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Network neighborhood for query Sequence : SH3K1_MOUSE

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SH3K1_MOUSE
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SH3K1_HUMAN
θ value	0 (rank : 1)	NC score	0.989825 (rank : 2)
Query Neighborhood Hits	332	Target Neighborhood Hits	341	Shared Neighborhood Hits	292
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	332	Target Neighborhood Hits	332	Shared Neighborhood Hits	332
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_HUMAN
θ value	2.31901e-72 (rank : 3)	NC score	0.919308 (rank : 4)
Query Neighborhood Hits	332	Target Neighborhood Hits	315	Shared Neighborhood Hits	217
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	2.31901e-72 (rank : 4)	NC score	0.922282 (rank : 3)
Query Neighborhood Hits	332	Target Neighborhood Hits	336	Shared Neighborhood Hits	217
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ITSN1_HUMAN
θ value	1.47631e-18 (rank : 5)	NC score	0.501450 (rank : 70)
Query Neighborhood Hits	332	Target Neighborhood Hits	1757	Shared Neighborhood Hits	280
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	2.7842e-17 (rank : 6)	NC score	0.501589 (rank : 69)
Query Neighborhood Hits	332	Target Neighborhood Hits	1669	Shared Neighborhood Hits	282
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DNMBP_MOUSE
θ value	3.63628e-17 (rank : 7)	NC score	0.635348 (rank : 20)
Query Neighborhood Hits	332	Target Neighborhood Hits	435	Shared Neighborhood Hits	207
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_MOUSE
θ value	6.20254e-17 (rank : 8)	NC score	0.501809 (rank : 68)
Query Neighborhood Hits	332	Target Neighborhood Hits	1371	Shared Neighborhood Hits	261
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SRBS1_MOUSE
θ value	6.85773e-16 (rank : 9)	NC score	0.723064 (rank : 5)
Query Neighborhood Hits	332	Target Neighborhood Hits	409	Shared Neighborhood Hits	212
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

DNMBP_HUMAN
θ value	8.38298e-14 (rank : 10)	NC score	0.632242 (rank : 22)
Query Neighborhood Hits	332	Target Neighborhood Hits	413	Shared Neighborhood Hits	202
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_HUMAN
θ value	1.2105e-12 (rank : 11)	NC score	0.519151 (rank : 60)
Query Neighborhood Hits	332	Target Neighborhood Hits	1173	Shared Neighborhood Hits	256
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

GRB2_HUMAN
θ value	1.58096e-12 (rank : 12)	NC score	0.622772 (rank : 28)
Query Neighborhood Hits	332	Target Neighborhood Hits	310	Shared Neighborhood Hits	193
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	1.58096e-12 (rank : 13)	NC score	0.622693 (rank : 29)
Query Neighborhood Hits	332	Target Neighborhood Hits	312	Shared Neighborhood Hits	193
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCK1_HUMAN
θ value	2.69671e-12 (rank : 14)	NC score	0.620185 (rank : 30)
Query Neighborhood Hits	332	Target Neighborhood Hits	312	Shared Neighborhood Hits	192
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	3.52202e-12 (rank : 15)	NC score	0.615779 (rank : 33)
Query Neighborhood Hits	332	Target Neighborhood Hits	310	Shared Neighborhood Hits	196
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG7_HUMAN
θ value	6.00763e-12 (rank : 16)	NC score	0.624962 (rank : 26)
Query Neighborhood Hits	332	Target Neighborhood Hits	347	Shared Neighborhood Hits	214
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

SH3G2_HUMAN
θ value	2.98157e-11 (rank : 17)	NC score	0.654365 (rank : 16)
Query Neighborhood Hits	332	Target Neighborhood Hits	324	Shared Neighborhood Hits	205
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ARHG7_MOUSE
θ value	3.89403e-11 (rank : 18)	NC score	0.631575 (rank : 23)
Query Neighborhood Hits	332	Target Neighborhood Hits	396	Shared Neighborhood Hits	223
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG6_HUMAN
θ value	6.64225e-11 (rank : 19)	NC score	0.611943 (rank : 34)
Query Neighborhood Hits	332	Target Neighborhood Hits	376	Shared Neighborhood Hits	213
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	1.47974e-10 (rank : 20)	NC score	0.618348 (rank : 32)
Query Neighborhood Hits	332	Target Neighborhood Hits	394	Shared Neighborhood Hits	212
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SH3G2_MOUSE
θ value	1.47974e-10 (rank : 21)	NC score	0.652639 (rank : 18)
Query Neighborhood Hits	332	Target Neighborhood Hits	319	Shared Neighborhood Hits	207
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

M3K9_HUMAN
θ value	1.63604e-09 (rank : 22)	NC score	0.175804 (rank : 182)
Query Neighborhood Hits	332	Target Neighborhood Hits	1123	Shared Neighborhood Hits	187
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

VINEX_HUMAN
θ value	1.63604e-09 (rank : 23)	NC score	0.722897 (rank : 6)
Query Neighborhood Hits	332	Target Neighborhood Hits	270	Shared Neighborhood Hits	203
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PLCG1_MOUSE
θ value	2.13673e-09 (rank : 24)	NC score	0.451739 (rank : 84)
Query Neighborhood Hits	332	Target Neighborhood Hits	314	Shared Neighborhood Hits	166
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRC8_MOUSE
θ value	4.76016e-09 (rank : 25)	NC score	0.654540 (rank : 15)
Query Neighborhood Hits	332	Target Neighborhood Hits	292	Shared Neighborhood Hits	185
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

MYO1E_HUMAN
θ value	6.21693e-09 (rank : 26)	NC score	0.299700 (rank : 124)
Query Neighborhood Hits	332	Target Neighborhood Hits	293	Shared Neighborhood Hits	200
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SH3G3_MOUSE
θ value	8.11959e-09 (rank : 27)	NC score	0.660278 (rank : 10)
Query Neighborhood Hits	332	Target Neighborhood Hits	236	Shared Neighborhood Hits	196
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

GRAP_MOUSE
θ value	1.06045e-08 (rank : 28)	NC score	0.590960 (rank : 43)
Query Neighborhood Hits	332	Target Neighborhood Hits	309	Shared Neighborhood Hits	203
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

M3K10_HUMAN
θ value	1.06045e-08 (rank : 29)	NC score	0.156798 (rank : 205)
Query Neighborhood Hits	332	Target Neighborhood Hits	1071	Shared Neighborhood Hits	167
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MYO1F_MOUSE
θ value	1.06045e-08 (rank : 30)	NC score	0.302324 (rank : 121)
Query Neighborhood Hits	332	Target Neighborhood Hits	262	Shared Neighborhood Hits	199
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SRC8_HUMAN
θ value	1.06045e-08 (rank : 31)	NC score	0.658808 (rank : 11)
Query Neighborhood Hits	332	Target Neighborhood Hits	269	Shared Neighborhood Hits	186
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

VINEX_MOUSE
θ value	1.06045e-08 (rank : 32)	NC score	0.708230 (rank : 7)
Query Neighborhood Hits	332	Target Neighborhood Hits	286	Shared Neighborhood Hits	202
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

MYO1F_HUMAN
θ value	1.38499e-08 (rank : 33)	NC score	0.304185 (rank : 120)
Query Neighborhood Hits	332	Target Neighborhood Hits	275	Shared Neighborhood Hits	203
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

PLCG1_HUMAN
θ value	1.38499e-08 (rank : 34)	NC score	0.436101 (rank : 90)
Query Neighborhood Hits	332	Target Neighborhood Hits	293	Shared Neighborhood Hits	158
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RIMB2_MOUSE
θ value	1.80886e-08 (rank : 35)	NC score	0.454335 (rank : 83)
Query Neighborhood Hits	332	Target Neighborhood Hits	246	Shared Neighborhood Hits	119
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SH3G1_HUMAN
θ value	1.80886e-08 (rank : 36)	NC score	0.630180 (rank : 24)
Query Neighborhood Hits	332	Target Neighborhood Hits	307	Shared Neighborhood Hits	198
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	1.80886e-08 (rank : 37)	NC score	0.632850 (rank : 21)
Query Neighborhood Hits	332	Target Neighborhood Hits	291	Shared Neighborhood Hits	193
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

STAM2_MOUSE
θ value	1.80886e-08 (rank : 38)	NC score	0.599526 (rank : 38)
Query Neighborhood Hits	332	Target Neighborhood Hits	285	Shared Neighborhood Hits	198
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

HCLS1_MOUSE
θ value	2.36244e-08 (rank : 39)	NC score	0.657440 (rank : 12)
Query Neighborhood Hits	332	Target Neighborhood Hits	329	Shared Neighborhood Hits	176
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

NCF1_MOUSE
θ value	2.36244e-08 (rank : 40)	NC score	0.623489 (rank : 27)
Query Neighborhood Hits	332	Target Neighborhood Hits	198	Shared Neighborhood Hits	169
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SH3G3_HUMAN
θ value	4.0297e-08 (rank : 41)	NC score	0.640641 (rank : 19)
Query Neighborhood Hits	332	Target Neighborhood Hits	222	Shared Neighborhood Hits	185
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRBS1_HUMAN
θ value	4.0297e-08 (rank : 42)	NC score	0.685266 (rank : 9)
Query Neighborhood Hits	332	Target Neighborhood Hits	396	Shared Neighborhood Hits	214
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

HCLS1_HUMAN
θ value	5.26297e-08 (rank : 43)	NC score	0.656580 (rank : 13)
Query Neighborhood Hits	332	Target Neighborhood Hits	358	Shared Neighborhood Hits	171
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

VAV_MOUSE
θ value	5.26297e-08 (rank : 44)	NC score	0.517500 (rank : 62)
Query Neighborhood Hits	332	Target Neighborhood Hits	430	Shared Neighborhood Hits	199
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

NCF1_HUMAN
θ value	8.97725e-08 (rank : 45)	NC score	0.619308 (rank : 31)
Query Neighborhood Hits	332	Target Neighborhood Hits	198	Shared Neighborhood Hits	158
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

VAV_HUMAN
θ value	1.17247e-07 (rank : 46)	NC score	0.515529 (rank : 63)
Query Neighborhood Hits	332	Target Neighborhood Hits	452	Shared Neighborhood Hits	197
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

NCF2_HUMAN
θ value	1.53129e-07 (rank : 47)	NC score	0.707221 (rank : 8)
Query Neighborhood Hits	332	Target Neighborhood Hits	229	Shared Neighborhood Hits	173
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PPIP1_HUMAN
θ value	2.61198e-07 (rank : 48)	NC score	0.595138 (rank : 41)
Query Neighborhood Hits	332	Target Neighborhood Hits	389	Shared Neighborhood Hits	208
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI2_HUMAN
θ value	3.41135e-07 (rank : 49)	NC score	0.652973 (rank : 17)
Query Neighborhood Hits	332	Target Neighborhood Hits	350	Shared Neighborhood Hits	202
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	3.41135e-07 (rank : 50)	NC score	0.656472 (rank : 14)
Query Neighborhood Hits	332	Target Neighborhood Hits	266	Shared Neighborhood Hits	196
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

STAC_HUMAN
θ value	5.81887e-07 (rank : 51)	NC score	0.600699 (rank : 37)
Query Neighborhood Hits	332	Target Neighborhood Hits	276	Shared Neighborhood Hits	186
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI1_MOUSE
θ value	7.59969e-07 (rank : 52)	NC score	0.628291 (rank : 25)
Query Neighborhood Hits	332	Target Neighborhood Hits	246	Shared Neighborhood Hits	178
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ASPP2_HUMAN
θ value	7.59969e-07 (rank : 53)	NC score	0.292641 (rank : 127)
Query Neighborhood Hits	332	Target Neighborhood Hits	1156	Shared Neighborhood Hits	196
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

M3K11_HUMAN
θ value	7.59969e-07 (rank : 54)	NC score	0.178204 (rank : 178)
Query Neighborhood Hits	332	Target Neighborhood Hits	1136	Shared Neighborhood Hits	191
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3KL4_HUMAN
θ value	7.59969e-07 (rank : 55)	NC score	0.188122 (rank : 173)
Query Neighborhood Hits	332	Target Neighborhood Hits	1087	Shared Neighborhood Hits	186
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

PLCG2_HUMAN
θ value	7.59969e-07 (rank : 56)	NC score	0.426132 (rank : 95)
Query Neighborhood Hits	332	Target Neighborhood Hits	280	Shared Neighborhood Hits	154
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

BCAR1_MOUSE
θ value	9.92553e-07 (rank : 57)	NC score	0.476374 (rank : 77)
Query Neighborhood Hits	332	Target Neighborhood Hits	438	Shared Neighborhood Hits	174
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DDEF1_MOUSE
θ value	9.92553e-07 (rank : 58)	NC score	0.324345 (rank : 113)
Query Neighborhood Hits	332	Target Neighborhood Hits	592	Shared Neighborhood Hits	166
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GRAP_HUMAN
θ value	9.92553e-07 (rank : 59)	NC score	0.575116 (rank : 47)
Query Neighborhood Hits	332	Target Neighborhood Hits	307	Shared Neighborhood Hits	201
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

BCAR1_HUMAN
θ value	1.29631e-06 (rank : 60)	NC score	0.464245 (rank : 80)
Query Neighborhood Hits	332	Target Neighborhood Hits	554	Shared Neighborhood Hits	177
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

STAM1_HUMAN
θ value	1.29631e-06 (rank : 61)	NC score	0.599034 (rank : 39)
Query Neighborhood Hits	332	Target Neighborhood Hits	271	Shared Neighborhood Hits	196
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	1.29631e-06 (rank : 62)	NC score	0.598732 (rank : 40)
Query Neighborhood Hits	332	Target Neighborhood Hits	273	Shared Neighborhood Hits	194
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PPIP1_MOUSE
θ value	1.69304e-06 (rank : 63)	NC score	0.594325 (rank : 42)
Query Neighborhood Hits	332	Target Neighborhood Hits	377	Shared Neighborhood Hits	216
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ABI1_HUMAN
θ value	2.21117e-06 (rank : 64)	NC score	0.610610 (rank : 35)
Query Neighborhood Hits	332	Target Neighborhood Hits	257	Shared Neighborhood Hits	178
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

STAC_MOUSE
θ value	2.21117e-06 (rank : 65)	NC score	0.586638 (rank : 45)
Query Neighborhood Hits	332	Target Neighborhood Hits	268	Shared Neighborhood Hits	184
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SHAN1_HUMAN
θ value	2.88788e-06 (rank : 66)	NC score	0.229133 (rank : 160)
Query Neighborhood Hits	332	Target Neighborhood Hits	1041	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SNX9_HUMAN
θ value	4.92598e-06 (rank : 67)	NC score	0.322164 (rank : 115)
Query Neighborhood Hits	332	Target Neighborhood Hits	148	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

PACN2_MOUSE
θ value	6.43352e-06 (rank : 68)	NC score	0.540537 (rank : 56)
Query Neighborhood Hits	332	Target Neighborhood Hits	382	Shared Neighborhood Hits	199
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RIMB2_HUMAN
θ value	6.43352e-06 (rank : 69)	NC score	0.445146 (rank : 86)
Query Neighborhood Hits	332	Target Neighborhood Hits	263	Shared Neighborhood Hits	130
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

STAM2_HUMAN
θ value	6.43352e-06 (rank : 70)	NC score	0.574980 (rank : 48)
Query Neighborhood Hits	332	Target Neighborhood Hits	288	Shared Neighborhood Hits	195
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

OSTF1_MOUSE
θ value	8.40245e-06 (rank : 71)	NC score	0.497978 (rank : 73)
Query Neighborhood Hits	332	Target Neighborhood Hits	467	Shared Neighborhood Hits	200
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ASPP1_HUMAN
θ value	1.09739e-05 (rank : 72)	NC score	0.337868 (rank : 109)
Query Neighborhood Hits	332	Target Neighborhood Hits	956	Shared Neighborhood Hits	208
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	1.09739e-05 (rank : 73)	NC score	0.332719 (rank : 110)
Query Neighborhood Hits	332	Target Neighborhood Hits	1244	Shared Neighborhood Hits	211
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CRKL_MOUSE
θ value	1.09739e-05 (rank : 74)	NC score	0.546161 (rank : 51)
Query Neighborhood Hits	332	Target Neighborhood Hits	307	Shared Neighborhood Hits	188
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

OSTF1_HUMAN
θ value	1.09739e-05 (rank : 75)	NC score	0.508216 (rank : 66)
Query Neighborhood Hits	332	Target Neighborhood Hits	466	Shared Neighborhood Hits	200
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

VAV2_HUMAN
θ value	1.09739e-05 (rank : 76)	NC score	0.475836 (rank : 78)
Query Neighborhood Hits	332	Target Neighborhood Hits	453	Shared Neighborhood Hits	188
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	1.09739e-05 (rank : 77)	NC score	0.475167 (rank : 79)
Query Neighborhood Hits	332	Target Neighborhood Hits	456	Shared Neighborhood Hits	190
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CRKL_HUMAN
θ value	1.43324e-05 (rank : 78)	NC score	0.554988 (rank : 50)
Query Neighborhood Hits	332	Target Neighborhood Hits	313	Shared Neighborhood Hits	191
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SRGP2_HUMAN
θ value	2.44474e-05 (rank : 79)	NC score	0.329122 (rank : 112)
Query Neighborhood Hits	332	Target Neighborhood Hits	331	Shared Neighborhood Hits	157
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RHG26_HUMAN
θ value	4.1701e-05 (rank : 80)	NC score	0.324209 (rank : 114)
Query Neighborhood Hits	332	Target Neighborhood Hits	281	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SRGP2_MOUSE
θ value	4.1701e-05 (rank : 81)	NC score	0.332189 (rank : 111)
Query Neighborhood Hits	332	Target Neighborhood Hits	324	Shared Neighborhood Hits	160
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CRK_MOUSE
θ value	5.44631e-05 (rank : 82)	NC score	0.546067 (rank : 52)
Query Neighborhood Hits	332	Target Neighborhood Hits	314	Shared Neighborhood Hits	193
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DDEF2_HUMAN
θ value	5.44631e-05 (rank : 83)	NC score	0.290193 (rank : 128)
Query Neighborhood Hits	332	Target Neighborhood Hits	599	Shared Neighborhood Hits	169
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP2_HUMAN
θ value	5.44631e-05 (rank : 84)	NC score	0.570205 (rank : 49)
Query Neighborhood Hits	332	Target Neighborhood Hits	304	Shared Neighborhood Hits	191
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCF4_HUMAN
θ value	5.44631e-05 (rank : 85)	NC score	0.589420 (rank : 44)
Query Neighborhood Hits	332	Target Neighborhood Hits	161	Shared Neighborhood Hits	128
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SPTA2_HUMAN
θ value	5.44631e-05 (rank : 86)	NC score	0.269221 (rank : 139)
Query Neighborhood Hits	332	Target Neighborhood Hits	888	Shared Neighborhood Hits	212
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DDEF2_MOUSE
θ value	7.1131e-05 (rank : 87)	NC score	0.296393 (rank : 126)
Query Neighborhood Hits	332	Target Neighborhood Hits	625	Shared Neighborhood Hits	171
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

AHI1_HUMAN
θ value	9.29e-05 (rank : 88)	NC score	0.435306 (rank : 91)
Query Neighborhood Hits	332	Target Neighborhood Hits	537	Shared Neighborhood Hits	197
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

NCF4_MOUSE
θ value	9.29e-05 (rank : 89)	NC score	0.605832 (rank : 36)
Query Neighborhood Hits	332	Target Neighborhood Hits	177	Shared Neighborhood Hits	145
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRAP2_MOUSE
θ value	0.000121331 (rank : 90)	NC score	0.576281 (rank : 46)
Query Neighborhood Hits	332	Target Neighborhood Hits	297	Shared Neighborhood Hits	194
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

RIMB1_MOUSE
θ value	0.000121331 (rank : 91)	NC score	0.257922 (rank : 143)
Query Neighborhood Hits	332	Target Neighborhood Hits	1376	Shared Neighborhood Hits	214
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SNX9_MOUSE
θ value	0.000121331 (rank : 92)	NC score	0.288244 (rank : 129)
Query Neighborhood Hits	332	Target Neighborhood Hits	141	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SRGP1_HUMAN
θ value	0.000121331 (rank : 93)	NC score	0.311762 (rank : 117)
Query Neighborhood Hits	332	Target Neighborhood Hits	390	Shared Neighborhood Hits	159
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

PACN2_HUMAN
θ value	0.000158464 (rank : 94)	NC score	0.542174 (rank : 53)
Query Neighborhood Hits	332	Target Neighborhood Hits	339	Shared Neighborhood Hits	198
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

VAV3_HUMAN
θ value	0.000158464 (rank : 95)	NC score	0.448893 (rank : 85)
Query Neighborhood Hits	332	Target Neighborhood Hits	398	Shared Neighborhood Hits	186
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FNBP2_HUMAN
θ value	0.00020696 (rank : 96)	NC score	0.311727 (rank : 118)
Query Neighborhood Hits	332	Target Neighborhood Hits	432	Shared Neighborhood Hits	162
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

PACN1_HUMAN
θ value	0.00020696 (rank : 97)	NC score	0.528092 (rank : 58)
Query Neighborhood Hits	332	Target Neighborhood Hits	320	Shared Neighborhood Hits	188
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

EFS_MOUSE
θ value	0.000270298 (rank : 98)	NC score	0.444925 (rank : 87)
Query Neighborhood Hits	332	Target Neighborhood Hits	389	Shared Neighborhood Hits	155
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FGR_HUMAN
θ value	0.000270298 (rank : 99)	NC score	0.172833 (rank : 187)
Query Neighborhood Hits	332	Target Neighborhood Hits	1067	Shared Neighborhood Hits	177
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLY_HUMAN
θ value	0.000270298 (rank : 100)	NC score	0.254551 (rank : 146)
Query Neighborhood Hits	332	Target Neighborhood Hits	81	Shared Neighborhood Hits	59
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	0.000270298 (rank : 101)	NC score	0.272293 (rank : 136)
Query Neighborhood Hits	332	Target Neighborhood Hits	108	Shared Neighborhood Hits	67
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

VAV3_MOUSE
θ value	0.000270298 (rank : 102)	NC score	0.442421 (rank : 88)
Query Neighborhood Hits	332	Target Neighborhood Hits	404	Shared Neighborhood Hits	184
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

AHI1_MOUSE
θ value	0.000461057 (rank : 103)	NC score	0.430018 (rank : 94)
Query Neighborhood Hits	332	Target Neighborhood Hits	496	Shared Neighborhood Hits	195
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG4_HUMAN
θ value	0.000461057 (rank : 104)	NC score	0.434771 (rank : 93)
Query Neighborhood Hits	332	Target Neighborhood Hits	242	Shared Neighborhood Hits	160
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CASL_HUMAN
θ value	0.000461057 (rank : 105)	NC score	0.435047 (rank : 92)
Query Neighborhood Hits	332	Target Neighborhood Hits	259	Shared Neighborhood Hits	152
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0.000461057 (rank : 106)	NC score	0.438198 (rank : 89)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	149
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

ABI3_MOUSE
θ value	0.000602161 (rank : 107)	NC score	0.541765 (rank : 54)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	152
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CRK_HUMAN
θ value	0.000602161 (rank : 108)	NC score	0.531038 (rank : 57)
Query Neighborhood Hits	332	Target Neighborhood Hits	308	Shared Neighborhood Hits	195
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DBNL_HUMAN
θ value	0.000602161 (rank : 109)	NC score	0.514019 (rank : 65)
Query Neighborhood Hits	332	Target Neighborhood Hits	244	Shared Neighborhood Hits	148
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.000602161 (rank : 110)	NC score	0.507713 (rank : 67)
Query Neighborhood Hits	332	Target Neighborhood Hits	306	Shared Neighborhood Hits	156
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NEBL_HUMAN
θ value	0.000602161 (rank : 111)	NC score	0.462163 (rank : 81)
Query Neighborhood Hits	332	Target Neighborhood Hits	457	Shared Neighborhood Hits	195
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

RHG04_HUMAN
θ value	0.000602161 (rank : 112)	NC score	0.363137 (rank : 104)
Query Neighborhood Hits	332	Target Neighborhood Hits	307	Shared Neighborhood Hits	164
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ARHG9_MOUSE
θ value	0.000786445 (rank : 113)	NC score	0.419540 (rank : 99)
Query Neighborhood Hits	332	Target Neighborhood Hits	234	Shared Neighborhood Hits	155
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

IASPP_MOUSE
θ value	0.000786445 (rank : 114)	NC score	0.319889 (rank : 116)
Query Neighborhood Hits	332	Target Neighborhood Hits	1024	Shared Neighborhood Hits	179
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PACN1_MOUSE
θ value	0.000786445 (rank : 115)	NC score	0.527008 (rank : 59)
Query Neighborhood Hits	332	Target Neighborhood Hits	283	Shared Neighborhood Hits	185
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ABI3_HUMAN
θ value	0.00102713 (rank : 116)	NC score	0.540764 (rank : 55)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	151
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG9_HUMAN
θ value	0.00102713 (rank : 117)	NC score	0.420263 (rank : 98)
Query Neighborhood Hits	332	Target Neighborhood Hits	235	Shared Neighborhood Hits	156
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

IASPP_HUMAN
θ value	0.00102713 (rank : 118)	NC score	0.347796 (rank : 107)
Query Neighborhood Hits	332	Target Neighborhood Hits	688	Shared Neighborhood Hits	173
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PACN3_HUMAN
θ value	0.00102713 (rank : 119)	NC score	0.499360 (rank : 72)
Query Neighborhood Hits	332	Target Neighborhood Hits	385	Shared Neighborhood Hits	197
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.00102713 (rank : 120)	NC score	0.500043 (rank : 71)
Query Neighborhood Hits	332	Target Neighborhood Hits	380	Shared Neighborhood Hits	198
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

RIMB1_HUMAN
θ value	0.00102713 (rank : 121)	NC score	0.264387 (rank : 142)
Query Neighborhood Hits	332	Target Neighborhood Hits	1479	Shared Neighborhood Hits	198
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

STAC3_HUMAN
θ value	0.00102713 (rank : 122)	NC score	0.515503 (rank : 64)
Query Neighborhood Hits	332	Target Neighborhood Hits	228	Shared Neighborhood Hits	148
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.00102713 (rank : 123)	NC score	0.518305 (rank : 61)
Query Neighborhood Hits	332	Target Neighborhood Hits	232	Shared Neighborhood Hits	149
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ANK2_HUMAN
θ value	0.00175202 (rank : 124)	NC score	0.051207 (rank : 468)
Query Neighborhood Hits	332	Target Neighborhood Hits	1615	Shared Neighborhood Hits	90
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CSKP_HUMAN
θ value	0.00175202 (rank : 125)	NC score	0.080050 (rank : 327)
Query Neighborhood Hits	332	Target Neighborhood Hits	1022	Shared Neighborhood Hits	118
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

FGR_MOUSE
θ value	0.00175202 (rank : 126)	NC score	0.163886 (rank : 198)
Query Neighborhood Hits	332	Target Neighborhood Hits	1069	Shared Neighborhood Hits	178
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LASP1_HUMAN
θ value	0.00175202 (rank : 127)	NC score	0.490890 (rank : 74)
Query Neighborhood Hits	332	Target Neighborhood Hits	293	Shared Neighborhood Hits	162
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00175202 (rank : 128)	NC score	0.487901 (rank : 75)
Query Neighborhood Hits	332	Target Neighborhood Hits	297	Shared Neighborhood Hits	162
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SHAN2_MOUSE
θ value	0.00175202 (rank : 129)	NC score	0.280473 (rank : 134)
Query Neighborhood Hits	332	Target Neighborhood Hits	446	Shared Neighborhood Hits	130
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

STS1_HUMAN
θ value	0.00175202 (rank : 130)	NC score	0.255720 (rank : 144)
Query Neighborhood Hits	332	Target Neighborhood Hits	106	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

BTK_HUMAN
θ value	0.00228821 (rank : 131)	NC score	0.151487 (rank : 209)
Query Neighborhood Hits	332	Target Neighborhood Hits	1026	Shared Neighborhood Hits	173
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

STS1_MOUSE
θ value	0.00228821 (rank : 132)	NC score	0.255446 (rank : 145)
Query Neighborhood Hits	332	Target Neighborhood Hits	104	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ARHG4_MOUSE
θ value	0.00298849 (rank : 133)	NC score	0.361271 (rank : 105)
Query Neighborhood Hits	332	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BTK_MOUSE
θ value	0.00298849 (rank : 134)	NC score	0.145475 (rank : 212)
Query Neighborhood Hits	332	Target Neighborhood Hits	1017	Shared Neighborhood Hits	163
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

NEBU_HUMAN
θ value	0.00298849 (rank : 135)	NC score	0.389161 (rank : 101)
Query Neighborhood Hits	332	Target Neighborhood Hits	420	Shared Neighborhood Hits	177
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

AFF2_MOUSE
θ value	0.00390308 (rank : 136)	NC score	0.066982 (rank : 368)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	24
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

BAIP2_HUMAN
θ value	0.00390308 (rank : 137)	NC score	0.197911 (rank : 167)
Query Neighborhood Hits	332	Target Neighborhood Hits	192	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	0.00390308 (rank : 138)	NC score	0.199552 (rank : 166)
Query Neighborhood Hits	332	Target Neighborhood Hits	185	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

FYN_HUMAN
θ value	0.00390308 (rank : 139)	NC score	0.168730 (rank : 192)
Query Neighborhood Hits	332	Target Neighborhood Hits	1078	Shared Neighborhood Hits	183
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.00390308 (rank : 140)	NC score	0.171746 (rank : 189)
Query Neighborhood Hits	332	Target Neighborhood Hits	1073	Shared Neighborhood Hits	183
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

RHG25_HUMAN
θ value	0.00390308 (rank : 141)	NC score	0.086065 (rank : 314)
Query Neighborhood Hits	332	Target Neighborhood Hits	550	Shared Neighborhood Hits	53
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SPTA1_HUMAN
θ value	0.00390308 (rank : 142)	NC score	0.236941 (rank : 155)
Query Neighborhood Hits	332	Target Neighborhood Hits	748	Shared Neighborhood Hits	190
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

AMPH_HUMAN
θ value	0.00509761 (rank : 143)	NC score	0.252257 (rank : 147)
Query Neighborhood Hits	332	Target Neighborhood Hits	455	Shared Neighborhood Hits	106
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

BIN1_HUMAN
θ value	0.00509761 (rank : 144)	NC score	0.237048 (rank : 154)
Query Neighborhood Hits	332	Target Neighborhood Hits	335	Shared Neighborhood Hits	91
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

MAGE1_HUMAN
θ value	0.00665767 (rank : 145)	NC score	0.045308 (rank : 493)
Query Neighborhood Hits	332	Target Neighborhood Hits	1389	Shared Neighborhood Hits	67
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CT032_HUMAN
θ value	0.0113563 (rank : 146)	NC score	0.483704 (rank : 76)
Query Neighborhood Hits	332	Target Neighborhood Hits	235	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

TCGAP_HUMAN
θ value	0.0113563 (rank : 147)	NC score	0.237182 (rank : 153)
Query Neighborhood Hits	332	Target Neighborhood Hits	872	Shared Neighborhood Hits	144
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

AMPH_MOUSE
θ value	0.0193708 (rank : 148)	NC score	0.249262 (rank : 148)
Query Neighborhood Hits	332	Target Neighborhood Hits	291	Shared Neighborhood Hits	91
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ARHG5_HUMAN
θ value	0.0193708 (rank : 149)	NC score	0.286337 (rank : 131)
Query Neighborhood Hits	332	Target Neighborhood Hits	172	Shared Neighborhood Hits	102
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

CSKP_MOUSE
θ value	0.0193708 (rank : 150)	NC score	0.076938 (rank : 338)
Query Neighborhood Hits	332	Target Neighborhood Hits	1027	Shared Neighborhood Hits	125
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DOCK1_HUMAN
θ value	0.0193708 (rank : 151)	NC score	0.183618 (rank : 176)
Query Neighborhood Hits	332	Target Neighborhood Hits	191	Shared Neighborhood Hits	119
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SPTA1_MOUSE
θ value	0.0193708 (rank : 152)	NC score	0.238970 (rank : 152)
Query Neighborhood Hits	332	Target Neighborhood Hits	675	Shared Neighborhood Hits	181
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TCGAP_MOUSE
θ value	0.0193708 (rank : 153)	NC score	0.266947 (rank : 140)
Query Neighborhood Hits	332	Target Neighborhood Hits	409	Shared Neighborhood Hits	144
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

YES_HUMAN
θ value	0.0193708 (rank : 154)	NC score	0.164804 (rank : 195)
Query Neighborhood Hits	332	Target Neighborhood Hits	1059	Shared Neighborhood Hits	180
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	0.0193708 (rank : 155)	NC score	0.166664 (rank : 193)
Query Neighborhood Hits	332	Target Neighborhood Hits	1052	Shared Neighborhood Hits	180
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BIN1_MOUSE
θ value	0.0252991 (rank : 156)	NC score	0.233904 (rank : 157)
Query Neighborhood Hits	332	Target Neighborhood Hits	283	Shared Neighborhood Hits	86
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

FUT8_HUMAN
θ value	0.0252991 (rank : 157)	NC score	0.156665 (rank : 206)
Query Neighborhood Hits	332	Target Neighborhood Hits	67	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FUT8_MOUSE
θ value	0.0252991 (rank : 158)	NC score	0.153271 (rank : 208)
Query Neighborhood Hits	332	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

NGEF_MOUSE
θ value	0.0252991 (rank : 159)	NC score	0.271440 (rank : 138)
Query Neighborhood Hits	332	Target Neighborhood Hits	228	Shared Neighborhood Hits	95
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_MOUSE
θ value	0.0330416 (rank : 160)	NC score	0.240218 (rank : 151)
Query Neighborhood Hits	332	Target Neighborhood Hits	152	Shared Neighborhood Hits	72
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BI2L1_HUMAN
θ value	0.0330416 (rank : 161)	NC score	0.217428 (rank : 163)
Query Neighborhood Hits	332	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

EM55_MOUSE
θ value	0.0330416 (rank : 162)	NC score	0.187935 (rank : 174)
Query Neighborhood Hits	332	Target Neighborhood Hits	221	Shared Neighborhood Hits	93
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

NPHP1_HUMAN
θ value	0.0330416 (rank : 163)	NC score	0.421060 (rank : 97)
Query Neighborhood Hits	332	Target Neighborhood Hits	288	Shared Neighborhood Hits	163
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

BLK_MOUSE
θ value	0.0431538 (rank : 164)	NC score	0.121369 (rank : 243)
Query Neighborhood Hits	332	Target Neighborhood Hits	992	Shared Neighborhood Hits	126
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

COA2_HUMAN
θ value	0.0431538 (rank : 165)	NC score	0.041095 (rank : 503)
Query Neighborhood Hits	332	Target Neighborhood Hits	184	Shared Neighborhood Hits	9
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

EFS_HUMAN
θ value	0.0431538 (rank : 166)	NC score	0.421299 (rank : 96)
Query Neighborhood Hits	332	Target Neighborhood Hits	348	Shared Neighborhood Hits	153
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

NGEF_HUMAN
θ value	0.0431538 (rank : 167)	NC score	0.266479 (rank : 141)
Query Neighborhood Hits	332	Target Neighborhood Hits	166	Shared Neighborhood Hits	87
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_MOUSE
θ value	0.0431538 (rank : 168)	NC score	0.402040 (rank : 100)
Query Neighborhood Hits	332	Target Neighborhood Hits	114	Shared Neighborhood Hits	103
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SASH1_HUMAN
θ value	0.0431538 (rank : 169)	NC score	0.183192 (rank : 177)
Query Neighborhood Hits	332	Target Neighborhood Hits	292	Shared Neighborhood Hits	71
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SHLB1_HUMAN
θ value	0.0431538 (rank : 170)	NC score	0.296554 (rank : 125)
Query Neighborhood Hits	332	Target Neighborhood Hits	96	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	0.0431538 (rank : 171)	NC score	0.301126 (rank : 123)
Query Neighborhood Hits	332	Target Neighborhood Hits	101	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SMC3_HUMAN
θ value	0.0431538 (rank : 172)	NC score	0.065610 (rank : 377)
Query Neighborhood Hits	332	Target Neighborhood Hits	1186	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	0.0431538 (rank : 173)	NC score	0.065682 (rank : 375)
Query Neighborhood Hits	332	Target Neighborhood Hits	1187	Shared Neighborhood Hits	74
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

BLK_HUMAN
θ value	0.0563607 (rank : 174)	NC score	0.125302 (rank : 240)
Query Neighborhood Hits	332	Target Neighborhood Hits	994	Shared Neighborhood Hits	136
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FYB_HUMAN
θ value	0.0563607 (rank : 175)	NC score	0.078310 (rank : 333)
Query Neighborhood Hits	332	Target Neighborhood Hits	379	Shared Neighborhood Hits	45
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

MPP6_HUMAN
θ value	0.0563607 (rank : 176)	NC score	0.169683 (rank : 191)
Query Neighborhood Hits	332	Target Neighborhood Hits	180	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

ARHGG_HUMAN
θ value	0.0736092 (rank : 177)	NC score	0.214603 (rank : 164)
Query Neighborhood Hits	332	Target Neighborhood Hits	129	Shared Neighborhood Hits	55
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NPHP1_MOUSE
θ value	0.0736092 (rank : 178)	NC score	0.461593 (rank : 82)
Query Neighborhood Hits	332	Target Neighborhood Hits	267	Shared Neighborhood Hits	181
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STS2_HUMAN
θ value	0.0736092 (rank : 179)	NC score	0.284128 (rank : 132)
Query Neighborhood Hits	332	Target Neighborhood Hits	108	Shared Neighborhood Hits	92
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

EM55_HUMAN
θ value	0.0961366 (rank : 180)	NC score	0.188540 (rank : 172)
Query Neighborhood Hits	332	Target Neighborhood Hits	228	Shared Neighborhood Hits	97
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

ES8L3_HUMAN
θ value	0.0961366 (rank : 181)	NC score	0.271727 (rank : 137)
Query Neighborhood Hits	332	Target Neighborhood Hits	206	Shared Neighborhood Hits	119
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	0.0961366 (rank : 182)	NC score	0.304299 (rank : 119)
Query Neighborhood Hits	332	Target Neighborhood Hits	168	Shared Neighborhood Hits	135
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

MPP6_MOUSE
θ value	0.0961366 (rank : 183)	NC score	0.164462 (rank : 197)
Query Neighborhood Hits	332	Target Neighborhood Hits	187	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NACAM_MOUSE
θ value	0.0961366 (rank : 184)	NC score	0.071919 (rank : 354)
Query Neighborhood Hits	332	Target Neighborhood Hits	1866	Shared Neighborhood Hits	102
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MLL3_MOUSE
θ value	0.125558 (rank : 185)	NC score	0.040058 (rank : 507)
Query Neighborhood Hits	332	Target Neighborhood Hits	1399	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MPP2_HUMAN
θ value	0.125558 (rank : 186)	NC score	0.132161 (rank : 229)
Query Neighborhood Hits	332	Target Neighborhood Hits	173	Shared Neighborhood Hits	71
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

PKCB1_HUMAN
θ value	0.125558 (rank : 187)	NC score	0.040503 (rank : 504)
Query Neighborhood Hits	332	Target Neighborhood Hits	488	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

TXND2_HUMAN
θ value	0.125558 (rank : 188)	NC score	0.068264 (rank : 364)
Query Neighborhood Hits	332	Target Neighborhood Hits	793	Shared Neighborhood Hits	56
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

FRK_HUMAN
θ value	0.163984 (rank : 189)	NC score	0.134014 (rank : 227)
Query Neighborhood Hits	332	Target Neighborhood Hits	1058	Shared Neighborhood Hits	175
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

P85A_MOUSE
θ value	0.163984 (rank : 190)	NC score	0.200929 (rank : 165)
Query Neighborhood Hits	332	Target Neighborhood Hits	435	Shared Neighborhood Hits	123
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SASH1_MOUSE
θ value	0.163984 (rank : 191)	NC score	0.174349 (rank : 184)
Query Neighborhood Hits	332	Target Neighborhood Hits	263	Shared Neighborhood Hits	67
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ECM1_MOUSE
θ value	0.279714 (rank : 192)	NC score	0.050527 (rank : 474)
Query Neighborhood Hits	332	Target Neighborhood Hits	105	Shared Neighborhood Hits	13
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

K1802_HUMAN
θ value	0.279714 (rank : 193)	NC score	0.027228 (rank : 524)
Query Neighborhood Hits	332	Target Neighborhood Hits	1378	Shared Neighborhood Hits	56
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MPP5_HUMAN
θ value	0.279714 (rank : 194)	NC score	0.135193 (rank : 224)
Query Neighborhood Hits	332	Target Neighborhood Hits	231	Shared Neighborhood Hits	72
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.279714 (rank : 195)	NC score	0.134522 (rank : 225)
Query Neighborhood Hits	332	Target Neighborhood Hits	226	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

EPS8_MOUSE
θ value	0.365318 (rank : 196)	NC score	0.228083 (rank : 161)
Query Neighborhood Hits	332	Target Neighborhood Hits	157	Shared Neighborhood Hits	118
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

GRIN1_MOUSE
θ value	0.365318 (rank : 197)	NC score	0.045169 (rank : 494)
Query Neighborhood Hits	332	Target Neighborhood Hits	337	Shared Neighborhood Hits	26
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

MGRN1_HUMAN
θ value	0.365318 (rank : 198)	NC score	0.040183 (rank : 506)
Query Neighborhood Hits	332	Target Neighborhood Hits	192	Shared Neighborhood Hits	6
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MPP2_MOUSE
θ value	0.365318 (rank : 199)	NC score	0.130876 (rank : 232)
Query Neighborhood Hits	332	Target Neighborhood Hits	189	Shared Neighborhood Hits	70
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

SNX18_HUMAN
θ value	0.365318 (rank : 200)	NC score	0.374684 (rank : 103)
Query Neighborhood Hits	332	Target Neighborhood Hits	207	Shared Neighborhood Hits	131
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0.365318 (rank : 201)	NC score	0.382408 (rank : 102)
Query Neighborhood Hits	332	Target Neighborhood Hits	198	Shared Neighborhood Hits	130
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ZO1_MOUSE
θ value	0.365318 (rank : 202)	NC score	0.031344 (rank : 517)
Query Neighborhood Hits	332	Target Neighborhood Hits	453	Shared Neighborhood Hits	38
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ACK1_HUMAN
θ value	0.47712 (rank : 203)	NC score	0.060208 (rank : 399)
Query Neighborhood Hits	332	Target Neighborhood Hits	1140	Shared Neighborhood Hits	90
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	0.47712 (rank : 204)	NC score	0.061721 (rank : 390)
Query Neighborhood Hits	332	Target Neighborhood Hits	1080	Shared Neighborhood Hits	96
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

EEA1_HUMAN
θ value	0.47712 (rank : 205)	NC score	0.055199 (rank : 440)
Query Neighborhood Hits	332	Target Neighborhood Hits	1796	Shared Neighborhood Hits	100
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ES8L2_MOUSE
θ value	0.47712 (rank : 206)	NC score	0.236207 (rank : 156)
Query Neighborhood Hits	332	Target Neighborhood Hits	169	Shared Neighborhood Hits	119
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MDC1_MOUSE
θ value	0.47712 (rank : 207)	NC score	0.048791 (rank : 485)
Query Neighborhood Hits	332	Target Neighborhood Hits	998	Shared Neighborhood Hits	61
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MYH11_HUMAN
θ value	0.47712 (rank : 208)	NC score	0.065281 (rank : 378)
Query Neighborhood Hits	332	Target Neighborhood Hits	1806	Shared Neighborhood Hits	110
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

ERC2_HUMAN
θ value	0.62314 (rank : 209)	NC score	0.057873 (rank : 418)
Query Neighborhood Hits	332	Target Neighborhood Hits	1156	Shared Neighborhood Hits	83
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	0.62314 (rank : 210)	NC score	0.059573 (rank : 406)
Query Neighborhood Hits	332	Target Neighborhood Hits	1166	Shared Neighborhood Hits	85
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ES8L2_HUMAN
θ value	0.62314 (rank : 211)	NC score	0.242015 (rank : 150)
Query Neighborhood Hits	332	Target Neighborhood Hits	193	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

JIP2_HUMAN
θ value	0.62314 (rank : 212)	NC score	0.133629 (rank : 228)
Query Neighborhood Hits	332	Target Neighborhood Hits	288	Shared Neighborhood Hits	70
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.62314 (rank : 213)	NC score	0.134219 (rank : 226)
Query Neighborhood Hits	332	Target Neighborhood Hits	144	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

LYN_HUMAN
θ value	0.62314 (rank : 214)	NC score	0.131486 (rank : 231)
Query Neighborhood Hits	332	Target Neighborhood Hits	1022	Shared Neighborhood Hits	150
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NOXO1_HUMAN
θ value	0.62314 (rank : 215)	NC score	0.302045 (rank : 122)
Query Neighborhood Hits	332	Target Neighborhood Hits	100	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PTK6_HUMAN
θ value	0.62314 (rank : 216)	NC score	0.113662 (rank : 257)
Query Neighborhood Hits	332	Target Neighborhood Hits	1020	Shared Neighborhood Hits	153
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SRC_HUMAN
θ value	0.62314 (rank : 217)	NC score	0.159971 (rank : 203)
Query Neighborhood Hits	332	Target Neighborhood Hits	1058	Shared Neighborhood Hits	182
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TRI39_HUMAN
θ value	0.62314 (rank : 218)	NC score	0.015103 (rank : 545)
Query Neighborhood Hits	332	Target Neighborhood Hits	693	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

EPS8_HUMAN
θ value	0.813845 (rank : 219)	NC score	0.227598 (rank : 162)
Query Neighborhood Hits	332	Target Neighborhood Hits	151	Shared Neighborhood Hits	103
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

MYH14_HUMAN
θ value	0.813845 (rank : 220)	NC score	0.055058 (rank : 442)
Query Neighborhood Hits	332	Target Neighborhood Hits	995	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

NIN_HUMAN
θ value	0.813845 (rank : 221)	NC score	0.050678 (rank : 471)
Query Neighborhood Hits	332	Target Neighborhood Hits	1416	Shared Neighborhood Hits	78
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NIN_MOUSE
θ value	0.813845 (rank : 222)	NC score	0.049997 (rank : 483)
Query Neighborhood Hits	332	Target Neighborhood Hits	1376	Shared Neighborhood Hits	80
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

QSCN6_HUMAN
θ value	0.813845 (rank : 223)	NC score	0.029184 (rank : 520)
Query Neighborhood Hits	332	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

TARA_HUMAN
θ value	0.813845 (rank : 224)	NC score	0.047341 (rank : 487)
Query Neighborhood Hits	332	Target Neighborhood Hits	1626	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

AIM1_HUMAN
θ value	1.06291 (rank : 225)	NC score	0.021973 (rank : 534)
Query Neighborhood Hits	332	Target Neighborhood Hits	247	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

ANM2_HUMAN
θ value	1.06291 (rank : 226)	NC score	0.287091 (rank : 130)
Query Neighborhood Hits	332	Target Neighborhood Hits	175	Shared Neighborhood Hits	144
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CSF1_HUMAN
θ value	1.06291 (rank : 227)	NC score	0.037179 (rank : 512)
Query Neighborhood Hits	332	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

GNL3_HUMAN
θ value	1.06291 (rank : 228)	NC score	0.025601 (rank : 529)
Query Neighborhood Hits	332	Target Neighborhood Hits	83	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BVP2, Q96SV6, Q96SV7, Q9UJY0	Gene names	GNL3, E2IG3, NS
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin) (E2-induced gene 3-protein) (Novel nucleolar protein 47) (NNP47).

PEX13_MOUSE
θ value	1.06291 (rank : 229)	NC score	0.360287 (rank : 106)
Query Neighborhood Hits	332	Target Neighborhood Hits	126	Shared Neighborhood Hits	114
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PTK6_MOUSE
θ value	1.06291 (rank : 230)	NC score	0.116923 (rank : 248)
Query Neighborhood Hits	332	Target Neighborhood Hits	1026	Shared Neighborhood Hits	150
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PWWP2_HUMAN
θ value	1.06291 (rank : 231)	NC score	0.045859 (rank : 490)
Query Neighborhood Hits	332	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NUJ5, Q5SZI0, Q6ZQX5, Q96F43	Gene names	PWWP2
Domain Architecture	No domain graphic available
Description	PWWP domain-containing protein 2.

REST_MOUSE
θ value	1.06291 (rank : 232)	NC score	0.044327 (rank : 496)
Query Neighborhood Hits	332	Target Neighborhood Hits	1506	Shared Neighborhood Hits	85
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

S3TC2_HUMAN
θ value	1.06291 (rank : 233)	NC score	0.076303 (rank : 340)
Query Neighborhood Hits	332	Target Neighborhood Hits	70	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

SAMN1_HUMAN
θ value	1.06291 (rank : 234)	NC score	0.170991 (rank : 190)
Query Neighborhood Hits	332	Target Neighborhood Hits	74	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

TMCC1_HUMAN
θ value	1.06291 (rank : 235)	NC score	0.033466 (rank : 515)
Query Neighborhood Hits	332	Target Neighborhood Hits	337	Shared Neighborhood Hits	36
SwissProt Accessions	O94876, Q68E06, Q8IXM8	Gene names	TMCC1, KIAA0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

ZF106_MOUSE
θ value	1.06291 (rank : 236)	NC score	0.013617 (rank : 548)
Query Neighborhood Hits	332	Target Neighborhood Hits	472	Shared Neighborhood Hits	24
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

GP179_HUMAN
θ value	1.38821 (rank : 237)	NC score	0.016066 (rank : 542)
Query Neighborhood Hits	332	Target Neighborhood Hits	372	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PRD1	Gene names	GPR179, GPR158L1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 179 precursor (Probable G-protein coupled receptor 158-like 1).

P85A_HUMAN
θ value	1.38821 (rank : 238)	NC score	0.190612 (rank : 171)
Query Neighborhood Hits	332	Target Neighborhood Hits	479	Shared Neighborhood Hits	128
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PCP2_MOUSE
θ value	1.38821 (rank : 239)	NC score	0.037763 (rank : 510)
Query Neighborhood Hits	332	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	P12660, P22941, Q3TV53	Gene names	Pcp2, Pcp-2
Domain Architecture
Description	Purkinje cell protein 2 (Protein PCD-5) (Purkinje cell-specific protein L7).

REST_HUMAN
θ value	1.38821 (rank : 240)	NC score	0.049450 (rank : 484)
Query Neighborhood Hits	332	Target Neighborhood Hits	1605	Shared Neighborhood Hits	92
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

S3TC2_MOUSE
θ value	1.38821 (rank : 241)	NC score	0.079253 (rank : 331)
Query Neighborhood Hits	332	Target Neighborhood Hits	83	Shared Neighborhood Hits	46
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

SAMN1_MOUSE
θ value	1.38821 (rank : 242)	NC score	0.163570 (rank : 200)
Query Neighborhood Hits	332	Target Neighborhood Hits	69	Shared Neighborhood Hits	48
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

STMN3_MOUSE
θ value	1.38821 (rank : 243)	NC score	0.035178 (rank : 514)
Query Neighborhood Hits	332	Target Neighborhood Hits	331	Shared Neighborhood Hits	38
SwissProt Accessions	O70166	Gene names	Stmn3, Sclip
Domain Architecture
Description	Stathmin-3 (SCG10-like protein) (SCG10-related protein HiAT3) (Hippocampus abundant transcript 3).

CD2_HUMAN
θ value	1.81305 (rank : 244)	NC score	0.025886 (rank : 528)
Query Neighborhood Hits	332	Target Neighborhood Hits	504	Shared Neighborhood Hits	26
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

EEA1_MOUSE
θ value	1.81305 (rank : 245)	NC score	0.052603 (rank : 459)
Query Neighborhood Hits	332	Target Neighborhood Hits	1637	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SRC_MOUSE
θ value	1.81305 (rank : 246)	NC score	0.135914 (rank : 222)
Query Neighborhood Hits	332	Target Neighborhood Hits	1033	Shared Neighborhood Hits	159
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TEC_HUMAN
θ value	1.81305 (rank : 247)	NC score	0.110067 (rank : 260)
Query Neighborhood Hits	332	Target Neighborhood Hits	1006	Shared Neighborhood Hits	133
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TMCC1_MOUSE
θ value	1.81305 (rank : 248)	NC score	0.030380 (rank : 518)
Query Neighborhood Hits	332	Target Neighborhood Hits	315	Shared Neighborhood Hits	32
SwissProt Accessions	Q69ZZ6, Q8CEF4	Gene names	Tmcc1, Kiaa0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

ALO17_HUMAN
θ value	2.36792 (rank : 249)	NC score	0.028817 (rank : 521)
Query Neighborhood Hits	332	Target Neighborhood Hits	317	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HCF4, Q69YK7, Q8IWF4, Q8IZX1, Q8IZX2, Q8N406	Gene names	KIAA1618, ALO17
Domain Architecture	No domain graphic available
Description	Protein ALO17 (ALK lymphoma oligomerization partner on chromosome 17).

ANM2_MOUSE
θ value	2.36792 (rank : 250)	NC score	0.273442 (rank : 135)
Query Neighborhood Hits	332	Target Neighborhood Hits	175	Shared Neighborhood Hits	138
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CN037_HUMAN
θ value	2.36792 (rank : 251)	NC score	0.017471 (rank : 540)
Query Neighborhood Hits	332	Target Neighborhood Hits	118	Shared Neighborhood Hits	7
SwissProt Accessions	Q86TY3, Q6P5Q1, Q86TY1	Gene names	C14orf37
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf37 precursor.

DCC_MOUSE
θ value	2.36792 (rank : 252)	NC score	0.003938 (rank : 558)
Query Neighborhood Hits	332	Target Neighborhood Hits	896	Shared Neighborhood Hits	30
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

EP15_HUMAN
θ value	2.36792 (rank : 253)	NC score	0.072654 (rank : 351)
Query Neighborhood Hits	332	Target Neighborhood Hits	1021	Shared Neighborhood Hits	68
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

GNL3_MOUSE
θ value	2.36792 (rank : 254)	NC score	0.027652 (rank : 523)
Query Neighborhood Hits	332	Target Neighborhood Hits	99	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CI11, Q811R9, Q811S8, Q8BK21	Gene names	Gnl3, Ns
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin).

MYH14_MOUSE
θ value	2.36792 (rank : 255)	NC score	0.055344 (rank : 438)
Query Neighborhood Hits	332	Target Neighborhood Hits	1225	Shared Neighborhood Hits	76
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

S39A6_MOUSE
θ value	2.36792 (rank : 256)	NC score	0.018543 (rank : 538)
Query Neighborhood Hits	332	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C145, Q7TPP9, Q7TQE0, Q8R518	Gene names	Slc39a6
Domain Architecture	No domain graphic available
Description	Zinc transporter SLC39A6 precursor (Solute carrier family 39 member 6) (Endoplasmic reticulum membrane-linked protein) (Ermelin).

SETD2_HUMAN
θ value	2.36792 (rank : 257)	NC score	0.021748 (rank : 535)
Query Neighborhood Hits	332	Target Neighborhood Hits	412	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

C102B_HUMAN
θ value	3.0926 (rank : 258)	NC score	0.036721 (rank : 513)
Query Neighborhood Hits	332	Target Neighborhood Hits	542	Shared Neighborhood Hits	44
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

CCNT1_HUMAN
θ value	3.0926 (rank : 259)	NC score	0.010324 (rank : 551)
Query Neighborhood Hits	332	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	O60563, O60581	Gene names	CCNT1
Domain Architecture
Description	Cyclin-T1 (CycT1) (Cyclin-T).

EVPL_MOUSE
θ value	3.0926 (rank : 260)	NC score	0.040379 (rank : 505)
Query Neighborhood Hits	332	Target Neighborhood Hits	952	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

FA47A_HUMAN
θ value	3.0926 (rank : 261)	NC score	0.037481 (rank : 511)
Query Neighborhood Hits	332	Target Neighborhood Hits	451	Shared Neighborhood Hits	35
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

HM2L1_HUMAN
θ value	3.0926 (rank : 262)	NC score	0.023579 (rank : 532)
Query Neighborhood Hits	332	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGU5, O75672, O75673, Q9UMT5	Gene names	HMG2L1, HMGBCG
Domain Architecture
Description	High mobility group protein 2-like 1 (Protein HMGBCG).

INCE_MOUSE
θ value	3.0926 (rank : 263)	NC score	0.054416 (rank : 448)
Query Neighborhood Hits	332	Target Neighborhood Hits	903	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

REV1_HUMAN
θ value	3.0926 (rank : 264)	NC score	0.015024 (rank : 546)
Query Neighborhood Hits	332	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBZ9, O95941, Q9C0J4, Q9NUP2	Gene names	REV1L, REV1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) (Alpha integrin-binding protein 80) (AIBP80).

SMCA1_MOUSE
θ value	3.0926 (rank : 265)	NC score	0.008204 (rank : 554)
Query Neighborhood Hits	332	Target Neighborhood Hits	117	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PGB8, Q8BSS1, Q91Y58	Gene names	Smarca1, Snf2l
Domain Architecture	No domain graphic available
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) (DNA-dependent ATPase SNF2L).

SON_MOUSE
θ value	3.0926 (rank : 266)	NC score	0.028357 (rank : 522)
Query Neighborhood Hits	332	Target Neighborhood Hits	957	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

ABL1_MOUSE
θ value	4.03905 (rank : 267)	NC score	0.109624 (rank : 262)
Query Neighborhood Hits	332	Target Neighborhood Hits	1178	Shared Neighborhood Hits	140
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

APOE_MOUSE
θ value	4.03905 (rank : 268)	NC score	0.045319 (rank : 492)
Query Neighborhood Hits	332	Target Neighborhood Hits	319	Shared Neighborhood Hits	40
SwissProt Accessions	P08226	Gene names	Apoe
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

CCD27_MOUSE
θ value	4.03905 (rank : 269)	NC score	0.044019 (rank : 498)
Query Neighborhood Hits	332	Target Neighborhood Hits	461	Shared Neighborhood Hits	46
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CD45_HUMAN
θ value	4.03905 (rank : 270)	NC score	0.005017 (rank : 557)
Query Neighborhood Hits	332	Target Neighborhood Hits	243	Shared Neighborhood Hits	11
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CENPF_HUMAN
θ value	4.03905 (rank : 271)	NC score	0.051834 (rank : 465)
Query Neighborhood Hits	332	Target Neighborhood Hits	1932	Shared Neighborhood Hits	109
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

INCE_HUMAN
θ value	4.03905 (rank : 272)	NC score	0.055614 (rank : 436)
Query Neighborhood Hits	332	Target Neighborhood Hits	978	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

LCK_HUMAN
θ value	4.03905 (rank : 273)	NC score	0.109876 (rank : 261)
Query Neighborhood Hits	332	Target Neighborhood Hits	987	Shared Neighborhood Hits	117
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	4.03905 (rank : 274)	NC score	0.109002 (rank : 267)
Query Neighborhood Hits	332	Target Neighborhood Hits	981	Shared Neighborhood Hits	117
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LYN_MOUSE
θ value	4.03905 (rank : 275)	NC score	0.128604 (rank : 234)
Query Neighborhood Hits	332	Target Neighborhood Hits	1023	Shared Neighborhood Hits	150
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MLL3_HUMAN
θ value	4.03905 (rank : 276)	NC score	0.039729 (rank : 508)
Query Neighborhood Hits	332	Target Neighborhood Hits	1644	Shared Neighborhood Hits	81
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NUMA1_HUMAN
θ value	4.03905 (rank : 277)	NC score	0.048175 (rank : 486)
Query Neighborhood Hits	332	Target Neighborhood Hits	1523	Shared Neighborhood Hits	92
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RHG25_MOUSE
θ value	4.03905 (rank : 278)	NC score	0.072374 (rank : 353)
Query Neighborhood Hits	332	Target Neighborhood Hits	492	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TEC_MOUSE
θ value	4.03905 (rank : 279)	NC score	0.106067 (rank : 273)
Query Neighborhood Hits	332	Target Neighborhood Hits	1006	Shared Neighborhood Hits	134
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TRI39_MOUSE
θ value	4.03905 (rank : 280)	NC score	0.011882 (rank : 549)
Query Neighborhood Hits	332	Target Neighborhood Hits	691	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

AFF2_HUMAN
θ value	5.27518 (rank : 281)	NC score	0.039407 (rank : 509)
Query Neighborhood Hits	332	Target Neighborhood Hits	218	Shared Neighborhood Hits	21
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

CSKI1_HUMAN
θ value	5.27518 (rank : 282)	NC score	0.055124 (rank : 441)
Query Neighborhood Hits	332	Target Neighborhood Hits	997	Shared Neighborhood Hits	86
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	5.27518 (rank : 283)	NC score	0.052359 (rank : 461)
Query Neighborhood Hits	332	Target Neighborhood Hits	1031	Shared Neighborhood Hits	79
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

JIP1_HUMAN
θ value	5.27518 (rank : 284)	NC score	0.120894 (rank : 245)
Query Neighborhood Hits	332	Target Neighborhood Hits	271	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	5.27518 (rank : 285)	NC score	0.119907 (rank : 246)
Query Neighborhood Hits	332	Target Neighborhood Hits	259	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LBXCO_HUMAN
θ value	5.27518 (rank : 286)	NC score	0.025888 (rank : 527)
Query Neighborhood Hits	332	Target Neighborhood Hits	167	Shared Neighborhood Hits	18
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

LBXCO_MOUSE
θ value	5.27518 (rank : 287)	NC score	0.026382 (rank : 525)
Query Neighborhood Hits	332	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

LIPA2_MOUSE
θ value	5.27518 (rank : 288)	NC score	0.046268 (rank : 488)
Query Neighborhood Hits	332	Target Neighborhood Hits	1282	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

MYH8_HUMAN
θ value	5.27518 (rank : 289)	NC score	0.060748 (rank : 394)
Query Neighborhood Hits	332	Target Neighborhood Hits	1610	Shared Neighborhood Hits	99
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH9_HUMAN
θ value	5.27518 (rank : 290)	NC score	0.063007 (rank : 386)
Query Neighborhood Hits	332	Target Neighborhood Hits	1762	Shared Neighborhood Hits	105
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RFIP4_HUMAN
θ value	5.27518 (rank : 291)	NC score	0.043271 (rank : 499)
Query Neighborhood Hits	332	Target Neighborhood Hits	785	Shared Neighborhood Hits	62
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

S23IP_MOUSE
θ value	5.27518 (rank : 292)	NC score	0.021678 (rank : 536)
Query Neighborhood Hits	332	Target Neighborhood Hits	363	Shared Neighborhood Hits	26
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

SMCA5_MOUSE
θ value	5.27518 (rank : 293)	NC score	0.009551 (rank : 552)
Query Neighborhood Hits	332	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZW3, Q8C791, Q8CA22, Q8VDG1, Q925M9	Gene names	Smarca5, Snf2h
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.1.-) (Sucrose nonfermenting protein 2 homolog) (mSnf2h).

TRHY_HUMAN
θ value	5.27518 (rank : 294)	NC score	0.045930 (rank : 489)
Query Neighborhood Hits	332	Target Neighborhood Hits	1385	Shared Neighborhood Hits	84
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

ZP1_MOUSE
θ value	5.27518 (rank : 295)	NC score	0.007946 (rank : 555)
Query Neighborhood Hits	332	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q62005, Q62016	Gene names	Zp1
Domain Architecture
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

ABL1_HUMAN
θ value	6.88961 (rank : 296)	NC score	0.109188 (rank : 266)
Query Neighborhood Hits	332	Target Neighborhood Hits	1220	Shared Neighborhood Hits	138
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BSN_HUMAN
θ value	6.88961 (rank : 297)	NC score	0.031891 (rank : 516)
Query Neighborhood Hits	332	Target Neighborhood Hits	1537	Shared Neighborhood Hits	95
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CIZ1_HUMAN
θ value	6.88961 (rank : 298)	NC score	0.029790 (rank : 519)
Query Neighborhood Hits	332	Target Neighborhood Hits	359	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

CJ012_HUMAN
θ value	6.88961 (rank : 299)	NC score	0.018441 (rank : 539)
Query Neighborhood Hits	332	Target Neighborhood Hits	467	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CP135_HUMAN
θ value	6.88961 (rank : 300)	NC score	0.045697 (rank : 491)
Query Neighborhood Hits	332	Target Neighborhood Hits	1290	Shared Neighborhood Hits	82
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

HCK_HUMAN
θ value	6.88961 (rank : 301)	NC score	0.137780 (rank : 221)
Query Neighborhood Hits	332	Target Neighborhood Hits	1035	Shared Neighborhood Hits	164
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HOME2_MOUSE
θ value	6.88961 (rank : 302)	NC score	0.044150 (rank : 497)
Query Neighborhood Hits	332	Target Neighborhood Hits	882	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

IF2P_HUMAN
θ value	6.88961 (rank : 303)	NC score	0.041436 (rank : 502)
Query Neighborhood Hits	332	Target Neighborhood Hits	889	Shared Neighborhood Hits	70
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

IL3B2_MOUSE
θ value	6.88961 (rank : 304)	NC score	0.010875 (rank : 550)
Query Neighborhood Hits	332	Target Neighborhood Hits	372	Shared Neighborhood Hits	17
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

MACOI_MOUSE
θ value	6.88961 (rank : 305)	NC score	0.043036 (rank : 500)
Query Neighborhood Hits	332	Target Neighborhood Hits	620	Shared Neighborhood Hits	58
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MAP1B_MOUSE
θ value	6.88961 (rank : 306)	NC score	0.042345 (rank : 501)
Query Neighborhood Hits	332	Target Neighborhood Hits	977	Shared Neighborhood Hits	77
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MAP2_MOUSE
θ value	6.88961 (rank : 307)	NC score	0.015882 (rank : 543)
Query Neighborhood Hits	332	Target Neighborhood Hits	342	Shared Neighborhood Hits	28
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

MPP3_HUMAN
θ value	6.88961 (rank : 308)	NC score	0.084331 (rank : 317)
Query Neighborhood Hits	332	Target Neighborhood Hits	171	Shared Neighborhood Hits	38
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MY18B_HUMAN
θ value	6.88961 (rank : 309)	NC score	0.056431 (rank : 428)
Query Neighborhood Hits	332	Target Neighborhood Hits	1299	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYH1_MOUSE
θ value	6.88961 (rank : 310)	NC score	0.060888 (rank : 393)
Query Neighborhood Hits	332	Target Neighborhood Hits	1461	Shared Neighborhood Hits	90
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH4_MOUSE
θ value	6.88961 (rank : 311)	NC score	0.058334 (rank : 415)
Query Neighborhood Hits	332	Target Neighborhood Hits	1476	Shared Neighborhood Hits	94
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

NFH_HUMAN
θ value	6.88961 (rank : 312)	NC score	0.020313 (rank : 537)
Query Neighborhood Hits	332	Target Neighborhood Hits	1242	Shared Neighborhood Hits	86
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NOG1_HUMAN
θ value	6.88961 (rank : 313)	NC score	0.022415 (rank : 533)
Query Neighborhood Hits	332	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BZE4, O95446, Q9NVJ8	Gene names	GTPBP4, CRFG, NOG1
Domain Architecture
Description	Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB).

PCNT_HUMAN
θ value	6.88961 (rank : 314)	NC score	0.052768 (rank : 456)
Query Neighborhood Hits	332	Target Neighborhood Hits	1551	Shared Neighborhood Hits	102
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

RUSC1_HUMAN
θ value	6.88961 (rank : 315)	NC score	0.283912 (rank : 133)
Query Neighborhood Hits	332	Target Neighborhood Hits	226	Shared Neighborhood Hits	137
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

TXK_MOUSE
θ value	6.88961 (rank : 316)	NC score	0.114774 (rank : 252)
Query Neighborhood Hits	332	Target Neighborhood Hits	980	Shared Neighborhood Hits	140
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ANK1_HUMAN
θ value	8.99809 (rank : 317)	NC score	0.026107 (rank : 526)
Query Neighborhood Hits	332	Target Neighborhood Hits	416	Shared Neighborhood Hits	21
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

CSKI2_HUMAN
θ value	8.99809 (rank : 318)	NC score	0.054810 (rank : 445)
Query Neighborhood Hits	332	Target Neighborhood Hits	747	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	8.99809 (rank : 319)	NC score	0.059117 (rank : 409)
Query Neighborhood Hits	332	Target Neighborhood Hits	812	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DLG2_MOUSE
θ value	8.99809 (rank : 320)	NC score	0.079937 (rank : 328)
Query Neighborhood Hits	332	Target Neighborhood Hits	271	Shared Neighborhood Hits	77
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

EP15_MOUSE
θ value	8.99809 (rank : 321)	NC score	0.073752 (rank : 349)
Query Neighborhood Hits	332	Target Neighborhood Hits	820	Shared Neighborhood Hits	60
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

KIF3A_HUMAN
θ value	8.99809 (rank : 322)	NC score	0.014378 (rank : 547)
Query Neighborhood Hits	332	Target Neighborhood Hits	704	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3A_MOUSE
θ value	8.99809 (rank : 323)	NC score	0.015499 (rank : 544)
Query Neighborhood Hits	332	Target Neighborhood Hits	715	Shared Neighborhood Hits	57
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

MACOI_HUMAN
θ value	8.99809 (rank : 324)	NC score	0.044551 (rank : 495)
Query Neighborhood Hits	332	Target Neighborhood Hits	650	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MYH1_HUMAN
θ value	8.99809 (rank : 325)	NC score	0.058641 (rank : 412)
Query Neighborhood Hits	332	Target Neighborhood Hits	1478	Shared Neighborhood Hits	90
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH3_HUMAN
θ value	8.99809 (rank : 326)	NC score	0.060090 (rank : 400)
Query Neighborhood Hits	332	Target Neighborhood Hits	1660	Shared Neighborhood Hits	98
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH4_HUMAN
θ value	8.99809 (rank : 327)	NC score	0.054702 (rank : 446)
Query Neighborhood Hits	332	Target Neighborhood Hits	1377	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

NCOR1_HUMAN
θ value	8.99809 (rank : 328)	NC score	0.016367 (rank : 541)
Query Neighborhood Hits	332	Target Neighborhood Hits	577	Shared Neighborhood Hits	38
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

PDZD2_HUMAN
θ value	8.99809 (rank : 329)	NC score	0.025252 (rank : 530)
Query Neighborhood Hits	332	Target Neighborhood Hits	772	Shared Neighborhood Hits	49
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SMCA1_HUMAN
θ value	8.99809 (rank : 330)	NC score	0.007193 (rank : 556)
Query Neighborhood Hits	332	Target Neighborhood Hits	105	Shared Neighborhood Hits	12
SwissProt Accessions	P28370, Q5JV41, Q5JV42	Gene names	SMARCA1, SNF2L, SNF2L1
Domain Architecture
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1).

SMCA5_HUMAN
θ value	8.99809 (rank : 331)	NC score	0.009082 (rank : 553)
Query Neighborhood Hits	332	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	O60264	Gene names	SMARCA5, SNF2H, WCRF135
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.1.-) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin A5) (Sucrose nonfermenting protein 2 homolog) (hSNF2H).

WDR67_MOUSE
θ value	8.99809 (rank : 332)	NC score	0.024707 (rank : 531)
Query Neighborhood Hits	332	Target Neighborhood Hits	476	Shared Neighborhood Hits	42
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

3BP1_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.078420 (rank : 332)
Query Neighborhood Hits	332	Target Neighborhood Hits	376	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

3BP1_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.055796 (rank : 432)
Query Neighborhood Hits	332	Target Neighborhood Hits	238	Shared Neighborhood Hits	33
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABL2_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.102948 (rank : 280)
Query Neighborhood Hits	332	Target Neighborhood Hits	1045	Shared Neighborhood Hits	120
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABR_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.106448 (rank : 272)
Query Neighborhood Hits	332	Target Neighborhood Hits	166	Shared Neighborhood Hits	37
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

APS_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.105930 (rank : 274)
Query Neighborhood Hits	332	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.082473 (rank : 320)
Query Neighborhood Hits	332	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.125594 (rank : 238)
Query Neighborhood Hits	332	Target Neighborhood Hits	176	Shared Neighborhood Hits	23
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.109333 (rank : 264)
Query Neighborhood Hits	332	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.109358 (rank : 263)
Query Neighborhood Hits	332	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.107416 (rank : 269)
Query Neighborhood Hits	332	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.176767 (rank : 180)
Query Neighborhood Hits	332	Target Neighborhood Hits	82	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.176365 (rank : 181)
Query Neighborhood Hits	332	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.160976 (rank : 202)
Query Neighborhood Hits	332	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.174080 (rank : 185)
Query Neighborhood Hits	332	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.139923 (rank : 219)
Query Neighborhood Hits	332	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.144297 (rank : 214)
Query Neighborhood Hits	332	Target Neighborhood Hits	125	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.127404 (rank : 235)
Query Neighborhood Hits	332	Target Neighborhood Hits	375	Shared Neighborhood Hits	40
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.126368 (rank : 236)
Query Neighborhood Hits	332	Target Neighborhood Hits	351	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.125473 (rank : 239)
Query Neighborhood Hits	332	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.140361 (rank : 217)
Query Neighborhood Hits	332	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

BCAR3_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.075833 (rank : 343)
Query Neighborhood Hits	332	Target Neighborhood Hits	129	Shared Neighborhood Hits	37
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.073783 (rank : 348)
Query Neighborhood Hits	332	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.121155 (rank : 244)
Query Neighborhood Hits	332	Target Neighborhood Hits	204	Shared Neighborhood Hits	37
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.158010 (rank : 204)
Query Neighborhood Hits	332	Target Neighborhood Hits	197	Shared Neighborhood Hits	65
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN3_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.050216 (rank : 481)
Query Neighborhood Hits	332	Target Neighborhood Hits	165	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JI08	Gene names	Bin3
Domain Architecture	No domain graphic available
Description	Bridging integrator 3.

BLNK_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.064327 (rank : 381)
Query Neighborhood Hits	332	Target Neighborhood Hits	228	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.077277 (rank : 336)
Query Neighborhood Hits	332	Target Neighborhood Hits	296	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMX_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.057287 (rank : 423)
Query Neighborhood Hits	332	Target Neighborhood Hits	942	Shared Neighborhood Hits	55
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.057253 (rank : 424)
Query Neighborhood Hits	332	Target Neighborhood Hits	912	Shared Neighborhood Hits	53
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CCD46_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.052638 (rank : 458)
Query Neighborhood Hits	332	Target Neighborhood Hits	1430	Shared Neighborhood Hits	93
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CEP63_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.050353 (rank : 478)
Query Neighborhood Hits	332	Target Neighborhood Hits	1005	Shared Neighborhood Hits	77
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CHIN_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.098932 (rank : 295)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.101004 (rank : 287)
Query Neighborhood Hits	332	Target Neighborhood Hits	229	Shared Neighborhood Hits	52
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.096724 (rank : 299)
Query Neighborhood Hits	332	Target Neighborhood Hits	220	Shared Neighborhood Hits	47
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.067393 (rank : 365)
Query Neighborhood Hits	332	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CI093_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.050268 (rank : 480)
Query Neighborhood Hits	332	Target Neighborhood Hits	1088	Shared Neighborhood Hits	78
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CIP4_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.164500 (rank : 196)
Query Neighborhood Hits	332	Target Neighborhood Hits	374	Shared Neighborhood Hits	103
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CP250_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.050210 (rank : 482)
Query Neighborhood Hits	332	Target Neighborhood Hits	1805	Shared Neighborhood Hits	92
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CSK_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.114142 (rank : 254)
Query Neighborhood Hits	332	Target Neighborhood Hits	1009	Shared Neighborhood Hits	134
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.114104 (rank : 255)
Query Neighborhood Hits	332	Target Neighborhood Hits	1009	Shared Neighborhood Hits	134
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPP1_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.129613 (rank : 233)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.131951 (rank : 230)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDFL1_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.059890 (rank : 404)
Query Neighborhood Hits	332	Target Neighborhood Hits	353	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.057442 (rank : 421)
Query Neighborhood Hits	332	Target Neighborhood Hits	324	Shared Neighborhood Hits	19
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DLG1_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.071561 (rank : 356)
Query Neighborhood Hits	332	Target Neighborhood Hits	290	Shared Neighborhood Hits	73
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.068322 (rank : 363)
Query Neighborhood Hits	332	Target Neighborhood Hits	285	Shared Neighborhood Hits	72
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG2_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.077195 (rank : 337)
Query Neighborhood Hits	332	Target Neighborhood Hits	279	Shared Neighborhood Hits	77
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.072485 (rank : 352)
Query Neighborhood Hits	332	Target Neighborhood Hits	269	Shared Neighborhood Hits	75
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.071737 (rank : 355)
Query Neighborhood Hits	332	Target Neighborhood Hits	274	Shared Neighborhood Hits	75
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG4_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.068755 (rank : 361)
Query Neighborhood Hits	332	Target Neighborhood Hits	286	Shared Neighborhood Hits	74
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.066511 (rank : 372)
Query Neighborhood Hits	332	Target Neighborhood Hits	282	Shared Neighborhood Hits	72
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG5_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.059893 (rank : 403)
Query Neighborhood Hits	332	Target Neighborhood Hits	1088	Shared Neighborhood Hits	112
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DOCK2_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.056043 (rank : 430)
Query Neighborhood Hits	332	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.059286 (rank : 408)
Query Neighborhood Hits	332	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DUET_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.060571 (rank : 395)
Query Neighborhood Hits	332	Target Neighborhood Hits	1220	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ECT2_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.135744 (rank : 223)
Query Neighborhood Hits	332	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.140103 (rank : 218)
Query Neighborhood Hits	332	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ENAH_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.051023 (rank : 469)
Query Neighborhood Hits	332	Target Neighborhood Hits	919	Shared Neighborhood Hits	72
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EP15R_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.064076 (rank : 383)
Query Neighborhood Hits	332	Target Neighborhood Hits	1083	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.069578 (rank : 360)
Query Neighborhood Hits	332	Target Neighborhood Hits	1135	Shared Neighborhood Hits	75
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

ES8L1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.193118 (rank : 168)
Query Neighborhood Hits	332	Target Neighborhood Hits	162	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.191599 (rank : 170)
Query Neighborhood Hits	332	Target Neighborhood Hits	143	Shared Neighborhood Hits	93
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FARP1_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.084304 (rank : 318)
Query Neighborhood Hits	332	Target Neighborhood Hits	241	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.085220 (rank : 316)
Query Neighborhood Hits	332	Target Neighborhood Hits	240	Shared Neighborhood Hits	30
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.094025 (rank : 303)
Query Neighborhood Hits	332	Target Neighborhood Hits	209	Shared Neighborhood Hits	32
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.067317 (rank : 366)
Query Neighborhood Hits	332	Target Neighborhood Hits	1278	Shared Neighborhood Hits	109
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGD1_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.100219 (rank : 289)
Query Neighborhood Hits	332	Target Neighborhood Hits	367	Shared Neighborhood Hits	43
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.097057 (rank : 298)
Query Neighborhood Hits	332	Target Neighborhood Hits	387	Shared Neighborhood Hits	42
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.110256 (rank : 259)
Query Neighborhood Hits	332	Target Neighborhood Hits	151	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.103669 (rank : 278)
Query Neighborhood Hits	332	Target Neighborhood Hits	163	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.107401 (rank : 270)
Query Neighborhood Hits	332	Target Neighborhood Hits	249	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.114805 (rank : 251)
Query Neighborhood Hits	332	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.114295 (rank : 253)
Query Neighborhood Hits	332	Target Neighborhood Hits	219	Shared Neighborhood Hits	33
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.115271 (rank : 250)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	33
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.081187 (rank : 325)
Query Neighborhood Hits	332	Target Neighborhood Hits	237	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.091476 (rank : 307)
Query Neighborhood Hits	332	Target Neighborhood Hits	282	Shared Neighborhood Hits	38
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FLIP1_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.051607 (rank : 467)
Query Neighborhood Hits	332	Target Neighborhood Hits	1405	Shared Neighborhood Hits	92
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FYB_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.050526 (rank : 475)
Query Neighborhood Hits	332	Target Neighborhood Hits	194	Shared Neighborhood Hits	34
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GAS7_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.052949 (rank : 453)
Query Neighborhood Hits	332	Target Neighborhood Hits	258	Shared Neighborhood Hits	40
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GNRP_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.105877 (rank : 275)
Query Neighborhood Hits	332	Target Neighborhood Hits	239	Shared Neighborhood Hits	35
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.116368 (rank : 249)
Query Neighborhood Hits	332	Target Neighborhood Hits	191	Shared Neighborhood Hits	31
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.077292 (rank : 335)
Query Neighborhood Hits	332	Target Neighborhood Hits	147	Shared Neighborhood Hits	44
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.078107 (rank : 334)
Query Neighborhood Hits	332	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.098645 (rank : 296)
Query Neighborhood Hits	332	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.099017 (rank : 294)
Query Neighborhood Hits	332	Target Neighborhood Hits	149	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.080751 (rank : 326)
Query Neighborhood Hits	332	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.090330 (rank : 308)
Query Neighborhood Hits	332	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.122369 (rank : 241)
Query Neighborhood Hits	332	Target Neighborhood Hits	350	Shared Neighborhood Hits	61
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HCK_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.138245 (rank : 220)
Query Neighborhood Hits	332	Target Neighborhood Hits	1029	Shared Neighborhood Hits	165
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HGS_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.054173 (rank : 449)
Query Neighborhood Hits	332	Target Neighborhood Hits	517	Shared Neighborhood Hits	43
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.052145 (rank : 462)
Query Neighborhood Hits	332	Target Neighborhood Hits	589	Shared Neighborhood Hits	46
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HSH2D_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.090063 (rank : 310)
Query Neighborhood Hits	332	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.066101 (rank : 373)
Query Neighborhood Hits	332	Target Neighborhood Hits	124	Shared Neighborhood Hits	27
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ILK1_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.055740 (rank : 434)
Query Neighborhood Hits	332	Target Neighborhood Hits	857	Shared Neighborhood Hits	50
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.055457 (rank : 437)
Query Neighborhood Hits	332	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.055698 (rank : 435)
Query Neighborhood Hits	332	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ITK_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.097929 (rank : 297)
Query Neighborhood Hits	332	Target Neighborhood Hits	1016	Shared Neighborhood Hits	128
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.090196 (rank : 309)
Query Neighborhood Hits	332	Target Neighborhood Hits	985	Shared Neighborhood Hits	114
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KGUA_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.050351 (rank : 479)
Query Neighborhood Hits	332	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KSYK_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.058441 (rank : 414)
Query Neighborhood Hits	332	Target Neighborhood Hits	901	Shared Neighborhood Hits	56
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.060034 (rank : 401)
Query Neighborhood Hits	332	Target Neighborhood Hits	944	Shared Neighborhood Hits	59
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.112632 (rank : 258)
Query Neighborhood Hits	332	Target Neighborhood Hits	90	Shared Neighborhood Hits	23
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.089298 (rank : 312)
Query Neighborhood Hits	332	Target Neighborhood Hits	531	Shared Neighborhood Hits	63
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.095697 (rank : 301)
Query Neighborhood Hits	332	Target Neighborhood Hits	177	Shared Neighborhood Hits	47
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LMO7_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.054974 (rank : 443)
Query Neighborhood Hits	332	Target Neighborhood Hits	507	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LNK_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.096163 (rank : 300)
Query Neighborhood Hits	332	Target Neighborhood Hits	151	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.095544 (rank : 302)
Query Neighborhood Hits	332	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MATK_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.071373 (rank : 357)
Query Neighborhood Hits	332	Target Neighborhood Hits	954	Shared Neighborhood Hits	76
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.073431 (rank : 350)
Query Neighborhood Hits	332	Target Neighborhood Hits	952	Shared Neighborhood Hits	83
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.173859 (rank : 186)
Query Neighborhood Hits	332	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.143878 (rank : 215)
Query Neighborhood Hits	332	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MDC1_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.059966 (rank : 402)
Query Neighborhood Hits	332	Target Neighborhood Hits	1446	Shared Neighborhood Hits	89
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MPP3_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.082346 (rank : 321)
Query Neighborhood Hits	332	Target Neighborhood Hits	165	Shared Neighborhood Hits	37
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP4_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.091731 (rank : 305)
Query Neighborhood Hits	332	Target Neighborhood Hits	205	Shared Neighborhood Hits	62
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.102376 (rank : 281)
Query Neighborhood Hits	332	Target Neighborhood Hits	188	Shared Neighborhood Hits	65
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MUC7_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.050544 (rank : 473)
Query Neighborhood Hits	332	Target Neighborhood Hits	538	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MY18A_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.065631 (rank : 376)
Query Neighborhood Hits	332	Target Neighborhood Hits	1929	Shared Neighborhood Hits	112
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.063427 (rank : 385)
Query Neighborhood Hits	332	Target Neighborhood Hits	1989	Shared Neighborhood Hits	110
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH10_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.057533 (rank : 420)
Query Neighborhood Hits	332	Target Neighborhood Hits	1620	Shared Neighborhood Hits	98
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.057659 (rank : 419)
Query Neighborhood Hits	332	Target Neighborhood Hits	1612	Shared Neighborhood Hits	98
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH11_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.061902 (rank : 389)
Query Neighborhood Hits	332	Target Neighborhood Hits	1777	Shared Neighborhood Hits	109
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH13_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.056971 (rank : 425)
Query Neighborhood Hits	332	Target Neighborhood Hits	1504	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH2_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.057904 (rank : 417)
Query Neighborhood Hits	332	Target Neighborhood Hits	1491	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH6_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.052864 (rank : 455)
Query Neighborhood Hits	332	Target Neighborhood Hits	1426	Shared Neighborhood Hits	83
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.054590 (rank : 447)
Query Neighborhood Hits	332	Target Neighborhood Hits	1501	Shared Neighborhood Hits	89
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.053718 (rank : 450)
Query Neighborhood Hits	332	Target Neighborhood Hits	1559	Shared Neighborhood Hits	87
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH8_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.058855 (rank : 410)
Query Neighborhood Hits	332	Target Neighborhood Hits	1600	Shared Neighborhood Hits	94
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH9_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.061914 (rank : 388)
Query Neighborhood Hits	332	Target Neighborhood Hits	1829	Shared Neighborhood Hits	114
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYO10_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.055759 (rank : 433)
Query Neighborhood Hits	332	Target Neighborhood Hits	920	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYO15_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.052679 (rank : 457)
Query Neighborhood Hits	332	Target Neighborhood Hits	671	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO15_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.056882 (rank : 426)
Query Neighborhood Hits	332	Target Neighborhood Hits	467	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO5A_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.052897 (rank : 454)
Query Neighborhood Hits	332	Target Neighborhood Hits	1092	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MYO5A_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.050404 (rank : 476)
Query Neighborhood Hits	332	Target Neighborhood Hits	1117	Shared Neighborhood Hits	74
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5C_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.056824 (rank : 427)
Query Neighborhood Hits	332	Target Neighborhood Hits	1206	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYO6_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.052001 (rank : 464)
Query Neighborhood Hits	332	Target Neighborhood Hits	727	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO6_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.052477 (rank : 460)
Query Neighborhood Hits	332	Target Neighborhood Hits	586	Shared Neighborhood Hits	47
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO7A_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.050389 (rank : 477)
Query Neighborhood Hits	332	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO9B_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.060334 (rank : 398)
Query Neighborhood Hits	332	Target Neighborhood Hits	641	Shared Neighborhood Hits	49
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.060565 (rank : 396)
Query Neighborhood Hits	332	Target Neighborhood Hits	311	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

OPHN1_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.066604 (rank : 371)
Query Neighborhood Hits	332	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.064135 (rank : 382)
Query Neighborhood Hits	332	Target Neighborhood Hits	174	Shared Neighborhood Hits	26
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

P55G_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.125690 (rank : 237)
Query Neighborhood Hits	332	Target Neighborhood Hits	451	Shared Neighborhood Hits	86
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.122361 (rank : 242)
Query Neighborhood Hits	332	Target Neighborhood Hits	401	Shared Neighborhood Hits	80
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.155502 (rank : 207)
Query Neighborhood Hits	332	Target Neighborhood Hits	543	Shared Neighborhood Hits	116
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.147931 (rank : 210)
Query Neighborhood Hits	332	Target Neighborhood Hits	519	Shared Neighborhood Hits	113
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCLO_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.065046 (rank : 379)
Query Neighborhood Hits	332	Target Neighborhood Hits	2046	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PEX13_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.338324 (rank : 108)
Query Neighborhood Hits	332	Target Neighborhood Hits	128	Shared Neighborhood Hits	109
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHG1_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.187647 (rank : 175)
Query Neighborhood Hits	332	Target Neighborhood Hits	174	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.088922 (rank : 313)
Query Neighborhood Hits	332	Target Neighborhood Hits	200	Shared Neighborhood Hits	25
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCB1_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.056015 (rank : 431)
Query Neighborhood Hits	332	Target Neighborhood Hits	614	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB1_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.050565 (rank : 472)
Query Neighborhood Hits	332	Target Neighborhood Hits	531	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB2_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.055237 (rank : 439)
Query Neighborhood Hits	332	Target Neighborhood Hits	608	Shared Neighborhood Hits	56
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLCB3_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.056175 (rank : 429)
Query Neighborhood Hits	332	Target Neighborhood Hits	445	Shared Neighborhood Hits	49
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCB4_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.060414 (rank : 397)
Query Neighborhood Hits	332	Target Neighborhood Hits	658	Shared Neighborhood Hits	58
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PLCD1_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.052093 (rank : 463)
Query Neighborhood Hits	332	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PPIP2_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.099256 (rank : 293)
Query Neighborhood Hits	332	Target Neighborhood Hits	254	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.093721 (rank : 304)
Query Neighborhood Hits	332	Target Neighborhood Hits	308	Shared Neighborhood Hits	45
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.178122 (rank : 179)
Query Neighborhood Hits	332	Target Neighborhood Hits	177	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTN11_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.079317 (rank : 330)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.079322 (rank : 329)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.065990 (rank : 374)
Query Neighborhood Hits	332	Target Neighborhood Hits	234	Shared Neighborhood Hits	51
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.067156 (rank : 367)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.142704 (rank : 216)
Query Neighborhood Hits	332	Target Neighborhood Hits	258	Shared Neighborhood Hits	71
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RBP1_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.053633 (rank : 451)
Query Neighborhood Hits	332	Target Neighborhood Hits	521	Shared Neighborhood Hits	56
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.053377 (rank : 452)
Query Neighborhood Hits	332	Target Neighborhood Hits	493	Shared Neighborhood Hits	58
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

REPS1_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.064331 (rank : 380)
Query Neighborhood Hits	332	Target Neighborhood Hits	205	Shared Neighborhood Hits	26
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.061409 (rank : 391)
Query Neighborhood Hits	332	Target Neighborhood Hits	204	Shared Neighborhood Hits	22
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.070648 (rank : 358)
Query Neighborhood Hits	332	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.070639 (rank : 359)
Query Neighborhood Hits	332	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGAP1_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.051739 (rank : 466)
Query Neighborhood Hits	332	Target Neighborhood Hits	185	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGNEF_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.119163 (rank : 247)
Query Neighborhood Hits	332	Target Neighborhood Hits	641	Shared Neighborhood Hits	72
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG09_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.082193 (rank : 322)
Query Neighborhood Hits	332	Target Neighborhood Hits	186	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.076504 (rank : 339)
Query Neighborhood Hits	332	Target Neighborhood Hits	190	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.086034 (rank : 315)
Query Neighborhood Hits	332	Target Neighborhood Hits	204	Shared Neighborhood Hits	55
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RUSC1_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.248735 (rank : 149)
Query Neighborhood Hits	332	Target Neighborhood Hits	206	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.106725 (rank : 271)
Query Neighborhood Hits	332	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.089437 (rank : 311)
Query Neighborhood Hits	332	Target Neighborhood Hits	305	Shared Neighborhood Hits	74
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

S3TC1_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.050894 (rank : 470)
Query Neighborhood Hits	332	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

SH21A_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.076162 (rank : 342)
Query Neighborhood Hits	332	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.075537 (rank : 344)
Query Neighborhood Hits	332	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.100442 (rank : 288)
Query Neighborhood Hits	332	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.102952 (rank : 279)
Query Neighborhood Hits	332	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.074872 (rank : 347)
Query Neighborhood Hits	332	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.081298 (rank : 324)
Query Neighborhood Hits	332	Target Neighborhood Hits	179	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.066613 (rank : 370)
Query Neighborhood Hits	332	Target Neighborhood Hits	149	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.091483 (rank : 306)
Query Neighborhood Hits	332	Target Neighborhood Hits	455	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.062756 (rank : 387)
Query Neighborhood Hits	332	Target Neighborhood Hits	326	Shared Neighborhood Hits	56
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.076212 (rank : 341)
Query Neighborhood Hits	332	Target Neighborhood Hits	188	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.081404 (rank : 323)
Query Neighborhood Hits	332	Target Neighborhood Hits	174	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.101653 (rank : 283)
Query Neighborhood Hits	332	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.104944 (rank : 276)
Query Neighborhood Hits	332	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.101638 (rank : 284)
Query Neighborhood Hits	332	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.102164 (rank : 282)
Query Neighborhood Hits	332	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.099515 (rank : 292)
Query Neighborhood Hits	332	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.099530 (rank : 291)
Query Neighborhood Hits	332	Target Neighborhood Hits	144	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.101050 (rank : 286)
Query Neighborhood Hits	332	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.107862 (rank : 268)
Query Neighborhood Hits	332	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.100211 (rank : 290)
Query Neighborhood Hits	332	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.101626 (rank : 285)
Query Neighborhood Hits	332	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.109249 (rank : 265)
Query Neighborhood Hits	332	Target Neighborhood Hits	164	Shared Neighborhood Hits	47
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.114028 (rank : 256)
Query Neighborhood Hits	332	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB2_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.233639 (rank : 158)
Query Neighborhood Hits	332	Target Neighborhood Hits	86	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.233487 (rank : 159)
Query Neighborhood Hits	332	Target Neighborhood Hits	88	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.145636 (rank : 211)
Query Neighborhood Hits	332	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.144710 (rank : 213)
Query Neighborhood Hits	332	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.163729 (rank : 199)
Query Neighborhood Hits	332	Target Neighborhood Hits	139	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.161075 (rank : 201)
Query Neighborhood Hits	332	Target Neighborhood Hits	136	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SOCS2_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.054940 (rank : 444)
Query Neighborhood Hits	332	Target Neighborhood Hits	104	Shared Neighborhood Hits	32
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.057956 (rank : 416)
Query Neighborhood Hits	332	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.058600 (rank : 413)
Query Neighborhood Hits	332	Target Neighborhood Hits	126	Shared Neighborhood Hits	33
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.058711 (rank : 411)
Query Neighborhood Hits	332	Target Neighborhood Hits	146	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.068531 (rank : 362)
Query Neighborhood Hits	332	Target Neighborhood Hits	154	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOS1_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.066885 (rank : 369)
Query Neighborhood Hits	332	Target Neighborhood Hits	274	Shared Neighborhood Hits	31
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.063698 (rank : 384)
Query Neighborhood Hits	332	Target Neighborhood Hits	281	Shared Neighborhood Hits	31
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SPN90_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.192308 (rank : 169)
Query Neighborhood Hits	332	Target Neighborhood Hits	157	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.165687 (rank : 194)
Query Neighborhood Hits	332	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRMS_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.075065 (rank : 346)
Query Neighborhood Hits	332	Target Neighborhood Hits	946	Shared Neighborhood Hits	79
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.083588 (rank : 319)
Query Neighborhood Hits	332	Target Neighborhood Hits	964	Shared Neighborhood Hits	100
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TEX14_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.057438 (rank : 422)
Query Neighborhood Hits	332	Target Neighborhood Hits	1103	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.060995 (rank : 392)
Query Neighborhood Hits	332	Target Neighborhood Hits	1333	Shared Neighborhood Hits	90
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIAM1_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.172211 (rank : 188)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	34
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.175063 (rank : 183)
Query Neighborhood Hits	332	Target Neighborhood Hits	205	Shared Neighborhood Hits	33
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRIO_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.075403 (rank : 345)
Query Neighborhood Hits	332	Target Neighborhood Hits	1580	Shared Neighborhood Hits	133
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TXK_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.104781 (rank : 277)
Query Neighborhood Hits	332	Target Neighborhood Hits	971	Shared Neighborhood Hits	124
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ZAP70_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.059489 (rank : 407)
Query Neighborhood Hits	332	Target Neighborhood Hits	893	Shared Neighborhood Hits	57
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.059888 (rank : 405)
Query Neighborhood Hits	332	Target Neighborhood Hits	905	Shared Neighborhood Hits	57
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

SH3K1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	332	Target Neighborhood Hits	332	Shared Neighborhood Hits	332
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.989825 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	332	Target Neighborhood Hits	341	Shared Neighborhood Hits	292
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CD2AP_MOUSE
NC score	0.922282 (rank : 3)	θ value	2.31901e-72 (rank : 4)
Query Neighborhood Hits	332	Target Neighborhood Hits	336	Shared Neighborhood Hits	217
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.919308 (rank : 4)	θ value	2.31901e-72 (rank : 3)
Query Neighborhood Hits	332	Target Neighborhood Hits	315	Shared Neighborhood Hits	217
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SRBS1_MOUSE
NC score	0.723064 (rank : 5)	θ value	6.85773e-16 (rank : 9)
Query Neighborhood Hits	332	Target Neighborhood Hits	409	Shared Neighborhood Hits	212
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.722897 (rank : 6)	θ value	1.63604e-09 (rank : 23)
Query Neighborhood Hits	332	Target Neighborhood Hits	270	Shared Neighborhood Hits	203
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.708230 (rank : 7)	θ value	1.06045e-08 (rank : 32)
Query Neighborhood Hits	332	Target Neighborhood Hits	286	Shared Neighborhood Hits	202
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCF2_HUMAN
NC score	0.707221 (rank : 8)	θ value	1.53129e-07 (rank : 47)
Query Neighborhood Hits	332	Target Neighborhood Hits	229	Shared Neighborhood Hits	173
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SRBS1_HUMAN
NC score	0.685266 (rank : 9)	θ value	4.0297e-08 (rank : 42)
Query Neighborhood Hits	332	Target Neighborhood Hits	396	Shared Neighborhood Hits	214
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G3_MOUSE
NC score	0.660278 (rank : 10)	θ value	8.11959e-09 (rank : 27)
Query Neighborhood Hits	332	Target Neighborhood Hits	236	Shared Neighborhood Hits	196
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRC8_HUMAN
NC score	0.658808 (rank : 11)	θ value	1.06045e-08 (rank : 31)
Query Neighborhood Hits	332	Target Neighborhood Hits	269	Shared Neighborhood Hits	186
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

HCLS1_MOUSE
NC score	0.657440 (rank : 12)	θ value	2.36244e-08 (rank : 39)
Query Neighborhood Hits	332	Target Neighborhood Hits	329	Shared Neighborhood Hits	176
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.656580 (rank : 13)	θ value	5.26297e-08 (rank : 43)
Query Neighborhood Hits	332	Target Neighborhood Hits	358	Shared Neighborhood Hits	171
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI2_MOUSE
NC score	0.656472 (rank : 14)	θ value	3.41135e-07 (rank : 50)
Query Neighborhood Hits	332	Target Neighborhood Hits	266	Shared Neighborhood Hits	196
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SRC8_MOUSE
NC score	0.654540 (rank : 15)	θ value	4.76016e-09 (rank : 25)
Query Neighborhood Hits	332	Target Neighborhood Hits	292	Shared Neighborhood Hits	185
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SH3G2_HUMAN
NC score	0.654365 (rank : 16)	θ value	2.98157e-11 (rank : 17)
Query Neighborhood Hits	332	Target Neighborhood Hits	324	Shared Neighborhood Hits	205
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ABI2_HUMAN
NC score	0.652973 (rank : 17)	θ value	3.41135e-07 (rank : 49)
Query Neighborhood Hits	332	Target Neighborhood Hits	350	Shared Neighborhood Hits	202
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SH3G2_MOUSE
NC score	0.652639 (rank : 18)	θ value	1.47974e-10 (rank : 21)
Query Neighborhood Hits	332	Target Neighborhood Hits	319	Shared Neighborhood Hits	207
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
NC score	0.640641 (rank : 19)	θ value	4.0297e-08 (rank : 41)
Query Neighborhood Hits	332	Target Neighborhood Hits	222	Shared Neighborhood Hits	185
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

DNMBP_MOUSE
NC score	0.635348 (rank : 20)	θ value	3.63628e-17 (rank : 7)
Query Neighborhood Hits	332	Target Neighborhood Hits	435	Shared Neighborhood Hits	207
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SH3G1_MOUSE
NC score	0.632850 (rank : 21)	θ value	1.80886e-08 (rank : 37)
Query Neighborhood Hits	332	Target Neighborhood Hits	291	Shared Neighborhood Hits	193
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

DNMBP_HUMAN
NC score	0.632242 (rank : 22)	θ value	8.38298e-14 (rank : 10)
Query Neighborhood Hits	332	Target Neighborhood Hits	413	Shared Neighborhood Hits	202
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG7_MOUSE
NC score	0.631575 (rank : 23)	θ value	3.89403e-11 (rank : 18)
Query Neighborhood Hits	332	Target Neighborhood Hits	396	Shared Neighborhood Hits	223
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

SH3G1_HUMAN
NC score	0.630180 (rank : 24)	θ value	1.80886e-08 (rank : 36)
Query Neighborhood Hits	332	Target Neighborhood Hits	307	Shared Neighborhood Hits	198
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ABI1_MOUSE
NC score	0.628291 (rank : 25)	θ value	7.59969e-07 (rank : 52)
Query Neighborhood Hits	332	Target Neighborhood Hits	246	Shared Neighborhood Hits	178
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ARHG7_HUMAN
NC score	0.624962 (rank : 26)	θ value	6.00763e-12 (rank : 16)
Query Neighborhood Hits	332	Target Neighborhood Hits	347	Shared Neighborhood Hits	214
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

NCF1_MOUSE
NC score	0.623489 (rank : 27)	θ value	2.36244e-08 (rank : 40)
Query Neighborhood Hits	332	Target Neighborhood Hits	198	Shared Neighborhood Hits	169
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

GRB2_HUMAN
NC score	0.622772 (rank : 28)	θ value	1.58096e-12 (rank : 12)
Query Neighborhood Hits	332	Target Neighborhood Hits	310	Shared Neighborhood Hits	193
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.622693 (rank : 29)	θ value	1.58096e-12 (rank : 13)
Query Neighborhood Hits	332	Target Neighborhood Hits	312	Shared Neighborhood Hits	193
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCK1_HUMAN
NC score	0.620185 (rank : 30)	θ value	2.69671e-12 (rank : 14)
Query Neighborhood Hits	332	Target Neighborhood Hits	312	Shared Neighborhood Hits	192
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCF1_HUMAN
NC score	0.619308 (rank : 31)	θ value	8.97725e-08 (rank : 45)
Query Neighborhood Hits	332	Target Neighborhood Hits	198	Shared Neighborhood Hits	158
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ARHG6_MOUSE
NC score	0.618348 (rank : 32)	θ value	1.47974e-10 (rank : 20)
Query Neighborhood Hits	332	Target Neighborhood Hits	394	Shared Neighborhood Hits	212
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

NCK2_HUMAN
NC score	0.615779 (rank : 33)	θ value	3.52202e-12 (rank : 15)
Query Neighborhood Hits	332	Target Neighborhood Hits	310	Shared Neighborhood Hits	196
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG6_HUMAN
NC score	0.611943 (rank : 34)	θ value	6.64225e-11 (rank : 19)
Query Neighborhood Hits	332	Target Neighborhood Hits	376	Shared Neighborhood Hits	213
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ABI1_HUMAN
NC score	0.610610 (rank : 35)	θ value	2.21117e-06 (rank : 64)
Query Neighborhood Hits	332	Target Neighborhood Hits	257	Shared Neighborhood Hits	178
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

NCF4_MOUSE
NC score	0.605832 (rank : 36)	θ value	9.29e-05 (rank : 89)
Query Neighborhood Hits	332	Target Neighborhood Hits	177	Shared Neighborhood Hits	145
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_HUMAN
NC score	0.600699 (rank : 37)	θ value	5.81887e-07 (rank : 51)
Query Neighborhood Hits	332	Target Neighborhood Hits	276	Shared Neighborhood Hits	186
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM2_MOUSE
NC score	0.599526 (rank : 38)	θ value	1.80886e-08 (rank : 38)
Query Neighborhood Hits	332	Target Neighborhood Hits	285	Shared Neighborhood Hits	198
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM1_HUMAN
NC score	0.599034 (rank : 39)	θ value	1.29631e-06 (rank : 61)
Query Neighborhood Hits	332	Target Neighborhood Hits	271	Shared Neighborhood Hits	196
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.598732 (rank : 40)	θ value	1.29631e-06 (rank : 62)
Query Neighborhood Hits	332	Target Neighborhood Hits	273	Shared Neighborhood Hits	194
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PPIP1_HUMAN
NC score	0.595138 (rank : 41)	θ value	2.61198e-07 (rank : 48)
Query Neighborhood Hits	332	Target Neighborhood Hits	389	Shared Neighborhood Hits	208
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
NC score	0.594325 (rank : 42)	θ value	1.69304e-06 (rank : 63)
Query Neighborhood Hits	332	Target Neighborhood Hits	377	Shared Neighborhood Hits	216
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

GRAP_MOUSE
NC score	0.590960 (rank : 43)	θ value	1.06045e-08 (rank : 28)
Query Neighborhood Hits	332	Target Neighborhood Hits	309	Shared Neighborhood Hits	203
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCF4_HUMAN
NC score	0.589420 (rank : 44)	θ value	5.44631e-05 (rank : 85)
Query Neighborhood Hits	332	Target Neighborhood Hits	161	Shared Neighborhood Hits	128
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_MOUSE
NC score	0.586638 (rank : 45)	θ value	2.21117e-06 (rank : 65)
Query Neighborhood Hits	332	Target Neighborhood Hits	268	Shared Neighborhood Hits	184
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP2_MOUSE
NC score	0.576281 (rank : 46)	θ value	0.000121331 (rank : 90)
Query Neighborhood Hits	332	Target Neighborhood Hits	297	Shared Neighborhood Hits	194
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
NC score	0.575116 (rank : 47)	θ value	9.92553e-07 (rank : 59)
Query Neighborhood Hits	332	Target Neighborhood Hits	307	Shared Neighborhood Hits	201
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

STAM2_HUMAN
NC score	0.574980 (rank : 48)	θ value	6.43352e-06 (rank : 70)
Query Neighborhood Hits	332	Target Neighborhood Hits	288	Shared Neighborhood Hits	195
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

GRAP2_HUMAN
NC score	0.570205 (rank : 49)	θ value	5.44631e-05 (rank : 84)
Query Neighborhood Hits	332	Target Neighborhood Hits	304	Shared Neighborhood Hits	191
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRKL_HUMAN
NC score	0.554988 (rank : 50)	θ value	1.43324e-05 (rank : 78)
Query Neighborhood Hits	332	Target Neighborhood Hits	313	Shared Neighborhood Hits	191
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.546161 (rank : 51)	θ value	1.09739e-05 (rank : 74)
Query Neighborhood Hits	332	Target Neighborhood Hits	307	Shared Neighborhood Hits	188
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
NC score	0.546067 (rank : 52)	θ value	5.44631e-05 (rank : 82)
Query Neighborhood Hits	332	Target Neighborhood Hits	314	Shared Neighborhood Hits	193
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PACN2_HUMAN
NC score	0.542174 (rank : 53)	θ value	0.000158464 (rank : 94)
Query Neighborhood Hits	332	Target Neighborhood Hits	339	Shared Neighborhood Hits	198
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ABI3_MOUSE
NC score	0.541765 (rank : 54)	θ value	0.000602161 (rank : 107)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	152
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_HUMAN
NC score	0.540764 (rank : 55)	θ value	0.00102713 (rank : 116)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	151
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PACN2_MOUSE
NC score	0.540537 (rank : 56)	θ value	6.43352e-06 (rank : 68)
Query Neighborhood Hits	332	Target Neighborhood Hits	382	Shared Neighborhood Hits	199
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CRK_HUMAN
NC score	0.531038 (rank : 57)	θ value	0.000602161 (rank : 108)
Query Neighborhood Hits	332	Target Neighborhood Hits	308	Shared Neighborhood Hits	195
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PACN1_HUMAN
NC score	0.528092 (rank : 58)	θ value	0.00020696 (rank : 97)
Query Neighborhood Hits	332	Target Neighborhood Hits	320	Shared Neighborhood Hits	188
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.527008 (rank : 59)	θ value	0.000786445 (rank : 115)
Query Neighborhood Hits	332	Target Neighborhood Hits	283	Shared Neighborhood Hits	185
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ITSN2_HUMAN
NC score	0.519151 (rank : 60)	θ value	1.2105e-12 (rank : 11)
Query Neighborhood Hits	332	Target Neighborhood Hits	1173	Shared Neighborhood Hits	256
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

STAC3_MOUSE
NC score	0.518305 (rank : 61)	θ value	0.00102713 (rank : 123)
Query Neighborhood Hits	332	Target Neighborhood Hits	232	Shared Neighborhood Hits	149
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VAV_MOUSE
NC score	0.517500 (rank : 62)	θ value	5.26297e-08 (rank : 44)
Query Neighborhood Hits	332	Target Neighborhood Hits	430	Shared Neighborhood Hits	199
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.515529 (rank : 63)	θ value	1.17247e-07 (rank : 46)
Query Neighborhood Hits	332	Target Neighborhood Hits	452	Shared Neighborhood Hits	197
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

STAC3_HUMAN
NC score	0.515503 (rank : 64)	θ value	0.00102713 (rank : 122)
Query Neighborhood Hits	332	Target Neighborhood Hits	228	Shared Neighborhood Hits	148
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

DBNL_HUMAN
NC score	0.514019 (rank : 65)	θ value	0.000602161 (rank : 109)
Query Neighborhood Hits	332	Target Neighborhood Hits	244	Shared Neighborhood Hits	148
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

OSTF1_HUMAN
NC score	0.508216 (rank : 66)	θ value	1.09739e-05 (rank : 75)
Query Neighborhood Hits	332	Target Neighborhood Hits	466	Shared Neighborhood Hits	200
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

DBNL_MOUSE
NC score	0.507713 (rank : 67)	θ value	0.000602161 (rank : 110)
Query Neighborhood Hits	332	Target Neighborhood Hits	306	Shared Neighborhood Hits	156
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ITSN2_MOUSE
NC score	0.501809 (rank : 68)	θ value	6.20254e-17 (rank : 8)
Query Neighborhood Hits	332	Target Neighborhood Hits	1371	Shared Neighborhood Hits	261
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_MOUSE
NC score	0.501589 (rank : 69)	θ value	2.7842e-17 (rank : 6)
Query Neighborhood Hits	332	Target Neighborhood Hits	1669	Shared Neighborhood Hits	282
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.501450 (rank : 70)	θ value	1.47631e-18 (rank : 5)
Query Neighborhood Hits	332	Target Neighborhood Hits	1757	Shared Neighborhood Hits	280
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PACN3_MOUSE
NC score	0.500043 (rank : 71)	θ value	0.00102713 (rank : 120)
Query Neighborhood Hits	332	Target Neighborhood Hits	380	Shared Neighborhood Hits	198
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.499360 (rank : 72)	θ value	0.00102713 (rank : 119)
Query Neighborhood Hits	332	Target Neighborhood Hits	385	Shared Neighborhood Hits	197
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

OSTF1_MOUSE
NC score	0.497978 (rank : 73)	θ value	8.40245e-06 (rank : 71)
Query Neighborhood Hits	332	Target Neighborhood Hits	467	Shared Neighborhood Hits	200
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

LASP1_HUMAN
NC score	0.490890 (rank : 74)	θ value	0.00175202 (rank : 127)
Query Neighborhood Hits	332	Target Neighborhood Hits	293	Shared Neighborhood Hits	162
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.487901 (rank : 75)	θ value	0.00175202 (rank : 128)
Query Neighborhood Hits	332	Target Neighborhood Hits	297	Shared Neighborhood Hits	162
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CT032_HUMAN
NC score	0.483704 (rank : 76)	θ value	0.0113563 (rank : 146)
Query Neighborhood Hits	332	Target Neighborhood Hits	235	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

BCAR1_MOUSE
NC score	0.476374 (rank : 77)	θ value	9.92553e-07 (rank : 57)
Query Neighborhood Hits	332	Target Neighborhood Hits	438	Shared Neighborhood Hits	174
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

VAV2_HUMAN
NC score	0.475836 (rank : 78)	θ value	1.09739e-05 (rank : 76)
Query Neighborhood Hits	332	Target Neighborhood Hits	453	Shared Neighborhood Hits	188
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.475167 (rank : 79)	θ value	1.09739e-05 (rank : 77)
Query Neighborhood Hits	332	Target Neighborhood Hits	456	Shared Neighborhood Hits	190
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

BCAR1_HUMAN
NC score	0.464245 (rank : 80)	θ value	1.29631e-06 (rank : 60)
Query Neighborhood Hits	332	Target Neighborhood Hits	554	Shared Neighborhood Hits	177
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NEBL_HUMAN
NC score	0.462163 (rank : 81)	θ value	0.000602161 (rank : 111)
Query Neighborhood Hits	332	Target Neighborhood Hits	457	Shared Neighborhood Hits	195
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NPHP1_MOUSE
NC score	0.461593 (rank : 82)	θ value	0.0736092 (rank : 178)
Query Neighborhood Hits	332	Target Neighborhood Hits	267	Shared Neighborhood Hits	181
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

RIMB2_MOUSE
NC score	0.454335 (rank : 83)	θ value	1.80886e-08 (rank : 35)
Query Neighborhood Hits	332	Target Neighborhood Hits	246	Shared Neighborhood Hits	119
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PLCG1_MOUSE
NC score	0.451739 (rank : 84)	θ value	2.13673e-09 (rank : 24)
Query Neighborhood Hits	332	Target Neighborhood Hits	314	Shared Neighborhood Hits	166
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV3_HUMAN
NC score	0.448893 (rank : 85)	θ value	0.000158464 (rank : 95)
Query Neighborhood Hits	332	Target Neighborhood Hits	398	Shared Neighborhood Hits	186
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

RIMB2_HUMAN
NC score	0.445146 (rank : 86)	θ value	6.43352e-06 (rank : 69)
Query Neighborhood Hits	332	Target Neighborhood Hits	263	Shared Neighborhood Hits	130
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

EFS_MOUSE
NC score	0.444925 (rank : 87)	θ value	0.000270298 (rank : 98)
Query Neighborhood Hits	332	Target Neighborhood Hits	389	Shared Neighborhood Hits	155
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

VAV3_MOUSE
NC score	0.442421 (rank : 88)	θ value	0.000270298 (rank : 102)
Query Neighborhood Hits	332	Target Neighborhood Hits	404	Shared Neighborhood Hits	184
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

CASL_MOUSE
NC score	0.438198 (rank : 89)	θ value	0.000461057 (rank : 106)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	149
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

PLCG1_HUMAN
NC score	0.436101 (rank : 90)	θ value	1.38499e-08 (rank : 34)
Query Neighborhood Hits	332	Target Neighborhood Hits	293	Shared Neighborhood Hits	158
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

AHI1_HUMAN
NC score	0.435306 (rank : 91)	θ value	9.29e-05 (rank : 88)
Query Neighborhood Hits	332	Target Neighborhood Hits	537	Shared Neighborhood Hits	197
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CASL_HUMAN
NC score	0.435047 (rank : 92)	θ value	0.000461057 (rank : 105)
Query Neighborhood Hits	332	Target Neighborhood Hits	259	Shared Neighborhood Hits	152
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

ARHG4_HUMAN
NC score	0.434771 (rank : 93)	θ value	0.000461057 (rank : 104)
Query Neighborhood Hits	332	Target Neighborhood Hits	242	Shared Neighborhood Hits	160
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

AHI1_MOUSE
NC score	0.430018 (rank : 94)	θ value	0.000461057 (rank : 103)
Query Neighborhood Hits	332	Target Neighborhood Hits	496	Shared Neighborhood Hits	195
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

PLCG2_HUMAN
NC score	0.426132 (rank : 95)	θ value	7.59969e-07 (rank : 56)
Query Neighborhood Hits	332	Target Neighborhood Hits	280	Shared Neighborhood Hits	154
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

EFS_HUMAN
NC score	0.421299 (rank : 96)	θ value	0.0431538 (rank : 166)
Query Neighborhood Hits	332	Target Neighborhood Hits	348	Shared Neighborhood Hits	153
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

NPHP1_HUMAN
NC score	0.421060 (rank : 97)	θ value	0.0330416 (rank : 163)
Query Neighborhood Hits	332	Target Neighborhood Hits	288	Shared Neighborhood Hits	163
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ARHG9_HUMAN
NC score	0.420263 (rank : 98)	θ value	0.00102713 (rank : 117)
Query Neighborhood Hits	332	Target Neighborhood Hits	235	Shared Neighborhood Hits	156
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.419540 (rank : 99)	θ value	0.000786445 (rank : 113)
Query Neighborhood Hits	332	Target Neighborhood Hits	234	Shared Neighborhood Hits	155
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

NOXO1_MOUSE
NC score	0.402040 (rank : 100)	θ value	0.0431538 (rank : 168)
Query Neighborhood Hits	332	Target Neighborhood Hits	114	Shared Neighborhood Hits	103
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NEBU_HUMAN
NC score	0.389161 (rank : 101)	θ value	0.00298849 (rank : 135)
Query Neighborhood Hits	332	Target Neighborhood Hits	420	Shared Neighborhood Hits	177
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SNX18_MOUSE
NC score	0.382408 (rank : 102)	θ value	0.365318 (rank : 201)
Query Neighborhood Hits	332	Target Neighborhood Hits	198	Shared Neighborhood Hits	130
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_HUMAN
NC score	0.374684 (rank : 103)	θ value	0.365318 (rank : 200)
Query Neighborhood Hits	332	Target Neighborhood Hits	207	Shared Neighborhood Hits	131
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

RHG04_HUMAN
NC score	0.363137 (rank : 104)	θ value	0.000602161 (rank : 112)
Query Neighborhood Hits	332	Target Neighborhood Hits	307	Shared Neighborhood Hits	164
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ARHG4_MOUSE
NC score	0.361271 (rank : 105)	θ value	0.00298849 (rank : 133)
Query Neighborhood Hits	332	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PEX13_MOUSE
NC score	0.360287 (rank : 106)	θ value	1.06291 (rank : 229)
Query Neighborhood Hits	332	Target Neighborhood Hits	126	Shared Neighborhood Hits	114
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

IASPP_HUMAN
NC score	0.347796 (rank : 107)	θ value	0.00102713 (rank : 118)
Query Neighborhood Hits	332	Target Neighborhood Hits	688	Shared Neighborhood Hits	173
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PEX13_HUMAN
NC score	0.338324 (rank : 108)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	332	Target Neighborhood Hits	128	Shared Neighborhood Hits	109
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ASPP1_HUMAN
NC score	0.337868 (rank : 109)	θ value	1.09739e-05 (rank : 72)
Query Neighborhood Hits	332	Target Neighborhood Hits	956	Shared Neighborhood Hits	208
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
NC score	0.332719 (rank : 110)	θ value	1.09739e-05 (rank : 73)
Query Neighborhood Hits	332	Target Neighborhood Hits	1244	Shared Neighborhood Hits	211
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SRGP2_MOUSE
NC score	0.332189 (rank : 111)	θ value	4.1701e-05 (rank : 81)
Query Neighborhood Hits	332	Target Neighborhood Hits	324	Shared Neighborhood Hits	160
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.329122 (rank : 112)	θ value	2.44474e-05 (rank : 79)
Query Neighborhood Hits	332	Target Neighborhood Hits	331	Shared Neighborhood Hits	157
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

DDEF1_MOUSE
NC score	0.324345 (rank : 113)	θ value	9.92553e-07 (rank : 58)
Query Neighborhood Hits	332	Target Neighborhood Hits	592	Shared Neighborhood Hits	166
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

RHG26_HUMAN
NC score	0.324209 (rank : 114)	θ value	4.1701e-05 (rank : 80)
Query Neighborhood Hits	332	Target Neighborhood Hits	281	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SNX9_HUMAN
NC score	0.322164 (rank : 115)	θ value	4.92598e-06 (rank : 67)
Query Neighborhood Hits	332	Target Neighborhood Hits	148	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

IASPP_MOUSE
NC score	0.319889 (rank : 116)	θ value	0.000786445 (rank : 114)
Query Neighborhood Hits	332	Target Neighborhood Hits	1024	Shared Neighborhood Hits	179
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SRGP1_HUMAN
NC score	0.311762 (rank : 117)	θ value	0.000121331 (rank : 93)
Query Neighborhood Hits	332	Target Neighborhood Hits	390	Shared Neighborhood Hits	159
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.311727 (rank : 118)	θ value	0.00020696 (rank : 96)
Query Neighborhood Hits	332	Target Neighborhood Hits	432	Shared Neighborhood Hits	162
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ES8L3_MOUSE
NC score	0.304299 (rank : 119)	θ value	0.0961366 (rank : 182)
Query Neighborhood Hits	332	Target Neighborhood Hits	168	Shared Neighborhood Hits	135
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

MYO1F_HUMAN
NC score	0.304185 (rank : 120)	θ value	1.38499e-08 (rank : 33)
Query Neighborhood Hits	332	Target Neighborhood Hits	275	Shared Neighborhood Hits	203
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.302324 (rank : 121)	θ value	1.06045e-08 (rank : 30)
Query Neighborhood Hits	332	Target Neighborhood Hits	262	Shared Neighborhood Hits	199
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NOXO1_HUMAN
NC score	0.302045 (rank : 122)	θ value	0.62314 (rank : 215)
Query Neighborhood Hits	332	Target Neighborhood Hits	100	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SHLB1_MOUSE
NC score	0.301126 (rank : 123)	θ value	0.0431538 (rank : 171)
Query Neighborhood Hits	332	Target Neighborhood Hits	101	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

MYO1E_HUMAN
NC score	0.299700 (rank : 124)	θ value	6.21693e-09 (rank : 26)
Query Neighborhood Hits	332	Target Neighborhood Hits	293	Shared Neighborhood Hits	200
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SHLB1_HUMAN
NC score	0.296554 (rank : 125)	θ value	0.0431538 (rank : 170)
Query Neighborhood Hits	332	Target Neighborhood Hits	96	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

DDEF2_MOUSE
NC score	0.296393 (rank : 126)	θ value	7.1131e-05 (rank : 87)
Query Neighborhood Hits	332	Target Neighborhood Hits	625	Shared Neighborhood Hits	171
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ASPP2_HUMAN
NC score	0.292641 (rank : 127)	θ value	7.59969e-07 (rank : 53)
Query Neighborhood Hits	332	Target Neighborhood Hits	1156	Shared Neighborhood Hits	196
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

DDEF2_HUMAN
NC score	0.290193 (rank : 128)	θ value	5.44631e-05 (rank : 83)
Query Neighborhood Hits	332	Target Neighborhood Hits	599	Shared Neighborhood Hits	169
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SNX9_MOUSE
NC score	0.288244 (rank : 129)	θ value	0.000121331 (rank : 92)
Query Neighborhood Hits	332	Target Neighborhood Hits	141	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

ANM2_HUMAN
NC score	0.287091 (rank : 130)	θ value	1.06291 (rank : 226)
Query Neighborhood Hits	332	Target Neighborhood Hits	175	Shared Neighborhood Hits	144
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG5_HUMAN
NC score	0.286337 (rank : 131)	θ value	0.0193708 (rank : 149)
Query Neighborhood Hits	332	Target Neighborhood Hits	172	Shared Neighborhood Hits	102
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

STS2_HUMAN
NC score	0.284128 (rank : 132)	θ value	0.0736092 (rank : 179)
Query Neighborhood Hits	332	Target Neighborhood Hits	108	Shared Neighborhood Hits	92
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

RUSC1_HUMAN
NC score	0.283912 (rank : 133)	θ value	6.88961 (rank : 315)
Query Neighborhood Hits	332	Target Neighborhood Hits	226	Shared Neighborhood Hits	137
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SHAN2_MOUSE
NC score	0.280473 (rank : 134)	θ value	0.00175202 (rank : 129)
Query Neighborhood Hits	332	Target Neighborhood Hits	446	Shared Neighborhood Hits	130
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ANM2_MOUSE
NC score	0.273442 (rank : 135)	θ value	2.36792 (rank : 250)
Query Neighborhood Hits	332	Target Neighborhood Hits	175	Shared Neighborhood Hits	138
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SLY_MOUSE
NC score	0.272293 (rank : 136)	θ value	0.000270298 (rank : 101)
Query Neighborhood Hits	332	Target Neighborhood Hits	108	Shared Neighborhood Hits	67
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

ES8L3_HUMAN
NC score	0.271727 (rank : 137)	θ value	0.0961366 (rank : 181)
Query Neighborhood Hits	332	Target Neighborhood Hits	206	Shared Neighborhood Hits	119
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NGEF_MOUSE
NC score	0.271440 (rank : 138)	θ value	0.0252991 (rank : 159)
Query Neighborhood Hits	332	Target Neighborhood Hits	228	Shared Neighborhood Hits	95
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SPTA2_HUMAN
NC score	0.269221 (rank : 139)	θ value	5.44631e-05 (rank : 86)
Query Neighborhood Hits	332	Target Neighborhood Hits	888	Shared Neighborhood Hits	212
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

TCGAP_MOUSE
NC score	0.266947 (rank : 140)	θ value	0.0193708 (rank : 153)
Query Neighborhood Hits	332	Target Neighborhood Hits	409	Shared Neighborhood Hits	144
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

NGEF_HUMAN
NC score	0.266479 (rank : 141)	θ value	0.0431538 (rank : 167)
Query Neighborhood Hits	332	Target Neighborhood Hits	166	Shared Neighborhood Hits	87
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RIMB1_HUMAN
NC score	0.264387 (rank : 142)	θ value	0.00102713 (rank : 121)
Query Neighborhood Hits	332	Target Neighborhood Hits	1479	Shared Neighborhood Hits	198
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
NC score	0.257922 (rank : 143)	θ value	0.000121331 (rank : 91)
Query Neighborhood Hits	332	Target Neighborhood Hits	1376	Shared Neighborhood Hits	214
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

STS1_HUMAN
NC score	0.255720 (rank : 144)	θ value	0.00175202 (rank : 130)
Query Neighborhood Hits	332	Target Neighborhood Hits	106	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.255446 (rank : 145)	θ value	0.00228821 (rank : 132)
Query Neighborhood Hits	332	Target Neighborhood Hits	104	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SLY_HUMAN
NC score	0.254551 (rank : 146)	θ value	0.000270298 (rank : 100)
Query Neighborhood Hits	332	Target Neighborhood Hits	81	Shared Neighborhood Hits	59
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

AMPH_HUMAN
NC score	0.252257 (rank : 147)	θ value	0.00509761 (rank : 143)
Query Neighborhood Hits	332	Target Neighborhood Hits	455	Shared Neighborhood Hits	106
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
NC score	0.249262 (rank : 148)	θ value	0.0193708 (rank : 148)
Query Neighborhood Hits	332	Target Neighborhood Hits	291	Shared Neighborhood Hits	91
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

RUSC1_MOUSE
NC score	0.248735 (rank : 149)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	332	Target Neighborhood Hits	206	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ES8L2_HUMAN
NC score	0.242015 (rank : 150)	θ value	0.62314 (rank : 211)
Query Neighborhood Hits	332	Target Neighborhood Hits	193	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ARHGG_MOUSE
NC score	0.240218 (rank : 151)	θ value	0.0330416 (rank : 160)
Query Neighborhood Hits	332	Target Neighborhood Hits	152	Shared Neighborhood Hits	72
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SPTA1_MOUSE
NC score	0.238970 (rank : 152)	θ value	0.0193708 (rank : 152)
Query Neighborhood Hits	332	Target Neighborhood Hits	675	Shared Neighborhood Hits	181
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TCGAP_HUMAN
NC score	0.237182 (rank : 153)	θ value	0.0113563 (rank : 147)
Query Neighborhood Hits	332	Target Neighborhood Hits	872	Shared Neighborhood Hits	144
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BIN1_HUMAN
NC score	0.237048 (rank : 154)	θ value	0.00509761 (rank : 144)
Query Neighborhood Hits	332	Target Neighborhood Hits	335	Shared Neighborhood Hits	91
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SPTA1_HUMAN
NC score	0.236941 (rank : 155)	θ value	0.00390308 (rank : 142)
Query Neighborhood Hits	332	Target Neighborhood Hits	748	Shared Neighborhood Hits	190
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ES8L2_MOUSE
NC score	0.236207 (rank : 156)	θ value	0.47712 (rank : 206)
Query Neighborhood Hits	332	Target Neighborhood Hits	169	Shared Neighborhood Hits	119
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

BIN1_MOUSE
NC score	0.233904 (rank : 157)	θ value	0.0252991 (rank : 156)
Query Neighborhood Hits	332	Target Neighborhood Hits	283	Shared Neighborhood Hits	86
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

SHLB2_HUMAN
NC score	0.233639 (rank : 158)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	332	Target Neighborhood Hits	86	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
NC score	0.233487 (rank : 159)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	332	Target Neighborhood Hits	88	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHAN1_HUMAN
NC score	0.229133 (rank : 160)	θ value	2.88788e-06 (rank : 66)
Query Neighborhood Hits	332	Target Neighborhood Hits	1041	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EPS8_MOUSE
NC score	0.228083 (rank : 161)	θ value	0.365318 (rank : 196)
Query Neighborhood Hits	332	Target Neighborhood Hits	157	Shared Neighborhood Hits	118
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_HUMAN
NC score	0.227598 (rank : 162)	θ value	0.813845 (rank : 219)
Query Neighborhood Hits	332	Target Neighborhood Hits	151	Shared Neighborhood Hits	103
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

BI2L1_HUMAN
NC score	0.217428 (rank : 163)	θ value	0.0330416 (rank : 161)
Query Neighborhood Hits	332	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ARHGG_HUMAN
NC score	0.214603 (rank : 164)	θ value	0.0736092 (rank : 177)
Query Neighborhood Hits	332	Target Neighborhood Hits	129	Shared Neighborhood Hits	55
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

P85A_MOUSE
NC score	0.200929 (rank : 165)	θ value	0.163984 (rank : 190)
Query Neighborhood Hits	332	Target Neighborhood Hits	435	Shared Neighborhood Hits	123
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BAIP2_MOUSE
NC score	0.199552 (rank : 166)	θ value	0.00390308 (rank : 138)
Query Neighborhood Hits	332	Target Neighborhood Hits	185	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAIP2_HUMAN
NC score	0.197911 (rank : 167)	θ value	0.00390308 (rank : 137)
Query Neighborhood Hits	332	Target Neighborhood Hits	192	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

ES8L1_HUMAN
NC score	0.193118 (rank : 168)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	332	Target Neighborhood Hits	162	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SPN90_HUMAN
NC score	0.192308 (rank : 169)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	332	Target Neighborhood Hits	157	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ES8L1_MOUSE
NC score	0.191599 (rank : 170)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	332	Target Neighborhood Hits	143	Shared Neighborhood Hits	93
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

P85A_HUMAN
NC score	0.190612 (rank : 171)	θ value	1.38821 (rank : 238)
Query Neighborhood Hits	332	Target Neighborhood Hits	479	Shared Neighborhood Hits	128
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

EM55_HUMAN
NC score	0.188540 (rank : 172)	θ value	0.0961366 (rank : 180)
Query Neighborhood Hits	332	Target Neighborhood Hits	228	Shared Neighborhood Hits	97
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

M3KL4_HUMAN
NC score	0.188122 (rank : 173)	θ value	7.59969e-07 (rank : 55)
Query Neighborhood Hits	332	Target Neighborhood Hits	1087	Shared Neighborhood Hits	186
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

EM55_MOUSE
NC score	0.187935 (rank : 174)	θ value	0.0330416 (rank : 162)
Query Neighborhood Hits	332	Target Neighborhood Hits	221	Shared Neighborhood Hits	93
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

PKHG1_HUMAN
NC score	0.187647 (rank : 175)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	332	Target Neighborhood Hits	174	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

DOCK1_HUMAN
NC score	0.183618 (rank : 176)	θ value	0.0193708 (rank : 151)
Query Neighborhood Hits	332	Target Neighborhood Hits	191	Shared Neighborhood Hits	119
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SASH1_HUMAN
NC score	0.183192 (rank : 177)	θ value	0.0431538 (rank : 169)
Query Neighborhood Hits	332	Target Neighborhood Hits	292	Shared Neighborhood Hits	71
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

M3K11_HUMAN
NC score	0.178204 (rank : 178)	θ value	7.59969e-07 (rank : 54)
Query Neighborhood Hits	332	Target Neighborhood Hits	1136	Shared Neighborhood Hits	191
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PREX1_HUMAN
NC score	0.178122 (rank : 179)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	332	Target Neighborhood Hits	177	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG3_HUMAN
NC score	0.176767 (rank : 180)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	332	Target Neighborhood Hits	82	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.176365 (rank : 181)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	332	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

M3K9_HUMAN
NC score	0.175804 (rank : 182)	θ value	1.63604e-09 (rank : 22)
Query Neighborhood Hits	332	Target Neighborhood Hits	1123	Shared Neighborhood Hits	187
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

TIAM1_MOUSE
NC score	0.175063 (rank : 183)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	332	Target Neighborhood Hits	205	Shared Neighborhood Hits	33
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SASH1_MOUSE
NC score	0.174349 (rank : 184)	θ value	0.163984 (rank : 191)
Query Neighborhood Hits	332	Target Neighborhood Hits	263	Shared Neighborhood Hits	67
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ARHG8_MOUSE
NC score	0.174080 (rank : 185)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	332	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

MCF2L_MOUSE
NC score	0.173859 (rank : 186)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	332	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FGR_HUMAN
NC score	0.172833 (rank : 187)	θ value	0.000270298 (rank : 99)
Query Neighborhood Hits	332	Target Neighborhood Hits	1067	Shared Neighborhood Hits	177
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TIAM1_HUMAN
NC score	0.172211 (rank : 188)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	34
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FYN_MOUSE
NC score	0.171746 (rank : 189)	θ value	0.00390308 (rank : 140)
Query Neighborhood Hits	332	Target Neighborhood Hits	1073	Shared Neighborhood Hits	183
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SAMN1_HUMAN
NC score	0.170991 (rank : 190)	θ value	1.06291 (rank : 234)
Query Neighborhood Hits	332	Target Neighborhood Hits	74	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

MPP6_HUMAN
NC score	0.169683 (rank : 191)	θ value	0.0563607 (rank : 176)
Query Neighborhood Hits	332	Target Neighborhood Hits	180	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

FYN_HUMAN
NC score	0.168730 (rank : 192)	θ value	0.00390308 (rank : 139)
Query Neighborhood Hits	332	Target Neighborhood Hits	1078	Shared Neighborhood Hits	183
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

YES_MOUSE
NC score	0.166664 (rank : 193)	θ value	0.0193708 (rank : 155)
Query Neighborhood Hits	332	Target Neighborhood Hits	1052	Shared Neighborhood Hits	180
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SPN90_MOUSE
NC score	0.165687 (rank : 194)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	332	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

YES_HUMAN
NC score	0.164804 (rank : 195)	θ value	0.0193708 (rank : 154)
Query Neighborhood Hits	332	Target Neighborhood Hits	1059	Shared Neighborhood Hits	180
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CIP4_HUMAN
NC score	0.164500 (rank : 196)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	332	Target Neighborhood Hits	374	Shared Neighborhood Hits	103
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

MPP6_MOUSE
NC score	0.164462 (rank : 197)	θ value	0.0961366 (rank : 183)
Query Neighborhood Hits	332	Target Neighborhood Hits	187	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

FGR_MOUSE
NC score	0.163886 (rank : 198)	θ value	0.00175202 (rank : 126)
Query Neighborhood Hits	332	Target Neighborhood Hits	1069	Shared Neighborhood Hits	178
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLAP2_HUMAN
NC score	0.163729 (rank : 199)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	332	Target Neighborhood Hits	139	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SAMN1_MOUSE
NC score	0.163570 (rank : 200)	θ value	1.38821 (rank : 242)
Query Neighborhood Hits	332	Target Neighborhood Hits	69	Shared Neighborhood Hits	48
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SLAP2_MOUSE
NC score	0.161075 (rank : 201)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	332	Target Neighborhood Hits	136	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ARHG8_HUMAN
NC score	0.160976 (rank : 202)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	332	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SRC_HUMAN
NC score	0.159971 (rank : 203)	θ value	0.62314 (rank : 217)
Query Neighborhood Hits	332	Target Neighborhood Hits	1058	Shared Neighborhood Hits	182
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

BI2L1_MOUSE
NC score	0.158010 (rank : 204)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	332	Target Neighborhood Hits	197	Shared Neighborhood Hits	65
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

M3K10_HUMAN
NC score	0.156798 (rank : 205)	θ value	1.06045e-08 (rank : 29)
Query Neighborhood Hits	332	Target Neighborhood Hits	1071	Shared Neighborhood Hits	167
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

FUT8_HUMAN
NC score	0.156665 (rank : 206)	θ value	0.0252991 (rank : 157)
Query Neighborhood Hits	332	Target Neighborhood Hits	67	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

P85B_HUMAN
NC score	0.155502 (rank : 207)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	332	Target Neighborhood Hits	543	Shared Neighborhood Hits	116
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

FUT8_MOUSE
NC score	0.153271 (rank : 208)	θ value	0.0252991 (rank : 158)
Query Neighborhood Hits	332	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

BTK_HUMAN
NC score	0.151487 (rank : 209)	θ value	0.00228821 (rank : 131)
Query Neighborhood Hits	332	Target Neighborhood Hits	1026	Shared Neighborhood Hits	173
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

P85B_MOUSE
NC score	0.147931 (rank : 210)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	332	Target Neighborhood Hits	519	Shared Neighborhood Hits	113
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SLAP1_HUMAN
NC score	0.145636 (rank : 211)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	332	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

BTK_MOUSE
NC score	0.145475 (rank : 212)	θ value	0.00298849 (rank : 134)
Query Neighborhood Hits	332	Target Neighborhood Hits	1017	Shared Neighborhood Hits	163
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SLAP1_MOUSE
NC score	0.144710 (rank : 213)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	332	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

ARHGA_MOUSE
NC score	0.144297 (rank : 214)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	332	Target Neighborhood Hits	125	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MCF2_HUMAN
NC score	0.143878 (rank : 215)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	332	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

RASA1_HUMAN
NC score	0.142704 (rank : 216)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	332	Target Neighborhood Hits	258	Shared Neighborhood Hits	71
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

ARHGF_HUMAN
NC score	0.140361 (rank : 217)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	332	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ECT2_MOUSE
NC score	0.140103 (rank : 218)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	332	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_HUMAN
NC score	0.139923 (rank : 219)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	332	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

HCK_MOUSE
NC score	0.138245 (rank : 220)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	332	Target Neighborhood Hits	1029	Shared Neighborhood Hits	165
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCK_HUMAN
NC score	0.137780 (rank : 221)	θ value	6.88961 (rank : 301)
Query Neighborhood Hits	332	Target Neighborhood Hits	1035	Shared Neighborhood Hits	164
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SRC_MOUSE
NC score	0.135914 (rank : 222)	θ value	1.81305 (rank : 246)
Query Neighborhood Hits	332	Target Neighborhood Hits	1033	Shared Neighborhood Hits	159
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ECT2_HUMAN
NC score	0.135744 (rank : 223)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	332	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

MPP5_HUMAN
NC score	0.135193 (rank : 224)	θ value	0.279714 (rank : 194)
Query Neighborhood Hits	332	Target Neighborhood Hits	231	Shared Neighborhood Hits	72
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.134522 (rank : 225)	θ value	0.279714 (rank : 195)
Query Neighborhood Hits	332	Target Neighborhood Hits	226	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

JIP2_MOUSE
NC score	0.134219 (rank : 226)	θ value	0.62314 (rank : 213)
Query Neighborhood Hits	332	Target Neighborhood Hits	144	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

FRK_HUMAN
NC score	0.134014 (rank : 227)	θ value	0.163984 (rank : 189)
Query Neighborhood Hits	332	Target Neighborhood Hits	1058	Shared Neighborhood Hits	175
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

JIP2_HUMAN
NC score	0.133629 (rank : 228)	θ value	0.62314 (rank : 212)
Query Neighborhood Hits	332	Target Neighborhood Hits	288	Shared Neighborhood Hits	70
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MPP2_HUMAN
NC score	0.132161 (rank : 229)	θ value	0.125558 (rank : 186)
Query Neighborhood Hits	332	Target Neighborhood Hits	173	Shared Neighborhood Hits	71
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

DAPP1_MOUSE
NC score	0.131951 (rank : 230)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

LYN_HUMAN
NC score	0.131486 (rank : 231)	θ value	0.62314 (rank : 214)
Query Neighborhood Hits	332	Target Neighborhood Hits	1022	Shared Neighborhood Hits	150
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MPP2_MOUSE
NC score	0.130876 (rank : 232)	θ value	0.365318 (rank : 199)
Query Neighborhood Hits	332	Target Neighborhood Hits	189	Shared Neighborhood Hits	70
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

DAPP1_HUMAN
NC score	0.129613 (rank : 233)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

LYN_MOUSE
NC score	0.128604 (rank : 234)	θ value	4.03905 (rank : 275)
Query Neighborhood Hits	332	Target Neighborhood Hits	1023	Shared Neighborhood Hits	150
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ARHGB_HUMAN
NC score	0.127404 (rank : 235)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	332	Target Neighborhood Hits	375	Shared Neighborhood Hits	40
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
NC score	0.126368 (rank : 236)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	332	Target Neighborhood Hits	351	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

P55G_HUMAN
NC score	0.125690 (rank : 237)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	332	Target Neighborhood Hits	451	Shared Neighborhood Hits	86
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

ARHG1_HUMAN
NC score	0.125594 (rank : 238)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	332	Target Neighborhood Hits	176	Shared Neighborhood Hits	23
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHGC_MOUSE
NC score	0.125473 (rank : 239)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	332	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BLK_HUMAN
NC score	0.125302 (rank : 240)	θ value	0.0563607 (rank : 174)
Query Neighborhood Hits	332	Target Neighborhood Hits	994	Shared Neighborhood Hits	136
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HAPIP_HUMAN
NC score	0.122369 (rank : 241)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	332	Target Neighborhood Hits	350	Shared Neighborhood Hits	61
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

P55G_MOUSE
NC score	0.122361 (rank : 242)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	332	Target Neighborhood Hits	401	Shared Neighborhood Hits	80
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

BLK_MOUSE
NC score	0.121369 (rank : 243)	θ value	0.0431538 (rank : 164)
Query Neighborhood Hits	332	Target Neighborhood Hits	992	Shared Neighborhood Hits	126
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BCR_HUMAN
NC score	0.121155 (rank : 244)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	332	Target Neighborhood Hits	204	Shared Neighborhood Hits	37
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

JIP1_HUMAN
NC score	0.120894 (rank : 245)	θ value	5.27518 (rank : 284)
Query Neighborhood Hits	332	Target Neighborhood Hits	271	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
NC score	0.119907 (rank : 246)	θ value	5.27518 (rank : 285)
Query Neighborhood Hits	332	Target Neighborhood Hits	259	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

RGNEF_MOUSE
NC score	0.119163 (rank : 247)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	332	Target Neighborhood Hits	641	Shared Neighborhood Hits	72
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

PTK6_MOUSE
NC score	0.116923 (rank : 248)	θ value	1.06291 (rank : 230)
Query Neighborhood Hits	332	Target Neighborhood Hits	1026	Shared Neighborhood Hits	150
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

GNRP_MOUSE
NC score	0.116368 (rank : 249)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	332	Target Neighborhood Hits	191	Shared Neighborhood Hits	31
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD4_MOUSE
NC score	0.115271 (rank : 250)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	33
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_MOUSE
NC score	0.114805 (rank : 251)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	332	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

TXK_MOUSE
NC score	0.114774 (rank : 252)	θ value	6.88961 (rank : 316)
Query Neighborhood Hits	332	Target Neighborhood Hits	980	Shared Neighborhood Hits	140
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

FGD4_HUMAN
NC score	0.114295 (rank : 253)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	332	Target Neighborhood Hits	219	Shared Neighborhood Hits	33
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

CSK_HUMAN
NC score	0.114142 (rank : 254)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	332	Target Neighborhood Hits	1009	Shared Neighborhood Hits	134
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.114104 (rank : 255)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	332	Target Neighborhood Hits	1009	Shared Neighborhood Hits	134
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

SHE_MOUSE
NC score	0.114028 (rank : 256)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	332	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PTK6_HUMAN
NC score	0.113662 (rank : 257)	θ value	0.62314 (rank : 216)
Query Neighborhood Hits	332	Target Neighborhood Hits	1020	Shared Neighborhood Hits	153
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

LBC_HUMAN
NC score	0.112632 (rank : 258)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	332	Target Neighborhood Hits	90	Shared Neighborhood Hits	23
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

FGD2_HUMAN
NC score	0.110256 (rank : 259)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	332	Target Neighborhood Hits	151	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

TEC_HUMAN
NC score	0.110067 (rank : 260)	θ value	1.81305 (rank : 247)
Query Neighborhood Hits	332	Target Neighborhood Hits	1006	Shared Neighborhood Hits	133
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LCK_HUMAN
NC score	0.109876 (rank : 261)	θ value	4.03905 (rank : 273)
Query Neighborhood Hits	332	Target Neighborhood Hits	987	Shared Neighborhood Hits	117
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

ABL1_MOUSE
NC score	0.109624 (rank : 262)	θ value	4.03905 (rank : 267)
Query Neighborhood Hits	332	Target Neighborhood Hits	1178	Shared Neighborhood Hits	140
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ARHG2_HUMAN
NC score	0.109358 (rank : 263)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	332	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG1_MOUSE
NC score	0.109333 (rank : 264)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	332	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

SHE_HUMAN
NC score	0.109249 (rank : 265)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	332	Target Neighborhood Hits	164	Shared Neighborhood Hits	47
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ABL1_HUMAN
NC score	0.109188 (rank : 266)	θ value	6.88961 (rank : 296)
Query Neighborhood Hits	332	Target Neighborhood Hits	1220	Shared Neighborhood Hits	138
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

LCK_MOUSE
NC score	0.109002 (rank : 267)	θ value	4.03905 (rank : 274)
Query Neighborhood Hits	332	Target Neighborhood Hits	981	Shared Neighborhood Hits	117
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SHC3_MOUSE
NC score	0.107862 (rank : 268)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	332	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

ARHG2_MOUSE
NC score	0.107416 (rank : 269)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	332	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

FGD3_HUMAN
NC score	0.107401 (rank : 270)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	332	Target Neighborhood Hits	249	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

RUSC2_HUMAN
NC score	0.106725 (rank : 271)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	332	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ABR_HUMAN
NC score	0.106448 (rank : 272)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	332	Target Neighborhood Hits	166	Shared Neighborhood Hits	37
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

TEC_MOUSE
NC score	0.106067 (rank : 273)	θ value	4.03905 (rank : 279)
Query Neighborhood Hits	332	Target Neighborhood Hits	1006	Shared Neighborhood Hits	134
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

APS_HUMAN
NC score	0.105930 (rank : 274)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	332	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GNRP_HUMAN
NC score	0.105877 (rank : 275)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	332	Target Neighborhood Hits	239	Shared Neighborhood Hits	35
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SHB_MOUSE
NC score	0.104944 (rank : 276)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	332	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

TXK_HUMAN
NC score	0.104781 (rank : 277)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	332	Target Neighborhood Hits	971	Shared Neighborhood Hits	124
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

FGD2_MOUSE
NC score	0.103669 (rank : 278)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	332	Target Neighborhood Hits	163	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

SH21B_MOUSE
NC score	0.102952 (rank : 279)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	332	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ABL2_HUMAN
NC score	0.102948 (rank : 280)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	332	Target Neighborhood Hits	1045	Shared Neighborhood Hits	120
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

MPP4_MOUSE
NC score	0.102376 (rank : 281)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	332	Target Neighborhood Hits	188	Shared Neighborhood Hits	65
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

SHC1_MOUSE
NC score	0.102164 (rank : 282)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	332	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHB_HUMAN
NC score	0.101653 (rank : 283)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	332	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
NC score	0.101638 (rank : 284)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	332	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHD_MOUSE
NC score	0.101626 (rank : 285)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	332	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC3_HUMAN
NC score	0.101050 (rank : 286)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	332	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

CHIN_MOUSE
NC score	0.101004 (rank : 287)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	332	Target Neighborhood Hits	229	Shared Neighborhood Hits	52
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SH21B_HUMAN
NC score	0.100442 (rank : 288)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	332	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

FGD1_HUMAN
NC score	0.100219 (rank : 289)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	332	Target Neighborhood Hits	367	Shared Neighborhood Hits	43
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SHD_HUMAN
NC score	0.100211 (rank : 290)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	332	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC2_MOUSE
NC score	0.099530 (rank : 291)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	332	Target Neighborhood Hits	144	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC2_HUMAN
NC score	0.099515 (rank : 292)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	332	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

PPIP2_HUMAN
NC score	0.099256 (rank : 293)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	332	Target Neighborhood Hits	254	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

GRB14_MOUSE
NC score	0.099017 (rank : 294)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	332	Target Neighborhood Hits	149	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

CHIN_HUMAN
NC score	0.098932 (rank : 295)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

GRB14_HUMAN
NC score	0.098645 (rank : 296)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	332	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ITK_HUMAN
NC score	0.097929 (rank : 297)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	332	Target Neighborhood Hits	1016	Shared Neighborhood Hits	128
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

FGD1_MOUSE
NC score	0.097057 (rank : 298)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	332	Target Neighborhood Hits	387	Shared Neighborhood Hits	42
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

CHIO_HUMAN
NC score	0.096724 (rank : 299)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	332	Target Neighborhood Hits	220	Shared Neighborhood Hits	47
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

LNK_HUMAN
NC score	0.096163 (rank : 300)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	332	Target Neighborhood Hits	151	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LCP2_MOUSE
NC score	0.095697 (rank : 301)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	332	Target Neighborhood Hits	177	Shared Neighborhood Hits	47
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_MOUSE
NC score	0.095544 (rank : 302)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	332	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

FARP2_MOUSE
NC score	0.094025 (rank : 303)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	332	Target Neighborhood Hits	209	Shared Neighborhood Hits	32
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PPIP2_MOUSE
NC score	0.093721 (rank : 304)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	332	Target Neighborhood Hits	308	Shared Neighborhood Hits	45
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

MPP4_HUMAN
NC score	0.091731 (rank : 305)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	332	Target Neighborhood Hits	205	Shared Neighborhood Hits	62
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

SH24A_HUMAN
NC score	0.091483 (rank : 306)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	332	Target Neighborhood Hits	455	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

FGD6_MOUSE
NC score	0.091476 (rank : 307)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	332	Target Neighborhood Hits	282	Shared Neighborhood Hits	38
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GRB7_MOUSE
NC score	0.090330 (rank : 308)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	332	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

ITK_MOUSE
NC score	0.090196 (rank : 309)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	332	Target Neighborhood Hits	985	Shared Neighborhood Hits	114
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

HSH2D_HUMAN
NC score	0.090063 (rank : 310)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	332	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

RUSC2_MOUSE
NC score	0.089437 (rank : 311)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	332	Target Neighborhood Hits	305	Shared Neighborhood Hits	74
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

LCP2_HUMAN
NC score	0.089298 (rank : 312)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	332	Target Neighborhood Hits	531	Shared Neighborhood Hits	63
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PKHG4_HUMAN
NC score	0.088922 (rank : 313)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	332	Target Neighborhood Hits	200	Shared Neighborhood Hits	25
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

RHG25_HUMAN
NC score	0.086065 (rank : 314)	θ value	0.00390308 (rank : 141)
Query Neighborhood Hits	332	Target Neighborhood Hits	550	Shared Neighborhood Hits	53
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG12_MOUSE
NC score	0.086034 (rank : 315)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	332	Target Neighborhood Hits	204	Shared Neighborhood Hits	55
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

FARP2_HUMAN
NC score	0.085220 (rank : 316)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	332	Target Neighborhood Hits	240	Shared Neighborhood Hits	30
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MPP3_HUMAN
NC score	0.084331 (rank : 317)	θ value	6.88961 (rank : 308)
Query Neighborhood Hits	332	Target Neighborhood Hits	171	Shared Neighborhood Hits	38
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

FARP1_HUMAN
NC score	0.084304 (rank : 318)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	332	Target Neighborhood Hits	241	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

SRMS_MOUSE
NC score	0.083588 (rank : 319)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	332	Target Neighborhood Hits	964	Shared Neighborhood Hits	100
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

APS_MOUSE
NC score	0.082473 (rank : 320)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	332	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

MPP3_MOUSE
NC score	0.082346 (rank : 321)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	332	Target Neighborhood Hits	165	Shared Neighborhood Hits	37
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

RHG09_HUMAN
NC score	0.082193 (rank : 322)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	332	Target Neighborhood Hits	186	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

SH2D3_MOUSE
NC score	0.081404 (rank : 323)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	332	Target Neighborhood Hits	174	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH22A_MOUSE
NC score	0.081298 (rank : 324)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	332	Target Neighborhood Hits	179	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

FGD6_HUMAN
NC score	0.081187 (rank : 325)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	332	Target Neighborhood Hits	237	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

GRB7_HUMAN
NC score	0.080751 (rank : 326)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	332	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

CSKP_HUMAN
NC score	0.080050 (rank : 327)	θ value	0.00175202 (rank : 125)
Query Neighborhood Hits	332	Target Neighborhood Hits	1022	Shared Neighborhood Hits	118
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DLG2_MOUSE
NC score	0.079937 (rank : 328)	θ value	8.99809 (rank : 320)
Query Neighborhood Hits	332	Target Neighborhood Hits	271	Shared Neighborhood Hits	77
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PTN11_MOUSE
NC score	0.079322 (rank : 329)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.079317 (rank : 330)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	332	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

S3TC2_MOUSE
NC score	0.079253 (rank : 331)	θ value	1.38821 (rank : 241)
Query Neighborhood Hits	332	Target Neighborhood Hits	83	Shared Neighborhood Hits	46
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

3BP1_HUMAN
NC score	0.078420 (rank : 332)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	332	Target Neighborhood Hits	376	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

FYB_HUMAN
NC score	0.078310 (rank : 333)	θ value	0.0563607 (rank : 175)
Query Neighborhood Hits	332	Target Neighborhood Hits	379	Shared Neighborhood Hits	45
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GRB10_MOUSE
NC score	0.078107 (rank : 334)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	332	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB10_HUMAN
NC score	0.077292 (rank : 335)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	332	Target Neighborhood Hits	147	Shared Neighborhood Hits	44
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

BLNK_MOUSE
NC score	0.077277 (rank : 336)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	332	Target Neighborhood Hits	296	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

DLG2_HUMAN
NC score	0.077195 (rank : 337)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	332	Target Neighborhood Hits	279	Shared Neighborhood Hits	77
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

CSKP_MOUSE
NC score	0.076938 (rank : 338)	θ value	0.0193708 (rank : 150)
Query Neighborhood Hits	332	Target Neighborhood Hits	1027	Shared Neighborhood Hits	125
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

RHG12_HUMAN
NC score	0.076504 (rank : 339)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	332	Target Neighborhood Hits	190	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

S3TC2_HUMAN
NC score	0.076303 (rank : 340)	θ value	1.06291 (rank : 233)
Query Neighborhood Hits	332	Target Neighborhood Hits	70	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

SH2D3_HUMAN
NC score	0.076212 (rank : 341)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	332	Target Neighborhood Hits	188	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH21A_HUMAN
NC score	0.076162 (rank : 342)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	332	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

BCAR3_HUMAN
NC score	0.075833 (rank : 343)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	332	Target Neighborhood Hits	129	Shared Neighborhood Hits	37
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

SH21A_MOUSE
NC score	0.075537 (rank : 344)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	332	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

TRIO_HUMAN
NC score	0.075403 (rank : 345)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	332	Target Neighborhood Hits	1580	Shared Neighborhood Hits	133
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SRMS_HUMAN
NC score	0.075065 (rank : 346)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	332	Target Neighborhood Hits	946	Shared Neighborhood Hits	79
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SH22A_HUMAN
NC score	0.074872 (rank : 347)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	332	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

BCAR3_MOUSE
NC score	0.073783 (rank : 348)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	332	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

EP15_MOUSE
NC score	0.073752 (rank : 349)	θ value	8.99809 (rank : 321)
Query Neighborhood Hits	332	Target Neighborhood Hits	820	Shared Neighborhood Hits	60
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

MATK_MOUSE
NC score	0.073431 (rank : 350)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	332	Target Neighborhood Hits	952	Shared Neighborhood Hits	83
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

EP15_HUMAN
NC score	0.072654 (rank : 351)	θ value	2.36792 (rank : 253)
Query Neighborhood Hits	332	Target Neighborhood Hits	1021	Shared Neighborhood Hits	68
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

DLG3_HUMAN
NC score	0.072485 (rank : 352)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	332	Target Neighborhood Hits	269	Shared Neighborhood Hits	75
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

RHG25_MOUSE
NC score	0.072374 (rank : 353)	θ value	4.03905 (rank : 278)
Query Neighborhood Hits	332	Target Neighborhood Hits	492	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

NACAM_MOUSE
NC score	0.071919 (rank : 354)	θ value	0.0961366 (rank : 184)
Query Neighborhood Hits	332	Target Neighborhood Hits	1866	Shared Neighborhood Hits	102
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

DLG3_MOUSE
NC score	0.071737 (rank : 355)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	332	Target Neighborhood Hits	274	Shared Neighborhood Hits	75
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG1_HUMAN
NC score	0.071561 (rank : 356)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	332	Target Neighborhood Hits	290	Shared Neighborhood Hits	73
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

MATK_HUMAN
NC score	0.071373 (rank : 357)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	332	Target Neighborhood Hits	954	Shared Neighborhood Hits	76
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

REPS2_HUMAN
NC score	0.070648 (rank : 358)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	332	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
NC score	0.070639 (rank : 359)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	332	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

EP15R_MOUSE
NC score	0.069578 (rank : 360)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	332	Target Neighborhood Hits	1135	Shared Neighborhood Hits	75
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

DLG4_HUMAN
NC score	0.068755 (rank : 361)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	332	Target Neighborhood Hits	286	Shared Neighborhood Hits	74
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

SOCS7_MOUSE
NC score	0.068531 (rank : 362)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	332	Target Neighborhood Hits	154	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

DLG1_MOUSE
NC score	0.068322 (rank : 363)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	332	Target Neighborhood Hits	285	Shared Neighborhood Hits	72
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

TXND2_HUMAN
NC score	0.068264 (rank : 364)	θ value	0.125558 (rank : 188)
Query Neighborhood Hits	332	Target Neighborhood Hits	793	Shared Neighborhood Hits	56
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

CHIO_MOUSE
NC score	0.067393 (rank : 365)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	332	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

FER_HUMAN
NC score	0.067317 (rank : 366)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	332	Target Neighborhood Hits	1278	Shared Neighborhood Hits	109
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

PTN6_MOUSE
NC score	0.067156 (rank : 367)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

AFF2_MOUSE
NC score	0.066982 (rank : 368)	θ value	0.00390308 (rank : 136)
Query Neighborhood Hits	332	Target Neighborhood Hits	225	Shared Neighborhood Hits	24
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

SOS1_HUMAN
NC score	0.066885 (rank : 369)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	332	Target Neighborhood Hits	274	Shared Neighborhood Hits	31
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SH23A_HUMAN
NC score	0.066613 (rank : 370)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	332	Target Neighborhood Hits	149	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

OPHN1_HUMAN
NC score	0.066604 (rank : 371)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	332	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

DLG4_MOUSE
NC score	0.066511 (rank : 372)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	332	Target Neighborhood Hits	282	Shared Neighborhood Hits	72
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

HSH2D_MOUSE
NC score	0.066101 (rank : 373)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	332	Target Neighborhood Hits	124	Shared Neighborhood Hits	27
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

PTN6_HUMAN
NC score	0.065990 (rank : 374)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	332	Target Neighborhood Hits	234	Shared Neighborhood Hits	51
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SMC3_MOUSE
NC score	0.065682 (rank : 375)	θ value	0.0431538 (rank : 173)
Query Neighborhood Hits	332	Target Neighborhood Hits	1187	Shared Neighborhood Hits	74
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

MY18A_HUMAN
NC score	0.065631 (rank : 376)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	332	Target Neighborhood Hits	1929	Shared Neighborhood Hits	112
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SMC3_HUMAN
NC score	0.065610 (rank : 377)	θ value	0.0431538 (rank : 172)
Query Neighborhood Hits	332	Target Neighborhood Hits	1186	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

MYH11_HUMAN
NC score	0.065281 (rank : 378)	θ value	0.47712 (rank : 208)
Query Neighborhood Hits	332	Target Neighborhood Hits	1806	Shared Neighborhood Hits	110
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PCLO_HUMAN
NC score	0.065046 (rank : 379)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	332	Target Neighborhood Hits	2046	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

REPS1_HUMAN
NC score	0.064331 (rank : 380)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	332	Target Neighborhood Hits	205	Shared Neighborhood Hits	26
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

BLNK_HUMAN
NC score	0.064327 (rank : 381)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	332	Target Neighborhood Hits	228	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

OPHN1_MOUSE
NC score	0.064135 (rank : 382)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	332	Target Neighborhood Hits	174	Shared Neighborhood Hits	26
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

EP15R_HUMAN
NC score	0.064076 (rank : 383)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	332	Target Neighborhood Hits	1083	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

SOS1_MOUSE
NC score	0.063698 (rank : 384)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	332	Target Neighborhood Hits	281	Shared Neighborhood Hits	31
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

MY18A_MOUSE
NC score	0.063427 (rank : 385)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	332	Target Neighborhood Hits	1989	Shared Neighborhood Hits	110
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH9_HUMAN
NC score	0.063007 (rank : 386)	θ value	5.27518 (rank : 290)
Query Neighborhood Hits	332	Target Neighborhood Hits	1762	Shared Neighborhood Hits	105
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SH24A_MOUSE
NC score	0.062756 (rank : 387)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	332	Target Neighborhood Hits	326	Shared Neighborhood Hits	56
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

MYH9_MOUSE
NC score	0.061914 (rank : 388)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	332	Target Neighborhood Hits	1829	Shared Neighborhood Hits	114
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH11_MOUSE
NC score	0.061902 (rank : 389)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	332	Target Neighborhood Hits	1777	Shared Neighborhood Hits	109
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

ACK1_MOUSE
NC score	0.061721 (rank : 390)	θ value	0.47712 (rank : 204)
Query Neighborhood Hits	332	Target Neighborhood Hits	1080	Shared Neighborhood Hits	96
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

REPS1_MOUSE
NC score	0.061409 (rank : 391)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	332	Target Neighborhood Hits	204	Shared Neighborhood Hits	22
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

TEX14_MOUSE
NC score	0.060995 (rank : 392)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	332	Target Neighborhood Hits	1333	Shared Neighborhood Hits	90
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

MYH1_MOUSE
NC score	0.060888 (rank : 393)	θ value	6.88961 (rank : 310)
Query Neighborhood Hits	332	Target Neighborhood Hits	1461	Shared Neighborhood Hits	90
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH8_HUMAN
NC score	0.060748 (rank : 394)	θ value	5.27518 (rank : 289)
Query Neighborhood Hits	332	Target Neighborhood Hits	1610	Shared Neighborhood Hits	99
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

DUET_HUMAN
NC score	0.060571 (rank : 395)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	332	Target Neighborhood Hits	1220	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

MYO9B_MOUSE
NC score	0.060565 (rank : 396)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	332	Target Neighborhood Hits	311	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

PLCB4_HUMAN
NC score	0.060414 (rank : 397)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	332	Target Neighborhood Hits	658	Shared Neighborhood Hits	58
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

MYO9B_HUMAN
NC score	0.060334 (rank : 398)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	332	Target Neighborhood Hits	641	Shared Neighborhood Hits	49
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

ACK1_HUMAN
NC score	0.060208 (rank : 399)	θ value	0.47712 (rank : 203)
Query Neighborhood Hits	332	Target Neighborhood Hits	1140	Shared Neighborhood Hits	90
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

MYH3_HUMAN
NC score	0.060090 (rank : 400)	θ value	8.99809 (rank : 326)
Query Neighborhood Hits	332	Target Neighborhood Hits	1660	Shared Neighborhood Hits	98
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

KSYK_MOUSE
NC score	0.060034 (rank : 401)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	332	Target Neighborhood Hits	944	Shared Neighborhood Hits	59
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MDC1_HUMAN
NC score	0.059966 (rank : 402)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	332	Target Neighborhood Hits	1446	Shared Neighborhood Hits	89
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

DLG5_HUMAN
NC score	0.059893 (rank : 403)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	332	Target Neighborhood Hits	1088	Shared Neighborhood Hits	112
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DDFL1_HUMAN
NC score	0.059890 (rank : 404)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	332	Target Neighborhood Hits	353	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

ZAP70_MOUSE
NC score	0.059888 (rank : 405)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	332	Target Neighborhood Hits	905	Shared Neighborhood Hits	57
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ERC2_MOUSE
NC score	0.059573 (rank : 406)	θ value	0.62314 (rank : 210)
Query Neighborhood Hits	332	Target Neighborhood Hits	1166	Shared Neighborhood Hits	85
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ZAP70_HUMAN
NC score	0.059489 (rank : 407)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	332	Target Neighborhood Hits	893	Shared Neighborhood Hits	57
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

DOCK2_MOUSE
NC score	0.059286 (rank : 408)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	332	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

CSKI2_MOUSE
NC score	0.059117 (rank : 409)	θ value	8.99809 (rank : 319)
Query Neighborhood Hits	332	Target Neighborhood Hits	812	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

MYH8_MOUSE
NC score	0.058855 (rank : 410)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	332	Target Neighborhood Hits	1600	Shared Neighborhood Hits	94
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SOCS6_MOUSE
NC score	0.058711 (rank : 411)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	332	Target Neighborhood Hits	146	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

MYH1_HUMAN
NC score	0.058641 (rank : 412)	θ value	8.99809 (rank : 325)
Query Neighborhood Hits	332	Target Neighborhood Hits	1478	Shared Neighborhood Hits	90
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

SOCS6_HUMAN
NC score	0.058600 (rank : 413)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	332	Target Neighborhood Hits	126	Shared Neighborhood Hits	33
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

KSYK_HUMAN
NC score	0.058441 (rank : 414)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	332	Target Neighborhood Hits	901	Shared Neighborhood Hits	56
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MYH4_MOUSE
NC score	0.058334 (rank : 415)	θ value	6.88961 (rank : 311)
Query Neighborhood Hits	332	Target Neighborhood Hits	1476	Shared Neighborhood Hits	94
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

SOCS2_MOUSE
NC score	0.057956 (rank : 416)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	332	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

MYH2_HUMAN
NC score	0.057904 (rank : 417)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	332	Target Neighborhood Hits	1491	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

ERC2_HUMAN
NC score	0.057873 (rank : 418)	θ value	0.62314 (rank : 209)
Query Neighborhood Hits	332	Target Neighborhood Hits	1156	Shared Neighborhood Hits	83
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

MYH10_MOUSE
NC score	0.057659 (rank : 419)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	332	Target Neighborhood Hits	1612	Shared Neighborhood Hits	98
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_HUMAN
NC score	0.057533 (rank : 420)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	332	Target Neighborhood Hits	1620	Shared Neighborhood Hits	98
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

DDFL1_MOUSE
NC score	0.057442 (rank : 421)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	332	Target Neighborhood Hits	324	Shared Neighborhood Hits	19
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

TEX14_HUMAN
NC score	0.057438 (rank : 422)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	332	Target Neighborhood Hits	1103	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

BMX_HUMAN
NC score	0.057287 (rank : 423)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	332	Target Neighborhood Hits	942	Shared Neighborhood Hits	55
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.057253 (rank : 424)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	332	Target Neighborhood Hits	912	Shared Neighborhood Hits	53
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

MYH13_HUMAN
NC score	0.056971 (rank : 425)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	332	Target Neighborhood Hits	1504	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYO15_MOUSE
NC score	0.056882 (rank : 426)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	332	Target Neighborhood Hits	467	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO5C_HUMAN
NC score	0.056824 (rank : 427)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	332	Target Neighborhood Hits	1206	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MY18B_HUMAN
NC score	0.056431 (rank : 428)	θ value	6.88961 (rank : 309)
Query Neighborhood Hits	332	Target Neighborhood Hits	1299	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

PLCB3_HUMAN
NC score	0.056175 (rank : 429)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	332	Target Neighborhood Hits	445	Shared Neighborhood Hits	49
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

DOCK2_HUMAN
NC score	0.056043 (rank : 430)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	332	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

PLCB1_HUMAN
NC score	0.056015 (rank : 431)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	332	Target Neighborhood Hits	614	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

3BP1_MOUSE
NC score	0.055796 (rank : 432)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	332	Target Neighborhood Hits	238	Shared Neighborhood Hits	33
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

MYO10_HUMAN
NC score	0.055759 (rank : 433)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	332	Target Neighborhood Hits	920	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

ILK1_HUMAN
NC score	0.055740 (rank : 434)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	332	Target Neighborhood Hits	857	Shared Neighborhood Hits	50
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.055698 (rank : 435)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	332	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INCE_HUMAN
NC score	0.055614 (rank : 436)	θ value	4.03905 (rank : 272)
Query Neighborhood Hits	332	Target Neighborhood Hits	978	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

ILK2_HUMAN
NC score	0.055457 (rank : 437)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	332	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

MYH14_MOUSE
NC score	0.055344 (rank : 438)	θ value	2.36792 (rank : 255)
Query Neighborhood Hits	332	Target Neighborhood Hits	1225	Shared Neighborhood Hits	76
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PLCB2_HUMAN
NC score	0.055237 (rank : 439)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	332	Target Neighborhood Hits	608	Shared Neighborhood Hits	56
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

EEA1_HUMAN
NC score	0.055199 (rank : 440)	θ value	0.47712 (rank : 205)
Query Neighborhood Hits	332	Target Neighborhood Hits	1796	Shared Neighborhood Hits	100
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

CSKI1_HUMAN
NC score	0.055124 (rank : 441)	θ value	5.27518 (rank : 282)
Query Neighborhood Hits	332	Target Neighborhood Hits	997	Shared Neighborhood Hits	86
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MYH14_HUMAN
NC score	0.055058 (rank : 442)	θ value	0.813845 (rank : 220)
Query Neighborhood Hits	332	Target Neighborhood Hits	995	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

LMO7_HUMAN
NC score	0.054974 (rank : 443)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	332	Target Neighborhood Hits	507	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

SOCS2_HUMAN
NC score	0.054940 (rank : 444)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	332	Target Neighborhood Hits	104	Shared Neighborhood Hits	32
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

CSKI2_HUMAN
NC score	0.054810 (rank : 445)	θ value	8.99809 (rank : 318)
Query Neighborhood Hits	332	Target Neighborhood Hits	747	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

MYH4_HUMAN
NC score	0.054702 (rank : 446)	θ value	8.99809 (rank : 327)
Query Neighborhood Hits	332	Target Neighborhood Hits	1377	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH6_MOUSE
NC score	0.054590 (rank : 447)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	332	Target Neighborhood Hits	1501	Shared Neighborhood Hits	89
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

INCE_MOUSE
NC score	0.054416 (rank : 448)	θ value	3.0926 (rank : 263)
Query Neighborhood Hits	332	Target Neighborhood Hits	903	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

HGS_HUMAN
NC score	0.054173 (rank : 449)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	332	Target Neighborhood Hits	517	Shared Neighborhood Hits	43
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

MYH7_HUMAN
NC score	0.053718 (rank : 450)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	332	Target Neighborhood Hits	1559	Shared Neighborhood Hits	87
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

RBP1_HUMAN
NC score	0.053633 (rank : 451)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	332	Target Neighborhood Hits	521	Shared Neighborhood Hits	56
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
NC score	0.053377 (rank : 452)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	332	Target Neighborhood Hits	493	Shared Neighborhood Hits	58
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

GAS7_HUMAN
NC score	0.052949 (rank : 453)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	332	Target Neighborhood Hits	258	Shared Neighborhood Hits	40
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

MYO5A_HUMAN
NC score	0.052897 (rank : 454)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	332	Target Neighborhood Hits	1092	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MYH6_HUMAN
NC score	0.052864 (rank : 455)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	332	Target Neighborhood Hits	1426	Shared Neighborhood Hits	83
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

PCNT_HUMAN
NC score	0.052768 (rank : 456)	θ value	6.88961 (rank : 314)
Query Neighborhood Hits	332	Target Neighborhood Hits	1551	Shared Neighborhood Hits	102
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

MYO15_HUMAN
NC score	0.052679 (rank : 457)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	332	Target Neighborhood Hits	671	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

CCD46_HUMAN
NC score	0.052638 (rank : 458)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	332	Target Neighborhood Hits	1430	Shared Neighborhood Hits	93
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

EEA1_MOUSE
NC score	0.052603 (rank : 459)	θ value	1.81305 (rank : 245)
Query Neighborhood Hits	332	Target Neighborhood Hits	1637	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MYO6_MOUSE
NC score	0.052477 (rank : 460)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	332	Target Neighborhood Hits	586	Shared Neighborhood Hits	47
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

CSKI1_MOUSE
NC score	0.052359 (rank : 461)	θ value	5.27518 (rank : 283)
Query Neighborhood Hits	332	Target Neighborhood Hits	1031	Shared Neighborhood Hits	79
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

HGS_MOUSE
NC score	0.052145 (rank : 462)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	332	Target Neighborhood Hits	589	Shared Neighborhood Hits	46
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

PLCD1_MOUSE
NC score	0.052093 (rank : 463)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	332	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

MYO6_HUMAN
NC score	0.052001 (rank : 464)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	332	Target Neighborhood Hits	727	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

CENPF_HUMAN
NC score	0.051834 (rank : 465)	θ value	4.03905 (rank : 271)
Query Neighborhood Hits	332	Target Neighborhood Hits	1932	Shared Neighborhood Hits	109
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

RGAP1_MOUSE
NC score	0.051739 (rank : 466)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	332	Target Neighborhood Hits	185	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

FLIP1_HUMAN
NC score	0.051607 (rank : 467)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	332	Target Neighborhood Hits	1405	Shared Neighborhood Hits	92
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

ANK2_HUMAN
NC score	0.051207 (rank : 468)	θ value	0.00175202 (rank : 124)
Query Neighborhood Hits	332	Target Neighborhood Hits	1615	Shared Neighborhood Hits	90
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ENAH_MOUSE
NC score	0.051023 (rank : 469)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	332	Target Neighborhood Hits	919	Shared Neighborhood Hits	72
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

S3TC1_HUMAN
NC score	0.050894 (rank : 470)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	332	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

NIN_HUMAN
NC score	0.050678 (rank : 471)	θ value	0.813845 (rank : 221)
Query Neighborhood Hits	332	Target Neighborhood Hits	1416	Shared Neighborhood Hits	78
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

PLCB1_MOUSE
NC score	0.050565 (rank : 472)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	332	Target Neighborhood Hits	531	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

MUC7_HUMAN
NC score	0.050544 (rank : 473)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	332	Target Neighborhood Hits	538	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

ECM1_MOUSE
NC score	0.050527 (rank : 474)	θ value	0.279714 (rank : 192)
Query Neighborhood Hits	332	Target Neighborhood Hits	105	Shared Neighborhood Hits	13
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

FYB_MOUSE
NC score	0.050526 (rank : 475)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	332	Target Neighborhood Hits	194	Shared Neighborhood Hits	34
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

MYO5A_MOUSE
NC score	0.050404 (rank : 476)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	332	Target Neighborhood Hits	1117	Shared Neighborhood Hits	74
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO7A_MOUSE
NC score	0.050389 (rank : 477)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	332	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

CEP63_HUMAN
NC score	0.050353 (rank : 478)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	332	Target Neighborhood Hits	1005	Shared Neighborhood Hits	77
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

KGUA_MOUSE
NC score	0.050351 (rank : 479)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	332	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

CI093_HUMAN
NC score	0.050268 (rank : 480)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	332	Target Neighborhood Hits	1088	Shared Neighborhood Hits	78
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

BIN3_MOUSE
NC score	0.050216 (rank : 481)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	332	Target Neighborhood Hits	165	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JI08	Gene names	Bin3
Domain Architecture	No domain graphic available
Description	Bridging integrator 3.

CP250_HUMAN
NC score	0.050210 (rank : 482)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	332	Target Neighborhood Hits	1805	Shared Neighborhood Hits	92
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

NIN_MOUSE
NC score	0.049997 (rank : 483)	θ value	0.813845 (rank : 222)
Query Neighborhood Hits	332	Target Neighborhood Hits	1376	Shared Neighborhood Hits	80
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

REST_HUMAN
NC score	0.049450 (rank : 484)	θ value	1.38821 (rank : 240)
Query Neighborhood Hits	332	Target Neighborhood Hits	1605	Shared Neighborhood Hits	92
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

MDC1_MOUSE
NC score	0.048791 (rank : 485)	θ value	0.47712 (rank : 207)
Query Neighborhood Hits	332	Target Neighborhood Hits	998	Shared Neighborhood Hits	61
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NUMA1_HUMAN
NC score	0.048175 (rank : 486)	θ value	4.03905 (rank : 277)
Query Neighborhood Hits	332	Target Neighborhood Hits	1523	Shared Neighborhood Hits	92
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

TARA_HUMAN
NC score	0.047341 (rank : 487)	θ value	0.813845 (rank : 224)
Query Neighborhood Hits	332	Target Neighborhood Hits	1626	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

LIPA2_MOUSE
NC score	0.046268 (rank : 488)	θ value	5.27518 (rank : 288)
Query Neighborhood Hits	332	Target Neighborhood Hits	1282	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

TRHY_HUMAN
NC score	0.045930 (rank : 489)	θ value	5.27518 (rank : 294)
Query Neighborhood Hits	332	Target Neighborhood Hits	1385	Shared Neighborhood Hits	84
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

PWWP2_HUMAN
NC score	0.045859 (rank : 490)	θ value	1.06291 (rank : 231)
Query Neighborhood Hits	332	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NUJ5, Q5SZI0, Q6ZQX5, Q96F43	Gene names	PWWP2
Domain Architecture	No domain graphic available
Description	PWWP domain-containing protein 2.

CP135_HUMAN
NC score	0.045697 (rank : 491)	θ value	6.88961 (rank : 300)
Query Neighborhood Hits	332	Target Neighborhood Hits	1290	Shared Neighborhood Hits	82
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

APOE_MOUSE
NC score	0.045319 (rank : 492)	θ value	4.03905 (rank : 268)
Query Neighborhood Hits	332	Target Neighborhood Hits	319	Shared Neighborhood Hits	40
SwissProt Accessions	P08226	Gene names	Apoe
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

MAGE1_HUMAN
NC score	0.045308 (rank : 493)	θ value	0.00665767 (rank : 145)
Query Neighborhood Hits	332	Target Neighborhood Hits	1389	Shared Neighborhood Hits	67
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

GRIN1_MOUSE
NC score	0.045169 (rank : 494)	θ value	0.365318 (rank : 197)
Query Neighborhood Hits	332	Target Neighborhood Hits	337	Shared Neighborhood Hits	26
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

MACOI_HUMAN
NC score	0.044551 (rank : 495)	θ value	8.99809 (rank : 324)
Query Neighborhood Hits	332	Target Neighborhood Hits	650	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

REST_MOUSE
NC score	0.044327 (rank : 496)	θ value	1.06291 (rank : 232)
Query Neighborhood Hits	332	Target Neighborhood Hits	1506	Shared Neighborhood Hits	85
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

HOME2_MOUSE
NC score	0.044150 (rank : 497)	θ value	6.88961 (rank : 302)
Query Neighborhood Hits	332	Target Neighborhood Hits	882	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

CCD27_MOUSE
NC score	0.044019 (rank : 498)	θ value	4.03905 (rank : 269)
Query Neighborhood Hits	332	Target Neighborhood Hits	461	Shared Neighborhood Hits	46
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

RFIP4_HUMAN
NC score	0.043271 (rank : 499)	θ value	5.27518 (rank : 291)
Query Neighborhood Hits	332	Target Neighborhood Hits	785	Shared Neighborhood Hits	62
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

MACOI_MOUSE
NC score	0.043036 (rank : 500)	θ value	6.88961 (rank : 305)
Query Neighborhood Hits	332	Target Neighborhood Hits	620	Shared Neighborhood Hits	58
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MAP1B_MOUSE
NC score	0.042345 (rank : 501)	θ value	6.88961 (rank : 306)
Query Neighborhood Hits	332	Target Neighborhood Hits	977	Shared Neighborhood Hits	77
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

IF2P_HUMAN
NC score	0.041436 (rank : 502)	θ value	6.88961 (rank : 303)
Query Neighborhood Hits	332	Target Neighborhood Hits	889	Shared Neighborhood Hits	70
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

COA2_HUMAN
NC score	0.041095 (rank : 503)	θ value	0.0431538 (rank : 165)
Query Neighborhood Hits	332	Target Neighborhood Hits	184	Shared Neighborhood Hits	9
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

PKCB1_HUMAN
NC score	0.040503 (rank : 504)	θ value	0.125558 (rank : 187)
Query Neighborhood Hits	332	Target Neighborhood Hits	488	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

EVPL_MOUSE
NC score	0.040379 (rank : 505)	θ value	3.0926 (rank : 260)
Query Neighborhood Hits	332	Target Neighborhood Hits	952	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

MGRN1_HUMAN
NC score	0.040183 (rank : 506)	θ value	0.365318 (rank : 198)
Query Neighborhood Hits	332	Target Neighborhood Hits	192	Shared Neighborhood Hits	6
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MLL3_MOUSE
NC score	0.040058 (rank : 507)	θ value	0.125558 (rank : 185)
Query Neighborhood Hits	332	Target Neighborhood Hits	1399	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MLL3_HUMAN
NC score	0.039729 (rank : 508)	θ value	4.03905 (rank : 276)
Query Neighborhood Hits	332	Target Neighborhood Hits	1644	Shared Neighborhood Hits	81
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

AFF2_HUMAN
NC score	0.039407 (rank : 509)	θ value	5.27518 (rank : 281)
Query Neighborhood Hits	332	Target Neighborhood Hits	218	Shared Neighborhood Hits	21
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

PCP2_MOUSE
NC score	0.037763 (rank : 510)	θ value	1.38821 (rank : 239)
Query Neighborhood Hits	332	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	P12660, P22941, Q3TV53	Gene names	Pcp2, Pcp-2
Domain Architecture
Description	Purkinje cell protein 2 (Protein PCD-5) (Purkinje cell-specific protein L7).

FA47A_HUMAN
NC score	0.037481 (rank : 511)	θ value	3.0926 (rank : 261)
Query Neighborhood Hits	332	Target Neighborhood Hits	451	Shared Neighborhood Hits	35
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

CSF1_HUMAN
NC score	0.037179 (rank : 512)	θ value	1.06291 (rank : 227)
Query Neighborhood Hits	332	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

C102B_HUMAN
NC score	0.036721 (rank : 513)	θ value	3.0926 (rank : 258)
Query Neighborhood Hits	332	Target Neighborhood Hits	542	Shared Neighborhood Hits	44
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

STMN3_MOUSE
NC score	0.035178 (rank : 514)	θ value	1.38821 (rank : 243)
Query Neighborhood Hits	332	Target Neighborhood Hits	331	Shared Neighborhood Hits	38
SwissProt Accessions	O70166	Gene names	Stmn3, Sclip
Domain Architecture
Description	Stathmin-3 (SCG10-like protein) (SCG10-related protein HiAT3) (Hippocampus abundant transcript 3).

TMCC1_HUMAN
NC score	0.033466 (rank : 515)	θ value	1.06291 (rank : 235)
Query Neighborhood Hits	332	Target Neighborhood Hits	337	Shared Neighborhood Hits	36
SwissProt Accessions	O94876, Q68E06, Q8IXM8	Gene names	TMCC1, KIAA0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

BSN_HUMAN
NC score	0.031891 (rank : 516)	θ value	6.88961 (rank : 297)
Query Neighborhood Hits	332	Target Neighborhood Hits	1537	Shared Neighborhood Hits	95
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

ZO1_MOUSE
NC score	0.031344 (rank : 517)	θ value	0.365318 (rank : 202)
Query Neighborhood Hits	332	Target Neighborhood Hits	453	Shared Neighborhood Hits	38
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

TMCC1_MOUSE
NC score	0.030380 (rank : 518)	θ value	1.81305 (rank : 248)
Query Neighborhood Hits	332	Target Neighborhood Hits	315	Shared Neighborhood Hits	32
SwissProt Accessions	Q69ZZ6, Q8CEF4	Gene names	Tmcc1, Kiaa0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

CIZ1_HUMAN
NC score	0.029790 (rank : 519)	θ value	6.88961 (rank : 298)
Query Neighborhood Hits	332	Target Neighborhood Hits	359	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

QSCN6_HUMAN
NC score	0.029184 (rank : 520)	θ value	0.813845 (rank : 223)
Query Neighborhood Hits	332	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

ALO17_HUMAN
NC score	0.028817 (rank : 521)	θ value	2.36792 (rank : 249)
Query Neighborhood Hits	332	Target Neighborhood Hits	317	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HCF4, Q69YK7, Q8IWF4, Q8IZX1, Q8IZX2, Q8N406	Gene names	KIAA1618, ALO17
Domain Architecture	No domain graphic available
Description	Protein ALO17 (ALK lymphoma oligomerization partner on chromosome 17).

SON_MOUSE
NC score	0.028357 (rank : 522)	θ value	3.0926 (rank : 266)
Query Neighborhood Hits	332	Target Neighborhood Hits	957	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

GNL3_MOUSE
NC score	0.027652 (rank : 523)	θ value	2.36792 (rank : 254)
Query Neighborhood Hits	332	Target Neighborhood Hits	99	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CI11, Q811R9, Q811S8, Q8BK21	Gene names	Gnl3, Ns
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin).

K1802_HUMAN
NC score	0.027228 (rank : 524)	θ value	0.279714 (rank : 193)
Query Neighborhood Hits	332	Target Neighborhood Hits	1378	Shared Neighborhood Hits	56
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LBXCO_MOUSE
NC score	0.026382 (rank : 525)	θ value	5.27518 (rank : 287)
Query Neighborhood Hits	332	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

ANK1_HUMAN
NC score	0.026107 (rank : 526)	θ value	8.99809 (rank : 317)
Query Neighborhood Hits	332	Target Neighborhood Hits	416	Shared Neighborhood Hits	21
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

LBXCO_HUMAN
NC score	0.025888 (rank : 527)	θ value	5.27518 (rank : 286)
Query Neighborhood Hits	332	Target Neighborhood Hits	167	Shared Neighborhood Hits	18
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

CD2_HUMAN
NC score	0.025886 (rank : 528)	θ value	1.81305 (rank : 244)
Query Neighborhood Hits	332	Target Neighborhood Hits	504	Shared Neighborhood Hits	26
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

GNL3_HUMAN
NC score	0.025601 (rank : 529)	θ value	1.06291 (rank : 228)
Query Neighborhood Hits	332	Target Neighborhood Hits	83	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BVP2, Q96SV6, Q96SV7, Q9UJY0	Gene names	GNL3, E2IG3, NS
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin) (E2-induced gene 3-protein) (Novel nucleolar protein 47) (NNP47).

PDZD2_HUMAN
NC score	0.025252 (rank : 530)	θ value	8.99809 (rank : 329)
Query Neighborhood Hits	332	Target Neighborhood Hits	772	Shared Neighborhood Hits	49
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

WDR67_MOUSE
NC score	0.024707 (rank : 531)	θ value	8.99809 (rank : 332)
Query Neighborhood Hits	332	Target Neighborhood Hits	476	Shared Neighborhood Hits	42
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

HM2L1_HUMAN
NC score	0.023579 (rank : 532)	θ value	3.0926 (rank : 262)
Query Neighborhood Hits	332	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGU5, O75672, O75673, Q9UMT5	Gene names	HMG2L1, HMGBCG
Domain Architecture
Description	High mobility group protein 2-like 1 (Protein HMGBCG).

NOG1_HUMAN
NC score	0.022415 (rank : 533)	θ value	6.88961 (rank : 313)
Query Neighborhood Hits	332	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BZE4, O95446, Q9NVJ8	Gene names	GTPBP4, CRFG, NOG1
Domain Architecture
Description	Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB).

AIM1_HUMAN
NC score	0.021973 (rank : 534)	θ value	1.06291 (rank : 225)
Query Neighborhood Hits	332	Target Neighborhood Hits	247	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

SETD2_HUMAN
NC score	0.021748 (rank : 535)	θ value	2.36792 (rank : 257)
Query Neighborhood Hits	332	Target Neighborhood Hits	412	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

S23IP_MOUSE
NC score	0.021678 (rank : 536)	θ value	5.27518 (rank : 292)
Query Neighborhood Hits	332	Target Neighborhood Hits	363	Shared Neighborhood Hits	26
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

NFH_HUMAN
NC score	0.020313 (rank : 537)	θ value	6.88961 (rank : 312)
Query Neighborhood Hits	332	Target Neighborhood Hits	1242	Shared Neighborhood Hits	86
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

S39A6_MOUSE
NC score	0.018543 (rank : 538)	θ value	2.36792 (rank : 256)
Query Neighborhood Hits	332	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C145, Q7TPP9, Q7TQE0, Q8R518	Gene names	Slc39a6
Domain Architecture	No domain graphic available
Description	Zinc transporter SLC39A6 precursor (Solute carrier family 39 member 6) (Endoplasmic reticulum membrane-linked protein) (Ermelin).

CJ012_HUMAN
NC score	0.018441 (rank : 539)	θ value	6.88961 (rank : 299)
Query Neighborhood Hits	332	Target Neighborhood Hits	467	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CN037_HUMAN
NC score	0.017471 (rank : 540)	θ value	2.36792 (rank : 251)
Query Neighborhood Hits	332	Target Neighborhood Hits	118	Shared Neighborhood Hits	7
SwissProt Accessions	Q86TY3, Q6P5Q1, Q86TY1	Gene names	C14orf37
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf37 precursor.

NCOR1_HUMAN
NC score	0.016367 (rank : 541)	θ value	8.99809 (rank : 328)
Query Neighborhood Hits	332	Target Neighborhood Hits	577	Shared Neighborhood Hits	38
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

GP179_HUMAN
NC score	0.016066 (rank : 542)	θ value	1.38821 (rank : 237)
Query Neighborhood Hits	332	Target Neighborhood Hits	372	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PRD1	Gene names	GPR179, GPR158L1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 179 precursor (Probable G-protein coupled receptor 158-like 1).

MAP2_MOUSE
NC score	0.015882 (rank : 543)	θ value	6.88961 (rank : 307)
Query Neighborhood Hits	332	Target Neighborhood Hits	342	Shared Neighborhood Hits	28
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

KIF3A_MOUSE
NC score	0.015499 (rank : 544)	θ value	8.99809 (rank : 323)
Query Neighborhood Hits	332	Target Neighborhood Hits	715	Shared Neighborhood Hits	57
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

TRI39_HUMAN
NC score	0.015103 (rank : 545)	θ value	0.62314 (rank : 218)
Query Neighborhood Hits	332	Target Neighborhood Hits	693	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

REV1_HUMAN
NC score	0.015024 (rank : 546)	θ value	3.0926 (rank : 264)
Query Neighborhood Hits	332	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBZ9, O95941, Q9C0J4, Q9NUP2	Gene names	REV1L, REV1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) (Alpha integrin-binding protein 80) (AIBP80).

KIF3A_HUMAN
NC score	0.014378 (rank : 547)	θ value	8.99809 (rank : 322)
Query Neighborhood Hits	332	Target Neighborhood Hits	704	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

ZF106_MOUSE
NC score	0.013617 (rank : 548)	θ value	1.06291 (rank : 236)
Query Neighborhood Hits	332	Target Neighborhood Hits	472	Shared Neighborhood Hits	24
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

TRI39_MOUSE
NC score	0.011882 (rank : 549)	θ value	4.03905 (rank : 280)
Query Neighborhood Hits	332	Target Neighborhood Hits	691	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

IL3B2_MOUSE
NC score	0.010875 (rank : 550)	θ value	6.88961 (rank : 304)
Query Neighborhood Hits	332	Target Neighborhood Hits	372	Shared Neighborhood Hits	17
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

CCNT1_HUMAN
NC score	0.010324 (rank : 551)	θ value	3.0926 (rank : 259)
Query Neighborhood Hits	332	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	O60563, O60581	Gene names	CCNT1
Domain Architecture
Description	Cyclin-T1 (CycT1) (Cyclin-T).

SMCA5_MOUSE
NC score	0.009551 (rank : 552)	θ value	5.27518 (rank : 293)
Query Neighborhood Hits	332	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZW3, Q8C791, Q8CA22, Q8VDG1, Q925M9	Gene names	Smarca5, Snf2h
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.1.-) (Sucrose nonfermenting protein 2 homolog) (mSnf2h).

SMCA5_HUMAN
NC score	0.009082 (rank : 553)	θ value	8.99809 (rank : 331)
Query Neighborhood Hits	332	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	O60264	Gene names	SMARCA5, SNF2H, WCRF135
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.1.-) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin A5) (Sucrose nonfermenting protein 2 homolog) (hSNF2H).

SMCA1_MOUSE
NC score	0.008204 (rank : 554)	θ value	3.0926 (rank : 265)
Query Neighborhood Hits	332	Target Neighborhood Hits	117	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PGB8, Q8BSS1, Q91Y58	Gene names	Smarca1, Snf2l
Domain Architecture	No domain graphic available
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) (DNA-dependent ATPase SNF2L).

ZP1_MOUSE
NC score	0.007946 (rank : 555)	θ value	5.27518 (rank : 295)
Query Neighborhood Hits	332	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q62005, Q62016	Gene names	Zp1
Domain Architecture
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

SMCA1_HUMAN
NC score	0.007193 (rank : 556)	θ value	8.99809 (rank : 330)
Query Neighborhood Hits	332	Target Neighborhood Hits	105	Shared Neighborhood Hits	12
SwissProt Accessions	P28370, Q5JV41, Q5JV42	Gene names	SMARCA1, SNF2L, SNF2L1
Domain Architecture
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1).

CD45_HUMAN
NC score	0.005017 (rank : 557)	θ value	4.03905 (rank : 270)
Query Neighborhood Hits	332	Target Neighborhood Hits	243	Shared Neighborhood Hits	11
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

DCC_MOUSE
NC score	0.003938 (rank : 558)	θ value	2.36792 (rank : 252)
Query Neighborhood Hits	332	Target Neighborhood Hits	896	Shared Neighborhood Hits	30
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).