES_HUMAN
θ value	4.1701e-05 (rank : 59)	NC score	0.289528 (rank : 172)
Query Neighborhood Hits	314	Target Neighborhood Hits	1059	Shared Neighborhood Hits	254
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	4.1701e-05 (rank : 60)	NC score	0.290413 (rank : 169)
Query Neighborhood Hits	314	Target Neighborhood Hits	1052	Shared Neighborhood Hits	256
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

GRAP2_MOUSE
θ value	5.44631e-05 (rank : 61)	NC score	0.711882 (rank : 11)
Query Neighborhood Hits	314	Target Neighborhood Hits	297	Shared Neighborhood Hits	266
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PPIP1_HUMAN
θ value	5.44631e-05 (rank : 62)	NC score	0.496656 (rank : 37)
Query Neighborhood Hits	314	Target Neighborhood Hits	389	Shared Neighborhood Hits	197
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SH3K1_MOUSE
θ value	5.44631e-05 (rank : 63)	NC score	0.546067 (rank : 24)
Query Neighborhood Hits	314	Target Neighborhood Hits	332	Shared Neighborhood Hits	193
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

STAM1_HUMAN
θ value	5.44631e-05 (rank : 64)	NC score	0.518359 (rank : 34)
Query Neighborhood Hits	314	Target Neighborhood Hits	271	Shared Neighborhood Hits	202
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	5.44631e-05 (rank : 65)	NC score	0.521524 (rank : 33)
Query Neighborhood Hits	314	Target Neighborhood Hits	273	Shared Neighborhood Hits	199
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PACN2_MOUSE
θ value	7.1131e-05 (rank : 66)	NC score	0.472069 (rank : 41)
Query Neighborhood Hits	314	Target Neighborhood Hits	382	Shared Neighborhood Hits	186
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PPIP1_MOUSE
θ value	7.1131e-05 (rank : 67)	NC score	0.495431 (rank : 38)
Query Neighborhood Hits	314	Target Neighborhood Hits	377	Shared Neighborhood Hits	196
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

FRK_HUMAN
θ value	9.29e-05 (rank : 68)	NC score	0.261924 (rank : 190)
Query Neighborhood Hits	314	Target Neighborhood Hits	1058	Shared Neighborhood Hits	259
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

NCF4_MOUSE
θ value	9.29e-05 (rank : 69)	NC score	0.456993 (rank : 53)
Query Neighborhood Hits	314	Target Neighborhood Hits	177	Shared Neighborhood Hits	141
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM2_HUMAN
θ value	9.29e-05 (rank : 70)	NC score	0.503309 (rank : 36)
Query Neighborhood Hits	314	Target Neighborhood Hits	288	Shared Neighborhood Hits	191
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

FER_HUMAN
θ value	0.000121331 (rank : 71)	NC score	0.207660 (rank : 253)
Query Neighborhood Hits	314	Target Neighborhood Hits	1278	Shared Neighborhood Hits	149
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

P55G_MOUSE
θ value	0.000121331 (rank : 72)	NC score	0.390360 (rank : 113)
Query Neighborhood Hits	314	Target Neighborhood Hits	401	Shared Neighborhood Hits	124
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PLCG2_HUMAN
θ value	0.000121331 (rank : 73)	NC score	0.551055 (rank : 23)
Query Neighborhood Hits	314	Target Neighborhood Hits	280	Shared Neighborhood Hits	225
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SNX18_MOUSE
θ value	0.000121331 (rank : 74)	NC score	0.327305 (rank : 141)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

TXK_MOUSE
θ value	0.000121331 (rank : 75)	NC score	0.244231 (rank : 211)
Query Neighborhood Hits	314	Target Neighborhood Hits	980	Shared Neighborhood Hits	208
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

VAV2_MOUSE
θ value	0.000121331 (rank : 76)	NC score	0.532887 (rank : 27)
Query Neighborhood Hits	314	Target Neighborhood Hits	456	Shared Neighborhood Hits	248
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FGR_HUMAN
θ value	0.000158464 (rank : 77)	NC score	0.293360 (rank : 166)
Query Neighborhood Hits	314	Target Neighborhood Hits	1067	Shared Neighborhood Hits	264
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_HUMAN
θ value	0.000158464 (rank : 78)	NC score	0.285978 (rank : 175)
Query Neighborhood Hits	314	Target Neighborhood Hits	1078	Shared Neighborhood Hits	269
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.000158464 (rank : 79)	NC score	0.288900 (rank : 173)
Query Neighborhood Hits	314	Target Neighborhood Hits	1073	Shared Neighborhood Hits	263
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ITSN2_MOUSE
θ value	0.000158464 (rank : 80)	NC score	0.355410 (rank : 125)
Query Neighborhood Hits	314	Target Neighborhood Hits	1371	Shared Neighborhood Hits	221
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LYN_MOUSE
θ value	0.000158464 (rank : 81)	NC score	0.247430 (rank : 208)
Query Neighborhood Hits	314	Target Neighborhood Hits	1023	Shared Neighborhood Hits	213
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PACN2_HUMAN
θ value	0.000158464 (rank : 82)	NC score	0.470737 (rank : 42)
Query Neighborhood Hits	314	Target Neighborhood Hits	339	Shared Neighborhood Hits	180
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SRC_HUMAN
θ value	0.000158464 (rank : 83)	NC score	0.286363 (rank : 174)
Query Neighborhood Hits	314	Target Neighborhood Hits	1058	Shared Neighborhood Hits	266
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	0.000158464 (rank : 84)	NC score	0.269138 (rank : 184)
Query Neighborhood Hits	314	Target Neighborhood Hits	1033	Shared Neighborhood Hits	235
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

AHI1_HUMAN
θ value	0.00020696 (rank : 85)	NC score	0.369160 (rank : 119)
Query Neighborhood Hits	314	Target Neighborhood Hits	537	Shared Neighborhood Hits	189
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ITK_MOUSE
θ value	0.00020696 (rank : 86)	NC score	0.221601 (rank : 242)
Query Neighborhood Hits	314	Target Neighborhood Hits	985	Shared Neighborhood Hits	178
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITSN2_HUMAN
θ value	0.00020696 (rank : 87)	NC score	0.372285 (rank : 118)
Query Neighborhood Hits	314	Target Neighborhood Hits	1173	Shared Neighborhood Hits	225
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PACN1_HUMAN
θ value	0.00020696 (rank : 88)	NC score	0.468976 (rank : 45)
Query Neighborhood Hits	314	Target Neighborhood Hits	320	Shared Neighborhood Hits	179
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.00020696 (rank : 89)	NC score	0.467732 (rank : 46)
Query Neighborhood Hits	314	Target Neighborhood Hits	283	Shared Neighborhood Hits	177
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SHC2_MOUSE
θ value	0.00020696 (rank : 90)	NC score	0.444148 (rank : 65)
Query Neighborhood Hits	314	Target Neighborhood Hits	144	Shared Neighborhood Hits	122
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

DLG2_MOUSE
θ value	0.000270298 (rank : 91)	NC score	0.203988 (rank : 258)
Query Neighborhood Hits	314	Target Neighborhood Hits	271	Shared Neighborhood Hits	86
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

EPS8_HUMAN
θ value	0.000270298 (rank : 92)	NC score	0.315364 (rank : 149)
Query Neighborhood Hits	314	Target Neighborhood Hits	151	Shared Neighborhood Hits	111
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ITK_HUMAN
θ value	0.000270298 (rank : 93)	NC score	0.226920 (rank : 236)
Query Neighborhood Hits	314	Target Neighborhood Hits	1016	Shared Neighborhood Hits	192
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SPTA1_HUMAN
θ value	0.000270298 (rank : 94)	NC score	0.227008 (rank : 235)
Query Neighborhood Hits	314	Target Neighborhood Hits	748	Shared Neighborhood Hits	168
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TEC_MOUSE
θ value	0.000270298 (rank : 95)	NC score	0.229469 (rank : 233)
Query Neighborhood Hits	314	Target Neighborhood Hits	1006	Shared Neighborhood Hits	188
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ARHG7_HUMAN
θ value	0.00035302 (rank : 96)	NC score	0.454986 (rank : 55)
Query Neighborhood Hits	314	Target Neighborhood Hits	347	Shared Neighborhood Hits	200
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DLG2_HUMAN
θ value	0.00035302 (rank : 97)	NC score	0.201949 (rank : 260)
Query Neighborhood Hits	314	Target Neighborhood Hits	279	Shared Neighborhood Hits	86
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PTK6_MOUSE
θ value	0.00035302 (rank : 98)	NC score	0.242161 (rank : 213)
Query Neighborhood Hits	314	Target Neighborhood Hits	1026	Shared Neighborhood Hits	230
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TEC_HUMAN
θ value	0.00035302 (rank : 99)	NC score	0.233031 (rank : 230)
Query Neighborhood Hits	314	Target Neighborhood Hits	1006	Shared Neighborhood Hits	190
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

APS_HUMAN
θ value	0.000461057 (rank : 100)	NC score	0.434207 (rank : 75)
Query Neighborhood Hits	314	Target Neighborhood Hits	162	Shared Neighborhood Hits	107
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ES8L1_MOUSE
θ value	0.000461057 (rank : 101)	NC score	0.293299 (rank : 167)
Query Neighborhood Hits	314	Target Neighborhood Hits	143	Shared Neighborhood Hits	93
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FGR_MOUSE
θ value	0.000461057 (rank : 102)	NC score	0.296656 (rank : 165)
Query Neighborhood Hits	314	Target Neighborhood Hits	1069	Shared Neighborhood Hits	269
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

NCF2_HUMAN
θ value	0.000461057 (rank : 103)	NC score	0.541778 (rank : 25)
Query Neighborhood Hits	314	Target Neighborhood Hits	229	Shared Neighborhood Hits	170
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

OSTF1_HUMAN
θ value	0.000461057 (rank : 104)	NC score	0.422390 (rank : 88)
Query Neighborhood Hits	314	Target Neighborhood Hits	466	Shared Neighborhood Hits	202
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

P85A_HUMAN
θ value	0.000461057 (rank : 105)	NC score	0.403484 (rank : 100)
Query Neighborhood Hits	314	Target Neighborhood Hits	479	Shared Neighborhood Hits	171
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PTN6_MOUSE
θ value	0.000461057 (rank : 106)	NC score	0.248880 (rank : 207)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	132
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

SHC2_HUMAN
θ value	0.000461057 (rank : 107)	NC score	0.440238 (rank : 70)
Query Neighborhood Hits	314	Target Neighborhood Hits	170	Shared Neighborhood Hits	121
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SLY_MOUSE
θ value	0.000461057 (rank : 108)	NC score	0.258687 (rank : 198)
Query Neighborhood Hits	314	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX18_HUMAN
θ value	0.000461057 (rank : 109)	NC score	0.315921 (rank : 147)
Query Neighborhood Hits	314	Target Neighborhood Hits	207	Shared Neighborhood Hits	129
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

BTK_HUMAN
θ value	0.000602161 (rank : 110)	NC score	0.260256 (rank : 194)
Query Neighborhood Hits	314	Target Neighborhood Hits	1026	Shared Neighborhood Hits	225
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SH3G2_HUMAN
θ value	0.000602161 (rank : 111)	NC score	0.459007 (rank : 51)
Query Neighborhood Hits	314	Target Neighborhood Hits	324	Shared Neighborhood Hits	188
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SRMS_MOUSE
θ value	0.000602161 (rank : 112)	NC score	0.219324 (rank : 243)
Query Neighborhood Hits	314	Target Neighborhood Hits	964	Shared Neighborhood Hits	171
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

DAPP1_MOUSE
θ value	0.000786445 (rank : 113)	NC score	0.453915 (rank : 57)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	137
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DLG1_HUMAN
θ value	0.000786445 (rank : 114)	NC score	0.197914 (rank : 266)
Query Neighborhood Hits	314	Target Neighborhood Hits	290	Shared Neighborhood Hits	80
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

GRB10_HUMAN
θ value	0.000786445 (rank : 115)	NC score	0.366795 (rank : 121)
Query Neighborhood Hits	314	Target Neighborhood Hits	147	Shared Neighborhood Hits	112
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	0.000786445 (rank : 116)	NC score	0.366135 (rank : 122)
Query Neighborhood Hits	314	Target Neighborhood Hits	156	Shared Neighborhood Hits	111
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

HCK_HUMAN
θ value	0.000786445 (rank : 117)	NC score	0.261907 (rank : 191)
Query Neighborhood Hits	314	Target Neighborhood Hits	1035	Shared Neighborhood Hits	231
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

P55G_HUMAN
θ value	0.000786445 (rank : 118)	NC score	0.390462 (rank : 112)
Query Neighborhood Hits	314	Target Neighborhood Hits	451	Shared Neighborhood Hits	128
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_MOUSE
θ value	0.000786445 (rank : 119)	NC score	0.413972 (rank : 96)
Query Neighborhood Hits	314	Target Neighborhood Hits	435	Shared Neighborhood Hits	178
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	0.000786445 (rank : 120)	NC score	0.399397 (rank : 107)
Query Neighborhood Hits	314	Target Neighborhood Hits	543	Shared Neighborhood Hits	151
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	0.000786445 (rank : 121)	NC score	0.398548 (rank : 108)
Query Neighborhood Hits	314	Target Neighborhood Hits	519	Shared Neighborhood Hits	149
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SH3G3_MOUSE
θ value	0.000786445 (rank : 122)	NC score	0.469546 (rank : 44)
Query Neighborhood Hits	314	Target Neighborhood Hits	236	Shared Neighborhood Hits	188
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SHB_MOUSE
θ value	0.000786445 (rank : 123)	NC score	0.431326 (rank : 79)
Query Neighborhood Hits	314	Target Neighborhood Hits	137	Shared Neighborhood Hits	125
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

AHI1_MOUSE
θ value	0.00102713 (rank : 124)	NC score	0.364912 (rank : 123)
Query Neighborhood Hits	314	Target Neighborhood Hits	496	Shared Neighborhood Hits	189
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

EM55_HUMAN
θ value	0.00102713 (rank : 125)	NC score	0.266874 (rank : 186)
Query Neighborhood Hits	314	Target Neighborhood Hits	228	Shared Neighborhood Hits	106
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	0.00102713 (rank : 126)	NC score	0.262067 (rank : 189)
Query Neighborhood Hits	314	Target Neighborhood Hits	221	Shared Neighborhood Hits	102
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

PACN3_HUMAN
θ value	0.00102713 (rank : 127)	NC score	0.440681 (rank : 69)
Query Neighborhood Hits	314	Target Neighborhood Hits	385	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.00102713 (rank : 128)	NC score	0.443665 (rank : 67)
Query Neighborhood Hits	314	Target Neighborhood Hits	380	Shared Neighborhood Hits	170
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SH3G3_HUMAN
θ value	0.00102713 (rank : 129)	NC score	0.450504 (rank : 61)
Query Neighborhood Hits	314	Target Neighborhood Hits	222	Shared Neighborhood Hits	178
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SOCS7_MOUSE
θ value	0.00102713 (rank : 130)	NC score	0.344144 (rank : 130)
Query Neighborhood Hits	314	Target Neighborhood Hits	154	Shared Neighborhood Hits	93
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

VINEX_MOUSE
θ value	0.00102713 (rank : 131)	NC score	0.527649 (rank : 30)
Query Neighborhood Hits	314	Target Neighborhood Hits	286	Shared Neighborhood Hits	189
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DLG1_MOUSE
θ value	0.00134147 (rank : 132)	NC score	0.196008 (rank : 269)
Query Neighborhood Hits	314	Target Neighborhood Hits	285	Shared Neighborhood Hits	77
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

LYN_HUMAN
θ value	0.00134147 (rank : 133)	NC score	0.245703 (rank : 209)
Query Neighborhood Hits	314	Target Neighborhood Hits	1022	Shared Neighborhood Hits	212
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SH3G2_MOUSE
θ value	0.00134147 (rank : 134)	NC score	0.450736 (rank : 60)
Query Neighborhood Hits	314	Target Neighborhood Hits	319	Shared Neighborhood Hits	186
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SOCS5_HUMAN
θ value	0.00134147 (rank : 135)	NC score	0.235809 (rank : 227)
Query Neighborhood Hits	314	Target Neighborhood Hits	91	Shared Neighborhood Hits	72
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	0.00134147 (rank : 136)	NC score	0.235160 (rank : 229)
Query Neighborhood Hits	314	Target Neighborhood Hits	93	Shared Neighborhood Hits	72
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

VINEX_HUMAN
θ value	0.00134147 (rank : 137)	NC score	0.530464 (rank : 29)
Query Neighborhood Hits	314	Target Neighborhood Hits	270	Shared Neighborhood Hits	188
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

LNK_MOUSE
θ value	0.00175202 (rank : 138)	NC score	0.425769 (rank : 83)
Query Neighborhood Hits	314	Target Neighborhood Hits	132	Shared Neighborhood Hits	107
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

OSTF1_MOUSE
θ value	0.00175202 (rank : 139)	NC score	0.401681 (rank : 101)
Query Neighborhood Hits	314	Target Neighborhood Hits	467	Shared Neighborhood Hits	203
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PTN6_HUMAN
θ value	0.00175202 (rank : 140)	NC score	0.241953 (rank : 214)
Query Neighborhood Hits	314	Target Neighborhood Hits	234	Shared Neighborhood Hits	126
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SHB_HUMAN
θ value	0.00175202 (rank : 141)	NC score	0.424557 (rank : 86)
Query Neighborhood Hits	314	Target Neighborhood Hits	141	Shared Neighborhood Hits	124
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

BTK_MOUSE
θ value	0.00228821 (rank : 142)	NC score	0.256431 (rank : 203)
Query Neighborhood Hits	314	Target Neighborhood Hits	1017	Shared Neighborhood Hits	216
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CSKP_HUMAN
θ value	0.00228821 (rank : 143)	NC score	0.127410 (rank : 316)
Query Neighborhood Hits	314	Target Neighborhood Hits	1022	Shared Neighborhood Hits	144
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	0.00228821 (rank : 144)	NC score	0.126449 (rank : 317)
Query Neighborhood Hits	314	Target Neighborhood Hits	1027	Shared Neighborhood Hits	151
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

SLY_HUMAN
θ value	0.00228821 (rank : 145)	NC score	0.235830 (rank : 226)
Query Neighborhood Hits	314	Target Neighborhood Hits	81	Shared Neighborhood Hits	58
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

TENS1_HUMAN
θ value	0.00228821 (rank : 146)	NC score	0.155193 (rank : 301)
Query Neighborhood Hits	314	Target Neighborhood Hits	400	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

ES8L1_HUMAN
θ value	0.00298849 (rank : 147)	NC score	0.305508 (rank : 158)
Query Neighborhood Hits	314	Target Neighborhood Hits	162	Shared Neighborhood Hits	104
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	0.00298849 (rank : 148)	NC score	0.329989 (rank : 135)
Query Neighborhood Hits	314	Target Neighborhood Hits	193	Shared Neighborhood Hits	130
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SRGP2_HUMAN
θ value	0.00298849 (rank : 149)	NC score	0.282124 (rank : 177)
Query Neighborhood Hits	314	Target Neighborhood Hits	331	Shared Neighborhood Hits	152
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

TXK_HUMAN
θ value	0.00298849 (rank : 150)	NC score	0.232950 (rank : 231)
Query Neighborhood Hits	314	Target Neighborhood Hits	971	Shared Neighborhood Hits	189
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ARHG6_MOUSE
θ value	0.00390308 (rank : 151)	NC score	0.427507 (rank : 81)
Query Neighborhood Hits	314	Target Neighborhood Hits	394	Shared Neighborhood Hits	188
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

KSYK_MOUSE
θ value	0.00390308 (rank : 152)	NC score	0.194833 (rank : 273)
Query Neighborhood Hits	314	Target Neighborhood Hits	944	Shared Neighborhood Hits	126
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LNK_HUMAN
θ value	0.00390308 (rank : 153)	NC score	0.422120 (rank : 89)
Query Neighborhood Hits	314	Target Neighborhood Hits	151	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MPP6_HUMAN
θ value	0.00390308 (rank : 154)	NC score	0.272550 (rank : 182)
Query Neighborhood Hits	314	Target Neighborhood Hits	180	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	0.00390308 (rank : 155)	NC score	0.264982 (rank : 187)
Query Neighborhood Hits	314	Target Neighborhood Hits	187	Shared Neighborhood Hits	94
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

SRGP2_MOUSE
θ value	0.00390308 (rank : 156)	NC score	0.283228 (rank : 176)
Query Neighborhood Hits	314	Target Neighborhood Hits	324	Shared Neighborhood Hits	153
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

MPP5_HUMAN
θ value	0.00509761 (rank : 157)	NC score	0.239192 (rank : 220)
Query Neighborhood Hits	314	Target Neighborhood Hits	231	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.00509761 (rank : 158)	NC score	0.238652 (rank : 221)
Query Neighborhood Hits	314	Target Neighborhood Hits	226	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

SOCS2_HUMAN
θ value	0.00509761 (rank : 159)	NC score	0.328179 (rank : 140)
Query Neighborhood Hits	314	Target Neighborhood Hits	104	Shared Neighborhood Hits	84
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	0.00509761 (rank : 160)	NC score	0.335989 (rank : 133)
Query Neighborhood Hits	314	Target Neighborhood Hits	94	Shared Neighborhood Hits	84
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

APS_MOUSE
θ value	0.00665767 (rank : 161)	NC score	0.372841 (rank : 116)
Query Neighborhood Hits	314	Target Neighborhood Hits	134	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CASL_HUMAN
θ value	0.00665767 (rank : 162)	NC score	0.314914 (rank : 151)
Query Neighborhood Hits	314	Target Neighborhood Hits	259	Shared Neighborhood Hits	150
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0.00665767 (rank : 163)	NC score	0.316602 (rank : 146)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	150
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

DLG4_HUMAN
θ value	0.00665767 (rank : 164)	NC score	0.196100 (rank : 267)
Query Neighborhood Hits	314	Target Neighborhood Hits	286	Shared Neighborhood Hits	85
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

MYO1E_HUMAN
θ value	0.00665767 (rank : 165)	NC score	0.201678 (rank : 262)
Query Neighborhood Hits	314	Target Neighborhood Hits	293	Shared Neighborhood Hits	178
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NCF1_HUMAN
θ value	0.00665767 (rank : 166)	NC score	0.465369 (rank : 48)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	162
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SH3G1_HUMAN
θ value	0.00665767 (rank : 167)	NC score	0.434496 (rank : 74)
Query Neighborhood Hits	314	Target Neighborhood Hits	307	Shared Neighborhood Hits	179
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

CISH_HUMAN
θ value	0.00869519 (rank : 168)	NC score	0.303004 (rank : 161)
Query Neighborhood Hits	314	Target Neighborhood Hits	94	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CISH_MOUSE
θ value	0.00869519 (rank : 169)	NC score	0.299611 (rank : 164)
Query Neighborhood Hits	314	Target Neighborhood Hits	94	Shared Neighborhood Hits	85
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

DAPP1_HUMAN
θ value	0.00869519 (rank : 170)	NC score	0.450078 (rank : 62)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DLG3_HUMAN
θ value	0.00869519 (rank : 171)	NC score	0.194011 (rank : 274)
Query Neighborhood Hits	314	Target Neighborhood Hits	269	Shared Neighborhood Hits	85
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	0.00869519 (rank : 172)	NC score	0.193218 (rank : 275)
Query Neighborhood Hits	314	Target Neighborhood Hits	274	Shared Neighborhood Hits	85
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

SHD_MOUSE
θ value	0.00869519 (rank : 173)	NC score	0.426934 (rank : 82)
Query Neighborhood Hits	314	Target Neighborhood Hits	137	Shared Neighborhood Hits	122
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SRMS_HUMAN
θ value	0.00869519 (rank : 174)	NC score	0.212316 (rank : 249)
Query Neighborhood Hits	314	Target Neighborhood Hits	946	Shared Neighborhood Hits	147
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

EPS8_MOUSE
θ value	0.0113563 (rank : 175)	NC score	0.307746 (rank : 157)
Query Neighborhood Hits	314	Target Neighborhood Hits	157	Shared Neighborhood Hits	125
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

HCK_MOUSE
θ value	0.0113563 (rank : 176)	NC score	0.259739 (rank : 195)
Query Neighborhood Hits	314	Target Neighborhood Hits	1029	Shared Neighborhood Hits	225
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

MPP4_HUMAN
θ value	0.0113563 (rank : 177)	NC score	0.230195 (rank : 232)
Query Neighborhood Hits	314	Target Neighborhood Hits	205	Shared Neighborhood Hits	70
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

NCF1_MOUSE
θ value	0.0113563 (rank : 178)	NC score	0.452108 (rank : 59)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	166
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SAMN1_HUMAN
θ value	0.0113563 (rank : 179)	NC score	0.196074 (rank : 268)
Query Neighborhood Hits	314	Target Neighborhood Hits	74	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

DDEF2_HUMAN
θ value	0.0148317 (rank : 180)	NC score	0.199097 (rank : 264)
Query Neighborhood Hits	314	Target Neighborhood Hits	599	Shared Neighborhood Hits	146
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DLG4_MOUSE
θ value	0.0148317 (rank : 181)	NC score	0.189721 (rank : 279)
Query Neighborhood Hits	314	Target Neighborhood Hits	282	Shared Neighborhood Hits	81
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

LCK_HUMAN
θ value	0.0148317 (rank : 182)	NC score	0.237908 (rank : 222)
Query Neighborhood Hits	314	Target Neighborhood Hits	987	Shared Neighborhood Hits	181
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	0.0148317 (rank : 183)	NC score	0.235566 (rank : 228)
Query Neighborhood Hits	314	Target Neighborhood Hits	981	Shared Neighborhood Hits	182
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MPP4_MOUSE
θ value	0.0148317 (rank : 184)	NC score	0.240472 (rank : 217)
Query Neighborhood Hits	314	Target Neighborhood Hits	188	Shared Neighborhood Hits	75
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

SH3G1_MOUSE
θ value	0.0148317 (rank : 185)	NC score	0.437298 (rank : 72)
Query Neighborhood Hits	314	Target Neighborhood Hits	291	Shared Neighborhood Hits	185
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SHD_HUMAN
θ value	0.0148317 (rank : 186)	NC score	0.406423 (rank : 99)
Query Neighborhood Hits	314	Target Neighborhood Hits	204	Shared Neighborhood Hits	120
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SOCS4_HUMAN
θ value	0.0148317 (rank : 187)	NC score	0.205916 (rank : 255)
Query Neighborhood Hits	314	Target Neighborhood Hits	69	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_MOUSE
θ value	0.0148317 (rank : 188)	NC score	0.208167 (rank : 252)
Query Neighborhood Hits	314	Target Neighborhood Hits	69	Shared Neighborhood Hits	50
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SRGP1_HUMAN
θ value	0.0148317 (rank : 189)	NC score	0.268519 (rank : 185)
Query Neighborhood Hits	314	Target Neighborhood Hits	390	Shared Neighborhood Hits	147
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAC3_HUMAN
θ value	0.0148317 (rank : 190)	NC score	0.416897 (rank : 94)
Query Neighborhood Hits	314	Target Neighborhood Hits	228	Shared Neighborhood Hits	153
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.0148317 (rank : 191)	NC score	0.418520 (rank : 91)
Query Neighborhood Hits	314	Target Neighborhood Hits	232	Shared Neighborhood Hits	154
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG4_HUMAN
θ value	0.0193708 (rank : 192)	NC score	0.326533 (rank : 143)
Query Neighborhood Hits	314	Target Neighborhood Hits	242	Shared Neighborhood Hits	165
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	0.0193708 (rank : 193)	NC score	0.422678 (rank : 87)
Query Neighborhood Hits	314	Target Neighborhood Hits	376	Shared Neighborhood Hits	184
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

DBNL_HUMAN
θ value	0.0193708 (rank : 194)	NC score	0.400975 (rank : 102)
Query Neighborhood Hits	314	Target Neighborhood Hits	244	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.0193708 (rank : 195)	NC score	0.397290 (rank : 109)
Query Neighborhood Hits	314	Target Neighborhood Hits	306	Shared Neighborhood Hits	150
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SASH1_MOUSE
θ value	0.0193708 (rank : 196)	NC score	0.178001 (rank : 288)
Query Neighborhood Hits	314	Target Neighborhood Hits	263	Shared Neighborhood Hits	60
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

MYO1F_MOUSE
θ value	0.0252991 (rank : 197)	NC score	0.204302 (rank : 257)
Query Neighborhood Hits	314	Target Neighborhood Hits	262	Shared Neighborhood Hits	187
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SASH1_HUMAN
θ value	0.0252991 (rank : 198)	NC score	0.183435 (rank : 283)
Query Neighborhood Hits	314	Target Neighborhood Hits	292	Shared Neighborhood Hits	64
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SHE_MOUSE
θ value	0.0252991 (rank : 199)	NC score	0.438030 (rank : 71)
Query Neighborhood Hits	314	Target Neighborhood Hits	169	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SOCS3_HUMAN
θ value	0.0252991 (rank : 200)	NC score	0.252905 (rank : 205)
Query Neighborhood Hits	314	Target Neighborhood Hits	77	Shared Neighborhood Hits	67
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	0.0252991 (rank : 201)	NC score	0.243583 (rank : 212)
Query Neighborhood Hits	314	Target Neighborhood Hits	72	Shared Neighborhood Hits	68
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS6_HUMAN
θ value	0.0252991 (rank : 202)	NC score	0.326691 (rank : 142)
Query Neighborhood Hits	314	Target Neighborhood Hits	126	Shared Neighborhood Hits	95
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	0.0252991 (rank : 203)	NC score	0.329864 (rank : 136)
Query Neighborhood Hits	314	Target Neighborhood Hits	146	Shared Neighborhood Hits	97
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

DLG5_HUMAN
θ value	0.0330416 (rank : 204)	NC score	0.102748 (rank : 443)
Query Neighborhood Hits	314	Target Neighborhood Hits	1088	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ES8L3_MOUSE
θ value	0.0330416 (rank : 205)	NC score	0.354841 (rank : 127)
Query Neighborhood Hits	314	Target Neighborhood Hits	168	Shared Neighborhood Hits	139
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

MYO1F_HUMAN
θ value	0.0330416 (rank : 206)	NC score	0.205564 (rank : 256)
Query Neighborhood Hits	314	Target Neighborhood Hits	275	Shared Neighborhood Hits	184
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NCF4_HUMAN
θ value	0.0330416 (rank : 207)	NC score	0.421023 (rank : 90)
Query Neighborhood Hits	314	Target Neighborhood Hits	161	Shared Neighborhood Hits	128
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	0.0330416 (rank : 208)	NC score	0.346314 (rank : 129)
Query Neighborhood Hits	314	Target Neighborhood Hits	457	Shared Neighborhood Hits	155
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

DDEF1_MOUSE
θ value	0.0431538 (rank : 209)	NC score	0.218581 (rank : 244)
Query Neighborhood Hits	314	Target Neighborhood Hits	592	Shared Neighborhood Hits	146
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FNBP2_HUMAN
θ value	0.0431538 (rank : 210)	NC score	0.264000 (rank : 188)
Query Neighborhood Hits	314	Target Neighborhood Hits	432	Shared Neighborhood Hits	148
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

HSH2D_HUMAN
θ value	0.0431538 (rank : 211)	NC score	0.395388 (rank : 111)
Query Neighborhood Hits	314	Target Neighborhood Hits	159	Shared Neighborhood Hits	121
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

LASP1_HUMAN
θ value	0.0431538 (rank : 212)	NC score	0.368448 (rank : 120)
Query Neighborhood Hits	314	Target Neighborhood Hits	293	Shared Neighborhood Hits	151
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

M3K10_HUMAN
θ value	0.0431538 (rank : 213)	NC score	0.171785 (rank : 294)
Query Neighborhood Hits	314	Target Neighborhood Hits	1071	Shared Neighborhood Hits	166
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MPP3_HUMAN
θ value	0.0431538 (rank : 214)	NC score	0.203279 (rank : 259)
Query Neighborhood Hits	314	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

RIMB1_MOUSE
θ value	0.0431538 (rank : 215)	NC score	0.169392 (rank : 295)
Query Neighborhood Hits	314	Target Neighborhood Hits	1376	Shared Neighborhood Hits	159
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

BCAR1_MOUSE
θ value	0.0563607 (rank : 216)	NC score	0.329808 (rank : 137)
Query Neighborhood Hits	314	Target Neighborhood Hits	438	Shared Neighborhood Hits	173
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DDEF2_MOUSE
θ value	0.0563607 (rank : 217)	NC score	0.195490 (rank : 272)
Query Neighborhood Hits	314	Target Neighborhood Hits	625	Shared Neighborhood Hits	148
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

KSYK_HUMAN
θ value	0.0563607 (rank : 218)	NC score	0.191140 (rank : 278)
Query Neighborhood Hits	314	Target Neighborhood Hits	901	Shared Neighborhood Hits	124
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LASP1_MOUSE
θ value	0.0563607 (rank : 219)	NC score	0.364326 (rank : 124)
Query Neighborhood Hits	314	Target Neighborhood Hits	297	Shared Neighborhood Hits	150
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NOXO1_HUMAN
θ value	0.0563607 (rank : 220)	NC score	0.256506 (rank : 202)
Query Neighborhood Hits	314	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SLAP2_HUMAN
θ value	0.0563607 (rank : 221)	NC score	0.453387 (rank : 58)
Query Neighborhood Hits	314	Target Neighborhood Hits	139	Shared Neighborhood Hits	130
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

CSKI2_MOUSE
θ value	0.0736092 (rank : 222)	NC score	0.049362 (rank : 896)
Query Neighborhood Hits	314	Target Neighborhood Hits	812	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

SAMN1_MOUSE
θ value	0.0736092 (rank : 223)	NC score	0.184662 (rank : 282)
Query Neighborhood Hits	314	Target Neighborhood Hits	69	Shared Neighborhood Hits	45
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SHE_HUMAN
θ value	0.0736092 (rank : 224)	NC score	0.425375 (rank : 85)
Query Neighborhood Hits	314	Target Neighborhood Hits	164	Shared Neighborhood Hits	124
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

TENS4_HUMAN
θ value	0.0736092 (rank : 225)	NC score	0.195605 (rank : 271)
Query Neighborhood Hits	314	Target Neighborhood Hits	214	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

ASPP2_HUMAN
θ value	0.0961366 (rank : 226)	NC score	0.184977 (rank : 281)
Query Neighborhood Hits	314	Target Neighborhood Hits	1156	Shared Neighborhood Hits	152
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ES8L2_MOUSE
θ value	0.0961366 (rank : 227)	NC score	0.319498 (rank : 144)
Query Neighborhood Hits	314	Target Neighborhood Hits	169	Shared Neighborhood Hits	126
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

HCLS1_MOUSE
θ value	0.0961366 (rank : 228)	NC score	0.446723 (rank : 63)
Query Neighborhood Hits	314	Target Neighborhood Hits	329	Shared Neighborhood Hits	164
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

RUSC1_HUMAN
θ value	0.0961366 (rank : 229)	NC score	0.290036 (rank : 170)
Query Neighborhood Hits	314	Target Neighborhood Hits	226	Shared Neighborhood Hits	132
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SH22A_HUMAN
θ value	0.0961366 (rank : 230)	NC score	0.311199 (rank : 155)
Query Neighborhood Hits	314	Target Neighborhood Hits	144	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

STAC_HUMAN
θ value	0.0961366 (rank : 231)	NC score	0.465294 (rank : 49)
Query Neighborhood Hits	314	Target Neighborhood Hits	276	Shared Neighborhood Hits	187
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BLK_MOUSE
θ value	0.125558 (rank : 232)	NC score	0.240951 (rank : 216)
Query Neighborhood Hits	314	Target Neighborhood Hits	992	Shared Neighborhood Hits	193
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

M3KL4_HUMAN
θ value	0.125558 (rank : 233)	NC score	0.193018 (rank : 276)
Query Neighborhood Hits	314	Target Neighborhood Hits	1087	Shared Neighborhood Hits	179
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MPP3_MOUSE
θ value	0.125558 (rank : 234)	NC score	0.198574 (rank : 265)
Query Neighborhood Hits	314	Target Neighborhood Hits	165	Shared Neighborhood Hits	47
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

NEBU_HUMAN
θ value	0.125558 (rank : 235)	NC score	0.302408 (rank : 162)
Query Neighborhood Hits	314	Target Neighborhood Hits	420	Shared Neighborhood Hits	157
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

TENS4_MOUSE
θ value	0.125558 (rank : 236)	NC score	0.200922 (rank : 263)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

ARHG4_MOUSE
θ value	0.163984 (rank : 237)	NC score	0.259558 (rank : 196)
Query Neighborhood Hits	314	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ASPP1_MOUSE
θ value	0.163984 (rank : 238)	NC score	0.211185 (rank : 250)
Query Neighborhood Hits	314	Target Neighborhood Hits	1244	Shared Neighborhood Hits	165
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

EFS_HUMAN
θ value	0.163984 (rank : 239)	NC score	0.313493 (rank : 153)
Query Neighborhood Hits	314	Target Neighborhood Hits	348	Shared Neighborhood Hits	152
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

RIMB1_HUMAN
θ value	0.163984 (rank : 240)	NC score	0.175305 (rank : 292)
Query Neighborhood Hits	314	Target Neighborhood Hits	1479	Shared Neighborhood Hits	155
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUSC1_MOUSE
θ value	0.163984 (rank : 241)	NC score	0.256315 (rank : 204)
Query Neighborhood Hits	314	Target Neighborhood Hits	206	Shared Neighborhood Hits	124
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SLAP2_MOUSE
θ value	0.163984 (rank : 242)	NC score	0.444926 (rank : 64)
Query Neighborhood Hits	314	Target Neighborhood Hits	136	Shared Neighborhood Hits	123
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ABI2_HUMAN
θ value	0.21417 (rank : 243)	NC score	0.432372 (rank : 77)
Query Neighborhood Hits	314	Target Neighborhood Hits	350	Shared Neighborhood Hits	185
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.21417 (rank : 244)	NC score	0.435147 (rank : 73)
Query Neighborhood Hits	314	Target Neighborhood Hits	266	Shared Neighborhood Hits	183
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ASPP1_HUMAN
θ value	0.21417 (rank : 245)	NC score	0.216968 (rank : 245)
Query Neighborhood Hits	314	Target Neighborhood Hits	956	Shared Neighborhood Hits	159
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BSPRY_MOUSE
θ value	0.21417 (rank : 246)	NC score	0.013537 (rank : 901)
Query Neighborhood Hits	314	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

CT032_HUMAN
θ value	0.21417 (rank : 247)	NC score	0.339348 (rank : 132)
Query Neighborhood Hits	314	Target Neighborhood Hits	235	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

HCLS1_HUMAN
θ value	0.21417 (rank : 248)	NC score	0.442759 (rank : 68)
Query Neighborhood Hits	314	Target Neighborhood Hits	358	Shared Neighborhood Hits	165
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HSH2D_MOUSE
θ value	0.21417 (rank : 249)	NC score	0.317678 (rank : 145)
Query Neighborhood Hits	314	Target Neighborhood Hits	124	Shared Neighborhood Hits	102
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

NOXO1_MOUSE
θ value	0.21417 (rank : 250)	NC score	0.308587 (rank : 156)
Query Neighborhood Hits	314	Target Neighborhood Hits	114	Shared Neighborhood Hits	98
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

RIMB2_MOUSE
θ value	0.21417 (rank : 251)	NC score	0.269316 (rank : 183)
Query Neighborhood Hits	314	Target Neighborhood Hits	246	Shared Neighborhood Hits	112
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SART3_MOUSE
θ value	0.21417 (rank : 252)	NC score	0.017194 (rank : 900)
Query Neighborhood Hits	314	Target Neighborhood Hits	341	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLI8, Q6ZQI2, Q8BPK9, Q8C3B7, Q8CFU9	Gene names	Sart3, Kiaa0156
Domain Architecture	No domain graphic available
Description	Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (mSART-3) (Tumor-rejection antigen SART3).

STAC_MOUSE
θ value	0.21417 (rank : 253)	NC score	0.456413 (rank : 54)
Query Neighborhood Hits	314	Target Neighborhood Hits	268	Shared Neighborhood Hits	184
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BCAR1_HUMAN
θ value	0.279714 (rank : 254)	NC score	0.315262 (rank : 150)
Query Neighborhood Hits	314	Target Neighborhood Hits	554	Shared Neighborhood Hits	175
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

M3K9_HUMAN
θ value	0.279714 (rank : 255)	NC score	0.176060 (rank : 291)
Query Neighborhood Hits	314	Target Neighborhood Hits	1123	Shared Neighborhood Hits	179
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

RIMB2_HUMAN
θ value	0.279714 (rank : 256)	NC score	0.272846 (rank : 181)
Query Neighborhood Hits	314	Target Neighborhood Hits	263	Shared Neighborhood Hits	120
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ZAP70_HUMAN
θ value	0.279714 (rank : 257)	NC score	0.179604 (rank : 287)
Query Neighborhood Hits	314	Target Neighborhood Hits	893	Shared Neighborhood Hits	122
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	0.279714 (rank : 258)	NC score	0.180925 (rank : 286)
Query Neighborhood Hits	314	Target Neighborhood Hits	905	Shared Neighborhood Hits	123
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

BLK_HUMAN
θ value	0.365318 (rank : 259)	NC score	0.237194 (rank : 223)
Query Neighborhood Hits	314	Target Neighborhood Hits	994	Shared Neighborhood Hits	196
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MPP2_HUMAN
θ value	0.365318 (rank : 260)	NC score	0.229058 (rank : 234)
Query Neighborhood Hits	314	Target Neighborhood Hits	173	Shared Neighborhood Hits	87
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	0.365318 (rank : 261)	NC score	0.226777 (rank : 237)
Query Neighborhood Hits	314	Target Neighborhood Hits	189	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

PEX13_HUMAN
θ value	0.365318 (rank : 262)	NC score	0.314190 (rank : 152)
Query Neighborhood Hits	314	Target Neighborhood Hits	128	Shared Neighborhood Hits	109
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SHAN1_HUMAN
θ value	0.365318 (rank : 263)	NC score	0.149720 (rank : 305)
Query Neighborhood Hits	314	Target Neighborhood Hits	1041	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EFS_MOUSE
θ value	0.47712 (rank : 264)	NC score	0.328615 (rank : 139)
Query Neighborhood Hits	314	Target Neighborhood Hits	389	Shared Neighborhood Hits	162
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SH21B_MOUSE
θ value	0.47712 (rank : 265)	NC score	0.380492 (rank : 114)
Query Neighborhood Hits	314	Target Neighborhood Hits	101	Shared Neighborhood Hits	92
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_MOUSE
θ value	0.47712 (rank : 266)	NC score	0.311675 (rank : 154)
Query Neighborhood Hits	314	Target Neighborhood Hits	179	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

JIP1_HUMAN
θ value	0.62314 (rank : 267)	NC score	0.093737 (rank : 480)
Query Neighborhood Hits	314	Target Neighborhood Hits	271	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SRC8_HUMAN
θ value	0.62314 (rank : 268)	NC score	0.431505 (rank : 78)
Query Neighborhood Hits	314	Target Neighborhood Hits	269	Shared Neighborhood Hits	171
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	0.62314 (rank : 269)	NC score	0.425614 (rank : 84)
Query Neighborhood Hits	314	Target Neighborhood Hits	292	Shared Neighborhood Hits	172
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

JIP1_MOUSE
θ value	0.813845 (rank : 270)	NC score	0.090249 (rank : 493)
Query Neighborhood Hits	314	Target Neighborhood Hits	259	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NOTC2_HUMAN
θ value	0.813845 (rank : 271)	NC score	0.000794 (rank : 909)
Query Neighborhood Hits	314	Target Neighborhood Hits	1113	Shared Neighborhood Hits	22
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

SLAP1_HUMAN
θ value	0.813845 (rank : 272)	NC score	0.399515 (rank : 106)
Query Neighborhood Hits	314	Target Neighborhood Hits	113	Shared Neighborhood Hits	107
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	0.813845 (rank : 273)	NC score	0.400518 (rank : 103)
Query Neighborhood Hits	314	Target Neighborhood Hits	117	Shared Neighborhood Hits	107
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

ANM2_HUMAN
θ value	1.06291 (rank : 274)	NC score	0.257948 (rank : 199)
Query Neighborhood Hits	314	Target Neighborhood Hits	175	Shared Neighborhood Hits	148
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	1.06291 (rank : 275)	NC score	0.244644 (rank : 210)
Query Neighborhood Hits	314	Target Neighborhood Hits	175	Shared Neighborhood Hits	144
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

M3K11_HUMAN
θ value	1.06291 (rank : 276)	NC score	0.181329 (rank : 285)
Query Neighborhood Hits	314	Target Neighborhood Hits	1136	Shared Neighborhood Hits	182
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PEX13_MOUSE
θ value	1.06291 (rank : 277)	NC score	0.304270 (rank : 160)
Query Neighborhood Hits	314	Target Neighborhood Hits	126	Shared Neighborhood Hits	112
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ABI1_MOUSE
θ value	1.38821 (rank : 278)	NC score	0.396319 (rank : 110)
Query Neighborhood Hits	314	Target Neighborhood Hits	246	Shared Neighborhood Hits	171
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

LCP2_HUMAN
θ value	1.38821 (rank : 279)	NC score	0.195672 (rank : 270)
Query Neighborhood Hits	314	Target Neighborhood Hits	531	Shared Neighborhood Hits	90
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SHAN2_MOUSE
θ value	1.38821 (rank : 280)	NC score	0.181375 (rank : 284)
Query Neighborhood Hits	314	Target Neighborhood Hits	446	Shared Neighborhood Hits	118
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPN90_HUMAN
θ value	1.38821 (rank : 281)	NC score	0.281385 (rank : 178)
Query Neighborhood Hits	314	Target Neighborhood Hits	157	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

CHIN_MOUSE
θ value	1.81305 (rank : 282)	NC score	0.187458 (rank : 280)
Query Neighborhood Hits	314	Target Neighborhood Hits	229	Shared Neighborhood Hits	113
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SH21B_HUMAN
θ value	1.81305 (rank : 283)	NC score	0.373478 (rank : 115)
Query Neighborhood Hits	314	Target Neighborhood Hits	101	Shared Neighborhood Hits	94
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

BMX_MOUSE
θ value	2.36792 (rank : 284)	NC score	0.177603 (rank : 289)
Query Neighborhood Hits	314	Target Neighborhood Hits	912	Shared Neighborhood Hits	112
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

LCP2_MOUSE
θ value	2.36792 (rank : 285)	NC score	0.223977 (rank : 241)
Query Neighborhood Hits	314	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SPN90_MOUSE
θ value	2.36792 (rank : 286)	NC score	0.251032 (rank : 206)
Query Neighborhood Hits	314	Target Neighborhood Hits	157	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ARHG9_HUMAN
θ value	3.0926 (rank : 287)	NC score	0.291297 (rank : 168)
Query Neighborhood Hits	314	Target Neighborhood Hits	235	Shared Neighborhood Hits	158
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	3.0926 (rank : 288)	NC score	0.289659 (rank : 171)
Query Neighborhood Hits	314	Target Neighborhood Hits	234	Shared Neighborhood Hits	158
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARI1A_HUMAN
θ value	3.0926 (rank : 289)	NC score	0.012961 (rank : 902)
Query Neighborhood Hits	314	Target Neighborhood Hits	787	Shared Neighborhood Hits	29
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

BMX_HUMAN
θ value	3.0926 (rank : 290)	NC score	0.177400 (rank : 290)
Query Neighborhood Hits	314	Target Neighborhood Hits	942	Shared Neighborhood Hits	115
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

FES_MOUSE
θ value	3.0926 (rank : 291)	NC score	0.147949 (rank : 307)
Query Neighborhood Hits	314	Target Neighborhood Hits	980	Shared Neighborhood Hits	93
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SNX9_MOUSE
θ value	3.0926 (rank : 292)	NC score	0.201687 (rank : 261)
Query Neighborhood Hits	314	Target Neighborhood Hits	141	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

ABI1_HUMAN
θ value	5.27518 (rank : 293)	NC score	0.372801 (rank : 117)
Query Neighborhood Hits	314	Target Neighborhood Hits	257	Shared Neighborhood Hits	170
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

BAIP2_HUMAN
θ value	5.27518 (rank : 294)	NC score	0.086522 (rank : 517)
Query Neighborhood Hits	314	Target Neighborhood Hits	192	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	5.27518 (rank : 295)	NC score	0.088661 (rank : 504)
Query Neighborhood Hits	314	Target Neighborhood Hits	185	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAT3_HUMAN
θ value	5.27518 (rank : 296)	NC score	0.007678 (rank : 908)
Query Neighborhood Hits	314	Target Neighborhood Hits	490	Shared Neighborhood Hits	12
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

CHIO_HUMAN
θ value	5.27518 (rank : 297)	NC score	0.164358 (rank : 296)
Query Neighborhood Hits	314	Target Neighborhood Hits	220	Shared Neighborhood Hits	101
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

FGD1_HUMAN
θ value	5.27518 (rank : 298)	NC score	0.063500 (rank : 606)
Query Neighborhood Hits	314	Target Neighborhood Hits	367	Shared Neighborhood Hits	32
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RIN2_MOUSE
θ value	5.27518 (rank : 299)	NC score	0.038447 (rank : 897)
Query Neighborhood Hits	314	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D684, Q99K06	Gene names	Rin2
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2).

S3TC1_HUMAN
θ value	5.27518 (rank : 300)	NC score	0.050333 (rank : 883)
Query Neighborhood Hits	314	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

SH24A_MOUSE
θ value	5.27518 (rank : 301)	NC score	0.236695 (rank : 224)
Query Neighborhood Hits	314	Target Neighborhood Hits	326	Shared Neighborhood Hits	91
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

TAF6_HUMAN
θ value	5.27518 (rank : 302)	NC score	0.008973 (rank : 905)
Query Neighborhood Hits	314	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

CSKI1_HUMAN
θ value	6.88961 (rank : 303)	NC score	0.034192 (rank : 899)
Query Neighborhood Hits	314	Target Neighborhood Hits	997	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	6.88961 (rank : 304)	NC score	0.035112 (rank : 898)
Query Neighborhood Hits	314	Target Neighborhood Hits	1031	Shared Neighborhood Hits	67
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NCOR2_MOUSE
θ value	6.88961 (rank : 305)	NC score	0.008911 (rank : 906)
Query Neighborhood Hits	314	Target Neighborhood Hits	790	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

SNX9_HUMAN
θ value	6.88961 (rank : 306)	NC score	0.209420 (rank : 251)
Query Neighborhood Hits	314	Target Neighborhood Hits	148	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

TIF1G_HUMAN
θ value	6.88961 (rank : 307)	NC score	0.000404 (rank : 910)
Query Neighborhood Hits	314	Target Neighborhood Hits	410	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

ABI3_HUMAN
θ value	8.99809 (rank : 308)	NC score	0.341671 (rank : 131)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	136
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG5_HUMAN
θ value	8.99809 (rank : 309)	NC score	0.145058 (rank : 309)
Query Neighborhood Hits	314	Target Neighborhood Hits	172	Shared Neighborhood Hits	87
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ATN1_HUMAN
θ value	8.99809 (rank : 310)	NC score	0.008466 (rank : 907)
Query Neighborhood Hits	314	Target Neighborhood Hits	676	Shared Neighborhood Hits	23
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

SOCS1_HUMAN
θ value	8.99809 (rank : 311)	NC score	0.214309 (rank : 247)
Query Neighborhood Hits	314	Target Neighborhood Hits	79	Shared Neighborhood Hits	65
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	8.99809 (rank : 312)	NC score	0.216898 (rank : 246)
Query Neighborhood Hits	314	Target Neighborhood Hits	82	Shared Neighborhood Hits	67
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SPAG8_HUMAN
θ value	8.99809 (rank : 313)	NC score	0.012405 (rank : 903)
Query Neighborhood Hits	314	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	Q99932, Q12937, Q5TCV8, Q8WWB4	Gene names	SPAG8
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 8 (Sperm membrane protein 1) (SMP-1) (HSD-1) (Sperm membrane protein BS-84).

TRI66_MOUSE
θ value	8.99809 (rank : 314)	NC score	0.009241 (rank : 904)
Query Neighborhood Hits	314	Target Neighborhood Hits	491	Shared Neighborhood Hits	12
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

AAPK1_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.055992 (rank : 734)
Query Neighborhood Hits	314	Target Neighborhood Hits	842	Shared Neighborhood Hits	50
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.055759 (rank : 738)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	50
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.055699 (rank : 739)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	50
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.112481 (rank : 370)
Query Neighborhood Hits	314	Target Neighborhood Hits	1243	Shared Neighborhood Hits	61
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.115478 (rank : 345)
Query Neighborhood Hits	314	Target Neighborhood Hits	942	Shared Neighborhood Hits	52
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

AB1IP_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.080184 (rank : 545)
Query Neighborhood Hits	314	Target Neighborhood Hits	213	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AB1IP_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.080739 (rank : 542)
Query Neighborhood Hits	314	Target Neighborhood Hits	181	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ABI3_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.335776 (rank : 134)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	137
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABR_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.074140 (rank : 568)
Query Neighborhood Hits	314	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACK1_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.131099 (rank : 315)
Query Neighborhood Hits	314	Target Neighborhood Hits	1140	Shared Neighborhood Hits	87
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.132403 (rank : 314)
Query Neighborhood Hits	314	Target Neighborhood Hits	1080	Shared Neighborhood Hits	92
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.078445 (rank : 554)
Query Neighborhood Hits	314	Target Neighborhood Hits	753	Shared Neighborhood Hits	50
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.078516 (rank : 553)
Query Neighborhood Hits	314	Target Neighborhood Hits	753	Shared Neighborhood Hits	50
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.081761 (rank : 535)
Query Neighborhood Hits	314	Target Neighborhood Hits	709	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.081292 (rank : 540)
Query Neighborhood Hits	314	Target Neighborhood Hits	715	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.083095 (rank : 528)
Query Neighborhood Hits	314	Target Neighborhood Hits	716	Shared Neighborhood Hits	50
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.082388 (rank : 530)
Query Neighborhood Hits	314	Target Neighborhood Hits	739	Shared Neighborhood Hits	50
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.075814 (rank : 560)
Query Neighborhood Hits	314	Target Neighborhood Hits	760	Shared Neighborhood Hits	50
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.076275 (rank : 559)
Query Neighborhood Hits	314	Target Neighborhood Hits	768	Shared Neighborhood Hits	50
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AL2S2_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.059169 (rank : 658)
Query Neighborhood Hits	314	Target Neighborhood Hits	727	Shared Neighborhood Hits	48
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.061834 (rank : 623)
Query Neighborhood Hits	314	Target Neighborhood Hits	709	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.059794 (rank : 639)
Query Neighborhood Hits	314	Target Neighborhood Hits	831	Shared Neighborhood Hits	51
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ALK_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.122459 (rank : 327)
Query Neighborhood Hits	314	Target Neighborhood Hits	795	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.123075 (rank : 326)
Query Neighborhood Hits	314	Target Neighborhood Hits	811	Shared Neighborhood Hits	53
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.076708 (rank : 557)
Query Neighborhood Hits	314	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

AMPH_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.096304 (rank : 470)
Query Neighborhood Hits	314	Target Neighborhood Hits	455	Shared Neighborhood Hits	79
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.086624 (rank : 514)
Query Neighborhood Hits	314	Target Neighborhood Hits	291	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANKK1_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.075695 (rank : 561)
Query Neighborhood Hits	314	Target Neighborhood Hits	1075	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.076395 (rank : 558)
Query Neighborhood Hits	314	Target Neighborhood Hits	1072	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.099066 (rank : 457)
Query Neighborhood Hits	314	Target Neighborhood Hits	612	Shared Neighborhood Hits	48
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.099077 (rank : 456)
Query Neighborhood Hits	314	Target Neighborhood Hits	600	Shared Neighborhood Hits	48
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.093817 (rank : 479)
Query Neighborhood Hits	314	Target Neighborhood Hits	646	Shared Neighborhood Hits	52
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.094532 (rank : 477)
Query Neighborhood Hits	314	Target Neighborhood Hits	607	Shared Neighborhood Hits	52
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

APBA1_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.061676 (rank : 625)
Query Neighborhood Hits	314	Target Neighborhood Hits	325	Shared Neighborhood Hits	34
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.058155 (rank : 681)
Query Neighborhood Hits	314	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.058851 (rank : 663)
Query Neighborhood Hits	314	Target Neighborhood Hits	219	Shared Neighborhood Hits	34
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.050688 (rank : 869)
Query Neighborhood Hits	314	Target Neighborhood Hits	201	Shared Neighborhood Hits	35
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

ARAF_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.096663 (rank : 468)
Query Neighborhood Hits	314	Target Neighborhood Hits	924	Shared Neighborhood Hits	63
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.096884 (rank : 465)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	60
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.082147 (rank : 532)
Query Neighborhood Hits	314	Target Neighborhood Hits	176	Shared Neighborhood Hits	19
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.073268 (rank : 572)
Query Neighborhood Hits	314	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.065371 (rank : 598)
Query Neighborhood Hits	314	Target Neighborhood Hits	142	Shared Neighborhood Hits	25
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.059778 (rank : 641)
Query Neighborhood Hits	314	Target Neighborhood Hits	120	Shared Neighborhood Hits	23
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.112778 (rank : 367)
Query Neighborhood Hits	314	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.112815 (rank : 365)
Query Neighborhood Hits	314	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.101454 (rank : 449)
Query Neighborhood Hits	314	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.104883 (rank : 431)
Query Neighborhood Hits	314	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.089879 (rank : 495)
Query Neighborhood Hits	314	Target Neighborhood Hits	187	Shared Neighborhood Hits	22
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.095433 (rank : 474)
Query Neighborhood Hits	314	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.089132 (rank : 499)
Query Neighborhood Hits	314	Target Neighborhood Hits	375	Shared Neighborhood Hits	39
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.090759 (rank : 489)
Query Neighborhood Hits	314	Target Neighborhood Hits	351	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.090075 (rank : 494)
Query Neighborhood Hits	314	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.057634 (rank : 687)
Query Neighborhood Hits	314	Target Neighborhood Hits	214	Shared Neighborhood Hits	22
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.098542 (rank : 459)
Query Neighborhood Hits	314	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.112935 (rank : 362)
Query Neighborhood Hits	314	Target Neighborhood Hits	152	Shared Neighborhood Hits	56
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

AURKC_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.050204 (rank : 889)
Query Neighborhood Hits	314	Target Neighborhood Hits	844	Shared Neighborhood Hits	50
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AVR2A_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.064579 (rank : 601)
Query Neighborhood Hits	314	Target Neighborhood Hits	767	Shared Neighborhood Hits	50
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.064581 (rank : 600)
Query Neighborhood Hits	314	Target Neighborhood Hits	767	Shared Neighborhood Hits	50
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2B_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.065397 (rank : 597)
Query Neighborhood Hits	314	Target Neighborhood Hits	748	Shared Neighborhood Hits	50
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.065484 (rank : 596)
Query Neighborhood Hits	314	Target Neighborhood Hits	749	Shared Neighborhood Hits	50
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

BCR_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.077171 (rank : 556)
Query Neighborhood Hits	314	Target Neighborhood Hits	204	Shared Neighborhood Hits	31
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.092380 (rank : 484)
Query Neighborhood Hits	314	Target Neighborhood Hits	156	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.080284 (rank : 543)
Query Neighborhood Hits	314	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.089040 (rank : 500)
Query Neighborhood Hits	314	Target Neighborhood Hits	335	Shared Neighborhood Hits	65
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.088030 (rank : 508)
Query Neighborhood Hits	314	Target Neighborhood Hits	283	Shared Neighborhood Hits	65
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLNK_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.139564 (rank : 312)
Query Neighborhood Hits	314	Target Neighborhood Hits	228	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.147211 (rank : 308)
Query Neighborhood Hits	314	Target Neighborhood Hits	296	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMP2K_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.051282 (rank : 847)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMPR2_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.068401 (rank : 586)
Query Neighborhood Hits	314	Target Neighborhood Hits	736	Shared Neighborhood Hits	51
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.067888 (rank : 588)
Query Neighborhood Hits	314	Target Neighborhood Hits	738	Shared Neighborhood Hits	51
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.086579 (rank : 515)
Query Neighborhood Hits	314	Target Neighborhood Hits	759	Shared Neighborhood Hits	50
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.086810 (rank : 513)
Query Neighborhood Hits	314	Target Neighborhood Hits	758	Shared Neighborhood Hits	50
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.088066 (rank : 507)
Query Neighborhood Hits	314	Target Neighborhood Hits	760	Shared Neighborhood Hits	48
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.088172 (rank : 506)
Query Neighborhood Hits	314	Target Neighborhood Hits	758	Shared Neighborhood Hits	48
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BRAF1_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.096849 (rank : 466)
Query Neighborhood Hits	314	Target Neighborhood Hits	883	Shared Neighborhood Hits	62
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BRSK1_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.056933 (rank : 703)
Query Neighborhood Hits	314	Target Neighborhood Hits	942	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.058571 (rank : 669)
Query Neighborhood Hits	314	Target Neighborhood Hits	897	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

CD2L5_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.058231 (rank : 678)
Query Neighborhood Hits	314	Target Neighborhood Hits	987	Shared Neighborhood Hits	55
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.057859 (rank : 686)
Query Neighborhood Hits	314	Target Neighborhood Hits	1011	Shared Neighborhood Hits	52
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.058798 (rank : 666)
Query Neighborhood Hits	314	Target Neighborhood Hits	1275	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDC2_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.053969 (rank : 784)
Query Neighborhood Hits	314	Target Neighborhood Hits	842	Shared Neighborhood Hits	50
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.053793 (rank : 788)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK2_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.052723 (rank : 809)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.052457 (rank : 819)
Query Neighborhood Hits	314	Target Neighborhood Hits	828	Shared Neighborhood Hits	50
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.055311 (rank : 753)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	50
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK3_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.055602 (rank : 740)
Query Neighborhood Hits	314	Target Neighborhood Hits	829	Shared Neighborhood Hits	50
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK5_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.054613 (rank : 767)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.054690 (rank : 764)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK6_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.050823 (rank : 863)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.051876 (rank : 833)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDK9_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.055961 (rank : 735)
Query Neighborhood Hits	314	Target Neighborhood Hits	822	Shared Neighborhood Hits	50
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.056083 (rank : 733)
Query Neighborhood Hits	314	Target Neighborhood Hits	822	Shared Neighborhood Hits	50
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDKL2_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.051504 (rank : 839)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.051001 (rank : 857)
Query Neighborhood Hits	314	Target Neighborhood Hits	854	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL4_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.050108 (rank : 891)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CHIN_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.173634 (rank : 293)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	105
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.053523 (rank : 791)
Query Neighborhood Hits	314	Target Neighborhood Hits	130	Shared Neighborhood Hits	20
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHK1_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.050566 (rank : 875)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	51
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.050054 (rank : 894)
Query Neighborhood Hits	314	Target Neighborhood Hits	839	Shared Neighborhood Hits	50
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CI096_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.071577 (rank : 578)
Query Neighborhood Hits	314	Target Neighborhood Hits	821	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CIP4_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.213000 (rank : 248)
Query Neighborhood Hits	314	Target Neighborhood Hits	374	Shared Neighborhood Hits	89
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CSF1R_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.114666 (rank : 352)
Query Neighborhood Hits	314	Target Neighborhood Hits	943	Shared Neighborhood Hits	50
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.111496 (rank : 389)
Query Neighborhood Hits	314	Target Neighborhood Hits	983	Shared Neighborhood Hits	50
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

DAPK1_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.050444 (rank : 877)
Query Neighborhood Hits	314	Target Neighborhood Hits	1138	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.050806 (rank : 865)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.050713 (rank : 867)
Query Neighborhood Hits	314	Target Neighborhood Hits	834	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.053364 (rank : 796)
Query Neighborhood Hits	314	Target Neighborhood Hits	945	Shared Neighborhood Hits	54
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.052749 (rank : 808)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	53
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DDR1_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.117748 (rank : 334)
Query Neighborhood Hits	314	Target Neighborhood Hits	819	Shared Neighborhood Hits	52
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.118278 (rank : 332)
Query Neighborhood Hits	314	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.112884 (rank : 364)
Query Neighborhood Hits	314	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.112444 (rank : 373)
Query Neighborhood Hits	314	Target Neighborhood Hits	813	Shared Neighborhood Hits	50
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DOCK1_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.112132 (rank : 378)
Query Neighborhood Hits	314	Target Neighborhood Hits	191	Shared Neighborhood Hits	111
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DUET_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.073791 (rank : 570)
Query Neighborhood Hits	314	Target Neighborhood Hits	1220	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

E2AK1_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.058278 (rank : 677)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.053965 (rank : 785)
Query Neighborhood Hits	314	Target Neighborhood Hits	821	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.057916 (rank : 684)
Query Neighborhood Hits	314	Target Neighborhood Hits	856	Shared Neighborhood Hits	50
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.062385 (rank : 618)
Query Neighborhood Hits	314	Target Neighborhood Hits	864	Shared Neighborhood Hits	50
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK3_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.056192 (rank : 728)
Query Neighborhood Hits	314	Target Neighborhood Hits	859	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.055530 (rank : 745)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

ECT2_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.093389 (rank : 481)
Query Neighborhood Hits	314	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.096792 (rank : 467)
Query Neighborhood Hits	314	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EGFR_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.112077 (rank : 380)
Query Neighborhood Hits	314	Target Neighborhood Hits	939	Shared Neighborhood Hits	51
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.112048 (rank : 381)
Query Neighborhood Hits	314	Target Neighborhood Hits	927	Shared Neighborhood Hits	50
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.111962 (rank : 382)
Query Neighborhood Hits	314	Target Neighborhood Hits	997	Shared Neighborhood Hits	56
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.112720 (rank : 368)
Query Neighborhood Hits	314	Target Neighborhood Hits	958	Shared Neighborhood Hits	57
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.110154 (rank : 398)
Query Neighborhood Hits	314	Target Neighborhood Hits	1021	Shared Neighborhood Hits	60
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.110506 (rank : 396)
Query Neighborhood Hits	314	Target Neighborhood Hits	1020	Shared Neighborhood Hits	60
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.105749 (rank : 426)
Query Neighborhood Hits	314	Target Neighborhood Hits	1005	Shared Neighborhood Hits	53
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.105985 (rank : 425)
Query Neighborhood Hits	314	Target Neighborhood Hits	1009	Shared Neighborhood Hits	53
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.108179 (rank : 415)
Query Neighborhood Hits	314	Target Neighborhood Hits	975	Shared Neighborhood Hits	55
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.108200 (rank : 414)
Query Neighborhood Hits	314	Target Neighborhood Hits	982	Shared Neighborhood Hits	55
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.107665 (rank : 416)
Query Neighborhood Hits	314	Target Neighborhood Hits	1009	Shared Neighborhood Hits	58
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.112081 (rank : 379)
Query Neighborhood Hits	314	Target Neighborhood Hits	950	Shared Neighborhood Hits	56
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.112902 (rank : 363)
Query Neighborhood Hits	314	Target Neighborhood Hits	959	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.112784 (rank : 366)
Query Neighborhood Hits	314	Target Neighborhood Hits	946	Shared Neighborhood Hits	56
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.105999 (rank : 424)
Query Neighborhood Hits	314	Target Neighborhood Hits	1053	Shared Neighborhood Hits	58
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.106112 (rank : 423)
Query Neighborhood Hits	314	Target Neighborhood Hits	1025	Shared Neighborhood Hits	57
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.108601 (rank : 411)
Query Neighborhood Hits	314	Target Neighborhood Hits	956	Shared Neighborhood Hits	57
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.108928 (rank : 408)
Query Neighborhood Hits	314	Target Neighborhood Hits	969	Shared Neighborhood Hits	58
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.116694 (rank : 338)
Query Neighborhood Hits	314	Target Neighborhood Hits	960	Shared Neighborhood Hits	58
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.107209 (rank : 419)
Query Neighborhood Hits	314	Target Neighborhood Hits	988	Shared Neighborhood Hits	57
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.108355 (rank : 412)
Query Neighborhood Hits	314	Target Neighborhood Hits	983	Shared Neighborhood Hits	56
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.108348 (rank : 413)
Query Neighborhood Hits	314	Target Neighborhood Hits	982	Shared Neighborhood Hits	56
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.109259 (rank : 405)
Query Neighborhood Hits	314	Target Neighborhood Hits	996	Shared Neighborhood Hits	59
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.109401 (rank : 403)
Query Neighborhood Hits	314	Target Neighborhood Hits	996	Shared Neighborhood Hits	59
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.109034 (rank : 406)
Query Neighborhood Hits	314	Target Neighborhood Hits	1056	Shared Neighborhood Hits	57
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.108625 (rank : 410)
Query Neighborhood Hits	314	Target Neighborhood Hits	1013	Shared Neighborhood Hits	57
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.117265 (rank : 335)
Query Neighborhood Hits	314	Target Neighborhood Hits	912	Shared Neighborhood Hits	57
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.116050 (rank : 340)
Query Neighborhood Hits	314	Target Neighborhood Hits	906	Shared Neighborhood Hits	55
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.115185 (rank : 346)
Query Neighborhood Hits	314	Target Neighborhood Hits	1073	Shared Neighborhood Hits	53
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 466)	NC score	0.115167 (rank : 347)
Query Neighborhood Hits	314	Target Neighborhood Hits	918	Shared Neighborhood Hits	52
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.116010 (rank : 342)
Query Neighborhood Hits	314	Target Neighborhood Hits	918	Shared Neighborhood Hits	51
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.115650 (rank : 343)
Query Neighborhood Hits	314	Target Neighborhood Hits	898	Shared Neighborhood Hits	51
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.114903 (rank : 351)
Query Neighborhood Hits	314	Target Neighborhood Hits	910	Shared Neighborhood Hits	53
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L3_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.328701 (rank : 138)
Query Neighborhood Hits	314	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FAK1_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.113429 (rank : 361)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.113433 (rank : 360)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.117913 (rank : 333)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.117250 (rank : 336)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FARP2_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.055370 (rank : 752)
Query Neighborhood Hits	314	Target Neighborhood Hits	209	Shared Neighborhood Hits	25
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FES_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.156378 (rank : 299)
Query Neighborhood Hits	314	Target Neighborhood Hits	978	Shared Neighborhood Hits	108
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.059315 (rank : 651)
Query Neighborhood Hits	314	Target Neighborhood Hits	387	Shared Neighborhood Hits	30
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.066624 (rank : 590)
Query Neighborhood Hits	314	Target Neighborhood Hits	151	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.063676 (rank : 605)
Query Neighborhood Hits	314	Target Neighborhood Hits	163	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.070856 (rank : 580)
Query Neighborhood Hits	314	Target Neighborhood Hits	249	Shared Neighborhood Hits	21
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.075077 (rank : 564)
Query Neighborhood Hits	314	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.069603 (rank : 582)
Query Neighborhood Hits	314	Target Neighborhood Hits	219	Shared Neighborhood Hits	26
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.070397 (rank : 581)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.050236 (rank : 887)
Query Neighborhood Hits	314	Target Neighborhood Hits	237	Shared Neighborhood Hits	22
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.055578 (rank : 742)
Query Neighborhood Hits	314	Target Neighborhood Hits	282	Shared Neighborhood Hits	27
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGFR1_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.102701 (rank : 446)
Query Neighborhood Hits	314	Target Neighborhood Hits	1069	Shared Neighborhood Hits	51
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.102712 (rank : 445)
Query Neighborhood Hits	314	Target Neighborhood Hits	1068	Shared Neighborhood Hits	51
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.103046 (rank : 442)
Query Neighborhood Hits	314	Target Neighborhood Hits	1062	Shared Neighborhood Hits	50
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.103520 (rank : 441)
Query Neighborhood Hits	314	Target Neighborhood Hits	1062	Shared Neighborhood Hits	50
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.104414 (rank : 436)
Query Neighborhood Hits	314	Target Neighborhood Hits	1042	Shared Neighborhood Hits	51
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.103680 (rank : 440)
Query Neighborhood Hits	314	Target Neighborhood Hits	1059	Shared Neighborhood Hits	50
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.106900 (rank : 420)
Query Neighborhood Hits	314	Target Neighborhood Hits	1037	Shared Neighborhood Hits	50
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.108970 (rank : 407)
Query Neighborhood Hits	314	Target Neighborhood Hits	1026	Shared Neighborhood Hits	50
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLT3_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.115635 (rank : 344)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	50
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.116298 (rank : 339)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

GAK_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.051102 (rank : 854)
Query Neighborhood Hits	314	Target Neighborhood Hits	1028	Shared Neighborhood Hits	59
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GNRP_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.068055 (rank : 587)
Query Neighborhood Hits	314	Target Neighborhood Hits	239	Shared Neighborhood Hits	22
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.075109 (rank : 563)
Query Neighborhood Hits	314	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRIP1_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.059074 (rank : 660)
Query Neighborhood Hits	314	Target Neighborhood Hits	231	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.060009 (rank : 635)
Query Neighborhood Hits	314	Target Neighborhood Hits	241	Shared Neighborhood Hits	28
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP2_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.057173 (rank : 695)
Query Neighborhood Hits	314	Target Neighborhood Hits	256	Shared Neighborhood Hits	25
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GUC2C_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.098862 (rank : 458)
Query Neighborhood Hits	314	Target Neighborhood Hits	624	Shared Neighborhood Hits	48
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.088922 (rank : 502)
Query Neighborhood Hits	314	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.088683 (rank : 503)
Query Neighborhood Hits	314	Target Neighborhood Hits	692	Shared Neighborhood Hits	47
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.101669 (rank : 448)
Query Neighborhood Hits	314	Target Neighborhood Hits	740	Shared Neighborhood Hits	48
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.091751 (rank : 486)
Query Neighborhood Hits	314	Target Neighborhood Hits	644	Shared Neighborhood Hits	45
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HAPIP_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.073969 (rank : 569)
Query Neighborhood Hits	314	Target Neighborhood Hits	350	Shared Neighborhood Hits	26
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HIPK4_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.051849 (rank : 834)
Query Neighborhood Hits	314	Target Neighborhood Hits	799	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

HUNK_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.053824 (rank : 787)
Query Neighborhood Hits	314	Target Neighborhood Hits	884	Shared Neighborhood Hits	50
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.054014 (rank : 783)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

IASPP_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.224941 (rank : 240)
Query Neighborhood Hits	314	Target Neighborhood Hits	688	Shared Neighborhood Hits	155
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.206241 (rank : 254)
Query Neighborhood Hits	314	Target Neighborhood Hits	1024	Shared Neighborhood Hits	165
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ICK_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.059170 (rank : 657)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.058925 (rank : 662)
Query Neighborhood Hits	314	Target Neighborhood Hits	860	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

IGF1R_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.114939 (rank : 350)
Query Neighborhood Hits	314	Target Neighborhood Hits	977	Shared Neighborhood Hits	51
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.114977 (rank : 349)
Query Neighborhood Hits	314	Target Neighborhood Hits	973	Shared Neighborhood Hits	51
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IKKA_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.059203 (rank : 655)
Query Neighborhood Hits	314	Target Neighborhood Hits	863	Shared Neighborhood Hits	50
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.058136 (rank : 683)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	50
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.055385 (rank : 751)
Query Neighborhood Hits	314	Target Neighborhood Hits	980	Shared Neighborhood Hits	50
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.054321 (rank : 773)
Query Neighborhood Hits	314	Target Neighborhood Hits	984	Shared Neighborhood Hits	53
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.054308 (rank : 774)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.056515 (rank : 719)
Query Neighborhood Hits	314	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

ILK1_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.109947 (rank : 399)
Query Neighborhood Hits	314	Target Neighborhood Hits	857	Shared Neighborhood Hits	63
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.108915 (rank : 409)
Query Neighborhood Hits	314	Target Neighborhood Hits	848	Shared Neighborhood Hits	63
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.110934 (rank : 392)
Query Neighborhood Hits	314	Target Neighborhood Hits	858	Shared Neighborhood Hits	63
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INADL_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.051516 (rank : 838)
Query Neighborhood Hits	314	Target Neighborhood Hits	260	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.052293 (rank : 824)
Query Neighborhood Hits	314	Target Neighborhood Hits	290	Shared Neighborhood Hits	28
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

INSRR_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.114452 (rank : 353)
Query Neighborhood Hits	314	Target Neighborhood Hits	950	Shared Neighborhood Hits	51
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.114013 (rank : 356)
Query Neighborhood Hits	314	Target Neighborhood Hits	961	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.112349 (rank : 375)
Query Neighborhood Hits	314	Target Neighborhood Hits	963	Shared Neighborhood Hits	51
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.111870 (rank : 384)
Query Neighborhood Hits	314	Target Neighborhood Hits	968	Shared Neighborhood Hits	51
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK1_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.085504 (rank : 521)
Query Neighborhood Hits	314	Target Neighborhood Hits	820	Shared Neighborhood Hits	50
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.089791 (rank : 498)
Query Neighborhood Hits	314	Target Neighborhood Hits	784	Shared Neighborhood Hits	48
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.080120 (rank : 547)
Query Neighborhood Hits	314	Target Neighborhood Hits	714	Shared Neighborhood Hits	50
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.090617 (rank : 490)
Query Neighborhood Hits	314	Target Neighborhood Hits	644	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.095827 (rank : 473)
Query Neighborhood Hits	314	Target Neighborhood Hits	628	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.084658 (rank : 524)
Query Neighborhood Hits	314	Target Neighborhood Hits	816	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.082010 (rank : 534)
Query Neighborhood Hits	314	Target Neighborhood Hits	820	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

JAK1_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.103936 (rank : 439)
Query Neighborhood Hits	314	Target Neighborhood Hits	858	Shared Neighborhood Hits	57
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.104796 (rank : 432)
Query Neighborhood Hits	314	Target Neighborhood Hits	854	Shared Neighborhood Hits	57
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.096934 (rank : 464)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	52
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.097659 (rank : 461)
Query Neighborhood Hits	314	Target Neighborhood Hits	839	Shared Neighborhood Hits	53
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.099801 (rank : 452)
Query Neighborhood Hits	314	Target Neighborhood Hits	827	Shared Neighborhood Hits	50
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.096123 (rank : 471)
Query Neighborhood Hits	314	Target Neighborhood Hits	821	Shared Neighborhood Hits	50
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

JIP2_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.078549 (rank : 552)
Query Neighborhood Hits	314	Target Neighborhood Hits	288	Shared Neighborhood Hits	61
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.079136 (rank : 550)
Query Neighborhood Hits	314	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

K0999_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.055300 (rank : 754)
Query Neighborhood Hits	314	Target Neighborhood Hits	899	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.055562 (rank : 743)
Query Neighborhood Hits	314	Target Neighborhood Hits	931	Shared Neighborhood Hits	53
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KC1AL_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.052486 (rank : 817)
Query Neighborhood Hits	314	Target Neighborhood Hits	734	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KC1A_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.050419 (rank : 878)
Query Neighborhood Hits	314	Target Neighborhood Hits	728	Shared Neighborhood Hits	47
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.050419 (rank : 879)
Query Neighborhood Hits	314	Target Neighborhood Hits	728	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1D_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.059238 (rank : 653)
Query Neighborhood Hits	314	Target Neighborhood Hits	737	Shared Neighborhood Hits	47
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.059232 (rank : 654)
Query Neighborhood Hits	314	Target Neighborhood Hits	737	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.056678 (rank : 713)
Query Neighborhood Hits	314	Target Neighborhood Hits	732	Shared Neighborhood Hits	45
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.056684 (rank : 711)
Query Neighborhood Hits	314	Target Neighborhood Hits	728	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KGUA_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.154848 (rank : 302)
Query Neighborhood Hits	314	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.155901 (rank : 300)
Query Neighborhood Hits	314	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KIT_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.111502 (rank : 387)
Query Neighborhood Hits	314	Target Neighborhood Hits	953	Shared Neighborhood Hits	50
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.112448 (rank : 372)
Query Neighborhood Hits	314	Target Neighborhood Hits	949	Shared Neighborhood Hits	51
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KPCA_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.059780 (rank : 640)
Query Neighborhood Hits	314	Target Neighborhood Hits	1070	Shared Neighborhood Hits	70
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.060231 (rank : 634)
Query Neighborhood Hits	314	Target Neighborhood Hits	1067	Shared Neighborhood Hits	70
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.061930 (rank : 622)
Query Neighborhood Hits	314	Target Neighborhood Hits	1121	Shared Neighborhood Hits	68
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.062473 (rank : 616)
Query Neighborhood Hits	314	Target Neighborhood Hits	1117	Shared Neighborhood Hits	68
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCD1_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.054833 (rank : 761)
Query Neighborhood Hits	314	Target Neighborhood Hits	901	Shared Neighborhood Hits	62
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD1_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.054174 (rank : 780)
Query Neighborhood Hits	314	Target Neighborhood Hits	891	Shared Neighborhood Hits	62
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD2_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.056512 (rank : 720)
Query Neighborhood Hits	314	Target Neighborhood Hits	910	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCD3_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.055557 (rank : 744)
Query Neighborhood Hits	314	Target Neighborhood Hits	895	Shared Neighborhood Hits	62
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.055261 (rank : 757)
Query Neighborhood Hits	314	Target Neighborhood Hits	901	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KPCD_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.059666 (rank : 644)
Query Neighborhood Hits	314	Target Neighborhood Hits	900	Shared Neighborhood Hits	62
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.058800 (rank : 665)
Query Neighborhood Hits	314	Target Neighborhood Hits	888	Shared Neighborhood Hits	62
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCE_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.052402 (rank : 823)
Query Neighborhood Hits	314	Target Neighborhood Hits	906	Shared Neighborhood Hits	64
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.052760 (rank : 805)
Query Neighborhood Hits	314	Target Neighborhood Hits	906	Shared Neighborhood Hits	63
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCG_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.056824 (rank : 707)
Query Neighborhood Hits	314	Target Neighborhood Hits	1126	Shared Neighborhood Hits	70
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.056912 (rank : 704)
Query Neighborhood Hits	314	Target Neighborhood Hits	1123	Shared Neighborhood Hits	70
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCT_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.058296 (rank : 676)
Query Neighborhood Hits	314	Target Neighborhood Hits	897	Shared Neighborhood Hits	62
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.057013 (rank : 699)
Query Neighborhood Hits	314	Target Neighborhood Hits	895	Shared Neighborhood Hits	62
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KS6A3_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.050233 (rank : 888)
Query Neighborhood Hits	314	Target Neighborhood Hits	859	Shared Neighborhood Hits	50
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.050240 (rank : 886)
Query Neighborhood Hits	314	Target Neighborhood Hits	860	Shared Neighborhood Hits	50
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KSR1_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.091543 (rank : 488)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.089874 (rank : 496)
Query Neighborhood Hits	314	Target Neighborhood Hits	870	Shared Neighborhood Hits	56
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.092012 (rank : 485)
Query Neighborhood Hits	314	Target Neighborhood Hits	920	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

LBC_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.073094 (rank : 573)
Query Neighborhood Hits	314	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LIMK1_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.084293 (rank : 525)
Query Neighborhood Hits	314	Target Neighborhood Hits	1005	Shared Neighborhood Hits	64
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.084046 (rank : 526)
Query Neighborhood Hits	314	Target Neighborhood Hits	1008	Shared Neighborhood Hits	64
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.081423 (rank : 539)
Query Neighborhood Hits	314	Target Neighborhood Hits	986	Shared Neighborhood Hits	66
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.081650 (rank : 537)
Query Neighborhood Hits	314	Target Neighborhood Hits	998	Shared Neighborhood Hits	64
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIN7A_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.059361 (rank : 649)
Query Neighborhood Hits	314	Target Neighborhood Hits	193	Shared Neighborhood Hits	25
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.059453 (rank : 648)
Query Neighborhood Hits	314	Target Neighborhood Hits	193	Shared Neighborhood Hits	25
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.060584 (rank : 632)
Query Neighborhood Hits	314	Target Neighborhood Hits	200	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.060608 (rank : 628)
Query Neighborhood Hits	314	Target Neighborhood Hits	200	Shared Neighborhood Hits	27
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.060585 (rank : 630)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.060585 (rank : 631)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LMO7_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.050344 (rank : 882)
Query Neighborhood Hits	314	Target Neighborhood Hits	507	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LRRK1_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.074255 (rank : 567)
Query Neighborhood Hits	314	Target Neighborhood Hits	1237	Shared Neighborhood Hits	56
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.074454 (rank : 566)
Query Neighborhood Hits	314	Target Neighborhood Hits	1267	Shared Neighborhood Hits	55
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.072096 (rank : 576)
Query Neighborhood Hits	314	Target Neighborhood Hits	1382	Shared Neighborhood Hits	50
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.072186 (rank : 575)
Query Neighborhood Hits	314	Target Neighborhood Hits	1359	Shared Neighborhood Hits	52
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.124909 (rank : 322)
Query Neighborhood Hits	314	Target Neighborhood Hits	774	Shared Neighborhood Hits	50
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 599)	NC score	0.124002 (rank : 325)
Query Neighborhood Hits	314	Target Neighborhood Hits	770	Shared Neighborhood Hits	51
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K12_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.090459 (rank : 491)
Query Neighborhood Hits	314	Target Neighborhood Hits	940	Shared Neighborhood Hits	53
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.090329 (rank : 492)
Query Neighborhood Hits	314	Target Neighborhood Hits	957	Shared Neighborhood Hits	54
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.089863 (rank : 497)
Query Neighborhood Hits	314	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K15_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.056277 (rank : 727)
Query Neighborhood Hits	314	Target Neighborhood Hits	914	Shared Neighborhood Hits	51
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.052463 (rank : 818)
Query Neighborhood Hits	314	Target Neighborhood Hits	952	Shared Neighborhood Hits	53
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.054481 (rank : 771)
Query Neighborhood Hits	314	Target Neighborhood Hits	849	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.052446 (rank : 820)
Query Neighborhood Hits	314	Target Neighborhood Hits	846	Shared Neighborhood Hits	51
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.057160 (rank : 696)
Query Neighborhood Hits	314	Target Neighborhood Hits	885	Shared Neighborhood Hits	53
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.056678 (rank : 714)
Query Neighborhood Hits	314	Target Neighborhood Hits	876	Shared Neighborhood Hits	53
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.051493 (rank : 840)
Query Neighborhood Hits	314	Target Neighborhood Hits	911	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.050683 (rank : 870)
Query Neighborhood Hits	314	Target Neighborhood Hits	924	Shared Neighborhood Hits	51
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.053396 (rank : 795)
Query Neighborhood Hits	314	Target Neighborhood Hits	868	Shared Neighborhood Hits	50
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.053510 (rank : 792)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	50
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.051489 (rank : 841)
Query Neighborhood Hits	314	Target Neighborhood Hits	889	Shared Neighborhood Hits	50
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K7_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.087331 (rank : 511)
Query Neighborhood Hits	314	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 615)	NC score	0.087363 (rank : 510)
Query Neighborhood Hits	314	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M4K1_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.052824 (rank : 804)
Query Neighborhood Hits	314	Target Neighborhood Hits	884	Shared Neighborhood Hits	50
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.053933 (rank : 786)
Query Neighborhood Hits	314	Target Neighborhood Hits	858	Shared Neighborhood Hits	51
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K3_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.050407 (rank : 880)
Query Neighborhood Hits	314	Target Neighborhood Hits	857	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K4_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.054681 (rank : 766)
Query Neighborhood Hits	314	Target Neighborhood Hits	1589	Shared Neighborhood Hits	68
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.060667 (rank : 626)
Query Neighborhood Hits	314	Target Neighborhood Hits	1560	Shared Neighborhood Hits	68
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K5_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.050077 (rank : 892)
Query Neighborhood Hits	314	Target Neighborhood Hits	845	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M4K5_MOUSE
θ value	θ > 10 (rank : 622)	NC score	0.050021 (rank : 895)
Query Neighborhood Hits	314	Target Neighborhood Hits	839	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MAK_HUMAN
θ value	θ > 10 (rank : 623)	NC score	0.058395 (rank : 674)
Query Neighborhood Hits	314	Target Neighborhood Hits	857	Shared Neighborhood Hits	52
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 624)	NC score	0.059504 (rank : 647)
Query Neighborhood Hits	314	Target Neighborhood Hits	873	Shared Neighborhood Hits	52
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MARK1_HUMAN
θ value	θ > 10 (rank : 625)	NC score	0.056138 (rank : 730)
Query Neighborhood Hits	314	Target Neighborhood Hits	887	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 626)	NC score	0.056336 (rank : 724)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.056376 (rank : 723)
Query Neighborhood Hits	314	Target Neighborhood Hits	1056	Shared Neighborhood Hits	56
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 628)	NC score	0.055169 (rank : 758)
Query Neighborhood Hits	314	Target Neighborhood Hits	1018	Shared Neighborhood Hits	54
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.056592 (rank : 716)
Query Neighborhood Hits	314	Target Neighborhood Hits	893	Shared Neighborhood Hits	54
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 630)	NC score	0.056471 (rank : 722)
Query Neighborhood Hits	314	Target Neighborhood Hits	919	Shared Neighborhood Hits	54
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.056871 (rank : 706)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 632)	NC score	0.056888 (rank : 705)
Query Neighborhood Hits	314	Target Neighborhood Hits	898	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MASTL_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.050660 (rank : 871)
Query Neighborhood Hits	314	Target Neighborhood Hits	862	Shared Neighborhood Hits	50
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MCF2L_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.126199 (rank : 318)
Query Neighborhood Hits	314	Target Neighborhood Hits	255	Shared Neighborhood Hits	49
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.095945 (rank : 472)
Query Neighborhood Hits	314	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MELK_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.050727 (rank : 866)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.051022 (rank : 856)
Query Neighborhood Hits	314	Target Neighborhood Hits	860	Shared Neighborhood Hits	50
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MERTK_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.114145 (rank : 355)
Query Neighborhood Hits	314	Target Neighborhood Hits	988	Shared Neighborhood Hits	49
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.113562 (rank : 358)
Query Neighborhood Hits	314	Target Neighborhood Hits	974	Shared Neighborhood Hits	49
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.110176 (rank : 397)
Query Neighborhood Hits	314	Target Neighborhood Hits	831	Shared Neighborhood Hits	50
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.110584 (rank : 395)
Query Neighborhood Hits	314	Target Neighborhood Hits	844	Shared Neighborhood Hits	50
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MINK1_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.056135 (rank : 731)
Query Neighborhood Hits	314	Target Neighborhood Hits	1477	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.056152 (rank : 729)
Query Neighborhood Hits	314	Target Neighborhood Hits	1451	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK01_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.052701 (rank : 811)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	50
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.052896 (rank : 803)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	50
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.051298 (rank : 846)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.051390 (rank : 843)
Query Neighborhood Hits	314	Target Neighborhood Hits	840	Shared Neighborhood Hits	50
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK04_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.054059 (rank : 782)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	51
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.053141 (rank : 801)
Query Neighborhood Hits	314	Target Neighborhood Hits	852	Shared Neighborhood Hits	52
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK06_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.051199 (rank : 850)
Query Neighborhood Hits	314	Target Neighborhood Hits	815	Shared Neighborhood Hits	49
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	θ > 10 (rank : 651)	NC score	0.050978 (rank : 858)
Query Neighborhood Hits	314	Target Neighborhood Hits	818	Shared Neighborhood Hits	49
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK11_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.055296 (rank : 755)
Query Neighborhood Hits	314	Target Neighborhood Hits	823	Shared Neighborhood Hits	50
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MK11_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.051330 (rank : 844)
Query Neighborhood Hits	314	Target Neighborhood Hits	835	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK12_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.052171 (rank : 826)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	51
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
θ value	θ > 10 (rank : 655)	NC score	0.052098 (rank : 827)
Query Neighborhood Hits	314	Target Neighborhood Hits	835	Shared Neighborhood Hits	51
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK14_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.054068 (rank : 781)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	θ > 10 (rank : 657)	NC score	0.053701 (rank : 790)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MLKL_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.106235 (rank : 422)
Query Neighborhood Hits	314	Target Neighborhood Hits	600	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.104291 (rank : 438)
Query Neighborhood Hits	314	Target Neighborhood Hits	707	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.095207 (rank : 476)
Query Neighborhood Hits	314	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.095269 (rank : 475)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.094071 (rank : 478)
Query Neighborhood Hits	314	Target Neighborhood Hits	829	Shared Neighborhood Hits	50
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.092752 (rank : 483)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K1_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.057228 (rank : 693)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 665)	NC score	0.057382 (rank : 691)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.059333 (rank : 650)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.059269 (rank : 652)
Query Neighborhood Hits	314	Target Neighborhood Hits	828	Shared Neighborhood Hits	50
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.055433 (rank : 748)
Query Neighborhood Hits	314	Target Neighborhood Hits	825	Shared Neighborhood Hits	50
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.056292 (rank : 726)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.056792 (rank : 708)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 671)	NC score	0.056697 (rank : 710)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.058215 (rank : 680)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 673)	NC score	0.060521 (rank : 633)
Query Neighborhood Hits	314	Target Neighborhood Hits	840	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.055155 (rank : 759)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.055291 (rank : 756)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.058846 (rank : 664)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.063354 (rank : 607)
Query Neighborhood Hits	314	Target Neighborhood Hits	852	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 678)	NC score	0.063228 (rank : 609)
Query Neighborhood Hits	314	Target Neighborhood Hits	860	Shared Neighborhood Hits	50
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MUSK_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.104671 (rank : 433)
Query Neighborhood Hits	314	Target Neighborhood Hits	1074	Shared Neighborhood Hits	50
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 680)	NC score	0.105061 (rank : 429)
Query Neighborhood Hits	314	Target Neighborhood Hits	1057	Shared Neighborhood Hits	50
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYLK2_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.062746 (rank : 612)
Query Neighborhood Hits	314	Target Neighborhood Hits	920	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYO3A_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.052434 (rank : 821)
Query Neighborhood Hits	314	Target Neighborhood Hits	1033	Shared Neighborhood Hits	54
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
θ value	θ > 10 (rank : 683)	NC score	0.051545 (rank : 837)
Query Neighborhood Hits	314	Target Neighborhood Hits	902	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

NEK11_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.069146 (rank : 584)
Query Neighborhood Hits	314	Target Neighborhood Hits	1043	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.069015 (rank : 585)
Query Neighborhood Hits	314	Target Neighborhood Hits	875	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.057423 (rank : 690)
Query Neighborhood Hits	314	Target Neighborhood Hits	1129	Shared Neighborhood Hits	56
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 687)	NC score	0.057329 (rank : 692)
Query Neighborhood Hits	314	Target Neighborhood Hits	1311	Shared Neighborhood Hits	58
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.056301 (rank : 725)
Query Neighborhood Hits	314	Target Neighborhood Hits	908	Shared Neighborhood Hits	52
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 689)	NC score	0.055579 (rank : 741)
Query Neighborhood Hits	314	Target Neighborhood Hits	876	Shared Neighborhood Hits	51
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.059664 (rank : 645)
Query Neighborhood Hits	314	Target Neighborhood Hits	865	Shared Neighborhood Hits	50
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.058429 (rank : 673)
Query Neighborhood Hits	314	Target Neighborhood Hits	854	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.059914 (rank : 636)
Query Neighborhood Hits	314	Target Neighborhood Hits	883	Shared Neighborhood Hits	50
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 693)	NC score	0.060589 (rank : 629)
Query Neighborhood Hits	314	Target Neighborhood Hits	899	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.062560 (rank : 615)
Query Neighborhood Hits	314	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 695)	NC score	0.062726 (rank : 613)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.062952 (rank : 610)
Query Neighborhood Hits	314	Target Neighborhood Hits	846	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.062865 (rank : 611)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.054824 (rank : 762)
Query Neighborhood Hits	314	Target Neighborhood Hits	872	Shared Neighborhood Hits	50
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.054487 (rank : 770)
Query Neighborhood Hits	314	Target Neighborhood Hits	872	Shared Neighborhood Hits	50
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.053233 (rank : 800)
Query Neighborhood Hits	314	Target Neighborhood Hits	900	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.052753 (rank : 807)
Query Neighborhood Hits	314	Target Neighborhood Hits	890	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NGEF_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.136629 (rank : 313)
Query Neighborhood Hits	314	Target Neighborhood Hits	166	Shared Neighborhood Hits	72
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 703)	NC score	0.140482 (rank : 311)
Query Neighborhood Hits	314	Target Neighborhood Hits	228	Shared Neighborhood Hits	78
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NIM1_HUMAN
θ value	θ > 10 (rank : 704)	NC score	0.056707 (rank : 709)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 705)	NC score	0.056558 (rank : 718)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NRK_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.050265 (rank : 884)
Query Neighborhood Hits	314	Target Neighborhood Hits	931	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.050608 (rank : 872)
Query Neighborhood Hits	314	Target Neighborhood Hits	899	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NTRK1_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.115040 (rank : 348)
Query Neighborhood Hits	314	Target Neighborhood Hits	1023	Shared Neighborhood Hits	50
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.107260 (rank : 418)
Query Neighborhood Hits	314	Target Neighborhood Hits	1081	Shared Neighborhood Hits	50
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 710)	NC score	0.107272 (rank : 417)
Query Neighborhood Hits	314	Target Neighborhood Hits	1088	Shared Neighborhood Hits	50
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.111287 (rank : 390)
Query Neighborhood Hits	314	Target Neighborhood Hits	1115	Shared Neighborhood Hits	50
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NUAK1_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.058147 (rank : 682)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	51
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 713)	NC score	0.058221 (rank : 679)
Query Neighborhood Hits	314	Target Neighborhood Hits	881	Shared Neighborhood Hits	50
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.056122 (rank : 732)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.054914 (rank : 760)
Query Neighborhood Hits	314	Target Neighborhood Hits	878	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

OXSR1_HUMAN
θ value	θ > 10 (rank : 716)	NC score	0.065985 (rank : 594)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 717)	NC score	0.066157 (rank : 593)
Query Neighborhood Hits	314	Target Neighborhood Hits	865	Shared Neighborhood Hits	50
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 718)	NC score	0.050072 (rank : 893)
Query Neighborhood Hits	314	Target Neighborhood Hits	873	Shared Neighborhood Hits	51
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK2_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.051892 (rank : 832)
Query Neighborhood Hits	314	Target Neighborhood Hits	862	Shared Neighborhood Hits	50
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.051915 (rank : 830)
Query Neighborhood Hits	314	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK4_MOUSE
θ value	θ > 10 (rank : 721)	NC score	0.051111 (rank : 853)
Query Neighborhood Hits	314	Target Neighborhood Hits	1098	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.051631 (rank : 836)
Query Neighborhood Hits	314	Target Neighborhood Hits	915	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.051971 (rank : 829)
Query Neighborhood Hits	314	Target Neighborhood Hits	875	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.051746 (rank : 835)
Query Neighborhood Hits	314	Target Neighborhood Hits	875	Shared Neighborhood Hits	50
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PAR3L_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.050115 (rank : 890)
Query Neighborhood Hits	314	Target Neighborhood Hits	297	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PAR6B_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.050812 (rank : 864)
Query Neighborhood Hits	314	Target Neighborhood Hits	126	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	θ > 10 (rank : 727)	NC score	0.051140 (rank : 852)
Query Neighborhood Hits	314	Target Neighborhood Hits	128	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PCTK1_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.054521 (rank : 769)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	θ > 10 (rank : 729)	NC score	0.054718 (rank : 763)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_HUMAN
θ value	θ > 10 (rank : 730)	NC score	0.054566 (rank : 768)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	51
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	θ > 10 (rank : 731)	NC score	0.054687 (rank : 765)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	θ > 10 (rank : 732)	NC score	0.052551 (rank : 816)
Query Neighborhood Hits	314	Target Neighborhood Hits	827	Shared Neighborhood Hits	50
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 733)	NC score	0.052638 (rank : 812)
Query Neighborhood Hits	314	Target Neighborhood Hits	834	Shared Neighborhood Hits	50
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PFTK1_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.055394 (rank : 750)
Query Neighborhood Hits	314	Target Neighborhood Hits	834	Shared Neighborhood Hits	50
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 735)	NC score	0.055789 (rank : 737)
Query Neighborhood Hits	314	Target Neighborhood Hits	835	Shared Neighborhood Hits	50
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PGFRA_HUMAN
θ value	θ > 10 (rank : 736)	NC score	0.111921 (rank : 383)
Query Neighborhood Hits	314	Target Neighborhood Hits	980	Shared Neighborhood Hits	50
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 737)	NC score	0.112244 (rank : 377)
Query Neighborhood Hits	314	Target Neighborhood Hits	975	Shared Neighborhood Hits	50
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 738)	NC score	0.112310 (rank : 376)
Query Neighborhood Hits	314	Target Neighborhood Hits	962	Shared Neighborhood Hits	50
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 739)	NC score	0.112599 (rank : 369)
Query Neighborhood Hits	314	Target Neighborhood Hits	960	Shared Neighborhood Hits	52
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PIM1_HUMAN
θ value	θ > 10 (rank : 740)	NC score	0.053322 (rank : 798)
Query Neighborhood Hits	314	Target Neighborhood Hits	797	Shared Neighborhood Hits	49
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_MOUSE
θ value	θ > 10 (rank : 741)	NC score	0.051222 (rank : 849)
Query Neighborhood Hits	314	Target Neighborhood Hits	787	Shared Neighborhood Hits	49
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PKHG1_HUMAN
θ value	θ > 10 (rank : 742)	NC score	0.125248 (rank : 320)
Query Neighborhood Hits	314	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.062586 (rank : 614)
Query Neighborhood Hits	314	Target Neighborhood Hits	200	Shared Neighborhood Hits	21
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PKN1_HUMAN
θ value	θ > 10 (rank : 744)	NC score	0.050694 (rank : 868)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	52
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 745)	NC score	0.050908 (rank : 860)
Query Neighborhood Hits	314	Target Neighborhood Hits	888	Shared Neighborhood Hits	51
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 746)	NC score	0.052717 (rank : 810)
Query Neighborhood Hits	314	Target Neighborhood Hits	892	Shared Neighborhood Hits	51
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 747)	NC score	0.052557 (rank : 815)
Query Neighborhood Hits	314	Target Neighborhood Hits	899	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PLCD1_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.052240 (rank : 825)
Query Neighborhood Hits	314	Target Neighborhood Hits	93	Shared Neighborhood Hits	5
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.054270 (rank : 776)
Query Neighborhood Hits	314	Target Neighborhood Hits	106	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLK2_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.054296 (rank : 775)
Query Neighborhood Hits	314	Target Neighborhood Hits	854	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.054370 (rank : 772)
Query Neighborhood Hits	314	Target Neighborhood Hits	849	Shared Neighborhood Hits	50
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.051184 (rank : 851)
Query Neighborhood Hits	314	Target Neighborhood Hits	884	Shared Neighborhood Hits	50
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.051226 (rank : 848)
Query Neighborhood Hits	314	Target Neighborhood Hits	879	Shared Neighborhood Hits	50
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PPIP2_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.079189 (rank : 549)
Query Neighborhood Hits	314	Target Neighborhood Hits	254	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 755)	NC score	0.071861 (rank : 577)
Query Neighborhood Hits	314	Target Neighborhood Hits	308	Shared Neighborhood Hits	19
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.116946 (rank : 337)
Query Neighborhood Hits	314	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRP4B_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.053474 (rank : 793)
Query Neighborhood Hits	314	Target Neighborhood Hits	1030	Shared Neighborhood Hits	56
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.053276 (rank : 799)
Query Neighborhood Hits	314	Target Neighborhood Hits	1040	Shared Neighborhood Hits	56
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PTK7_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.101290 (rank : 450)
Query Neighborhood Hits	314	Target Neighborhood Hits	1103	Shared Neighborhood Hits	50
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

RAF1_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.097066 (rank : 463)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 761)	NC score	0.096516 (rank : 469)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAPH1_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.072712 (rank : 574)
Query Neighborhood Hits	314	Target Neighborhood Hits	593	Shared Neighborhood Hits	40
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RET_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.111500 (rank : 388)
Query Neighborhood Hits	314	Target Neighborhood Hits	873	Shared Neighborhood Hits	50
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.110600 (rank : 394)
Query Neighborhood Hits	314	Target Neighborhood Hits	884	Shared Neighborhood Hits	50
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RGNEF_MOUSE
θ value	θ > 10 (rank : 765)	NC score	0.065768 (rank : 595)
Query Neighborhood Hits	314	Target Neighborhood Hits	641	Shared Neighborhood Hits	38
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG09_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.073417 (rank : 571)
Query Neighborhood Hits	314	Target Neighborhood Hits	186	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.086202 (rank : 520)
Query Neighborhood Hits	314	Target Neighborhood Hits	190	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.086512 (rank : 518)
Query Neighborhood Hits	314	Target Neighborhood Hits	204	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG26_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.191475 (rank : 277)
Query Neighborhood Hits	314	Target Neighborhood Hits	281	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIPK1_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.091632 (rank : 487)
Query Neighborhood Hits	314	Target Neighborhood Hits	891	Shared Neighborhood Hits	50
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 771)	NC score	0.093260 (rank : 482)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	51
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.086227 (rank : 519)
Query Neighborhood Hits	314	Target Neighborhood Hits	774	Shared Neighborhood Hits	50
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 773)	NC score	0.087721 (rank : 509)
Query Neighborhood Hits	314	Target Neighborhood Hits	776	Shared Neighborhood Hits	50
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.086875 (rank : 512)
Query Neighborhood Hits	314	Target Neighborhood Hits	828	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 775)	NC score	0.086549 (rank : 516)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.075430 (rank : 562)
Query Neighborhood Hits	314	Target Neighborhood Hits	1094	Shared Neighborhood Hits	61
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 777)	NC score	0.079189 (rank : 548)
Query Neighborhood Hits	314	Target Neighborhood Hits	864	Shared Neighborhood Hits	51
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 778)	NC score	0.079060 (rank : 551)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RON_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.112371 (rank : 374)
Query Neighborhood Hits	314	Target Neighborhood Hits	842	Shared Neighborhood Hits	50
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.114200 (rank : 354)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	51
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.109597 (rank : 402)
Query Neighborhood Hits	314	Target Neighborhood Hits	1018	Shared Neighborhood Hits	50
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 782)	NC score	0.109947 (rank : 400)
Query Neighborhood Hits	314	Target Neighborhood Hits	1025	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.111168 (rank : 391)
Query Neighborhood Hits	314	Target Neighborhood Hits	1014	Shared Neighborhood Hits	50
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 784)	NC score	0.113565 (rank : 357)
Query Neighborhood Hits	314	Target Neighborhood Hits	1000	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 785)	NC score	0.120400 (rank : 328)
Query Neighborhood Hits	314	Target Neighborhood Hits	907	Shared Neighborhood Hits	52
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RUSC2_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.104574 (rank : 434)
Query Neighborhood Hits	314	Target Neighborhood Hits	205	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.088928 (rank : 501)
Query Neighborhood Hits	314	Target Neighborhood Hits	305	Shared Neighborhood Hits	69
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RYK_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.125153 (rank : 321)
Query Neighborhood Hits	314	Target Neighborhood Hits	701	Shared Neighborhood Hits	48
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 789)	NC score	0.124007 (rank : 324)
Query Neighborhood Hits	314	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SBK1_HUMAN
θ value	θ > 10 (rank : 790)	NC score	0.057424 (rank : 689)
Query Neighborhood Hits	314	Target Neighborhood Hits	828	Shared Neighborhood Hits	51
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 791)	NC score	0.058444 (rank : 671)
Query Neighborhood Hits	314	Target Neighborhood Hits	824	Shared Neighborhood Hits	51
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SH21A_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.300407 (rank : 163)
Query Neighborhood Hits	314	Target Neighborhood Hits	89	Shared Neighborhood Hits	83
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 793)	NC score	0.304328 (rank : 159)
Query Neighborhood Hits	314	Target Neighborhood Hits	89	Shared Neighborhood Hits	84
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH24A_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.239276 (rank : 218)
Query Neighborhood Hits	314	Target Neighborhood Hits	455	Shared Neighborhood Hits	100
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SHLB1_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.153544 (rank : 304)
Query Neighborhood Hits	314	Target Neighborhood Hits	96	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 796)	NC score	0.157479 (rank : 297)
Query Neighborhood Hits	314	Target Neighborhood Hits	101	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.149127 (rank : 306)
Query Neighborhood Hits	314	Target Neighborhood Hits	86	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 798)	NC score	0.154640 (rank : 303)
Query Neighborhood Hits	314	Target Neighborhood Hits	88	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLK_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.051397 (rank : 842)
Query Neighborhood Hits	314	Target Neighborhood Hits	1775	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.050243 (rank : 885)
Query Neighborhood Hits	314	Target Neighborhood Hits	1798	Shared Neighborhood Hits	66
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SN1L1_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.055940 (rank : 736)
Query Neighborhood Hits	314	Target Neighborhood Hits	911	Shared Neighborhood Hits	50
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.056933 (rank : 702)
Query Neighborhood Hits	314	Target Neighborhood Hits	895	Shared Neighborhood Hits	55
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.059627 (rank : 646)
Query Neighborhood Hits	314	Target Neighborhood Hits	964	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 804)	NC score	0.059174 (rank : 656)
Query Neighborhood Hits	314	Target Neighborhood Hits	944	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNRK_HUMAN
θ value	θ > 10 (rank : 805)	NC score	0.051298 (rank : 845)
Query Neighborhood Hits	314	Target Neighborhood Hits	855	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_MOUSE
θ value	θ > 10 (rank : 806)	NC score	0.051894 (rank : 831)
Query Neighborhood Hits	314	Target Neighborhood Hits	849	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

ST17B_HUMAN
θ value	θ > 10 (rank : 807)	NC score	0.050391 (rank : 881)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 808)	NC score	0.051060 (rank : 855)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK10_HUMAN
θ value	θ > 10 (rank : 809)	NC score	0.054178 (rank : 779)
Query Neighborhood Hits	314	Target Neighborhood Hits	1921	Shared Neighborhood Hits	79
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	θ > 10 (rank : 810)	NC score	0.053349 (rank : 797)
Query Neighborhood Hits	314	Target Neighborhood Hits	2132	Shared Neighborhood Hits	80
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.054215 (rank : 777)
Query Neighborhood Hits	314	Target Neighborhood Hits	831	Shared Neighborhood Hits	50
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK16_HUMAN
θ value	θ > 10 (rank : 812)	NC score	0.062168 (rank : 620)
Query Neighborhood Hits	314	Target Neighborhood Hits	824	Shared Neighborhood Hits	50
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 813)	NC score	0.063811 (rank : 602)
Query Neighborhood Hits	314	Target Neighborhood Hits	824	Shared Neighborhood Hits	51
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 814)	NC score	0.063248 (rank : 608)
Query Neighborhood Hits	314	Target Neighborhood Hits	853	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.063761 (rank : 604)
Query Neighborhood Hits	314	Target Neighborhood Hits	856	Shared Neighborhood Hits	50
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.062000 (rank : 621)
Query Neighborhood Hits	314	Target Neighborhood Hits	853	Shared Neighborhood Hits	50
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 817)	NC score	0.062351 (rank : 619)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.050960 (rank : 859)
Query Neighborhood Hits	314	Target Neighborhood Hits	879	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.050586 (rank : 874)
Query Neighborhood Hits	314	Target Neighborhood Hits	825	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK39_HUMAN
θ value	θ > 10 (rank : 820)	NC score	0.066522 (rank : 591)
Query Neighborhood Hits	314	Target Neighborhood Hits	882	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 821)	NC score	0.066499 (rank : 592)
Query Neighborhood Hits	314	Target Neighborhood Hits	915	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 822)	NC score	0.057218 (rank : 694)
Query Neighborhood Hits	314	Target Neighborhood Hits	861	Shared Neighborhood Hits	50
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 823)	NC score	0.057012 (rank : 700)
Query Neighborhood Hits	314	Target Neighborhood Hits	869	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.057002 (rank : 701)
Query Neighborhood Hits	314	Target Neighborhood Hits	870	Shared Neighborhood Hits	50
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 825)	NC score	0.057070 (rank : 698)
Query Neighborhood Hits	314	Target Neighborhood Hits	873	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 826)	NC score	0.052570 (rank : 813)
Query Neighborhood Hits	314	Target Neighborhood Hits	916	Shared Neighborhood Hits	52
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.050875 (rank : 861)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STS1_HUMAN
θ value	θ > 10 (rank : 828)	NC score	0.104915 (rank : 430)
Query Neighborhood Hits	314	Target Neighborhood Hits	106	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 829)	NC score	0.106486 (rank : 421)
Query Neighborhood Hits	314	Target Neighborhood Hits	104	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 830)	NC score	0.120237 (rank : 329)
Query Neighborhood Hits	314	Target Neighborhood Hits	108	Shared Neighborhood Hits	80
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

STYK1_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.125764 (rank : 319)
Query Neighborhood Hits	314	Target Neighborhood Hits	786	Shared Neighborhood Hits	50
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 832)	NC score	0.124803 (rank : 323)
Query Neighborhood Hits	314	Target Neighborhood Hits	779	Shared Neighborhood Hits	50
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.050604 (rank : 873)
Query Neighborhood Hits	314	Target Neighborhood Hits	162	Shared Neighborhood Hits	12
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

TAOK1_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.056682 (rank : 712)
Query Neighborhood Hits	314	Target Neighborhood Hits	1734	Shared Neighborhood Hits	68
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 835)	NC score	0.056576 (rank : 717)
Query Neighborhood Hits	314	Target Neighborhood Hits	1720	Shared Neighborhood Hits	67
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	θ > 10 (rank : 836)	NC score	0.060660 (rank : 627)
Query Neighborhood Hits	314	Target Neighborhood Hits	1172	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 837)	NC score	0.061710 (rank : 624)
Query Neighborhood Hits	314	Target Neighborhood Hits	1373	Shared Neighborhood Hits	66
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK3_HUMAN
θ value	θ > 10 (rank : 838)	NC score	0.055491 (rank : 746)
Query Neighborhood Hits	314	Target Neighborhood Hits	1494	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	θ > 10 (rank : 839)	NC score	0.055398 (rank : 749)
Query Neighborhood Hits	314	Target Neighborhood Hits	1458	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TBK1_HUMAN
θ value	θ > 10 (rank : 840)	NC score	0.053424 (rank : 794)
Query Neighborhood Hits	314	Target Neighborhood Hits	861	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 841)	NC score	0.052908 (rank : 802)
Query Neighborhood Hits	314	Target Neighborhood Hits	893	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TCGAP_HUMAN
θ value	θ > 10 (rank : 842)	NC score	0.140578 (rank : 310)
Query Neighborhood Hits	314	Target Neighborhood Hits	872	Shared Neighborhood Hits	129
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 843)	NC score	0.157359 (rank : 298)
Query Neighborhood Hits	314	Target Neighborhood Hits	409	Shared Neighborhood Hits	120
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TESK1_HUMAN
θ value	θ > 10 (rank : 844)	NC score	0.081581 (rank : 538)
Query Neighborhood Hits	314	Target Neighborhood Hits	864	Shared Neighborhood Hits	55
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 845)	NC score	0.081043 (rank : 541)
Query Neighborhood Hits	314	Target Neighborhood Hits	862	Shared Neighborhood Hits	52
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 846)	NC score	0.083800 (rank : 527)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	51
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 847)	NC score	0.082737 (rank : 529)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 848)	NC score	0.116016 (rank : 341)
Query Neighborhood Hits	314	Target Neighborhood Hits	1103	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 849)	NC score	0.113539 (rank : 359)
Query Neighborhood Hits	314	Target Neighborhood Hits	1333	Shared Neighborhood Hits	68
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.080239 (rank : 544)
Query Neighborhood Hits	314	Target Neighborhood Hits	755	Shared Neighborhood Hits	50
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 851)	NC score	0.080135 (rank : 546)
Query Neighborhood Hits	314	Target Neighborhood Hits	753	Shared Neighborhood Hits	50
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_HUMAN
θ value	θ > 10 (rank : 852)	NC score	0.059824 (rank : 638)
Query Neighborhood Hits	314	Target Neighborhood Hits	748	Shared Neighborhood Hits	50
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 853)	NC score	0.059846 (rank : 637)
Query Neighborhood Hits	314	Target Neighborhood Hits	748	Shared Neighborhood Hits	50
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TIAM1_HUMAN
θ value	θ > 10 (rank : 854)	NC score	0.110758 (rank : 393)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 855)	NC score	0.112466 (rank : 371)
Query Neighborhood Hits	314	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIE1_HUMAN
θ value	θ > 10 (rank : 856)	NC score	0.105529 (rank : 427)
Query Neighborhood Hits	314	Target Neighborhood Hits	1241	Shared Neighborhood Hits	51
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 857)	NC score	0.105130 (rank : 428)
Query Neighborhood Hits	314	Target Neighborhood Hits	1266	Shared Neighborhood Hits	52
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 858)	NC score	0.104502 (rank : 435)
Query Neighborhood Hits	314	Target Neighborhood Hits	1192	Shared Neighborhood Hits	53
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 859)	NC score	0.104359 (rank : 437)
Query Neighborhood Hits	314	Target Neighborhood Hits	1204	Shared Neighborhood Hits	53
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TLK2_HUMAN
θ value	θ > 10 (rank : 860)	NC score	0.052561 (rank : 814)
Query Neighborhood Hits	314	Target Neighborhood Hits	1044	Shared Neighborhood Hits	53
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 861)	NC score	0.052043 (rank : 828)
Query Neighborhood Hits	314	Target Neighborhood Hits	1088	Shared Neighborhood Hits	55
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TNI3K_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.084688 (rank : 523)
Query Neighborhood Hits	314	Target Neighborhood Hits	1084	Shared Neighborhood Hits	63
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.085094 (rank : 522)
Query Neighborhood Hits	314	Target Neighborhood Hits	1079	Shared Neighborhood Hits	63
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 864)	NC score	0.056676 (rank : 715)
Query Neighborhood Hits	314	Target Neighborhood Hits	1570	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TNK1_HUMAN
θ value	θ > 10 (rank : 865)	NC score	0.119668 (rank : 330)
Query Neighborhood Hits	314	Target Neighborhood Hits	815	Shared Neighborhood Hits	56
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 866)	NC score	0.119168 (rank : 331)
Query Neighborhood Hits	314	Target Neighborhood Hits	806	Shared Neighborhood Hits	57
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 867)	NC score	0.082162 (rank : 531)
Query Neighborhood Hits	314	Target Neighborhood Hits	605	Shared Neighborhood Hits	48
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 868)	NC score	0.082077 (rank : 533)
Query Neighborhood Hits	314	Target Neighborhood Hits	618	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TRIO_HUMAN
θ value	θ > 10 (rank : 869)	NC score	0.088276 (rank : 505)
Query Neighborhood Hits	314	Target Neighborhood Hits	1580	Shared Neighborhood Hits	100
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TSSK1_HUMAN
θ value	θ > 10 (rank : 870)	NC score	0.052411 (rank : 822)
Query Neighborhood Hits	314	Target Neighborhood Hits	840	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK1_MOUSE
θ value	θ > 10 (rank : 871)	NC score	0.056484 (rank : 721)
Query Neighborhood Hits	314	Target Neighborhood Hits	835	Shared Neighborhood Hits	50
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 872)	NC score	0.054215 (rank : 778)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 873)	NC score	0.052758 (rank : 806)
Query Neighborhood Hits	314	Target Neighborhood Hits	819	Shared Neighborhood Hits	50
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK4_HUMAN
θ value	θ > 10 (rank : 874)	NC score	0.058660 (rank : 667)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	50
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 875)	NC score	0.057617 (rank : 688)
Query Neighborhood Hits	314	Target Neighborhood Hits	840	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TTBK1_HUMAN
θ value	θ > 10 (rank : 876)	NC score	0.064747 (rank : 599)
Query Neighborhood Hits	314	Target Neighborhood Hits	1058	Shared Neighborhood Hits	53
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 877)	NC score	0.059128 (rank : 659)
Query Neighborhood Hits	314	Target Neighborhood Hits	822	Shared Neighborhood Hits	45
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 878)	NC score	0.059727 (rank : 642)
Query Neighborhood Hits	314	Target Neighborhood Hits	811	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TTK_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.053704 (rank : 789)
Query Neighborhood Hits	314	Target Neighborhood Hits	816	Shared Neighborhood Hits	50
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TYK2_HUMAN
θ value	θ > 10 (rank : 880)	NC score	0.099409 (rank : 455)
Query Neighborhood Hits	314	Target Neighborhood Hits	841	Shared Neighborhood Hits	50
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 881)	NC score	0.100758 (rank : 451)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 882)	NC score	0.109275 (rank : 404)
Query Neighborhood Hits	314	Target Neighborhood Hits	995	Shared Neighborhood Hits	50
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 883)	NC score	0.109702 (rank : 401)
Query Neighborhood Hits	314	Target Neighborhood Hits	1007	Shared Neighborhood Hits	51
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 884)	NC score	0.111561 (rank : 385)
Query Neighborhood Hits	314	Target Neighborhood Hits	981	Shared Neighborhood Hits	51
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 885)	NC score	0.111536 (rank : 386)
Query Neighborhood Hits	314	Target Neighborhood Hits	988	Shared Neighborhood Hits	53
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

UHMK1_MOUSE
θ value	θ > 10 (rank : 886)	NC score	0.050533 (rank : 876)
Query Neighborhood Hits	314	Target Neighborhood Hits	809	Shared Neighborhood Hits	47
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ULK1_HUMAN
θ value	θ > 10 (rank : 887)	NC score	0.058435 (rank : 672)
Query Neighborhood Hits	314	Target Neighborhood Hits	1121	Shared Neighborhood Hits	59
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 888)	NC score	0.059690 (rank : 643)
Query Neighborhood Hits	314	Target Neighborhood Hits	1214	Shared Neighborhood Hits	73
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.057865 (rank : 685)
Query Neighborhood Hits	314	Target Neighborhood Hits	979	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 890)	NC score	0.058341 (rank : 675)
Query Neighborhood Hits	314	Target Neighborhood Hits	943	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.057089 (rank : 697)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 892)	NC score	0.055471 (rank : 747)
Query Neighborhood Hits	314	Target Neighborhood Hits	872	Shared Neighborhood Hits	50
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

USH1C_MOUSE
θ value	θ > 10 (rank : 893)	NC score	0.050857 (rank : 862)
Query Neighborhood Hits	314	Target Neighborhood Hits	557	Shared Neighborhood Hits	37
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

VGFR1_HUMAN
θ value	θ > 10 (rank : 894)	NC score	0.097662 (rank : 460)
Query Neighborhood Hits	314	Target Neighborhood Hits	1109	Shared Neighborhood Hits	50
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 895)	NC score	0.097155 (rank : 462)
Query Neighborhood Hits	314	Target Neighborhood Hits	1118	Shared Neighborhood Hits	50
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 896)	NC score	0.099409 (rank : 454)
Query Neighborhood Hits	314	Target Neighborhood Hits	1103	Shared Neighborhood Hits	50
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 897)	NC score	0.099583 (rank : 453)
Query Neighborhood Hits	314	Target Neighborhood Hits	1089	Shared Neighborhood Hits	50
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 898)	NC score	0.102746 (rank : 444)
Query Neighborhood Hits	314	Target Neighborhood Hits	1037	Shared Neighborhood Hits	50
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 899)	NC score	0.102589 (rank : 447)
Query Neighborhood Hits	314	Target Neighborhood Hits	1056	Shared Neighborhood Hits	50
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

WNK1_HUMAN
θ value	θ > 10 (rank : 900)	NC score	0.058560 (rank : 670)
Query Neighborhood Hits	314	Target Neighborhood Hits	1158	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 901)	NC score	0.058932 (rank : 661)
Query Neighborhood Hits	314	Target Neighborhood Hits	1179	Shared Neighborhood Hits	59
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.062416 (rank : 617)
Query Neighborhood Hits	314	Target Neighborhood Hits	1407	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK3_HUMAN
θ value	θ > 10 (rank : 903)	NC score	0.058609 (rank : 668)
Query Neighborhood Hits	314	Target Neighborhood Hits	948	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

YSK4_HUMAN
θ value	θ > 10 (rank : 904)	NC score	0.063764 (rank : 603)
Query Neighborhood Hits	314	Target Neighborhood Hits	921	Shared Neighborhood Hits	50
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZO1_HUMAN
θ value	θ > 10 (rank : 905)	NC score	0.069283 (rank : 583)
Query Neighborhood Hits	314	Target Neighborhood Hits	474	Shared Neighborhood Hits	45
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	θ > 10 (rank : 906)	NC score	0.067791 (rank : 589)
Query Neighborhood Hits	314	Target Neighborhood Hits	453	Shared Neighborhood Hits	37
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO2_HUMAN
θ value	θ > 10 (rank : 907)	NC score	0.071470 (rank : 579)
Query Neighborhood Hits	314	Target Neighborhood Hits	289	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	θ > 10 (rank : 908)	NC score	0.074527 (rank : 565)
Query Neighborhood Hits	314	Target Neighborhood Hits	296	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO3_HUMAN
θ value	θ > 10 (rank : 909)	NC score	0.081710 (rank : 536)
Query Neighborhood Hits	314	Target Neighborhood Hits	219	Shared Neighborhood Hits	27
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.077996 (rank : 555)
Query Neighborhood Hits	314	Target Neighborhood Hits	224	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

Hits sorted by NC score

CRK_MOUSE
NC score	0.999962 (rank : 1)	θ value	4.11978e-162 (rank : 1)
Query Neighborhood Hits	314	Target Neighborhood Hits	314	Shared Neighborhood Hits	314
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.996582 (rank : 2)	θ value	2.49938e-159 (rank : 2)
Query Neighborhood Hits	314	Target Neighborhood Hits	308	Shared Neighborhood Hits	304
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
NC score	0.961763 (rank : 3)	θ value	2.38316e-93 (rank : 3)
Query Neighborhood Hits	314	Target Neighborhood Hits	313	Shared Neighborhood Hits	283
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.959286 (rank : 4)	θ value	6.93392e-93 (rank : 4)
Query Neighborhood Hits	314	Target Neighborhood Hits	307	Shared Neighborhood Hits	284
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

GRAP_HUMAN
NC score	0.793671 (rank : 5)	θ value	2.5182e-18 (rank : 5)
Query Neighborhood Hits	314	Target Neighborhood Hits	307	Shared Neighborhood Hits	275
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRB2_MOUSE
NC score	0.792510 (rank : 6)	θ value	2.60593e-15 (rank : 8)
Query Neighborhood Hits	314	Target Neighborhood Hits	312	Shared Neighborhood Hits	274
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.792479 (rank : 7)	θ value	2.60593e-15 (rank : 7)
Query Neighborhood Hits	314	Target Neighborhood Hits	310	Shared Neighborhood Hits	272
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRAP_MOUSE
NC score	0.786682 (rank : 8)	θ value	1.99529e-15 (rank : 6)
Query Neighborhood Hits	314	Target Neighborhood Hits	309	Shared Neighborhood Hits	274
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK1_HUMAN
NC score	0.727916 (rank : 9)	θ value	8.40245e-06 (rank : 38)
Query Neighborhood Hits	314	Target Neighborhood Hits	312	Shared Neighborhood Hits	272
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
NC score	0.719815 (rank : 10)	θ value	3.19293e-05 (rank : 54)
Query Neighborhood Hits	314	Target Neighborhood Hits	310	Shared Neighborhood Hits	271
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP2_MOUSE
NC score	0.711882 (rank : 11)	θ value	5.44631e-05 (rank : 61)
Query Neighborhood Hits	314	Target Neighborhood Hits	297	Shared Neighborhood Hits	266
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.710952 (rank : 12)	θ value	4.1701e-05 (rank : 58)
Query Neighborhood Hits	314	Target Neighborhood Hits	304	Shared Neighborhood Hits	268
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CD2AP_HUMAN
NC score	0.583941 (rank : 13)	θ value	1.53129e-07 (rank : 17)
Query Neighborhood Hits	314	Target Neighborhood Hits	315	Shared Neighborhood Hits	193
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

VAV_HUMAN
NC score	0.578992 (rank : 14)	θ value	4.76016e-09 (rank : 12)
Query Neighborhood Hits	314	Target Neighborhood Hits	452	Shared Neighborhood Hits	250
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PLCG1_MOUSE
NC score	0.578368 (rank : 15)	θ value	9.59137e-10 (rank : 11)
Query Neighborhood Hits	314	Target Neighborhood Hits	314	Shared Neighborhood Hits	237
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NPHP1_MOUSE
NC score	0.575800 (rank : 16)	θ value	6.21693e-09 (rank : 13)
Query Neighborhood Hits	314	Target Neighborhood Hits	267	Shared Neighborhood Hits	191
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PLCG1_HUMAN
NC score	0.571124 (rank : 17)	θ value	7.34386e-10 (rank : 10)
Query Neighborhood Hits	314	Target Neighborhood Hits	293	Shared Neighborhood Hits	231
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CD2AP_MOUSE
NC score	0.569511 (rank : 18)	θ value	2.21117e-06 (rank : 25)
Query Neighborhood Hits	314	Target Neighborhood Hits	336	Shared Neighborhood Hits	194
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

VAV_MOUSE
NC score	0.560973 (rank : 19)	θ value	4.0297e-08 (rank : 14)
Query Neighborhood Hits	314	Target Neighborhood Hits	430	Shared Neighborhood Hits	245
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV3_HUMAN
NC score	0.559038 (rank : 20)	θ value	6.87365e-08 (rank : 15)
Query Neighborhood Hits	314	Target Neighborhood Hits	398	Shared Neighborhood Hits	244
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.556514 (rank : 21)	θ value	6.87365e-08 (rank : 16)
Query Neighborhood Hits	314	Target Neighborhood Hits	404	Shared Neighborhood Hits	242
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SH3K1_HUMAN
NC score	0.551431 (rank : 22)	θ value	6.43352e-06 (rank : 36)
Query Neighborhood Hits	314	Target Neighborhood Hits	341	Shared Neighborhood Hits	191
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

PLCG2_HUMAN
NC score	0.551055 (rank : 23)	θ value	0.000121331 (rank : 73)
Query Neighborhood Hits	314	Target Neighborhood Hits	280	Shared Neighborhood Hits	225
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SH3K1_MOUSE
NC score	0.546067 (rank : 24)	θ value	5.44631e-05 (rank : 63)
Query Neighborhood Hits	314	Target Neighborhood Hits	332	Shared Neighborhood Hits	193
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF2_HUMAN
NC score	0.541778 (rank : 25)	θ value	0.000461057 (rank : 103)
Query Neighborhood Hits	314	Target Neighborhood Hits	229	Shared Neighborhood Hits	170
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VAV2_HUMAN
NC score	0.537824 (rank : 26)	θ value	1.09739e-05 (rank : 40)
Query Neighborhood Hits	314	Target Neighborhood Hits	453	Shared Neighborhood Hits	251
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.532887 (rank : 27)	θ value	0.000121331 (rank : 76)
Query Neighborhood Hits	314	Target Neighborhood Hits	456	Shared Neighborhood Hits	248
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

SRBS1_HUMAN
NC score	0.531429 (rank : 28)	θ value	2.21117e-06 (rank : 31)
Query Neighborhood Hits	314	Target Neighborhood Hits	396	Shared Neighborhood Hits	192
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.530464 (rank : 29)	θ value	0.00134147 (rank : 137)
Query Neighborhood Hits	314	Target Neighborhood Hits	270	Shared Neighborhood Hits	188
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.527649 (rank : 30)	θ value	0.00102713 (rank : 131)
Query Neighborhood Hits	314	Target Neighborhood Hits	286	Shared Neighborhood Hits	189
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NPHP1_HUMAN
NC score	0.527125 (rank : 31)	θ value	2.61198e-07 (rank : 18)
Query Neighborhood Hits	314	Target Neighborhood Hits	288	Shared Neighborhood Hits	168
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SRBS1_MOUSE
NC score	0.523118 (rank : 32)	θ value	3.19293e-05 (rank : 57)
Query Neighborhood Hits	314	Target Neighborhood Hits	409	Shared Neighborhood Hits	189
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM1_MOUSE
NC score	0.521524 (rank : 33)	θ value	5.44631e-05 (rank : 65)
Query Neighborhood Hits	314	Target Neighborhood Hits	273	Shared Neighborhood Hits	199
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.518359 (rank : 34)	θ value	5.44631e-05 (rank : 64)
Query Neighborhood Hits	314	Target Neighborhood Hits	271	Shared Neighborhood Hits	202
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
NC score	0.515237 (rank : 35)	θ value	1.87187e-05 (rank : 48)
Query Neighborhood Hits	314	Target Neighborhood Hits	285	Shared Neighborhood Hits	195
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.503309 (rank : 36)	θ value	9.29e-05 (rank : 70)
Query Neighborhood Hits	314	Target Neighborhood Hits	288	Shared Neighborhood Hits	191
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

PPIP1_HUMAN
NC score	0.496656 (rank : 37)	θ value	5.44631e-05 (rank : 62)
Query Neighborhood Hits	314	Target Neighborhood Hits	389	Shared Neighborhood Hits	197
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
NC score	0.495431 (rank : 38)	θ value	7.1131e-05 (rank : 67)
Query Neighborhood Hits	314	Target Neighborhood Hits	377	Shared Neighborhood Hits	196
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

DNMBP_HUMAN
NC score	0.494605 (rank : 39)	θ value	8.67504e-11 (rank : 9)
Query Neighborhood Hits	314	Target Neighborhood Hits	413	Shared Neighborhood Hits	193
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
NC score	0.475437 (rank : 40)	θ value	3.41135e-07 (rank : 19)
Query Neighborhood Hits	314	Target Neighborhood Hits	435	Shared Neighborhood Hits	194
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PACN2_MOUSE
NC score	0.472069 (rank : 41)	θ value	7.1131e-05 (rank : 66)
Query Neighborhood Hits	314	Target Neighborhood Hits	382	Shared Neighborhood Hits	186
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.470737 (rank : 42)	θ value	0.000158464 (rank : 82)
Query Neighborhood Hits	314	Target Neighborhood Hits	339	Shared Neighborhood Hits	180
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SHC3_MOUSE
NC score	0.470696 (rank : 43)	θ value	1.43324e-05 (rank : 45)
Query Neighborhood Hits	314	Target Neighborhood Hits	151	Shared Neighborhood Hits	123
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SH3G3_MOUSE
NC score	0.469546 (rank : 44)	θ value	0.000786445 (rank : 122)
Query Neighborhood Hits	314	Target Neighborhood Hits	236	Shared Neighborhood Hits	188
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

PACN1_HUMAN
NC score	0.468976 (rank : 45)	θ value	0.00020696 (rank : 88)
Query Neighborhood Hits	314	Target Neighborhood Hits	320	Shared Neighborhood Hits	179
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.467732 (rank : 46)	θ value	0.00020696 (rank : 89)
Query Neighborhood Hits	314	Target Neighborhood Hits	283	Shared Neighborhood Hits	177
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ARHG7_MOUSE
NC score	0.466350 (rank : 47)	θ value	2.44474e-05 (rank : 49)
Query Neighborhood Hits	314	Target Neighborhood Hits	396	Shared Neighborhood Hits	200
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

NCF1_HUMAN
NC score	0.465369 (rank : 48)	θ value	0.00665767 (rank : 166)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	162
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

STAC_HUMAN
NC score	0.465294 (rank : 49)	θ value	0.0961366 (rank : 231)
Query Neighborhood Hits	314	Target Neighborhood Hits	276	Shared Neighborhood Hits	187
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SHC1_MOUSE
NC score	0.460636 (rank : 50)	θ value	2.21117e-06 (rank : 30)
Query Neighborhood Hits	314	Target Neighborhood Hits	180	Shared Neighborhood Hits	126
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SH3G2_HUMAN
NC score	0.459007 (rank : 51)	θ value	0.000602161 (rank : 111)
Query Neighborhood Hits	314	Target Neighborhood Hits	324	Shared Neighborhood Hits	188
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SHC1_HUMAN
NC score	0.458176 (rank : 52)	θ value	2.21117e-06 (rank : 29)
Query Neighborhood Hits	314	Target Neighborhood Hits	170	Shared Neighborhood Hits	125
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

NCF4_MOUSE
NC score	0.456993 (rank : 53)	θ value	9.29e-05 (rank : 69)
Query Neighborhood Hits	314	Target Neighborhood Hits	177	Shared Neighborhood Hits	141
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_MOUSE
NC score	0.456413 (rank : 54)	θ value	0.21417 (rank : 253)
Query Neighborhood Hits	314	Target Neighborhood Hits	268	Shared Neighborhood Hits	184
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_HUMAN
NC score	0.454986 (rank : 55)	θ value	0.00035302 (rank : 96)
Query Neighborhood Hits	314	Target Neighborhood Hits	347	Shared Neighborhood Hits	200
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

SHC3_HUMAN
NC score	0.454972 (rank : 56)	θ value	1.87187e-05 (rank : 47)
Query Neighborhood Hits	314	Target Neighborhood Hits	155	Shared Neighborhood Hits	116
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

DAPP1_MOUSE
NC score	0.453915 (rank : 57)	θ value	0.000786445 (rank : 113)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	137
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SLAP2_HUMAN
NC score	0.453387 (rank : 58)	θ value	0.0563607 (rank : 221)
Query Neighborhood Hits	314	Target Neighborhood Hits	139	Shared Neighborhood Hits	130
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

NCF1_MOUSE
NC score	0.452108 (rank : 59)	θ value	0.0113563 (rank : 178)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	166
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SH3G2_MOUSE
NC score	0.450736 (rank : 60)	θ value	0.00134147 (rank : 134)
Query Neighborhood Hits	314	Target Neighborhood Hits	319	Shared Neighborhood Hits	186
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
NC score	0.450504 (rank : 61)	θ value	0.00102713 (rank : 129)
Query Neighborhood Hits	314	Target Neighborhood Hits	222	Shared Neighborhood Hits	178
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

DAPP1_HUMAN
NC score	0.450078 (rank : 62)	θ value	0.00869519 (rank : 170)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

HCLS1_MOUSE
NC score	0.446723 (rank : 63)	θ value	0.0961366 (rank : 228)
Query Neighborhood Hits	314	Target Neighborhood Hits	329	Shared Neighborhood Hits	164
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SLAP2_MOUSE
NC score	0.444926 (rank : 64)	θ value	0.163984 (rank : 242)
Query Neighborhood Hits	314	Target Neighborhood Hits	136	Shared Neighborhood Hits	123
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SHC2_MOUSE
NC score	0.444148 (rank : 65)	θ value	0.00020696 (rank : 90)
Query Neighborhood Hits	314	Target Neighborhood Hits	144	Shared Neighborhood Hits	122
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

GRB14_MOUSE
NC score	0.443836 (rank : 66)	θ value	2.21117e-06 (rank : 27)
Query Neighborhood Hits	314	Target Neighborhood Hits	149	Shared Neighborhood Hits	117
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

PACN3_MOUSE
NC score	0.443665 (rank : 67)	θ value	0.00102713 (rank : 128)
Query Neighborhood Hits	314	Target Neighborhood Hits	380	Shared Neighborhood Hits	170
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

HCLS1_HUMAN
NC score	0.442759 (rank : 68)	θ value	0.21417 (rank : 248)
Query Neighborhood Hits	314	Target Neighborhood Hits	358	Shared Neighborhood Hits	165
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PACN3_HUMAN
NC score	0.440681 (rank : 69)	θ value	0.00102713 (rank : 127)
Query Neighborhood Hits	314	Target Neighborhood Hits	385	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

SHC2_HUMAN
NC score	0.440238 (rank : 70)	θ value	0.000461057 (rank : 107)
Query Neighborhood Hits	314	Target Neighborhood Hits	170	Shared Neighborhood Hits	121
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHE_MOUSE
NC score	0.438030 (rank : 71)	θ value	0.0252991 (rank : 199)
Query Neighborhood Hits	314	Target Neighborhood Hits	169	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SH3G1_MOUSE
NC score	0.437298 (rank : 72)	θ value	0.0148317 (rank : 185)
Query Neighborhood Hits	314	Target Neighborhood Hits	291	Shared Neighborhood Hits	185
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ABI2_MOUSE
NC score	0.435147 (rank : 73)	θ value	0.21417 (rank : 244)
Query Neighborhood Hits	314	Target Neighborhood Hits	266	Shared Neighborhood Hits	183
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SH3G1_HUMAN
NC score	0.434496 (rank : 74)	θ value	0.00665767 (rank : 167)
Query Neighborhood Hits	314	Target Neighborhood Hits	307	Shared Neighborhood Hits	179
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

APS_HUMAN
NC score	0.434207 (rank : 75)	θ value	0.000461057 (rank : 100)
Query Neighborhood Hits	314	Target Neighborhood Hits	162	Shared Neighborhood Hits	107
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

RASA1_HUMAN
NC score	0.432800 (rank : 76)	θ value	1.43324e-05 (rank : 44)
Query Neighborhood Hits	314	Target Neighborhood Hits	258	Shared Neighborhood Hits	137
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

ABI2_HUMAN
NC score	0.432372 (rank : 77)	θ value	0.21417 (rank : 243)
Query Neighborhood Hits	314	Target Neighborhood Hits	350	Shared Neighborhood Hits	185
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SRC8_HUMAN
NC score	0.431505 (rank : 78)	θ value	0.62314 (rank : 268)
Query Neighborhood Hits	314	Target Neighborhood Hits	269	Shared Neighborhood Hits	171
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SHB_MOUSE
NC score	0.431326 (rank : 79)	θ value	0.000786445 (rank : 123)
Query Neighborhood Hits	314	Target Neighborhood Hits	137	Shared Neighborhood Hits	125
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

GRB14_HUMAN
NC score	0.429157 (rank : 80)	θ value	1.43324e-05 (rank : 41)
Query Neighborhood Hits	314	Target Neighborhood Hits	137	Shared Neighborhood Hits	113
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ARHG6_MOUSE
NC score	0.427507 (rank : 81)	θ value	0.00390308 (rank : 151)
Query Neighborhood Hits	314	Target Neighborhood Hits	394	Shared Neighborhood Hits	188
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SHD_MOUSE
NC score	0.426934 (rank : 82)	θ value	0.00869519 (rank : 173)
Query Neighborhood Hits	314	Target Neighborhood Hits	137	Shared Neighborhood Hits	122
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

LNK_MOUSE
NC score	0.425769 (rank : 83)	θ value	0.00175202 (rank : 138)
Query Neighborhood Hits	314	Target Neighborhood Hits	132	Shared Neighborhood Hits	107
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SRC8_MOUSE
NC score	0.425614 (rank : 84)	θ value	0.62314 (rank : 269)
Query Neighborhood Hits	314	Target Neighborhood Hits	292	Shared Neighborhood Hits	172
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SHE_HUMAN
NC score	0.425375 (rank : 85)	θ value	0.0736092 (rank : 224)
Query Neighborhood Hits	314	Target Neighborhood Hits	164	Shared Neighborhood Hits	124
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHB_HUMAN
NC score	0.424557 (rank : 86)	θ value	0.00175202 (rank : 141)
Query Neighborhood Hits	314	Target Neighborhood Hits	141	Shared Neighborhood Hits	124
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

ARHG6_HUMAN
NC score	0.422678 (rank : 87)	θ value	0.0193708 (rank : 193)
Query Neighborhood Hits	314	Target Neighborhood Hits	376	Shared Neighborhood Hits	184
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

OSTF1_HUMAN
NC score	0.422390 (rank : 88)	θ value	0.000461057 (rank : 104)
Query Neighborhood Hits	314	Target Neighborhood Hits	466	Shared Neighborhood Hits	202
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

LNK_HUMAN
NC score	0.422120 (rank : 89)	θ value	0.00390308 (rank : 153)
Query Neighborhood Hits	314	Target Neighborhood Hits	151	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

NCF4_HUMAN
NC score	0.421023 (rank : 90)	θ value	0.0330416 (rank : 207)
Query Neighborhood Hits	314	Target Neighborhood Hits	161	Shared Neighborhood Hits	128
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC3_MOUSE
NC score	0.418520 (rank : 91)	θ value	0.0148317 (rank : 191)
Query Neighborhood Hits	314	Target Neighborhood Hits	232	Shared Neighborhood Hits	154
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SH2D3_MOUSE
NC score	0.418256 (rank : 92)	θ value	6.43352e-06 (rank : 35)
Query Neighborhood Hits	314	Target Neighborhood Hits	174	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

GRB7_MOUSE
NC score	0.418118 (rank : 93)	θ value	1.43324e-05 (rank : 42)
Query Neighborhood Hits	314	Target Neighborhood Hits	157	Shared Neighborhood Hits	116
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

STAC3_HUMAN
NC score	0.416897 (rank : 94)	θ value	0.0148317 (rank : 190)
Query Neighborhood Hits	314	Target Neighborhood Hits	228	Shared Neighborhood Hits	153
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

BCAR3_HUMAN
NC score	0.414451 (rank : 95)	θ value	4.92598e-06 (rank : 33)
Query Neighborhood Hits	314	Target Neighborhood Hits	129	Shared Neighborhood Hits	93
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

P85A_MOUSE
NC score	0.413972 (rank : 96)	θ value	0.000786445 (rank : 119)
Query Neighborhood Hits	314	Target Neighborhood Hits	435	Shared Neighborhood Hits	178
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SH2D3_HUMAN
NC score	0.410875 (rank : 97)	θ value	2.44474e-05 (rank : 52)
Query Neighborhood Hits	314	Target Neighborhood Hits	188	Shared Neighborhood Hits	99
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

BCAR3_MOUSE
NC score	0.408315 (rank : 98)	θ value	6.43352e-06 (rank : 34)
Query Neighborhood Hits	314	Target Neighborhood Hits	127	Shared Neighborhood Hits	91
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

SHD_HUMAN
NC score	0.406423 (rank : 99)	θ value	0.0148317 (rank : 186)
Query Neighborhood Hits	314	Target Neighborhood Hits	204	Shared Neighborhood Hits	120
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

P85A_HUMAN
NC score	0.403484 (rank : 100)	θ value	0.000461057 (rank : 105)
Query Neighborhood Hits	314	Target Neighborhood Hits	479	Shared Neighborhood Hits	171
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

OSTF1_MOUSE
NC score	0.401681 (rank : 101)	θ value	0.00175202 (rank : 139)
Query Neighborhood Hits	314	Target Neighborhood Hits	467	Shared Neighborhood Hits	203
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DBNL_HUMAN
NC score	0.400975 (rank : 102)	θ value	0.0193708 (rank : 194)
Query Neighborhood Hits	314	Target Neighborhood Hits	244	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SLAP1_MOUSE
NC score	0.400518 (rank : 103)	θ value	0.813845 (rank : 273)
Query Neighborhood Hits	314	Target Neighborhood Hits	117	Shared Neighborhood Hits	107
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

GRB7_HUMAN
NC score	0.400309 (rank : 104)	θ value	3.19293e-05 (rank : 53)
Query Neighborhood Hits	314	Target Neighborhood Hits	156	Shared Neighborhood Hits	114
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SH23A_HUMAN
NC score	0.399880 (rank : 105)	θ value	8.40245e-06 (rank : 39)
Query Neighborhood Hits	314	Target Neighborhood Hits	149	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SLAP1_HUMAN
NC score	0.399515 (rank : 106)	θ value	0.813845 (rank : 272)
Query Neighborhood Hits	314	Target Neighborhood Hits	113	Shared Neighborhood Hits	107
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

P85B_HUMAN
NC score	0.399397 (rank : 107)	θ value	0.000786445 (rank : 120)
Query Neighborhood Hits	314	Target Neighborhood Hits	543	Shared Neighborhood Hits	151
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
NC score	0.398548 (rank : 108)	θ value	0.000786445 (rank : 121)
Query Neighborhood Hits	314	Target Neighborhood Hits	519	Shared Neighborhood Hits	149
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DBNL_MOUSE
NC score	0.397290 (rank : 109)	θ value	0.0193708 (rank : 195)
Query Neighborhood Hits	314	Target Neighborhood Hits	306	Shared Neighborhood Hits	150
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ABI1_MOUSE
NC score	0.396319 (rank : 110)	θ value	1.38821 (rank : 278)
Query Neighborhood Hits	314	Target Neighborhood Hits	246	Shared Neighborhood Hits	171
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

HSH2D_HUMAN
NC score	0.395388 (rank : 111)	θ value	0.0431538 (rank : 211)
Query Neighborhood Hits	314	Target Neighborhood Hits	159	Shared Neighborhood Hits	121
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

P55G_HUMAN
NC score	0.390462 (rank : 112)	θ value	0.000786445 (rank : 118)
Query Neighborhood Hits	314	Target Neighborhood Hits	451	Shared Neighborhood Hits	128
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
NC score	0.390360 (rank : 113)	θ value	0.000121331 (rank : 72)
Query Neighborhood Hits	314	Target Neighborhood Hits	401	Shared Neighborhood Hits	124
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SH21B_MOUSE
NC score	0.380492 (rank : 114)	θ value	0.47712 (rank : 265)
Query Neighborhood Hits	314	Target Neighborhood Hits	101	Shared Neighborhood Hits	92
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_HUMAN
NC score	0.373478 (rank : 115)	θ value	1.81305 (rank : 283)
Query Neighborhood Hits	314	Target Neighborhood Hits	101	Shared Neighborhood Hits	94
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

APS_MOUSE
NC score	0.372841 (rank : 116)	θ value	0.00665767 (rank : 161)
Query Neighborhood Hits	314	Target Neighborhood Hits	134	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ABI1_HUMAN
NC score	0.372801 (rank : 117)	θ value	5.27518 (rank : 293)
Query Neighborhood Hits	314	Target Neighborhood Hits	257	Shared Neighborhood Hits	170
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ITSN2_HUMAN
NC score	0.372285 (rank : 118)	θ value	0.00020696 (rank : 87)
Query Neighborhood Hits	314	Target Neighborhood Hits	1173	Shared Neighborhood Hits	225
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

AHI1_HUMAN
NC score	0.369160 (rank : 119)	θ value	0.00020696 (rank : 85)
Query Neighborhood Hits	314	Target Neighborhood Hits	537	Shared Neighborhood Hits	189
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

LASP1_HUMAN
NC score	0.368448 (rank : 120)	θ value	0.0431538 (rank : 212)
Query Neighborhood Hits	314	Target Neighborhood Hits	293	Shared Neighborhood Hits	151
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

GRB10_HUMAN
NC score	0.366795 (rank : 121)	θ value	0.000786445 (rank : 115)
Query Neighborhood Hits	314	Target Neighborhood Hits	147	Shared Neighborhood Hits	112
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
NC score	0.366135 (rank : 122)	θ value	0.000786445 (rank : 116)
Query Neighborhood Hits	314	Target Neighborhood Hits	156	Shared Neighborhood Hits	111
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

AHI1_MOUSE
NC score	0.364912 (rank : 123)	θ value	0.00102713 (rank : 124)
Query Neighborhood Hits	314	Target Neighborhood Hits	496	Shared Neighborhood Hits	189
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

LASP1_MOUSE
NC score	0.364326 (rank : 124)	θ value	0.0563607 (rank : 219)
Query Neighborhood Hits	314	Target Neighborhood Hits	297	Shared Neighborhood Hits	150
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ITSN2_MOUSE
NC score	0.355410 (rank : 125)	θ value	0.000158464 (rank : 80)
Query Neighborhood Hits	314	Target Neighborhood Hits	1371	Shared Neighborhood Hits	221
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_MOUSE
NC score	0.355173 (rank : 126)	θ value	8.40245e-06 (rank : 37)
Query Neighborhood Hits	314	Target Neighborhood Hits	1669	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ES8L3_MOUSE
NC score	0.354841 (rank : 127)	θ value	0.0330416 (rank : 205)
Query Neighborhood Hits	314	Target Neighborhood Hits	168	Shared Neighborhood Hits	139
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ITSN1_HUMAN
NC score	0.352608 (rank : 128)	θ value	1.43324e-05 (rank : 43)
Query Neighborhood Hits	314	Target Neighborhood Hits	1757	Shared Neighborhood Hits	230
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NEBL_HUMAN
NC score	0.346314 (rank : 129)	θ value	0.0330416 (rank : 208)
Query Neighborhood Hits	314	Target Neighborhood Hits	457	Shared Neighborhood Hits	155
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SOCS7_MOUSE
NC score	0.344144 (rank : 130)	θ value	0.00102713 (rank : 130)
Query Neighborhood Hits	314	Target Neighborhood Hits	154	Shared Neighborhood Hits	93
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

ABI3_HUMAN
NC score	0.341671 (rank : 131)	θ value	8.99809 (rank : 308)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	136
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CT032_HUMAN
NC score	0.339348 (rank : 132)	θ value	0.21417 (rank : 247)
Query Neighborhood Hits	314	Target Neighborhood Hits	235	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

SOCS2_MOUSE
NC score	0.335989 (rank : 133)	θ value	0.00509761 (rank : 160)
Query Neighborhood Hits	314	Target Neighborhood Hits	94	Shared Neighborhood Hits	84
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

ABI3_MOUSE
NC score	0.335776 (rank : 134)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	137
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ES8L2_HUMAN
NC score	0.329989 (rank : 135)	θ value	0.00298849 (rank : 148)
Query Neighborhood Hits	314	Target Neighborhood Hits	193	Shared Neighborhood Hits	130
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SOCS6_MOUSE
NC score	0.329864 (rank : 136)	θ value	0.0252991 (rank : 203)
Query Neighborhood Hits	314	Target Neighborhood Hits	146	Shared Neighborhood Hits	97
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

BCAR1_MOUSE
NC score	0.329808 (rank : 137)	θ value	0.0563607 (rank : 216)
Query Neighborhood Hits	314	Target Neighborhood Hits	438	Shared Neighborhood Hits	173
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ES8L3_HUMAN
NC score	0.328701 (rank : 138)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	314	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EFS_MOUSE
NC score	0.328615 (rank : 139)	θ value	0.47712 (rank : 264)
Query Neighborhood Hits	314	Target Neighborhood Hits	389	Shared Neighborhood Hits	162
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SOCS2_HUMAN
NC score	0.328179 (rank : 140)	θ value	0.00509761 (rank : 159)
Query Neighborhood Hits	314	Target Neighborhood Hits	104	Shared Neighborhood Hits	84
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SNX18_MOUSE
NC score	0.327305 (rank : 141)	θ value	0.000121331 (rank : 74)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SOCS6_HUMAN
NC score	0.326691 (rank : 142)	θ value	0.0252991 (rank : 202)
Query Neighborhood Hits	314	Target Neighborhood Hits	126	Shared Neighborhood Hits	95
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

ARHG4_HUMAN
NC score	0.326533 (rank : 143)	θ value	0.0193708 (rank : 192)
Query Neighborhood Hits	314	Target Neighborhood Hits	242	Shared Neighborhood Hits	165
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ES8L2_MOUSE
NC score	0.319498 (rank : 144)	θ value	0.0961366 (rank : 227)
Query Neighborhood Hits	314	Target Neighborhood Hits	169	Shared Neighborhood Hits	126
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

HSH2D_MOUSE
NC score	0.317678 (rank : 145)	θ value	0.21417 (rank : 249)
Query Neighborhood Hits	314	Target Neighborhood Hits	124	Shared Neighborhood Hits	102
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

CASL_MOUSE
NC score	0.316602 (rank : 146)	θ value	0.00665767 (rank : 163)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	150
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

SNX18_HUMAN
NC score	0.315921 (rank : 147)	θ value	0.000461057 (rank : 109)
Query Neighborhood Hits	314	Target Neighborhood Hits	207	Shared Neighborhood Hits	129
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

RHG04_HUMAN
NC score	0.315539 (rank : 148)	θ value	2.21117e-06 (rank : 28)
Query Neighborhood Hits	314	Target Neighborhood Hits	307	Shared Neighborhood Hits	166
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

EPS8_HUMAN
NC score	0.315364 (rank : 149)	θ value	0.000270298 (rank : 92)
Query Neighborhood Hits	314	Target Neighborhood Hits	151	Shared Neighborhood Hits	111
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

BCAR1_HUMAN
NC score	0.315262 (rank : 150)	θ value	0.279714 (rank : 254)
Query Neighborhood Hits	314	Target Neighborhood Hits	554	Shared Neighborhood Hits	175
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_HUMAN
NC score	0.314914 (rank : 151)	θ value	0.00665767 (rank : 162)
Query Neighborhood Hits	314	Target Neighborhood Hits	259	Shared Neighborhood Hits	150
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PEX13_HUMAN
NC score	0.314190 (rank : 152)	θ value	0.365318 (rank : 262)
Query Neighborhood Hits	314	Target Neighborhood Hits	128	Shared Neighborhood Hits	109
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

EFS_HUMAN
NC score	0.313493 (rank : 153)	θ value	0.163984 (rank : 239)
Query Neighborhood Hits	314	Target Neighborhood Hits	348	Shared Neighborhood Hits	152
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SH22A_MOUSE
NC score	0.311675 (rank : 154)	θ value	0.47712 (rank : 266)
Query Neighborhood Hits	314	Target Neighborhood Hits	179	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH22A_HUMAN
NC score	0.311199 (rank : 155)	θ value	0.0961366 (rank : 230)
Query Neighborhood Hits	314	Target Neighborhood Hits	144	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

NOXO1_MOUSE
NC score	0.308587 (rank : 156)	θ value	0.21417 (rank : 250)
Query Neighborhood Hits	314	Target Neighborhood Hits	114	Shared Neighborhood Hits	98
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

EPS8_MOUSE
NC score	0.307746 (rank : 157)	θ value	0.0113563 (rank : 175)
Query Neighborhood Hits	314	Target Neighborhood Hits	157	Shared Neighborhood Hits	125
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
NC score	0.305508 (rank : 158)	θ value	0.00298849 (rank : 147)
Query Neighborhood Hits	314	Target Neighborhood Hits	162	Shared Neighborhood Hits	104
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SH21A_MOUSE
NC score	0.304328 (rank : 159)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	314	Target Neighborhood Hits	89	Shared Neighborhood Hits	84
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

PEX13_MOUSE
NC score	0.304270 (rank : 160)	θ value	1.06291 (rank : 277)
Query Neighborhood Hits	314	Target Neighborhood Hits	126	Shared Neighborhood Hits	112
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CISH_HUMAN
NC score	0.303004 (rank : 161)	θ value	0.00869519 (rank : 168)
Query Neighborhood Hits	314	Target Neighborhood Hits	94	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

NEBU_HUMAN
NC score	0.302408 (rank : 162)	θ value	0.125558 (rank : 235)
Query Neighborhood Hits	314	Target Neighborhood Hits	420	Shared Neighborhood Hits	157
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SH21A_HUMAN
NC score	0.300407 (rank : 163)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	314	Target Neighborhood Hits	89	Shared Neighborhood Hits	83
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

CISH_MOUSE
NC score	0.299611 (rank : 164)	θ value	0.00869519 (rank : 169)
Query Neighborhood Hits	314	Target Neighborhood Hits	94	Shared Neighborhood Hits	85
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

FGR_MOUSE
NC score	0.296656 (rank : 165)	θ value	0.000461057 (rank : 102)
Query Neighborhood Hits	314	Target Neighborhood Hits	1069	Shared Neighborhood Hits	269
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_HUMAN
NC score	0.293360 (rank : 166)	θ value	0.000158464 (rank : 77)
Query Neighborhood Hits	314	Target Neighborhood Hits	1067	Shared Neighborhood Hits	264
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ES8L1_MOUSE
NC score	0.293299 (rank : 167)	θ value	0.000461057 (rank : 101)
Query Neighborhood Hits	314	Target Neighborhood Hits	143	Shared Neighborhood Hits	93
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ARHG9_HUMAN
NC score	0.291297 (rank : 168)	θ value	3.0926 (rank : 287)
Query Neighborhood Hits	314	Target Neighborhood Hits	235	Shared Neighborhood Hits	158
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

YES_MOUSE
NC score	0.290413 (rank : 169)	θ value	4.1701e-05 (rank : 60)
Query Neighborhood Hits	314	Target Neighborhood Hits	1052	Shared Neighborhood Hits	256
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

RUSC1_HUMAN
NC score	0.290036 (rank : 170)	θ value	0.0961366 (rank : 229)
Query Neighborhood Hits	314	Target Neighborhood Hits	226	Shared Neighborhood Hits	132
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ARHG9_MOUSE
NC score	0.289659 (rank : 171)	θ value	3.0926 (rank : 288)
Query Neighborhood Hits	314	Target Neighborhood Hits	234	Shared Neighborhood Hits	158
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

YES_HUMAN
NC score	0.289528 (rank : 172)	θ value	4.1701e-05 (rank : 59)
Query Neighborhood Hits	314	Target Neighborhood Hits	1059	Shared Neighborhood Hits	254
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.288900 (rank : 173)	θ value	0.000158464 (rank : 79)
Query Neighborhood Hits	314	Target Neighborhood Hits	1073	Shared Neighborhood Hits	263
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SRC_HUMAN
NC score	0.286363 (rank : 174)	θ value	0.000158464 (rank : 83)
Query Neighborhood Hits	314	Target Neighborhood Hits	1058	Shared Neighborhood Hits	266
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_HUMAN
NC score	0.285978 (rank : 175)	θ value	0.000158464 (rank : 78)
Query Neighborhood Hits	314	Target Neighborhood Hits	1078	Shared Neighborhood Hits	269
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SRGP2_MOUSE
NC score	0.283228 (rank : 176)	θ value	0.00390308 (rank : 156)
Query Neighborhood Hits	314	Target Neighborhood Hits	324	Shared Neighborhood Hits	153
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.282124 (rank : 177)	θ value	0.00298849 (rank : 149)
Query Neighborhood Hits	314	Target Neighborhood Hits	331	Shared Neighborhood Hits	152
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SPN90_HUMAN
NC score	0.281385 (rank : 178)	θ value	1.38821 (rank : 281)
Query Neighborhood Hits	314	Target Neighborhood Hits	157	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

PTN11_MOUSE
NC score	0.281036 (rank : 179)	θ value	2.44474e-05 (rank : 51)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.281003 (rank : 180)	θ value	2.44474e-05 (rank : 50)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

RIMB2_HUMAN
NC score	0.272846 (rank : 181)	θ value	0.279714 (rank : 256)
Query Neighborhood Hits	314	Target Neighborhood Hits	263	Shared Neighborhood Hits	120
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

MPP6_HUMAN
NC score	0.272550 (rank : 182)	θ value	0.00390308 (rank : 154)
Query Neighborhood Hits	314	Target Neighborhood Hits	180	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

RIMB2_MOUSE
NC score	0.269316 (rank : 183)	θ value	0.21417 (rank : 251)
Query Neighborhood Hits	314	Target Neighborhood Hits	246	Shared Neighborhood Hits	112
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SRC_MOUSE
NC score	0.269138 (rank : 184)	θ value	0.000158464 (rank : 84)
Query Neighborhood Hits	314	Target Neighborhood Hits	1033	Shared Neighborhood Hits	235
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP1_HUMAN
NC score	0.268519 (rank : 185)	θ value	0.0148317 (rank : 189)
Query Neighborhood Hits	314	Target Neighborhood Hits	390	Shared Neighborhood Hits	147
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

EM55_HUMAN
NC score	0.266874 (rank : 186)	θ value	0.00102713 (rank : 125)
Query Neighborhood Hits	314	Target Neighborhood Hits	228	Shared Neighborhood Hits	106
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

MPP6_MOUSE
NC score	0.264982 (rank : 187)	θ value	0.00390308 (rank : 155)
Query Neighborhood Hits	314	Target Neighborhood Hits	187	Shared Neighborhood Hits	94
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

FNBP2_HUMAN
NC score	0.264000 (rank : 188)	θ value	0.0431538 (rank : 210)
Query Neighborhood Hits	314	Target Neighborhood Hits	432	Shared Neighborhood Hits	148
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

EM55_MOUSE
NC score	0.262067 (rank : 189)	θ value	0.00102713 (rank : 126)
Query Neighborhood Hits	314	Target Neighborhood Hits	221	Shared Neighborhood Hits	102
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

FRK_HUMAN
NC score	0.261924 (rank : 190)	θ value	9.29e-05 (rank : 68)
Query Neighborhood Hits	314	Target Neighborhood Hits	1058	Shared Neighborhood Hits	259
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HCK_HUMAN
NC score	0.261907 (rank : 191)	θ value	0.000786445 (rank : 117)
Query Neighborhood Hits	314	Target Neighborhood Hits	1035	Shared Neighborhood Hits	231
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

CSK_MOUSE
NC score	0.261236 (rank : 192)	θ value	2.88788e-06 (rank : 32)
Query Neighborhood Hits	314	Target Neighborhood Hits	1009	Shared Neighborhood Hits	217
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.260721 (rank : 193)	θ value	2.21117e-06 (rank : 26)
Query Neighborhood Hits	314	Target Neighborhood Hits	1009	Shared Neighborhood Hits	217
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

BTK_HUMAN
NC score	0.260256 (rank : 194)	θ value	0.000602161 (rank : 110)
Query Neighborhood Hits	314	Target Neighborhood Hits	1026	Shared Neighborhood Hits	225
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

HCK_MOUSE
NC score	0.259739 (rank : 195)	θ value	0.0113563 (rank : 176)
Query Neighborhood Hits	314	Target Neighborhood Hits	1029	Shared Neighborhood Hits	225
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ARHG4_MOUSE
NC score	0.259558 (rank : 196)	θ value	0.163984 (rank : 237)
Query Neighborhood Hits	314	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ABL2_HUMAN
NC score	0.259483 (rank : 197)	θ value	1.29631e-06 (rank : 22)
Query Neighborhood Hits	314	Target Neighborhood Hits	1045	Shared Neighborhood Hits	198
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

SLY_MOUSE
NC score	0.258687 (rank : 198)	θ value	0.000461057 (rank : 108)
Query Neighborhood Hits	314	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

ANM2_HUMAN
NC score	0.257948 (rank : 199)	θ value	1.06291 (rank : 274)
Query Neighborhood Hits	314	Target Neighborhood Hits	175	Shared Neighborhood Hits	148
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ABL1_HUMAN
NC score	0.257913 (rank : 200)	θ value	1.69304e-06 (rank : 23)
Query Neighborhood Hits	314	Target Neighborhood Hits	1220	Shared Neighborhood Hits	208
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.257661 (rank : 201)	θ value	1.69304e-06 (rank : 24)
Query Neighborhood Hits	314	Target Neighborhood Hits	1178	Shared Neighborhood Hits	207
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

NOXO1_HUMAN
NC score	0.256506 (rank : 202)	θ value	0.0563607 (rank : 220)
Query Neighborhood Hits	314	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

BTK_MOUSE
NC score	0.256431 (rank : 203)	θ value	0.00228821 (rank : 142)
Query Neighborhood Hits	314	Target Neighborhood Hits	1017	Shared Neighborhood Hits	216
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

RUSC1_MOUSE
NC score	0.256315 (rank : 204)	θ value	0.163984 (rank : 241)
Query Neighborhood Hits	314	Target Neighborhood Hits	206	Shared Neighborhood Hits	124
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SOCS3_HUMAN
NC score	0.252905 (rank : 205)	θ value	0.0252991 (rank : 200)
Query Neighborhood Hits	314	Target Neighborhood Hits	77	Shared Neighborhood Hits	67
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SPN90_MOUSE
NC score	0.251032 (rank : 206)	θ value	2.36792 (rank : 286)
Query Neighborhood Hits	314	Target Neighborhood Hits	157	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

PTN6_MOUSE
NC score	0.248880 (rank : 207)	θ value	0.000461057 (rank : 106)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	132
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

LYN_MOUSE
NC score	0.247430 (rank : 208)	θ value	0.000158464 (rank : 81)
Query Neighborhood Hits	314	Target Neighborhood Hits	1023	Shared Neighborhood Hits	213
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.245703 (rank : 209)	θ value	0.00134147 (rank : 133)
Query Neighborhood Hits	314	Target Neighborhood Hits	1022	Shared Neighborhood Hits	212
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ANM2_MOUSE
NC score	0.244644 (rank : 210)	θ value	1.06291 (rank : 275)
Query Neighborhood Hits	314	Target Neighborhood Hits	175	Shared Neighborhood Hits	144
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

TXK_MOUSE
NC score	0.244231 (rank : 211)	θ value	0.000121331 (rank : 75)
Query Neighborhood Hits	314	Target Neighborhood Hits	980	Shared Neighborhood Hits	208
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SOCS3_MOUSE
NC score	0.243583 (rank : 212)	θ value	0.0252991 (rank : 201)
Query Neighborhood Hits	314	Target Neighborhood Hits	72	Shared Neighborhood Hits	68
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

PTK6_MOUSE
NC score	0.242161 (rank : 213)	θ value	0.00035302 (rank : 98)
Query Neighborhood Hits	314	Target Neighborhood Hits	1026	Shared Neighborhood Hits	230
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN6_HUMAN
NC score	0.241953 (rank : 214)	θ value	0.00175202 (rank : 140)
Query Neighborhood Hits	314	Target Neighborhood Hits	234	Shared Neighborhood Hits	126
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SPTA2_HUMAN
NC score	0.241456 (rank : 215)	θ value	1.43324e-05 (rank : 46)
Query Neighborhood Hits	314	Target Neighborhood Hits	888	Shared Neighborhood Hits	180
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

BLK_MOUSE
NC score	0.240951 (rank : 216)	θ value	0.125558 (rank : 232)
Query Neighborhood Hits	314	Target Neighborhood Hits	992	Shared Neighborhood Hits	193
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MPP4_MOUSE
NC score	0.240472 (rank : 217)	θ value	0.0148317 (rank : 184)
Query Neighborhood Hits	314	Target Neighborhood Hits	188	Shared Neighborhood Hits	75
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

SH24A_HUMAN
NC score	0.239276 (rank : 218)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	314	Target Neighborhood Hits	455	Shared Neighborhood Hits	100
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

PTK6_HUMAN
NC score	0.239235 (rank : 219)	θ value	3.19293e-05 (rank : 55)
Query Neighborhood Hits	314	Target Neighborhood Hits	1020	Shared Neighborhood Hits	230
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

MPP5_HUMAN
NC score	0.239192 (rank : 220)	θ value	0.00509761 (rank : 157)
Query Neighborhood Hits	314	Target Neighborhood Hits	231	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.238652 (rank : 221)	θ value	0.00509761 (rank : 158)
Query Neighborhood Hits	314	Target Neighborhood Hits	226	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

LCK_HUMAN
NC score	0.237908 (rank : 222)	θ value	0.0148317 (rank : 182)
Query Neighborhood Hits	314	Target Neighborhood Hits	987	Shared Neighborhood Hits	181
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BLK_HUMAN
NC score	0.237194 (rank : 223)	θ value	0.365318 (rank : 259)
Query Neighborhood Hits	314	Target Neighborhood Hits	994	Shared Neighborhood Hits	196
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SH24A_MOUSE
NC score	0.236695 (rank : 224)	θ value	5.27518 (rank : 301)
Query Neighborhood Hits	314	Target Neighborhood Hits	326	Shared Neighborhood Hits	91
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SPTA1_MOUSE
NC score	0.236531 (rank : 225)	θ value	3.19293e-05 (rank : 56)
Query Neighborhood Hits	314	Target Neighborhood Hits	675	Shared Neighborhood Hits	160
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SLY_HUMAN
NC score	0.235830 (rank : 226)	θ value	0.00228821 (rank : 145)
Query Neighborhood Hits	314	Target Neighborhood Hits	81	Shared Neighborhood Hits	58
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SOCS5_HUMAN
NC score	0.235809 (rank : 227)	θ value	0.00134147 (rank : 135)
Query Neighborhood Hits	314	Target Neighborhood Hits	91	Shared Neighborhood Hits	72
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

LCK_MOUSE
NC score	0.235566 (rank : 228)	θ value	0.0148317 (rank : 183)
Query Neighborhood Hits	314	Target Neighborhood Hits	981	Shared Neighborhood Hits	182
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SOCS5_MOUSE
NC score	0.235160 (rank : 229)	θ value	0.00134147 (rank : 136)
Query Neighborhood Hits	314	Target Neighborhood Hits	93	Shared Neighborhood Hits	72
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

TEC_HUMAN
NC score	0.233031 (rank : 230)	θ value	0.00035302 (rank : 99)
Query Neighborhood Hits	314	Target Neighborhood Hits	1006	Shared Neighborhood Hits	190
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
NC score	0.232950 (rank : 231)	θ value	0.00298849 (rank : 150)
Query Neighborhood Hits	314	Target Neighborhood Hits	971	Shared Neighborhood Hits	189
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

MPP4_HUMAN
NC score	0.230195 (rank : 232)	θ value	0.0113563 (rank : 177)
Query Neighborhood Hits	314	Target Neighborhood Hits	205	Shared Neighborhood Hits	70
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

TEC_MOUSE
NC score	0.229469 (rank : 233)	θ value	0.000270298 (rank : 95)
Query Neighborhood Hits	314	Target Neighborhood Hits	1006	Shared Neighborhood Hits	188
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MPP2_HUMAN
NC score	0.229058 (rank : 234)	θ value	0.365318 (rank : 260)
Query Neighborhood Hits	314	Target Neighborhood Hits	173	Shared Neighborhood Hits	87
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

SPTA1_HUMAN
NC score	0.227008 (rank : 235)	θ value	0.000270298 (rank : 94)
Query Neighborhood Hits	314	Target Neighborhood Hits	748	Shared Neighborhood Hits	168
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ITK_HUMAN
NC score	0.226920 (rank : 236)	θ value	0.000270298 (rank : 93)
Query Neighborhood Hits	314	Target Neighborhood Hits	1016	Shared Neighborhood Hits	192
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MPP2_MOUSE
NC score	0.226777 (rank : 237)	θ value	0.365318 (rank : 261)
Query Neighborhood Hits	314	Target Neighborhood Hits	189	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MATK_HUMAN
NC score	0.226483 (rank : 238)	θ value	5.81887e-07 (rank : 20)
Query Neighborhood Hits	314	Target Neighborhood Hits	954	Shared Neighborhood Hits	160
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
NC score	0.225968 (rank : 239)	θ value	7.59969e-07 (rank : 21)
Query Neighborhood Hits	314	Target Neighborhood Hits	952	Shared Neighborhood Hits	161
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

IASPP_HUMAN
NC score	0.224941 (rank : 240)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	314	Target Neighborhood Hits	688	Shared Neighborhood Hits	155
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LCP2_MOUSE
NC score	0.223977 (rank : 241)	θ value	2.36792 (rank : 285)
Query Neighborhood Hits	314	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

ITK_MOUSE
NC score	0.221601 (rank : 242)	θ value	0.00020696 (rank : 86)
Query Neighborhood Hits	314	Target Neighborhood Hits	985	Shared Neighborhood Hits	178
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SRMS_MOUSE
NC score	0.219324 (rank : 243)	θ value	0.000602161 (rank : 112)
Query Neighborhood Hits	314	Target Neighborhood Hits	964	Shared Neighborhood Hits	171
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

DDEF1_MOUSE
NC score	0.218581 (rank : 244)	θ value	0.0431538 (rank : 209)
Query Neighborhood Hits	314	Target Neighborhood Hits	592	Shared Neighborhood Hits	146
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ASPP1_HUMAN
NC score	0.216968 (rank : 245)	θ value	0.21417 (rank : 245)
Query Neighborhood Hits	314	Target Neighborhood Hits	956	Shared Neighborhood Hits	159
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SOCS1_MOUSE
NC score	0.216898 (rank : 246)	θ value	8.99809 (rank : 312)
Query Neighborhood Hits	314	Target Neighborhood Hits	82	Shared Neighborhood Hits	67
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS1_HUMAN
NC score	0.214309 (rank : 247)	θ value	8.99809 (rank : 311)
Query Neighborhood Hits	314	Target Neighborhood Hits	79	Shared Neighborhood Hits	65
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

CIP4_HUMAN
NC score	0.213000 (rank : 248)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	314	Target Neighborhood Hits	374	Shared Neighborhood Hits	89
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

SRMS_HUMAN
NC score	0.212316 (rank : 249)	θ value	0.00869519 (rank : 174)
Query Neighborhood Hits	314	Target Neighborhood Hits	946	Shared Neighborhood Hits	147
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

ASPP1_MOUSE
NC score	0.211185 (rank : 250)	θ value	0.163984 (rank : 238)
Query Neighborhood Hits	314	Target Neighborhood Hits	1244	Shared Neighborhood Hits	165
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SNX9_HUMAN
NC score	0.209420 (rank : 251)	θ value	6.88961 (rank : 306)
Query Neighborhood Hits	314	Target Neighborhood Hits	148	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SOCS4_MOUSE
NC score	0.208167 (rank : 252)	θ value	0.0148317 (rank : 188)
Query Neighborhood Hits	314	Target Neighborhood Hits	69	Shared Neighborhood Hits	50
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

FER_HUMAN
NC score	0.207660 (rank : 253)	θ value	0.000121331 (rank : 71)
Query Neighborhood Hits	314	Target Neighborhood Hits	1278	Shared Neighborhood Hits	149
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

IASPP_MOUSE
NC score	0.206241 (rank : 254)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	314	Target Neighborhood Hits	1024	Shared Neighborhood Hits	165
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SOCS4_HUMAN
NC score	0.205916 (rank : 255)	θ value	0.0148317 (rank : 187)
Query Neighborhood Hits	314	Target Neighborhood Hits	69	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

MYO1F_HUMAN
NC score	0.205564 (rank : 256)	θ value	0.0330416 (rank : 206)
Query Neighborhood Hits	314	Target Neighborhood Hits	275	Shared Neighborhood Hits	184
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.204302 (rank : 257)	θ value	0.0252991 (rank : 197)
Query Neighborhood Hits	314	Target Neighborhood Hits	262	Shared Neighborhood Hits	187
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

DLG2_MOUSE
NC score	0.203988 (rank : 258)	θ value	0.000270298 (rank : 91)
Query Neighborhood Hits	314	Target Neighborhood Hits	271	Shared Neighborhood Hits	86
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

MPP3_HUMAN
NC score	0.203279 (rank : 259)	θ value	0.0431538 (rank : 214)
Query Neighborhood Hits	314	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

DLG2_HUMAN
NC score	0.201949 (rank : 260)	θ value	0.00035302 (rank : 97)
Query Neighborhood Hits	314	Target Neighborhood Hits	279	Shared Neighborhood Hits	86
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

SNX9_MOUSE
NC score	0.201687 (rank : 261)	θ value	3.0926 (rank : 292)
Query Neighborhood Hits	314	Target Neighborhood Hits	141	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

MYO1E_HUMAN
NC score	0.201678 (rank : 262)	θ value	0.00665767 (rank : 165)
Query Neighborhood Hits	314	Target Neighborhood Hits	293	Shared Neighborhood Hits	178
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

TENS4_MOUSE
NC score	0.200922 (rank : 263)	θ value	0.125558 (rank : 236)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

DDEF2_HUMAN
NC score	0.199097 (rank : 264)	θ value	0.0148317 (rank : 180)
Query Neighborhood Hits	314	Target Neighborhood Hits	599	Shared Neighborhood Hits	146
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

MPP3_MOUSE
NC score	0.198574 (rank : 265)	θ value	0.125558 (rank : 234)
Query Neighborhood Hits	314	Target Neighborhood Hits	165	Shared Neighborhood Hits	47
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

DLG1_HUMAN
NC score	0.197914 (rank : 266)	θ value	0.000786445 (rank : 114)
Query Neighborhood Hits	314	Target Neighborhood Hits	290	Shared Neighborhood Hits	80
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG4_HUMAN
NC score	0.196100 (rank : 267)	θ value	0.00665767 (rank : 164)
Query Neighborhood Hits	314	Target Neighborhood Hits	286	Shared Neighborhood Hits	85
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

SAMN1_HUMAN
NC score	0.196074 (rank : 268)	θ value	0.0113563 (rank : 179)
Query Neighborhood Hits	314	Target Neighborhood Hits	74	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

DLG1_MOUSE
NC score	0.196008 (rank : 269)	θ value	0.00134147 (rank : 132)
Query Neighborhood Hits	314	Target Neighborhood Hits	285	Shared Neighborhood Hits	77
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

LCP2_HUMAN
NC score	0.195672 (rank : 270)	θ value	1.38821 (rank : 279)
Query Neighborhood Hits	314	Target Neighborhood Hits	531	Shared Neighborhood Hits	90
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

TENS4_HUMAN
NC score	0.195605 (rank : 271)	θ value	0.0736092 (rank : 225)
Query Neighborhood Hits	314	Target Neighborhood Hits	214	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

DDEF2_MOUSE
NC score	0.195490 (rank : 272)	θ value	0.0563607 (rank : 217)
Query Neighborhood Hits	314	Target Neighborhood Hits	625	Shared Neighborhood Hits	148
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

KSYK_MOUSE
NC score	0.194833 (rank : 273)	θ value	0.00390308 (rank : 152)
Query Neighborhood Hits	314	Target Neighborhood Hits	944	Shared Neighborhood Hits	126
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

DLG3_HUMAN
NC score	0.194011 (rank : 274)	θ value	0.00869519 (rank : 171)
Query Neighborhood Hits	314	Target Neighborhood Hits	269	Shared Neighborhood Hits	85
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
NC score	0.193218 (rank : 275)	θ value	0.00869519 (rank : 172)
Query Neighborhood Hits	314	Target Neighborhood Hits	274	Shared Neighborhood Hits	85
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

M3KL4_HUMAN
NC score	0.193018 (rank : 276)	θ value	0.125558 (rank : 233)
Query Neighborhood Hits	314	Target Neighborhood Hits	1087	Shared Neighborhood Hits	179
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

RHG26_HUMAN
NC score	0.191475 (rank : 277)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	314	Target Neighborhood Hits	281	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

KSYK_HUMAN
NC score	0.191140 (rank : 278)	θ value	0.0563607 (rank : 218)
Query Neighborhood Hits	314	Target Neighborhood Hits	901	Shared Neighborhood Hits	124
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

DLG4_MOUSE
NC score	0.189721 (rank : 279)	θ value	0.0148317 (rank : 181)
Query Neighborhood Hits	314	Target Neighborhood Hits	282	Shared Neighborhood Hits	81
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

CHIN_MOUSE
NC score	0.187458 (rank : 280)	θ value	1.81305 (rank : 282)
Query Neighborhood Hits	314	Target Neighborhood Hits	229	Shared Neighborhood Hits	113
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ASPP2_HUMAN
NC score	0.184977 (rank : 281)	θ value	0.0961366 (rank : 226)
Query Neighborhood Hits	314	Target Neighborhood Hits	1156	Shared Neighborhood Hits	152
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SAMN1_MOUSE
NC score	0.184662 (rank : 282)	θ value	0.0736092 (rank : 223)
Query Neighborhood Hits	314	Target Neighborhood Hits	69	Shared Neighborhood Hits	45
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_HUMAN
NC score	0.183435 (rank : 283)	θ value	0.0252991 (rank : 198)
Query Neighborhood Hits	314	Target Neighborhood Hits	292	Shared Neighborhood Hits	64
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SHAN2_MOUSE
NC score	0.181375 (rank : 284)	θ value	1.38821 (rank : 280)
Query Neighborhood Hits	314	Target Neighborhood Hits	446	Shared Neighborhood Hits	118
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

M3K11_HUMAN
NC score	0.181329 (rank : 285)	θ value	1.06291 (rank : 276)
Query Neighborhood Hits	314	Target Neighborhood Hits	1136	Shared Neighborhood Hits	182
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

ZAP70_MOUSE
NC score	0.180925 (rank : 286)	θ value	0.279714 (rank : 258)
Query Neighborhood Hits	314	Target Neighborhood Hits	905	Shared Neighborhood Hits	123
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_HUMAN
NC score	0.179604 (rank : 287)	θ value	0.279714 (rank : 257)
Query Neighborhood Hits	314	Target Neighborhood Hits	893	Shared Neighborhood Hits	122
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SASH1_MOUSE
NC score	0.178001 (rank : 288)	θ value	0.0193708 (rank : 196)
Query Neighborhood Hits	314	Target Neighborhood Hits	263	Shared Neighborhood Hits	60
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

BMX_MOUSE
NC score	0.177603 (rank : 289)	θ value	2.36792 (rank : 284)
Query Neighborhood Hits	314	Target Neighborhood Hits	912	Shared Neighborhood Hits	112
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BMX_HUMAN
NC score	0.177400 (rank : 290)	θ value	3.0926 (rank : 290)
Query Neighborhood Hits	314	Target Neighborhood Hits	942	Shared Neighborhood Hits	115
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

M3K9_HUMAN
NC score	0.176060 (rank : 291)	θ value	0.279714 (rank : 255)
Query Neighborhood Hits	314	Target Neighborhood Hits	1123	Shared Neighborhood Hits	179
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

RIMB1_HUMAN
NC score	0.175305 (rank : 292)	θ value	0.163984 (rank : 240)
Query Neighborhood Hits	314	Target Neighborhood Hits	1479	Shared Neighborhood Hits	155
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CHIN_HUMAN
NC score	0.173634 (rank : 293)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	105
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

M3K10_HUMAN
NC score	0.171785 (rank : 294)	θ value	0.0431538 (rank : 213)
Query Neighborhood Hits	314	Target Neighborhood Hits	1071	Shared Neighborhood Hits	166
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

RIMB1_MOUSE
NC score	0.169392 (rank : 295)	θ value	0.0431538 (rank : 215)
Query Neighborhood Hits	314	Target Neighborhood Hits	1376	Shared Neighborhood Hits	159
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CHIO_HUMAN
NC score	0.164358 (rank : 296)	θ value	5.27518 (rank : 297)
Query Neighborhood Hits	314	Target Neighborhood Hits	220	Shared Neighborhood Hits	101
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SHLB1_MOUSE
NC score	0.157479 (rank : 297)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	314	Target Neighborhood Hits	101	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

TCGAP_MOUSE
NC score	0.157359 (rank : 298)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	314	Target Neighborhood Hits	409	Shared Neighborhood Hits	120
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

FES_HUMAN
NC score	0.156378 (rank : 299)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	314	Target Neighborhood Hits	978	Shared Neighborhood Hits	108
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

KGUA_MOUSE
NC score	0.155901 (rank : 300)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	314	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

TENS1_HUMAN
NC score	0.155193 (rank : 301)	θ value	0.00228821 (rank : 146)
Query Neighborhood Hits	314	Target Neighborhood Hits	400	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

KGUA_HUMAN
NC score	0.154848 (rank : 302)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	314	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

SHLB2_MOUSE
NC score	0.154640 (rank : 303)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	314	Target Neighborhood Hits	88	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB1_HUMAN
NC score	0.153544 (rank : 304)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	314	Target Neighborhood Hits	96	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHAN1_HUMAN
NC score	0.149720 (rank : 305)	θ value	0.365318 (rank : 263)
Query Neighborhood Hits	314	Target Neighborhood Hits	1041	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHLB2_HUMAN
NC score	0.149127 (rank : 306)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	314	Target Neighborhood Hits	86	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

FES_MOUSE
NC score	0.147949 (rank : 307)	θ value	3.0926 (rank : 291)
Query Neighborhood Hits	314	Target Neighborhood Hits	980	Shared Neighborhood Hits	93
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

BLNK_MOUSE
NC score	0.147211 (rank : 308)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	314	Target Neighborhood Hits	296	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

ARHG5_HUMAN
NC score	0.145058 (rank : 309)	θ value	8.99809 (rank : 309)
Query Neighborhood Hits	314	Target Neighborhood Hits	172	Shared Neighborhood Hits	87
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

TCGAP_HUMAN
NC score	0.140578 (rank : 310)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	314	Target Neighborhood Hits	872	Shared Neighborhood Hits	129
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

NGEF_MOUSE
NC score	0.140482 (rank : 311)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	314	Target Neighborhood Hits	228	Shared Neighborhood Hits	78
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

BLNK_HUMAN
NC score	0.139564 (rank : 312)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	314	Target Neighborhood Hits	228	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

NGEF_HUMAN
NC score	0.136629 (rank : 313)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	314	Target Neighborhood Hits	166	Shared Neighborhood Hits	72
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ACK1_MOUSE
NC score	0.132403 (rank : 314)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	314	Target Neighborhood Hits	1080	Shared Neighborhood Hits	92
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACK1_HUMAN
NC score	0.131099 (rank : 315)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	314	Target Neighborhood Hits	1140	Shared Neighborhood Hits	87
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

CSKP_HUMAN
NC score	0.127410 (rank : 316)	θ value	0.00228821 (rank : 143)
Query Neighborhood Hits	314	Target Neighborhood Hits	1022	Shared Neighborhood Hits	144
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
NC score	0.126449 (rank : 317)	θ value	0.00228821 (rank : 144)
Query Neighborhood Hits	314	Target Neighborhood Hits	1027	Shared Neighborhood Hits	151
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

MCF2L_MOUSE
NC score	0.126199 (rank : 318)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	314	Target Neighborhood Hits	255	Shared Neighborhood Hits	49
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

STYK1_HUMAN
NC score	0.125764 (rank : 319)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	314	Target Neighborhood Hits	786	Shared Neighborhood Hits	50
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

PKHG1_HUMAN
NC score	0.125248 (rank : 320)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	314	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

RYK_HUMAN
NC score	0.125153 (rank : 321)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	314	Target Neighborhood Hits	701	Shared Neighborhood Hits	48
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

LTK_HUMAN
NC score	0.124909 (rank : 322)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	314	Target Neighborhood Hits	774	Shared Neighborhood Hits	50
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

STYK1_MOUSE
NC score	0.124803 (rank : 323)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	314	Target Neighborhood Hits	779	Shared Neighborhood Hits	50
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

RYK_MOUSE
NC score	0.124007 (rank : 324)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	314	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

LTK_MOUSE
NC score	0.124002 (rank : 325)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	314	Target Neighborhood Hits	770	Shared Neighborhood Hits	51
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ALK_MOUSE
NC score	0.123075 (rank : 326)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	314	Target Neighborhood Hits	811	Shared Neighborhood Hits	53
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_HUMAN
NC score	0.122459 (rank : 327)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	314	Target Neighborhood Hits	795	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ROS_HUMAN
NC score	0.120400 (rank : 328)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	314	Target Neighborhood Hits	907	Shared Neighborhood Hits	52
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

STS2_HUMAN
NC score	0.120237 (rank : 329)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	314	Target Neighborhood Hits	108	Shared Neighborhood Hits	80
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TNK1_HUMAN
NC score	0.119668 (rank : 330)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	314	Target Neighborhood Hits	815	Shared Neighborhood Hits	56
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
NC score	0.119168 (rank : 331)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	314	Target Neighborhood Hits	806	Shared Neighborhood Hits	57
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

DDR1_MOUSE
NC score	0.118278 (rank : 332)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	314	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

FAK2_HUMAN
NC score	0.117913 (rank : 333)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

DDR1_HUMAN
NC score	0.117748 (rank : 334)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	314	Target Neighborhood Hits	819	Shared Neighborhood Hits	52
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

EPHB6_HUMAN
NC score	0.117265 (rank : 335)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	314	Target Neighborhood Hits	912	Shared Neighborhood Hits	57
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

FAK2_MOUSE
NC score	0.117250 (rank : 336)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

PREX1_HUMAN
NC score	0.116946 (rank : 337)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	314	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

EPHAA_HUMAN
NC score	0.116694 (rank : 338)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	314	Target Neighborhood Hits	960	Shared Neighborhood Hits	58
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

FLT3_MOUSE
NC score	0.116298 (rank : 339)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

EPHB6_MOUSE
NC score	0.116050 (rank : 340)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	314	Target Neighborhood Hits	906	Shared Neighborhood Hits	55
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

TEX14_HUMAN
NC score	0.116016 (rank : 341)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	314	Target Neighborhood Hits	1103	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ERBB3_HUMAN
NC score	0.116010 (rank : 342)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	314	Target Neighborhood Hits	918	Shared Neighborhood Hits	51
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
NC score	0.115650 (rank : 343)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	314	Target Neighborhood Hits	898	Shared Neighborhood Hits	51
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

FLT3_HUMAN
NC score	0.115635 (rank : 344)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	50
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

AATK_MOUSE
NC score	0.115478 (rank : 345)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	314	Target Neighborhood Hits	942	Shared Neighborhood Hits	52
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ERBB2_HUMAN
NC score	0.115185 (rank : 346)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	314	Target Neighborhood Hits	1073	Shared Neighborhood Hits	53
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
NC score	0.115167 (rank : 347)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	314	Target Neighborhood Hits	918	Shared Neighborhood Hits	52
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

NTRK1_HUMAN
NC score	0.115040 (rank : 348)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	314	Target Neighborhood Hits	1023	Shared Neighborhood Hits	50
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

IGF1R_MOUSE
NC score	0.114977 (rank : 349)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	314	Target Neighborhood Hits	973	Shared Neighborhood Hits	51
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_HUMAN
NC score	0.114939 (rank : 350)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	314	Target Neighborhood Hits	977	Shared Neighborhood Hits	51
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ERBB4_HUMAN
NC score	0.114903 (rank : 351)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	314	Target Neighborhood Hits	910	Shared Neighborhood Hits	53
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

CSF1R_HUMAN
NC score	0.114666 (rank : 352)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	314	Target Neighborhood Hits	943	Shared Neighborhood Hits	50
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

INSRR_HUMAN
NC score	0.114452 (rank : 353)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	314	Target Neighborhood Hits	950	Shared Neighborhood Hits	51
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

RON_MOUSE
NC score	0.114200 (rank : 354)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	51
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

MERTK_HUMAN
NC score	0.114145 (rank : 355)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	314	Target Neighborhood Hits	988	Shared Neighborhood Hits	49
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

INSRR_MOUSE
NC score	0.114013 (rank : 356)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	314	Target Neighborhood Hits	961	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ROR2_MOUSE
NC score	0.113565 (rank : 357)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	314	Target Neighborhood Hits	1000	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

MERTK_MOUSE
NC score	0.113562 (rank : 358)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	314	Target Neighborhood Hits	974	Shared Neighborhood Hits	49
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

TEX14_MOUSE
NC score	0.113539 (rank : 359)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	314	Target Neighborhood Hits	1333	Shared Neighborhood Hits	68
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

FAK1_MOUSE
NC score	0.113433 (rank : 360)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK1_HUMAN
NC score	0.113429 (rank : 361)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

ARHGG_MOUSE
NC score	0.112935 (rank : 362)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	314	Target Neighborhood Hits	152	Shared Neighborhood Hits	56
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

EPHA6_HUMAN
NC score	0.112902 (rank : 363)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	314	Target Neighborhood Hits	959	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

DDR2_HUMAN
NC score	0.112884 (rank : 364)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	314	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ARHG3_MOUSE
NC score	0.112815 (rank : 365)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	314	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

EPHA6_MOUSE
NC score	0.112784 (rank : 366)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	314	Target Neighborhood Hits	946	Shared Neighborhood Hits	56
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ARHG3_HUMAN
NC score	0.112778 (rank : 367)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	314	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

EPHA1_MOUSE
NC score	0.112720 (rank : 368)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	314	Target Neighborhood Hits	958	Shared Neighborhood Hits	57
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

PGFRB_MOUSE
NC score	0.112599 (rank : 369)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	314	Target Neighborhood Hits	960	Shared Neighborhood Hits	52
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

AATK_HUMAN
NC score	0.112481 (rank : 370)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	314	Target Neighborhood Hits	1243	Shared Neighborhood Hits	61
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

TIAM1_MOUSE
NC score	0.112466 (rank : 371)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	314	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

KIT_MOUSE
NC score	0.112448 (rank : 372)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	314	Target Neighborhood Hits	949	Shared Neighborhood Hits	51
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

DDR2_MOUSE
NC score	0.112444 (rank : 373)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	314	Target Neighborhood Hits	813	Shared Neighborhood Hits	50
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

RON_HUMAN
NC score	0.112371 (rank : 374)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	314	Target Neighborhood Hits	842	Shared Neighborhood Hits	50
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

INSR_HUMAN
NC score	0.112349 (rank : 375)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	314	Target Neighborhood Hits	963	Shared Neighborhood Hits	51
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

PGFRB_HUMAN
NC score	0.112310 (rank : 376)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	314	Target Neighborhood Hits	962	Shared Neighborhood Hits	50
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRA_MOUSE
NC score	0.112244 (rank : 377)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	314	Target Neighborhood Hits	975	Shared Neighborhood Hits	50
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

DOCK1_HUMAN
NC score	0.112132 (rank : 378)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	314	Target Neighborhood Hits	191	Shared Neighborhood Hits	111
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

EPHA5_MOUSE
NC score	0.112081 (rank : 379)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	314	Target Neighborhood Hits	950	Shared Neighborhood Hits	56
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EGFR_HUMAN
NC score	0.112077 (rank : 380)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	314	Target Neighborhood Hits	939	Shared Neighborhood Hits	51
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
NC score	0.112048 (rank : 381)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	314	Target Neighborhood Hits	927	Shared Neighborhood Hits	50
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
NC score	0.111962 (rank : 382)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	314	Target Neighborhood Hits	997	Shared Neighborhood Hits	56
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

PGFRA_HUMAN
NC score	0.111921 (rank : 383)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	314	Target Neighborhood Hits	980	Shared Neighborhood Hits	50
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

INSR_MOUSE
NC score	0.111870 (rank : 384)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	314	Target Neighborhood Hits	968	Shared Neighborhood Hits	51
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

UFO_HUMAN
NC score	0.111561 (rank : 385)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	314	Target Neighborhood Hits	981	Shared Neighborhood Hits	51
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
NC score	0.111536 (rank : 386)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	314	Target Neighborhood Hits	988	Shared Neighborhood Hits	53
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

KIT_HUMAN
NC score	0.111502 (rank : 387)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	314	Target Neighborhood Hits	953	Shared Neighborhood Hits	50
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

RET_HUMAN
NC score	0.111500 (rank : 388)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	314	Target Neighborhood Hits	873	Shared Neighborhood Hits	50
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

CSF1R_MOUSE
NC score	0.111496 (rank : 389)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	314	Target Neighborhood Hits	983	Shared Neighborhood Hits	50
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

NTRK3_HUMAN
NC score	0.111287 (rank : 390)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	314	Target Neighborhood Hits	1115	Shared Neighborhood Hits	50
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

ROR2_HUMAN
NC score	0.111168 (rank : 391)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	314	Target Neighborhood Hits	1014	Shared Neighborhood Hits	50
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ILK_MOUSE
NC score	0.110934 (rank : 392)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	314	Target Neighborhood Hits	858	Shared Neighborhood Hits	63
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

TIAM1_HUMAN
NC score	0.110758 (rank : 393)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	314	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

RET_MOUSE
NC score	0.110600 (rank : 394)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	314	Target Neighborhood Hits	884	Shared Neighborhood Hits	50
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

MET_MOUSE
NC score	0.110584 (rank : 395)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	314	Target Neighborhood Hits	844	Shared Neighborhood Hits	50
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHA2_MOUSE
NC score	0.110506 (rank : 396)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	314	Target Neighborhood Hits	1020	Shared Neighborhood Hits	60
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

MET_HUMAN
NC score	0.110176 (rank : 397)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	314	Target Neighborhood Hits	831	Shared Neighborhood Hits	50
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHA2_HUMAN
NC score	0.110154 (rank : 398)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	314	Target Neighborhood Hits	1021	Shared Neighborhood Hits	60
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ILK1_HUMAN
NC score	0.109947 (rank : 399)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	314	Target Neighborhood Hits	857	Shared Neighborhood Hits	63
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ROR1_MOUSE
NC score	0.109947 (rank : 400)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	314	Target Neighborhood Hits	1025	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

TYRO3_MOUSE
NC score	0.109702 (rank : 401)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	314	Target Neighborhood Hits	1007	Shared Neighborhood Hits	51
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ROR1_HUMAN
NC score	0.109597 (rank : 402)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	314	Target Neighborhood Hits	1018	Shared Neighborhood Hits	50
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

EPHB3_MOUSE
NC score	0.109401 (rank : 403)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	314	Target Neighborhood Hits	996	Shared Neighborhood Hits	59
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

TYRO3_HUMAN
NC score	0.109275 (rank : 404)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	314	Target Neighborhood Hits	995	Shared Neighborhood Hits	50
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHB3_HUMAN
NC score	0.109259 (rank : 405)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	314	Target Neighborhood Hits	996	Shared Neighborhood Hits	59
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB4_HUMAN
NC score	0.109034 (rank : 406)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	314	Target Neighborhood Hits	1056	Shared Neighborhood Hits	57
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

FGFR4_MOUSE
NC score	0.108970 (rank : 407)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	314	Target Neighborhood Hits	1026	Shared Neighborhood Hits	50
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

EPHA8_MOUSE
NC score	0.108928 (rank : 408)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	314	Target Neighborhood Hits	969	Shared Neighborhood Hits	58
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

ILK2_HUMAN
NC score	0.108915 (rank : 409)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	314	Target Neighborhood Hits	848	Shared Neighborhood Hits	63
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

EPHB4_MOUSE
NC score	0.108625 (rank : 410)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	314	Target Neighborhood Hits	1013	Shared Neighborhood Hits	57
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA8_HUMAN
NC score	0.108601 (rank : 411)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	314	Target Neighborhood Hits	956	Shared Neighborhood Hits	57
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHB2_HUMAN
NC score	0.108355 (rank : 412)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	314	Target Neighborhood Hits	983	Shared Neighborhood Hits	56
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
NC score	0.108348 (rank : 413)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	314	Target Neighborhood Hits	982	Shared Neighborhood Hits	56
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHA4_MOUSE
NC score	0.108200 (rank : 414)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	314	Target Neighborhood Hits	982	Shared Neighborhood Hits	55
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA4_HUMAN
NC score	0.108179 (rank : 415)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	314	Target Neighborhood Hits	975	Shared Neighborhood Hits	55
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA5_HUMAN
NC score	0.107665 (rank : 416)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	314	Target Neighborhood Hits	1009	Shared Neighborhood Hits	58
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

NTRK2_MOUSE
NC score	0.107272 (rank : 417)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	314	Target Neighborhood Hits	1088	Shared Neighborhood Hits	50
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.107260 (rank : 418)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	314	Target Neighborhood Hits	1081	Shared Neighborhood Hits	50
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

EPHB1_HUMAN
NC score	0.107209 (rank : 419)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	314	Target Neighborhood Hits	988	Shared Neighborhood Hits	57
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

FGFR4_HUMAN
NC score	0.106900 (rank : 420)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	314	Target Neighborhood Hits	1037	Shared Neighborhood Hits	50
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

STS1_MOUSE
NC score	0.106486 (rank : 421)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	314	Target Neighborhood Hits	104	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

MLKL_HUMAN
NC score	0.106235 (rank : 422)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	314	Target Neighborhood Hits	600	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

EPHA7_MOUSE
NC score	0.106112 (rank : 423)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	314	Target Neighborhood Hits	1025	Shared Neighborhood Hits	57
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA7_HUMAN
NC score	0.105999 (rank : 424)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	314	Target Neighborhood Hits	1053	Shared Neighborhood Hits	58
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA3_MOUSE
NC score	0.105985 (rank : 425)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	314	Target Neighborhood Hits	1009	Shared Neighborhood Hits	53
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA3_HUMAN
NC score	0.105749 (rank : 426)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	314	Target Neighborhood Hits	1005	Shared Neighborhood Hits	53
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

TIE1_HUMAN
NC score	0.105529 (rank : 427)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	314	Target Neighborhood Hits	1241	Shared Neighborhood Hits	51
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
NC score	0.105130 (rank : 428)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	314	Target Neighborhood Hits	1266	Shared Neighborhood Hits	52
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

MUSK_MOUSE
NC score	0.105061 (rank : 429)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	314	Target Neighborhood Hits	1057	Shared Neighborhood Hits	50
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

STS1_HUMAN
NC score	0.104915 (rank : 430)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	314	Target Neighborhood Hits	106	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ARHG8_MOUSE
NC score	0.104883 (rank : 431)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	314	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

JAK1_MOUSE
NC score	0.104796 (rank : 432)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	314	Target Neighborhood Hits	854	Shared Neighborhood Hits	57
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

MUSK_HUMAN
NC score	0.104671 (rank : 433)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	314	Target Neighborhood Hits	1074	Shared Neighborhood Hits	50
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

RUSC2_HUMAN
NC score	0.104574 (rank : 434)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	314	Target Neighborhood Hits	205	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TIE2_HUMAN
NC score	0.104502 (rank : 435)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	314	Target Neighborhood Hits	1192	Shared Neighborhood Hits	53
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

FGFR3_HUMAN
NC score	0.104414 (rank : 436)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	314	Target Neighborhood Hits	1042	Shared Neighborhood Hits	51
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

TIE2_MOUSE
NC score	0.104359 (rank : 437)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	314	Target Neighborhood Hits	1204	Shared Neighborhood Hits	53
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

MLKL_MOUSE
NC score	0.104291 (rank : 438)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	314	Target Neighborhood Hits	707	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

JAK1_HUMAN
NC score	0.103936 (rank : 439)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	314	Target Neighborhood Hits	858	Shared Neighborhood Hits	57
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

FGFR3_MOUSE
NC score	0.103680 (rank : 440)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	314	Target Neighborhood Hits	1059	Shared Neighborhood Hits	50
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR2_MOUSE
NC score	0.103520 (rank : 441)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	314	Target Neighborhood Hits	1062	Shared Neighborhood Hits	50
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR2_HUMAN
NC score	0.103046 (rank : 442)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	314	Target Neighborhood Hits	1062	Shared Neighborhood Hits	50
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

DLG5_HUMAN
NC score	0.102748 (rank : 443)	θ value	0.0330416 (rank : 204)
Query Neighborhood Hits	314	Target Neighborhood Hits	1088	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

VGFR3_HUMAN
NC score	0.102746 (rank : 444)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	314	Target Neighborhood Hits	1037	Shared Neighborhood Hits	50
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR1_MOUSE
NC score	0.102712 (rank : 445)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	314	Target Neighborhood Hits	1068	Shared Neighborhood Hits	51
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.102701 (rank : 446)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	314	Target Neighborhood Hits	1069	Shared Neighborhood Hits	51
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

VGFR3_MOUSE
NC score	0.102589 (rank : 447)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	314	Target Neighborhood Hits	1056	Shared Neighborhood Hits	50
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

GUC2F_HUMAN
NC score	0.101669 (rank : 448)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	314	Target Neighborhood Hits	740	Shared Neighborhood Hits	48
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ARHG8_HUMAN
NC score	0.101454 (rank : 449)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	314	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

PTK7_HUMAN
NC score	0.101290 (rank : 450)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	314	Target Neighborhood Hits	1103	Shared Neighborhood Hits	50
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

TYK2_MOUSE
NC score	0.100758 (rank : 451)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK3_HUMAN
NC score	0.099801 (rank : 452)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	314	Target Neighborhood Hits	827	Shared Neighborhood Hits	50
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

VGFR2_MOUSE
NC score	0.099583 (rank : 453)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	314	Target Neighborhood Hits	1089	Shared Neighborhood Hits	50
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR2_HUMAN
NC score	0.099409 (rank : 454)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	314	Target Neighborhood Hits	1103	Shared Neighborhood Hits	50
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

TYK2_HUMAN
NC score	0.099409 (rank : 455)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	314	Target Neighborhood Hits	841	Shared Neighborhood Hits	50
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

ANPRA_MOUSE
NC score	0.099077 (rank : 456)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	314	Target Neighborhood Hits	600	Shared Neighborhood Hits	48
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.099066 (rank : 457)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	314	Target Neighborhood Hits	612	Shared Neighborhood Hits	48
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

GUC2C_HUMAN
NC score	0.098862 (rank : 458)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	314	Target Neighborhood Hits	624	Shared Neighborhood Hits	48
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

ARHGG_HUMAN
NC score	0.098542 (rank : 459)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	314	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

VGFR1_HUMAN
NC score	0.097662 (rank : 460)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	314	Target Neighborhood Hits	1109	Shared Neighborhood Hits	50
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

JAK2_MOUSE
NC score	0.097659 (rank : 461)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	314	Target Neighborhood Hits	839	Shared Neighborhood Hits	53
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

VGFR1_MOUSE
NC score	0.097155 (rank : 462)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	314	Target Neighborhood Hits	1118	Shared Neighborhood Hits	50
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

RAF1_HUMAN
NC score	0.097066 (rank : 463)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

JAK2_HUMAN
NC score	0.096934 (rank : 464)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	52
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

ARAF_MOUSE
NC score	0.096884 (rank : 465)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	60
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

BRAF1_HUMAN
NC score	0.096849 (rank : 466)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	314	Target Neighborhood Hits	883	Shared Neighborhood Hits	62
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

ECT2_MOUSE
NC score	0.096792 (rank : 467)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	314	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARAF_HUMAN
NC score	0.096663 (rank : 468)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	314	Target Neighborhood Hits	924	Shared Neighborhood Hits	63
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

RAF1_MOUSE
NC score	0.096516 (rank : 469)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

AMPH_HUMAN
NC score	0.096304 (rank : 470)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	314	Target Neighborhood Hits	455	Shared Neighborhood Hits	79
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

JAK3_MOUSE
NC score	0.096123 (rank : 471)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	314	Target Neighborhood Hits	821	Shared Neighborhood Hits	50
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

MCF2_HUMAN
NC score	0.095945 (rank : 472)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	314	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

IRAK3_MOUSE
NC score	0.095827 (rank : 473)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	314	Target Neighborhood Hits	628	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ARHGA_MOUSE
NC score	0.095433 (rank : 474)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	314	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MLTK_MOUSE
NC score	0.095269 (rank : 475)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.095207 (rank : 476)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	314	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

ANPRB_MOUSE
NC score	0.094532 (rank : 477)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	314	Target Neighborhood Hits	607	Shared Neighborhood Hits	52
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

MOS_HUMAN
NC score	0.094071 (rank : 478)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	314	Target Neighborhood Hits	829	Shared Neighborhood Hits	50
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ANPRB_HUMAN
NC score	0.093817 (rank : 479)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	314	Target Neighborhood Hits	646	Shared Neighborhood Hits	52
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

JIP1_HUMAN
NC score	0.093737 (rank : 480)	θ value	0.62314 (rank : 267)
Query Neighborhood Hits	314	Target Neighborhood Hits	271	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ECT2_HUMAN
NC score	0.093389 (rank : 481)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	314	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RIPK1_MOUSE
NC score	0.093260 (rank : 482)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	51
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

MOS_MOUSE
NC score	0.092752 (rank : 483)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

BI2L1_HUMAN
NC score	0.092380 (rank : 484)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	314	Target Neighborhood Hits	156	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

KSR2_HUMAN
NC score	0.092012 (rank : 485)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	314	Target Neighborhood Hits	920	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

GUC2G_MOUSE
NC score	0.091751 (rank : 486)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	314	Target Neighborhood Hits	644	Shared Neighborhood Hits	45
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

RIPK1_HUMAN
NC score	0.091632 (rank : 487)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	314	Target Neighborhood Hits	891	Shared Neighborhood Hits	50
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

KSR1_HUMAN
NC score	0.091543 (rank : 488)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

ARHGC_HUMAN
NC score	0.090759 (rank : 489)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	314	Target Neighborhood Hits	351	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

IRAK3_HUMAN
NC score	0.090617 (rank : 490)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	314	Target Neighborhood Hits	644	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

M3K12_HUMAN
NC score	0.090459 (rank : 491)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	314	Target Neighborhood Hits	940	Shared Neighborhood Hits	53
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.090329 (rank : 492)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	314	Target Neighborhood Hits	957	Shared Neighborhood Hits	54
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

JIP1_MOUSE
NC score	0.090249 (rank : 493)	θ value	0.813845 (rank : 270)
Query Neighborhood Hits	314	Target Neighborhood Hits	259	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ARHGC_MOUSE
NC score	0.090075 (rank : 494)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	314	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGA_HUMAN
NC score	0.089879 (rank : 495)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	314	Target Neighborhood Hits	187	Shared Neighborhood Hits	22
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

KSR1_MOUSE
NC score	0.089874 (rank : 496)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	314	Target Neighborhood Hits	870	Shared Neighborhood Hits	56
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

M3K13_HUMAN
NC score	0.089863 (rank : 497)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	314	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

IRAK1_MOUSE
NC score	0.089791 (rank : 498)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	314	Target Neighborhood Hits	784	Shared Neighborhood Hits	48
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

ARHGB_HUMAN
NC score	0.089132 (rank : 499)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	314	Target Neighborhood Hits	375	Shared Neighborhood Hits	39
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

BIN1_HUMAN
NC score	0.089040 (rank : 500)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	314	Target Neighborhood Hits	335	Shared Neighborhood Hits	65
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

RUSC2_MOUSE
NC score	0.088928 (rank : 501)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	314	Target Neighborhood Hits	305	Shared Neighborhood Hits	69
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

GUC2D_HUMAN
NC score	0.088922 (rank : 502)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	314	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
NC score	0.088683 (rank : 503)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	314	Target Neighborhood Hits	692	Shared Neighborhood Hits	47
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

BAIP2_MOUSE
NC score	0.088661 (rank : 504)	θ value	5.27518 (rank : 295)
Query Neighborhood Hits	314	Target Neighborhood Hits	185	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

TRIO_HUMAN
NC score	0.088276 (rank : 505)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	314	Target Neighborhood Hits	1580	Shared Neighborhood Hits	100
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

BMR1B_MOUSE
NC score	0.088172 (rank : 506)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	314	Target Neighborhood Hits	758	Shared Neighborhood Hits	48
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMR1B_HUMAN
NC score	0.088066 (rank : 507)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	314	Target Neighborhood Hits	760	Shared Neighborhood Hits	48
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BIN1_MOUSE
NC score	0.088030 (rank : 508)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	314	Target Neighborhood Hits	283	Shared Neighborhood Hits	65
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

RIPK2_MOUSE
NC score	0.087721 (rank : 509)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	314	Target Neighborhood Hits	776	Shared Neighborhood Hits	50
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

M3K7_MOUSE
NC score	0.087363 (rank : 510)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	314	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.087331 (rank : 511)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	314	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

RIPK3_HUMAN
NC score	0.086875 (rank : 512)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	314	Target Neighborhood Hits	828	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

BMR1A_MOUSE
NC score	0.086810 (rank : 513)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	314	Target Neighborhood Hits	758	Shared Neighborhood Hits	50
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

AMPH_MOUSE
NC score	0.086624 (rank : 514)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	314	Target Neighborhood Hits	291	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BMR1A_HUMAN
NC score	0.086579 (rank : 515)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	314	Target Neighborhood Hits	759	Shared Neighborhood Hits	50
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

RIPK3_MOUSE
NC score	0.086549 (rank : 516)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

BAIP2_HUMAN
NC score	0.086522 (rank : 517)	θ value	5.27518 (rank : 294)
Query Neighborhood Hits	314	Target Neighborhood Hits	192	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

RHG12_MOUSE
NC score	0.086512 (rank : 518)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	314	Target Neighborhood Hits	204	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RIPK2_HUMAN
NC score	0.086227 (rank : 519)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	314	Target Neighborhood Hits	774	Shared Neighborhood Hits	50
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RHG12_HUMAN
NC score	0.086202 (rank : 520)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	314	Target Neighborhood Hits	190	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

IRAK1_HUMAN
NC score	0.085504 (rank : 521)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	314	Target Neighborhood Hits	820	Shared Neighborhood Hits	50
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TNI3K_MOUSE
NC score	0.085094 (rank : 522)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	314	Target Neighborhood Hits	1079	Shared Neighborhood Hits	63
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_HUMAN
NC score	0.084688 (rank : 523)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	314	Target Neighborhood Hits	1084	Shared Neighborhood Hits	63
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

IRAK4_HUMAN
NC score	0.084658 (rank : 524)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	314	Target Neighborhood Hits	816	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

LIMK1_HUMAN
NC score	0.084293 (rank : 525)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	314	Target Neighborhood Hits	1005	Shared Neighborhood Hits	64
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.084046 (rank : 526)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	314	Target Neighborhood Hits	1008	Shared Neighborhood Hits	64
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

TESK2_HUMAN
NC score	0.083800 (rank : 527)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	51
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ACVL1_HUMAN
NC score	0.083095 (rank : 528)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	314	Target Neighborhood Hits	716	Shared Neighborhood Hits	50
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TESK2_MOUSE
NC score	0.082737 (rank : 529)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ACVL1_MOUSE
NC score	0.082388 (rank : 530)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	314	Target Neighborhood Hits	739	Shared Neighborhood Hits	50
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TOPK_HUMAN
NC score	0.082162 (rank : 531)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	314	Target Neighborhood Hits	605	Shared Neighborhood Hits	48
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

ARHG1_HUMAN
NC score	0.082147 (rank : 532)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	314	Target Neighborhood Hits	176	Shared Neighborhood Hits	19
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

TOPK_MOUSE
NC score	0.082077 (rank : 533)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	314	Target Neighborhood Hits	618	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

IRAK4_MOUSE
NC score	0.082010 (rank : 534)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	314	Target Neighborhood Hits	820	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ACV1C_HUMAN
NC score	0.081761 (rank : 535)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	314	Target Neighborhood Hits	709	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ZO3_HUMAN
NC score	0.081710 (rank : 536)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	314	Target Neighborhood Hits	219	Shared Neighborhood Hits	27
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

LIMK2_MOUSE
NC score	0.081650 (rank : 537)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	314	Target Neighborhood Hits	998	Shared Neighborhood Hits	64
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

TESK1_HUMAN
NC score	0.081581 (rank : 538)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	314	Target Neighborhood Hits	864	Shared Neighborhood Hits	55
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

LIMK2_HUMAN
NC score	0.081423 (rank : 539)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	314	Target Neighborhood Hits	986	Shared Neighborhood Hits	66
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

ACV1C_MOUSE
NC score	0.081292 (rank : 540)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	314	Target Neighborhood Hits	715	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

TESK1_MOUSE
NC score	0.081043 (rank : 541)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	314	Target Neighborhood Hits	862	Shared Neighborhood Hits	52
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

AB1IP_MOUSE
NC score	0.080739 (rank : 542)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	314	Target Neighborhood Hits	181	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

BI2L1_MOUSE
NC score	0.080284 (rank : 543)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	314	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

TGFR1_HUMAN
NC score	0.080239 (rank : 544)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	314	Target Neighborhood Hits	755	Shared Neighborhood Hits	50
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

AB1IP_HUMAN
NC score	0.080184 (rank : 545)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	314	Target Neighborhood Hits	213	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

TGFR1_MOUSE
NC score	0.080135 (rank : 546)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	314	Target Neighborhood Hits	753	Shared Neighborhood Hits	50
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

IRAK2_HUMAN
NC score	0.080120 (rank : 547)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	314	Target Neighborhood Hits	714	Shared Neighborhood Hits	50
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

RIPK5_HUMAN
NC score	0.079189 (rank : 548)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	314	Target Neighborhood Hits	864	Shared Neighborhood Hits	51
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

PPIP2_HUMAN
NC score	0.079189 (rank : 549)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	314	Target Neighborhood Hits	254	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

JIP2_MOUSE
NC score	0.079136 (rank : 550)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	314	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

RIPK5_MOUSE
NC score	0.079060 (rank : 551)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

JIP2_HUMAN
NC score	0.078549 (rank : 552)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	314	Target Neighborhood Hits	288	Shared Neighborhood Hits	61
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ACV1B_MOUSE
NC score	0.078516 (rank : 553)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	314	Target Neighborhood Hits	753	Shared Neighborhood Hits	50
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.078445 (rank : 554)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	314	Target Neighborhood Hits	753	Shared Neighborhood Hits	50
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ZO3_MOUSE
NC score	0.077996 (rank : 555)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	314	Target Neighborhood Hits	224	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

BCR_HUMAN
NC score	0.077171 (rank : 556)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	314	Target Neighborhood Hits	204	Shared Neighborhood Hits	31
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

AMHR2_HUMAN
NC score	0.076708 (rank : 557)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	314	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANKK1_MOUSE
NC score	0.076395 (rank : 558)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	314	Target Neighborhood Hits	1072	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ACVR1_MOUSE
NC score	0.076275 (rank : 559)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	314	Target Neighborhood Hits	768	Shared Neighborhood Hits	50
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ACVR1_HUMAN
NC score	0.075814 (rank : 560)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	314	Target Neighborhood Hits	760	Shared Neighborhood Hits	50
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ANKK1_HUMAN
NC score	0.075695 (rank : 561)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	314	Target Neighborhood Hits	1075	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

RIPK4_HUMAN
NC score	0.075430 (rank : 562)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	314	Target Neighborhood Hits	1094	Shared Neighborhood Hits	61
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

GNRP_MOUSE
NC score	0.075109 (rank : 563)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	314	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD3_MOUSE
NC score	0.075077 (rank : 564)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	314	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ZO2_MOUSE
NC score	0.074527 (rank : 565)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	314	Target Neighborhood Hits	296	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

LRRK1_MOUSE
NC score	0.074454 (rank : 566)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	314	Target Neighborhood Hits	1267	Shared Neighborhood Hits	55
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_HUMAN
NC score	0.074255 (rank : 567)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	314	Target Neighborhood Hits	1237	Shared Neighborhood Hits	56
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

ABR_HUMAN
NC score	0.074140 (rank : 568)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	314	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

HAPIP_HUMAN
NC score	0.073969 (rank : 569)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	314	Target Neighborhood Hits	350	Shared Neighborhood Hits	26
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

DUET_HUMAN
NC score	0.073791 (rank : 570)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	314	Target Neighborhood Hits	1220	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

RHG09_HUMAN
NC score	0.073417 (rank : 571)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	314	Target Neighborhood Hits	186	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

ARHG1_MOUSE
NC score	0.073268 (rank : 572)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	314	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

LBC_HUMAN
NC score	0.073094 (rank : 573)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	314	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

RAPH1_HUMAN
NC score	0.072712 (rank : 574)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	314	Target Neighborhood Hits	593	Shared Neighborhood Hits	40
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

LRRK2_MOUSE
NC score	0.072186 (rank : 575)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	314	Target Neighborhood Hits	1359	Shared Neighborhood Hits	52
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LRRK2_HUMAN
NC score	0.072096 (rank : 576)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	314	Target Neighborhood Hits	1382	Shared Neighborhood Hits	50
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

PPIP2_MOUSE
NC score	0.071861 (rank : 577)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	314	Target Neighborhood Hits	308	Shared Neighborhood Hits	19
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

CI096_HUMAN
NC score	0.071577 (rank : 578)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	314	Target Neighborhood Hits	821	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

ZO2_HUMAN
NC score	0.071470 (rank : 579)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	314	Target Neighborhood Hits	289	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

FGD3_HUMAN
NC score	0.070856 (rank : 580)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	314	Target Neighborhood Hits	249	Shared Neighborhood Hits	21
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_MOUSE
NC score	0.070397 (rank : 581)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	314	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
NC score	0.069603 (rank : 582)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	314	Target Neighborhood Hits	219	Shared Neighborhood Hits	26
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ZO1_HUMAN
NC score	0.069283 (rank : 583)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	314	Target Neighborhood Hits	474	Shared Neighborhood Hits	45
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

NEK11_HUMAN
NC score	0.069146 (rank : 584)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	314	Target Neighborhood Hits	1043	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
NC score	0.069015 (rank : 585)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	314	Target Neighborhood Hits	875	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

BMPR2_HUMAN
NC score	0.068401 (rank : 586)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	314	Target Neighborhood Hits	736	Shared Neighborhood Hits	51
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

GNRP_HUMAN
NC score	0.068055 (rank : 587)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	314	Target Neighborhood Hits	239	Shared Neighborhood Hits	22
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

BMPR2_MOUSE
NC score	0.067888 (rank : 588)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	314	Target Neighborhood Hits	738	Shared Neighborhood Hits	51
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

ZO1_MOUSE
NC score	0.067791 (rank : 589)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	314	Target Neighborhood Hits	453	Shared Neighborhood Hits	37
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

FGD2_HUMAN
NC score	0.066624 (rank : 590)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	314	Target Neighborhood Hits	151	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

STK39_HUMAN
NC score	0.066522 (rank : 591)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	314	Target Neighborhood Hits	882	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
NC score	0.066499 (rank : 592)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	314	Target Neighborhood Hits	915	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

OXSR1_MOUSE
NC score	0.066157 (rank : 593)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	314	Target Neighborhood Hits	865	Shared Neighborhood Hits	50
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_HUMAN
NC score	0.065985 (rank : 594)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

RGNEF_MOUSE
NC score	0.065768 (rank : 595)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	314	Target Neighborhood Hits	641	Shared Neighborhood Hits	38
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

AVR2B_MOUSE
NC score	0.065484 (rank : 596)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	314	Target Neighborhood Hits	749	Shared Neighborhood Hits	50
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.065397 (rank : 597)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	314	Target Neighborhood Hits	748	Shared Neighborhood Hits	50
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

ARHG2_HUMAN
NC score	0.065371 (rank : 598)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	314	Target Neighborhood Hits	142	Shared Neighborhood Hits	25
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

TTBK1_HUMAN
NC score	0.064747 (rank : 599)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	314	Target Neighborhood Hits	1058	Shared Neighborhood Hits	53
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

AVR2A_MOUSE
NC score	0.064581 (rank : 600)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	314	Target Neighborhood Hits	767	Shared Neighborhood Hits	50
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.064579 (rank : 601)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	314	Target Neighborhood Hits	767	Shared Neighborhood Hits	50
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

STK16_MOUSE
NC score	0.063811 (rank : 602)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	314	Target Neighborhood Hits	824	Shared Neighborhood Hits	51
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

YSK4_HUMAN
NC score	0.063764 (rank : 603)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	314	Target Neighborhood Hits	921	Shared Neighborhood Hits	50
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

STK24_MOUSE
NC score	0.063761 (rank : 604)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	314	Target Neighborhood Hits	856	Shared Neighborhood Hits	50
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

FGD2_MOUSE
NC score	0.063676 (rank : 605)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	314	Target Neighborhood Hits	163	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_HUMAN
NC score	0.063500 (rank : 606)	θ value	5.27518 (rank : 298)
Query Neighborhood Hits	314	Target Neighborhood Hits	367	Shared Neighborhood Hits	32
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MST4_HUMAN
NC score	0.063354 (rank : 607)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	314	Target Neighborhood Hits	852	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

STK24_HUMAN
NC score	0.063248 (rank : 608)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	314	Target Neighborhood Hits	853	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

MST4_MOUSE
NC score	0.063228 (rank : 609)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	314	Target Neighborhood Hits	860	Shared Neighborhood Hits	50
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

NEK7_HUMAN
NC score	0.062952 (rank : 610)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	314	Target Neighborhood Hits	846	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
NC score	0.062865 (rank : 611)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

MYLK2_HUMAN
NC score	0.062746 (rank : 612)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	314	Target Neighborhood Hits	920	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NEK6_MOUSE
NC score	0.062726 (rank : 613)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

PKHG4_HUMAN
NC score	0.062586 (rank : 614)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	314	Target Neighborhood Hits	200	Shared Neighborhood Hits	21
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

NEK6_HUMAN
NC score	0.062560 (rank : 615)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	314	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

KPCB_MOUSE
NC score	0.062473 (rank : 616)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	314	Target Neighborhood Hits	1117	Shared Neighborhood Hits	68
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

WNK2_HUMAN
NC score	0.062416 (rank : 617)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	314	Target Neighborhood Hits	1407	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

E2AK2_MOUSE
NC score	0.062385 (rank : 618)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	314	Target Neighborhood Hits	864	Shared Neighborhood Hits	50
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

STK25_MOUSE
NC score	0.062351 (rank : 619)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK16_HUMAN
NC score	0.062168 (rank : 620)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	314	Target Neighborhood Hits	824	Shared Neighborhood Hits	50
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK25_HUMAN
NC score	0.062000 (rank : 621)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	314	Target Neighborhood Hits	853	Shared Neighborhood Hits	50
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

KPCB_HUMAN
NC score	0.061930 (rank : 622)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	314	Target Neighborhood Hits	1121	Shared Neighborhood Hits	68
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

AL2S2_MOUSE
NC score	0.061834 (rank : 623)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	314	Target Neighborhood Hits	709	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

TAOK2_MOUSE
NC score	0.061710 (rank : 624)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	314	Target Neighborhood Hits	1373	Shared Neighborhood Hits	66
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

APBA1_HUMAN
NC score	0.061676 (rank : 625)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	314	Target Neighborhood Hits	325	Shared Neighborhood Hits	34
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

M4K4_MOUSE
NC score	0.060667 (rank : 626)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	314	Target Neighborhood Hits	1560	Shared Neighborhood Hits	68
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

TAOK2_HUMAN
NC score	0.060660 (rank : 627)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	314	Target Neighborhood Hits	1172	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

LIN7B_MOUSE
NC score	0.060608 (rank : 628)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	314	Target Neighborhood Hits	200	Shared Neighborhood Hits	27
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

NEK4_MOUSE
NC score	0.060589 (rank : 629)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	314	Target Neighborhood Hits	899	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

LIN7C_HUMAN
NC score	0.060585 (rank : 630)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.060585 (rank : 631)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	314	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7B_HUMAN
NC score	0.060584 (rank : 632)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	314	Target Neighborhood Hits	200	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MP2K5_MOUSE
NC score	0.060521 (rank : 633)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	314	Target Neighborhood Hits	840	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

KPCA_MOUSE
NC score	0.060231 (rank : 634)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	314	Target Neighborhood Hits	1067	Shared Neighborhood Hits	70
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

GRIP1_MOUSE
NC score	0.060009 (rank : 635)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	314	Target Neighborhood Hits	241	Shared Neighborhood Hits	28
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

NEK4_HUMAN
NC score	0.059914 (rank : 636)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	314	Target Neighborhood Hits	883	Shared Neighborhood Hits	50
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

TGFR2_MOUSE
NC score	0.059846 (rank : 637)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	314	Target Neighborhood Hits	748	Shared Neighborhood Hits	50
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_HUMAN
NC score	0.059824 (rank : 638)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	314	Target Neighborhood Hits	748	Shared Neighborhood Hits	50
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

AL2S7_HUMAN
NC score	0.059794 (rank : 639)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	314	Target Neighborhood Hits	831	Shared Neighborhood Hits	51
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

KPCA_HUMAN
NC score	0.059780 (rank : 640)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	314	Target Neighborhood Hits	1070	Shared Neighborhood Hits	70
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

ARHG2_MOUSE
NC score	0.059778 (rank : 641)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	314	Target Neighborhood Hits	120	Shared Neighborhood Hits	23
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

TTBK2_MOUSE
NC score	0.059727 (rank : 642)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	314	Target Neighborhood Hits	811	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

ULK1_MOUSE
NC score	0.059690 (rank : 643)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	314	Target Neighborhood Hits	1214	Shared Neighborhood Hits	73
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

KPCD_HUMAN
NC score	0.059666 (rank : 644)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	314	Target Neighborhood Hits	900	Shared Neighborhood Hits	62
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

NEK3_HUMAN
NC score	0.059664 (rank : 645)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	314	Target Neighborhood Hits	865	Shared Neighborhood Hits	50
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

SN1L2_HUMAN
NC score	0.059627 (rank : 646)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	314	Target Neighborhood Hits	964	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

MAK_MOUSE
NC score	0.059504 (rank : 647)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	314	Target Neighborhood Hits	873	Shared Neighborhood Hits	52
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

LIN7A_MOUSE
NC score	0.059453 (rank : 648)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	314	Target Neighborhood Hits	193	Shared Neighborhood Hits	25
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.059361 (rank : 649)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	314	Target Neighborhood Hits	193	Shared Neighborhood Hits	25
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

MP2K2_HUMAN
NC score	0.059333 (rank : 650)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

FGD1_MOUSE
NC score	0.059315 (rank : 651)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	314	Target Neighborhood Hits	387	Shared Neighborhood Hits	30
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MP2K2_MOUSE
NC score	0.059269 (rank : 652)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	314	Target Neighborhood Hits	828	Shared Neighborhood Hits	50
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

KC1D_HUMAN
NC score	0.059238 (rank : 653)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	314	Target Neighborhood Hits	737	Shared Neighborhood Hits	47
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.059232 (rank : 654)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	314	Target Neighborhood Hits	737	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

IKKA_HUMAN
NC score	0.059203 (rank : 655)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	314	Target Neighborhood Hits	863	Shared Neighborhood Hits	50
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

SN1L2_MOUSE
NC score	0.059174 (rank : 656)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	314	Target Neighborhood Hits	944	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

ICK_HUMAN
NC score	0.059170 (rank : 657)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

AL2S2_HUMAN
NC score	0.059169 (rank : 658)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	314	Target Neighborhood Hits	727	Shared Neighborhood Hits	48
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

TTBK2_HUMAN
NC score	0.059128 (rank : 659)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	314	Target Neighborhood Hits	822	Shared Neighborhood Hits	45
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

GRIP1_HUMAN
NC score	0.059074 (rank : 660)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	314	Target Neighborhood Hits	231	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

WNK1_MOUSE
NC score	0.058932 (rank : 661)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	314	Target Neighborhood Hits	1179	Shared Neighborhood Hits	59
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

ICK_MOUSE
NC score	0.058925 (rank : 662)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	314	Target Neighborhood Hits	860	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

APBA2_MOUSE
NC score	0.058851 (rank : 663)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	314	Target Neighborhood Hits	219	Shared Neighborhood Hits	34
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

MP2K7_HUMAN
NC score	0.058846 (rank : 664)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

KPCD_MOUSE
NC score	0.058800 (rank : 665)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	314	Target Neighborhood Hits	888	Shared Neighborhood Hits	62
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

CD2L7_HUMAN
NC score	0.058798 (rank : 666)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	314	Target Neighborhood Hits	1275	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

TSSK4_HUMAN
NC score	0.058660 (rank : 667)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	50
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

WNK3_HUMAN
NC score	0.058609 (rank : 668)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	314	Target Neighborhood Hits	948	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

BRSK2_HUMAN
NC score	0.058571 (rank : 669)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	314	Target Neighborhood Hits	897	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

WNK1_HUMAN
NC score	0.058560 (rank : 670)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	314	Target Neighborhood Hits	1158	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

SBK1_MOUSE
NC score	0.058444 (rank : 671)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	314	Target Neighborhood Hits	824	Shared Neighborhood Hits	51
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

ULK1_HUMAN
NC score	0.058435 (rank : 672)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	314	Target Neighborhood Hits	1121	Shared Neighborhood Hits	59
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

NEK3_MOUSE
NC score	0.058429 (rank : 673)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	314	Target Neighborhood Hits	854	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

MAK_HUMAN
NC score	0.058395 (rank : 674)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	314	Target Neighborhood Hits	857	Shared Neighborhood Hits	52
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

ULK2_MOUSE
NC score	0.058341 (rank : 675)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	314	Target Neighborhood Hits	943	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

KPCT_HUMAN
NC score	0.058296 (rank : 676)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	314	Target Neighborhood Hits	897	Shared Neighborhood Hits	62
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

E2AK1_HUMAN
NC score	0.058278 (rank : 677)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CD2L5_HUMAN
NC score	0.058231 (rank : 678)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	314	Target Neighborhood Hits	987	Shared Neighborhood Hits	55
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

NUAK1_MOUSE
NC score	0.058221 (rank : 679)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	314	Target Neighborhood Hits	881	Shared Neighborhood Hits	50
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

MP2K5_HUMAN
NC score	0.058215 (rank : 680)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

APBA2_HUMAN
NC score	0.058155 (rank : 681)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	314	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

NUAK1_HUMAN
NC score	0.058147 (rank : 682)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	51
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

IKKA_MOUSE
NC score	0.058136 (rank : 683)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	50
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

E2AK2_HUMAN
NC score	0.057916 (rank : 684)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	314	Target Neighborhood Hits	856	Shared Neighborhood Hits	50
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

ULK2_HUMAN
NC score	0.057865 (rank : 685)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	314	Target Neighborhood Hits	979	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

CD2L5_MOUSE
NC score	0.057859 (rank : 686)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	314	Target Neighborhood Hits	1011	Shared Neighborhood Hits	52
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

ARHGF_HUMAN
NC score	0.057634 (rank : 687)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	314	Target Neighborhood Hits	214	Shared Neighborhood Hits	22
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

TSSK4_MOUSE
NC score	0.057617 (rank : 688)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	314	Target Neighborhood Hits	840	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

SBK1_HUMAN
NC score	0.057424 (rank : 689)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	314	Target Neighborhood Hits	828	Shared Neighborhood Hits	51
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

NEK1_HUMAN
NC score	0.057423 (rank : 690)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	314	Target Neighborhood Hits	1129	Shared Neighborhood Hits	56
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

MP2K1_MOUSE
NC score	0.057382 (rank : 691)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

NEK1_MOUSE
NC score	0.057329 (rank : 692)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	314	Target Neighborhood Hits	1311	Shared Neighborhood Hits	58
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

MP2K1_HUMAN
NC score	0.057228 (rank : 693)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

STK3_HUMAN
NC score	0.057218 (rank : 694)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	314	Target Neighborhood Hits	861	Shared Neighborhood Hits	50
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

GRIP2_HUMAN
NC score	0.057173 (rank : 695)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	314	Target Neighborhood Hits	256	Shared Neighborhood Hits	25
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

M3K3_HUMAN
NC score	0.057160 (rank : 696)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	314	Target Neighborhood Hits	885	Shared Neighborhood Hits	53
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

ULK3_HUMAN
NC score	0.057089 (rank : 697)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

STK4_MOUSE
NC score	0.057070 (rank : 698)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	314	Target Neighborhood Hits	873	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

KPCT_MOUSE
NC score	0.057013 (rank : 699)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	314	Target Neighborhood Hits	895	Shared Neighborhood Hits	62
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

STK3_MOUSE
NC score	0.057012 (rank : 700)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	314	Target Neighborhood Hits	869	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
NC score	0.057002 (rank : 701)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	314	Target Neighborhood Hits	870	Shared Neighborhood Hits	50
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

SN1L1_MOUSE
NC score	0.056933 (rank : 702)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	314	Target Neighborhood Hits	895	Shared Neighborhood Hits	55
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

BRSK1_HUMAN
NC score	0.056933 (rank : 703)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	314	Target Neighborhood Hits	942	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

KPCG_MOUSE
NC score	0.056912 (rank : 704)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	314	Target Neighborhood Hits	1123	Shared Neighborhood Hits	70
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MARK4_MOUSE
NC score	0.056888 (rank : 705)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	314	Target Neighborhood Hits	898	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MARK4_HUMAN
NC score	0.056871 (rank : 706)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

KPCG_HUMAN
NC score	0.056824 (rank : 707)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	314	Target Neighborhood Hits	1126	Shared Neighborhood Hits	70
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MP2K4_HUMAN
NC score	0.056792 (rank : 708)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

NIM1_HUMAN
NC score	0.056707 (rank : 709)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

MP2K4_MOUSE
NC score	0.056697 (rank : 710)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

KC1E_MOUSE
NC score	0.056684 (rank : 711)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	314	Target Neighborhood Hits	728	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

TAOK1_HUMAN
NC score	0.056682 (rank : 712)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	314	Target Neighborhood Hits	1734	Shared Neighborhood Hits	68
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

KC1E_HUMAN
NC score	0.056678 (rank : 713)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	314	Target Neighborhood Hits	732	Shared Neighborhood Hits	45
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

M3K3_MOUSE
NC score	0.056678 (rank : 714)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	314	Target Neighborhood Hits	876	Shared Neighborhood Hits	53
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

TNIK_HUMAN
NC score	0.056676 (rank : 715)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	314	Target Neighborhood Hits	1570	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

MARK3_HUMAN
NC score	0.056592 (rank : 716)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	314	Target Neighborhood Hits	893	Shared Neighborhood Hits	54
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

TAOK1_MOUSE
NC score	0.056576 (rank : 717)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	314	Target Neighborhood Hits	1720	Shared Neighborhood Hits	67
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

NIM1_MOUSE
NC score	0.056558 (rank : 718)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	314	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

IKKE_MOUSE
NC score	0.056515 (rank : 719)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	314	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KPCD2_HUMAN
NC score	0.056512 (rank : 720)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	314	Target Neighborhood Hits	910	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

TSSK1_MOUSE
NC score	0.056484 (rank : 721)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	314	Target Neighborhood Hits	835	Shared Neighborhood Hits	50
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MARK3_MOUSE
NC score	0.056471 (rank : 722)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	314	Target Neighborhood Hits	919	Shared Neighborhood Hits	54
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK2_HUMAN
NC score	0.056376 (rank : 723)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	314	Target Neighborhood Hits	1056	Shared Neighborhood Hits	56
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK1_MOUSE
NC score	0.056336 (rank : 724)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

NEK2_HUMAN
NC score	0.056301 (rank : 725)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	314	Target Neighborhood Hits	908	Shared Neighborhood Hits	52
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

MP2K3_MOUSE
NC score	0.056292 (rank : 726)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

M3K15_HUMAN
NC score	0.056277 (rank : 727)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	314	Target Neighborhood Hits	914	Shared Neighborhood Hits	51
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

E2AK3_HUMAN
NC score	0.056192 (rank : 728)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	314	Target Neighborhood Hits	859	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

MINK1_MOUSE
NC score	0.056152 (rank : 729)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	314	Target Neighborhood Hits	1451	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MARK1_HUMAN
NC score	0.056138 (rank : 730)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	314	Target Neighborhood Hits	887	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MINK1_HUMAN
NC score	0.056135 (rank : 731)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	314	Target Neighborhood Hits	1477	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

NUAK2_HUMAN
NC score	0.056122 (rank : 732)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

CDK9_MOUSE
NC score	0.056083 (rank : 733)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	314	Target Neighborhood Hits	822	Shared Neighborhood Hits	50
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

AAPK1_HUMAN
NC score	0.055992 (rank : 734)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	314	Target Neighborhood Hits	842	Shared Neighborhood Hits	50
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

CDK9_HUMAN
NC score	0.055961 (rank : 735)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	314	Target Neighborhood Hits	822	Shared Neighborhood Hits	50
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

SN1L1_HUMAN
NC score	0.055940 (rank : 736)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	314	Target Neighborhood Hits	911	Shared Neighborhood Hits	50
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

PFTK1_MOUSE
NC score	0.055789 (rank : 737)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	314	Target Neighborhood Hits	835	Shared Neighborhood Hits	50
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

AAPK1_MOUSE
NC score	0.055759 (rank : 738)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	50
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
NC score	0.055699 (rank : 739)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	50
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

CDK3_MOUSE
NC score	0.055602 (rank : 740)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	314	Target Neighborhood Hits	829	Shared Neighborhood Hits	50
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

NEK2_MOUSE
NC score	0.055579 (rank : 741)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	314	Target Neighborhood Hits	876	Shared Neighborhood Hits	51
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

FGD6_MOUSE
NC score	0.055578 (rank : 742)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	314	Target Neighborhood Hits	282	Shared Neighborhood Hits	27
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

K0999_MOUSE
NC score	0.055562 (rank : 743)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	314	Target Neighborhood Hits	931	Shared Neighborhood Hits	53
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KPCD3_HUMAN
NC score	0.055557 (rank : 744)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	314	Target Neighborhood Hits	895	Shared Neighborhood Hits	62
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

E2AK3_MOUSE
NC score	0.055530 (rank : 745)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	314	Target Neighborhood Hits	851	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

TAOK3_HUMAN
NC score	0.055491 (rank : 746)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	314	Target Neighborhood Hits	1494	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

ULK3_MOUSE
NC score	0.055471 (rank : 747)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	314	Target Neighborhood Hits	872	Shared Neighborhood Hits	50
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

MP2K3_HUMAN
NC score	0.055433 (rank : 748)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	314	Target Neighborhood Hits	825	Shared Neighborhood Hits	50
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

TAOK3_MOUSE
NC score	0.055398 (rank : 749)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	314	Target Neighborhood Hits	1458	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

PFTK1_HUMAN
NC score	0.055394 (rank : 750)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	314	Target Neighborhood Hits	834	Shared Neighborhood Hits	50
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

IKKB_HUMAN
NC score	0.055385 (rank : 751)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	314	Target Neighborhood Hits	980	Shared Neighborhood Hits	50
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

FARP2_MOUSE
NC score	0.055370 (rank : 752)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	314	Target Neighborhood Hits	209	Shared Neighborhood Hits	25
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CDK3_HUMAN
NC score	0.055311 (rank : 753)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	50
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

K0999_HUMAN
NC score	0.055300 (rank : 754)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	314	Target Neighborhood Hits	899	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MK11_HUMAN
NC score	0.055296 (rank : 755)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	314	Target Neighborhood Hits	823	Shared Neighborhood Hits	50
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MP2K6_MOUSE
NC score	0.055291 (rank : 756)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

KPCD3_MOUSE
NC score	0.055261 (rank : 757)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	314	Target Neighborhood Hits	901	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

MARK2_MOUSE
NC score	0.055169 (rank : 758)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	314	Target Neighborhood Hits	1018	Shared Neighborhood Hits	54
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MP2K6_HUMAN
NC score	0.055155 (rank : 759)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

NUAK2_MOUSE
NC score	0.054914 (rank : 760)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	314	Target Neighborhood Hits	878	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

KPCD1_HUMAN
NC score	0.054833 (rank : 761)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	314	Target Neighborhood Hits	901	Shared Neighborhood Hits	62
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

NEK8_HUMAN
NC score	0.054824 (rank : 762)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	314	Target Neighborhood Hits	872	Shared Neighborhood Hits	50
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

PCTK1_MOUSE
NC score	0.054718 (rank : 763)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

CDK5_MOUSE
NC score	0.054690 (rank : 764)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

PCTK2_MOUSE
NC score	0.054687 (rank : 765)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

M4K4_HUMAN
NC score	0.054681 (rank : 766)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	314	Target Neighborhood Hits	1589	Shared Neighborhood Hits	68
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

CDK5_HUMAN
NC score	0.054613 (rank : 767)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

PCTK2_HUMAN
NC score	0.054566 (rank : 768)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	51
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK1_HUMAN
NC score	0.054521 (rank : 769)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

NEK8_MOUSE
NC score	0.054487 (rank : 770)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	314	Target Neighborhood Hits	872	Shared Neighborhood Hits	50
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

M3K2_HUMAN
NC score	0.054481 (rank : 771)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	314	Target Neighborhood Hits	849	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

PLK2_MOUSE
NC score	0.054370 (rank : 772)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	314	Target Neighborhood Hits	849	Shared Neighborhood Hits	50
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

IKKB_MOUSE
NC score	0.054321 (rank : 773)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	314	Target Neighborhood Hits	984	Shared Neighborhood Hits	53
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
NC score	0.054308 (rank : 774)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

PLK2_HUMAN
NC score	0.054296 (rank : 775)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	314	Target Neighborhood Hits	854	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLCD1_MOUSE
NC score	0.054270 (rank : 776)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	314	Target Neighborhood Hits	106	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

STK11_HUMAN
NC score	0.054215 (rank : 777)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	314	Target Neighborhood Hits	831	Shared Neighborhood Hits	50
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

TSSK2_HUMAN
NC score	0.054215 (rank : 778)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	314	Target Neighborhood Hits	826	Shared Neighborhood Hits	50
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

STK10_HUMAN
NC score	0.054178 (rank : 779)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	314	Target Neighborhood Hits	1921	Shared Neighborhood Hits	79
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

KPCD1_MOUSE
NC score	0.054174 (rank : 780)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	314	Target Neighborhood Hits	891	Shared Neighborhood Hits	62
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MK14_HUMAN
NC score	0.054068 (rank : 781)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK04_HUMAN
NC score	0.054059 (rank : 782)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	51
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

HUNK_MOUSE
NC score	0.054014 (rank : 783)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	314	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

CDC2_HUMAN
NC score	0.053969 (rank : 784)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	314	Target Neighborhood Hits	842	Shared Neighborhood Hits	50
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

E2AK1_MOUSE
NC score	0.053965 (rank : 785)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	314	Target Neighborhood Hits	821	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

M4K1_MOUSE
NC score	0.053933 (rank : 786)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	314	Target Neighborhood Hits	858	Shared Neighborhood Hits	51
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

HUNK_HUMAN
NC score	0.053824 (rank : 787)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	314	Target Neighborhood Hits	884	Shared Neighborhood Hits	50
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

CDC2_MOUSE
NC score	0.053793 (rank : 788)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

TTK_HUMAN
NC score	0.053704 (rank : 789)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	314	Target Neighborhood Hits	816	Shared Neighborhood Hits	50
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

MK14_MOUSE
NC score	0.053701 (rank : 790)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

CHIO_MOUSE
NC score	0.053523 (rank : 791)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	314	Target Neighborhood Hits	130	Shared Neighborhood Hits	20
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

M3K5_MOUSE
NC score	0.053510 (rank : 792)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	50
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

PRP4B_HUMAN
NC score	0.053474 (rank : 793)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	314	Target Neighborhood Hits	1030	Shared Neighborhood Hits	56
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

TBK1_HUMAN
NC score	0.053424 (rank : 794)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	314	Target Neighborhood Hits	861	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

M3K5_HUMAN
NC score	0.053396 (rank : 795)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	314	Target Neighborhood Hits	868	Shared Neighborhood Hits	50
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

DAPK3_HUMAN
NC score	0.053364 (rank : 796)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	314	Target Neighborhood Hits	945	Shared Neighborhood Hits	54
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

STK10_MOUSE
NC score	0.053349 (rank : 797)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	314	Target Neighborhood Hits	2132	Shared Neighborhood Hits	80
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

PIM1_HUMAN
NC score	0.053322 (rank : 798)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	314	Target Neighborhood Hits	797	Shared Neighborhood Hits	49
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PRP4B_MOUSE
NC score	0.053276 (rank : 799)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	314	Target Neighborhood Hits	1040	Shared Neighborhood Hits	56
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

NEK9_HUMAN
NC score	0.053233 (rank : 800)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	314	Target Neighborhood Hits	900	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

MK04_MOUSE
NC score	0.053141 (rank : 801)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	314	Target Neighborhood Hits	852	Shared Neighborhood Hits	52
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

TBK1_MOUSE
NC score	0.052908 (rank : 802)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	314	Target Neighborhood Hits	893	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

MK01_MOUSE
NC score	0.052896 (rank : 803)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	50
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

M4K1_HUMAN
NC score	0.052824 (rank : 804)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	314	Target Neighborhood Hits	884	Shared Neighborhood Hits	50
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

KPCE_MOUSE
NC score	0.052760 (rank : 805)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	314	Target Neighborhood Hits	906	Shared Neighborhood Hits	63
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

TSSK2_MOUSE
NC score	0.052758 (rank : 806)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	314	Target Neighborhood Hits	819	Shared Neighborhood Hits	50
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

NEK9_MOUSE
NC score	0.052753 (rank : 807)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	314	Target Neighborhood Hits	890	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

DAPK3_MOUSE
NC score	0.052749 (rank : 808)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	53
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

CDK2_HUMAN
NC score	0.052723 (rank : 809)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

PKN2_HUMAN
NC score	0.052717 (rank : 810)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	314	Target Neighborhood Hits	892	Shared Neighborhood Hits	51
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

MK01_HUMAN
NC score	0.052701 (rank : 811)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	314	Target Neighborhood Hits	836	Shared Neighborhood Hits	50
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

PCTK3_MOUSE
NC score	0.052638 (rank : 812)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	314	Target Neighborhood Hits	834	Shared Neighborhood Hits	50
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

STK6_HUMAN
NC score	0.052570 (rank : 813)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	314	Target Neighborhood Hits	916	Shared Neighborhood Hits	52
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

TLK2_HUMAN
NC score	0.052561 (rank : 814)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	314	Target Neighborhood Hits	1044	Shared Neighborhood Hits	53
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

PKN2_MOUSE
NC score	0.052557 (rank : 815)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	314	Target Neighborhood Hits	899	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PCTK3_HUMAN
NC score	0.052551 (rank : 816)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	314	Target Neighborhood Hits	827	Shared Neighborhood Hits	50
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

KC1AL_HUMAN
NC score	0.052486 (rank : 817)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	314	Target Neighborhood Hits	734	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

M3K1_MOUSE
NC score	0.052463 (rank : 818)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	314	Target Neighborhood Hits	952	Shared Neighborhood Hits	53
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

CDK2_MOUSE
NC score	0.052457 (rank : 819)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	314	Target Neighborhood Hits	828	Shared Neighborhood Hits	50
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

M3K2_MOUSE
NC score	0.052446 (rank : 820)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	314	Target Neighborhood Hits	846	Shared Neighborhood Hits	51
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MYO3A_HUMAN
NC score	0.052434 (rank : 821)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	314	Target Neighborhood Hits	1033	Shared Neighborhood Hits	54
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

TSSK1_HUMAN
NC score	0.052411 (rank : 822)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	314	Target Neighborhood Hits	840	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KPCE_HUMAN
NC score	0.052402 (rank : 823)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	314	Target Neighborhood Hits	906	Shared Neighborhood Hits	64
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

INADL_MOUSE
NC score	0.052293 (rank : 824)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	314	Target Neighborhood Hits	290	Shared Neighborhood Hits	28
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

PLCD1_HUMAN
NC score	0.052240 (rank : 825)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	314	Target Neighborhood Hits	93	Shared Neighborhood Hits	5
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

MK12_HUMAN
NC score	0.052171 (rank : 826)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	314	Target Neighborhood Hits	830	Shared Neighborhood Hits	51
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
NC score	0.052098 (rank : 827)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	314	Target Neighborhood Hits	835	Shared Neighborhood Hits	51
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

TLK2_MOUSE
NC score	0.052043 (rank : 828)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	314	Target Neighborhood Hits	1088	Shared Neighborhood Hits	55
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

PAK7_HUMAN
NC score	0.051971 (rank : 829)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	314	Target Neighborhood Hits	875	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK2_MOUSE
NC score	0.051915 (rank : 830)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	314	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

SNRK_MOUSE
NC score	0.051894 (rank : 831)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	314	Target Neighborhood Hits	849	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

PAK2_HUMAN
NC score	0.051892 (rank : 832)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	314	Target Neighborhood Hits	862	Shared Neighborhood Hits	50
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

CDK6_MOUSE
NC score	0.051876 (rank : 833)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

HIPK4_HUMAN
NC score	0.051849 (rank : 834)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	314	Target Neighborhood Hits	799	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

PAK7_MOUSE
NC score	0.051746 (rank : 835)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	314	Target Neighborhood Hits	875	Shared Neighborhood Hits	50
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PAK6_HUMAN
NC score	0.051631 (rank : 836)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	314	Target Neighborhood Hits	915	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

MYO3A_MOUSE
NC score	0.051545 (rank : 837)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	314	Target Neighborhood Hits	902	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

INADL_HUMAN
NC score	0.051516 (rank : 838)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	314	Target Neighborhood Hits	260	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

CDKL2_HUMAN
NC score	0.051504 (rank : 839)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

M3K4_HUMAN
NC score	0.051493 (rank : 840)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	314	Target Neighborhood Hits	911	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K6_HUMAN
NC score	0.051489 (rank : 841)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	314	Target Neighborhood Hits	889	Shared Neighborhood Hits	50
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

SLK_HUMAN
NC score	0.051397 (rank : 842)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	314	Target Neighborhood Hits	1775	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

MK03_MOUSE
NC score	0.051390 (rank : 843)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	314	Target Neighborhood Hits	840	Shared Neighborhood Hits	50
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK11_MOUSE
NC score	0.051330 (rank : 844)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	314	Target Neighborhood Hits	835	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

SNRK_HUMAN
NC score	0.051298 (rank : 845)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	314	Target Neighborhood Hits	855	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

MK03_HUMAN
NC score	0.051298 (rank : 846)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

BMP2K_HUMAN
NC score	0.051282 (rank : 847)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	314	Target Neighborhood Hits	867	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

PLK4_MOUSE
NC score	0.051226 (rank : 848)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	314	Target Neighborhood Hits	879	Shared Neighborhood Hits	50
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PIM1_MOUSE
NC score	0.051222 (rank : 849)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	314	Target Neighborhood Hits	787	Shared Neighborhood Hits	49
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

MK06_HUMAN
NC score	0.051199 (rank : 850)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	314	Target Neighborhood Hits	815	Shared Neighborhood Hits	49
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

PLK4_HUMAN
NC score	0.051184 (rank : 851)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	314	Target Neighborhood Hits	884	Shared Neighborhood Hits	50
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PAR6B_MOUSE
NC score	0.051140 (rank : 852)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	314	Target Neighborhood Hits	128	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAK4_MOUSE
NC score	0.051111 (rank : 853)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	314	Target Neighborhood Hits	1098	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

GAK_HUMAN
NC score	0.051102 (rank : 854)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	314	Target Neighborhood Hits	1028	Shared Neighborhood Hits	59
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

ST17B_MOUSE
NC score	0.051060 (rank : 855)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	314	Target Neighborhood Hits	838	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MELK_MOUSE
NC score	0.051022 (rank : 856)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	314	Target Neighborhood Hits	860	Shared Neighborhood Hits	50
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

CDKL2_MOUSE
NC score	0.051001 (rank : 857)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	314	Target Neighborhood Hits	854	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

MK06_MOUSE
NC score	0.050978 (rank : 858)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	314	Target Neighborhood Hits	818	Shared Neighborhood Hits	49
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

STK33_HUMAN
NC score	0.050960 (rank : 859)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	314	Target Neighborhood Hits	879	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

PKN1_MOUSE
NC score	0.050908 (rank : 860)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	314	Target Neighborhood Hits	888	Shared Neighborhood Hits	51
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

STK6_MOUSE
NC score	0.050875 (rank : 861)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

USH1C_MOUSE
NC score	0.050857 (rank : 862)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	314	Target Neighborhood Hits	557	Shared Neighborhood Hits	37
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

CDK6_HUMAN
NC score	0.050823 (rank : 863)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	314	Target Neighborhood Hits	837	Shared Neighborhood Hits	50
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

PAR6B_HUMAN
NC score	0.050812 (rank : 864)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	314	Target Neighborhood Hits	126	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

DAPK2_HUMAN
NC score	0.050806 (rank : 865)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	314	Target Neighborhood Hits	832	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MELK_HUMAN
NC score	0.050727 (rank : 866)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	314	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

DAPK2_MOUSE
NC score	0.050713 (rank : 867)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	314	Target Neighborhood Hits	834	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

PKN1_HUMAN
NC score	0.050694 (rank : 868)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	314	Target Neighborhood Hits	886	Shared Neighborhood Hits	52
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

APBA3_HUMAN
NC score	0.050688 (rank : 869)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	314	Target Neighborhood Hits	201	Shared Neighborhood Hits	35
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

M3K4_MOUSE
NC score	0.050683 (rank : 870)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	314	Target Neighborhood Hits	924	Shared Neighborhood Hits	51
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

MASTL_MOUSE
NC score	0.050660 (rank : 871)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	314	Target Neighborhood Hits	862	Shared Neighborhood Hits	50
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

NRK_MOUSE
NC score	0.050608 (rank : 872)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	314	Target Neighborhood Hits	899	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

SYJ2B_HUMAN
NC score	0.050604 (rank : 873)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	314	Target Neighborhood Hits	162	Shared Neighborhood Hits	12
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

STK35_HUMAN
NC score	0.050586 (rank : 874)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	314	Target Neighborhood Hits	825	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

CHK1_HUMAN
NC score	0.050566 (rank : 875)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	314	Target Neighborhood Hits	843	Shared Neighborhood Hits	51
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

UHMK1_MOUSE
NC score	0.050533 (rank : 876)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	314	Target Neighborhood Hits	809	Shared Neighborhood Hits	47
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

DAPK1_MOUSE
NC score	0.050444 (rank : 877)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	314	Target Neighborhood Hits	1138	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

KC1A_HUMAN
NC score	0.050419 (rank : 878)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	314	Target Neighborhood Hits	728	Shared Neighborhood Hits	47
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.050419 (rank : 879)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	314	Target Neighborhood Hits	728	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

M4K3_HUMAN
NC score	0.050407 (rank : 880)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	314	Target Neighborhood Hits	857	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

ST17B_HUMAN
NC score	0.050391 (rank : 881)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

LMO7_HUMAN
NC score	0.050344 (rank : 882)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	314	Target Neighborhood Hits	507	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

S3TC1_HUMAN
NC score	0.050333 (rank : 883)	θ value	5.27518 (rank : 300)
Query Neighborhood Hits	314	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

NRK_HUMAN
NC score	0.050265 (rank : 884)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	314	Target Neighborhood Hits	931	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

SLK_MOUSE
NC score	0.050243 (rank : 885)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	314	Target Neighborhood Hits	1798	Shared Neighborhood Hits	66
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

KS6A3_MOUSE
NC score	0.050240 (rank : 886)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	314	Target Neighborhood Hits	860	Shared Neighborhood Hits	50
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

FGD6_HUMAN
NC score	0.050236 (rank : 887)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	314	Target Neighborhood Hits	237	Shared Neighborhood Hits	22
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

KS6A3_HUMAN
NC score	0.050233 (rank : 888)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	314	Target Neighborhood Hits	859	Shared Neighborhood Hits	50
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

AURKC_MOUSE
NC score	0.050204 (rank : 889)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	314	Target Neighborhood Hits	844	Shared Neighborhood Hits	50
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

PAR3L_HUMAN
NC score	0.050115 (rank : 890)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	314	Target Neighborhood Hits	297	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

CDKL4_MOUSE
NC score	0.050108 (rank : 891)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	314	Target Neighborhood Hits	833	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

M4K5_HUMAN
NC score	0.050077 (rank : 892)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	314	Target Neighborhood Hits	845	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

PAK1_HUMAN
NC score	0.050072 (rank : 893)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	314	Target Neighborhood Hits	873	Shared Neighborhood Hits	51
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

CHK1_MOUSE
NC score	0.050054 (rank : 894)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	314	Target Neighborhood Hits	839	Shared Neighborhood Hits	50
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

M4K5_MOUSE
NC score	0.050021 (rank : 895)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	314	Target Neighborhood Hits	839	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

CSKI2_MOUSE
NC score	0.049362 (rank : 896)	θ value	0.0736092 (rank : 222)
Query Neighborhood Hits	314	Target Neighborhood Hits	812	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

RIN2_MOUSE
NC score	0.038447 (rank : 897)	θ value	5.27518 (rank : 299)
Query Neighborhood Hits	314	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D684, Q99K06	Gene names	Rin2
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2).

CSKI1_MOUSE
NC score	0.035112 (rank : 898)	θ value	6.88961 (rank : 304)
Query Neighborhood Hits	314	Target Neighborhood Hits	1031	Shared Neighborhood Hits	67
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.034192 (rank : 899)	θ value	6.88961 (rank : 303)
Query Neighborhood Hits	314	Target Neighborhood Hits	997	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SART3_MOUSE
NC score	0.017194 (rank : 900)	θ value	0.21417 (rank : 252)
Query Neighborhood Hits	314	Target Neighborhood Hits	341	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLI8, Q6ZQI2, Q8BPK9, Q8C3B7, Q8CFU9	Gene names	Sart3, Kiaa0156
Domain Architecture	No domain graphic available
Description	Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (mSART-3) (Tumor-rejection antigen SART3).

BSPRY_MOUSE
NC score	0.013537 (rank : 901)	θ value	0.21417 (rank : 246)
Query Neighborhood Hits	314	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

ARI1A_HUMAN
NC score	0.012961 (rank : 902)	θ value	3.0926 (rank : 289)
Query Neighborhood Hits	314	Target Neighborhood Hits	787	Shared Neighborhood Hits	29
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

SPAG8_HUMAN
NC score	0.012405 (rank : 903)	θ value	8.99809 (rank : 313)
Query Neighborhood Hits	314	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	Q99932, Q12937, Q5TCV8, Q8WWB4	Gene names	SPAG8
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 8 (Sperm membrane protein 1) (SMP-1) (HSD-1) (Sperm membrane protein BS-84).

TRI66_MOUSE
NC score	0.009241 (rank : 904)	θ value	8.99809 (rank : 314)
Query Neighborhood Hits	314	Target Neighborhood Hits	491	Shared Neighborhood Hits	12
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

TAF6_HUMAN
NC score	0.008973 (rank : 905)	θ value	5.27518 (rank : 302)
Query Neighborhood Hits	314	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

NCOR2_MOUSE
NC score	0.008911 (rank : 906)	θ value	6.88961 (rank : 305)
Query Neighborhood Hits	314	Target Neighborhood Hits	790	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

ATN1_HUMAN
NC score	0.008466 (rank : 907)	θ value	8.99809 (rank : 310)
Query Neighborhood Hits	314	Target Neighborhood Hits	676	Shared Neighborhood Hits	23
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BAT3_HUMAN
NC score	0.007678 (rank : 908)	θ value	5.27518 (rank : 296)
Query Neighborhood Hits	314	Target Neighborhood Hits	490	Shared Neighborhood Hits	12
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

NOTC2_HUMAN
NC score	0.000794 (rank : 909)	θ value	0.813845 (rank : 271)
Query Neighborhood Hits	314	Target Neighborhood Hits	1113	Shared Neighborhood Hits	22
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

TIF1G_HUMAN
NC score	0.000404 (rank : 910)	θ value	6.88961 (rank : 307)
Query Neighborhood Hits	314	Target Neighborhood Hits	410	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).