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Network neighborhood for query Sequence : MPP6_MOUSE

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MPP6_MOUSE
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MPP2_HUMAN
θ value	0 (rank : 1)	NC score	0.983789 (rank : 3)
Query Neighborhood Hits	187	Target Neighborhood Hits	173	Shared Neighborhood Hits	143
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	0 (rank : 2)	NC score	0.983279 (rank : 4)
Query Neighborhood Hits	187	Target Neighborhood Hits	189	Shared Neighborhood Hits	148
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP6_HUMAN
θ value	0 (rank : 3)	NC score	0.998580 (rank : 2)
Query Neighborhood Hits	187	Target Neighborhood Hits	180	Shared Neighborhood Hits	179
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	187	Target Neighborhood Hits	187	Shared Neighborhood Hits	187
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

CSKP_HUMAN
θ value	7.12574e-114 (rank : 5)	NC score	0.344022 (rank : 44)
Query Neighborhood Hits	187	Target Neighborhood Hits	1022	Shared Neighborhood Hits	160
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	8.43692e-107 (rank : 6)	NC score	0.335615 (rank : 47)
Query Neighborhood Hits	187	Target Neighborhood Hits	1027	Shared Neighborhood Hits	159
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

EM55_HUMAN
θ value	7.91507e-97 (rank : 7)	NC score	0.957079 (rank : 5)
Query Neighborhood Hits	187	Target Neighborhood Hits	228	Shared Neighborhood Hits	157
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

MPP5_HUMAN
θ value	1.94955e-95 (rank : 8)	NC score	0.940702 (rank : 8)
Query Neighborhood Hits	187	Target Neighborhood Hits	231	Shared Neighborhood Hits	150
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	5.67233e-95 (rank : 9)	NC score	0.940942 (rank : 7)
Query Neighborhood Hits	187	Target Neighborhood Hits	226	Shared Neighborhood Hits	150
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

EM55_MOUSE
θ value	4.80189e-94 (rank : 10)	NC score	0.955400 (rank : 6)
Query Neighborhood Hits	187	Target Neighborhood Hits	221	Shared Neighborhood Hits	154
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MPP3_HUMAN
θ value	7.95186e-81 (rank : 11)	NC score	0.929639 (rank : 9)
Query Neighborhood Hits	187	Target Neighborhood Hits	171	Shared Neighborhood Hits	122
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	1.83746e-69 (rank : 12)	NC score	0.922629 (rank : 10)
Query Neighborhood Hits	187	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

DLG2_HUMAN
θ value	6.58091e-43 (rank : 13)	NC score	0.749079 (rank : 16)
Query Neighborhood Hits	187	Target Neighborhood Hits	279	Shared Neighborhood Hits	148
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
θ value	3.26607e-42 (rank : 14)	NC score	0.750487 (rank : 15)
Query Neighborhood Hits	187	Target Neighborhood Hits	269	Shared Neighborhood Hits	143
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG2_MOUSE
θ value	2.76489e-41 (rank : 15)	NC score	0.748272 (rank : 17)
Query Neighborhood Hits	187	Target Neighborhood Hits	271	Shared Neighborhood Hits	148
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_MOUSE
θ value	6.15952e-41 (rank : 16)	NC score	0.746950 (rank : 18)
Query Neighborhood Hits	187	Target Neighborhood Hits	274	Shared Neighborhood Hits	143
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG1_MOUSE
θ value	3.99248e-40 (rank : 17)	NC score	0.739334 (rank : 19)
Query Neighborhood Hits	187	Target Neighborhood Hits	285	Shared Neighborhood Hits	137
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG1_HUMAN
θ value	5.21438e-40 (rank : 18)	NC score	0.738073 (rank : 20)
Query Neighborhood Hits	187	Target Neighborhood Hits	290	Shared Neighborhood Hits	135
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

MPP4_MOUSE
θ value	1.28434e-38 (rank : 19)	NC score	0.889907 (rank : 11)
Query Neighborhood Hits	187	Target Neighborhood Hits	188	Shared Neighborhood Hits	128
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

DLG4_HUMAN
θ value	3.73686e-38 (rank : 20)	NC score	0.726710 (rank : 21)
Query Neighborhood Hits	187	Target Neighborhood Hits	286	Shared Neighborhood Hits	133
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	3.73686e-38 (rank : 21)	NC score	0.725963 (rank : 22)
Query Neighborhood Hits	187	Target Neighborhood Hits	282	Shared Neighborhood Hits	133
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

MPP4_HUMAN
θ value	2.42216e-37 (rank : 22)	NC score	0.865610 (rank : 14)
Query Neighborhood Hits	187	Target Neighborhood Hits	205	Shared Neighborhood Hits	131
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

KGUA_MOUSE
θ value	2.12685e-25 (rank : 23)	NC score	0.872910 (rank : 12)
Query Neighborhood Hits	187	Target Neighborhood Hits	45	Shared Neighborhood Hits	32
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_HUMAN
θ value	1.99067e-23 (rank : 24)	NC score	0.868453 (rank : 13)
Query Neighborhood Hits	187	Target Neighborhood Hits	41	Shared Neighborhood Hits	30
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

ZO3_MOUSE
θ value	7.59969e-07 (rank : 25)	NC score	0.463026 (rank : 24)
Query Neighborhood Hits	187	Target Neighborhood Hits	224	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_HUMAN
θ value	1.29631e-06 (rank : 26)	NC score	0.469015 (rank : 23)
Query Neighborhood Hits	187	Target Neighborhood Hits	219	Shared Neighborhood Hits	90
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ITSN1_MOUSE
θ value	4.92598e-06 (rank : 27)	NC score	0.136940 (rank : 166)
Query Neighborhood Hits	187	Target Neighborhood Hits	1669	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DLG5_HUMAN
θ value	6.43352e-06 (rank : 28)	NC score	0.379869 (rank : 38)
Query Neighborhood Hits	187	Target Neighborhood Hits	1088	Shared Neighborhood Hits	126
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ITSN1_HUMAN
θ value	1.09739e-05 (rank : 29)	NC score	0.134886 (rank : 168)
Query Neighborhood Hits	187	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ZO2_MOUSE
θ value	1.09739e-05 (rank : 30)	NC score	0.442953 (rank : 25)
Query Neighborhood Hits	187	Target Neighborhood Hits	296	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ITSN2_MOUSE
θ value	5.44631e-05 (rank : 31)	NC score	0.140900 (rank : 162)
Query Neighborhood Hits	187	Target Neighborhood Hits	1371	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LIN7A_HUMAN
θ value	9.29e-05 (rank : 32)	NC score	0.405854 (rank : 34)
Query Neighborhood Hits	187	Target Neighborhood Hits	193	Shared Neighborhood Hits	95
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	9.29e-05 (rank : 33)	NC score	0.405655 (rank : 35)
Query Neighborhood Hits	187	Target Neighborhood Hits	193	Shared Neighborhood Hits	95
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

CACB1_HUMAN
θ value	0.000121331 (rank : 34)	NC score	0.234718 (rank : 98)
Query Neighborhood Hits	187	Target Neighborhood Hits	44	Shared Neighborhood Hits	30
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

ZO2_HUMAN
θ value	0.000121331 (rank : 35)	NC score	0.437248 (rank : 26)
Query Neighborhood Hits	187	Target Neighborhood Hits	289	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ITSN2_HUMAN
θ value	0.000158464 (rank : 36)	NC score	0.143860 (rank : 161)
Query Neighborhood Hits	187	Target Neighborhood Hits	1173	Shared Neighborhood Hits	99
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CACB1_MOUSE
θ value	0.00020696 (rank : 37)	NC score	0.237543 (rank : 95)
Query Neighborhood Hits	187	Target Neighborhood Hits	46	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

MPDZ_HUMAN
θ value	0.000270298 (rank : 38)	NC score	0.352271 (rank : 42)
Query Neighborhood Hits	187	Target Neighborhood Hits	261	Shared Neighborhood Hits	97
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MAGI1_HUMAN
θ value	0.00035302 (rank : 39)	NC score	0.350567 (rank : 43)
Query Neighborhood Hits	187	Target Neighborhood Hits	388	Shared Neighborhood Hits	101
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	0.00035302 (rank : 40)	NC score	0.353827 (rank : 41)
Query Neighborhood Hits	187	Target Neighborhood Hits	403	Shared Neighborhood Hits	100
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

LIN7C_HUMAN
θ value	0.000461057 (rank : 41)	NC score	0.413270 (rank : 27)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	0.000461057 (rank : 42)	NC score	0.413270 (rank : 28)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	95
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

GRIP1_HUMAN
θ value	0.000602161 (rank : 43)	NC score	0.408789 (rank : 31)
Query Neighborhood Hits	187	Target Neighborhood Hits	231	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	0.000602161 (rank : 44)	NC score	0.407008 (rank : 33)
Query Neighborhood Hits	187	Target Neighborhood Hits	241	Shared Neighborhood Hits	96
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

LIN7B_MOUSE
θ value	0.000786445 (rank : 45)	NC score	0.410649 (rank : 30)
Query Neighborhood Hits	187	Target Neighborhood Hits	200	Shared Neighborhood Hits	96
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

MAGI2_HUMAN
θ value	0.000786445 (rank : 46)	NC score	0.323709 (rank : 56)
Query Neighborhood Hits	187	Target Neighborhood Hits	373	Shared Neighborhood Hits	100
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

APBA1_HUMAN
θ value	0.00102713 (rank : 47)	NC score	0.338225 (rank : 46)
Query Neighborhood Hits	187	Target Neighborhood Hits	325	Shared Neighborhood Hits	94
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

LIN7B_HUMAN
θ value	0.00102713 (rank : 48)	NC score	0.410731 (rank : 29)
Query Neighborhood Hits	187	Target Neighborhood Hits	200	Shared Neighborhood Hits	96
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MAGI2_MOUSE
θ value	0.00134147 (rank : 49)	NC score	0.331338 (rank : 51)
Query Neighborhood Hits	187	Target Neighborhood Hits	370	Shared Neighborhood Hits	101
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

LNX1_HUMAN
θ value	0.00228821 (rank : 50)	NC score	0.324144 (rank : 54)
Query Neighborhood Hits	187	Target Neighborhood Hits	379	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MPDZ_MOUSE
θ value	0.00228821 (rank : 51)	NC score	0.342634 (rank : 45)
Query Neighborhood Hits	187	Target Neighborhood Hits	298	Shared Neighborhood Hits	97
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

SRC_HUMAN
θ value	0.00228821 (rank : 52)	NC score	0.055080 (rank : 294)
Query Neighborhood Hits	187	Target Neighborhood Hits	1058	Shared Neighborhood Hits	95
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ZO1_HUMAN
θ value	0.00228821 (rank : 53)	NC score	0.403906 (rank : 36)
Query Neighborhood Hits	187	Target Neighborhood Hits	474	Shared Neighborhood Hits	93
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	0.00228821 (rank : 54)	NC score	0.408138 (rank : 32)
Query Neighborhood Hits	187	Target Neighborhood Hits	453	Shared Neighborhood Hits	92
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

CACB4_MOUSE
θ value	0.00390308 (rank : 55)	NC score	0.208012 (rank : 116)
Query Neighborhood Hits	187	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CRK_HUMAN
θ value	0.00390308 (rank : 56)	NC score	0.267810 (rank : 80)
Query Neighborhood Hits	187	Target Neighborhood Hits	308	Shared Neighborhood Hits	94
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.00390308 (rank : 57)	NC score	0.264982 (rank : 83)
Query Neighborhood Hits	187	Target Neighborhood Hits	314	Shared Neighborhood Hits	94
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

APBA3_HUMAN
θ value	0.00509761 (rank : 58)	NC score	0.319908 (rank : 58)
Query Neighborhood Hits	187	Target Neighborhood Hits	201	Shared Neighborhood Hits	87
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA3_MOUSE
θ value	0.00509761 (rank : 59)	NC score	0.305530 (rank : 69)
Query Neighborhood Hits	187	Target Neighborhood Hits	174	Shared Neighborhood Hits	87
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

CACB4_HUMAN
θ value	0.00509761 (rank : 60)	NC score	0.210735 (rank : 112)
Query Neighborhood Hits	187	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

GRAP_MOUSE
θ value	0.00665767 (rank : 61)	NC score	0.176823 (rank : 133)
Query Neighborhood Hits	187	Target Neighborhood Hits	309	Shared Neighborhood Hits	93
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRIP2_HUMAN
θ value	0.00665767 (rank : 62)	NC score	0.396864 (rank : 37)
Query Neighborhood Hits	187	Target Neighborhood Hits	256	Shared Neighborhood Hits	96
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

ARHG7_MOUSE
θ value	0.00869519 (rank : 63)	NC score	0.166537 (rank : 145)
Query Neighborhood Hits	187	Target Neighborhood Hits	396	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

INADL_HUMAN
θ value	0.0113563 (rank : 64)	NC score	0.360101 (rank : 39)
Query Neighborhood Hits	187	Target Neighborhood Hits	260	Shared Neighborhood Hits	97
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

NPHP1_HUMAN
θ value	0.0193708 (rank : 65)	NC score	0.147278 (rank : 157)
Query Neighborhood Hits	187	Target Neighborhood Hits	288	Shared Neighborhood Hits	74
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

YES_MOUSE
θ value	0.0193708 (rank : 66)	NC score	0.065008 (rank : 265)
Query Neighborhood Hits	187	Target Neighborhood Hits	1052	Shared Neighborhood Hits	93
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

APBA2_HUMAN
θ value	0.0252991 (rank : 67)	NC score	0.312243 (rank : 64)
Query Neighborhood Hits	187	Target Neighborhood Hits	220	Shared Neighborhood Hits	89
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.0252991 (rank : 68)	NC score	0.312848 (rank : 63)
Query Neighborhood Hits	187	Target Neighborhood Hits	219	Shared Neighborhood Hits	89
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

SNTG2_HUMAN
θ value	0.0252991 (rank : 69)	NC score	0.305840 (rank : 67)
Query Neighborhood Hits	187	Target Neighborhood Hits	191	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

STAM1_HUMAN
θ value	0.0252991 (rank : 70)	NC score	0.217415 (rank : 108)
Query Neighborhood Hits	187	Target Neighborhood Hits	271	Shared Neighborhood Hits	93
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

TXK_MOUSE
θ value	0.0252991 (rank : 71)	NC score	0.048621 (rank : 304)
Query Neighborhood Hits	187	Target Neighborhood Hits	980	Shared Neighborhood Hits	73
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CACB3_MOUSE
θ value	0.0330416 (rank : 72)	NC score	0.206453 (rank : 118)
Query Neighborhood Hits	187	Target Neighborhood Hits	48	Shared Neighborhood Hits	30
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

IL16_HUMAN
θ value	0.0330416 (rank : 73)	NC score	0.310233 (rank : 66)
Query Neighborhood Hits	187	Target Neighborhood Hits	207	Shared Neighborhood Hits	80
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LNX1_MOUSE
θ value	0.0330416 (rank : 74)	NC score	0.316092 (rank : 62)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	94
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

SH3K1_HUMAN
θ value	0.0330416 (rank : 75)	NC score	0.164089 (rank : 148)
Query Neighborhood Hits	187	Target Neighborhood Hits	341	Shared Neighborhood Hits	82
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CRKL_HUMAN
θ value	0.0431538 (rank : 76)	NC score	0.204235 (rank : 120)
Query Neighborhood Hits	187	Target Neighborhood Hits	313	Shared Neighborhood Hits	91
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GRB2_HUMAN
θ value	0.0431538 (rank : 77)	NC score	0.234648 (rank : 99)
Query Neighborhood Hits	187	Target Neighborhood Hits	310	Shared Neighborhood Hits	95
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.0431538 (rank : 78)	NC score	0.235475 (rank : 97)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	95
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

INADL_MOUSE
θ value	0.0431538 (rank : 79)	NC score	0.358435 (rank : 40)
Query Neighborhood Hits	187	Target Neighborhood Hits	290	Shared Neighborhood Hits	96
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

OSTF1_HUMAN
θ value	0.0431538 (rank : 80)	NC score	0.162452 (rank : 149)
Query Neighborhood Hits	187	Target Neighborhood Hits	466	Shared Neighborhood Hits	94
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

YES_HUMAN
θ value	0.0431538 (rank : 81)	NC score	0.062524 (rank : 275)
Query Neighborhood Hits	187	Target Neighborhood Hits	1059	Shared Neighborhood Hits	91
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CACB3_HUMAN
θ value	0.0563607 (rank : 82)	NC score	0.204899 (rank : 119)
Query Neighborhood Hits	187	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

NPHP1_MOUSE
θ value	0.0563607 (rank : 83)	NC score	0.210076 (rank : 114)
Query Neighborhood Hits	187	Target Neighborhood Hits	267	Shared Neighborhood Hits	90
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ARHG7_HUMAN
θ value	0.0736092 (rank : 84)	NC score	0.158467 (rank : 150)
Query Neighborhood Hits	187	Target Neighborhood Hits	347	Shared Neighborhood Hits	88
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CRKL_MOUSE
θ value	0.0736092 (rank : 85)	NC score	0.207795 (rank : 117)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

FYN_HUMAN
θ value	0.0736092 (rank : 86)	NC score	0.063771 (rank : 269)
Query Neighborhood Hits	187	Target Neighborhood Hits	1078	Shared Neighborhood Hits	89
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.0736092 (rank : 87)	NC score	0.064893 (rank : 266)
Query Neighborhood Hits	187	Target Neighborhood Hits	1073	Shared Neighborhood Hits	89
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

LNX2_HUMAN
θ value	0.0736092 (rank : 88)	NC score	0.294396 (rank : 75)
Query Neighborhood Hits	187	Target Neighborhood Hits	389	Shared Neighborhood Hits	94
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

STAM1_MOUSE
θ value	0.0736092 (rank : 89)	NC score	0.225244 (rank : 104)
Query Neighborhood Hits	187	Target Neighborhood Hits	273	Shared Neighborhood Hits	94
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PLCG1_MOUSE
θ value	0.0961366 (rank : 90)	NC score	0.090698 (rank : 211)
Query Neighborhood Hits	187	Target Neighborhood Hits	314	Shared Neighborhood Hits	72
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3K1_MOUSE
θ value	0.0961366 (rank : 91)	NC score	0.164462 (rank : 147)
Query Neighborhood Hits	187	Target Neighborhood Hits	332	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SNTG2_MOUSE
θ value	0.0961366 (rank : 92)	NC score	0.274263 (rank : 77)
Query Neighborhood Hits	187	Target Neighborhood Hits	176	Shared Neighborhood Hits	88
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

STAM2_MOUSE
θ value	0.0961366 (rank : 93)	NC score	0.208308 (rank : 115)
Query Neighborhood Hits	187	Target Neighborhood Hits	285	Shared Neighborhood Hits	90
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

FGR_HUMAN
θ value	0.125558 (rank : 94)	NC score	0.063157 (rank : 273)
Query Neighborhood Hits	187	Target Neighborhood Hits	1067	Shared Neighborhood Hits	93
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LNX2_MOUSE
θ value	0.125558 (rank : 95)	NC score	0.298118 (rank : 74)
Query Neighborhood Hits	187	Target Neighborhood Hits	407	Shared Neighborhood Hits	95
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

BTK_MOUSE
θ value	0.163984 (rank : 96)	NC score	0.041091 (rank : 308)
Query Neighborhood Hits	187	Target Neighborhood Hits	1017	Shared Neighborhood Hits	80
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CACB2_HUMAN
θ value	0.163984 (rank : 97)	NC score	0.174820 (rank : 135)
Query Neighborhood Hits	187	Target Neighborhood Hits	99	Shared Neighborhood Hits	27
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

GRAP_HUMAN
θ value	0.163984 (rank : 98)	NC score	0.170114 (rank : 143)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PPIP1_HUMAN
θ value	0.163984 (rank : 99)	NC score	0.098933 (rank : 198)
Query Neighborhood Hits	187	Target Neighborhood Hits	389	Shared Neighborhood Hits	86
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SRC_MOUSE
θ value	0.163984 (rank : 100)	NC score	0.035969 (rank : 311)
Query Neighborhood Hits	187	Target Neighborhood Hits	1033	Shared Neighborhood Hits	75
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP2_MOUSE
θ value	0.163984 (rank : 101)	NC score	0.077985 (rank : 236)
Query Neighborhood Hits	187	Target Neighborhood Hits	324	Shared Neighborhood Hits	75
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

TXK_HUMAN
θ value	0.163984 (rank : 102)	NC score	0.044361 (rank : 306)
Query Neighborhood Hits	187	Target Neighborhood Hits	971	Shared Neighborhood Hits	66
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ARHG6_HUMAN
θ value	0.21417 (rank : 103)	NC score	0.118714 (rank : 183)
Query Neighborhood Hits	187	Target Neighborhood Hits	376	Shared Neighborhood Hits	77
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FNBP2_HUMAN
θ value	0.21417 (rank : 104)	NC score	0.074559 (rank : 247)
Query Neighborhood Hits	187	Target Neighborhood Hits	432	Shared Neighborhood Hits	72
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

PDZD3_HUMAN
θ value	0.21417 (rank : 105)	NC score	0.265068 (rank : 82)
Query Neighborhood Hits	187	Target Neighborhood Hits	180	Shared Neighborhood Hits	90
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

IL16_MOUSE
θ value	0.279714 (rank : 106)	NC score	0.303181 (rank : 72)
Query Neighborhood Hits	187	Target Neighborhood Hits	189	Shared Neighborhood Hits	80
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PAR6A_HUMAN
θ value	0.279714 (rank : 107)	NC score	0.323948 (rank : 55)
Query Neighborhood Hits	187	Target Neighborhood Hits	119	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	0.279714 (rank : 108)	NC score	0.324627 (rank : 53)
Query Neighborhood Hits	187	Target Neighborhood Hits	115	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PARD3_MOUSE
θ value	0.279714 (rank : 109)	NC score	0.323521 (rank : 57)
Query Neighborhood Hits	187	Target Neighborhood Hits	290	Shared Neighborhood Hits	91
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDZD2_HUMAN
θ value	0.279714 (rank : 110)	NC score	0.319141 (rank : 60)
Query Neighborhood Hits	187	Target Neighborhood Hits	772	Shared Neighborhood Hits	97
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

RIMB1_MOUSE
θ value	0.279714 (rank : 111)	NC score	0.081880 (rank : 228)
Query Neighborhood Hits	187	Target Neighborhood Hits	1376	Shared Neighborhood Hits	86
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRGP1_HUMAN
θ value	0.279714 (rank : 112)	NC score	0.075447 (rank : 245)
Query Neighborhood Hits	187	Target Neighborhood Hits	390	Shared Neighborhood Hits	74
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ASPP2_HUMAN
θ value	0.365318 (rank : 113)	NC score	0.063142 (rank : 274)
Query Neighborhood Hits	187	Target Neighborhood Hits	1156	Shared Neighborhood Hits	81
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

CACB2_MOUSE
θ value	0.365318 (rank : 114)	NC score	0.168338 (rank : 144)
Query Neighborhood Hits	187	Target Neighborhood Hits	94	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CC27, Q8C5J5, Q9CTQ6	Gene names	Cacnb2, Cacnlb2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).

GOPC_HUMAN
θ value	0.365318 (rank : 115)	NC score	0.330205 (rank : 52)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	95
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.365318 (rank : 116)	NC score	0.334977 (rank : 48)
Query Neighborhood Hits	187	Target Neighborhood Hits	323	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

OSTF1_MOUSE
θ value	0.365318 (rank : 117)	NC score	0.139385 (rank : 164)
Query Neighborhood Hits	187	Target Neighborhood Hits	467	Shared Neighborhood Hits	93
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

RHG04_HUMAN
θ value	0.365318 (rank : 118)	NC score	0.093753 (rank : 204)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	83
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

STAM2_HUMAN
θ value	0.365318 (rank : 119)	NC score	0.184869 (rank : 126)
Query Neighborhood Hits	187	Target Neighborhood Hits	288	Shared Neighborhood Hits	92
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

UBE4A_HUMAN
θ value	0.365318 (rank : 120)	NC score	0.034639 (rank : 312)
Query Neighborhood Hits	187	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q14139, Q6P5T4, Q7Z639	Gene names	UBE4A, KIAA0126
Domain Architecture	No domain graphic available
Description	Ubiquitin conjugation factor E4 A.

BTK_HUMAN
θ value	0.47712 (rank : 121)	NC score	0.040963 (rank : 309)
Query Neighborhood Hits	187	Target Neighborhood Hits	1026	Shared Neighborhood Hits	79
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

GIPC1_MOUSE
θ value	0.47712 (rank : 122)	NC score	0.157789 (rank : 151)
Query Neighborhood Hits	187	Target Neighborhood Hits	92	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

RIMB2_HUMAN
θ value	0.47712 (rank : 123)	NC score	0.139392 (rank : 163)
Query Neighborhood Hits	187	Target Neighborhood Hits	263	Shared Neighborhood Hits	65
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SRGP2_HUMAN
θ value	0.47712 (rank : 124)	NC score	0.075587 (rank : 244)
Query Neighborhood Hits	187	Target Neighborhood Hits	331	Shared Neighborhood Hits	74
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

FGR_MOUSE
θ value	0.62314 (rank : 125)	NC score	0.055034 (rank : 295)
Query Neighborhood Hits	187	Target Neighborhood Hits	1069	Shared Neighborhood Hits	90
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

NOS1_HUMAN
θ value	0.62314 (rank : 126)	NC score	0.174588 (rank : 136)
Query Neighborhood Hits	187	Target Neighborhood Hits	218	Shared Neighborhood Hits	85
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PLCG1_HUMAN
θ value	0.62314 (rank : 127)	NC score	0.082608 (rank : 225)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	70
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RIMB1_HUMAN
θ value	0.62314 (rank : 128)	NC score	0.080495 (rank : 232)
Query Neighborhood Hits	187	Target Neighborhood Hits	1479	Shared Neighborhood Hits	84
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ARHG6_MOUSE
θ value	0.813845 (rank : 129)	NC score	0.116152 (rank : 185)
Query Neighborhood Hits	187	Target Neighborhood Hits	394	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

MX2_MOUSE
θ value	0.813845 (rank : 130)	NC score	0.016094 (rank : 316)
Query Neighborhood Hits	187	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WVP9, Q922L4	Gene names	Mx2
Domain Architecture	No domain graphic available
Description	Interferon-induced GTP-binding protein Mx2.

PAR6B_HUMAN
θ value	0.813845 (rank : 131)	NC score	0.331592 (rank : 50)
Query Neighborhood Hits	187	Target Neighborhood Hits	126	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	0.813845 (rank : 132)	NC score	0.333291 (rank : 49)
Query Neighborhood Hits	187	Target Neighborhood Hits	128	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

RHG12_HUMAN
θ value	0.813845 (rank : 133)	NC score	0.056592 (rank : 288)
Query Neighborhood Hits	187	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RIMB2_MOUSE
θ value	0.813845 (rank : 134)	NC score	0.135682 (rank : 167)
Query Neighborhood Hits	187	Target Neighborhood Hits	246	Shared Neighborhood Hits	63
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

FRK_HUMAN
θ value	1.06291 (rank : 135)	NC score	0.055427 (rank : 292)
Query Neighborhood Hits	187	Target Neighborhood Hits	1058	Shared Neighborhood Hits	89
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

GIPC1_HUMAN
θ value	1.06291 (rank : 136)	NC score	0.145515 (rank : 159)
Query Neighborhood Hits	187	Target Neighborhood Hits	91	Shared Neighborhood Hits	66
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

LAP4_HUMAN
θ value	1.06291 (rank : 137)	NC score	0.226054 (rank : 101)
Query Neighborhood Hits	187	Target Neighborhood Hits	608	Shared Neighborhood Hits	98
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
θ value	1.06291 (rank : 138)	NC score	0.225579 (rank : 103)
Query Neighborhood Hits	187	Target Neighborhood Hits	590	Shared Neighborhood Hits	98
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PAR6G_HUMAN
θ value	1.06291 (rank : 139)	NC score	0.304859 (rank : 70)
Query Neighborhood Hits	187	Target Neighborhood Hits	159	Shared Neighborhood Hits	84
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	1.06291 (rank : 140)	NC score	0.318712 (rank : 61)
Query Neighborhood Hits	187	Target Neighborhood Hits	121	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

SH3G2_HUMAN
θ value	1.06291 (rank : 141)	NC score	0.125649 (rank : 174)
Query Neighborhood Hits	187	Target Neighborhood Hits	324	Shared Neighborhood Hits	83
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

CD2AP_MOUSE
θ value	1.38821 (rank : 142)	NC score	0.146786 (rank : 158)
Query Neighborhood Hits	187	Target Neighborhood Hits	336	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PRLPE_MOUSE
θ value	1.38821 (rank : 143)	NC score	0.017530 (rank : 315)
Query Neighborhood Hits	187	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O54830, O35334, Q80X21	Gene names	Prlpe, Prlpg
Domain Architecture	No domain graphic available
Description	Placental prolactin-like protein E precursor (PRL-like protein E) (PLP-E) (Placental prolactin-like protein G) (PRL-like protein G) (PLP-G).

SNTG1_MOUSE
θ value	1.38821 (rank : 144)	NC score	0.252533 (rank : 88)
Query Neighborhood Hits	187	Target Neighborhood Hits	179	Shared Neighborhood Hits	85
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_HUMAN
θ value	1.81305 (rank : 145)	NC score	0.253901 (rank : 87)
Query Neighborhood Hits	187	Target Neighborhood Hits	181	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

PARD3_HUMAN
θ value	2.36792 (rank : 146)	NC score	0.310675 (rank : 65)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	94
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PDZD3_MOUSE
θ value	2.36792 (rank : 147)	NC score	0.225141 (rank : 105)
Query Neighborhood Hits	187	Target Neighborhood Hits	171	Shared Neighborhood Hits	85
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

RHG12_MOUSE
θ value	2.36792 (rank : 148)	NC score	0.047401 (rank : 305)
Query Neighborhood Hits	187	Target Neighborhood Hits	204	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SDCB2_MOUSE
θ value	2.36792 (rank : 149)	NC score	0.174507 (rank : 138)
Query Neighborhood Hits	187	Target Neighborhood Hits	118	Shared Neighborhood Hits	67
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SH3G1_HUMAN
θ value	2.36792 (rank : 150)	NC score	0.122881 (rank : 177)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	80
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_MOUSE
θ value	2.36792 (rank : 151)	NC score	0.126885 (rank : 171)
Query Neighborhood Hits	187	Target Neighborhood Hits	319	Shared Neighborhood Hits	80
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SNTA1_HUMAN
θ value	2.36792 (rank : 152)	NC score	0.245604 (rank : 91)
Query Neighborhood Hits	187	Target Neighborhood Hits	186	Shared Neighborhood Hits	87
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTB2_MOUSE
θ value	2.36792 (rank : 153)	NC score	0.269617 (rank : 78)
Query Neighborhood Hits	187	Target Neighborhood Hits	181	Shared Neighborhood Hits	91
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

NOS1_MOUSE
θ value	3.0926 (rank : 154)	NC score	0.153812 (rank : 152)
Query Neighborhood Hits	187	Target Neighborhood Hits	155	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PPIP1_MOUSE
θ value	3.0926 (rank : 155)	NC score	0.089652 (rank : 213)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	86
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PTK6_HUMAN
θ value	3.0926 (rank : 156)	NC score	0.041983 (rank : 307)
Query Neighborhood Hits	187	Target Neighborhood Hits	1020	Shared Neighborhood Hits	82
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SNTB2_HUMAN
θ value	3.0926 (rank : 157)	NC score	0.267240 (rank : 81)
Query Neighborhood Hits	187	Target Neighborhood Hits	180	Shared Neighborhood Hits	91
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

USH1C_MOUSE
θ value	3.0926 (rank : 158)	NC score	0.298694 (rank : 73)
Query Neighborhood Hits	187	Target Neighborhood Hits	557	Shared Neighborhood Hits	105
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

DDEF1_MOUSE
θ value	4.03905 (rank : 159)	NC score	0.062020 (rank : 278)
Query Neighborhood Hits	187	Target Neighborhood Hits	592	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

NEB2_HUMAN
θ value	4.03905 (rank : 160)	NC score	0.194098 (rank : 122)
Query Neighborhood Hits	187	Target Neighborhood Hits	883	Shared Neighborhood Hits	91
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	4.03905 (rank : 161)	NC score	0.191719 (rank : 123)
Query Neighborhood Hits	187	Target Neighborhood Hits	889	Shared Neighborhood Hits	91
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

SH3G3_MOUSE
θ value	4.03905 (rank : 162)	NC score	0.122402 (rank : 179)
Query Neighborhood Hits	187	Target Neighborhood Hits	236	Shared Neighborhood Hits	81
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VINEX_HUMAN
θ value	4.03905 (rank : 163)	NC score	0.103210 (rank : 192)
Query Neighborhood Hits	187	Target Neighborhood Hits	270	Shared Neighborhood Hits	76
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

3BP2_MOUSE
θ value	5.27518 (rank : 164)	NC score	0.008302 (rank : 319)
Query Neighborhood Hits	187	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CK5P2_HUMAN
θ value	5.27518 (rank : 165)	NC score	0.008043 (rank : 320)
Query Neighborhood Hits	187	Target Neighborhood Hits	1433	Shared Neighborhood Hits	29
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

PAR3L_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.319681 (rank : 59)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	96
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

SNTA1_MOUSE
θ value	5.27518 (rank : 167)	NC score	0.248849 (rank : 90)
Query Neighborhood Hits	187	Target Neighborhood Hits	170	Shared Neighborhood Hits	84
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SPN90_HUMAN
θ value	5.27518 (rank : 168)	NC score	0.081595 (rank : 230)
Query Neighborhood Hits	187	Target Neighborhood Hits	157	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SRBS1_HUMAN
θ value	5.27518 (rank : 169)	NC score	0.101620 (rank : 195)
Query Neighborhood Hits	187	Target Neighborhood Hits	396	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

USH1C_HUMAN
θ value	5.27518 (rank : 170)	NC score	0.303317 (rank : 71)
Query Neighborhood Hits	187	Target Neighborhood Hits	327	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

AHI1_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.068453 (rank : 254)
Query Neighborhood Hits	187	Target Neighborhood Hits	496	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CAR14_HUMAN
θ value	6.88961 (rank : 172)	NC score	0.081722 (rank : 229)
Query Neighborhood Hits	187	Target Neighborhood Hits	449	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CENPF_HUMAN
θ value	6.88961 (rank : 173)	NC score	0.009873 (rank : 317)
Query Neighborhood Hits	187	Target Neighborhood Hits	1932	Shared Neighborhood Hits	39
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

LIMK1_MOUSE
θ value	6.88961 (rank : 174)	NC score	0.033542 (rank : 313)
Query Neighborhood Hits	187	Target Neighborhood Hits	1008	Shared Neighborhood Hits	61
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

MY18A_HUMAN
θ value	6.88961 (rank : 175)	NC score	0.033284 (rank : 314)
Query Neighborhood Hits	187	Target Neighborhood Hits	1929	Shared Neighborhood Hits	100
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NCF1_MOUSE
θ value	6.88961 (rank : 176)	NC score	0.085771 (rank : 218)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	71
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PTN13_HUMAN
θ value	6.88961 (rank : 177)	NC score	0.181558 (rank : 130)
Query Neighborhood Hits	187	Target Neighborhood Hits	471	Shared Neighborhood Hits	98
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN13_MOUSE
θ value	6.88961 (rank : 178)	NC score	0.178778 (rank : 131)
Query Neighborhood Hits	187	Target Neighborhood Hits	426	Shared Neighborhood Hits	96
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

SDCB2_HUMAN
θ value	6.88961 (rank : 179)	NC score	0.183553 (rank : 129)
Query Neighborhood Hits	187	Target Neighborhood Hits	121	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SF3B2_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.009661 (rank : 318)
Query Neighborhood Hits	187	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

SRBS1_MOUSE
θ value	6.88961 (rank : 181)	NC score	0.102831 (rank : 194)
Query Neighborhood Hits	187	Target Neighborhood Hits	409	Shared Neighborhood Hits	83
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CD2AP_HUMAN
θ value	8.99809 (rank : 182)	NC score	0.131777 (rank : 170)
Query Neighborhood Hits	187	Target Neighborhood Hits	315	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

DDEF2_HUMAN
θ value	8.99809 (rank : 183)	NC score	0.040085 (rank : 310)
Query Neighborhood Hits	187	Target Neighborhood Hits	599	Shared Neighborhood Hits	60
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

NEB1_HUMAN
θ value	8.99809 (rank : 184)	NC score	0.215750 (rank : 109)
Query Neighborhood Hits	187	Target Neighborhood Hits	829	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

SH3G1_MOUSE
θ value	8.99809 (rank : 185)	NC score	0.122693 (rank : 178)
Query Neighborhood Hits	187	Target Neighborhood Hits	291	Shared Neighborhood Hits	82
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
θ value	8.99809 (rank : 186)	NC score	0.123666 (rank : 176)
Query Neighborhood Hits	187	Target Neighborhood Hits	222	Shared Neighborhood Hits	78
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SPN90_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.059650 (rank : 280)
Query Neighborhood Hits	187	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ABI1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.087879 (rank : 215)
Query Neighborhood Hits	187	Target Neighborhood Hits	257	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.093919 (rank : 203)
Query Neighborhood Hits	187	Target Neighborhood Hits	246	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.109354 (rank : 189)
Query Neighborhood Hits	187	Target Neighborhood Hits	350	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.108696 (rank : 190)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	81
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.057405 (rank : 283)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.056970 (rank : 287)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AFAD_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.183563 (rank : 128)
Query Neighborhood Hits	187	Target Neighborhood Hits	689	Shared Neighborhood Hits	87
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

AHI1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.075385 (rank : 246)
Query Neighborhood Hits	187	Target Neighborhood Hits	537	Shared Neighborhood Hits	79
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.056209 (rank : 290)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	68
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.056298 (rank : 289)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APXL_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.085789 (rank : 217)
Query Neighborhood Hits	187	Target Neighborhood Hits	553	Shared Neighborhood Hits	51
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARHG4_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.077572 (rank : 238)
Query Neighborhood Hits	187	Target Neighborhood Hits	242	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.067421 (rank : 259)
Query Neighborhood Hits	187	Target Neighborhood Hits	185	Shared Neighborhood Hits	60
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.068531 (rank : 252)
Query Neighborhood Hits	187	Target Neighborhood Hits	235	Shared Neighborhood Hits	74
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.068264 (rank : 255)
Query Neighborhood Hits	187	Target Neighborhood Hits	234	Shared Neighborhood Hits	73
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGB_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.116721 (rank : 184)
Query Neighborhood Hits	187	Target Neighborhood Hits	375	Shared Neighborhood Hits	80
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.120319 (rank : 182)
Query Neighborhood Hits	187	Target Neighborhood Hits	351	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.113697 (rank : 187)
Query Neighborhood Hits	187	Target Neighborhood Hits	344	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CAR11_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.086371 (rank : 216)
Query Neighborhood Hits	187	Target Neighborhood Hits	690	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CASL_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.050213 (rank : 302)
Query Neighborhood Hits	187	Target Neighborhood Hits	259	Shared Neighborhood Hits	64
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DBNL_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.053827 (rank : 298)
Query Neighborhood Hits	187	Target Neighborhood Hits	244	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.052876 (rank : 299)
Query Neighborhood Hits	187	Target Neighborhood Hits	306	Shared Neighborhood Hits	61
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DNMBP_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.074290 (rank : 248)
Query Neighborhood Hits	187	Target Neighborhood Hits	413	Shared Neighborhood Hits	78
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.071540 (rank : 249)
Query Neighborhood Hits	187	Target Neighborhood Hits	435	Shared Neighborhood Hits	77
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DVL1L_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.166207 (rank : 146)
Query Neighborhood Hits	187	Target Neighborhood Hits	146	Shared Neighborhood Hits	76
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.172196 (rank : 141)
Query Neighborhood Hits	187	Target Neighborhood Hits	158	Shared Neighborhood Hits	76
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.172195 (rank : 142)
Query Neighborhood Hits	187	Target Neighborhood Hits	146	Shared Neighborhood Hits	75
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL2_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.151458 (rank : 154)
Query Neighborhood Hits	187	Target Neighborhood Hits	223	Shared Neighborhood Hits	71
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.150078 (rank : 155)
Query Neighborhood Hits	187	Target Neighborhood Hits	233	Shared Neighborhood Hits	72
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.173850 (rank : 139)
Query Neighborhood Hits	187	Target Neighborhood Hits	194	Shared Neighborhood Hits	74
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.173696 (rank : 140)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	74
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

GIPC2_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.137491 (rank : 165)
Query Neighborhood Hits	187	Target Neighborhood Hits	93	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GIPC2_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.075709 (rank : 243)
Query Neighborhood Hits	187	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GIPC3_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.078320 (rank : 235)
Query Neighborhood Hits	187	Target Neighborhood Hits	52	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.076121 (rank : 241)
Query Neighborhood Hits	187	Target Neighborhood Hits	53	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

GRAP2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.124216 (rank : 175)
Query Neighborhood Hits	187	Target Neighborhood Hits	304	Shared Neighborhood Hits	88
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.121230 (rank : 181)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	85
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRASP_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.097840 (rank : 199)
Query Neighborhood Hits	187	Target Neighborhood Hits	147	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.095634 (rank : 200)
Query Neighborhood Hits	187	Target Neighborhood Hits	131	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

HCLS1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.066793 (rank : 261)
Query Neighborhood Hits	187	Target Neighborhood Hits	358	Shared Neighborhood Hits	68
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.067315 (rank : 260)
Query Neighborhood Hits	187	Target Neighborhood Hits	329	Shared Neighborhood Hits	68
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

K1849_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.178152 (rank : 132)
Query Neighborhood Hits	187	Target Neighborhood Hits	220	Shared Neighborhood Hits	81
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.185875 (rank : 125)
Query Neighborhood Hits	187	Target Neighborhood Hits	335	Shared Neighborhood Hits	84
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LAP2_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.083204 (rank : 224)
Query Neighborhood Hits	187	Target Neighborhood Hits	499	Shared Neighborhood Hits	58
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.079890 (rank : 234)
Query Neighborhood Hits	187	Target Neighborhood Hits	482	Shared Neighborhood Hits	59
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LASP1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.050155 (rank : 303)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	60
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LMO7_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.057954 (rank : 282)
Query Neighborhood Hits	187	Target Neighborhood Hits	507	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LRRC7_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.084002 (rank : 221)
Query Neighborhood Hits	187	Target Neighborhood Hits	423	Shared Neighborhood Hits	61
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.083801 (rank : 222)
Query Neighborhood Hits	187	Target Neighborhood Hits	416	Shared Neighborhood Hits	61
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

NCF1_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.093303 (rank : 206)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	71
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF2_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.121713 (rank : 180)
Query Neighborhood Hits	187	Target Neighborhood Hits	229	Shared Neighborhood Hits	75
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.062203 (rank : 277)
Query Neighborhood Hits	187	Target Neighborhood Hits	161	Shared Neighborhood Hits	55
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.070851 (rank : 251)
Query Neighborhood Hits	187	Target Neighborhood Hits	177	Shared Neighborhood Hits	63
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.126342 (rank : 173)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	85
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.093677 (rank : 205)
Query Neighborhood Hits	187	Target Neighborhood Hits	310	Shared Neighborhood Hits	74
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NHERF_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.200607 (rank : 121)
Query Neighborhood Hits	187	Target Neighborhood Hits	190	Shared Neighborhood Hits	79
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.210167 (rank : 113)
Query Neighborhood Hits	187	Target Neighborhood Hits	195	Shared Neighborhood Hits	81
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.217530 (rank : 107)
Query Neighborhood Hits	187	Target Neighborhood Hits	197	Shared Neighborhood Hits	87
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.225623 (rank : 102)
Query Neighborhood Hits	187	Target Neighborhood Hits	194	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NOXO1_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.057315 (rank : 284)
Query Neighborhood Hits	187	Target Neighborhood Hits	114	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PACN1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.091296 (rank : 209)
Query Neighborhood Hits	187	Target Neighborhood Hits	320	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.085022 (rank : 219)
Query Neighborhood Hits	187	Target Neighborhood Hits	283	Shared Neighborhood Hits	79
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.077525 (rank : 239)
Query Neighborhood Hits	187	Target Neighborhood Hits	339	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.084073 (rank : 220)
Query Neighborhood Hits	187	Target Neighborhood Hits	382	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.062216 (rank : 276)
Query Neighborhood Hits	187	Target Neighborhood Hits	385	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.064259 (rank : 267)
Query Neighborhood Hits	187	Target Neighborhood Hits	380	Shared Neighborhood Hits	78
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PCLO_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.100945 (rank : 196)
Query Neighborhood Hits	187	Target Neighborhood Hits	2275	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDLI1_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.052500 (rank : 301)
Query Neighborhood Hits	187	Target Neighborhood Hits	213	Shared Neighborhood Hits	50
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI2_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.126378 (rank : 172)
Query Neighborhood Hits	187	Target Neighborhood Hits	245	Shared Neighborhood Hits	60
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI2_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.094897 (rank : 201)
Query Neighborhood Hits	187	Target Neighborhood Hits	220	Shared Neighborhood Hits	59
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDLI3_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.081527 (rank : 231)
Query Neighborhood Hits	187	Target Neighborhood Hits	199	Shared Neighborhood Hits	58
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.066080 (rank : 264)
Query Neighborhood Hits	187	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.061133 (rank : 279)
Query Neighborhood Hits	187	Target Neighborhood Hits	245	Shared Neighborhood Hits	52
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.068469 (rank : 253)
Query Neighborhood Hits	187	Target Neighborhood Hits	233	Shared Neighborhood Hits	56
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDZ11_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.231887 (rank : 100)
Query Neighborhood Hits	187	Target Neighborhood Hits	160	Shared Neighborhood Hits	72
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.236765 (rank : 96)
Query Neighborhood Hits	187	Target Neighborhood Hits	154	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.261551 (rank : 85)
Query Neighborhood Hits	187	Target Neighborhood Hits	190	Shared Neighborhood Hits	82
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.269002 (rank : 79)
Query Neighborhood Hits	187	Target Neighborhood Hits	191	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD6_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.094440 (rank : 202)
Query Neighborhood Hits	187	Target Neighborhood Hits	81	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PDZD7_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.288614 (rank : 76)
Query Neighborhood Hits	187	Target Neighborhood Hits	181	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PDZD8_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.055484 (rank : 291)
Query Neighborhood Hits	187	Target Neighborhood Hits	185	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PDZK4_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.144201 (rank : 160)
Query Neighborhood Hits	187	Target Neighborhood Hits	165	Shared Neighborhood Hits	72
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.134120 (rank : 169)
Query Neighborhood Hits	187	Target Neighborhood Hits	165	Shared Neighborhood Hits	71
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PEX13_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.054675 (rank : 297)
Query Neighborhood Hits	187	Target Neighborhood Hits	126	Shared Neighborhood Hits	48
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PICK1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.174570 (rank : 137)
Query Neighborhood Hits	187	Target Neighborhood Hits	132	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.176785 (rank : 134)
Query Neighborhood Hits	187	Target Neighborhood Hits	131	Shared Neighborhood Hits	77
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PLCG2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.070945 (rank : 250)
Query Neighborhood Hits	187	Target Neighborhood Hits	280	Shared Neighborhood Hits	69
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PRAX_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.057137 (rank : 285)
Query Neighborhood Hits	187	Target Neighborhood Hits	199	Shared Neighborhood Hits	27
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

PSCBP_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.077798 (rank : 237)
Query Neighborhood Hits	187	Target Neighborhood Hits	123	Shared Neighborhood Hits	56
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PSCBP_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.082329 (rank : 226)
Query Neighborhood Hits	187	Target Neighborhood Hits	118	Shared Neighborhood Hits	54
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PZRN3_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.212082 (rank : 110)
Query Neighborhood Hits	187	Target Neighborhood Hits	461	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.210785 (rank : 111)
Query Neighborhood Hits	187	Target Neighborhood Hits	447	Shared Neighborhood Hits	85
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN4_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.220895 (rank : 106)
Query Neighborhood Hits	187	Target Neighborhood Hits	438	Shared Neighborhood Hits	87
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RGS12_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.110247 (rank : 188)
Query Neighborhood Hits	187	Target Neighborhood Hits	333	Shared Neighborhood Hits	65
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RHPN1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.100133 (rank : 197)
Query Neighborhood Hits	187	Target Neighborhood Hits	158	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.115810 (rank : 186)
Query Neighborhood Hits	187	Target Neighborhood Hits	154	Shared Neighborhood Hits	64
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RIMS1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.093024 (rank : 207)
Query Neighborhood Hits	187	Target Neighborhood Hits	437	Shared Neighborhood Hits	83
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.076418 (rank : 240)
Query Neighborhood Hits	187	Target Neighborhood Hits	342	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.075883 (rank : 242)
Query Neighborhood Hits	187	Target Neighborhood Hits	376	Shared Neighborhood Hits	76
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RPGF2_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.090299 (rank : 212)
Query Neighborhood Hits	187	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.106252 (rank : 191)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RUSC1_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.057984 (rank : 281)
Query Neighborhood Hits	187	Target Neighborhood Hits	226	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SDCB1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.189271 (rank : 124)
Query Neighborhood Hits	187	Target Neighborhood Hits	150	Shared Neighborhood Hits	79
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.184099 (rank : 127)
Query Neighborhood Hits	187	Target Neighborhood Hits	144	Shared Neighborhood Hits	71
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SHAN1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.081883 (rank : 227)
Query Neighborhood Hits	187	Target Neighborhood Hits	1041	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.083651 (rank : 223)
Query Neighborhood Hits	187	Target Neighborhood Hits	346	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.102951 (rank : 193)
Query Neighborhood Hits	187	Target Neighborhood Hits	446	Shared Neighborhood Hits	113
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLAP2_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.052512 (rank : 300)
Query Neighborhood Hits	187	Target Neighborhood Hits	139	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.054747 (rank : 296)
Query Neighborhood Hits	187	Target Neighborhood Hits	136	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SNTB1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.251843 (rank : 89)
Query Neighborhood Hits	187	Target Neighborhood Hits	157	Shared Neighborhood Hits	83
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.244231 (rank : 94)
Query Neighborhood Hits	187	Target Neighborhood Hits	160	Shared Neighborhood Hits	81
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SRC8_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.063308 (rank : 272)
Query Neighborhood Hits	187	Target Neighborhood Hits	269	Shared Neighborhood Hits	70
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.063986 (rank : 268)
Query Neighborhood Hits	187	Target Neighborhood Hits	292	Shared Neighborhood Hits	71
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.067567 (rank : 258)
Query Neighborhood Hits	187	Target Neighborhood Hits	228	Shared Neighborhood Hits	66
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.067891 (rank : 257)
Query Neighborhood Hits	187	Target Neighborhood Hits	232	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.090807 (rank : 210)
Query Neighborhood Hits	187	Target Neighborhood Hits	276	Shared Neighborhood Hits	82
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.092087 (rank : 208)
Query Neighborhood Hits	187	Target Neighborhood Hits	268	Shared Neighborhood Hits	80
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STXB4_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.151979 (rank : 153)
Query Neighborhood Hits	187	Target Neighborhood Hits	616	Shared Neighborhood Hits	74
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.148288 (rank : 156)
Query Neighborhood Hits	187	Target Neighborhood Hits	629	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.305586 (rank : 68)
Query Neighborhood Hits	187	Target Neighborhood Hits	162	Shared Neighborhood Hits	78
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

SYNP2_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.063551 (rank : 270)
Query Neighborhood Hits	187	Target Neighborhood Hits	252	Shared Neighborhood Hits	56
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SYP2L_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.079940 (rank : 233)
Query Neighborhood Hits	187	Target Neighborhood Hits	400	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TX1B3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.245068 (rank : 92)
Query Neighborhood Hits	187	Target Neighborhood Hits	161	Shared Neighborhood Hits	80
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.244606 (rank : 93)
Query Neighborhood Hits	187	Target Neighborhood Hits	158	Shared Neighborhood Hits	78
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

VAV2_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.066656 (rank : 262)
Query Neighborhood Hits	187	Target Neighborhood Hits	453	Shared Neighborhood Hits	71
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.068136 (rank : 256)
Query Neighborhood Hits	187	Target Neighborhood Hits	456	Shared Neighborhood Hits	70
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.057090 (rank : 286)
Query Neighborhood Hits	187	Target Neighborhood Hits	398	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.055380 (rank : 293)
Query Neighborhood Hits	187	Target Neighborhood Hits	404	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.063470 (rank : 271)
Query Neighborhood Hits	187	Target Neighborhood Hits	452	Shared Neighborhood Hits	71
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.066088 (rank : 263)
Query Neighborhood Hits	187	Target Neighborhood Hits	430	Shared Neighborhood Hits	75
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VINEX_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.088996 (rank : 214)
Query Neighborhood Hits	187	Target Neighborhood Hits	286	Shared Neighborhood Hits	75
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WHRN_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.264626 (rank : 84)
Query Neighborhood Hits	187	Target Neighborhood Hits	325	Shared Neighborhood Hits	92
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.254038 (rank : 86)
Query Neighborhood Hits	187	Target Neighborhood Hits	412	Shared Neighborhood Hits	90
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

Hits sorted by NC score

MPP6_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	187	Target Neighborhood Hits	187	Shared Neighborhood Hits	187
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MPP6_HUMAN
NC score	0.998580 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	187	Target Neighborhood Hits	180	Shared Neighborhood Hits	179
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP2_HUMAN
NC score	0.983789 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	187	Target Neighborhood Hits	173	Shared Neighborhood Hits	143
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
NC score	0.983279 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	187	Target Neighborhood Hits	189	Shared Neighborhood Hits	148
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

EM55_HUMAN
NC score	0.957079 (rank : 5)	θ value	7.91507e-97 (rank : 7)
Query Neighborhood Hits	187	Target Neighborhood Hits	228	Shared Neighborhood Hits	157
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
NC score	0.955400 (rank : 6)	θ value	4.80189e-94 (rank : 10)
Query Neighborhood Hits	187	Target Neighborhood Hits	221	Shared Neighborhood Hits	154
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MPP5_MOUSE
NC score	0.940942 (rank : 7)	θ value	5.67233e-95 (rank : 9)
Query Neighborhood Hits	187	Target Neighborhood Hits	226	Shared Neighborhood Hits	150
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP5_HUMAN
NC score	0.940702 (rank : 8)	θ value	1.94955e-95 (rank : 8)
Query Neighborhood Hits	187	Target Neighborhood Hits	231	Shared Neighborhood Hits	150
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP3_HUMAN
NC score	0.929639 (rank : 9)	θ value	7.95186e-81 (rank : 11)
Query Neighborhood Hits	187	Target Neighborhood Hits	171	Shared Neighborhood Hits	122
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
NC score	0.922629 (rank : 10)	θ value	1.83746e-69 (rank : 12)
Query Neighborhood Hits	187	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP4_MOUSE
NC score	0.889907 (rank : 11)	θ value	1.28434e-38 (rank : 19)
Query Neighborhood Hits	187	Target Neighborhood Hits	188	Shared Neighborhood Hits	128
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

KGUA_MOUSE
NC score	0.872910 (rank : 12)	θ value	2.12685e-25 (rank : 23)
Query Neighborhood Hits	187	Target Neighborhood Hits	45	Shared Neighborhood Hits	32
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_HUMAN
NC score	0.868453 (rank : 13)	θ value	1.99067e-23 (rank : 24)
Query Neighborhood Hits	187	Target Neighborhood Hits	41	Shared Neighborhood Hits	30
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

MPP4_HUMAN
NC score	0.865610 (rank : 14)	θ value	2.42216e-37 (rank : 22)
Query Neighborhood Hits	187	Target Neighborhood Hits	205	Shared Neighborhood Hits	131
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

DLG3_HUMAN
NC score	0.750487 (rank : 15)	θ value	3.26607e-42 (rank : 14)
Query Neighborhood Hits	187	Target Neighborhood Hits	269	Shared Neighborhood Hits	143
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG2_HUMAN
NC score	0.749079 (rank : 16)	θ value	6.58091e-43 (rank : 13)
Query Neighborhood Hits	187	Target Neighborhood Hits	279	Shared Neighborhood Hits	148
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
NC score	0.748272 (rank : 17)	θ value	2.76489e-41 (rank : 15)
Query Neighborhood Hits	187	Target Neighborhood Hits	271	Shared Neighborhood Hits	148
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_MOUSE
NC score	0.746950 (rank : 18)	θ value	6.15952e-41 (rank : 16)
Query Neighborhood Hits	187	Target Neighborhood Hits	274	Shared Neighborhood Hits	143
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG1_MOUSE
NC score	0.739334 (rank : 19)	θ value	3.99248e-40 (rank : 17)
Query Neighborhood Hits	187	Target Neighborhood Hits	285	Shared Neighborhood Hits	137
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG1_HUMAN
NC score	0.738073 (rank : 20)	θ value	5.21438e-40 (rank : 18)
Query Neighborhood Hits	187	Target Neighborhood Hits	290	Shared Neighborhood Hits	135
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG4_HUMAN
NC score	0.726710 (rank : 21)	θ value	3.73686e-38 (rank : 20)
Query Neighborhood Hits	187	Target Neighborhood Hits	286	Shared Neighborhood Hits	133
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
NC score	0.725963 (rank : 22)	θ value	3.73686e-38 (rank : 21)
Query Neighborhood Hits	187	Target Neighborhood Hits	282	Shared Neighborhood Hits	133
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

ZO3_HUMAN
NC score	0.469015 (rank : 23)	θ value	1.29631e-06 (rank : 26)
Query Neighborhood Hits	187	Target Neighborhood Hits	219	Shared Neighborhood Hits	90
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
NC score	0.463026 (rank : 24)	θ value	7.59969e-07 (rank : 25)
Query Neighborhood Hits	187	Target Neighborhood Hits	224	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO2_MOUSE
NC score	0.442953 (rank : 25)	θ value	1.09739e-05 (rank : 30)
Query Neighborhood Hits	187	Target Neighborhood Hits	296	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_HUMAN
NC score	0.437248 (rank : 26)	θ value	0.000121331 (rank : 35)
Query Neighborhood Hits	187	Target Neighborhood Hits	289	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

LIN7C_HUMAN
NC score	0.413270 (rank : 27)	θ value	0.000461057 (rank : 41)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.413270 (rank : 28)	θ value	0.000461057 (rank : 42)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	95
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7B_HUMAN
NC score	0.410731 (rank : 29)	θ value	0.00102713 (rank : 48)
Query Neighborhood Hits	187	Target Neighborhood Hits	200	Shared Neighborhood Hits	96
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
NC score	0.410649 (rank : 30)	θ value	0.000786445 (rank : 45)
Query Neighborhood Hits	187	Target Neighborhood Hits	200	Shared Neighborhood Hits	96
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

GRIP1_HUMAN
NC score	0.408789 (rank : 31)	θ value	0.000602161 (rank : 43)
Query Neighborhood Hits	187	Target Neighborhood Hits	231	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

ZO1_MOUSE
NC score	0.408138 (rank : 32)	θ value	0.00228821 (rank : 54)
Query Neighborhood Hits	187	Target Neighborhood Hits	453	Shared Neighborhood Hits	92
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

GRIP1_MOUSE
NC score	0.407008 (rank : 33)	θ value	0.000602161 (rank : 44)
Query Neighborhood Hits	187	Target Neighborhood Hits	241	Shared Neighborhood Hits	96
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

LIN7A_HUMAN
NC score	0.405854 (rank : 34)	θ value	9.29e-05 (rank : 32)
Query Neighborhood Hits	187	Target Neighborhood Hits	193	Shared Neighborhood Hits	95
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
NC score	0.405655 (rank : 35)	θ value	9.29e-05 (rank : 33)
Query Neighborhood Hits	187	Target Neighborhood Hits	193	Shared Neighborhood Hits	95
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

ZO1_HUMAN
NC score	0.403906 (rank : 36)	θ value	0.00228821 (rank : 53)
Query Neighborhood Hits	187	Target Neighborhood Hits	474	Shared Neighborhood Hits	93
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

GRIP2_HUMAN
NC score	0.396864 (rank : 37)	θ value	0.00665767 (rank : 62)
Query Neighborhood Hits	187	Target Neighborhood Hits	256	Shared Neighborhood Hits	96
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

DLG5_HUMAN
NC score	0.379869 (rank : 38)	θ value	6.43352e-06 (rank : 28)
Query Neighborhood Hits	187	Target Neighborhood Hits	1088	Shared Neighborhood Hits	126
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

INADL_HUMAN
NC score	0.360101 (rank : 39)	θ value	0.0113563 (rank : 64)
Query Neighborhood Hits	187	Target Neighborhood Hits	260	Shared Neighborhood Hits	97
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
NC score	0.358435 (rank : 40)	θ value	0.0431538 (rank : 79)
Query Neighborhood Hits	187	Target Neighborhood Hits	290	Shared Neighborhood Hits	96
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MAGI1_MOUSE
NC score	0.353827 (rank : 41)	θ value	0.00035302 (rank : 40)
Query Neighborhood Hits	187	Target Neighborhood Hits	403	Shared Neighborhood Hits	100
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MPDZ_HUMAN
NC score	0.352271 (rank : 42)	θ value	0.000270298 (rank : 38)
Query Neighborhood Hits	187	Target Neighborhood Hits	261	Shared Neighborhood Hits	97
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MAGI1_HUMAN
NC score	0.350567 (rank : 43)	θ value	0.00035302 (rank : 39)
Query Neighborhood Hits	187	Target Neighborhood Hits	388	Shared Neighborhood Hits	101
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

CSKP_HUMAN
NC score	0.344022 (rank : 44)	θ value	7.12574e-114 (rank : 5)
Query Neighborhood Hits	187	Target Neighborhood Hits	1022	Shared Neighborhood Hits	160
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

MPDZ_MOUSE
NC score	0.342634 (rank : 45)	θ value	0.00228821 (rank : 51)
Query Neighborhood Hits	187	Target Neighborhood Hits	298	Shared Neighborhood Hits	97
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

APBA1_HUMAN
NC score	0.338225 (rank : 46)	θ value	0.00102713 (rank : 47)
Query Neighborhood Hits	187	Target Neighborhood Hits	325	Shared Neighborhood Hits	94
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

CSKP_MOUSE
NC score	0.335615 (rank : 47)	θ value	8.43692e-107 (rank : 6)
Query Neighborhood Hits	187	Target Neighborhood Hits	1027	Shared Neighborhood Hits	159
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

GOPC_MOUSE
NC score	0.334977 (rank : 48)	θ value	0.365318 (rank : 116)
Query Neighborhood Hits	187	Target Neighborhood Hits	323	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

PAR6B_MOUSE
NC score	0.333291 (rank : 49)	θ value	0.813845 (rank : 132)
Query Neighborhood Hits	187	Target Neighborhood Hits	128	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_HUMAN
NC score	0.331592 (rank : 50)	θ value	0.813845 (rank : 131)
Query Neighborhood Hits	187	Target Neighborhood Hits	126	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

MAGI2_MOUSE
NC score	0.331338 (rank : 51)	θ value	0.00134147 (rank : 49)
Query Neighborhood Hits	187	Target Neighborhood Hits	370	Shared Neighborhood Hits	101
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

GOPC_HUMAN
NC score	0.330205 (rank : 52)	θ value	0.365318 (rank : 115)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	95
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

PAR6A_MOUSE
NC score	0.324627 (rank : 53)	θ value	0.279714 (rank : 108)
Query Neighborhood Hits	187	Target Neighborhood Hits	115	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

LNX1_HUMAN
NC score	0.324144 (rank : 54)	θ value	0.00228821 (rank : 50)
Query Neighborhood Hits	187	Target Neighborhood Hits	379	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

PAR6A_HUMAN
NC score	0.323948 (rank : 55)	θ value	0.279714 (rank : 107)
Query Neighborhood Hits	187	Target Neighborhood Hits	119	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

MAGI2_HUMAN
NC score	0.323709 (rank : 56)	θ value	0.000786445 (rank : 46)
Query Neighborhood Hits	187	Target Neighborhood Hits	373	Shared Neighborhood Hits	100
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

PARD3_MOUSE
NC score	0.323521 (rank : 57)	θ value	0.279714 (rank : 109)
Query Neighborhood Hits	187	Target Neighborhood Hits	290	Shared Neighborhood Hits	91
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

APBA3_HUMAN
NC score	0.319908 (rank : 58)	θ value	0.00509761 (rank : 58)
Query Neighborhood Hits	187	Target Neighborhood Hits	201	Shared Neighborhood Hits	87
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PAR3L_HUMAN
NC score	0.319681 (rank : 59)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	96
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PDZD2_HUMAN
NC score	0.319141 (rank : 60)	θ value	0.279714 (rank : 110)
Query Neighborhood Hits	187	Target Neighborhood Hits	772	Shared Neighborhood Hits	97
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PAR6G_MOUSE
NC score	0.318712 (rank : 61)	θ value	1.06291 (rank : 140)
Query Neighborhood Hits	187	Target Neighborhood Hits	121	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

LNX1_MOUSE
NC score	0.316092 (rank : 62)	θ value	0.0330416 (rank : 74)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	94
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

APBA2_MOUSE
NC score	0.312848 (rank : 63)	θ value	0.0252991 (rank : 68)
Query Neighborhood Hits	187	Target Neighborhood Hits	219	Shared Neighborhood Hits	89
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.312243 (rank : 64)	θ value	0.0252991 (rank : 67)
Query Neighborhood Hits	187	Target Neighborhood Hits	220	Shared Neighborhood Hits	89
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

PARD3_HUMAN
NC score	0.310675 (rank : 65)	θ value	2.36792 (rank : 146)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	94
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

IL16_HUMAN
NC score	0.310233 (rank : 66)	θ value	0.0330416 (rank : 73)
Query Neighborhood Hits	187	Target Neighborhood Hits	207	Shared Neighborhood Hits	80
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

SNTG2_HUMAN
NC score	0.305840 (rank : 67)	θ value	0.0252991 (rank : 69)
Query Neighborhood Hits	187	Target Neighborhood Hits	191	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SYJ2B_HUMAN
NC score	0.305586 (rank : 68)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	187	Target Neighborhood Hits	162	Shared Neighborhood Hits	78
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

APBA3_MOUSE
NC score	0.305530 (rank : 69)	θ value	0.00509761 (rank : 59)
Query Neighborhood Hits	187	Target Neighborhood Hits	174	Shared Neighborhood Hits	87
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PAR6G_HUMAN
NC score	0.304859 (rank : 70)	θ value	1.06291 (rank : 139)
Query Neighborhood Hits	187	Target Neighborhood Hits	159	Shared Neighborhood Hits	84
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

USH1C_HUMAN
NC score	0.303317 (rank : 71)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	187	Target Neighborhood Hits	327	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

IL16_MOUSE
NC score	0.303181 (rank : 72)	θ value	0.279714 (rank : 106)
Query Neighborhood Hits	187	Target Neighborhood Hits	189	Shared Neighborhood Hits	80
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

USH1C_MOUSE
NC score	0.298694 (rank : 73)	θ value	3.0926 (rank : 158)
Query Neighborhood Hits	187	Target Neighborhood Hits	557	Shared Neighborhood Hits	105
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

LNX2_MOUSE
NC score	0.298118 (rank : 74)	θ value	0.125558 (rank : 95)
Query Neighborhood Hits	187	Target Neighborhood Hits	407	Shared Neighborhood Hits	95
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LNX2_HUMAN
NC score	0.294396 (rank : 75)	θ value	0.0736092 (rank : 88)
Query Neighborhood Hits	187	Target Neighborhood Hits	389	Shared Neighborhood Hits	94
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

PDZD7_HUMAN
NC score	0.288614 (rank : 76)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	187	Target Neighborhood Hits	181	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

SNTG2_MOUSE
NC score	0.274263 (rank : 77)	θ value	0.0961366 (rank : 92)
Query Neighborhood Hits	187	Target Neighborhood Hits	176	Shared Neighborhood Hits	88
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTB2_MOUSE
NC score	0.269617 (rank : 78)	θ value	2.36792 (rank : 153)
Query Neighborhood Hits	187	Target Neighborhood Hits	181	Shared Neighborhood Hits	91
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

PDZD1_MOUSE
NC score	0.269002 (rank : 79)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	187	Target Neighborhood Hits	191	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

CRK_HUMAN
NC score	0.267810 (rank : 80)	θ value	0.00390308 (rank : 56)
Query Neighborhood Hits	187	Target Neighborhood Hits	308	Shared Neighborhood Hits	94
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SNTB2_HUMAN
NC score	0.267240 (rank : 81)	θ value	3.0926 (rank : 157)
Query Neighborhood Hits	187	Target Neighborhood Hits	180	Shared Neighborhood Hits	91
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

PDZD3_HUMAN
NC score	0.265068 (rank : 82)	θ value	0.21417 (rank : 105)
Query Neighborhood Hits	187	Target Neighborhood Hits	180	Shared Neighborhood Hits	90
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

CRK_MOUSE
NC score	0.264982 (rank : 83)	θ value	0.00390308 (rank : 57)
Query Neighborhood Hits	187	Target Neighborhood Hits	314	Shared Neighborhood Hits	94
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

WHRN_HUMAN
NC score	0.264626 (rank : 84)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	187	Target Neighborhood Hits	325	Shared Neighborhood Hits	92
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

PDZD1_HUMAN
NC score	0.261551 (rank : 85)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	187	Target Neighborhood Hits	190	Shared Neighborhood Hits	82
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

WHRN_MOUSE
NC score	0.254038 (rank : 86)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	187	Target Neighborhood Hits	412	Shared Neighborhood Hits	90
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

SNTG1_HUMAN
NC score	0.253901 (rank : 87)	θ value	1.81305 (rank : 145)
Query Neighborhood Hits	187	Target Neighborhood Hits	181	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
NC score	0.252533 (rank : 88)	θ value	1.38821 (rank : 144)
Query Neighborhood Hits	187	Target Neighborhood Hits	179	Shared Neighborhood Hits	85
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTB1_HUMAN
NC score	0.251843 (rank : 89)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	187	Target Neighborhood Hits	157	Shared Neighborhood Hits	83
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTA1_MOUSE
NC score	0.248849 (rank : 90)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	187	Target Neighborhood Hits	170	Shared Neighborhood Hits	84
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTA1_HUMAN
NC score	0.245604 (rank : 91)	θ value	2.36792 (rank : 152)
Query Neighborhood Hits	187	Target Neighborhood Hits	186	Shared Neighborhood Hits	87
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

TX1B3_HUMAN
NC score	0.245068 (rank : 92)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	187	Target Neighborhood Hits	161	Shared Neighborhood Hits	80
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.244606 (rank : 93)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	187	Target Neighborhood Hits	158	Shared Neighborhood Hits	78
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

SNTB1_MOUSE
NC score	0.244231 (rank : 94)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	187	Target Neighborhood Hits	160	Shared Neighborhood Hits	81
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

CACB1_MOUSE
NC score	0.237543 (rank : 95)	θ value	0.00020696 (rank : 37)
Query Neighborhood Hits	187	Target Neighborhood Hits	46	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

PDZ11_MOUSE
NC score	0.236765 (rank : 96)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	187	Target Neighborhood Hits	154	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

GRB2_MOUSE
NC score	0.235475 (rank : 97)	θ value	0.0431538 (rank : 78)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	95
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

CACB1_HUMAN
NC score	0.234718 (rank : 98)	θ value	0.000121331 (rank : 34)
Query Neighborhood Hits	187	Target Neighborhood Hits	44	Shared Neighborhood Hits	30
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

GRB2_HUMAN
NC score	0.234648 (rank : 99)	θ value	0.0431538 (rank : 77)
Query Neighborhood Hits	187	Target Neighborhood Hits	310	Shared Neighborhood Hits	95
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

PDZ11_HUMAN
NC score	0.231887 (rank : 100)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	187	Target Neighborhood Hits	160	Shared Neighborhood Hits	72
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

LAP4_HUMAN
NC score	0.226054 (rank : 101)	θ value	1.06291 (rank : 137)
Query Neighborhood Hits	187	Target Neighborhood Hits	608	Shared Neighborhood Hits	98
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

NHRF2_MOUSE
NC score	0.225623 (rank : 102)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	187	Target Neighborhood Hits	194	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

LAP4_MOUSE
NC score	0.225579 (rank : 103)	θ value	1.06291 (rank : 138)
Query Neighborhood Hits	187	Target Neighborhood Hits	590	Shared Neighborhood Hits	98
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

STAM1_MOUSE
NC score	0.225244 (rank : 104)	θ value	0.0736092 (rank : 89)
Query Neighborhood Hits	187	Target Neighborhood Hits	273	Shared Neighborhood Hits	94
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PDZD3_MOUSE
NC score	0.225141 (rank : 105)	θ value	2.36792 (rank : 147)
Query Neighborhood Hits	187	Target Neighborhood Hits	171	Shared Neighborhood Hits	85
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PZRN4_HUMAN
NC score	0.220895 (rank : 106)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	187	Target Neighborhood Hits	438	Shared Neighborhood Hits	87
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

NHRF2_HUMAN
NC score	0.217530 (rank : 107)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	187	Target Neighborhood Hits	197	Shared Neighborhood Hits	87
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

STAM1_HUMAN
NC score	0.217415 (rank : 108)	θ value	0.0252991 (rank : 70)
Query Neighborhood Hits	187	Target Neighborhood Hits	271	Shared Neighborhood Hits	93
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NEB1_HUMAN
NC score	0.215750 (rank : 109)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	187	Target Neighborhood Hits	829	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PZRN3_HUMAN
NC score	0.212082 (rank : 110)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	187	Target Neighborhood Hits	461	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
NC score	0.210785 (rank : 111)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	187	Target Neighborhood Hits	447	Shared Neighborhood Hits	85
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

CACB4_HUMAN
NC score	0.210735 (rank : 112)	θ value	0.00509761 (rank : 60)
Query Neighborhood Hits	187	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

NHERF_MOUSE
NC score	0.210167 (rank : 113)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	187	Target Neighborhood Hits	195	Shared Neighborhood Hits	81
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NPHP1_MOUSE
NC score	0.210076 (rank : 114)	θ value	0.0563607 (rank : 83)
Query Neighborhood Hits	187	Target Neighborhood Hits	267	Shared Neighborhood Hits	90
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STAM2_MOUSE
NC score	0.208308 (rank : 115)	θ value	0.0961366 (rank : 93)
Query Neighborhood Hits	187	Target Neighborhood Hits	285	Shared Neighborhood Hits	90
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

CACB4_MOUSE
NC score	0.208012 (rank : 116)	θ value	0.00390308 (rank : 55)
Query Neighborhood Hits	187	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CRKL_MOUSE
NC score	0.207795 (rank : 117)	θ value	0.0736092 (rank : 85)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CACB3_MOUSE
NC score	0.206453 (rank : 118)	θ value	0.0330416 (rank : 72)
Query Neighborhood Hits	187	Target Neighborhood Hits	48	Shared Neighborhood Hits	30
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

CACB3_HUMAN
NC score	0.204899 (rank : 119)	θ value	0.0563607 (rank : 82)
Query Neighborhood Hits	187	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CRKL_HUMAN
NC score	0.204235 (rank : 120)	θ value	0.0431538 (rank : 76)
Query Neighborhood Hits	187	Target Neighborhood Hits	313	Shared Neighborhood Hits	91
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NHERF_HUMAN
NC score	0.200607 (rank : 121)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	187	Target Neighborhood Hits	190	Shared Neighborhood Hits	79
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NEB2_HUMAN
NC score	0.194098 (rank : 122)	θ value	4.03905 (rank : 160)
Query Neighborhood Hits	187	Target Neighborhood Hits	883	Shared Neighborhood Hits	91
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
NC score	0.191719 (rank : 123)	θ value	4.03905 (rank : 161)
Query Neighborhood Hits	187	Target Neighborhood Hits	889	Shared Neighborhood Hits	91
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

SDCB1_HUMAN
NC score	0.189271 (rank : 124)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	187	Target Neighborhood Hits	150	Shared Neighborhood Hits	79
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

K1849_MOUSE
NC score	0.185875 (rank : 125)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	187	Target Neighborhood Hits	335	Shared Neighborhood Hits	84
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

STAM2_HUMAN
NC score	0.184869 (rank : 126)	θ value	0.365318 (rank : 119)
Query Neighborhood Hits	187	Target Neighborhood Hits	288	Shared Neighborhood Hits	92
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SDCB1_MOUSE
NC score	0.184099 (rank : 127)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	187	Target Neighborhood Hits	144	Shared Neighborhood Hits	71
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

AFAD_HUMAN
NC score	0.183563 (rank : 128)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	187	Target Neighborhood Hits	689	Shared Neighborhood Hits	87
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

SDCB2_HUMAN
NC score	0.183553 (rank : 129)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	187	Target Neighborhood Hits	121	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PTN13_HUMAN
NC score	0.181558 (rank : 130)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	187	Target Neighborhood Hits	471	Shared Neighborhood Hits	98
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN13_MOUSE
NC score	0.178778 (rank : 131)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	187	Target Neighborhood Hits	426	Shared Neighborhood Hits	96
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

K1849_HUMAN
NC score	0.178152 (rank : 132)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	187	Target Neighborhood Hits	220	Shared Neighborhood Hits	81
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

GRAP_MOUSE
NC score	0.176823 (rank : 133)	θ value	0.00665767 (rank : 61)
Query Neighborhood Hits	187	Target Neighborhood Hits	309	Shared Neighborhood Hits	93
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PICK1_MOUSE
NC score	0.176785 (rank : 134)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	187	Target Neighborhood Hits	131	Shared Neighborhood Hits	77
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

CACB2_HUMAN
NC score	0.174820 (rank : 135)	θ value	0.163984 (rank : 97)
Query Neighborhood Hits	187	Target Neighborhood Hits	99	Shared Neighborhood Hits	27
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

NOS1_HUMAN
NC score	0.174588 (rank : 136)	θ value	0.62314 (rank : 126)
Query Neighborhood Hits	187	Target Neighborhood Hits	218	Shared Neighborhood Hits	85
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PICK1_HUMAN
NC score	0.174570 (rank : 137)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	187	Target Neighborhood Hits	132	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SDCB2_MOUSE
NC score	0.174507 (rank : 138)	θ value	2.36792 (rank : 149)
Query Neighborhood Hits	187	Target Neighborhood Hits	118	Shared Neighborhood Hits	67
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

DVL3_HUMAN
NC score	0.173850 (rank : 139)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	187	Target Neighborhood Hits	194	Shared Neighborhood Hits	74
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
NC score	0.173696 (rank : 140)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	74
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1_HUMAN
NC score	0.172196 (rank : 141)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	187	Target Neighborhood Hits	158	Shared Neighborhood Hits	76
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
NC score	0.172195 (rank : 142)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	187	Target Neighborhood Hits	146	Shared Neighborhood Hits	75
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

GRAP_HUMAN
NC score	0.170114 (rank : 143)	θ value	0.163984 (rank : 98)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CACB2_MOUSE
NC score	0.168338 (rank : 144)	θ value	0.365318 (rank : 114)
Query Neighborhood Hits	187	Target Neighborhood Hits	94	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CC27, Q8C5J5, Q9CTQ6	Gene names	Cacnb2, Cacnlb2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).

ARHG7_MOUSE
NC score	0.166537 (rank : 145)	θ value	0.00869519 (rank : 63)
Query Neighborhood Hits	187	Target Neighborhood Hits	396	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DVL1L_HUMAN
NC score	0.166207 (rank : 146)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	187	Target Neighborhood Hits	146	Shared Neighborhood Hits	76
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

SH3K1_MOUSE
NC score	0.164462 (rank : 147)	θ value	0.0961366 (rank : 91)
Query Neighborhood Hits	187	Target Neighborhood Hits	332	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.164089 (rank : 148)	θ value	0.0330416 (rank : 75)
Query Neighborhood Hits	187	Target Neighborhood Hits	341	Shared Neighborhood Hits	82
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

OSTF1_HUMAN
NC score	0.162452 (rank : 149)	θ value	0.0431538 (rank : 80)
Query Neighborhood Hits	187	Target Neighborhood Hits	466	Shared Neighborhood Hits	94
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ARHG7_HUMAN
NC score	0.158467 (rank : 150)	θ value	0.0736092 (rank : 84)
Query Neighborhood Hits	187	Target Neighborhood Hits	347	Shared Neighborhood Hits	88
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GIPC1_MOUSE
NC score	0.157789 (rank : 151)	θ value	0.47712 (rank : 122)
Query Neighborhood Hits	187	Target Neighborhood Hits	92	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

NOS1_MOUSE
NC score	0.153812 (rank : 152)	θ value	3.0926 (rank : 154)
Query Neighborhood Hits	187	Target Neighborhood Hits	155	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

STXB4_HUMAN
NC score	0.151979 (rank : 153)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	187	Target Neighborhood Hits	616	Shared Neighborhood Hits	74
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

DVL2_HUMAN
NC score	0.151458 (rank : 154)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	187	Target Neighborhood Hits	223	Shared Neighborhood Hits	71
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
NC score	0.150078 (rank : 155)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	187	Target Neighborhood Hits	233	Shared Neighborhood Hits	72
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

STXB4_MOUSE
NC score	0.148288 (rank : 156)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	187	Target Neighborhood Hits	629	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

NPHP1_HUMAN
NC score	0.147278 (rank : 157)	θ value	0.0193708 (rank : 65)
Query Neighborhood Hits	187	Target Neighborhood Hits	288	Shared Neighborhood Hits	74
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

CD2AP_MOUSE
NC score	0.146786 (rank : 158)	θ value	1.38821 (rank : 142)
Query Neighborhood Hits	187	Target Neighborhood Hits	336	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

GIPC1_HUMAN
NC score	0.145515 (rank : 159)	θ value	1.06291 (rank : 136)
Query Neighborhood Hits	187	Target Neighborhood Hits	91	Shared Neighborhood Hits	66
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

PDZK4_HUMAN
NC score	0.144201 (rank : 160)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	187	Target Neighborhood Hits	165	Shared Neighborhood Hits	72
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

ITSN2_HUMAN
NC score	0.143860 (rank : 161)	θ value	0.000158464 (rank : 36)
Query Neighborhood Hits	187	Target Neighborhood Hits	1173	Shared Neighborhood Hits	99
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
NC score	0.140900 (rank : 162)	θ value	5.44631e-05 (rank : 31)
Query Neighborhood Hits	187	Target Neighborhood Hits	1371	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

RIMB2_HUMAN
NC score	0.139392 (rank : 163)	θ value	0.47712 (rank : 123)
Query Neighborhood Hits	187	Target Neighborhood Hits	263	Shared Neighborhood Hits	65
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

OSTF1_MOUSE
NC score	0.139385 (rank : 164)	θ value	0.365318 (rank : 117)
Query Neighborhood Hits	187	Target Neighborhood Hits	467	Shared Neighborhood Hits	93
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

GIPC2_HUMAN
NC score	0.137491 (rank : 165)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	187	Target Neighborhood Hits	93	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

ITSN1_MOUSE
NC score	0.136940 (rank : 166)	θ value	4.92598e-06 (rank : 27)
Query Neighborhood Hits	187	Target Neighborhood Hits	1669	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RIMB2_MOUSE
NC score	0.135682 (rank : 167)	θ value	0.813845 (rank : 134)
Query Neighborhood Hits	187	Target Neighborhood Hits	246	Shared Neighborhood Hits	63
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ITSN1_HUMAN
NC score	0.134886 (rank : 168)	θ value	1.09739e-05 (rank : 29)
Query Neighborhood Hits	187	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PDZK4_MOUSE
NC score	0.134120 (rank : 169)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	187	Target Neighborhood Hits	165	Shared Neighborhood Hits	71
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

CD2AP_HUMAN
NC score	0.131777 (rank : 170)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	187	Target Neighborhood Hits	315	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3G2_MOUSE
NC score	0.126885 (rank : 171)	θ value	2.36792 (rank : 151)
Query Neighborhood Hits	187	Target Neighborhood Hits	319	Shared Neighborhood Hits	80
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PDLI2_HUMAN
NC score	0.126378 (rank : 172)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	187	Target Neighborhood Hits	245	Shared Neighborhood Hits	60
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

NCK1_HUMAN
NC score	0.126342 (rank : 173)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	85
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3G2_HUMAN
NC score	0.125649 (rank : 174)	θ value	1.06291 (rank : 141)
Query Neighborhood Hits	187	Target Neighborhood Hits	324	Shared Neighborhood Hits	83
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

GRAP2_HUMAN
NC score	0.124216 (rank : 175)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	187	Target Neighborhood Hits	304	Shared Neighborhood Hits	88
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SH3G3_HUMAN
NC score	0.123666 (rank : 176)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	187	Target Neighborhood Hits	222	Shared Neighborhood Hits	78
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G1_HUMAN
NC score	0.122881 (rank : 177)	θ value	2.36792 (rank : 150)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	80
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
NC score	0.122693 (rank : 178)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	187	Target Neighborhood Hits	291	Shared Neighborhood Hits	82
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_MOUSE
NC score	0.122402 (rank : 179)	θ value	4.03905 (rank : 162)
Query Neighborhood Hits	187	Target Neighborhood Hits	236	Shared Neighborhood Hits	81
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

NCF2_HUMAN
NC score	0.121713 (rank : 180)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	187	Target Neighborhood Hits	229	Shared Neighborhood Hits	75
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

GRAP2_MOUSE
NC score	0.121230 (rank : 181)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	85
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ARHGC_HUMAN
NC score	0.120319 (rank : 182)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	187	Target Neighborhood Hits	351	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG6_HUMAN
NC score	0.118714 (rank : 183)	θ value	0.21417 (rank : 103)
Query Neighborhood Hits	187	Target Neighborhood Hits	376	Shared Neighborhood Hits	77
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHGB_HUMAN
NC score	0.116721 (rank : 184)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	187	Target Neighborhood Hits	375	Shared Neighborhood Hits	80
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG6_MOUSE
NC score	0.116152 (rank : 185)	θ value	0.813845 (rank : 129)
Query Neighborhood Hits	187	Target Neighborhood Hits	394	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

RHPN1_MOUSE
NC score	0.115810 (rank : 186)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	187	Target Neighborhood Hits	154	Shared Neighborhood Hits	64
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

ARHGC_MOUSE
NC score	0.113697 (rank : 187)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	187	Target Neighborhood Hits	344	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RGS12_HUMAN
NC score	0.110247 (rank : 188)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	187	Target Neighborhood Hits	333	Shared Neighborhood Hits	65
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

ABI2_HUMAN
NC score	0.109354 (rank : 189)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	187	Target Neighborhood Hits	350	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.108696 (rank : 190)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	81
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

RPGF6_HUMAN
NC score	0.106252 (rank : 191)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

VINEX_HUMAN
NC score	0.103210 (rank : 192)	θ value	4.03905 (rank : 163)
Query Neighborhood Hits	187	Target Neighborhood Hits	270	Shared Neighborhood Hits	76
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SHAN2_MOUSE
NC score	0.102951 (rank : 193)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	187	Target Neighborhood Hits	446	Shared Neighborhood Hits	113
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SRBS1_MOUSE
NC score	0.102831 (rank : 194)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	187	Target Neighborhood Hits	409	Shared Neighborhood Hits	83
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.101620 (rank : 195)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	187	Target Neighborhood Hits	396	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PCLO_MOUSE
NC score	0.100945 (rank : 196)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	187	Target Neighborhood Hits	2275	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RHPN1_HUMAN
NC score	0.100133 (rank : 197)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	187	Target Neighborhood Hits	158	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PPIP1_HUMAN
NC score	0.098933 (rank : 198)	θ value	0.163984 (rank : 99)
Query Neighborhood Hits	187	Target Neighborhood Hits	389	Shared Neighborhood Hits	86
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRASP_HUMAN
NC score	0.097840 (rank : 199)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	187	Target Neighborhood Hits	147	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
NC score	0.095634 (rank : 200)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	187	Target Neighborhood Hits	131	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

PDLI2_MOUSE
NC score	0.094897 (rank : 201)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	187	Target Neighborhood Hits	220	Shared Neighborhood Hits	59
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDZD6_HUMAN
NC score	0.094440 (rank : 202)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	187	Target Neighborhood Hits	81	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

ABI1_MOUSE
NC score	0.093919 (rank : 203)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	187	Target Neighborhood Hits	246	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

RHG04_HUMAN
NC score	0.093753 (rank : 204)	θ value	0.365318 (rank : 118)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	83
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NCK2_HUMAN
NC score	0.093677 (rank : 205)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	187	Target Neighborhood Hits	310	Shared Neighborhood Hits	74
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCF1_HUMAN
NC score	0.093303 (rank : 206)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	71
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

RIMS1_HUMAN
NC score	0.093024 (rank : 207)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	187	Target Neighborhood Hits	437	Shared Neighborhood Hits	83
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

STAC_MOUSE
NC score	0.092087 (rank : 208)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	187	Target Neighborhood Hits	268	Shared Neighborhood Hits	80
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PACN1_HUMAN
NC score	0.091296 (rank : 209)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	187	Target Neighborhood Hits	320	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

STAC_HUMAN
NC score	0.090807 (rank : 210)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	187	Target Neighborhood Hits	276	Shared Neighborhood Hits	82
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PLCG1_MOUSE
NC score	0.090698 (rank : 211)	θ value	0.0961366 (rank : 90)
Query Neighborhood Hits	187	Target Neighborhood Hits	314	Shared Neighborhood Hits	72
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RPGF2_HUMAN
NC score	0.090299 (rank : 212)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	187	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

PPIP1_MOUSE
NC score	0.089652 (rank : 213)	θ value	3.0926 (rank : 155)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	86
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

VINEX_MOUSE
NC score	0.088996 (rank : 214)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	187	Target Neighborhood Hits	286	Shared Neighborhood Hits	75
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ABI1_HUMAN
NC score	0.087879 (rank : 215)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	187	Target Neighborhood Hits	257	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CAR11_HUMAN
NC score	0.086371 (rank : 216)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	187	Target Neighborhood Hits	690	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

APXL_HUMAN
NC score	0.085789 (rank : 217)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	187	Target Neighborhood Hits	553	Shared Neighborhood Hits	51
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

NCF1_MOUSE
NC score	0.085771 (rank : 218)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	71
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PACN1_MOUSE
NC score	0.085022 (rank : 219)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	187	Target Neighborhood Hits	283	Shared Neighborhood Hits	79
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_MOUSE
NC score	0.084073 (rank : 220)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	187	Target Neighborhood Hits	382	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

LRRC7_HUMAN
NC score	0.084002 (rank : 221)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	187	Target Neighborhood Hits	423	Shared Neighborhood Hits	61
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.083801 (rank : 222)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	187	Target Neighborhood Hits	416	Shared Neighborhood Hits	61
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

SHAN2_HUMAN
NC score	0.083651 (rank : 223)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	187	Target Neighborhood Hits	346	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

LAP2_HUMAN
NC score	0.083204 (rank : 224)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	187	Target Neighborhood Hits	499	Shared Neighborhood Hits	58
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PLCG1_HUMAN
NC score	0.082608 (rank : 225)	θ value	0.62314 (rank : 127)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	70
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PSCBP_MOUSE
NC score	0.082329 (rank : 226)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	187	Target Neighborhood Hits	118	Shared Neighborhood Hits	54
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SHAN1_HUMAN
NC score	0.081883 (rank : 227)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	187	Target Neighborhood Hits	1041	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

RIMB1_MOUSE
NC score	0.081880 (rank : 228)	θ value	0.279714 (rank : 111)
Query Neighborhood Hits	187	Target Neighborhood Hits	1376	Shared Neighborhood Hits	86
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CAR14_HUMAN
NC score	0.081722 (rank : 229)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	187	Target Neighborhood Hits	449	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

SPN90_HUMAN
NC score	0.081595 (rank : 230)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	187	Target Neighborhood Hits	157	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

PDLI3_HUMAN
NC score	0.081527 (rank : 231)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	187	Target Neighborhood Hits	199	Shared Neighborhood Hits	58
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

RIMB1_HUMAN
NC score	0.080495 (rank : 232)	θ value	0.62314 (rank : 128)
Query Neighborhood Hits	187	Target Neighborhood Hits	1479	Shared Neighborhood Hits	84
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SYP2L_HUMAN
NC score	0.079940 (rank : 233)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	187	Target Neighborhood Hits	400	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

LAP2_MOUSE
NC score	0.079890 (rank : 234)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	187	Target Neighborhood Hits	482	Shared Neighborhood Hits	59
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

GIPC3_HUMAN
NC score	0.078320 (rank : 235)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	187	Target Neighborhood Hits	52	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

SRGP2_MOUSE
NC score	0.077985 (rank : 236)	θ value	0.163984 (rank : 101)
Query Neighborhood Hits	187	Target Neighborhood Hits	324	Shared Neighborhood Hits	75
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

PSCBP_HUMAN
NC score	0.077798 (rank : 237)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	187	Target Neighborhood Hits	123	Shared Neighborhood Hits	56
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

ARHG4_HUMAN
NC score	0.077572 (rank : 238)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	187	Target Neighborhood Hits	242	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PACN2_HUMAN
NC score	0.077525 (rank : 239)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	187	Target Neighborhood Hits	339	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RIMS2_HUMAN
NC score	0.076418 (rank : 240)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	187	Target Neighborhood Hits	342	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

GIPC3_MOUSE
NC score	0.076121 (rank : 241)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	187	Target Neighborhood Hits	53	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

RIMS2_MOUSE
NC score	0.075883 (rank : 242)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	187	Target Neighborhood Hits	376	Shared Neighborhood Hits	76
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

GIPC2_MOUSE
NC score	0.075709 (rank : 243)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	187	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

SRGP2_HUMAN
NC score	0.075587 (rank : 244)	θ value	0.47712 (rank : 124)
Query Neighborhood Hits	187	Target Neighborhood Hits	331	Shared Neighborhood Hits	74
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP1_HUMAN
NC score	0.075447 (rank : 245)	θ value	0.279714 (rank : 112)
Query Neighborhood Hits	187	Target Neighborhood Hits	390	Shared Neighborhood Hits	74
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

AHI1_HUMAN
NC score	0.075385 (rank : 246)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	187	Target Neighborhood Hits	537	Shared Neighborhood Hits	79
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

FNBP2_HUMAN
NC score	0.074559 (rank : 247)	θ value	0.21417 (rank : 104)
Query Neighborhood Hits	187	Target Neighborhood Hits	432	Shared Neighborhood Hits	72
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

DNMBP_HUMAN
NC score	0.074290 (rank : 248)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	187	Target Neighborhood Hits	413	Shared Neighborhood Hits	78
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
NC score	0.071540 (rank : 249)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	187	Target Neighborhood Hits	435	Shared Neighborhood Hits	77
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PLCG2_HUMAN
NC score	0.070945 (rank : 250)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	187	Target Neighborhood Hits	280	Shared Neighborhood Hits	69
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NCF4_MOUSE
NC score	0.070851 (rank : 251)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	187	Target Neighborhood Hits	177	Shared Neighborhood Hits	63
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ARHG9_HUMAN
NC score	0.068531 (rank : 252)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	187	Target Neighborhood Hits	235	Shared Neighborhood Hits	74
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

PDLI4_MOUSE
NC score	0.068469 (rank : 253)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	187	Target Neighborhood Hits	233	Shared Neighborhood Hits	56
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

AHI1_MOUSE
NC score	0.068453 (rank : 254)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	187	Target Neighborhood Hits	496	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG9_MOUSE
NC score	0.068264 (rank : 255)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	187	Target Neighborhood Hits	234	Shared Neighborhood Hits	73
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

VAV2_MOUSE
NC score	0.068136 (rank : 256)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	187	Target Neighborhood Hits	456	Shared Neighborhood Hits	70
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

STAC3_MOUSE
NC score	0.067891 (rank : 257)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	187	Target Neighborhood Hits	232	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.067567 (rank : 258)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	187	Target Neighborhood Hits	228	Shared Neighborhood Hits	66
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG4_MOUSE
NC score	0.067421 (rank : 259)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	187	Target Neighborhood Hits	185	Shared Neighborhood Hits	60
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

HCLS1_MOUSE
NC score	0.067315 (rank : 260)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	187	Target Neighborhood Hits	329	Shared Neighborhood Hits	68
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.066793 (rank : 261)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	187	Target Neighborhood Hits	358	Shared Neighborhood Hits	68
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

VAV2_HUMAN
NC score	0.066656 (rank : 262)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	187	Target Neighborhood Hits	453	Shared Neighborhood Hits	71
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.066088 (rank : 263)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	187	Target Neighborhood Hits	430	Shared Neighborhood Hits	75
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

PDLI3_MOUSE
NC score	0.066080 (rank : 264)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	187	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

YES_MOUSE
NC score	0.065008 (rank : 265)	θ value	0.0193708 (rank : 66)
Query Neighborhood Hits	187	Target Neighborhood Hits	1052	Shared Neighborhood Hits	93
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.064893 (rank : 266)	θ value	0.0736092 (rank : 87)
Query Neighborhood Hits	187	Target Neighborhood Hits	1073	Shared Neighborhood Hits	89
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

PACN3_MOUSE
NC score	0.064259 (rank : 267)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	187	Target Neighborhood Hits	380	Shared Neighborhood Hits	78
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SRC8_MOUSE
NC score	0.063986 (rank : 268)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	187	Target Neighborhood Hits	292	Shared Neighborhood Hits	71
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

FYN_HUMAN
NC score	0.063771 (rank : 269)	θ value	0.0736092 (rank : 86)
Query Neighborhood Hits	187	Target Neighborhood Hits	1078	Shared Neighborhood Hits	89
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SYNP2_MOUSE
NC score	0.063551 (rank : 270)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	187	Target Neighborhood Hits	252	Shared Neighborhood Hits	56
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

VAV_HUMAN
NC score	0.063470 (rank : 271)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	187	Target Neighborhood Hits	452	Shared Neighborhood Hits	71
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SRC8_HUMAN
NC score	0.063308 (rank : 272)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	187	Target Neighborhood Hits	269	Shared Neighborhood Hits	70
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

FGR_HUMAN
NC score	0.063157 (rank : 273)	θ value	0.125558 (rank : 94)
Query Neighborhood Hits	187	Target Neighborhood Hits	1067	Shared Neighborhood Hits	93
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ASPP2_HUMAN
NC score	0.063142 (rank : 274)	θ value	0.365318 (rank : 113)
Query Neighborhood Hits	187	Target Neighborhood Hits	1156	Shared Neighborhood Hits	81
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

YES_HUMAN
NC score	0.062524 (rank : 275)	θ value	0.0431538 (rank : 81)
Query Neighborhood Hits	187	Target Neighborhood Hits	1059	Shared Neighborhood Hits	91
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PACN3_HUMAN
NC score	0.062216 (rank : 276)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	187	Target Neighborhood Hits	385	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NCF4_HUMAN
NC score	0.062203 (rank : 277)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	187	Target Neighborhood Hits	161	Shared Neighborhood Hits	55
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DDEF1_MOUSE
NC score	0.062020 (rank : 278)	θ value	4.03905 (rank : 159)
Query Neighborhood Hits	187	Target Neighborhood Hits	592	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

PDLI4_HUMAN
NC score	0.061133 (rank : 279)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	187	Target Neighborhood Hits	245	Shared Neighborhood Hits	52
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

SPN90_MOUSE
NC score	0.059650 (rank : 280)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	187	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

RUSC1_HUMAN
NC score	0.057984 (rank : 281)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	187	Target Neighborhood Hits	226	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

LMO7_HUMAN
NC score	0.057954 (rank : 282)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	187	Target Neighborhood Hits	507	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

ABI3_HUMAN
NC score	0.057405 (rank : 283)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NOXO1_MOUSE
NC score	0.057315 (rank : 284)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	187	Target Neighborhood Hits	114	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PRAX_MOUSE
NC score	0.057137 (rank : 285)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	187	Target Neighborhood Hits	199	Shared Neighborhood Hits	27
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

VAV3_HUMAN
NC score	0.057090 (rank : 286)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	187	Target Neighborhood Hits	398	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ABI3_MOUSE
NC score	0.056970 (rank : 287)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

RHG12_HUMAN
NC score	0.056592 (rank : 288)	θ value	0.813845 (rank : 133)
Query Neighborhood Hits	187	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

ANM2_MOUSE
NC score	0.056298 (rank : 289)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_HUMAN
NC score	0.056209 (rank : 290)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	68
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PDZD8_HUMAN
NC score	0.055484 (rank : 291)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	187	Target Neighborhood Hits	185	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

FRK_HUMAN
NC score	0.055427 (rank : 292)	θ value	1.06291 (rank : 135)
Query Neighborhood Hits	187	Target Neighborhood Hits	1058	Shared Neighborhood Hits	89
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

VAV3_MOUSE
NC score	0.055380 (rank : 293)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	187	Target Neighborhood Hits	404	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SRC_HUMAN
NC score	0.055080 (rank : 294)	θ value	0.00228821 (rank : 52)
Query Neighborhood Hits	187	Target Neighborhood Hits	1058	Shared Neighborhood Hits	95
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FGR_MOUSE
NC score	0.055034 (rank : 295)	θ value	0.62314 (rank : 125)
Query Neighborhood Hits	187	Target Neighborhood Hits	1069	Shared Neighborhood Hits	90
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLAP2_MOUSE
NC score	0.054747 (rank : 296)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	187	Target Neighborhood Hits	136	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

PEX13_MOUSE
NC score	0.054675 (rank : 297)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	187	Target Neighborhood Hits	126	Shared Neighborhood Hits	48
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

DBNL_HUMAN
NC score	0.053827 (rank : 298)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	187	Target Neighborhood Hits	244	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
NC score	0.052876 (rank : 299)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	187	Target Neighborhood Hits	306	Shared Neighborhood Hits	61
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SLAP2_HUMAN
NC score	0.052512 (rank : 300)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	187	Target Neighborhood Hits	139	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

PDLI1_MOUSE
NC score	0.052500 (rank : 301)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	187	Target Neighborhood Hits	213	Shared Neighborhood Hits	50
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

CASL_HUMAN
NC score	0.050213 (rank : 302)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	187	Target Neighborhood Hits	259	Shared Neighborhood Hits	64
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

LASP1_HUMAN
NC score	0.050155 (rank : 303)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	60
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

TXK_MOUSE
NC score	0.048621 (rank : 304)	θ value	0.0252991 (rank : 71)
Query Neighborhood Hits	187	Target Neighborhood Hits	980	Shared Neighborhood Hits	73
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

RHG12_MOUSE
NC score	0.047401 (rank : 305)	θ value	2.36792 (rank : 148)
Query Neighborhood Hits	187	Target Neighborhood Hits	204	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TXK_HUMAN
NC score	0.044361 (rank : 306)	θ value	0.163984 (rank : 102)
Query Neighborhood Hits	187	Target Neighborhood Hits	971	Shared Neighborhood Hits	66
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

PTK6_HUMAN
NC score	0.041983 (rank : 307)	θ value	3.0926 (rank : 156)
Query Neighborhood Hits	187	Target Neighborhood Hits	1020	Shared Neighborhood Hits	82
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

BTK_MOUSE
NC score	0.041091 (rank : 308)	θ value	0.163984 (rank : 96)
Query Neighborhood Hits	187	Target Neighborhood Hits	1017	Shared Neighborhood Hits	80
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BTK_HUMAN
NC score	0.040963 (rank : 309)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	187	Target Neighborhood Hits	1026	Shared Neighborhood Hits	79
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DDEF2_HUMAN
NC score	0.040085 (rank : 310)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	187	Target Neighborhood Hits	599	Shared Neighborhood Hits	60
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SRC_MOUSE
NC score	0.035969 (rank : 311)	θ value	0.163984 (rank : 100)
Query Neighborhood Hits	187	Target Neighborhood Hits	1033	Shared Neighborhood Hits	75
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

UBE4A_HUMAN
NC score	0.034639 (rank : 312)	θ value	0.365318 (rank : 120)
Query Neighborhood Hits	187	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q14139, Q6P5T4, Q7Z639	Gene names	UBE4A, KIAA0126
Domain Architecture	No domain graphic available
Description	Ubiquitin conjugation factor E4 A.

LIMK1_MOUSE
NC score	0.033542 (rank : 313)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	187	Target Neighborhood Hits	1008	Shared Neighborhood Hits	61
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

MY18A_HUMAN
NC score	0.033284 (rank : 314)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	187	Target Neighborhood Hits	1929	Shared Neighborhood Hits	100
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PRLPE_MOUSE
NC score	0.017530 (rank : 315)	θ value	1.38821 (rank : 143)
Query Neighborhood Hits	187	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O54830, O35334, Q80X21	Gene names	Prlpe, Prlpg
Domain Architecture	No domain graphic available
Description	Placental prolactin-like protein E precursor (PRL-like protein E) (PLP-E) (Placental prolactin-like protein G) (PRL-like protein G) (PLP-G).

MX2_MOUSE
NC score	0.016094 (rank : 316)	θ value	0.813845 (rank : 130)
Query Neighborhood Hits	187	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WVP9, Q922L4	Gene names	Mx2
Domain Architecture	No domain graphic available
Description	Interferon-induced GTP-binding protein Mx2.

CENPF_HUMAN
NC score	0.009873 (rank : 317)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	187	Target Neighborhood Hits	1932	Shared Neighborhood Hits	39
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

SF3B2_HUMAN
NC score	0.009661 (rank : 318)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	187	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

3BP2_MOUSE
NC score	0.008302 (rank : 319)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	187	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CK5P2_HUMAN
NC score	0.008043 (rank : 320)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	187	Target Neighborhood Hits	1433	Shared Neighborhood Hits	29
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).