Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : ZO3_HUMAN

For an explanation of this page, click here

ZO3_HUMAN
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ZO3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	219	Target Neighborhood Hits	219	Shared Neighborhood Hits	219
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
θ value	0 (rank : 2)	NC score	0.987504 (rank : 2)
Query Neighborhood Hits	219	Target Neighborhood Hits	224	Shared Neighborhood Hits	185
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO1_MOUSE
θ value	9.45368e-175 (rank : 3)	NC score	0.919726 (rank : 5)
Query Neighborhood Hits	219	Target Neighborhood Hits	453	Shared Neighborhood Hits	183
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_HUMAN
θ value	3.97187e-173 (rank : 4)	NC score	0.916742 (rank : 6)
Query Neighborhood Hits	219	Target Neighborhood Hits	474	Shared Neighborhood Hits	181
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO2_MOUSE
θ value	1.20145e-153 (rank : 5)	NC score	0.948925 (rank : 3)
Query Neighborhood Hits	219	Target Neighborhood Hits	296	Shared Neighborhood Hits	168
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_HUMAN
θ value	6.59259e-152 (rank : 6)	NC score	0.946385 (rank : 4)
Query Neighborhood Hits	219	Target Neighborhood Hits	289	Shared Neighborhood Hits	167
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

DLG2_HUMAN
θ value	4.88048e-38 (rank : 7)	NC score	0.776409 (rank : 7)
Query Neighborhood Hits	219	Target Neighborhood Hits	279	Shared Neighborhood Hits	171
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	4.568e-36 (rank : 8)	NC score	0.776156 (rank : 9)
Query Neighborhood Hits	219	Target Neighborhood Hits	271	Shared Neighborhood Hits	169
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG5_HUMAN
θ value	3.3877e-31 (rank : 9)	NC score	0.562045 (rank : 45)
Query Neighborhood Hits	219	Target Neighborhood Hits	1088	Shared Neighborhood Hits	169
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DLG3_HUMAN
θ value	5.77852e-31 (rank : 10)	NC score	0.773024 (rank : 11)
Query Neighborhood Hits	219	Target Neighborhood Hits	269	Shared Neighborhood Hits	172
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	8.3442e-30 (rank : 11)	NC score	0.771774 (rank : 12)
Query Neighborhood Hits	219	Target Neighborhood Hits	274	Shared Neighborhood Hits	172
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG4_HUMAN
θ value	2.42779e-29 (rank : 12)	NC score	0.775618 (rank : 10)
Query Neighborhood Hits	219	Target Neighborhood Hits	286	Shared Neighborhood Hits	176
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	3.17079e-29 (rank : 13)	NC score	0.776251 (rank : 8)
Query Neighborhood Hits	219	Target Neighborhood Hits	282	Shared Neighborhood Hits	176
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG1_HUMAN
θ value	5.40856e-29 (rank : 14)	NC score	0.766978 (rank : 14)
Query Neighborhood Hits	219	Target Neighborhood Hits	290	Shared Neighborhood Hits	168
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	7.06379e-29 (rank : 15)	NC score	0.768206 (rank : 13)
Query Neighborhood Hits	219	Target Neighborhood Hits	285	Shared Neighborhood Hits	166
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

MPP5_HUMAN
θ value	9.90251e-15 (rank : 16)	NC score	0.587901 (rank : 33)
Query Neighborhood Hits	219	Target Neighborhood Hits	231	Shared Neighborhood Hits	129
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	2.20605e-14 (rank : 17)	NC score	0.586971 (rank : 34)
Query Neighborhood Hits	219	Target Neighborhood Hits	226	Shared Neighborhood Hits	129
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MAGI1_MOUSE
θ value	2.0648e-12 (rank : 18)	NC score	0.575354 (rank : 42)
Query Neighborhood Hits	219	Target Neighborhood Hits	403	Shared Neighborhood Hits	177
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
θ value	2.69671e-12 (rank : 19)	NC score	0.578738 (rank : 40)
Query Neighborhood Hits	219	Target Neighborhood Hits	388	Shared Neighborhood Hits	174
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI2_MOUSE
θ value	2.69671e-12 (rank : 20)	NC score	0.562197 (rank : 44)
Query Neighborhood Hits	219	Target Neighborhood Hits	370	Shared Neighborhood Hits	174
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

LNX1_MOUSE
θ value	1.02475e-11 (rank : 21)	NC score	0.583141 (rank : 36)
Query Neighborhood Hits	219	Target Neighborhood Hits	377	Shared Neighborhood Hits	160
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

INADL_MOUSE
θ value	1.33837e-11 (rank : 22)	NC score	0.659855 (rank : 16)
Query Neighborhood Hits	219	Target Neighborhood Hits	290	Shared Neighborhood Hits	176
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MAGI2_HUMAN
θ value	2.28291e-11 (rank : 23)	NC score	0.555400 (rank : 49)
Query Neighborhood Hits	219	Target Neighborhood Hits	373	Shared Neighborhood Hits	170
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

INADL_HUMAN
θ value	6.64225e-11 (rank : 24)	NC score	0.646526 (rank : 17)
Query Neighborhood Hits	219	Target Neighborhood Hits	260	Shared Neighborhood Hits	174
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

LNX1_HUMAN
θ value	1.63604e-09 (rank : 25)	NC score	0.577228 (rank : 41)
Query Neighborhood Hits	219	Target Neighborhood Hits	379	Shared Neighborhood Hits	155
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MPP2_MOUSE
θ value	4.76016e-09 (rank : 26)	NC score	0.484220 (rank : 74)
Query Neighborhood Hits	219	Target Neighborhood Hits	189	Shared Neighborhood Hits	94
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

PZRN3_HUMAN
θ value	4.76016e-09 (rank : 27)	NC score	0.507214 (rank : 64)
Query Neighborhood Hits	219	Target Neighborhood Hits	461	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

CAR14_MOUSE
θ value	6.21693e-09 (rank : 28)	NC score	0.235007 (rank : 149)
Query Neighborhood Hits	219	Target Neighborhood Hits	526	Shared Neighborhood Hits	34
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

LNX2_MOUSE
θ value	1.06045e-08 (rank : 29)	NC score	0.586719 (rank : 35)
Query Neighborhood Hits	219	Target Neighborhood Hits	407	Shared Neighborhood Hits	167
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

CAR14_HUMAN
θ value	1.38499e-08 (rank : 30)	NC score	0.266929 (rank : 133)
Query Neighborhood Hits	219	Target Neighborhood Hits	449	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

MPP2_HUMAN
θ value	1.38499e-08 (rank : 31)	NC score	0.480182 (rank : 76)
Query Neighborhood Hits	219	Target Neighborhood Hits	173	Shared Neighborhood Hits	89
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

WHRN_HUMAN
θ value	1.38499e-08 (rank : 32)	NC score	0.612429 (rank : 22)
Query Neighborhood Hits	219	Target Neighborhood Hits	325	Shared Neighborhood Hits	174
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

CAR11_HUMAN
θ value	4.0297e-08 (rank : 33)	NC score	0.238960 (rank : 147)
Query Neighborhood Hits	219	Target Neighborhood Hits	690	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

MPDZ_HUMAN
θ value	4.0297e-08 (rank : 34)	NC score	0.625869 (rank : 20)
Query Neighborhood Hits	219	Target Neighborhood Hits	261	Shared Neighborhood Hits	179
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PTN13_HUMAN
θ value	4.0297e-08 (rank : 35)	NC score	0.378613 (rank : 103)
Query Neighborhood Hits	219	Target Neighborhood Hits	471	Shared Neighborhood Hits	170
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

USH1C_HUMAN
θ value	5.26297e-08 (rank : 36)	NC score	0.609755 (rank : 23)
Query Neighborhood Hits	219	Target Neighborhood Hits	327	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

MPDZ_MOUSE
θ value	6.87365e-08 (rank : 37)	NC score	0.624529 (rank : 21)
Query Neighborhood Hits	219	Target Neighborhood Hits	298	Shared Neighborhood Hits	178
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

WHRN_MOUSE
θ value	6.87365e-08 (rank : 38)	NC score	0.603813 (rank : 24)
Query Neighborhood Hits	219	Target Neighborhood Hits	412	Shared Neighborhood Hits	174
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PZRN3_MOUSE
θ value	8.97725e-08 (rank : 39)	NC score	0.505388 (rank : 65)
Query Neighborhood Hits	219	Target Neighborhood Hits	447	Shared Neighborhood Hits	147
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PTN13_MOUSE
θ value	1.53129e-07 (rank : 40)	NC score	0.371842 (rank : 105)
Query Neighborhood Hits	219	Target Neighborhood Hits	426	Shared Neighborhood Hits	174
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

LNX2_HUMAN
θ value	1.99992e-07 (rank : 41)	NC score	0.570373 (rank : 43)
Query Neighborhood Hits	219	Target Neighborhood Hits	389	Shared Neighborhood Hits	167
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

MPP6_HUMAN
θ value	2.61198e-07 (rank : 42)	NC score	0.474591 (rank : 78)
Query Neighborhood Hits	219	Target Neighborhood Hits	180	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

PDZ11_HUMAN
θ value	2.61198e-07 (rank : 43)	NC score	0.642921 (rank : 18)
Query Neighborhood Hits	219	Target Neighborhood Hits	160	Shared Neighborhood Hits	141
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	3.41135e-07 (rank : 44)	NC score	0.642343 (rank : 19)
Query Neighborhood Hits	219	Target Neighborhood Hits	154	Shared Neighborhood Hits	135
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD2_HUMAN
θ value	7.59969e-07 (rank : 45)	NC score	0.579490 (rank : 39)
Query Neighborhood Hits	219	Target Neighborhood Hits	772	Shared Neighborhood Hits	177
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

MPP6_MOUSE
θ value	1.29631e-06 (rank : 46)	NC score	0.469015 (rank : 79)
Query Neighborhood Hits	219	Target Neighborhood Hits	187	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

PZRN4_HUMAN
θ value	3.77169e-06 (rank : 47)	NC score	0.509606 (rank : 63)
Query Neighborhood Hits	219	Target Neighborhood Hits	438	Shared Neighborhood Hits	146
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

GRIP1_MOUSE
θ value	4.92598e-06 (rank : 48)	NC score	0.579722 (rank : 38)
Query Neighborhood Hits	219	Target Neighborhood Hits	241	Shared Neighborhood Hits	175
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

SNTG2_HUMAN
θ value	4.92598e-06 (rank : 49)	NC score	0.544249 (rank : 54)
Query Neighborhood Hits	219	Target Neighborhood Hits	191	Shared Neighborhood Hits	162
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

CAR10_MOUSE
θ value	6.43352e-06 (rank : 50)	NC score	0.216476 (rank : 154)
Query Neighborhood Hits	219	Target Neighborhood Hits	407	Shared Neighborhood Hits	23
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

MPP3_HUMAN
θ value	6.43352e-06 (rank : 51)	NC score	0.500766 (rank : 67)
Query Neighborhood Hits	219	Target Neighborhood Hits	171	Shared Neighborhood Hits	121
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

SNTB2_MOUSE
θ value	6.43352e-06 (rank : 52)	NC score	0.521396 (rank : 58)
Query Neighborhood Hits	219	Target Neighborhood Hits	181	Shared Neighborhood Hits	149
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

GRIP2_HUMAN
θ value	1.09739e-05 (rank : 53)	NC score	0.588205 (rank : 32)
Query Neighborhood Hits	219	Target Neighborhood Hits	256	Shared Neighborhood Hits	172
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

SNTG2_MOUSE
θ value	1.09739e-05 (rank : 54)	NC score	0.516053 (rank : 61)
Query Neighborhood Hits	219	Target Neighborhood Hits	176	Shared Neighborhood Hits	150
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTB2_HUMAN
θ value	1.43324e-05 (rank : 55)	NC score	0.520303 (rank : 59)
Query Neighborhood Hits	219	Target Neighborhood Hits	180	Shared Neighborhood Hits	150
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

LAP4_MOUSE
θ value	1.87187e-05 (rank : 56)	NC score	0.412736 (rank : 91)
Query Neighborhood Hits	219	Target Neighborhood Hits	590	Shared Neighborhood Hits	178
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

RPGF6_HUMAN
θ value	1.87187e-05 (rank : 57)	NC score	0.361822 (rank : 106)
Query Neighborhood Hits	219	Target Neighborhood Hits	266	Shared Neighborhood Hits	145
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GOPC_HUMAN
θ value	3.19293e-05 (rank : 58)	NC score	0.548636 (rank : 52)
Query Neighborhood Hits	219	Target Neighborhood Hits	377	Shared Neighborhood Hits	156
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	3.19293e-05 (rank : 59)	NC score	0.558340 (rank : 47)
Query Neighborhood Hits	219	Target Neighborhood Hits	323	Shared Neighborhood Hits	156
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

LAP4_HUMAN
θ value	3.19293e-05 (rank : 60)	NC score	0.417228 (rank : 88)
Query Neighborhood Hits	219	Target Neighborhood Hits	608	Shared Neighborhood Hits	180
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP2_HUMAN
θ value	4.1701e-05 (rank : 61)	NC score	0.239944 (rank : 145)
Query Neighborhood Hits	219	Target Neighborhood Hits	499	Shared Neighborhood Hits	106
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	4.1701e-05 (rank : 62)	NC score	0.231583 (rank : 150)
Query Neighborhood Hits	219	Target Neighborhood Hits	482	Shared Neighborhood Hits	104
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LIN7B_HUMAN
θ value	4.1701e-05 (rank : 63)	NC score	0.598129 (rank : 26)
Query Neighborhood Hits	219	Target Neighborhood Hits	200	Shared Neighborhood Hits	174
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

GRIP1_HUMAN
θ value	5.44631e-05 (rank : 64)	NC score	0.582518 (rank : 37)
Query Neighborhood Hits	219	Target Neighborhood Hits	231	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

IL16_HUMAN
θ value	5.44631e-05 (rank : 65)	NC score	0.561173 (rank : 46)
Query Neighborhood Hits	219	Target Neighborhood Hits	207	Shared Neighborhood Hits	136
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LIN7B_MOUSE
θ value	5.44631e-05 (rank : 66)	NC score	0.595950 (rank : 29)
Query Neighborhood Hits	219	Target Neighborhood Hits	200	Shared Neighborhood Hits	174
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

IL16_MOUSE
θ value	7.1131e-05 (rank : 67)	NC score	0.539849 (rank : 55)
Query Neighborhood Hits	219	Target Neighborhood Hits	189	Shared Neighborhood Hits	133
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LIN7A_HUMAN
θ value	7.1131e-05 (rank : 68)	NC score	0.588687 (rank : 30)
Query Neighborhood Hits	219	Target Neighborhood Hits	193	Shared Neighborhood Hits	171
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	7.1131e-05 (rank : 69)	NC score	0.588566 (rank : 31)
Query Neighborhood Hits	219	Target Neighborhood Hits	193	Shared Neighborhood Hits	171
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7C_HUMAN
θ value	7.1131e-05 (rank : 70)	NC score	0.596373 (rank : 27)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	172
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	7.1131e-05 (rank : 71)	NC score	0.596373 (rank : 28)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	172
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

CSKP_HUMAN
θ value	0.000121331 (rank : 72)	NC score	0.162105 (rank : 174)
Query Neighborhood Hits	219	Target Neighborhood Hits	1022	Shared Neighborhood Hits	110
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DVL1_HUMAN
θ value	0.000121331 (rank : 73)	NC score	0.408218 (rank : 94)
Query Neighborhood Hits	219	Target Neighborhood Hits	158	Shared Neighborhood Hits	115
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	0.000121331 (rank : 74)	NC score	0.404380 (rank : 95)
Query Neighborhood Hits	219	Target Neighborhood Hits	146	Shared Neighborhood Hits	114
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

PDZD7_HUMAN
θ value	0.000121331 (rank : 75)	NC score	0.600384 (rank : 25)
Query Neighborhood Hits	219	Target Neighborhood Hits	181	Shared Neighborhood Hits	159
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

DVL1L_HUMAN
θ value	0.000158464 (rank : 76)	NC score	0.397571 (rank : 98)
Query Neighborhood Hits	219	Target Neighborhood Hits	146	Shared Neighborhood Hits	111
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

LRRC7_HUMAN
θ value	0.000158464 (rank : 77)	NC score	0.248889 (rank : 141)
Query Neighborhood Hits	219	Target Neighborhood Hits	423	Shared Neighborhood Hits	112
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	0.000158464 (rank : 78)	NC score	0.248128 (rank : 142)
Query Neighborhood Hits	219	Target Neighborhood Hits	416	Shared Neighborhood Hits	112
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

USH1C_MOUSE
θ value	0.00020696 (rank : 79)	NC score	0.557484 (rank : 48)
Query Neighborhood Hits	219	Target Neighborhood Hits	557	Shared Neighborhood Hits	177
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

DVL3_HUMAN
θ value	0.000270298 (rank : 80)	NC score	0.410278 (rank : 92)
Query Neighborhood Hits	219	Target Neighborhood Hits	194	Shared Neighborhood Hits	112
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.000270298 (rank : 81)	NC score	0.410069 (rank : 93)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	112
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

RPGF2_HUMAN
θ value	0.000270298 (rank : 82)	NC score	0.317013 (rank : 119)
Query Neighborhood Hits	219	Target Neighborhood Hits	242	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

DVL2_HUMAN
θ value	0.00035302 (rank : 83)	NC score	0.391762 (rank : 99)
Query Neighborhood Hits	219	Target Neighborhood Hits	223	Shared Neighborhood Hits	113
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

PDZK4_HUMAN
θ value	0.00035302 (rank : 84)	NC score	0.414862 (rank : 90)
Query Neighborhood Hits	219	Target Neighborhood Hits	165	Shared Neighborhood Hits	115
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

DVL2_MOUSE
θ value	0.000602161 (rank : 85)	NC score	0.391173 (rank : 100)
Query Neighborhood Hits	219	Target Neighborhood Hits	233	Shared Neighborhood Hits	112
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

SNTG1_HUMAN
θ value	0.000602161 (rank : 86)	NC score	0.494459 (rank : 69)
Query Neighborhood Hits	219	Target Neighborhood Hits	181	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
θ value	0.000602161 (rank : 87)	NC score	0.494308 (rank : 70)
Query Neighborhood Hits	219	Target Neighborhood Hits	179	Shared Neighborhood Hits	153
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

STXB4_MOUSE
θ value	0.000602161 (rank : 88)	NC score	0.314406 (rank : 120)
Query Neighborhood Hits	219	Target Neighborhood Hits	629	Shared Neighborhood Hits	97
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MPP3_MOUSE
θ value	0.000786445 (rank : 89)	NC score	0.493949 (rank : 71)
Query Neighborhood Hits	219	Target Neighborhood Hits	165	Shared Neighborhood Hits	120
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

ARHGB_HUMAN
θ value	0.00102713 (rank : 90)	NC score	0.275722 (rank : 127)
Query Neighborhood Hits	219	Target Neighborhood Hits	375	Shared Neighborhood Hits	153
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SNTA1_HUMAN
θ value	0.00134147 (rank : 91)	NC score	0.505355 (rank : 66)
Query Neighborhood Hits	219	Target Neighborhood Hits	186	Shared Neighborhood Hits	153
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

GRB2_MOUSE
θ value	0.00175202 (rank : 92)	NC score	0.086494 (rank : 192)
Query Neighborhood Hits	219	Target Neighborhood Hits	312	Shared Neighborhood Hits	28
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

PDZK4_MOUSE
θ value	0.00175202 (rank : 93)	NC score	0.415188 (rank : 89)
Query Neighborhood Hits	219	Target Neighborhood Hits	165	Shared Neighborhood Hits	123
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

SNTA1_MOUSE
θ value	0.00175202 (rank : 94)	NC score	0.499589 (rank : 68)
Query Neighborhood Hits	219	Target Neighborhood Hits	170	Shared Neighborhood Hits	149
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

TIAM1_HUMAN
θ value	0.00175202 (rank : 95)	NC score	0.099532 (rank : 190)
Query Neighborhood Hits	219	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

EM55_HUMAN
θ value	0.00228821 (rank : 96)	NC score	0.477105 (rank : 77)
Query Neighborhood Hits	219	Target Neighborhood Hits	228	Shared Neighborhood Hits	112
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SNTB1_HUMAN
θ value	0.00228821 (rank : 97)	NC score	0.490684 (rank : 72)
Query Neighborhood Hits	219	Target Neighborhood Hits	157	Shared Neighborhood Hits	140
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	0.00228821 (rank : 98)	NC score	0.488978 (rank : 73)
Query Neighborhood Hits	219	Target Neighborhood Hits	160	Shared Neighborhood Hits	138
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

GRB2_HUMAN
θ value	0.00298849 (rank : 99)	NC score	0.085623 (rank : 193)
Query Neighborhood Hits	219	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

PDZD1_HUMAN
θ value	0.00298849 (rank : 100)	NC score	0.513306 (rank : 62)
Query Neighborhood Hits	219	Target Neighborhood Hits	190	Shared Neighborhood Hits	149
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

STXB4_HUMAN
θ value	0.00298849 (rank : 101)	NC score	0.323913 (rank : 115)
Query Neighborhood Hits	219	Target Neighborhood Hits	616	Shared Neighborhood Hits	104
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SYNP2_MOUSE
θ value	0.00298849 (rank : 102)	NC score	0.256542 (rank : 134)
Query Neighborhood Hits	219	Target Neighborhood Hits	252	Shared Neighborhood Hits	120
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

CAR10_HUMAN
θ value	0.00509761 (rank : 103)	NC score	0.174573 (rank : 168)
Query Neighborhood Hits	219	Target Neighborhood Hits	569	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

RGS12_HUMAN
θ value	0.00509761 (rank : 104)	NC score	0.239807 (rank : 146)
Query Neighborhood Hits	219	Target Neighborhood Hits	333	Shared Neighborhood Hits	132
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

AFAD_HUMAN
θ value	0.00665767 (rank : 105)	NC score	0.375565 (rank : 104)
Query Neighborhood Hits	219	Target Neighborhood Hits	689	Shared Neighborhood Hits	140
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

LMO7_HUMAN
θ value	0.00665767 (rank : 106)	NC score	0.148714 (rank : 179)
Query Neighborhood Hits	219	Target Neighborhood Hits	507	Shared Neighborhood Hits	58
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

NHRF2_HUMAN
θ value	0.00665767 (rank : 107)	NC score	0.460592 (rank : 83)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	161
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	0.00665767 (rank : 108)	NC score	0.448395 (rank : 84)
Query Neighborhood Hits	219	Target Neighborhood Hits	194	Shared Neighborhood Hits	162
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

SDCB1_HUMAN
θ value	0.00665767 (rank : 109)	NC score	0.378853 (rank : 102)
Query Neighborhood Hits	219	Target Neighborhood Hits	150	Shared Neighborhood Hits	129
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	0.00665767 (rank : 110)	NC score	0.381427 (rank : 101)
Query Neighborhood Hits	219	Target Neighborhood Hits	144	Shared Neighborhood Hits	128
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

NEB1_HUMAN
θ value	0.00869519 (rank : 111)	NC score	0.351528 (rank : 109)
Query Neighborhood Hits	219	Target Neighborhood Hits	829	Shared Neighborhood Hits	123
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PARD3_HUMAN
θ value	0.00869519 (rank : 112)	NC score	0.539225 (rank : 56)
Query Neighborhood Hits	219	Target Neighborhood Hits	312	Shared Neighborhood Hits	152
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
θ value	0.00869519 (rank : 113)	NC score	0.536290 (rank : 57)
Query Neighborhood Hits	219	Target Neighborhood Hits	290	Shared Neighborhood Hits	149
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

RIMS2_HUMAN
θ value	0.00869519 (rank : 114)	NC score	0.183331 (rank : 165)
Query Neighborhood Hits	219	Target Neighborhood Hits	342	Shared Neighborhood Hits	95
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	0.00869519 (rank : 115)	NC score	0.183413 (rank : 164)
Query Neighborhood Hits	219	Target Neighborhood Hits	376	Shared Neighborhood Hits	96
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

EM55_MOUSE
θ value	0.0113563 (rank : 116)	NC score	0.483397 (rank : 75)
Query Neighborhood Hits	219	Target Neighborhood Hits	221	Shared Neighborhood Hits	110
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

CSKP_MOUSE
θ value	0.0148317 (rank : 117)	NC score	0.150960 (rank : 178)
Query Neighborhood Hits	219	Target Neighborhood Hits	1027	Shared Neighborhood Hits	111
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

PRAX_HUMAN
θ value	0.0148317 (rank : 118)	NC score	0.151361 (rank : 177)
Query Neighborhood Hits	219	Target Neighborhood Hits	215	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PTN4_HUMAN
θ value	0.0148317 (rank : 119)	NC score	0.139539 (rank : 182)
Query Neighborhood Hits	219	Target Neighborhood Hits	303	Shared Neighborhood Hits	111
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

SYJ2B_HUMAN
θ value	0.0148317 (rank : 120)	NC score	0.677362 (rank : 15)
Query Neighborhood Hits	219	Target Neighborhood Hits	162	Shared Neighborhood Hits	147
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

APBA3_MOUSE
θ value	0.0193708 (rank : 121)	NC score	0.326833 (rank : 114)
Query Neighborhood Hits	219	Target Neighborhood Hits	174	Shared Neighborhood Hits	119
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PRAX_MOUSE
θ value	0.0193708 (rank : 122)	NC score	0.176794 (rank : 167)
Query Neighborhood Hits	219	Target Neighborhood Hits	199	Shared Neighborhood Hits	44
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

K1849_MOUSE
θ value	0.0252991 (rank : 123)	NC score	0.401957 (rank : 96)
Query Neighborhood Hits	219	Target Neighborhood Hits	335	Shared Neighborhood Hits	140
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

NEB2_HUMAN
θ value	0.0252991 (rank : 124)	NC score	0.336961 (rank : 111)
Query Neighborhood Hits	219	Target Neighborhood Hits	883	Shared Neighborhood Hits	113
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	0.0252991 (rank : 125)	NC score	0.332841 (rank : 113)
Query Neighborhood Hits	219	Target Neighborhood Hits	889	Shared Neighborhood Hits	114
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

TX1B3_HUMAN
θ value	0.0252991 (rank : 126)	NC score	0.554659 (rank : 50)
Query Neighborhood Hits	219	Target Neighborhood Hits	161	Shared Neighborhood Hits	146
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.0252991 (rank : 127)	NC score	0.552759 (rank : 51)
Query Neighborhood Hits	219	Target Neighborhood Hits	158	Shared Neighborhood Hits	143
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

PAR3L_HUMAN
θ value	0.0330416 (rank : 128)	NC score	0.546935 (rank : 53)
Query Neighborhood Hits	219	Target Neighborhood Hits	297	Shared Neighborhood Hits	143
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PDLI5_HUMAN
θ value	0.0330416 (rank : 129)	NC score	0.172131 (rank : 169)
Query Neighborhood Hits	219	Target Neighborhood Hits	322	Shared Neighborhood Hits	112
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDZD3_HUMAN
θ value	0.0330416 (rank : 130)	NC score	0.464778 (rank : 81)
Query Neighborhood Hits	219	Target Neighborhood Hits	180	Shared Neighborhood Hits	153
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PDZD1_MOUSE
θ value	0.0563607 (rank : 131)	NC score	0.519054 (rank : 60)
Query Neighborhood Hits	219	Target Neighborhood Hits	191	Shared Neighborhood Hits	152
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

SYNP2_HUMAN
θ value	0.0736092 (rank : 132)	NC score	0.209271 (rank : 156)
Query Neighborhood Hits	219	Target Neighborhood Hits	323	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

ARHGC_HUMAN
θ value	0.0961366 (rank : 133)	NC score	0.254494 (rank : 137)
Query Neighborhood Hits	219	Target Neighborhood Hits	351	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LDB3_HUMAN
θ value	0.0961366 (rank : 134)	NC score	0.162744 (rank : 173)
Query Neighborhood Hits	219	Target Neighborhood Hits	497	Shared Neighborhood Hits	104
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	0.0961366 (rank : 135)	NC score	0.164182 (rank : 172)
Query Neighborhood Hits	219	Target Neighborhood Hits	510	Shared Neighborhood Hits	100
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

NOS1_HUMAN
θ value	0.0961366 (rank : 136)	NC score	0.253194 (rank : 138)
Query Neighborhood Hits	219	Target Neighborhood Hits	218	Shared Neighborhood Hits	131
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PCLO_MOUSE
θ value	0.0961366 (rank : 137)	NC score	0.160731 (rank : 175)
Query Neighborhood Hits	219	Target Neighborhood Hits	2275	Shared Neighborhood Hits	133
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDLI4_MOUSE
θ value	0.0961366 (rank : 138)	NC score	0.219209 (rank : 153)
Query Neighborhood Hits	219	Target Neighborhood Hits	233	Shared Neighborhood Hits	107
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

SDCB2_MOUSE
θ value	0.0961366 (rank : 139)	NC score	0.320885 (rank : 116)
Query Neighborhood Hits	219	Target Neighborhood Hits	118	Shared Neighborhood Hits	102
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

ARHGC_MOUSE
θ value	0.125558 (rank : 140)	NC score	0.249873 (rank : 139)
Query Neighborhood Hits	219	Target Neighborhood Hits	344	Shared Neighborhood Hits	140
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

IRS2_MOUSE
θ value	0.125558 (rank : 141)	NC score	0.026466 (rank : 235)
Query Neighborhood Hits	219	Target Neighborhood Hits	248	Shared Neighborhood Hits	15
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

PDLI2_HUMAN
θ value	0.125558 (rank : 142)	NC score	0.334071 (rank : 112)
Query Neighborhood Hits	219	Target Neighborhood Hits	245	Shared Neighborhood Hits	124
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI5_MOUSE
θ value	0.125558 (rank : 143)	NC score	0.164978 (rank : 171)
Query Neighborhood Hits	219	Target Neighborhood Hits	287	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

KI20A_MOUSE
θ value	0.163984 (rank : 144)	NC score	0.011526 (rank : 249)
Query Neighborhood Hits	219	Target Neighborhood Hits	310	Shared Neighborhood Hits	6
SwissProt Accessions	P97329, Q542M4	Gene names	Kif20a, Rab6kifl
Domain Architecture
Description	Kinesin family member 20A (Rabkinesin-6) (Rab6-interacting kinesin- like protein) (Kinesin-like protein 174).

NOS1_MOUSE
θ value	0.163984 (rank : 145)	NC score	0.206689 (rank : 157)
Query Neighborhood Hits	219	Target Neighborhood Hits	155	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDZD3_MOUSE
θ value	0.163984 (rank : 146)	NC score	0.418722 (rank : 87)
Query Neighborhood Hits	219	Target Neighborhood Hits	171	Shared Neighborhood Hits	150
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

NHERF_MOUSE
θ value	0.279714 (rank : 147)	NC score	0.468559 (rank : 80)
Query Neighborhood Hits	219	Target Neighborhood Hits	195	Shared Neighborhood Hits	152
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDLI2_MOUSE
θ value	0.279714 (rank : 148)	NC score	0.305213 (rank : 125)
Query Neighborhood Hits	219	Target Neighborhood Hits	220	Shared Neighborhood Hits	118
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

SDCB2_HUMAN
θ value	0.279714 (rank : 149)	NC score	0.305758 (rank : 124)
Query Neighborhood Hits	219	Target Neighborhood Hits	121	Shared Neighborhood Hits	112
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SYP2L_HUMAN
θ value	0.279714 (rank : 150)	NC score	0.289647 (rank : 126)
Query Neighborhood Hits	219	Target Neighborhood Hits	400	Shared Neighborhood Hits	112
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

K1849_HUMAN
θ value	0.365318 (rank : 151)	NC score	0.401102 (rank : 97)
Query Neighborhood Hits	219	Target Neighborhood Hits	220	Shared Neighborhood Hits	131
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MAST3_HUMAN
θ value	0.365318 (rank : 152)	NC score	0.040237 (rank : 229)
Query Neighborhood Hits	219	Target Neighborhood Hits	1128	Shared Neighborhood Hits	115
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MPP4_HUMAN
θ value	0.365318 (rank : 153)	NC score	0.462155 (rank : 82)
Query Neighborhood Hits	219	Target Neighborhood Hits	205	Shared Neighborhood Hits	130
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

RHPN1_MOUSE
θ value	0.365318 (rank : 154)	NC score	0.273470 (rank : 129)
Query Neighborhood Hits	219	Target Neighborhood Hits	154	Shared Neighborhood Hits	128
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

TIAM1_MOUSE
θ value	0.365318 (rank : 155)	NC score	0.075497 (rank : 201)
Query Neighborhood Hits	219	Target Neighborhood Hits	205	Shared Neighborhood Hits	43
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

APBA1_HUMAN
θ value	0.47712 (rank : 156)	NC score	0.345289 (rank : 110)
Query Neighborhood Hits	219	Target Neighborhood Hits	325	Shared Neighborhood Hits	138
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

MAST2_HUMAN
θ value	0.47712 (rank : 157)	NC score	0.045270 (rank : 227)
Query Neighborhood Hits	219	Target Neighborhood Hits	1189	Shared Neighborhood Hits	116
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	0.47712 (rank : 158)	NC score	0.043570 (rank : 228)
Query Neighborhood Hits	219	Target Neighborhood Hits	1110	Shared Neighborhood Hits	116
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

NHERF_HUMAN
θ value	0.47712 (rank : 159)	NC score	0.448125 (rank : 85)
Query Neighborhood Hits	219	Target Neighborhood Hits	190	Shared Neighborhood Hits	152
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PSCBP_HUMAN
θ value	0.47712 (rank : 160)	NC score	0.230271 (rank : 151)
Query Neighborhood Hits	219	Target Neighborhood Hits	123	Shared Neighborhood Hits	109
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PTN3_HUMAN
θ value	0.47712 (rank : 161)	NC score	0.124743 (rank : 184)
Query Neighborhood Hits	219	Target Neighborhood Hits	258	Shared Neighborhood Hits	110
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

APBA2_HUMAN
θ value	0.62314 (rank : 162)	NC score	0.317309 (rank : 117)
Query Neighborhood Hits	219	Target Neighborhood Hits	220	Shared Neighborhood Hits	135
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.62314 (rank : 163)	NC score	0.317016 (rank : 118)
Query Neighborhood Hits	219	Target Neighborhood Hits	219	Shared Neighborhood Hits	135
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

MAST4_HUMAN
θ value	0.62314 (rank : 164)	NC score	0.047382 (rank : 226)
Query Neighborhood Hits	219	Target Neighborhood Hits	1804	Shared Neighborhood Hits	129
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MK06_MOUSE
θ value	0.62314 (rank : 165)	NC score	0.000569 (rank : 264)
Query Neighborhood Hits	219	Target Neighborhood Hits	818	Shared Neighborhood Hits	12
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

ABTAP_HUMAN
θ value	0.813845 (rank : 166)	NC score	0.014778 (rank : 245)
Query Neighborhood Hits	219	Target Neighborhood Hits	290	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

MPP4_MOUSE
θ value	0.813845 (rank : 167)	NC score	0.439094 (rank : 86)
Query Neighborhood Hits	219	Target Neighborhood Hits	188	Shared Neighborhood Hits	113
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PDLI1_HUMAN
θ value	0.813845 (rank : 168)	NC score	0.185685 (rank : 163)
Query Neighborhood Hits	219	Target Neighborhood Hits	242	Shared Neighborhood Hits	95
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

SYP2L_MOUSE
θ value	0.813845 (rank : 169)	NC score	0.219365 (rank : 152)
Query Neighborhood Hits	219	Target Neighborhood Hits	289	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

NGAP_HUMAN
θ value	1.06291 (rank : 170)	NC score	0.012476 (rank : 247)
Query Neighborhood Hits	219	Target Neighborhood Hits	517	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

SHAN1_HUMAN
θ value	1.06291 (rank : 171)	NC score	0.123800 (rank : 186)
Query Neighborhood Hits	219	Target Neighborhood Hits	1041	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

APBA3_HUMAN
θ value	1.38821 (rank : 172)	NC score	0.306623 (rank : 122)
Query Neighborhood Hits	219	Target Neighborhood Hits	201	Shared Neighborhood Hits	127
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

RGS3_HUMAN
θ value	1.38821 (rank : 173)	NC score	0.057173 (rank : 218)
Query Neighborhood Hits	219	Target Neighborhood Hits	1375	Shared Neighborhood Hits	75
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ZBT37_HUMAN
θ value	1.38821 (rank : 174)	NC score	-0.005901 (rank : 265)
Query Neighborhood Hits	219	Target Neighborhood Hits	815	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TC79, Q5TC80, Q96M87, Q9BQ88	Gene names	ZBTB37
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 37.

HTRA1_HUMAN
θ value	1.81305 (rank : 175)	NC score	0.061732 (rank : 213)
Query Neighborhood Hits	219	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA3_HUMAN
θ value	1.81305 (rank : 176)	NC score	0.094899 (rank : 191)
Query Neighborhood Hits	219	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	1.81305 (rank : 177)	NC score	0.105217 (rank : 189)
Query Neighborhood Hits	219	Target Neighborhood Hits	156	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

NMDE4_HUMAN
θ value	1.81305 (rank : 178)	NC score	0.008076 (rank : 256)
Query Neighborhood Hits	219	Target Neighborhood Hits	133	Shared Neighborhood Hits	5
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

NMDE4_MOUSE
θ value	1.81305 (rank : 179)	NC score	0.008760 (rank : 254)
Query Neighborhood Hits	219	Target Neighborhood Hits	158	Shared Neighborhood Hits	8
SwissProt Accessions	Q03391	Gene names	Grin2d
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D).

GGN_MOUSE
θ value	2.36792 (rank : 180)	NC score	0.022214 (rank : 238)
Query Neighborhood Hits	219	Target Neighborhood Hits	311	Shared Neighborhood Hits	12
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GYS1_MOUSE
θ value	2.36792 (rank : 181)	NC score	0.018920 (rank : 239)
Query Neighborhood Hits	219	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1E4	Gene names	Gys1, Gys
Domain Architecture
Description	Glycogen [starch] synthase, muscle (EC 2.4.1.11).

GYS3_MOUSE
θ value	2.36792 (rank : 182)	NC score	0.018872 (rank : 240)
Query Neighborhood Hits	219	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	P54859	Gene names	Gys3
Domain Architecture
Description	Glycogen [starch] synthase, brain (EC 2.4.1.11).

HTRA1_MOUSE
θ value	2.36792 (rank : 183)	NC score	0.060582 (rank : 214)
Query Neighborhood Hits	219	Target Neighborhood Hits	140	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

MAST1_MOUSE
θ value	2.36792 (rank : 184)	NC score	0.039539 (rank : 230)
Query Neighborhood Hits	219	Target Neighborhood Hits	1123	Shared Neighborhood Hits	114
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PDLI3_HUMAN
θ value	2.36792 (rank : 185)	NC score	0.216448 (rank : 155)
Query Neighborhood Hits	219	Target Neighborhood Hits	199	Shared Neighborhood Hits	105
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	2.36792 (rank : 186)	NC score	0.194070 (rank : 160)
Query Neighborhood Hits	219	Target Neighborhood Hits	245	Shared Neighborhood Hits	107
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

RGS3_MOUSE
θ value	2.36792 (rank : 187)	NC score	0.052868 (rank : 224)
Query Neighborhood Hits	219	Target Neighborhood Hits	1621	Shared Neighborhood Hits	86
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

INCE_MOUSE
θ value	3.0926 (rank : 188)	NC score	0.009895 (rank : 252)
Query Neighborhood Hits	219	Target Neighborhood Hits	903	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

LIMA1_MOUSE
θ value	3.0926 (rank : 189)	NC score	0.018341 (rank : 242)
Query Neighborhood Hits	219	Target Neighborhood Hits	298	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ERG0, Q9ERG1	Gene names	Lima1, D15Ertd366e, Eplin
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN).

LIMK2_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.025753 (rank : 236)
Query Neighborhood Hits	219	Target Neighborhood Hits	986	Shared Neighborhood Hits	69
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

PDLI7_HUMAN
θ value	4.03905 (rank : 191)	NC score	0.146555 (rank : 181)
Query Neighborhood Hits	219	Target Neighborhood Hits	547	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PICK1_MOUSE
θ value	4.03905 (rank : 192)	NC score	0.308405 (rank : 121)
Query Neighborhood Hits	219	Target Neighborhood Hits	131	Shared Neighborhood Hits	110
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SHAN2_HUMAN
θ value	4.03905 (rank : 193)	NC score	0.192183 (rank : 161)
Query Neighborhood Hits	219	Target Neighborhood Hits	346	Shared Neighborhood Hits	117
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

VILI_MOUSE
θ value	4.03905 (rank : 194)	NC score	0.006151 (rank : 259)
Query Neighborhood Hits	219	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q62468, Q91WH4	Gene names	Vil1, Vil
Domain Architecture
Description	Villin-1.

ZFY16_HUMAN
θ value	4.03905 (rank : 195)	NC score	0.006627 (rank : 258)
Query Neighborhood Hits	219	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

CO4A2_MOUSE
θ value	5.27518 (rank : 196)	NC score	0.001421 (rank : 262)
Query Neighborhood Hits	219	Target Neighborhood Hits	492	Shared Neighborhood Hits	17
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

FILA_HUMAN
θ value	5.27518 (rank : 197)	NC score	0.018190 (rank : 243)
Query Neighborhood Hits	219	Target Neighborhood Hits	685	Shared Neighborhood Hits	23
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

HRX_HUMAN
θ value	5.27518 (rank : 198)	NC score	0.010249 (rank : 251)
Query Neighborhood Hits	219	Target Neighborhood Hits	825	Shared Neighborhood Hits	25
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

LETM1_MOUSE
θ value	5.27518 (rank : 199)	NC score	0.006899 (rank : 257)
Query Neighborhood Hits	219	Target Neighborhood Hits	240	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2I0, Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5	Gene names	Letm1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

LIMK2_MOUSE
θ value	5.27518 (rank : 200)	NC score	0.027851 (rank : 234)
Query Neighborhood Hits	219	Target Neighborhood Hits	998	Shared Neighborhood Hits	67
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MAST1_HUMAN
θ value	5.27518 (rank : 201)	NC score	0.038094 (rank : 231)
Query Neighborhood Hits	219	Target Neighborhood Hits	1146	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PDLI7_MOUSE
θ value	5.27518 (rank : 202)	NC score	0.128254 (rank : 183)
Query Neighborhood Hits	219	Target Neighborhood Hits	279	Shared Neighborhood Hits	97
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PICK1_HUMAN
θ value	5.27518 (rank : 203)	NC score	0.306091 (rank : 123)
Query Neighborhood Hits	219	Target Neighborhood Hits	132	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

RNZ1_HUMAN
θ value	5.27518 (rank : 204)	NC score	0.010760 (rank : 250)
Query Neighborhood Hits	219	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H777, Q9NS99	Gene names	ELAC1, D29
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1) (Deleted in Ma29).

SON_MOUSE
θ value	5.27518 (rank : 205)	NC score	0.008596 (rank : 255)
Query Neighborhood Hits	219	Target Neighborhood Hits	957	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

IGLL1_MOUSE
θ value	6.88961 (rank : 206)	NC score	0.009502 (rank : 253)
Query Neighborhood Hits	219	Target Neighborhood Hits	196	Shared Neighborhood Hits	3
SwissProt Accessions	P20764, Q5W1K3	Gene names	Igll1, Igl-5
Domain Architecture	No domain graphic available
Description	Immunoglobulin lambda-like polypeptide 1 precursor (Ig lambda-5) (CD179b antigen).

OSTF1_HUMAN
θ value	6.88961 (rank : 207)	NC score	0.036478 (rank : 232)
Query Neighborhood Hits	219	Target Neighborhood Hits	466	Shared Neighborhood Hits	27
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

RHPN1_HUMAN
θ value	6.88961 (rank : 208)	NC score	0.247918 (rank : 143)
Query Neighborhood Hits	219	Target Neighborhood Hits	158	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SRRM2_HUMAN
θ value	6.88961 (rank : 209)	NC score	0.029303 (rank : 233)
Query Neighborhood Hits	219	Target Neighborhood Hits	1296	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

VILI_HUMAN
θ value	6.88961 (rank : 210)	NC score	0.005341 (rank : 260)
Query Neighborhood Hits	219	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	P09327	Gene names	VIL1, VIL
Domain Architecture
Description	Villin-1.

CE005_HUMAN
θ value	8.99809 (rank : 211)	NC score	0.001087 (rank : 263)
Query Neighborhood Hits	219	Target Neighborhood Hits	213	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

DNM3A_HUMAN
θ value	8.99809 (rank : 212)	NC score	0.004034 (rank : 261)
Query Neighborhood Hits	219	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

DSPP_HUMAN
θ value	8.99809 (rank : 213)	NC score	0.018490 (rank : 241)
Query Neighborhood Hits	219	Target Neighborhood Hits	645	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

GYS1_HUMAN
θ value	8.99809 (rank : 214)	NC score	0.015929 (rank : 244)
Query Neighborhood Hits	219	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	P13807	Gene names	GYS1, GYS
Domain Architecture
Description	Glycogen [starch] synthase, muscle (EC 2.4.1.11).

IWS1_HUMAN
θ value	8.99809 (rank : 215)	NC score	0.023860 (rank : 237)
Query Neighborhood Hits	219	Target Neighborhood Hits	1241	Shared Neighborhood Hits	29
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LIMA1_HUMAN
θ value	8.99809 (rank : 216)	NC score	0.013689 (rank : 246)
Query Neighborhood Hits	219	Target Neighborhood Hits	309	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UHB6, Q2TAN7, Q9BVF2, Q9H8J1, Q9HBN5, Q9NX96, Q9NXC3, Q9NXU6, Q9P0H8, Q9UHB5	Gene names	LIMA1, EPLIN, SREBP3
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm).

PDLI3_MOUSE
θ value	8.99809 (rank : 217)	NC score	0.199488 (rank : 158)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	101
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PSCBP_MOUSE
θ value	8.99809 (rank : 218)	NC score	0.236176 (rank : 148)
Query Neighborhood Hits	219	Target Neighborhood Hits	118	Shared Neighborhood Hits	107
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SAPS1_HUMAN
θ value	8.99809 (rank : 219)	NC score	0.011714 (rank : 248)
Query Neighborhood Hits	219	Target Neighborhood Hits	704	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

APXL_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.194301 (rank : 159)
Query Neighborhood Hits	219	Target Neighborhood Hits	553	Shared Neighborhood Hits	94
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CACB1_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.078416 (rank : 198)
Query Neighborhood Hits	219	Target Neighborhood Hits	44	Shared Neighborhood Hits	21
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB1_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.082221 (rank : 195)
Query Neighborhood Hits	219	Target Neighborhood Hits	46	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.056966 (rank : 219)
Query Neighborhood Hits	219	Target Neighborhood Hits	99	Shared Neighborhood Hits	19
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

CACB2_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.051325 (rank : 225)
Query Neighborhood Hits	219	Target Neighborhood Hits	94	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CC27, Q8C5J5, Q9CTQ6	Gene names	Cacnb2, Cacnlb2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).

CACB3_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.073784 (rank : 203)
Query Neighborhood Hits	219	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CACB3_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.073340 (rank : 204)
Query Neighborhood Hits	219	Target Neighborhood Hits	48	Shared Neighborhood Hits	17
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

CACB4_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.076203 (rank : 200)
Query Neighborhood Hits	219	Target Neighborhood Hits	47	Shared Neighborhood Hits	18
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CACB4_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.073931 (rank : 202)
Query Neighborhood Hits	219	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CARD9_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.058037 (rank : 216)
Query Neighborhood Hits	219	Target Neighborhood Hits	602	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CNKR2_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.078375 (rank : 199)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.078445 (rank : 197)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	46
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRKL_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.055729 (rank : 221)
Query Neighborhood Hits	219	Target Neighborhood Hits	313	Shared Neighborhood Hits	26
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.057645 (rank : 217)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.082932 (rank : 194)
Query Neighborhood Hits	219	Target Neighborhood Hits	308	Shared Neighborhood Hits	27
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.081710 (rank : 196)
Query Neighborhood Hits	219	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GIPC1_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.147462 (rank : 180)
Query Neighborhood Hits	219	Target Neighborhood Hits	91	Shared Neighborhood Hits	77
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

GIPC1_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.154100 (rank : 176)
Query Neighborhood Hits	219	Target Neighborhood Hits	92	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GIPC2_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.110851 (rank : 187)
Query Neighborhood Hits	219	Target Neighborhood Hits	93	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GIPC2_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.063942 (rank : 206)
Query Neighborhood Hits	219	Target Neighborhood Hits	71	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GIPC3_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.061772 (rank : 212)
Query Neighborhood Hits	219	Target Neighborhood Hits	52	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.062095 (rank : 211)
Query Neighborhood Hits	219	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

GRASP_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.248961 (rank : 140)
Query Neighborhood Hits	219	Target Neighborhood Hits	147	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.245002 (rank : 144)
Query Neighborhood Hits	219	Target Neighborhood Hits	131	Shared Neighborhood Hits	114
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

KGUA_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.354016 (rank : 108)
Query Neighborhood Hits	219	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.359757 (rank : 107)
Query Neighborhood Hits	219	Target Neighborhood Hits	45	Shared Neighborhood Hits	30
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

NPHP1_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.059643 (rank : 215)
Query Neighborhood Hits	219	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PAR6A_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.256180 (rank : 136)
Query Neighborhood Hits	219	Target Neighborhood Hits	119	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.256400 (rank : 135)
Query Neighborhood Hits	219	Target Neighborhood Hits	115	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6B_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.271460 (rank : 130)
Query Neighborhood Hits	219	Target Neighborhood Hits	126	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.274121 (rank : 128)
Query Neighborhood Hits	219	Target Neighborhood Hits	128	Shared Neighborhood Hits	111
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.267734 (rank : 131)
Query Neighborhood Hits	219	Target Neighborhood Hits	159	Shared Neighborhood Hits	108
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.266976 (rank : 132)
Query Neighborhood Hits	219	Target Neighborhood Hits	121	Shared Neighborhood Hits	105
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PDLI1_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.177881 (rank : 166)
Query Neighborhood Hits	219	Target Neighborhood Hits	213	Shared Neighborhood Hits	95
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDZD6_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.124326 (rank : 185)
Query Neighborhood Hits	219	Target Neighborhood Hits	81	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PDZD8_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.108724 (rank : 188)
Query Neighborhood Hits	219	Target Neighborhood Hits	185	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

RIMS1_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.189859 (rank : 162)
Query Neighborhood Hits	219	Target Neighborhood Hits	437	Shared Neighborhood Hits	115
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RNF41_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.062101 (rank : 210)
Query Neighborhood Hits	219	Target Neighborhood Hits	226	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.062207 (rank : 209)
Query Neighborhood Hits	219	Target Neighborhood Hits	224	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

SAV1_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.053847 (rank : 223)
Query Neighborhood Hits	219	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.053881 (rank : 222)
Query Neighborhood Hits	219	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SHAN2_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.168922 (rank : 170)
Query Neighborhood Hits	219	Target Neighborhood Hits	446	Shared Neighborhood Hits	117
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

STAM1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.063529 (rank : 208)
Query Neighborhood Hits	219	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.072347 (rank : 205)
Query Neighborhood Hits	219	Target Neighborhood Hits	273	Shared Neighborhood Hits	27
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.056096 (rank : 220)
Query Neighborhood Hits	219	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.063840 (rank : 207)
Query Neighborhood Hits	219	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

Hits sorted by NC score

ZO3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	219	Target Neighborhood Hits	219	Shared Neighborhood Hits	219
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
NC score	0.987504 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	219	Target Neighborhood Hits	224	Shared Neighborhood Hits	185
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO2_MOUSE
NC score	0.948925 (rank : 3)	θ value	1.20145e-153 (rank : 5)
Query Neighborhood Hits	219	Target Neighborhood Hits	296	Shared Neighborhood Hits	168
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_HUMAN
NC score	0.946385 (rank : 4)	θ value	6.59259e-152 (rank : 6)
Query Neighborhood Hits	219	Target Neighborhood Hits	289	Shared Neighborhood Hits	167
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO1_MOUSE
NC score	0.919726 (rank : 5)	θ value	9.45368e-175 (rank : 3)
Query Neighborhood Hits	219	Target Neighborhood Hits	453	Shared Neighborhood Hits	183
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_HUMAN
NC score	0.916742 (rank : 6)	θ value	3.97187e-173 (rank : 4)
Query Neighborhood Hits	219	Target Neighborhood Hits	474	Shared Neighborhood Hits	181
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

DLG2_HUMAN
NC score	0.776409 (rank : 7)	θ value	4.88048e-38 (rank : 7)
Query Neighborhood Hits	219	Target Neighborhood Hits	279	Shared Neighborhood Hits	171
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG4_MOUSE
NC score	0.776251 (rank : 8)	θ value	3.17079e-29 (rank : 13)
Query Neighborhood Hits	219	Target Neighborhood Hits	282	Shared Neighborhood Hits	176
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG2_MOUSE
NC score	0.776156 (rank : 9)	θ value	4.568e-36 (rank : 8)
Query Neighborhood Hits	219	Target Neighborhood Hits	271	Shared Neighborhood Hits	169
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG4_HUMAN
NC score	0.775618 (rank : 10)	θ value	2.42779e-29 (rank : 12)
Query Neighborhood Hits	219	Target Neighborhood Hits	286	Shared Neighborhood Hits	176
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG3_HUMAN
NC score	0.773024 (rank : 11)	θ value	5.77852e-31 (rank : 10)
Query Neighborhood Hits	219	Target Neighborhood Hits	269	Shared Neighborhood Hits	172
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
NC score	0.771774 (rank : 12)	θ value	8.3442e-30 (rank : 11)
Query Neighborhood Hits	219	Target Neighborhood Hits	274	Shared Neighborhood Hits	172
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG1_MOUSE
NC score	0.768206 (rank : 13)	θ value	7.06379e-29 (rank : 15)
Query Neighborhood Hits	219	Target Neighborhood Hits	285	Shared Neighborhood Hits	166
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG1_HUMAN
NC score	0.766978 (rank : 14)	θ value	5.40856e-29 (rank : 14)
Query Neighborhood Hits	219	Target Neighborhood Hits	290	Shared Neighborhood Hits	168
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

SYJ2B_HUMAN
NC score	0.677362 (rank : 15)	θ value	0.0148317 (rank : 120)
Query Neighborhood Hits	219	Target Neighborhood Hits	162	Shared Neighborhood Hits	147
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

INADL_MOUSE
NC score	0.659855 (rank : 16)	θ value	1.33837e-11 (rank : 22)
Query Neighborhood Hits	219	Target Neighborhood Hits	290	Shared Neighborhood Hits	176
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

INADL_HUMAN
NC score	0.646526 (rank : 17)	θ value	6.64225e-11 (rank : 24)
Query Neighborhood Hits	219	Target Neighborhood Hits	260	Shared Neighborhood Hits	174
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

PDZ11_HUMAN
NC score	0.642921 (rank : 18)	θ value	2.61198e-07 (rank : 43)
Query Neighborhood Hits	219	Target Neighborhood Hits	160	Shared Neighborhood Hits	141
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
NC score	0.642343 (rank : 19)	θ value	3.41135e-07 (rank : 44)
Query Neighborhood Hits	219	Target Neighborhood Hits	154	Shared Neighborhood Hits	135
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

MPDZ_HUMAN
NC score	0.625869 (rank : 20)	θ value	4.0297e-08 (rank : 34)
Query Neighborhood Hits	219	Target Neighborhood Hits	261	Shared Neighborhood Hits	179
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
NC score	0.624529 (rank : 21)	θ value	6.87365e-08 (rank : 37)
Query Neighborhood Hits	219	Target Neighborhood Hits	298	Shared Neighborhood Hits	178
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

WHRN_HUMAN
NC score	0.612429 (rank : 22)	θ value	1.38499e-08 (rank : 32)
Query Neighborhood Hits	219	Target Neighborhood Hits	325	Shared Neighborhood Hits	174
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

USH1C_HUMAN
NC score	0.609755 (rank : 23)	θ value	5.26297e-08 (rank : 36)
Query Neighborhood Hits	219	Target Neighborhood Hits	327	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

WHRN_MOUSE
NC score	0.603813 (rank : 24)	θ value	6.87365e-08 (rank : 38)
Query Neighborhood Hits	219	Target Neighborhood Hits	412	Shared Neighborhood Hits	174
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PDZD7_HUMAN
NC score	0.600384 (rank : 25)	θ value	0.000121331 (rank : 75)
Query Neighborhood Hits	219	Target Neighborhood Hits	181	Shared Neighborhood Hits	159
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

LIN7B_HUMAN
NC score	0.598129 (rank : 26)	θ value	4.1701e-05 (rank : 63)
Query Neighborhood Hits	219	Target Neighborhood Hits	200	Shared Neighborhood Hits	174
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7C_HUMAN
NC score	0.596373 (rank : 27)	θ value	7.1131e-05 (rank : 70)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	172
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.596373 (rank : 28)	θ value	7.1131e-05 (rank : 71)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	172
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7B_MOUSE
NC score	0.595950 (rank : 29)	θ value	5.44631e-05 (rank : 66)
Query Neighborhood Hits	219	Target Neighborhood Hits	200	Shared Neighborhood Hits	174
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7A_HUMAN
NC score	0.588687 (rank : 30)	θ value	7.1131e-05 (rank : 68)
Query Neighborhood Hits	219	Target Neighborhood Hits	193	Shared Neighborhood Hits	171
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
NC score	0.588566 (rank : 31)	θ value	7.1131e-05 (rank : 69)
Query Neighborhood Hits	219	Target Neighborhood Hits	193	Shared Neighborhood Hits	171
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

GRIP2_HUMAN
NC score	0.588205 (rank : 32)	θ value	1.09739e-05 (rank : 53)
Query Neighborhood Hits	219	Target Neighborhood Hits	256	Shared Neighborhood Hits	172
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

MPP5_HUMAN
NC score	0.587901 (rank : 33)	θ value	9.90251e-15 (rank : 16)
Query Neighborhood Hits	219	Target Neighborhood Hits	231	Shared Neighborhood Hits	129
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.586971 (rank : 34)	θ value	2.20605e-14 (rank : 17)
Query Neighborhood Hits	219	Target Neighborhood Hits	226	Shared Neighborhood Hits	129
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

LNX2_MOUSE
NC score	0.586719 (rank : 35)	θ value	1.06045e-08 (rank : 29)
Query Neighborhood Hits	219	Target Neighborhood Hits	407	Shared Neighborhood Hits	167
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LNX1_MOUSE
NC score	0.583141 (rank : 36)	θ value	1.02475e-11 (rank : 21)
Query Neighborhood Hits	219	Target Neighborhood Hits	377	Shared Neighborhood Hits	160
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

GRIP1_HUMAN
NC score	0.582518 (rank : 37)	θ value	5.44631e-05 (rank : 64)
Query Neighborhood Hits	219	Target Neighborhood Hits	231	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
NC score	0.579722 (rank : 38)	θ value	4.92598e-06 (rank : 48)
Query Neighborhood Hits	219	Target Neighborhood Hits	241	Shared Neighborhood Hits	175
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

PDZD2_HUMAN
NC score	0.579490 (rank : 39)	θ value	7.59969e-07 (rank : 45)
Query Neighborhood Hits	219	Target Neighborhood Hits	772	Shared Neighborhood Hits	177
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

MAGI1_HUMAN
NC score	0.578738 (rank : 40)	θ value	2.69671e-12 (rank : 19)
Query Neighborhood Hits	219	Target Neighborhood Hits	388	Shared Neighborhood Hits	174
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

LNX1_HUMAN
NC score	0.577228 (rank : 41)	θ value	1.63604e-09 (rank : 25)
Query Neighborhood Hits	219	Target Neighborhood Hits	379	Shared Neighborhood Hits	155
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MAGI1_MOUSE
NC score	0.575354 (rank : 42)	θ value	2.0648e-12 (rank : 18)
Query Neighborhood Hits	219	Target Neighborhood Hits	403	Shared Neighborhood Hits	177
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

LNX2_HUMAN
NC score	0.570373 (rank : 43)	θ value	1.99992e-07 (rank : 41)
Query Neighborhood Hits	219	Target Neighborhood Hits	389	Shared Neighborhood Hits	167
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

MAGI2_MOUSE
NC score	0.562197 (rank : 44)	θ value	2.69671e-12 (rank : 20)
Query Neighborhood Hits	219	Target Neighborhood Hits	370	Shared Neighborhood Hits	174
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

DLG5_HUMAN
NC score	0.562045 (rank : 45)	θ value	3.3877e-31 (rank : 9)
Query Neighborhood Hits	219	Target Neighborhood Hits	1088	Shared Neighborhood Hits	169
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

IL16_HUMAN
NC score	0.561173 (rank : 46)	θ value	5.44631e-05 (rank : 65)
Query Neighborhood Hits	219	Target Neighborhood Hits	207	Shared Neighborhood Hits	136
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

GOPC_MOUSE
NC score	0.558340 (rank : 47)	θ value	3.19293e-05 (rank : 59)
Query Neighborhood Hits	219	Target Neighborhood Hits	323	Shared Neighborhood Hits	156
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

USH1C_MOUSE
NC score	0.557484 (rank : 48)	θ value	0.00020696 (rank : 79)
Query Neighborhood Hits	219	Target Neighborhood Hits	557	Shared Neighborhood Hits	177
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

MAGI2_HUMAN
NC score	0.555400 (rank : 49)	θ value	2.28291e-11 (rank : 23)
Query Neighborhood Hits	219	Target Neighborhood Hits	373	Shared Neighborhood Hits	170
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

TX1B3_HUMAN
NC score	0.554659 (rank : 50)	θ value	0.0252991 (rank : 126)
Query Neighborhood Hits	219	Target Neighborhood Hits	161	Shared Neighborhood Hits	146
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.552759 (rank : 51)	θ value	0.0252991 (rank : 127)
Query Neighborhood Hits	219	Target Neighborhood Hits	158	Shared Neighborhood Hits	143
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

GOPC_HUMAN
NC score	0.548636 (rank : 52)	θ value	3.19293e-05 (rank : 58)
Query Neighborhood Hits	219	Target Neighborhood Hits	377	Shared Neighborhood Hits	156
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

PAR3L_HUMAN
NC score	0.546935 (rank : 53)	θ value	0.0330416 (rank : 128)
Query Neighborhood Hits	219	Target Neighborhood Hits	297	Shared Neighborhood Hits	143
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

SNTG2_HUMAN
NC score	0.544249 (rank : 54)	θ value	4.92598e-06 (rank : 49)
Query Neighborhood Hits	219	Target Neighborhood Hits	191	Shared Neighborhood Hits	162
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

IL16_MOUSE
NC score	0.539849 (rank : 55)	θ value	7.1131e-05 (rank : 67)
Query Neighborhood Hits	219	Target Neighborhood Hits	189	Shared Neighborhood Hits	133
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PARD3_HUMAN
NC score	0.539225 (rank : 56)	θ value	0.00869519 (rank : 112)
Query Neighborhood Hits	219	Target Neighborhood Hits	312	Shared Neighborhood Hits	152
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
NC score	0.536290 (rank : 57)	θ value	0.00869519 (rank : 113)
Query Neighborhood Hits	219	Target Neighborhood Hits	290	Shared Neighborhood Hits	149
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

SNTB2_MOUSE
NC score	0.521396 (rank : 58)	θ value	6.43352e-06 (rank : 52)
Query Neighborhood Hits	219	Target Neighborhood Hits	181	Shared Neighborhood Hits	149
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_HUMAN
NC score	0.520303 (rank : 59)	θ value	1.43324e-05 (rank : 55)
Query Neighborhood Hits	219	Target Neighborhood Hits	180	Shared Neighborhood Hits	150
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

PDZD1_MOUSE
NC score	0.519054 (rank : 60)	θ value	0.0563607 (rank : 131)
Query Neighborhood Hits	219	Target Neighborhood Hits	191	Shared Neighborhood Hits	152
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

SNTG2_MOUSE
NC score	0.516053 (rank : 61)	θ value	1.09739e-05 (rank : 54)
Query Neighborhood Hits	219	Target Neighborhood Hits	176	Shared Neighborhood Hits	150
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

PDZD1_HUMAN
NC score	0.513306 (rank : 62)	θ value	0.00298849 (rank : 100)
Query Neighborhood Hits	219	Target Neighborhood Hits	190	Shared Neighborhood Hits	149
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PZRN4_HUMAN
NC score	0.509606 (rank : 63)	θ value	3.77169e-06 (rank : 47)
Query Neighborhood Hits	219	Target Neighborhood Hits	438	Shared Neighborhood Hits	146
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

PZRN3_HUMAN
NC score	0.507214 (rank : 64)	θ value	4.76016e-09 (rank : 27)
Query Neighborhood Hits	219	Target Neighborhood Hits	461	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
NC score	0.505388 (rank : 65)	θ value	8.97725e-08 (rank : 39)
Query Neighborhood Hits	219	Target Neighborhood Hits	447	Shared Neighborhood Hits	147
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SNTA1_HUMAN
NC score	0.505355 (rank : 66)	θ value	0.00134147 (rank : 91)
Query Neighborhood Hits	219	Target Neighborhood Hits	186	Shared Neighborhood Hits	153
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

MPP3_HUMAN
NC score	0.500766 (rank : 67)	θ value	6.43352e-06 (rank : 51)
Query Neighborhood Hits	219	Target Neighborhood Hits	171	Shared Neighborhood Hits	121
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

SNTA1_MOUSE
NC score	0.499589 (rank : 68)	θ value	0.00175202 (rank : 94)
Query Neighborhood Hits	219	Target Neighborhood Hits	170	Shared Neighborhood Hits	149
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTG1_HUMAN
NC score	0.494459 (rank : 69)	θ value	0.000602161 (rank : 86)
Query Neighborhood Hits	219	Target Neighborhood Hits	181	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
NC score	0.494308 (rank : 70)	θ value	0.000602161 (rank : 87)
Query Neighborhood Hits	219	Target Neighborhood Hits	179	Shared Neighborhood Hits	153
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

MPP3_MOUSE
NC score	0.493949 (rank : 71)	θ value	0.000786445 (rank : 89)
Query Neighborhood Hits	219	Target Neighborhood Hits	165	Shared Neighborhood Hits	120
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

SNTB1_HUMAN
NC score	0.490684 (rank : 72)	θ value	0.00228821 (rank : 97)
Query Neighborhood Hits	219	Target Neighborhood Hits	157	Shared Neighborhood Hits	140
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.488978 (rank : 73)	θ value	0.00228821 (rank : 98)
Query Neighborhood Hits	219	Target Neighborhood Hits	160	Shared Neighborhood Hits	138
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

MPP2_MOUSE
NC score	0.484220 (rank : 74)	θ value	4.76016e-09 (rank : 26)
Query Neighborhood Hits	219	Target Neighborhood Hits	189	Shared Neighborhood Hits	94
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

EM55_MOUSE
NC score	0.483397 (rank : 75)	θ value	0.0113563 (rank : 116)
Query Neighborhood Hits	219	Target Neighborhood Hits	221	Shared Neighborhood Hits	110
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MPP2_HUMAN
NC score	0.480182 (rank : 76)	θ value	1.38499e-08 (rank : 31)
Query Neighborhood Hits	219	Target Neighborhood Hits	173	Shared Neighborhood Hits	89
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

EM55_HUMAN
NC score	0.477105 (rank : 77)	θ value	0.00228821 (rank : 96)
Query Neighborhood Hits	219	Target Neighborhood Hits	228	Shared Neighborhood Hits	112
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

MPP6_HUMAN
NC score	0.474591 (rank : 78)	θ value	2.61198e-07 (rank : 42)
Query Neighborhood Hits	219	Target Neighborhood Hits	180	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
NC score	0.469015 (rank : 79)	θ value	1.29631e-06 (rank : 46)
Query Neighborhood Hits	219	Target Neighborhood Hits	187	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NHERF_MOUSE
NC score	0.468559 (rank : 80)	θ value	0.279714 (rank : 147)
Query Neighborhood Hits	219	Target Neighborhood Hits	195	Shared Neighborhood Hits	152
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD3_HUMAN
NC score	0.464778 (rank : 81)	θ value	0.0330416 (rank : 130)
Query Neighborhood Hits	219	Target Neighborhood Hits	180	Shared Neighborhood Hits	153
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

MPP4_HUMAN
NC score	0.462155 (rank : 82)	θ value	0.365318 (rank : 153)
Query Neighborhood Hits	219	Target Neighborhood Hits	205	Shared Neighborhood Hits	130
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

NHRF2_HUMAN
NC score	0.460592 (rank : 83)	θ value	0.00665767 (rank : 107)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	161
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
NC score	0.448395 (rank : 84)	θ value	0.00665767 (rank : 108)
Query Neighborhood Hits	219	Target Neighborhood Hits	194	Shared Neighborhood Hits	162
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NHERF_HUMAN
NC score	0.448125 (rank : 85)	θ value	0.47712 (rank : 159)
Query Neighborhood Hits	219	Target Neighborhood Hits	190	Shared Neighborhood Hits	152
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

MPP4_MOUSE
NC score	0.439094 (rank : 86)	θ value	0.813845 (rank : 167)
Query Neighborhood Hits	219	Target Neighborhood Hits	188	Shared Neighborhood Hits	113
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PDZD3_MOUSE
NC score	0.418722 (rank : 87)	θ value	0.163984 (rank : 146)
Query Neighborhood Hits	219	Target Neighborhood Hits	171	Shared Neighborhood Hits	150
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

LAP4_HUMAN
NC score	0.417228 (rank : 88)	θ value	3.19293e-05 (rank : 60)
Query Neighborhood Hits	219	Target Neighborhood Hits	608	Shared Neighborhood Hits	180
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

PDZK4_MOUSE
NC score	0.415188 (rank : 89)	θ value	0.00175202 (rank : 93)
Query Neighborhood Hits	219	Target Neighborhood Hits	165	Shared Neighborhood Hits	123
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_HUMAN
NC score	0.414862 (rank : 90)	θ value	0.00035302 (rank : 84)
Query Neighborhood Hits	219	Target Neighborhood Hits	165	Shared Neighborhood Hits	115
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

LAP4_MOUSE
NC score	0.412736 (rank : 91)	θ value	1.87187e-05 (rank : 56)
Query Neighborhood Hits	219	Target Neighborhood Hits	590	Shared Neighborhood Hits	178
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

DVL3_HUMAN
NC score	0.410278 (rank : 92)	θ value	0.000270298 (rank : 80)
Query Neighborhood Hits	219	Target Neighborhood Hits	194	Shared Neighborhood Hits	112
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
NC score	0.410069 (rank : 93)	θ value	0.000270298 (rank : 81)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	112
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1_HUMAN
NC score	0.408218 (rank : 94)	θ value	0.000121331 (rank : 73)
Query Neighborhood Hits	219	Target Neighborhood Hits	158	Shared Neighborhood Hits	115
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
NC score	0.404380 (rank : 95)	θ value	0.000121331 (rank : 74)
Query Neighborhood Hits	219	Target Neighborhood Hits	146	Shared Neighborhood Hits	114
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

K1849_MOUSE
NC score	0.401957 (rank : 96)	θ value	0.0252991 (rank : 123)
Query Neighborhood Hits	219	Target Neighborhood Hits	335	Shared Neighborhood Hits	140
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_HUMAN
NC score	0.401102 (rank : 97)	θ value	0.365318 (rank : 151)
Query Neighborhood Hits	219	Target Neighborhood Hits	220	Shared Neighborhood Hits	131
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

DVL1L_HUMAN
NC score	0.397571 (rank : 98)	θ value	0.000158464 (rank : 76)
Query Neighborhood Hits	219	Target Neighborhood Hits	146	Shared Neighborhood Hits	111
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_HUMAN
NC score	0.391762 (rank : 99)	θ value	0.00035302 (rank : 83)
Query Neighborhood Hits	219	Target Neighborhood Hits	223	Shared Neighborhood Hits	113
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
NC score	0.391173 (rank : 100)	θ value	0.000602161 (rank : 85)
Query Neighborhood Hits	219	Target Neighborhood Hits	233	Shared Neighborhood Hits	112
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

SDCB1_MOUSE
NC score	0.381427 (rank : 101)	θ value	0.00665767 (rank : 110)
Query Neighborhood Hits	219	Target Neighborhood Hits	144	Shared Neighborhood Hits	128
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SDCB1_HUMAN
NC score	0.378853 (rank : 102)	θ value	0.00665767 (rank : 109)
Query Neighborhood Hits	219	Target Neighborhood Hits	150	Shared Neighborhood Hits	129
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

PTN13_HUMAN
NC score	0.378613 (rank : 103)	θ value	4.0297e-08 (rank : 35)
Query Neighborhood Hits	219	Target Neighborhood Hits	471	Shared Neighborhood Hits	170
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

AFAD_HUMAN
NC score	0.375565 (rank : 104)	θ value	0.00665767 (rank : 105)
Query Neighborhood Hits	219	Target Neighborhood Hits	689	Shared Neighborhood Hits	140
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

PTN13_MOUSE
NC score	0.371842 (rank : 105)	θ value	1.53129e-07 (rank : 40)
Query Neighborhood Hits	219	Target Neighborhood Hits	426	Shared Neighborhood Hits	174
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

RPGF6_HUMAN
NC score	0.361822 (rank : 106)	θ value	1.87187e-05 (rank : 57)
Query Neighborhood Hits	219	Target Neighborhood Hits	266	Shared Neighborhood Hits	145
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

KGUA_MOUSE
NC score	0.359757 (rank : 107)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	219	Target Neighborhood Hits	45	Shared Neighborhood Hits	30
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_HUMAN
NC score	0.354016 (rank : 108)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	219	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

NEB1_HUMAN
NC score	0.351528 (rank : 109)	θ value	0.00869519 (rank : 111)
Query Neighborhood Hits	219	Target Neighborhood Hits	829	Shared Neighborhood Hits	123
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

APBA1_HUMAN
NC score	0.345289 (rank : 110)	θ value	0.47712 (rank : 156)
Query Neighborhood Hits	219	Target Neighborhood Hits	325	Shared Neighborhood Hits	138
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

NEB2_HUMAN
NC score	0.336961 (rank : 111)	θ value	0.0252991 (rank : 124)
Query Neighborhood Hits	219	Target Neighborhood Hits	883	Shared Neighborhood Hits	113
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PDLI2_HUMAN
NC score	0.334071 (rank : 112)	θ value	0.125558 (rank : 142)
Query Neighborhood Hits	219	Target Neighborhood Hits	245	Shared Neighborhood Hits	124
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

NEB2_MOUSE
NC score	0.332841 (rank : 113)	θ value	0.0252991 (rank : 125)
Query Neighborhood Hits	219	Target Neighborhood Hits	889	Shared Neighborhood Hits	114
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

APBA3_MOUSE
NC score	0.326833 (rank : 114)	θ value	0.0193708 (rank : 121)
Query Neighborhood Hits	219	Target Neighborhood Hits	174	Shared Neighborhood Hits	119
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

STXB4_HUMAN
NC score	0.323913 (rank : 115)	θ value	0.00298849 (rank : 101)
Query Neighborhood Hits	219	Target Neighborhood Hits	616	Shared Neighborhood Hits	104
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SDCB2_MOUSE
NC score	0.320885 (rank : 116)	θ value	0.0961366 (rank : 139)
Query Neighborhood Hits	219	Target Neighborhood Hits	118	Shared Neighborhood Hits	102
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

APBA2_HUMAN
NC score	0.317309 (rank : 117)	θ value	0.62314 (rank : 162)
Query Neighborhood Hits	219	Target Neighborhood Hits	220	Shared Neighborhood Hits	135
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
NC score	0.317016 (rank : 118)	θ value	0.62314 (rank : 163)
Query Neighborhood Hits	219	Target Neighborhood Hits	219	Shared Neighborhood Hits	135
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

RPGF2_HUMAN
NC score	0.317013 (rank : 119)	θ value	0.000270298 (rank : 82)
Query Neighborhood Hits	219	Target Neighborhood Hits	242	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

STXB4_MOUSE
NC score	0.314406 (rank : 120)	θ value	0.000602161 (rank : 88)
Query Neighborhood Hits	219	Target Neighborhood Hits	629	Shared Neighborhood Hits	97
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PICK1_MOUSE
NC score	0.308405 (rank : 121)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	219	Target Neighborhood Hits	131	Shared Neighborhood Hits	110
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

APBA3_HUMAN
NC score	0.306623 (rank : 122)	θ value	1.38821 (rank : 172)
Query Neighborhood Hits	219	Target Neighborhood Hits	201	Shared Neighborhood Hits	127
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PICK1_HUMAN
NC score	0.306091 (rank : 123)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	219	Target Neighborhood Hits	132	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SDCB2_HUMAN
NC score	0.305758 (rank : 124)	θ value	0.279714 (rank : 149)
Query Neighborhood Hits	219	Target Neighborhood Hits	121	Shared Neighborhood Hits	112
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PDLI2_MOUSE
NC score	0.305213 (rank : 125)	θ value	0.279714 (rank : 148)
Query Neighborhood Hits	219	Target Neighborhood Hits	220	Shared Neighborhood Hits	118
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

SYP2L_HUMAN
NC score	0.289647 (rank : 126)	θ value	0.279714 (rank : 150)
Query Neighborhood Hits	219	Target Neighborhood Hits	400	Shared Neighborhood Hits	112
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

ARHGB_HUMAN
NC score	0.275722 (rank : 127)	θ value	0.00102713 (rank : 90)
Query Neighborhood Hits	219	Target Neighborhood Hits	375	Shared Neighborhood Hits	153
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

PAR6B_MOUSE
NC score	0.274121 (rank : 128)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	219	Target Neighborhood Hits	128	Shared Neighborhood Hits	111
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

RHPN1_MOUSE
NC score	0.273470 (rank : 129)	θ value	0.365318 (rank : 154)
Query Neighborhood Hits	219	Target Neighborhood Hits	154	Shared Neighborhood Hits	128
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PAR6B_HUMAN
NC score	0.271460 (rank : 130)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	219	Target Neighborhood Hits	126	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
NC score	0.267734 (rank : 131)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	219	Target Neighborhood Hits	159	Shared Neighborhood Hits	108
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
NC score	0.266976 (rank : 132)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	219	Target Neighborhood Hits	121	Shared Neighborhood Hits	105
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

CAR14_HUMAN
NC score	0.266929 (rank : 133)	θ value	1.38499e-08 (rank : 30)
Query Neighborhood Hits	219	Target Neighborhood Hits	449	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

SYNP2_MOUSE
NC score	0.256542 (rank : 134)	θ value	0.00298849 (rank : 102)
Query Neighborhood Hits	219	Target Neighborhood Hits	252	Shared Neighborhood Hits	120
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

PAR6A_MOUSE
NC score	0.256400 (rank : 135)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	219	Target Neighborhood Hits	115	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6A_HUMAN
NC score	0.256180 (rank : 136)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	219	Target Neighborhood Hits	119	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

ARHGC_HUMAN
NC score	0.254494 (rank : 137)	θ value	0.0961366 (rank : 133)
Query Neighborhood Hits	219	Target Neighborhood Hits	351	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

NOS1_HUMAN
NC score	0.253194 (rank : 138)	θ value	0.0961366 (rank : 136)
Query Neighborhood Hits	219	Target Neighborhood Hits	218	Shared Neighborhood Hits	131
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

ARHGC_MOUSE
NC score	0.249873 (rank : 139)	θ value	0.125558 (rank : 140)
Query Neighborhood Hits	219	Target Neighborhood Hits	344	Shared Neighborhood Hits	140
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GRASP_HUMAN
NC score	0.248961 (rank : 140)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	219	Target Neighborhood Hits	147	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

LRRC7_HUMAN
NC score	0.248889 (rank : 141)	θ value	0.000158464 (rank : 77)
Query Neighborhood Hits	219	Target Neighborhood Hits	423	Shared Neighborhood Hits	112
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.248128 (rank : 142)	θ value	0.000158464 (rank : 78)
Query Neighborhood Hits	219	Target Neighborhood Hits	416	Shared Neighborhood Hits	112
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

RHPN1_HUMAN
NC score	0.247918 (rank : 143)	θ value	6.88961 (rank : 208)
Query Neighborhood Hits	219	Target Neighborhood Hits	158	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

GRASP_MOUSE
NC score	0.245002 (rank : 144)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	219	Target Neighborhood Hits	131	Shared Neighborhood Hits	114
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

LAP2_HUMAN
NC score	0.239944 (rank : 145)	θ value	4.1701e-05 (rank : 61)
Query Neighborhood Hits	219	Target Neighborhood Hits	499	Shared Neighborhood Hits	106
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

RGS12_HUMAN
NC score	0.239807 (rank : 146)	θ value	0.00509761 (rank : 104)
Query Neighborhood Hits	219	Target Neighborhood Hits	333	Shared Neighborhood Hits	132
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

CAR11_HUMAN
NC score	0.238960 (rank : 147)	θ value	4.0297e-08 (rank : 33)
Query Neighborhood Hits	219	Target Neighborhood Hits	690	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

PSCBP_MOUSE
NC score	0.236176 (rank : 148)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	219	Target Neighborhood Hits	118	Shared Neighborhood Hits	107
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

CAR14_MOUSE
NC score	0.235007 (rank : 149)	θ value	6.21693e-09 (rank : 28)
Query Neighborhood Hits	219	Target Neighborhood Hits	526	Shared Neighborhood Hits	34
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

LAP2_MOUSE
NC score	0.231583 (rank : 150)	θ value	4.1701e-05 (rank : 62)
Query Neighborhood Hits	219	Target Neighborhood Hits	482	Shared Neighborhood Hits	104
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PSCBP_HUMAN
NC score	0.230271 (rank : 151)	θ value	0.47712 (rank : 160)
Query Neighborhood Hits	219	Target Neighborhood Hits	123	Shared Neighborhood Hits	109
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

SYP2L_MOUSE
NC score	0.219365 (rank : 152)	θ value	0.813845 (rank : 169)
Query Neighborhood Hits	219	Target Neighborhood Hits	289	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PDLI4_MOUSE
NC score	0.219209 (rank : 153)	θ value	0.0961366 (rank : 138)
Query Neighborhood Hits	219	Target Neighborhood Hits	233	Shared Neighborhood Hits	107
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

CAR10_MOUSE
NC score	0.216476 (rank : 154)	θ value	6.43352e-06 (rank : 50)
Query Neighborhood Hits	219	Target Neighborhood Hits	407	Shared Neighborhood Hits	23
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

PDLI3_HUMAN
NC score	0.216448 (rank : 155)	θ value	2.36792 (rank : 185)
Query Neighborhood Hits	219	Target Neighborhood Hits	199	Shared Neighborhood Hits	105
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

SYNP2_HUMAN
NC score	0.209271 (rank : 156)	θ value	0.0736092 (rank : 132)
Query Neighborhood Hits	219	Target Neighborhood Hits	323	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

NOS1_MOUSE
NC score	0.206689 (rank : 157)	θ value	0.163984 (rank : 145)
Query Neighborhood Hits	219	Target Neighborhood Hits	155	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDLI3_MOUSE
NC score	0.199488 (rank : 158)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	101
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

APXL_HUMAN
NC score	0.194301 (rank : 159)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	219	Target Neighborhood Hits	553	Shared Neighborhood Hits	94
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

PDLI4_HUMAN
NC score	0.194070 (rank : 160)	θ value	2.36792 (rank : 186)
Query Neighborhood Hits	219	Target Neighborhood Hits	245	Shared Neighborhood Hits	107
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

SHAN2_HUMAN
NC score	0.192183 (rank : 161)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	219	Target Neighborhood Hits	346	Shared Neighborhood Hits	117
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

RIMS1_HUMAN
NC score	0.189859 (rank : 162)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	219	Target Neighborhood Hits	437	Shared Neighborhood Hits	115
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

PDLI1_HUMAN
NC score	0.185685 (rank : 163)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	219	Target Neighborhood Hits	242	Shared Neighborhood Hits	95
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

RIMS2_MOUSE
NC score	0.183413 (rank : 164)	θ value	0.00869519 (rank : 115)
Query Neighborhood Hits	219	Target Neighborhood Hits	376	Shared Neighborhood Hits	96
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
NC score	0.183331 (rank : 165)	θ value	0.00869519 (rank : 114)
Query Neighborhood Hits	219	Target Neighborhood Hits	342	Shared Neighborhood Hits	95
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

PDLI1_MOUSE
NC score	0.177881 (rank : 166)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	219	Target Neighborhood Hits	213	Shared Neighborhood Hits	95
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PRAX_MOUSE
NC score	0.176794 (rank : 167)	θ value	0.0193708 (rank : 122)
Query Neighborhood Hits	219	Target Neighborhood Hits	199	Shared Neighborhood Hits	44
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

CAR10_HUMAN
NC score	0.174573 (rank : 168)	θ value	0.00509761 (rank : 103)
Query Neighborhood Hits	219	Target Neighborhood Hits	569	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

PDLI5_HUMAN
NC score	0.172131 (rank : 169)	θ value	0.0330416 (rank : 129)
Query Neighborhood Hits	219	Target Neighborhood Hits	322	Shared Neighborhood Hits	112
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

SHAN2_MOUSE
NC score	0.168922 (rank : 170)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	219	Target Neighborhood Hits	446	Shared Neighborhood Hits	117
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

PDLI5_MOUSE
NC score	0.164978 (rank : 171)	θ value	0.125558 (rank : 143)
Query Neighborhood Hits	219	Target Neighborhood Hits	287	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

LDB3_MOUSE
NC score	0.164182 (rank : 172)	θ value	0.0961366 (rank : 135)
Query Neighborhood Hits	219	Target Neighborhood Hits	510	Shared Neighborhood Hits	100
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LDB3_HUMAN
NC score	0.162744 (rank : 173)	θ value	0.0961366 (rank : 134)
Query Neighborhood Hits	219	Target Neighborhood Hits	497	Shared Neighborhood Hits	104
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

CSKP_HUMAN
NC score	0.162105 (rank : 174)	θ value	0.000121331 (rank : 72)
Query Neighborhood Hits	219	Target Neighborhood Hits	1022	Shared Neighborhood Hits	110
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

PCLO_MOUSE
NC score	0.160731 (rank : 175)	θ value	0.0961366 (rank : 137)
Query Neighborhood Hits	219	Target Neighborhood Hits	2275	Shared Neighborhood Hits	133
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

GIPC1_MOUSE
NC score	0.154100 (rank : 176)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	219	Target Neighborhood Hits	92	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

PRAX_HUMAN
NC score	0.151361 (rank : 177)	θ value	0.0148317 (rank : 118)
Query Neighborhood Hits	219	Target Neighborhood Hits	215	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

CSKP_MOUSE
NC score	0.150960 (rank : 178)	θ value	0.0148317 (rank : 117)
Query Neighborhood Hits	219	Target Neighborhood Hits	1027	Shared Neighborhood Hits	111
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

LMO7_HUMAN
NC score	0.148714 (rank : 179)	θ value	0.00665767 (rank : 106)
Query Neighborhood Hits	219	Target Neighborhood Hits	507	Shared Neighborhood Hits	58
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

GIPC1_HUMAN
NC score	0.147462 (rank : 180)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	219	Target Neighborhood Hits	91	Shared Neighborhood Hits	77
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

PDLI7_HUMAN
NC score	0.146555 (rank : 181)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	219	Target Neighborhood Hits	547	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PTN4_HUMAN
NC score	0.139539 (rank : 182)	θ value	0.0148317 (rank : 119)
Query Neighborhood Hits	219	Target Neighborhood Hits	303	Shared Neighborhood Hits	111
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PDLI7_MOUSE
NC score	0.128254 (rank : 183)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	219	Target Neighborhood Hits	279	Shared Neighborhood Hits	97
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PTN3_HUMAN
NC score	0.124743 (rank : 184)	θ value	0.47712 (rank : 161)
Query Neighborhood Hits	219	Target Neighborhood Hits	258	Shared Neighborhood Hits	110
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PDZD6_HUMAN
NC score	0.124326 (rank : 185)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	219	Target Neighborhood Hits	81	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

SHAN1_HUMAN
NC score	0.123800 (rank : 186)	θ value	1.06291 (rank : 171)
Query Neighborhood Hits	219	Target Neighborhood Hits	1041	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

GIPC2_HUMAN
NC score	0.110851 (rank : 187)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	219	Target Neighborhood Hits	93	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

PDZD8_HUMAN
NC score	0.108724 (rank : 188)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	219	Target Neighborhood Hits	185	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

HTRA3_MOUSE
NC score	0.105217 (rank : 189)	θ value	1.81305 (rank : 177)
Query Neighborhood Hits	219	Target Neighborhood Hits	156	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

TIAM1_HUMAN
NC score	0.099532 (rank : 190)	θ value	0.00175202 (rank : 95)
Query Neighborhood Hits	219	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

HTRA3_HUMAN
NC score	0.094899 (rank : 191)	θ value	1.81305 (rank : 176)
Query Neighborhood Hits	219	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

GRB2_MOUSE
NC score	0.086494 (rank : 192)	θ value	0.00175202 (rank : 92)
Query Neighborhood Hits	219	Target Neighborhood Hits	312	Shared Neighborhood Hits	28
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.085623 (rank : 193)	θ value	0.00298849 (rank : 99)
Query Neighborhood Hits	219	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

CRK_HUMAN
NC score	0.082932 (rank : 194)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	219	Target Neighborhood Hits	308	Shared Neighborhood Hits	27
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CACB1_MOUSE
NC score	0.082221 (rank : 195)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	219	Target Neighborhood Hits	46	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CRK_MOUSE
NC score	0.081710 (rank : 196)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	219	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CNKR2_MOUSE
NC score	0.078445 (rank : 197)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	46
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CACB1_HUMAN
NC score	0.078416 (rank : 198)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	219	Target Neighborhood Hits	44	Shared Neighborhood Hits	21
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CNKR2_HUMAN
NC score	0.078375 (rank : 199)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CACB4_HUMAN
NC score	0.076203 (rank : 200)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	219	Target Neighborhood Hits	47	Shared Neighborhood Hits	18
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

TIAM1_MOUSE
NC score	0.075497 (rank : 201)	θ value	0.365318 (rank : 155)
Query Neighborhood Hits	219	Target Neighborhood Hits	205	Shared Neighborhood Hits	43
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CACB4_MOUSE
NC score	0.073931 (rank : 202)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	219	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CACB3_HUMAN
NC score	0.073784 (rank : 203)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	219	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CACB3_MOUSE
NC score	0.073340 (rank : 204)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	219	Target Neighborhood Hits	48	Shared Neighborhood Hits	17
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

STAM1_MOUSE
NC score	0.072347 (rank : 205)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	219	Target Neighborhood Hits	273	Shared Neighborhood Hits	27
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GIPC2_MOUSE
NC score	0.063942 (rank : 206)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	219	Target Neighborhood Hits	71	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

STAM2_MOUSE
NC score	0.063840 (rank : 207)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	219	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM1_HUMAN
NC score	0.063529 (rank : 208)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	219	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

RNF41_MOUSE
NC score	0.062207 (rank : 209)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	219	Target Neighborhood Hits	224	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_HUMAN
NC score	0.062101 (rank : 210)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	219	Target Neighborhood Hits	226	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

GIPC3_MOUSE
NC score	0.062095 (rank : 211)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	219	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

GIPC3_HUMAN
NC score	0.061772 (rank : 212)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	219	Target Neighborhood Hits	52	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

HTRA1_HUMAN
NC score	0.061732 (rank : 213)	θ value	1.81305 (rank : 175)
Query Neighborhood Hits	219	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
NC score	0.060582 (rank : 214)	θ value	2.36792 (rank : 183)
Query Neighborhood Hits	219	Target Neighborhood Hits	140	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

NPHP1_MOUSE
NC score	0.059643 (rank : 215)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	219	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CARD9_HUMAN
NC score	0.058037 (rank : 216)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	219	Target Neighborhood Hits	602	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CRKL_MOUSE
NC score	0.057645 (rank : 217)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

RGS3_HUMAN
NC score	0.057173 (rank : 218)	θ value	1.38821 (rank : 173)
Query Neighborhood Hits	219	Target Neighborhood Hits	1375	Shared Neighborhood Hits	75
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CACB2_HUMAN
NC score	0.056966 (rank : 219)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	219	Target Neighborhood Hits	99	Shared Neighborhood Hits	19
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

STAM2_HUMAN
NC score	0.056096 (rank : 220)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	219	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CRKL_HUMAN
NC score	0.055729 (rank : 221)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	219	Target Neighborhood Hits	313	Shared Neighborhood Hits	26
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SAV1_MOUSE
NC score	0.053881 (rank : 222)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	219	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SAV1_HUMAN
NC score	0.053847 (rank : 223)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	219	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

RGS3_MOUSE
NC score	0.052868 (rank : 224)	θ value	2.36792 (rank : 187)
Query Neighborhood Hits	219	Target Neighborhood Hits	1621	Shared Neighborhood Hits	86
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CACB2_MOUSE
NC score	0.051325 (rank : 225)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	219	Target Neighborhood Hits	94	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CC27, Q8C5J5, Q9CTQ6	Gene names	Cacnb2, Cacnlb2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).

MAST4_HUMAN
NC score	0.047382 (rank : 226)	θ value	0.62314 (rank : 164)
Query Neighborhood Hits	219	Target Neighborhood Hits	1804	Shared Neighborhood Hits	129
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MAST2_HUMAN
NC score	0.045270 (rank : 227)	θ value	0.47712 (rank : 157)
Query Neighborhood Hits	219	Target Neighborhood Hits	1189	Shared Neighborhood Hits	116
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
NC score	0.043570 (rank : 228)	θ value	0.47712 (rank : 158)
Query Neighborhood Hits	219	Target Neighborhood Hits	1110	Shared Neighborhood Hits	116
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
NC score	0.040237 (rank : 229)	θ value	0.365318 (rank : 152)
Query Neighborhood Hits	219	Target Neighborhood Hits	1128	Shared Neighborhood Hits	115
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST1_MOUSE
NC score	0.039539 (rank : 230)	θ value	2.36792 (rank : 184)
Query Neighborhood Hits	219	Target Neighborhood Hits	1123	Shared Neighborhood Hits	114
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_HUMAN
NC score	0.038094 (rank : 231)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	219	Target Neighborhood Hits	1146	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

OSTF1_HUMAN
NC score	0.036478 (rank : 232)	θ value	6.88961 (rank : 207)
Query Neighborhood Hits	219	Target Neighborhood Hits	466	Shared Neighborhood Hits	27
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SRRM2_HUMAN
NC score	0.029303 (rank : 233)	θ value	6.88961 (rank : 209)
Query Neighborhood Hits	219	Target Neighborhood Hits	1296	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

LIMK2_MOUSE
NC score	0.027851 (rank : 234)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	219	Target Neighborhood Hits	998	Shared Neighborhood Hits	67
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

IRS2_MOUSE
NC score	0.026466 (rank : 235)	θ value	0.125558 (rank : 141)
Query Neighborhood Hits	219	Target Neighborhood Hits	248	Shared Neighborhood Hits	15
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

LIMK2_HUMAN
NC score	0.025753 (rank : 236)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	219	Target Neighborhood Hits	986	Shared Neighborhood Hits	69
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

IWS1_HUMAN
NC score	0.023860 (rank : 237)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	219	Target Neighborhood Hits	1241	Shared Neighborhood Hits	29
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

GGN_MOUSE
NC score	0.022214 (rank : 238)	θ value	2.36792 (rank : 180)
Query Neighborhood Hits	219	Target Neighborhood Hits	311	Shared Neighborhood Hits	12
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GYS1_MOUSE
NC score	0.018920 (rank : 239)	θ value	2.36792 (rank : 181)
Query Neighborhood Hits	219	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1E4	Gene names	Gys1, Gys
Domain Architecture
Description	Glycogen [starch] synthase, muscle (EC 2.4.1.11).

GYS3_MOUSE
NC score	0.018872 (rank : 240)	θ value	2.36792 (rank : 182)
Query Neighborhood Hits	219	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	P54859	Gene names	Gys3
Domain Architecture
Description	Glycogen [starch] synthase, brain (EC 2.4.1.11).

DSPP_HUMAN
NC score	0.018490 (rank : 241)	θ value	8.99809 (rank : 213)
Query Neighborhood Hits	219	Target Neighborhood Hits	645	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

LIMA1_MOUSE
NC score	0.018341 (rank : 242)	θ value	3.0926 (rank : 189)
Query Neighborhood Hits	219	Target Neighborhood Hits	298	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ERG0, Q9ERG1	Gene names	Lima1, D15Ertd366e, Eplin
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN).

FILA_HUMAN
NC score	0.018190 (rank : 243)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	219	Target Neighborhood Hits	685	Shared Neighborhood Hits	23
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

GYS1_HUMAN
NC score	0.015929 (rank : 244)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	219	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	P13807	Gene names	GYS1, GYS
Domain Architecture
Description	Glycogen [starch] synthase, muscle (EC 2.4.1.11).

ABTAP_HUMAN
NC score	0.014778 (rank : 245)	θ value	0.813845 (rank : 166)
Query Neighborhood Hits	219	Target Neighborhood Hits	290	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

LIMA1_HUMAN
NC score	0.013689 (rank : 246)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	219	Target Neighborhood Hits	309	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UHB6, Q2TAN7, Q9BVF2, Q9H8J1, Q9HBN5, Q9NX96, Q9NXC3, Q9NXU6, Q9P0H8, Q9UHB5	Gene names	LIMA1, EPLIN, SREBP3
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm).

NGAP_HUMAN
NC score	0.012476 (rank : 247)	θ value	1.06291 (rank : 170)
Query Neighborhood Hits	219	Target Neighborhood Hits	517	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

SAPS1_HUMAN
NC score	0.011714 (rank : 248)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	219	Target Neighborhood Hits	704	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

KI20A_MOUSE
NC score	0.011526 (rank : 249)	θ value	0.163984 (rank : 144)
Query Neighborhood Hits	219	Target Neighborhood Hits	310	Shared Neighborhood Hits	6
SwissProt Accessions	P97329, Q542M4	Gene names	Kif20a, Rab6kifl
Domain Architecture
Description	Kinesin family member 20A (Rabkinesin-6) (Rab6-interacting kinesin- like protein) (Kinesin-like protein 174).

RNZ1_HUMAN
NC score	0.010760 (rank : 250)	θ value	5.27518 (rank : 204)
Query Neighborhood Hits	219	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H777, Q9NS99	Gene names	ELAC1, D29
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1) (Deleted in Ma29).

HRX_HUMAN
NC score	0.010249 (rank : 251)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	219	Target Neighborhood Hits	825	Shared Neighborhood Hits	25
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

INCE_MOUSE
NC score	0.009895 (rank : 252)	θ value	3.0926 (rank : 188)
Query Neighborhood Hits	219	Target Neighborhood Hits	903	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

IGLL1_MOUSE
NC score	0.009502 (rank : 253)	θ value	6.88961 (rank : 206)
Query Neighborhood Hits	219	Target Neighborhood Hits	196	Shared Neighborhood Hits	3
SwissProt Accessions	P20764, Q5W1K3	Gene names	Igll1, Igl-5
Domain Architecture	No domain graphic available
Description	Immunoglobulin lambda-like polypeptide 1 precursor (Ig lambda-5) (CD179b antigen).

NMDE4_MOUSE
NC score	0.008760 (rank : 254)	θ value	1.81305 (rank : 179)
Query Neighborhood Hits	219	Target Neighborhood Hits	158	Shared Neighborhood Hits	8
SwissProt Accessions	Q03391	Gene names	Grin2d
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D).

SON_MOUSE
NC score	0.008596 (rank : 255)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	219	Target Neighborhood Hits	957	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

NMDE4_HUMAN
NC score	0.008076 (rank : 256)	θ value	1.81305 (rank : 178)
Query Neighborhood Hits	219	Target Neighborhood Hits	133	Shared Neighborhood Hits	5
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

LETM1_MOUSE
NC score	0.006899 (rank : 257)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	219	Target Neighborhood Hits	240	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2I0, Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5	Gene names	Letm1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

ZFY16_HUMAN
NC score	0.006627 (rank : 258)	θ value	4.03905 (rank : 195)
Query Neighborhood Hits	219	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

VILI_MOUSE
NC score	0.006151 (rank : 259)	θ value	4.03905 (rank : 194)
Query Neighborhood Hits	219	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q62468, Q91WH4	Gene names	Vil1, Vil
Domain Architecture
Description	Villin-1.

VILI_HUMAN
NC score	0.005341 (rank : 260)	θ value	6.88961 (rank : 210)
Query Neighborhood Hits	219	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	P09327	Gene names	VIL1, VIL
Domain Architecture
Description	Villin-1.

DNM3A_HUMAN
NC score	0.004034 (rank : 261)	θ value	8.99809 (rank : 212)
Query Neighborhood Hits	219	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

CO4A2_MOUSE
NC score	0.001421 (rank : 262)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	219	Target Neighborhood Hits	492	Shared Neighborhood Hits	17
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CE005_HUMAN
NC score	0.001087 (rank : 263)	θ value	8.99809 (rank : 211)
Query Neighborhood Hits	219	Target Neighborhood Hits	213	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

MK06_MOUSE
NC score	0.000569 (rank : 264)	θ value	0.62314 (rank : 165)
Query Neighborhood Hits	219	Target Neighborhood Hits	818	Shared Neighborhood Hits	12
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

ZBT37_HUMAN
NC score	-0.005901 (rank : 265)	θ value	1.38821 (rank : 174)
Query Neighborhood Hits	219	Target Neighborhood Hits	815	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TC79, Q5TC80, Q96M87, Q9BQ88	Gene names	ZBTB37
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 37.