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Network neighborhood for query Sequence : SAMN1_HUMAN

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SAMN1_HUMAN
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SAMN1_HUMAN
θ value	1.90928e-167 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	4.00889e-141 (rank : 2)	NC score	0.989030 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	51
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SLY_HUMAN
θ value	6.55044e-59 (rank : 3)	NC score	0.933333 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	2.32979e-56 (rank : 4)	NC score	0.922484 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	108	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SASH1_HUMAN
θ value	1.67352e-46 (rank : 5)	NC score	0.820252 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	292	Shared Neighborhood Hits	52
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	3.48949e-44 (rank : 6)	NC score	0.816015 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	263	Shared Neighborhood Hits	53
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ANKS1_HUMAN
θ value	9.29e-05 (rank : 7)	NC score	0.138881 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	438	Shared Neighborhood Hits	17
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	0.000121331 (rank : 8)	NC score	0.145144 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	453	Shared Neighborhood Hits	19
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

MYO1E_HUMAN
θ value	0.00134147 (rank : 9)	NC score	0.094409 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	293	Shared Neighborhood Hits	43
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

CD2AP_HUMAN
θ value	0.00175202 (rank : 10)	NC score	0.212584 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	315	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ARHG6_HUMAN
θ value	0.00509761 (rank : 11)	NC score	0.167337 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	376	Shared Neighborhood Hits	45
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CRK_MOUSE
θ value	0.0113563 (rank : 12)	NC score	0.196074 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	314	Shared Neighborhood Hits	45
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
θ value	0.0252991 (rank : 13)	NC score	0.188947 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	308	Shared Neighborhood Hits	46
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ARHG7_HUMAN
θ value	0.0431538 (rank : 14)	NC score	0.156368 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	347	Shared Neighborhood Hits	44
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ZBED4_HUMAN
θ value	0.0431538 (rank : 15)	NC score	0.074416 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	O75132, Q9UGG8	Gene names	ZBED4, KIAA0637
Domain Architecture
Description	Zinc finger BED domain-containing protein 4.

ARHG6_MOUSE
θ value	0.0563607 (rank : 16)	NC score	0.161408 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	394	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_MOUSE
θ value	0.125558 (rank : 17)	NC score	0.153295 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	396	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CRKL_HUMAN
θ value	0.125558 (rank : 18)	NC score	0.180413 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	313	Shared Neighborhood Hits	46
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	0.125558 (rank : 19)	NC score	0.180252 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CSKI1_HUMAN
θ value	0.125558 (rank : 20)	NC score	0.087491 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	997	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	0.125558 (rank : 21)	NC score	0.088368 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	1031	Shared Neighborhood Hits	41
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

M3K9_HUMAN
θ value	0.21417 (rank : 22)	NC score	0.036132 (rank : 109)
Query Neighborhood Hits	74	Target Neighborhood Hits	1123	Shared Neighborhood Hits	47
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

EPHA2_MOUSE
θ value	0.279714 (rank : 23)	NC score	0.025434 (rank : 113)
Query Neighborhood Hits	74	Target Neighborhood Hits	1020	Shared Neighborhood Hits	20
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

GRAP2_MOUSE
θ value	0.279714 (rank : 24)	NC score	0.115633 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	297	Shared Neighborhood Hits	44
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

WDR60_HUMAN
θ value	0.279714 (rank : 25)	NC score	0.039464 (rank : 108)
Query Neighborhood Hits	74	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WVS4, Q9NW58	Gene names	WDR60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

MYO1F_HUMAN
θ value	0.365318 (rank : 26)	NC score	0.076455 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	275	Shared Neighborhood Hits	45
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

STAM1_HUMAN
θ value	0.365318 (rank : 27)	NC score	0.091385 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	271	Shared Neighborhood Hits	42
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

VAV_HUMAN
θ value	0.365318 (rank : 28)	NC score	0.116679 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	452	Shared Neighborhood Hits	42
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CASQ1_MOUSE
θ value	0.47712 (rank : 29)	NC score	0.040954 (rank : 106)
Query Neighborhood Hits	74	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	O09165	Gene names	Casq1
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform).

NCK2_HUMAN
θ value	0.47712 (rank : 30)	NC score	0.120392 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

VAV_MOUSE
θ value	0.47712 (rank : 31)	NC score	0.116549 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	430	Shared Neighborhood Hits	42
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

EPHA2_HUMAN
θ value	0.62314 (rank : 32)	NC score	0.023724 (rank : 115)
Query Neighborhood Hits	74	Target Neighborhood Hits	1021	Shared Neighborhood Hits	21
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

GRAP2_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.107343 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	304	Shared Neighborhood Hits	44
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CEND1_HUMAN
θ value	0.813845 (rank : 34)	NC score	0.048871 (rank : 105)
Query Neighborhood Hits	74	Target Neighborhood Hits	284	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

EPHA1_HUMAN
θ value	1.06291 (rank : 35)	NC score	0.021220 (rank : 119)
Query Neighborhood Hits	74	Target Neighborhood Hits	997	Shared Neighborhood Hits	18
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

GRAP_HUMAN
θ value	1.06291 (rank : 36)	NC score	0.134482 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

MDN1_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.029398 (rank : 111)
Query Neighborhood Hits	74	Target Neighborhood Hits	662	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

SH3K1_MOUSE
θ value	1.06291 (rank : 38)	NC score	0.170991 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	332	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

AP3B2_MOUSE
θ value	1.38821 (rank : 39)	NC score	0.021777 (rank : 118)
Query Neighborhood Hits	74	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

ITSN1_HUMAN
θ value	1.38821 (rank : 40)	NC score	0.083098 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	1757	Shared Neighborhood Hits	53
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3K1_HUMAN
θ value	1.38821 (rank : 41)	NC score	0.172335 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	341	Shared Neighborhood Hits	46
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

STAC_MOUSE
θ value	1.38821 (rank : 42)	NC score	0.115159 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	268	Shared Neighborhood Hits	46
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CCD46_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.007853 (rank : 128)
Query Neighborhood Hits	74	Target Neighborhood Hits	1430	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CEND1_MOUSE
θ value	1.81305 (rank : 44)	NC score	0.039726 (rank : 107)
Query Neighborhood Hits	74	Target Neighborhood Hits	260	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CSKI2_MOUSE
θ value	1.81305 (rank : 45)	NC score	0.077000 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	812	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

VAV3_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.102538 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	398	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CASQ1_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.035152 (rank : 110)
Query Neighborhood Hits	74	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	P31415, Q8TBW7	Gene names	CASQ1, CASQ
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform) (Calmitin).

CSKI2_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.074002 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	747	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA1_MOUSE
θ value	2.36792 (rank : 49)	NC score	0.021919 (rank : 117)
Query Neighborhood Hits	74	Target Neighborhood Hits	958	Shared Neighborhood Hits	18
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

LAMA3_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.012956 (rank : 123)
Query Neighborhood Hits	74	Target Neighborhood Hits	859	Shared Neighborhood Hits	11
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

SET1A_HUMAN
θ value	2.36792 (rank : 51)	NC score	0.028473 (rank : 112)
Query Neighborhood Hits	74	Target Neighborhood Hits	690	Shared Neighborhood Hits	5
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SH3G3_MOUSE
θ value	2.36792 (rank : 52)	NC score	0.111708 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRBS1_HUMAN
θ value	2.36792 (rank : 53)	NC score	0.108713 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	396	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP_MOUSE
θ value	3.0926 (rank : 54)	NC score	0.123251 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	309	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

MYO1F_MOUSE
θ value	3.0926 (rank : 55)	NC score	0.061356 (rank : 85)
Query Neighborhood Hits	74	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

RBM19_MOUSE
θ value	3.0926 (rank : 56)	NC score	0.009771 (rank : 126)
Query Neighborhood Hits	74	Target Neighborhood Hits	296	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R3C6, Q8BHR0, Q9CW63	Gene names	Rbm19
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 19 (RNA-binding motif protein 19).

STAC_HUMAN
θ value	3.0926 (rank : 57)	NC score	0.114688 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	276	Shared Neighborhood Hits	46
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VAV3_MOUSE
θ value	3.0926 (rank : 58)	NC score	0.100251 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	404	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ABL1_MOUSE
θ value	4.03905 (rank : 59)	NC score	0.023096 (rank : 116)
Query Neighborhood Hits	74	Target Neighborhood Hits	1178	Shared Neighborhood Hits	36
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CENPE_HUMAN
θ value	4.03905 (rank : 60)	NC score	0.005145 (rank : 131)
Query Neighborhood Hits	74	Target Neighborhood Hits	2060	Shared Neighborhood Hits	19
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CHRC1_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.024979 (rank : 114)
Query Neighborhood Hits	74	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRG0	Gene names	CHRAC1, CHRAC15
Domain Architecture
Description	Chromatin accessibility complex protein 1 (CHRAC-1) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15).

SFR16_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.021204 (rank : 120)
Query Neighborhood Hits	74	Target Neighborhood Hits	177	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

AP3B2_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.019363 (rank : 122)
Query Neighborhood Hits	74	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

CD2AP_MOUSE
θ value	5.27518 (rank : 64)	NC score	0.162595 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	336	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ITSN1_MOUSE
θ value	5.27518 (rank : 65)	NC score	0.074522 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	1669	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

APC_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.020373 (rank : 121)
Query Neighborhood Hits	74	Target Neighborhood Hits	603	Shared Neighborhood Hits	12
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

CN092_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.010197 (rank : 124)
Query Neighborhood Hits	74	Target Neighborhood Hits	206	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

ITSN2_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.071921 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	1173	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SH3G3_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.078794 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	222	Shared Neighborhood Hits	37
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ARMX1_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.007045 (rank : 129)
Query Neighborhood Hits	74	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX83	Gene names	Armcx1
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 1.

CN155_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.009815 (rank : 125)
Query Neighborhood Hits	74	Target Neighborhood Hits	385	Shared Neighborhood Hits	7
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

PVRL1_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.005897 (rank : 130)
Query Neighborhood Hits	74	Target Neighborhood Hits	201	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

SH3G2_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.097925 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	319	Shared Neighborhood Hits	41
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

TTC3_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.009294 (rank : 127)
Query Neighborhood Hits	74	Target Neighborhood Hits	664	Shared Neighborhood Hits	7
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

ABI1_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.058139 (rank : 93)
Query Neighborhood Hits	74	Target Neighborhood Hits	257	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.060623 (rank : 87)
Query Neighborhood Hits	74	Target Neighborhood Hits	246	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.084026 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.086116 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	266	Shared Neighborhood Hits	40
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.059122 (rank : 89)
Query Neighborhood Hits	74	Target Neighborhood Hits	227	Shared Neighborhood Hits	37
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.051453 (rank : 104)
Query Neighborhood Hits	74	Target Neighborhood Hits	227	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG4_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.065075 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	242	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.065057 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	185	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.059481 (rank : 88)
Query Neighborhood Hits	74	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.058764 (rank : 91)
Query Neighborhood Hits	74	Target Neighborhood Hits	234	Shared Neighborhood Hits	36
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CT032_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.059067 (rank : 90)
Query Neighborhood Hits	74	Target Neighborhood Hits	235	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.057648 (rank : 97)
Query Neighborhood Hits	74	Target Neighborhood Hits	244	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.057751 (rank : 95)
Query Neighborhood Hits	74	Target Neighborhood Hits	306	Shared Neighborhood Hits	38
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DNMBP_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.070955 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	413	Shared Neighborhood Hits	38
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.070711 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	435	Shared Neighborhood Hits	38
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRB2_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.083547 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.083438 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	312	Shared Neighborhood Hits	38
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.071426 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	358	Shared Neighborhood Hits	38
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.065537 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ITSN2_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.066977 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	1371	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NCF1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.076831 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.076953 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.083167 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	229	Shared Neighborhood Hits	36
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.063713 (rank : 80)
Query Neighborhood Hits	74	Target Neighborhood Hits	161	Shared Neighborhood Hits	33
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.067116 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.089773 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	312	Shared Neighborhood Hits	39
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NOXO1_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.055200 (rank : 98)
Query Neighborhood Hits	74	Target Neighborhood Hits	114	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.058279 (rank : 92)
Query Neighborhood Hits	74	Target Neighborhood Hits	288	Shared Neighborhood Hits	37
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.075264 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	267	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.084301 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	466	Shared Neighborhood Hits	44
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.085384 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	467	Shared Neighborhood Hits	44
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN1_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.054590 (rank : 99)
Query Neighborhood Hits	74	Target Neighborhood Hits	320	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.054359 (rank : 100)
Query Neighborhood Hits	74	Target Neighborhood Hits	283	Shared Neighborhood Hits	38
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.058063 (rank : 94)
Query Neighborhood Hits	74	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.057749 (rank : 96)
Query Neighborhood Hits	74	Target Neighborhood Hits	382	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.052488 (rank : 103)
Query Neighborhood Hits	74	Target Neighborhood Hits	385	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.052524 (rank : 102)
Query Neighborhood Hits	74	Target Neighborhood Hits	380	Shared Neighborhood Hits	38
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PLCG1_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.061295 (rank : 86)
Query Neighborhood Hits	74	Target Neighborhood Hits	293	Shared Neighborhood Hits	35
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.061692 (rank : 84)
Query Neighborhood Hits	74	Target Neighborhood Hits	314	Shared Neighborhood Hits	36
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.053982 (rank : 101)
Query Neighborhood Hits	74	Target Neighborhood Hits	280	Shared Neighborhood Hits	36
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.063807 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	389	Shared Neighborhood Hits	38
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.062646 (rank : 82)
Query Neighborhood Hits	74	Target Neighborhood Hits	377	Shared Neighborhood Hits	37
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SH3G1_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.076223 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.080710 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	291	Shared Neighborhood Hits	39
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.084184 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	324	Shared Neighborhood Hits	37
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SRBS1_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.094992 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	409	Shared Neighborhood Hits	41
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.063206 (rank : 81)
Query Neighborhood Hits	74	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.062064 (rank : 83)
Query Neighborhood Hits	74	Target Neighborhood Hits	292	Shared Neighborhood Hits	36
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.070058 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.070778 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	232	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.075025 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	273	Shared Neighborhood Hits	40
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.071196 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	288	Shared Neighborhood Hits	39
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.072491 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	285	Shared Neighborhood Hits	41
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VAV2_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.086111 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	453	Shared Neighborhood Hits	41
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.084241 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	456	Shared Neighborhood Hits	41
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VINEX_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.100113 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	270	Shared Neighborhood Hits	39
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.096418 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	286	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

SAMN1_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.90928e-167 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
NC score	0.989030 (rank : 2)	θ value	4.00889e-141 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	51
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SLY_HUMAN
NC score	0.933333 (rank : 3)	θ value	6.55044e-59 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
NC score	0.922484 (rank : 4)	θ value	2.32979e-56 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	108	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SASH1_HUMAN
NC score	0.820252 (rank : 5)	θ value	1.67352e-46 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	292	Shared Neighborhood Hits	52
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
NC score	0.816015 (rank : 6)	θ value	3.48949e-44 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	263	Shared Neighborhood Hits	53
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CD2AP_HUMAN
NC score	0.212584 (rank : 7)	θ value	0.00175202 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	315	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CRK_MOUSE
NC score	0.196074 (rank : 8)	θ value	0.0113563 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	314	Shared Neighborhood Hits	45
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.188947 (rank : 9)	θ value	0.0252991 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	308	Shared Neighborhood Hits	46
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
NC score	0.180413 (rank : 10)	θ value	0.125558 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	313	Shared Neighborhood Hits	46
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.180252 (rank : 11)	θ value	0.125558 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH3K1_HUMAN
NC score	0.172335 (rank : 12)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	341	Shared Neighborhood Hits	46
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.170991 (rank : 13)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	332	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ARHG6_HUMAN
NC score	0.167337 (rank : 14)	θ value	0.00509761 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	376	Shared Neighborhood Hits	45
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CD2AP_MOUSE
NC score	0.162595 (rank : 15)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	336	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ARHG6_MOUSE
NC score	0.161408 (rank : 16)	θ value	0.0563607 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	394	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
NC score	0.156368 (rank : 17)	θ value	0.0431538 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	347	Shared Neighborhood Hits	44
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.153295 (rank : 18)	θ value	0.125558 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	396	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ANKS1_MOUSE
NC score	0.145144 (rank : 19)	θ value	0.000121331 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	453	Shared Neighborhood Hits	19
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANKS1_HUMAN
NC score	0.138881 (rank : 20)	θ value	9.29e-05 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	438	Shared Neighborhood Hits	17
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

GRAP_HUMAN
NC score	0.134482 (rank : 21)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.123251 (rank : 22)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	309	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.120392 (rank : 23)	θ value	0.47712 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

VAV_HUMAN
NC score	0.116679 (rank : 24)	θ value	0.365318 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	452	Shared Neighborhood Hits	42
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.116549 (rank : 25)	θ value	0.47712 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	430	Shared Neighborhood Hits	42
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GRAP2_MOUSE
NC score	0.115633 (rank : 26)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	297	Shared Neighborhood Hits	44
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAC_MOUSE
NC score	0.115159 (rank : 27)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	268	Shared Neighborhood Hits	46
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_HUMAN
NC score	0.114688 (rank : 28)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	276	Shared Neighborhood Hits	46
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SH3G3_MOUSE
NC score	0.111708 (rank : 29)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRBS1_HUMAN
NC score	0.108713 (rank : 30)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	396	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP2_HUMAN
NC score	0.107343 (rank : 31)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	304	Shared Neighborhood Hits	44
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

VAV3_HUMAN
NC score	0.102538 (rank : 32)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	398	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.100251 (rank : 33)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	404	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VINEX_HUMAN
NC score	0.100113 (rank : 34)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	74	Target Neighborhood Hits	270	Shared Neighborhood Hits	39
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SH3G2_MOUSE
NC score	0.097925 (rank : 35)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	319	Shared Neighborhood Hits	41
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

VINEX_MOUSE
NC score	0.096418 (rank : 36)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	74	Target Neighborhood Hits	286	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRBS1_MOUSE
NC score	0.094992 (rank : 37)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	74	Target Neighborhood Hits	409	Shared Neighborhood Hits	41
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MYO1E_HUMAN
NC score	0.094409 (rank : 38)	θ value	0.00134147 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	293	Shared Neighborhood Hits	43
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

STAM1_HUMAN
NC score	0.091385 (rank : 39)	θ value	0.365318 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	271	Shared Neighborhood Hits	42
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCK1_HUMAN
NC score	0.089773 (rank : 40)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	74	Target Neighborhood Hits	312	Shared Neighborhood Hits	39
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CSKI1_MOUSE
NC score	0.088368 (rank : 41)	θ value	0.125558 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	1031	Shared Neighborhood Hits	41
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.087491 (rank : 42)	θ value	0.125558 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	997	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ABI2_MOUSE
NC score	0.086116 (rank : 43)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	266	Shared Neighborhood Hits	40
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

VAV2_HUMAN
NC score	0.086111 (rank : 44)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	74	Target Neighborhood Hits	453	Shared Neighborhood Hits	41
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

OSTF1_MOUSE
NC score	0.085384 (rank : 45)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	74	Target Neighborhood Hits	467	Shared Neighborhood Hits	44
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OSTF1_HUMAN
NC score	0.084301 (rank : 46)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	74	Target Neighborhood Hits	466	Shared Neighborhood Hits	44
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

VAV2_MOUSE
NC score	0.084241 (rank : 47)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	74	Target Neighborhood Hits	456	Shared Neighborhood Hits	41
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

SH3G2_HUMAN
NC score	0.084184 (rank : 48)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	74	Target Neighborhood Hits	324	Shared Neighborhood Hits	37
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ABI2_HUMAN
NC score	0.084026 (rank : 49)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

GRB2_HUMAN
NC score	0.083547 (rank : 50)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	74	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.083438 (rank : 51)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	74	Target Neighborhood Hits	312	Shared Neighborhood Hits	38
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF2_HUMAN
NC score	0.083167 (rank : 52)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	74	Target Neighborhood Hits	229	Shared Neighborhood Hits	36
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ITSN1_HUMAN
NC score	0.083098 (rank : 53)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	1757	Shared Neighborhood Hits	53
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3G1_MOUSE
NC score	0.080710 (rank : 54)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	74	Target Neighborhood Hits	291	Shared Neighborhood Hits	39
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
NC score	0.078794 (rank : 55)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	222	Shared Neighborhood Hits	37
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CSKI2_MOUSE
NC score	0.077000 (rank : 56)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	812	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

NCF1_MOUSE
NC score	0.076953 (rank : 57)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF1_HUMAN
NC score	0.076831 (rank : 58)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

MYO1F_HUMAN
NC score	0.076455 (rank : 59)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	275	Shared Neighborhood Hits	45
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SH3G1_HUMAN
NC score	0.076223 (rank : 60)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	74	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

NPHP1_MOUSE
NC score	0.075264 (rank : 61)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	74	Target Neighborhood Hits	267	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STAM1_MOUSE
NC score	0.075025 (rank : 62)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	74	Target Neighborhood Hits	273	Shared Neighborhood Hits	40
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ITSN1_MOUSE
NC score	0.074522 (rank : 63)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	1669	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ZBED4_HUMAN
NC score	0.074416 (rank : 64)	θ value	0.0431538 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	O75132, Q9UGG8	Gene names	ZBED4, KIAA0637
Domain Architecture
Description	Zinc finger BED domain-containing protein 4.

CSKI2_HUMAN
NC score	0.074002 (rank : 65)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	747	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

STAM2_MOUSE
NC score	0.072491 (rank : 66)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	74	Target Neighborhood Hits	285	Shared Neighborhood Hits	41
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ITSN2_HUMAN
NC score	0.071921 (rank : 67)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	1173	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

HCLS1_HUMAN
NC score	0.071426 (rank : 68)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	74	Target Neighborhood Hits	358	Shared Neighborhood Hits	38
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

STAM2_HUMAN
NC score	0.071196 (rank : 69)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	74	Target Neighborhood Hits	288	Shared Neighborhood Hits	39
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

DNMBP_HUMAN
NC score	0.070955 (rank : 70)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	74	Target Neighborhood Hits	413	Shared Neighborhood Hits	38
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAC3_MOUSE
NC score	0.070778 (rank : 71)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	74	Target Neighborhood Hits	232	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

DNMBP_MOUSE
NC score	0.070711 (rank : 72)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	74	Target Neighborhood Hits	435	Shared Neighborhood Hits	38
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAC3_HUMAN
NC score	0.070058 (rank : 73)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	74	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCF4_MOUSE
NC score	0.067116 (rank : 74)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	74	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ITSN2_MOUSE
NC score	0.066977 (rank : 75)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	74	Target Neighborhood Hits	1371	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

HCLS1_MOUSE
NC score	0.065537 (rank : 76)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	74	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ARHG4_HUMAN
NC score	0.065075 (rank : 77)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	74	Target Neighborhood Hits	242	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
NC score	0.065057 (rank : 78)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	74	Target Neighborhood Hits	185	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PPIP1_HUMAN
NC score	0.063807 (rank : 79)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	74	Target Neighborhood Hits	389	Shared Neighborhood Hits	38
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

NCF4_HUMAN
NC score	0.063713 (rank : 80)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	74	Target Neighborhood Hits	161	Shared Neighborhood Hits	33
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SRC8_HUMAN
NC score	0.063206 (rank : 81)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	74	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

PPIP1_MOUSE
NC score	0.062646 (rank : 82)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	74	Target Neighborhood Hits	377	Shared Neighborhood Hits	37
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SRC8_MOUSE
NC score	0.062064 (rank : 83)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	74	Target Neighborhood Hits	292	Shared Neighborhood Hits	36
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PLCG1_MOUSE
NC score	0.061692 (rank : 84)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	74	Target Neighborhood Hits	314	Shared Neighborhood Hits	36
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MYO1F_MOUSE
NC score	0.061356 (rank : 85)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PLCG1_HUMAN
NC score	0.061295 (rank : 86)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	74	Target Neighborhood Hits	293	Shared Neighborhood Hits	35
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ABI1_MOUSE
NC score	0.060623 (rank : 87)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	246	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ARHG9_HUMAN
NC score	0.059481 (rank : 88)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	74	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ABI3_HUMAN
NC score	0.059122 (rank : 89)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	227	Shared Neighborhood Hits	37
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CT032_HUMAN
NC score	0.059067 (rank : 90)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	74	Target Neighborhood Hits	235	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

ARHG9_MOUSE
NC score	0.058764 (rank : 91)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	74	Target Neighborhood Hits	234	Shared Neighborhood Hits	36
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

NPHP1_HUMAN
NC score	0.058279 (rank : 92)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	74	Target Neighborhood Hits	288	Shared Neighborhood Hits	37
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ABI1_HUMAN
NC score	0.058139 (rank : 93)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	257	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PACN2_HUMAN
NC score	0.058063 (rank : 94)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	74	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

DBNL_MOUSE
NC score	0.057751 (rank : 95)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	74	Target Neighborhood Hits	306	Shared Neighborhood Hits	38
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

PACN2_MOUSE
NC score	0.057749 (rank : 96)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	74	Target Neighborhood Hits	382	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

DBNL_HUMAN
NC score	0.057648 (rank : 97)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	74	Target Neighborhood Hits	244	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

NOXO1_MOUSE
NC score	0.055200 (rank : 98)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	74	Target Neighborhood Hits	114	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PACN1_HUMAN
NC score	0.054590 (rank : 99)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	74	Target Neighborhood Hits	320	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.054359 (rank : 100)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	74	Target Neighborhood Hits	283	Shared Neighborhood Hits	38
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PLCG2_HUMAN
NC score	0.053982 (rank : 101)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	74	Target Neighborhood Hits	280	Shared Neighborhood Hits	36
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PACN3_MOUSE
NC score	0.052524 (rank : 102)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	74	Target Neighborhood Hits	380	Shared Neighborhood Hits	38
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.052488 (rank : 103)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	74	Target Neighborhood Hits	385	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ABI3_MOUSE
NC score	0.051453 (rank : 104)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	74	Target Neighborhood Hits	227	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CEND1_HUMAN
NC score	0.048871 (rank : 105)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	284	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CASQ1_MOUSE
NC score	0.040954 (rank : 106)	θ value	0.47712 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	O09165	Gene names	Casq1
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform).

CEND1_MOUSE
NC score	0.039726 (rank : 107)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	260	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

WDR60_HUMAN
NC score	0.039464 (rank : 108)	θ value	0.279714 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WVS4, Q9NW58	Gene names	WDR60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

M3K9_HUMAN
NC score	0.036132 (rank : 109)	θ value	0.21417 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	1123	Shared Neighborhood Hits	47
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

CASQ1_HUMAN
NC score	0.035152 (rank : 110)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	P31415, Q8TBW7	Gene names	CASQ1, CASQ
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform) (Calmitin).

MDN1_HUMAN
NC score	0.029398 (rank : 111)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	662	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

SET1A_HUMAN
NC score	0.028473 (rank : 112)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	690	Shared Neighborhood Hits	5
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

EPHA2_MOUSE
NC score	0.025434 (rank : 113)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	1020	Shared Neighborhood Hits	20
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

CHRC1_HUMAN
NC score	0.024979 (rank : 114)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRG0	Gene names	CHRAC1, CHRAC15
Domain Architecture
Description	Chromatin accessibility complex protein 1 (CHRAC-1) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15).

EPHA2_HUMAN
NC score	0.023724 (rank : 115)	θ value	0.62314 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	1021	Shared Neighborhood Hits	21
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ABL1_MOUSE
NC score	0.023096 (rank : 116)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	1178	Shared Neighborhood Hits	36
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

EPHA1_MOUSE
NC score	0.021919 (rank : 117)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	958	Shared Neighborhood Hits	18
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

AP3B2_MOUSE
NC score	0.021777 (rank : 118)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

EPHA1_HUMAN
NC score	0.021220 (rank : 119)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	997	Shared Neighborhood Hits	18
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

SFR16_MOUSE
NC score	0.021204 (rank : 120)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	177	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

APC_HUMAN
NC score	0.020373 (rank : 121)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	603	Shared Neighborhood Hits	12
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

AP3B2_HUMAN
NC score	0.019363 (rank : 122)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

LAMA3_MOUSE
NC score	0.012956 (rank : 123)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	859	Shared Neighborhood Hits	11
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

CN092_MOUSE
NC score	0.010197 (rank : 124)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	206	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

CN155_HUMAN
NC score	0.009815 (rank : 125)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	385	Shared Neighborhood Hits	7
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

RBM19_MOUSE
NC score	0.009771 (rank : 126)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	296	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R3C6, Q8BHR0, Q9CW63	Gene names	Rbm19
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 19 (RNA-binding motif protein 19).

TTC3_HUMAN
NC score	0.009294 (rank : 127)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	664	Shared Neighborhood Hits	7
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

CCD46_HUMAN
NC score	0.007853 (rank : 128)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	1430	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

ARMX1_MOUSE
NC score	0.007045 (rank : 129)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX83	Gene names	Armcx1
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 1.

PVRL1_MOUSE
NC score	0.005897 (rank : 130)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	201	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

CENPE_HUMAN
NC score	0.005145 (rank : 131)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	2060	Shared Neighborhood Hits	19
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).