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Network neighborhood for query Sequence : MAGI1_MOUSE

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MAGI1_MOUSE
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MAGI1_HUMAN
θ value	0 (rank : 1)	NC score	0.985864 (rank : 2)
Query Neighborhood Hits	403	Target Neighborhood Hits	388	Shared Neighborhood Hits	312
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	403	Target Neighborhood Hits	403	Shared Neighborhood Hits	403
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	0 (rank : 3)	NC score	0.955359 (rank : 4)
Query Neighborhood Hits	403	Target Neighborhood Hits	373	Shared Neighborhood Hits	239
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	0 (rank : 4)	NC score	0.956035 (rank : 3)
Query Neighborhood Hits	403	Target Neighborhood Hits	370	Shared Neighborhood Hits	241
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MPDZ_HUMAN
θ value	5.59698e-26 (rank : 5)	NC score	0.730034 (rank : 5)
Query Neighborhood Hits	403	Target Neighborhood Hits	261	Shared Neighborhood Hits	202
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

INADL_MOUSE
θ value	5.79196e-23 (rank : 6)	NC score	0.725740 (rank : 6)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	202
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MPDZ_MOUSE
θ value	1.42661e-21 (rank : 7)	NC score	0.723935 (rank : 7)
Query Neighborhood Hits	403	Target Neighborhood Hits	298	Shared Neighborhood Hits	202
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

INADL_HUMAN
θ value	2.43343e-21 (rank : 8)	NC score	0.720126 (rank : 8)
Query Neighborhood Hits	403	Target Neighborhood Hits	260	Shared Neighborhood Hits	195
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

DLG4_HUMAN
θ value	1.92812e-18 (rank : 9)	NC score	0.652889 (rank : 29)
Query Neighborhood Hits	403	Target Neighborhood Hits	286	Shared Neighborhood Hits	185
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	2.5182e-18 (rank : 10)	NC score	0.653700 (rank : 27)
Query Neighborhood Hits	403	Target Neighborhood Hits	282	Shared Neighborhood Hits	187
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

PTN13_HUMAN
θ value	7.32683e-18 (rank : 11)	NC score	0.421729 (rank : 97)
Query Neighborhood Hits	403	Target Neighborhood Hits	471	Shared Neighborhood Hits	213
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PARD3_MOUSE
θ value	1.63225e-17 (rank : 12)	NC score	0.672367 (rank : 19)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	186
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

GRIP2_HUMAN
θ value	8.10077e-17 (rank : 13)	NC score	0.681224 (rank : 17)
Query Neighborhood Hits	403	Target Neighborhood Hits	256	Shared Neighborhood Hits	200
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

PTN13_MOUSE
θ value	1.058e-16 (rank : 14)	NC score	0.410271 (rank : 102)
Query Neighborhood Hits	403	Target Neighborhood Hits	426	Shared Neighborhood Hits	200
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

GRIP1_HUMAN
θ value	1.38178e-16 (rank : 15)	NC score	0.674045 (rank : 18)
Query Neighborhood Hits	403	Target Neighborhood Hits	231	Shared Neighborhood Hits	197
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

WWC1_HUMAN
θ value	4.02038e-16 (rank : 16)	NC score	0.388733 (rank : 110)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	4.02038e-16 (rank : 17)	NC score	0.386875 (rank : 111)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	51
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

PARD3_HUMAN
θ value	5.25075e-16 (rank : 18)	NC score	0.669693 (rank : 22)
Query Neighborhood Hits	403	Target Neighborhood Hits	312	Shared Neighborhood Hits	189
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PDZD1_MOUSE
θ value	1.16975e-15 (rank : 19)	NC score	0.671252 (rank : 20)
Query Neighborhood Hits	403	Target Neighborhood Hits	191	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

DLG3_MOUSE
θ value	1.52774e-15 (rank : 20)	NC score	0.646729 (rank : 31)
Query Neighborhood Hits	403	Target Neighborhood Hits	274	Shared Neighborhood Hits	183
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG3_HUMAN
θ value	4.44505e-15 (rank : 21)	NC score	0.644415 (rank : 33)
Query Neighborhood Hits	403	Target Neighborhood Hits	269	Shared Neighborhood Hits	183
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

LAP4_HUMAN
θ value	7.58209e-15 (rank : 22)	NC score	0.450594 (rank : 80)
Query Neighborhood Hits	403	Target Neighborhood Hits	608	Shared Neighborhood Hits	213
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

PDZD1_HUMAN
θ value	7.58209e-15 (rank : 23)	NC score	0.658541 (rank : 26)
Query Neighborhood Hits	403	Target Neighborhood Hits	190	Shared Neighborhood Hits	163
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

LAP4_MOUSE
θ value	1.68911e-14 (rank : 24)	NC score	0.442372 (rank : 83)
Query Neighborhood Hits	403	Target Neighborhood Hits	590	Shared Neighborhood Hits	206
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LNX2_MOUSE
θ value	1.09485e-13 (rank : 25)	NC score	0.623580 (rank : 43)
Query Neighborhood Hits	403	Target Neighborhood Hits	407	Shared Neighborhood Hits	184
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

NHRF2_HUMAN
θ value	1.42992e-13 (rank : 26)	NC score	0.648297 (rank : 30)
Query Neighborhood Hits	403	Target Neighborhood Hits	197	Shared Neighborhood Hits	175
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

DLG1_MOUSE
θ value	1.86753e-13 (rank : 27)	NC score	0.635719 (rank : 37)
Query Neighborhood Hits	403	Target Neighborhood Hits	285	Shared Neighborhood Hits	178
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG1_HUMAN
θ value	3.18553e-13 (rank : 28)	NC score	0.636638 (rank : 36)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	182
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG2_HUMAN
θ value	3.18553e-13 (rank : 29)	NC score	0.636851 (rank : 35)
Query Neighborhood Hits	403	Target Neighborhood Hits	279	Shared Neighborhood Hits	184
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

LNX1_HUMAN
θ value	3.18553e-13 (rank : 30)	NC score	0.615387 (rank : 48)
Query Neighborhood Hits	403	Target Neighborhood Hits	379	Shared Neighborhood Hits	174
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
θ value	3.18553e-13 (rank : 31)	NC score	0.622319 (rank : 44)
Query Neighborhood Hits	403	Target Neighborhood Hits	389	Shared Neighborhood Hits	183
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

DLG2_MOUSE
θ value	4.16044e-13 (rank : 32)	NC score	0.633676 (rank : 38)
Query Neighborhood Hits	403	Target Neighborhood Hits	271	Shared Neighborhood Hits	182
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

LNX1_MOUSE
θ value	4.16044e-13 (rank : 33)	NC score	0.617893 (rank : 46)
Query Neighborhood Hits	403	Target Neighborhood Hits	377	Shared Neighborhood Hits	182
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

WHRN_MOUSE
θ value	5.43371e-13 (rank : 34)	NC score	0.658774 (rank : 25)
Query Neighborhood Hits	403	Target Neighborhood Hits	412	Shared Neighborhood Hits	205
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

WWP2_HUMAN
θ value	7.09661e-13 (rank : 35)	NC score	0.311034 (rank : 149)
Query Neighborhood Hits	403	Target Neighborhood Hits	177	Shared Neighborhood Hits	68
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

SAV1_HUMAN
θ value	1.2105e-12 (rank : 36)	NC score	0.437349 (rank : 85)
Query Neighborhood Hits	403	Target Neighborhood Hits	51	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

GRIP1_MOUSE
θ value	1.58096e-12 (rank : 37)	NC score	0.666897 (rank : 23)
Query Neighborhood Hits	403	Target Neighborhood Hits	241	Shared Neighborhood Hits	198
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

ZO3_MOUSE
θ value	1.58096e-12 (rank : 38)	NC score	0.581689 (rank : 54)
Query Neighborhood Hits	403	Target Neighborhood Hits	224	Shared Neighborhood Hits	183
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

YAP1_MOUSE
θ value	2.0648e-12 (rank : 39)	NC score	0.401988 (rank : 103)
Query Neighborhood Hits	403	Target Neighborhood Hits	96	Shared Neighborhood Hits	52
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ZO3_HUMAN
θ value	2.0648e-12 (rank : 40)	NC score	0.575354 (rank : 56)
Query Neighborhood Hits	403	Target Neighborhood Hits	219	Shared Neighborhood Hits	177
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

LIN7C_HUMAN
θ value	2.69671e-12 (rank : 41)	NC score	0.713159 (rank : 11)
Query Neighborhood Hits	403	Target Neighborhood Hits	198	Shared Neighborhood Hits	190
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	2.69671e-12 (rank : 42)	NC score	0.713159 (rank : 12)
Query Neighborhood Hits	403	Target Neighborhood Hits	198	Shared Neighborhood Hits	190
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

SAV1_MOUSE
θ value	2.69671e-12 (rank : 43)	NC score	0.436515 (rank : 86)
Query Neighborhood Hits	403	Target Neighborhood Hits	48	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

LIN7B_HUMAN
θ value	4.59992e-12 (rank : 44)	NC score	0.714503 (rank : 9)
Query Neighborhood Hits	403	Target Neighborhood Hits	200	Shared Neighborhood Hits	190
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
θ value	6.00763e-12 (rank : 45)	NC score	0.713394 (rank : 10)
Query Neighborhood Hits	403	Target Neighborhood Hits	200	Shared Neighborhood Hits	190
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

NHRF2_MOUSE
θ value	7.84624e-12 (rank : 46)	NC score	0.639765 (rank : 34)
Query Neighborhood Hits	403	Target Neighborhood Hits	194	Shared Neighborhood Hits	175
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NHERF_MOUSE
θ value	1.02475e-11 (rank : 47)	NC score	0.645859 (rank : 32)
Query Neighborhood Hits	403	Target Neighborhood Hits	195	Shared Neighborhood Hits	168
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

WWP2_MOUSE
θ value	1.02475e-11 (rank : 48)	NC score	0.308926 (rank : 152)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

NEDD4_HUMAN
θ value	1.74796e-11 (rank : 49)	NC score	0.281108 (rank : 171)
Query Neighborhood Hits	403	Target Neighborhood Hits	214	Shared Neighborhood Hits	53
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

WHRN_HUMAN
θ value	1.74796e-11 (rank : 50)	NC score	0.660291 (rank : 24)
Query Neighborhood Hits	403	Target Neighborhood Hits	325	Shared Neighborhood Hits	203
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

PAR3L_HUMAN
θ value	3.89403e-11 (rank : 51)	NC score	0.653529 (rank : 28)
Query Neighborhood Hits	403	Target Neighborhood Hits	297	Shared Neighborhood Hits	164
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

K1849_HUMAN
θ value	6.64225e-11 (rank : 52)	NC score	0.528040 (rank : 66)
Query Neighborhood Hits	403	Target Neighborhood Hits	220	Shared Neighborhood Hits	145
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
θ value	8.67504e-11 (rank : 53)	NC score	0.507650 (rank : 72)
Query Neighborhood Hits	403	Target Neighborhood Hits	335	Shared Neighborhood Hits	153
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LIN7A_HUMAN
θ value	1.133e-10 (rank : 54)	NC score	0.708687 (rank : 15)
Query Neighborhood Hits	403	Target Neighborhood Hits	193	Shared Neighborhood Hits	189
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	1.133e-10 (rank : 55)	NC score	0.708852 (rank : 14)
Query Neighborhood Hits	403	Target Neighborhood Hits	193	Shared Neighborhood Hits	189
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

WWP1_HUMAN
θ value	1.133e-10 (rank : 56)	NC score	0.300761 (rank : 160)
Query Neighborhood Hits	403	Target Neighborhood Hits	262	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	1.47974e-10 (rank : 57)	NC score	0.303524 (rank : 156)
Query Neighborhood Hits	403	Target Neighborhood Hits	138	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_MOUSE
θ value	2.52405e-10 (rank : 58)	NC score	0.300213 (rank : 161)
Query Neighborhood Hits	403	Target Neighborhood Hits	127	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ZO1_MOUSE
θ value	2.52405e-10 (rank : 59)	NC score	0.525584 (rank : 67)
Query Neighborhood Hits	403	Target Neighborhood Hits	453	Shared Neighborhood Hits	200
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ITCH_HUMAN
θ value	3.29651e-10 (rank : 60)	NC score	0.297885 (rank : 162)
Query Neighborhood Hits	403	Target Neighborhood Hits	162	Shared Neighborhood Hits	53
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NHERF_HUMAN
θ value	5.62301e-10 (rank : 61)	NC score	0.628391 (rank : 39)
Query Neighborhood Hits	403	Target Neighborhood Hits	190	Shared Neighborhood Hits	165
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NED4L_HUMAN
θ value	7.34386e-10 (rank : 62)	NC score	0.274338 (rank : 174)
Query Neighborhood Hits	403	Target Neighborhood Hits	238	Shared Neighborhood Hits	56
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	7.34386e-10 (rank : 63)	NC score	0.274723 (rank : 173)
Query Neighborhood Hits	403	Target Neighborhood Hits	231	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PZRN4_HUMAN
θ value	9.59137e-10 (rank : 64)	NC score	0.517826 (rank : 71)
Query Neighborhood Hits	403	Target Neighborhood Hits	438	Shared Neighborhood Hits	159
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

IL16_HUMAN
θ value	1.63604e-09 (rank : 65)	NC score	0.615600 (rank : 47)
Query Neighborhood Hits	403	Target Neighborhood Hits	207	Shared Neighborhood Hits	148
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

SYJ2B_HUMAN
θ value	2.79066e-09 (rank : 66)	NC score	0.712125 (rank : 13)
Query Neighborhood Hits	403	Target Neighborhood Hits	162	Shared Neighborhood Hits	159
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

USH1C_HUMAN
θ value	2.79066e-09 (rank : 67)	NC score	0.670139 (rank : 21)
Query Neighborhood Hits	403	Target Neighborhood Hits	327	Shared Neighborhood Hits	195
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PDZD2_HUMAN
θ value	3.64472e-09 (rank : 68)	NC score	0.618998 (rank : 45)
Query Neighborhood Hits	403	Target Neighborhood Hits	772	Shared Neighborhood Hits	222
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SMUF2_HUMAN
θ value	3.64472e-09 (rank : 69)	NC score	0.285129 (rank : 169)
Query Neighborhood Hits	403	Target Neighborhood Hits	142	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SNTG1_HUMAN
θ value	3.64472e-09 (rank : 70)	NC score	0.575287 (rank : 57)
Query Neighborhood Hits	403	Target Neighborhood Hits	181	Shared Neighborhood Hits	175
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

ZO1_HUMAN
θ value	3.64472e-09 (rank : 71)	NC score	0.520105 (rank : 70)
Query Neighborhood Hits	403	Target Neighborhood Hits	474	Shared Neighborhood Hits	196
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTG1_MOUSE
θ value	4.76016e-09 (rank : 72)	NC score	0.574307 (rank : 58)
Query Neighborhood Hits	403	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SMUF1_HUMAN
θ value	6.21693e-09 (rank : 73)	NC score	0.273165 (rank : 176)
Query Neighborhood Hits	403	Target Neighborhood Hits	135	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

NEDD4_MOUSE
θ value	8.11959e-09 (rank : 74)	NC score	0.273448 (rank : 175)
Query Neighborhood Hits	403	Target Neighborhood Hits	212	Shared Neighborhood Hits	54
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PDZD7_HUMAN
θ value	8.11959e-09 (rank : 75)	NC score	0.699242 (rank : 16)
Query Neighborhood Hits	403	Target Neighborhood Hits	181	Shared Neighborhood Hits	172
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

SMUF1_MOUSE
θ value	1.06045e-08 (rank : 76)	NC score	0.282924 (rank : 170)
Query Neighborhood Hits	403	Target Neighborhood Hits	142	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

USH1C_MOUSE
θ value	2.36244e-08 (rank : 77)	NC score	0.625317 (rank : 42)
Query Neighborhood Hits	403	Target Neighborhood Hits	557	Shared Neighborhood Hits	209
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

SNTG2_HUMAN
θ value	3.08544e-08 (rank : 78)	NC score	0.597688 (rank : 51)
Query Neighborhood Hits	403	Target Neighborhood Hits	191	Shared Neighborhood Hits	183
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

IL16_MOUSE
θ value	8.97725e-08 (rank : 79)	NC score	0.584258 (rank : 53)
Query Neighborhood Hits	403	Target Neighborhood Hits	189	Shared Neighborhood Hits	146
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

SNTA1_HUMAN
θ value	8.97725e-08 (rank : 80)	NC score	0.559688 (rank : 64)
Query Neighborhood Hits	403	Target Neighborhood Hits	186	Shared Neighborhood Hits	169
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

GOPC_HUMAN
θ value	2.61198e-07 (rank : 81)	NC score	0.602613 (rank : 50)
Query Neighborhood Hits	403	Target Neighborhood Hits	377	Shared Neighborhood Hits	179
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	2.61198e-07 (rank : 82)	NC score	0.612127 (rank : 49)
Query Neighborhood Hits	403	Target Neighborhood Hits	323	Shared Neighborhood Hits	177
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

PZRN3_MOUSE
θ value	2.61198e-07 (rank : 83)	NC score	0.492420 (rank : 74)
Query Neighborhood Hits	403	Target Neighborhood Hits	447	Shared Neighborhood Hits	161
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

WWOX_HUMAN
θ value	2.61198e-07 (rank : 84)	NC score	0.268104 (rank : 177)
Query Neighborhood Hits	403	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	2.61198e-07 (rank : 85)	NC score	0.265702 (rank : 178)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

EM55_HUMAN
θ value	7.59969e-07 (rank : 86)	NC score	0.400018 (rank : 105)
Query Neighborhood Hits	403	Target Neighborhood Hits	228	Shared Neighborhood Hits	132
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SNTB2_HUMAN
θ value	9.92553e-07 (rank : 87)	NC score	0.561483 (rank : 62)
Query Neighborhood Hits	403	Target Neighborhood Hits	180	Shared Neighborhood Hits	163
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

PZRN3_HUMAN
θ value	1.29631e-06 (rank : 88)	NC score	0.489362 (rank : 76)
Query Neighborhood Hits	403	Target Neighborhood Hits	461	Shared Neighborhood Hits	162
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SNTB2_MOUSE
θ value	1.29631e-06 (rank : 89)	NC score	0.561059 (rank : 63)
Query Neighborhood Hits	403	Target Neighborhood Hits	181	Shared Neighborhood Hits	163
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

PDZD3_HUMAN
θ value	1.69304e-06 (rank : 90)	NC score	0.596389 (rank : 52)
Query Neighborhood Hits	403	Target Neighborhood Hits	180	Shared Neighborhood Hits	168
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PDLI2_MOUSE
θ value	2.21117e-06 (rank : 91)	NC score	0.445358 (rank : 82)
Query Neighborhood Hits	403	Target Neighborhood Hits	220	Shared Neighborhood Hits	124
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

SNTA1_MOUSE
θ value	2.21117e-06 (rank : 92)	NC score	0.550215 (rank : 65)
Query Neighborhood Hits	403	Target Neighborhood Hits	170	Shared Neighborhood Hits	163
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

PDLI5_MOUSE
θ value	2.88788e-06 (rank : 93)	NC score	0.262127 (rank : 179)
Query Neighborhood Hits	403	Target Neighborhood Hits	287	Shared Neighborhood Hits	119
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PKHA5_HUMAN
θ value	2.88788e-06 (rank : 94)	NC score	0.226340 (rank : 189)
Query Neighborhood Hits	403	Target Neighborhood Hits	455	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RGS12_HUMAN
θ value	2.88788e-06 (rank : 95)	NC score	0.305228 (rank : 155)
Query Neighborhood Hits	403	Target Neighborhood Hits	333	Shared Neighborhood Hits	141
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

SNTG2_MOUSE
θ value	2.88788e-06 (rank : 96)	NC score	0.564675 (rank : 61)
Query Neighborhood Hits	403	Target Neighborhood Hits	176	Shared Neighborhood Hits	171
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

STXB4_HUMAN
θ value	2.88788e-06 (rank : 97)	NC score	0.430304 (rank : 90)
Query Neighborhood Hits	403	Target Neighborhood Hits	616	Shared Neighborhood Hits	146
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

GRASP_MOUSE
θ value	3.77169e-06 (rank : 98)	NC score	0.455015 (rank : 78)
Query Neighborhood Hits	403	Target Neighborhood Hits	131	Shared Neighborhood Hits	118
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

APBA3_HUMAN
θ value	4.92598e-06 (rank : 99)	NC score	0.436246 (rank : 87)
Query Neighborhood Hits	403	Target Neighborhood Hits	201	Shared Neighborhood Hits	148
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA3_MOUSE
θ value	6.43352e-06 (rank : 100)	NC score	0.421683 (rank : 98)
Query Neighborhood Hits	403	Target Neighborhood Hits	174	Shared Neighborhood Hits	137
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

LDB3_MOUSE
θ value	6.43352e-06 (rank : 101)	NC score	0.260655 (rank : 181)
Query Neighborhood Hits	403	Target Neighborhood Hits	510	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

PDLI5_HUMAN
θ value	6.43352e-06 (rank : 102)	NC score	0.261013 (rank : 180)
Query Neighborhood Hits	403	Target Neighborhood Hits	322	Shared Neighborhood Hits	120
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

YAP1_HUMAN
θ value	6.43352e-06 (rank : 103)	NC score	0.309695 (rank : 151)
Query Neighborhood Hits	403	Target Neighborhood Hits	173	Shared Neighborhood Hits	54
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

AFAD_HUMAN
θ value	8.40245e-06 (rank : 104)	NC score	0.427624 (rank : 92)
Query Neighborhood Hits	403	Target Neighborhood Hits	689	Shared Neighborhood Hits	162
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

PDLI2_HUMAN
θ value	8.40245e-06 (rank : 105)	NC score	0.462699 (rank : 77)
Query Neighborhood Hits	403	Target Neighborhood Hits	245	Shared Neighborhood Hits	129
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDZD3_MOUSE
θ value	8.40245e-06 (rank : 106)	NC score	0.572555 (rank : 60)
Query Neighborhood Hits	403	Target Neighborhood Hits	171	Shared Neighborhood Hits	164
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

ARHGB_HUMAN
θ value	1.09739e-05 (rank : 107)	NC score	0.338315 (rank : 135)
Query Neighborhood Hits	403	Target Neighborhood Hits	375	Shared Neighborhood Hits	173
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

STXB4_MOUSE
θ value	1.09739e-05 (rank : 108)	NC score	0.424829 (rank : 95)
Query Neighborhood Hits	403	Target Neighborhood Hits	629	Shared Neighborhood Hits	143
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MAST1_HUMAN
θ value	1.43324e-05 (rank : 109)	NC score	0.082536 (rank : 260)
Query Neighborhood Hits	403	Target Neighborhood Hits	1146	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	1.43324e-05 (rank : 110)	NC score	0.083294 (rank : 257)
Query Neighborhood Hits	403	Target Neighborhood Hits	1123	Shared Neighborhood Hits	137
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

NIPBL_HUMAN
θ value	1.43324e-05 (rank : 111)	NC score	0.100274 (rank : 232)
Query Neighborhood Hits	403	Target Neighborhood Hits	1311	Shared Neighborhood Hits	120
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PDZ11_HUMAN
θ value	1.43324e-05 (rank : 112)	NC score	0.628108 (rank : 40)
Query Neighborhood Hits	403	Target Neighborhood Hits	160	Shared Neighborhood Hits	151
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	1.43324e-05 (rank : 113)	NC score	0.625833 (rank : 41)
Query Neighborhood Hits	403	Target Neighborhood Hits	154	Shared Neighborhood Hits	144
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

APBA1_HUMAN
θ value	1.87187e-05 (rank : 114)	NC score	0.431783 (rank : 88)
Query Neighborhood Hits	403	Target Neighborhood Hits	325	Shared Neighborhood Hits	167
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

DLG5_HUMAN
θ value	1.87187e-05 (rank : 115)	NC score	0.386058 (rank : 112)
Query Neighborhood Hits	403	Target Neighborhood Hits	1088	Shared Neighborhood Hits	202
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

MPP3_HUMAN
θ value	1.87187e-05 (rank : 116)	NC score	0.427580 (rank : 93)
Query Neighborhood Hits	403	Target Neighborhood Hits	171	Shared Neighborhood Hits	135
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	1.87187e-05 (rank : 117)	NC score	0.431689 (rank : 89)
Query Neighborhood Hits	403	Target Neighborhood Hits	165	Shared Neighborhood Hits	134
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

LDB3_HUMAN
θ value	2.44474e-05 (rank : 118)	NC score	0.258510 (rank : 182)
Query Neighborhood Hits	403	Target Neighborhood Hits	497	Shared Neighborhood Hits	118
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

MAST2_HUMAN
θ value	2.44474e-05 (rank : 119)	NC score	0.083874 (rank : 256)
Query Neighborhood Hits	403	Target Neighborhood Hits	1189	Shared Neighborhood Hits	145
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

NEB2_HUMAN
θ value	2.44474e-05 (rank : 120)	NC score	0.371942 (rank : 113)
Query Neighborhood Hits	403	Target Neighborhood Hits	883	Shared Neighborhood Hits	146
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	2.44474e-05 (rank : 121)	NC score	0.368946 (rank : 114)
Query Neighborhood Hits	403	Target Neighborhood Hits	889	Shared Neighborhood Hits	149
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PSCBP_MOUSE
θ value	2.44474e-05 (rank : 122)	NC score	0.438738 (rank : 84)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	113
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

GRASP_HUMAN
θ value	3.19293e-05 (rank : 123)	NC score	0.453675 (rank : 79)
Query Neighborhood Hits	403	Target Neighborhood Hits	147	Shared Neighborhood Hits	119
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

SYP2L_HUMAN
θ value	3.19293e-05 (rank : 124)	NC score	0.401156 (rank : 104)
Query Neighborhood Hits	403	Target Neighborhood Hits	400	Shared Neighborhood Hits	125
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

CSKP_HUMAN
θ value	4.1701e-05 (rank : 125)	NC score	0.139309 (rank : 219)
Query Neighborhood Hits	403	Target Neighborhood Hits	1022	Shared Neighborhood Hits	134
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	4.1701e-05 (rank : 126)	NC score	0.136061 (rank : 224)
Query Neighborhood Hits	403	Target Neighborhood Hits	1027	Shared Neighborhood Hits	133
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

EM55_MOUSE
θ value	4.1701e-05 (rank : 127)	NC score	0.393295 (rank : 108)
Query Neighborhood Hits	403	Target Neighborhood Hits	221	Shared Neighborhood Hits	130
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MY18A_MOUSE
θ value	4.1701e-05 (rank : 128)	NC score	0.094115 (rank : 237)
Query Neighborhood Hits	403	Target Neighborhood Hits	1989	Shared Neighborhood Hits	194
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PSCBP_HUMAN
θ value	4.1701e-05 (rank : 129)	NC score	0.424401 (rank : 96)
Query Neighborhood Hits	403	Target Neighborhood Hits	123	Shared Neighborhood Hits	115
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PTN3_HUMAN
θ value	4.1701e-05 (rank : 130)	NC score	0.166075 (rank : 205)
Query Neighborhood Hits	403	Target Neighborhood Hits	258	Shared Neighborhood Hits	117
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

SHAN1_HUMAN
θ value	4.1701e-05 (rank : 131)	NC score	0.219758 (rank : 194)
Query Neighborhood Hits	403	Target Neighborhood Hits	1041	Shared Neighborhood Hits	165
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

MPP8_HUMAN
θ value	5.44631e-05 (rank : 132)	NC score	0.047137 (rank : 315)
Query Neighborhood Hits	403	Target Neighborhood Hits	948	Shared Neighborhood Hits	72
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

SNTB1_HUMAN
θ value	5.44631e-05 (rank : 133)	NC score	0.524173 (rank : 68)
Query Neighborhood Hits	403	Target Neighborhood Hits	157	Shared Neighborhood Hits	152
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	5.44631e-05 (rank : 134)	NC score	0.520812 (rank : 69)
Query Neighborhood Hits	403	Target Neighborhood Hits	160	Shared Neighborhood Hits	150
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SYP2L_MOUSE
θ value	5.44631e-05 (rank : 135)	NC score	0.332320 (rank : 138)
Query Neighborhood Hits	403	Target Neighborhood Hits	289	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

MAST2_MOUSE
θ value	7.1131e-05 (rank : 136)	NC score	0.081795 (rank : 261)
Query Neighborhood Hits	403	Target Neighborhood Hits	1110	Shared Neighborhood Hits	141
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PDLI7_HUMAN
θ value	9.29e-05 (rank : 137)	NC score	0.247071 (rank : 185)
Query Neighborhood Hits	403	Target Neighborhood Hits	547	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDLI7_MOUSE
θ value	9.29e-05 (rank : 138)	NC score	0.237896 (rank : 188)
Query Neighborhood Hits	403	Target Neighborhood Hits	279	Shared Neighborhood Hits	103
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

WWTR1_MOUSE
θ value	9.29e-05 (rank : 139)	NC score	0.296441 (rank : 163)
Query Neighborhood Hits	403	Target Neighborhood Hits	54	Shared Neighborhood Hits	37
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

MPP5_HUMAN
θ value	0.000121331 (rank : 140)	NC score	0.428779 (rank : 91)
Query Neighborhood Hits	403	Target Neighborhood Hits	231	Shared Neighborhood Hits	141
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

NEB1_HUMAN
θ value	0.000121331 (rank : 141)	NC score	0.390963 (rank : 109)
Query Neighborhood Hits	403	Target Neighborhood Hits	829	Shared Neighborhood Hits	159
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

RGS3_HUMAN
θ value	0.000121331 (rank : 142)	NC score	0.104178 (rank : 228)
Query Neighborhood Hits	403	Target Neighborhood Hits	1375	Shared Neighborhood Hits	122
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

WWTR1_HUMAN
θ value	0.000121331 (rank : 143)	NC score	0.293597 (rank : 165)
Query Neighborhood Hits	403	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

MAST3_HUMAN
θ value	0.000158464 (rank : 144)	NC score	0.082901 (rank : 259)
Query Neighborhood Hits	403	Target Neighborhood Hits	1128	Shared Neighborhood Hits	138
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST4_HUMAN
θ value	0.000158464 (rank : 145)	NC score	0.087164 (rank : 253)
Query Neighborhood Hits	403	Target Neighborhood Hits	1804	Shared Neighborhood Hits	187
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MPP2_MOUSE
θ value	0.000158464 (rank : 146)	NC score	0.349666 (rank : 126)
Query Neighborhood Hits	403	Target Neighborhood Hits	189	Shared Neighborhood Hits	103
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP4_HUMAN
θ value	0.00020696 (rank : 147)	NC score	0.449465 (rank : 81)
Query Neighborhood Hits	403	Target Neighborhood Hits	205	Shared Neighborhood Hits	142
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

APBA2_HUMAN
θ value	0.000270298 (rank : 148)	NC score	0.413515 (rank : 101)
Query Neighborhood Hits	403	Target Neighborhood Hits	220	Shared Neighborhood Hits	155
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.000270298 (rank : 149)	NC score	0.413822 (rank : 100)
Query Neighborhood Hits	403	Target Neighborhood Hits	219	Shared Neighborhood Hits	156
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APXL_HUMAN
θ value	0.000270298 (rank : 150)	NC score	0.339531 (rank : 134)
Query Neighborhood Hits	403	Target Neighborhood Hits	553	Shared Neighborhood Hits	128
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARHGC_MOUSE
θ value	0.000270298 (rank : 151)	NC score	0.302280 (rank : 157)
Query Neighborhood Hits	403	Target Neighborhood Hits	344	Shared Neighborhood Hits	157
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MPP2_HUMAN
θ value	0.000270298 (rank : 152)	NC score	0.346132 (rank : 128)
Query Neighborhood Hits	403	Target Neighborhood Hits	173	Shared Neighborhood Hits	96
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP4_MOUSE
θ value	0.000270298 (rank : 153)	NC score	0.413897 (rank : 99)
Query Neighborhood Hits	403	Target Neighborhood Hits	188	Shared Neighborhood Hits	123
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP5_MOUSE
θ value	0.000270298 (rank : 154)	NC score	0.427000 (rank : 94)
Query Neighborhood Hits	403	Target Neighborhood Hits	226	Shared Neighborhood Hits	141
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

NOS1_MOUSE
θ value	0.000270298 (rank : 155)	NC score	0.256266 (rank : 184)
Query Neighborhood Hits	403	Target Neighborhood Hits	155	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

ARHGC_HUMAN
θ value	0.00035302 (rank : 156)	NC score	0.305993 (rank : 154)
Query Neighborhood Hits	403	Target Neighborhood Hits	351	Shared Neighborhood Hits	155
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MPP6_HUMAN
θ value	0.00035302 (rank : 157)	NC score	0.349202 (rank : 127)
Query Neighborhood Hits	403	Target Neighborhood Hits	180	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	0.00035302 (rank : 158)	NC score	0.353827 (rank : 122)
Query Neighborhood Hits	403	Target Neighborhood Hits	187	Shared Neighborhood Hits	100
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NPBL_MOUSE
θ value	0.00035302 (rank : 159)	NC score	0.103285 (rank : 229)
Query Neighborhood Hits	403	Target Neighborhood Hits	1041	Shared Neighborhood Hits	119
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

SYNP2_HUMAN
θ value	0.00035302 (rank : 160)	NC score	0.317546 (rank : 145)
Query Neighborhood Hits	403	Target Neighborhood Hits	323	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SFRS8_HUMAN
θ value	0.000461057 (rank : 161)	NC score	0.085378 (rank : 254)
Query Neighborhood Hits	403	Target Neighborhood Hits	166	Shared Neighborhood Hits	30
SwissProt Accessions	Q12872	Gene names	SFRS8, SWAP
Domain Architecture
Description	Splicing factor, arginine/serine-rich 8 (Suppressor of white apricot protein homolog).

LRRC7_HUMAN
θ value	0.000602161 (rank : 162)	NC score	0.223982 (rank : 191)
Query Neighborhood Hits	403	Target Neighborhood Hits	423	Shared Neighborhood Hits	123
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	0.000602161 (rank : 163)	NC score	0.222851 (rank : 192)
Query Neighborhood Hits	403	Target Neighborhood Hits	416	Shared Neighborhood Hits	119
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

RBBP6_MOUSE
θ value	0.000602161 (rank : 164)	NC score	0.092003 (rank : 244)
Query Neighborhood Hits	403	Target Neighborhood Hits	1014	Shared Neighborhood Hits	92
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

SYNP2_MOUSE
θ value	0.000602161 (rank : 165)	NC score	0.360644 (rank : 118)
Query Neighborhood Hits	403	Target Neighborhood Hits	252	Shared Neighborhood Hits	124
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

MY18A_HUMAN
θ value	0.000786445 (rank : 166)	NC score	0.084722 (rank : 255)
Query Neighborhood Hits	403	Target Neighborhood Hits	1929	Shared Neighborhood Hits	196
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NOS1_HUMAN
θ value	0.000786445 (rank : 167)	NC score	0.287820 (rank : 168)
Query Neighborhood Hits	403	Target Neighborhood Hits	218	Shared Neighborhood Hits	138
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PTN4_HUMAN
θ value	0.000786445 (rank : 168)	NC score	0.166323 (rank : 204)
Query Neighborhood Hits	403	Target Neighborhood Hits	303	Shared Neighborhood Hits	126
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

SHAN2_HUMAN
θ value	0.000786445 (rank : 169)	NC score	0.340369 (rank : 133)
Query Neighborhood Hits	403	Target Neighborhood Hits	346	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

TARA_HUMAN
θ value	0.000786445 (rank : 170)	NC score	0.090656 (rank : 245)
Query Neighborhood Hits	403	Target Neighborhood Hits	1626	Shared Neighborhood Hits	126
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PCLO_MOUSE
θ value	0.00102713 (rank : 171)	NC score	0.203868 (rank : 198)
Query Neighborhood Hits	403	Target Neighborhood Hits	2275	Shared Neighborhood Hits	226
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ZO2_HUMAN
θ value	0.00102713 (rank : 172)	NC score	0.497712 (rank : 73)
Query Neighborhood Hits	403	Target Neighborhood Hits	289	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

RHPN1_MOUSE
θ value	0.00134147 (rank : 173)	NC score	0.363339 (rank : 117)
Query Neighborhood Hits	403	Target Neighborhood Hits	154	Shared Neighborhood Hits	131
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SHAN2_MOUSE
θ value	0.00134147 (rank : 174)	NC score	0.306251 (rank : 153)
Query Neighborhood Hits	403	Target Neighborhood Hits	446	Shared Neighborhood Hits	132
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

CNKR2_HUMAN
θ value	0.00175202 (rank : 175)	NC score	0.206075 (rank : 197)
Query Neighborhood Hits	403	Target Neighborhood Hits	197	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.00175202 (rank : 176)	NC score	0.206241 (rank : 196)
Query Neighborhood Hits	403	Target Neighborhood Hits	197	Shared Neighborhood Hits	61
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

BAG3_HUMAN
θ value	0.00228821 (rank : 177)	NC score	0.240569 (rank : 187)
Query Neighborhood Hits	403	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

GIPC1_MOUSE
θ value	0.00228821 (rank : 178)	NC score	0.257529 (rank : 183)
Query Neighborhood Hits	403	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

KGUA_HUMAN
θ value	0.00228821 (rank : 179)	NC score	0.295297 (rank : 164)
Query Neighborhood Hits	403	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

TX1B3_HUMAN
θ value	0.00228821 (rank : 180)	NC score	0.575997 (rank : 55)
Query Neighborhood Hits	403	Target Neighborhood Hits	161	Shared Neighborhood Hits	153
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.00228821 (rank : 181)	NC score	0.572672 (rank : 59)
Query Neighborhood Hits	403	Target Neighborhood Hits	158	Shared Neighborhood Hits	150
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

KGUA_MOUSE
θ value	0.00298849 (rank : 182)	NC score	0.292185 (rank : 166)
Query Neighborhood Hits	403	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

PDLI3_HUMAN
θ value	0.00298849 (rank : 183)	NC score	0.324758 (rank : 142)
Query Neighborhood Hits	403	Target Neighborhood Hits	199	Shared Neighborhood Hits	108
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

RPGF2_HUMAN
θ value	0.00298849 (rank : 184)	NC score	0.301071 (rank : 159)
Query Neighborhood Hits	403	Target Neighborhood Hits	242	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	0.00298849 (rank : 185)	NC score	0.351231 (rank : 124)
Query Neighborhood Hits	403	Target Neighborhood Hits	266	Shared Neighborhood Hits	161
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

BAG3_MOUSE
θ value	0.00390308 (rank : 186)	NC score	0.221695 (rank : 193)
Query Neighborhood Hits	403	Target Neighborhood Hits	513	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PDLI1_HUMAN
θ value	0.00390308 (rank : 187)	NC score	0.310756 (rank : 150)
Query Neighborhood Hits	403	Target Neighborhood Hits	242	Shared Neighborhood Hits	101
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

RBBP6_HUMAN
θ value	0.00390308 (rank : 188)	NC score	0.100050 (rank : 233)
Query Neighborhood Hits	403	Target Neighborhood Hits	1135	Shared Neighborhood Hits	108
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

ZO2_MOUSE
θ value	0.00390308 (rank : 189)	NC score	0.492310 (rank : 75)
Query Neighborhood Hits	403	Target Neighborhood Hits	296	Shared Neighborhood Hits	189
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

DVL1_HUMAN
θ value	0.00509761 (rank : 190)	NC score	0.356190 (rank : 121)
Query Neighborhood Hits	403	Target Neighborhood Hits	158	Shared Neighborhood Hits	121
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

GIPC1_HUMAN
θ value	0.00509761 (rank : 191)	NC score	0.245337 (rank : 186)
Query Neighborhood Hits	403	Target Neighborhood Hits	91	Shared Neighborhood Hits	88
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

DVL1_MOUSE
θ value	0.00665767 (rank : 192)	NC score	0.352213 (rank : 123)
Query Neighborhood Hits	403	Target Neighborhood Hits	146	Shared Neighborhood Hits	117
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

PDLI4_HUMAN
θ value	0.00665767 (rank : 193)	NC score	0.316513 (rank : 146)
Query Neighborhood Hits	403	Target Neighborhood Hits	245	Shared Neighborhood Hits	111
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PICK1_HUMAN
θ value	0.00869519 (rank : 194)	NC score	0.396069 (rank : 107)
Query Neighborhood Hits	403	Target Neighborhood Hits	132	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	0.00869519 (rank : 195)	NC score	0.396948 (rank : 106)
Query Neighborhood Hits	403	Target Neighborhood Hits	131	Shared Neighborhood Hits	122
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

U2AFL_HUMAN
θ value	0.0113563 (rank : 196)	NC score	0.045564 (rank : 317)
Query Neighborhood Hits	403	Target Neighborhood Hits	503	Shared Neighborhood Hits	41
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

DDX46_HUMAN
θ value	0.0148317 (rank : 197)	NC score	0.029805 (rank : 351)
Query Neighborhood Hits	403	Target Neighborhood Hits	357	Shared Neighborhood Hits	46
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	0.0148317 (rank : 198)	NC score	0.030128 (rank : 349)
Query Neighborhood Hits	403	Target Neighborhood Hits	358	Shared Neighborhood Hits	48
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

PDZK4_HUMAN
θ value	0.0148317 (rank : 199)	NC score	0.368278 (rank : 115)
Query Neighborhood Hits	403	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

DVL1L_HUMAN
θ value	0.0193708 (rank : 200)	NC score	0.342752 (rank : 131)
Query Neighborhood Hits	403	Target Neighborhood Hits	146	Shared Neighborhood Hits	116
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL3_HUMAN
θ value	0.0193708 (rank : 201)	NC score	0.356941 (rank : 120)
Query Neighborhood Hits	403	Target Neighborhood Hits	194	Shared Neighborhood Hits	121
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.0193708 (rank : 202)	NC score	0.357834 (rank : 119)
Query Neighborhood Hits	403	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

LAP2_HUMAN
θ value	0.0193708 (rank : 203)	NC score	0.206890 (rank : 195)
Query Neighborhood Hits	403	Target Neighborhood Hits	499	Shared Neighborhood Hits	121
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	0.0193708 (rank : 204)	NC score	0.195264 (rank : 202)
Query Neighborhood Hits	403	Target Neighborhood Hits	482	Shared Neighborhood Hits	117
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PDLI1_MOUSE
θ value	0.0193708 (rank : 205)	NC score	0.315460 (rank : 147)
Query Neighborhood Hits	403	Target Neighborhood Hits	213	Shared Neighborhood Hits	102
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

SRRM2_HUMAN
θ value	0.0193708 (rank : 206)	NC score	0.108073 (rank : 227)
Query Neighborhood Hits	403	Target Neighborhood Hits	1296	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

PDLI3_MOUSE
θ value	0.0252991 (rank : 207)	NC score	0.302044 (rank : 158)
Query Neighborhood Hits	403	Target Neighborhood Hits	197	Shared Neighborhood Hits	104
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_MOUSE
θ value	0.0330416 (rank : 208)	NC score	0.313050 (rank : 148)
Query Neighborhood Hits	403	Target Neighborhood Hits	233	Shared Neighborhood Hits	114
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

U2AFM_HUMAN
θ value	0.0431538 (rank : 209)	NC score	0.047334 (rank : 313)
Query Neighborhood Hits	403	Target Neighborhood Hits	577	Shared Neighborhood Hits	46
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

ANK2_HUMAN
θ value	0.0563607 (rank : 210)	NC score	0.034399 (rank : 341)
Query Neighborhood Hits	403	Target Neighborhood Hits	1615	Shared Neighborhood Hits	117
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

APBB2_HUMAN
θ value	0.0563607 (rank : 211)	NC score	0.080961 (rank : 263)
Query Neighborhood Hits	403	Target Neighborhood Hits	96	Shared Neighborhood Hits	27
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

CCD55_HUMAN
θ value	0.0563607 (rank : 212)	NC score	0.076724 (rank : 267)
Query Neighborhood Hits	403	Target Neighborhood Hits	513	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H0G5, Q6FI71	Gene names	CCDC55
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 55.

PDZK4_MOUSE
θ value	0.0563607 (rank : 213)	NC score	0.366587 (rank : 116)
Query Neighborhood Hits	403	Target Neighborhood Hits	165	Shared Neighborhood Hits	131
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

DVL2_HUMAN
θ value	0.0736092 (rank : 214)	NC score	0.335322 (rank : 136)
Query Neighborhood Hits	403	Target Neighborhood Hits	223	Shared Neighborhood Hits	122
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	0.0736092 (rank : 215)	NC score	0.333905 (rank : 137)
Query Neighborhood Hits	403	Target Neighborhood Hits	233	Shared Neighborhood Hits	119
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

RIMS1_HUMAN
θ value	0.0961366 (rank : 216)	NC score	0.224093 (rank : 190)
Query Neighborhood Hits	403	Target Neighborhood Hits	437	Shared Neighborhood Hits	158
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

PAR6A_HUMAN
θ value	0.125558 (rank : 217)	NC score	0.329859 (rank : 140)
Query Neighborhood Hits	403	Target Neighborhood Hits	119	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6G_MOUSE
θ value	0.125558 (rank : 218)	NC score	0.350308 (rank : 125)
Query Neighborhood Hits	403	Target Neighborhood Hits	121	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

RHPN1_HUMAN
θ value	0.125558 (rank : 219)	NC score	0.320239 (rank : 143)
Query Neighborhood Hits	403	Target Neighborhood Hits	158	Shared Neighborhood Hits	126
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

CTRO_HUMAN
θ value	0.163984 (rank : 220)	NC score	0.018663 (rank : 387)
Query Neighborhood Hits	403	Target Neighborhood Hits	2092	Shared Neighborhood Hits	75
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MMTA2_MOUSE
θ value	0.163984 (rank : 221)	NC score	0.045341 (rank : 318)
Query Neighborhood Hits	403	Target Neighborhood Hits	40	Shared Neighborhood Hits	13
SwissProt Accessions	Q99LX5, Q9CSK6	Gene names	Mmtag2
Domain Architecture	No domain graphic available
Description	Multiple myeloma tumor-associated protein 2 homolog.

PAR6B_HUMAN
θ value	0.163984 (rank : 222)	NC score	0.343436 (rank : 129)
Query Neighborhood Hits	403	Target Neighborhood Hits	126	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	0.163984 (rank : 223)	NC score	0.343287 (rank : 130)
Query Neighborhood Hits	403	Target Neighborhood Hits	128	Shared Neighborhood Hits	121
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PTPRG_MOUSE
θ value	0.163984 (rank : 224)	NC score	0.025489 (rank : 360)
Query Neighborhood Hits	403	Target Neighborhood Hits	260	Shared Neighborhood Hits	13
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

TARA_MOUSE
θ value	0.163984 (rank : 225)	NC score	0.067088 (rank : 273)
Query Neighborhood Hits	403	Target Neighborhood Hits	1133	Shared Neighborhood Hits	93
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

THSD1_MOUSE
θ value	0.163984 (rank : 226)	NC score	0.021913 (rank : 374)
Query Neighborhood Hits	403	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

CAC1A_MOUSE
θ value	0.21417 (rank : 227)	NC score	0.020921 (rank : 378)
Query Neighborhood Hits	403	Target Neighborhood Hits	267	Shared Neighborhood Hits	35
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

DSG1_HUMAN
θ value	0.21417 (rank : 228)	NC score	0.002266 (rank : 432)
Query Neighborhood Hits	403	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q02413	Gene names	DSG1
Domain Architecture
Description	Desmoglein-1 precursor (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen).

SFR11_HUMAN
θ value	0.21417 (rank : 229)	NC score	0.081025 (rank : 262)
Query Neighborhood Hits	403	Target Neighborhood Hits	246	Shared Neighborhood Hits	53
SwissProt Accessions	Q05519	Gene names	SFRS11
Domain Architecture
Description	Splicing factor arginine/serine-rich 11 (Arginine-rich 54 kDa nuclear protein) (p54).

SFRIP_HUMAN
θ value	0.21417 (rank : 230)	NC score	0.079682 (rank : 264)
Query Neighborhood Hits	403	Target Neighborhood Hits	530	Shared Neighborhood Hits	68
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SRRM2_MOUSE
θ value	0.21417 (rank : 231)	NC score	0.097338 (rank : 236)
Query Neighborhood Hits	403	Target Neighborhood Hits	1470	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

BLNK_MOUSE
θ value	0.279714 (rank : 232)	NC score	0.030339 (rank : 347)
Query Neighborhood Hits	403	Target Neighborhood Hits	296	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

LAD1_HUMAN
θ value	0.279714 (rank : 233)	NC score	0.047938 (rank : 311)
Query Neighborhood Hits	403	Target Neighborhood Hits	441	Shared Neighborhood Hits	46
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

APBB3_HUMAN
θ value	0.365318 (rank : 234)	NC score	0.067395 (rank : 272)
Query Neighborhood Hits	403	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
θ value	0.365318 (rank : 235)	NC score	0.066115 (rank : 275)
Query Neighborhood Hits	403	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

MRP6_HUMAN
θ value	0.365318 (rank : 236)	NC score	0.010569 (rank : 408)
Query Neighborhood Hits	403	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	O95255, P78420, Q9UMZ7	Gene names	ABCC6, ARA, MRP6
Domain Architecture
Description	Multidrug resistance-associated protein 6 (ATP-binding cassette sub- family C member 6) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter-E) (MOAT-E).

NKTR_HUMAN
θ value	0.365318 (rank : 237)	NC score	0.043478 (rank : 323)
Query Neighborhood Hits	403	Target Neighborhood Hits	658	Shared Neighborhood Hits	81
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

RBM15_HUMAN
θ value	0.365318 (rank : 238)	NC score	0.035038 (rank : 340)
Query Neighborhood Hits	403	Target Neighborhood Hits	309	Shared Neighborhood Hits	38
SwissProt Accessions	Q96T37, Q5D058, Q96PE4, Q96SC5, Q96SC6, Q96SC9, Q96SD0, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0	Gene names	RBM15, OTT
Domain Architecture
Description	Putative RNA-binding protein 15 (RNA-binding motif protein 15) (One- twenty two protein).

RGS3_MOUSE
θ value	0.365318 (rank : 239)	NC score	0.093954 (rank : 238)
Query Neighborhood Hits	403	Target Neighborhood Hits	1621	Shared Neighborhood Hits	144
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TIAM1_HUMAN
θ value	0.365318 (rank : 240)	NC score	0.092942 (rank : 241)
Query Neighborhood Hits	403	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

LEO1_HUMAN
θ value	0.47712 (rank : 241)	NC score	0.040817 (rank : 326)
Query Neighborhood Hits	403	Target Neighborhood Hits	958	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

PAR6A_MOUSE
θ value	0.47712 (rank : 242)	NC score	0.332210 (rank : 139)
Query Neighborhood Hits	403	Target Neighborhood Hits	115	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6G_HUMAN
θ value	0.47712 (rank : 243)	NC score	0.342633 (rank : 132)
Query Neighborhood Hits	403	Target Neighborhood Hits	159	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

SFR12_MOUSE
θ value	0.47712 (rank : 244)	NC score	0.057451 (rank : 287)
Query Neighborhood Hits	403	Target Neighborhood Hits	486	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

SRRM1_HUMAN
θ value	0.47712 (rank : 245)	NC score	0.076984 (rank : 266)
Query Neighborhood Hits	403	Target Neighborhood Hits	690	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

CCD55_MOUSE
θ value	0.62314 (rank : 246)	NC score	0.074308 (rank : 270)
Query Neighborhood Hits	403	Target Neighborhood Hits	519	Shared Neighborhood Hits	76
SwissProt Accessions	Q5NCR9	Gene names	Ccdc55
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 55.

RIMS2_HUMAN
θ value	0.62314 (rank : 247)	NC score	0.196139 (rank : 201)
Query Neighborhood Hits	403	Target Neighborhood Hits	342	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	0.62314 (rank : 248)	NC score	0.198530 (rank : 200)
Query Neighborhood Hits	403	Target Neighborhood Hits	376	Shared Neighborhood Hits	143
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RPTN_MOUSE
θ value	0.62314 (rank : 249)	NC score	0.038882 (rank : 329)
Query Neighborhood Hits	403	Target Neighborhood Hits	650	Shared Neighborhood Hits	73
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

TGON2_HUMAN
θ value	0.62314 (rank : 250)	NC score	0.054329 (rank : 294)
Query Neighborhood Hits	403	Target Neighborhood Hits	1037	Shared Neighborhood Hits	99
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TIAM1_MOUSE
θ value	0.62314 (rank : 251)	NC score	0.065999 (rank : 276)
Query Neighborhood Hits	403	Target Neighborhood Hits	205	Shared Neighborhood Hits	54
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

AP2A_HUMAN
θ value	0.813845 (rank : 252)	NC score	0.021132 (rank : 377)
Query Neighborhood Hits	403	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P05549, Q13777	Gene names	TFAP2A, AP2TF, TFAP2
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (AP-2 transcription factor) (Activator protein 2) (AP-2).

AP2A_MOUSE
θ value	0.813845 (rank : 253)	NC score	0.020602 (rank : 380)
Query Neighborhood Hits	403	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	P34056, Q60740, Q60741, Q60742, Q60743, Q62067, Q62068, Q62069, Q91VX0, Q9CRY4	Gene names	Tfap2a, Ap2tf, Tcfap2a
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (Activator protein 2) (AP-2).

CN102_HUMAN
θ value	0.813845 (rank : 254)	NC score	0.023155 (rank : 368)
Query Neighborhood Hits	403	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H7Z3, Q9NWH6	Gene names	C14orf102
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf102.

EDAR_HUMAN
θ value	0.813845 (rank : 255)	NC score	0.022304 (rank : 371)
Query Neighborhood Hits	403	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

EDNRB_HUMAN
θ value	0.813845 (rank : 256)	NC score	-0.004493 (rank : 445)
Query Neighborhood Hits	403	Target Neighborhood Hits	598	Shared Neighborhood Hits	3
SwissProt Accessions	P24530, O15343, Q9UQK3	Gene names	EDNRB, ETRB
Domain Architecture
Description	Endothelin B receptor precursor (ET-B) (Endothelin receptor Non- selective type).

HRG_HUMAN
θ value	0.813845 (rank : 257)	NC score	0.040471 (rank : 327)
Query Neighborhood Hits	403	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	P04196	Gene names	HRG
Domain Architecture
Description	Histidine-rich glycoprotein precursor (Histidine-proline-rich glycoprotein) (HPRG).

LSR_HUMAN
θ value	0.813845 (rank : 258)	NC score	0.022869 (rank : 370)
Query Neighborhood Hits	403	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q86X29, O00112, O00426, Q6ZT80, Q9UQL3	Gene names	LSR, LISCH
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor.

PRR8_HUMAN
θ value	0.813845 (rank : 259)	NC score	0.044516 (rank : 321)
Query Neighborhood Hits	403	Target Neighborhood Hits	217	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

RPTN_HUMAN
θ value	0.813845 (rank : 260)	NC score	0.036033 (rank : 338)
Query Neighborhood Hits	403	Target Neighborhood Hits	406	Shared Neighborhood Hits	55
SwissProt Accessions	Q6XPR3	Gene names	RPTN
Domain Architecture	No domain graphic available
Description	Repetin.

TF3C1_MOUSE
θ value	0.813845 (rank : 261)	NC score	0.027483 (rank : 355)
Query Neighborhood Hits	403	Target Neighborhood Hits	92	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K284, Q8CAL9	Gene names	Gtf3c1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

TOP1_MOUSE
θ value	0.813845 (rank : 262)	NC score	0.032450 (rank : 345)
Query Neighborhood Hits	403	Target Neighborhood Hits	213	Shared Neighborhood Hits	32
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

TRIPC_HUMAN
θ value	0.813845 (rank : 263)	NC score	0.150759 (rank : 211)
Query Neighborhood Hits	403	Target Neighborhood Hits	319	Shared Neighborhood Hits	56
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

CD2L1_HUMAN
θ value	1.06291 (rank : 264)	NC score	0.010965 (rank : 407)
Query Neighborhood Hits	403	Target Neighborhood Hits	1467	Shared Neighborhood Hits	65
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

DLGP3_HUMAN
θ value	1.06291 (rank : 265)	NC score	0.012708 (rank : 399)
Query Neighborhood Hits	403	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	O95886, Q5TDD5, Q9H3X7	Gene names	DLGAP3, DAP3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

FILA_HUMAN
θ value	1.06291 (rank : 266)	NC score	0.054041 (rank : 296)
Query Neighborhood Hits	403	Target Neighborhood Hits	685	Shared Neighborhood Hits	86
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

GIPC3_HUMAN
θ value	1.06291 (rank : 267)	NC score	0.153378 (rank : 209)
Query Neighborhood Hits	403	Target Neighborhood Hits	52	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	1.06291 (rank : 268)	NC score	0.145269 (rank : 216)
Query Neighborhood Hits	403	Target Neighborhood Hits	53	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

MTR1L_MOUSE
θ value	1.06291 (rank : 269)	NC score	-0.006955 (rank : 447)
Query Neighborhood Hits	403	Target Neighborhood Hits	903	Shared Neighborhood Hits	5
SwissProt Accessions	O88495	Gene names	Gpr50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

NOL3_HUMAN
θ value	1.06291 (rank : 270)	NC score	0.038064 (rank : 330)
Query Neighborhood Hits	403	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	O60936, O60937	Gene names	NOL3, ARC, NOP
Domain Architecture
Description	Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30).

PHF20_MOUSE
θ value	1.06291 (rank : 271)	NC score	0.033263 (rank : 342)
Query Neighborhood Hits	403	Target Neighborhood Hits	513	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

TRDN_HUMAN
θ value	1.06291 (rank : 272)	NC score	0.045047 (rank : 319)
Query Neighborhood Hits	403	Target Neighborhood Hits	542	Shared Neighborhood Hits	53
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

VINEX_MOUSE
θ value	1.06291 (rank : 273)	NC score	0.010114 (rank : 409)
Query Neighborhood Hits	403	Target Neighborhood Hits	286	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WASF3_MOUSE
θ value	1.06291 (rank : 274)	NC score	0.017586 (rank : 388)
Query Neighborhood Hits	403	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

WWC3_HUMAN
θ value	1.06291 (rank : 275)	NC score	0.087666 (rank : 252)
Query Neighborhood Hits	403	Target Neighborhood Hits	193	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

BAT2_HUMAN
θ value	1.38821 (rank : 276)	NC score	0.047690 (rank : 312)
Query Neighborhood Hits	403	Target Neighborhood Hits	931	Shared Neighborhood Hits	72
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BTBD7_HUMAN
θ value	1.38821 (rank : 277)	NC score	0.017558 (rank : 390)
Query Neighborhood Hits	403	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P203, Q69Z05, Q7Z308, Q86TS0, Q9HAA4, Q9NVM0	Gene names	BTBD7, KIAA1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

CD2L1_MOUSE
θ value	1.38821 (rank : 278)	NC score	0.010037 (rank : 410)
Query Neighborhood Hits	403	Target Neighborhood Hits	1463	Shared Neighborhood Hits	70
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

COA2_HUMAN
θ value	1.38821 (rank : 279)	NC score	0.019649 (rank : 383)
Query Neighborhood Hits	403	Target Neighborhood Hits	184	Shared Neighborhood Hits	25
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

CROCC_MOUSE
θ value	1.38821 (rank : 280)	NC score	0.022904 (rank : 369)
Query Neighborhood Hits	403	Target Neighborhood Hits	1460	Shared Neighborhood Hits	76
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

GBRD_HUMAN
θ value	1.38821 (rank : 281)	NC score	0.001515 (rank : 437)
Query Neighborhood Hits	403	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	O14764, Q8N4N9	Gene names	GABRD
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit delta precursor (GABA(A) receptor subunit delta).

NEK3_HUMAN
θ value	1.38821 (rank : 282)	NC score	0.004500 (rank : 427)
Query Neighborhood Hits	403	Target Neighborhood Hits	865	Shared Neighborhood Hits	21
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

PIN1_HUMAN
θ value	1.38821 (rank : 283)	NC score	0.165125 (rank : 207)
Query Neighborhood Hits	403	Target Neighborhood Hits	59	Shared Neighborhood Hits	38
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	1.38821 (rank : 284)	NC score	0.165911 (rank : 206)
Query Neighborhood Hits	403	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

ZEP1_HUMAN
θ value	1.38821 (rank : 285)	NC score	-0.001508 (rank : 443)
Query Neighborhood Hits	403	Target Neighborhood Hits	1036	Shared Neighborhood Hits	30
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

CCNK_MOUSE
θ value	1.81305 (rank : 286)	NC score	0.025731 (rank : 359)
Query Neighborhood Hits	403	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

CHD6_HUMAN
θ value	1.81305 (rank : 287)	NC score	0.008679 (rank : 413)
Query Neighborhood Hits	403	Target Neighborhood Hits	342	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

DEK_MOUSE
θ value	1.81305 (rank : 288)	NC score	0.047234 (rank : 314)
Query Neighborhood Hits	403	Target Neighborhood Hits	280	Shared Neighborhood Hits	31
SwissProt Accessions	Q7TNV0, Q80VC5, Q8BZV6	Gene names	Dek
Domain Architecture	No domain graphic available
Description	Protein DEK.

DMD_HUMAN
θ value	1.81305 (rank : 289)	NC score	0.029255 (rank : 353)
Query Neighborhood Hits	403	Target Neighborhood Hits	1135	Shared Neighborhood Hits	60
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	1.81305 (rank : 290)	NC score	0.028509 (rank : 354)
Query Neighborhood Hits	403	Target Neighborhood Hits	1111	Shared Neighborhood Hits	68
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

KTNA1_MOUSE
θ value	1.81305 (rank : 291)	NC score	0.003376 (rank : 431)
Query Neighborhood Hits	403	Target Neighborhood Hits	123	Shared Neighborhood Hits	11
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

LIMK2_MOUSE
θ value	1.81305 (rank : 292)	NC score	0.029988 (rank : 350)
Query Neighborhood Hits	403	Target Neighborhood Hits	998	Shared Neighborhood Hits	76
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RECQ5_HUMAN
θ value	1.81305 (rank : 293)	NC score	0.021991 (rank : 373)
Query Neighborhood Hits	403	Target Neighborhood Hits	390	Shared Neighborhood Hits	34
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

SDCB1_HUMAN
θ value	1.81305 (rank : 294)	NC score	0.319176 (rank : 144)
Query Neighborhood Hits	403	Target Neighborhood Hits	150	Shared Neighborhood Hits	142
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	1.81305 (rank : 295)	NC score	0.328185 (rank : 141)
Query Neighborhood Hits	403	Target Neighborhood Hits	144	Shared Neighborhood Hits	134
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SETD2_HUMAN
θ value	1.81305 (rank : 296)	NC score	0.079282 (rank : 265)
Query Neighborhood Hits	403	Target Neighborhood Hits	412	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SI1L2_HUMAN
θ value	1.81305 (rank : 297)	NC score	0.059815 (rank : 282)
Query Neighborhood Hits	403	Target Neighborhood Hits	131	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
θ value	1.81305 (rank : 298)	NC score	0.058690 (rank : 284)
Query Neighborhood Hits	403	Target Neighborhood Hits	124	Shared Neighborhood Hits	45
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L3_HUMAN
θ value	1.81305 (rank : 299)	NC score	0.056420 (rank : 289)
Query Neighborhood Hits	403	Target Neighborhood Hits	305	Shared Neighborhood Hits	58
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

TRM1_HUMAN
θ value	1.81305 (rank : 300)	NC score	0.026347 (rank : 356)
Query Neighborhood Hits	403	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXH9, O76103, Q548Y5, Q8WVA6	Gene names	TRMT1
Domain Architecture
Description	N(2),N(2)-dimethylguanosine tRNA methyltransferase (EC 2.1.1.32) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA 2,2- dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase).

BACH1_MOUSE
θ value	2.36792 (rank : 301)	NC score	0.001938 (rank : 434)
Query Neighborhood Hits	403	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	P97302	Gene names	Bach1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1).

GIPC2_MOUSE
θ value	2.36792 (rank : 302)	NC score	0.145714 (rank : 215)
Query Neighborhood Hits	403	Target Neighborhood Hits	71	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

MLL2_HUMAN
θ value	2.36792 (rank : 303)	NC score	0.030188 (rank : 348)
Query Neighborhood Hits	403	Target Neighborhood Hits	1788	Shared Neighborhood Hits	87
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MRIP_MOUSE
θ value	2.36792 (rank : 304)	NC score	0.036113 (rank : 337)
Query Neighborhood Hits	403	Target Neighborhood Hits	569	Shared Neighborhood Hits	29
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

RHG12_MOUSE
θ value	2.36792 (rank : 305)	NC score	0.051100 (rank : 306)
Query Neighborhood Hits	403	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SDCB2_HUMAN
θ value	2.36792 (rank : 306)	NC score	0.276827 (rank : 172)
Query Neighborhood Hits	403	Target Neighborhood Hits	121	Shared Neighborhood Hits	115
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SHD_HUMAN
θ value	2.36792 (rank : 307)	NC score	0.011538 (rank : 405)
Query Neighborhood Hits	403	Target Neighborhood Hits	204	Shared Neighborhood Hits	7
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

TCRG1_MOUSE
θ value	2.36792 (rank : 308)	NC score	0.053309 (rank : 298)
Query Neighborhood Hits	403	Target Neighborhood Hits	947	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TR150_MOUSE
θ value	2.36792 (rank : 309)	NC score	0.037938 (rank : 331)
Query Neighborhood Hits	403	Target Neighborhood Hits	468	Shared Neighborhood Hits	63
SwissProt Accessions	Q569Z6	Gene names	Thrap3, Trap150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

A2BP1_HUMAN
θ value	3.0926 (rank : 310)	NC score	0.013695 (rank : 395)
Query Neighborhood Hits	403	Target Neighborhood Hits	229	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NWB1, Q9NS20	Gene names	A2BP1, A2BP
Domain Architecture
Description	Ataxin-2-binding protein 1.

CENPT_MOUSE
θ value	3.0926 (rank : 311)	NC score	0.024484 (rank : 362)
Query Neighborhood Hits	403	Target Neighborhood Hits	115	Shared Neighborhood Hits	16
SwissProt Accessions	Q3TJM4, Q3TPY6, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9	Gene names	Cenpt
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T).

CIR_HUMAN
θ value	3.0926 (rank : 312)	NC score	0.051291 (rank : 305)
Query Neighborhood Hits	403	Target Neighborhood Hits	249	Shared Neighborhood Hits	42
SwissProt Accessions	Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2	Gene names	CIR
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor (Recepin).

CROP_HUMAN
θ value	3.0926 (rank : 313)	NC score	0.041761 (rank : 325)
Query Neighborhood Hits	403	Target Neighborhood Hits	402	Shared Neighborhood Hits	46
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

DMN_HUMAN
θ value	3.0926 (rank : 314)	NC score	0.019193 (rank : 384)
Query Neighborhood Hits	403	Target Neighborhood Hits	690	Shared Neighborhood Hits	58
SwissProt Accessions	O15061	Gene names	DMN, KIAA0353
Domain Architecture
Description	Desmuslin.

DNMT1_MOUSE
θ value	3.0926 (rank : 315)	NC score	0.017174 (rank : 391)
Query Neighborhood Hits	403	Target Neighborhood Hits	137	Shared Neighborhood Hits	16
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

GRPE1_MOUSE
θ value	3.0926 (rank : 316)	NC score	0.012103 (rank : 403)
Query Neighborhood Hits	403	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q99LP6, Q3TSZ3	Gene names	Grpel1
Domain Architecture	No domain graphic available
Description	GrpE protein homolog 1, mitochondrial precursor (Mt-GrpE#1).

HHEX_HUMAN
θ value	3.0926 (rank : 317)	NC score	0.000303 (rank : 440)
Query Neighborhood Hits	403	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	Q03014	Gene names	HHEX, HEX, PRH, PRHX
Domain Architecture
Description	Homeobox protein PRH (Hematopoietically expressed homeobox) (Homeobox protein HEX).

HTRA1_MOUSE
θ value	3.0926 (rank : 318)	NC score	0.055808 (rank : 290)
Query Neighborhood Hits	403	Target Neighborhood Hits	140	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

LEG9_MOUSE
θ value	3.0926 (rank : 319)	NC score	0.006805 (rank : 418)
Query Neighborhood Hits	403	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	O08573, O08572	Gene names	Lgals9
Domain Architecture
Description	Galectin-9.

MRCKB_MOUSE
θ value	3.0926 (rank : 320)	NC score	0.016337 (rank : 394)
Query Neighborhood Hits	403	Target Neighborhood Hits	2180	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PCBP3_HUMAN
θ value	3.0926 (rank : 321)	NC score	0.012337 (rank : 402)
Query Neighborhood Hits	403	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	P57721, Q8N9K6, Q96EP6	Gene names	PCBP3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

PCBP3_MOUSE
θ value	3.0926 (rank : 322)	NC score	0.012340 (rank : 401)
Query Neighborhood Hits	403	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	P57722, Q8BSB0, Q8C544	Gene names	Pcbp3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

PGCA_HUMAN
θ value	3.0926 (rank : 323)	NC score	0.006536 (rank : 419)
Query Neighborhood Hits	403	Target Neighborhood Hits	821	Shared Neighborhood Hits	31
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

PINL_HUMAN
θ value	3.0926 (rank : 324)	NC score	0.185485 (rank : 203)
Query Neighborhood Hits	403	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

TXND2_MOUSE
θ value	3.0926 (rank : 325)	NC score	0.037367 (rank : 334)
Query Neighborhood Hits	403	Target Neighborhood Hits	828	Shared Neighborhood Hits	77
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

TXND4_MOUSE
θ value	3.0926 (rank : 326)	NC score	0.008481 (rank : 415)
Query Neighborhood Hits	403	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D1Q6, Q3TVI1, Q6A045	Gene names	Txndc4, Erp44, Kiaa0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

ZN575_HUMAN
θ value	3.0926 (rank : 327)	NC score	-0.010476 (rank : 448)
Query Neighborhood Hits	403	Target Neighborhood Hits	739	Shared Neighborhood Hits	9
SwissProt Accessions	Q86XF7	Gene names	ZNF575
Domain Architecture	No domain graphic available
Description	Zinc finger protein 575.

ACINU_HUMAN
θ value	4.03905 (rank : 328)	NC score	0.044482 (rank : 322)
Query Neighborhood Hits	403	Target Neighborhood Hits	828	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

AP3B2_HUMAN
θ value	4.03905 (rank : 329)	NC score	0.013149 (rank : 396)
Query Neighborhood Hits	403	Target Neighborhood Hits	246	Shared Neighborhood Hits	32
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

BSPRY_MOUSE
θ value	4.03905 (rank : 330)	NC score	0.009586 (rank : 411)
Query Neighborhood Hits	403	Target Neighborhood Hits	163	Shared Neighborhood Hits	11
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

COHA1_HUMAN
θ value	4.03905 (rank : 331)	NC score	0.017076 (rank : 392)
Query Neighborhood Hits	403	Target Neighborhood Hits	400	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CSPG3_MOUSE
θ value	4.03905 (rank : 332)	NC score	0.000309 (rank : 439)
Query Neighborhood Hits	403	Target Neighborhood Hits	657	Shared Neighborhood Hits	24
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CTRO_MOUSE
θ value	4.03905 (rank : 333)	NC score	0.019088 (rank : 385)
Query Neighborhood Hits	403	Target Neighborhood Hits	2344	Shared Neighborhood Hits	91
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

IF3A_MOUSE
θ value	4.03905 (rank : 334)	NC score	0.022052 (rank : 372)
Query Neighborhood Hits	403	Target Neighborhood Hits	871	Shared Neighborhood Hits	58
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

LIMK1_HUMAN
θ value	4.03905 (rank : 335)	NC score	0.037489 (rank : 333)
Query Neighborhood Hits	403	Target Neighborhood Hits	1005	Shared Neighborhood Hits	87
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	4.03905 (rank : 336)	NC score	0.037579 (rank : 332)
Query Neighborhood Hits	403	Target Neighborhood Hits	1008	Shared Neighborhood Hits	88
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

MCES_HUMAN
θ value	4.03905 (rank : 337)	NC score	0.021251 (rank : 376)
Query Neighborhood Hits	403	Target Neighborhood Hits	134	Shared Neighborhood Hits	19
SwissProt Accessions	O43148, O94996, Q9UIJ9	Gene names	RNMT, KIAA0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase) (hcm1p) (hCMT1) (hMet).

MYEF2_HUMAN
θ value	4.03905 (rank : 338)	NC score	0.003700 (rank : 430)
Query Neighborhood Hits	403	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P2K5, Q6NUM5, Q7L388, Q7Z4B7, Q9H922, Q9NUQ1	Gene names	MYEF2, KIAA1341
Domain Architecture	No domain graphic available
Description	Myelin expression factor 2 (MyEF-2) (MST156).

PO6F2_MOUSE
θ value	4.03905 (rank : 339)	NC score	0.018819 (rank : 386)
Query Neighborhood Hits	403	Target Neighborhood Hits	639	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

RRBP1_HUMAN
θ value	4.03905 (rank : 340)	NC score	0.021784 (rank : 375)
Query Neighborhood Hits	403	Target Neighborhood Hits	1306	Shared Neighborhood Hits	78
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

SDCB2_MOUSE
θ value	4.03905 (rank : 341)	NC score	0.290232 (rank : 167)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	111
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SRRM1_MOUSE
θ value	4.03905 (rank : 342)	NC score	0.083227 (rank : 258)
Query Neighborhood Hits	403	Target Neighborhood Hits	966	Shared Neighborhood Hits	107
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

YLPM1_HUMAN
θ value	4.03905 (rank : 343)	NC score	0.042395 (rank : 324)
Query Neighborhood Hits	403	Target Neighborhood Hits	670	Shared Neighborhood Hits	63
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZC11A_HUMAN
θ value	4.03905 (rank : 344)	NC score	0.012358 (rank : 400)
Query Neighborhood Hits	403	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	O75152, Q6AHY4, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7	Gene names	ZC3H11A, KIAA0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

BCLF1_HUMAN
θ value	5.27518 (rank : 345)	NC score	0.050987 (rank : 307)
Query Neighborhood Hits	403	Target Neighborhood Hits	298	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

BCLF1_MOUSE
θ value	5.27518 (rank : 346)	NC score	0.049941 (rank : 310)
Query Neighborhood Hits	403	Target Neighborhood Hits	303	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K019, Q8BNZ0, Q8C2E9, Q9CSW5	Gene names	Bclaf1, Btf, Kiaa0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

FIP1_HUMAN
θ value	5.27518 (rank : 347)	NC score	0.025100 (rank : 361)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

GIPC2_HUMAN
θ value	5.27518 (rank : 348)	NC score	0.200259 (rank : 199)
Query Neighborhood Hits	403	Target Neighborhood Hits	93	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

HNRL1_MOUSE
θ value	5.27518 (rank : 349)	NC score	0.032982 (rank : 343)
Query Neighborhood Hits	403	Target Neighborhood Hits	200	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

LEO1_MOUSE
θ value	5.27518 (rank : 350)	NC score	0.032763 (rank : 344)
Query Neighborhood Hits	403	Target Neighborhood Hits	946	Shared Neighborhood Hits	73
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MCF2L_MOUSE
θ value	5.27518 (rank : 351)	NC score	0.009010 (rank : 412)
Query Neighborhood Hits	403	Target Neighborhood Hits	255	Shared Neighborhood Hits	10
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MLL3_HUMAN
θ value	5.27518 (rank : 352)	NC score	0.029346 (rank : 352)
Query Neighborhood Hits	403	Target Neighborhood Hits	1644	Shared Neighborhood Hits	94
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MRP7_HUMAN
θ value	5.27518 (rank : 353)	NC score	0.002149 (rank : 433)
Query Neighborhood Hits	403	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T3U5, Q8NHX7, Q9H7N2, Q9NXY3, Q9UF48	Gene names	ABCC10, MRP7, SIMRP7
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 7 (ATP-binding cassette sub- family C member 10).

NFH_HUMAN
θ value	5.27518 (rank : 354)	NC score	0.024162 (rank : 365)
Query Neighborhood Hits	403	Target Neighborhood Hits	1242	Shared Neighborhood Hits	87
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NRG2_HUMAN
θ value	5.27518 (rank : 355)	NC score	0.001535 (rank : 436)
Query Neighborhood Hits	403	Target Neighborhood Hits	419	Shared Neighborhood Hits	13
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

PPIP2_HUMAN
θ value	5.27518 (rank : 356)	NC score	0.016814 (rank : 393)
Query Neighborhood Hits	403	Target Neighborhood Hits	254	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PRAX_MOUSE
θ value	5.27518 (rank : 357)	NC score	0.088541 (rank : 250)
Query Neighborhood Hits	403	Target Neighborhood Hits	199	Shared Neighborhood Hits	49
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

PRB3_HUMAN
θ value	5.27518 (rank : 358)	NC score	0.037049 (rank : 335)
Query Neighborhood Hits	403	Target Neighborhood Hits	318	Shared Neighborhood Hits	31
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

RBL2_HUMAN
θ value	5.27518 (rank : 359)	NC score	0.005418 (rank : 422)
Query Neighborhood Hits	403	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q08999, Q15073, Q16084, Q92812	Gene names	RBL2, RB2
Domain Architecture
Description	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).

RNF25_HUMAN
θ value	5.27518 (rank : 360)	NC score	0.020719 (rank : 379)
Query Neighborhood Hits	403	Target Neighborhood Hits	163	Shared Neighborhood Hits	16
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

SI1L1_HUMAN
θ value	5.27518 (rank : 361)	NC score	0.052127 (rank : 300)
Query Neighborhood Hits	403	Target Neighborhood Hits	162	Shared Neighborhood Hits	42
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	5.27518 (rank : 362)	NC score	0.051835 (rank : 302)
Query Neighborhood Hits	403	Target Neighborhood Hits	189	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

TCRG1_HUMAN
θ value	5.27518 (rank : 363)	NC score	0.052082 (rank : 301)
Query Neighborhood Hits	403	Target Neighborhood Hits	929	Shared Neighborhood Hits	86
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

BAG1_MOUSE
θ value	6.88961 (rank : 364)	NC score	0.011256 (rank : 406)
Query Neighborhood Hits	403	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q60739	Gene names	Bag1
Domain Architecture
Description	BAG family molecular chaperone regulator 1 (BCL-2-binding athanogene- 1) (BAG-1).

CAC1B_HUMAN
θ value	6.88961 (rank : 365)	NC score	0.008556 (rank : 414)
Query Neighborhood Hits	403	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CCNT2_HUMAN
θ value	6.88961 (rank : 366)	NC score	0.013148 (rank : 397)
Query Neighborhood Hits	403	Target Neighborhood Hits	84	Shared Neighborhood Hits	16
SwissProt Accessions	O60583, O60582, Q5I1Y0	Gene names	CCNT2
Domain Architecture
Description	Cyclin-T2 (CycT2).

CDK4_MOUSE
θ value	6.88961 (rank : 367)	NC score	0.005538 (rank : 421)
Query Neighborhood Hits	403	Target Neighborhood Hits	838	Shared Neighborhood Hits	20
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

DRP2_HUMAN
θ value	6.88961 (rank : 368)	NC score	0.046596 (rank : 316)
Query Neighborhood Hits	403	Target Neighborhood Hits	186	Shared Neighborhood Hits	28
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

EHMT2_MOUSE
θ value	6.88961 (rank : 369)	NC score	0.007730 (rank : 416)
Query Neighborhood Hits	403	Target Neighborhood Hits	750	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ETV3_HUMAN
θ value	6.88961 (rank : 370)	NC score	0.006828 (rank : 417)
Query Neighborhood Hits	403	Target Neighborhood Hits	312	Shared Neighborhood Hits	27
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

FOXGB_HUMAN
θ value	6.88961 (rank : 371)	NC score	-0.001079 (rank : 442)
Query Neighborhood Hits	403	Target Neighborhood Hits	123	Shared Neighborhood Hits	5
SwissProt Accessions	P55315	Gene names	FOXG1B, FKHL1
Domain Architecture
Description	Forkhead box protein G1B (Forkhead-related protein FKHL1) (Transcription factor BF-1) (Brain factor 1) (BF1) (HFK1).

HIRP3_HUMAN
θ value	6.88961 (rank : 372)	NC score	0.058170 (rank : 285)
Query Neighborhood Hits	403	Target Neighborhood Hits	323	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

IF3A_HUMAN
θ value	6.88961 (rank : 373)	NC score	0.026192 (rank : 358)
Query Neighborhood Hits	403	Target Neighborhood Hits	875	Shared Neighborhood Hits	57
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

LRP1B_HUMAN
θ value	6.88961 (rank : 374)	NC score	-0.004606 (rank : 446)
Query Neighborhood Hits	403	Target Neighborhood Hits	602	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LUZP1_MOUSE
θ value	6.88961 (rank : 375)	NC score	0.019886 (rank : 382)
Query Neighborhood Hits	403	Target Neighborhood Hits	940	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

PDZD6_HUMAN
θ value	6.88961 (rank : 376)	NC score	0.155901 (rank : 208)
Query Neighborhood Hits	403	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PPRB_MOUSE
θ value	6.88961 (rank : 377)	NC score	0.039480 (rank : 328)
Query Neighborhood Hits	403	Target Neighborhood Hits	354	Shared Neighborhood Hits	44
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

RFFL_HUMAN
θ value	6.88961 (rank : 378)	NC score	0.004541 (rank : 425)
Query Neighborhood Hits	403	Target Neighborhood Hits	175	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

SIM1_MOUSE
θ value	6.88961 (rank : 379)	NC score	0.001632 (rank : 435)
Query Neighborhood Hits	403	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

UBF1_HUMAN
θ value	6.88961 (rank : 380)	NC score	0.011851 (rank : 404)
Query Neighborhood Hits	403	Target Neighborhood Hits	415	Shared Neighborhood Hits	30
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

UTRO_HUMAN
θ value	6.88961 (rank : 381)	NC score	0.024401 (rank : 364)
Query Neighborhood Hits	403	Target Neighborhood Hits	960	Shared Neighborhood Hits	59
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

XRCC1_MOUSE
θ value	6.88961 (rank : 382)	NC score	0.017577 (rank : 389)
Query Neighborhood Hits	403	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

A2BP1_MOUSE
θ value	8.99809 (rank : 383)	NC score	0.006052 (rank : 420)
Query Neighborhood Hits	403	Target Neighborhood Hits	226	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JJ43, Q9JJB5	Gene names	A2bp1, A2bp
Domain Architecture
Description	Ataxin-2-binding protein 1.

AFF4_HUMAN
θ value	8.99809 (rank : 384)	NC score	0.036173 (rank : 336)
Query Neighborhood Hits	403	Target Neighborhood Hits	611	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

ATN1_HUMAN
θ value	8.99809 (rank : 385)	NC score	0.024406 (rank : 363)
Query Neighborhood Hits	403	Target Neighborhood Hits	676	Shared Neighborhood Hits	50
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

COEA1_HUMAN
θ value	8.99809 (rank : 386)	NC score	0.000288 (rank : 441)
Query Neighborhood Hits	403	Target Neighborhood Hits	427	Shared Neighborhood Hits	19
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

DNL1_HUMAN
θ value	8.99809 (rank : 387)	NC score	0.023857 (rank : 366)
Query Neighborhood Hits	403	Target Neighborhood Hits	216	Shared Neighborhood Hits	32
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

ELOA1_MOUSE
θ value	8.99809 (rank : 388)	NC score	0.023272 (rank : 367)
Query Neighborhood Hits	403	Target Neighborhood Hits	152	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CB77, Q80VB2, Q9R0Q5	Gene names	Tceb3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

EMSY_HUMAN
θ value	8.99809 (rank : 389)	NC score	0.004943 (rank : 424)
Query Neighborhood Hits	403	Target Neighborhood Hits	296	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

HTRA1_HUMAN
θ value	8.99809 (rank : 390)	NC score	0.055032 (rank : 292)
Query Neighborhood Hits	403	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

NU214_HUMAN
θ value	8.99809 (rank : 391)	NC score	0.030726 (rank : 346)
Query Neighborhood Hits	403	Target Neighborhood Hits	657	Shared Neighborhood Hits	46
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PEG3_MOUSE
θ value	8.99809 (rank : 392)	NC score	-0.004045 (rank : 444)
Query Neighborhood Hits	403	Target Neighborhood Hits	1101	Shared Neighborhood Hits	56
SwissProt Accessions	Q3URU2, O54978, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53	Gene names	Peg3, Kiaa0287, Pw1
Domain Architecture	No domain graphic available
Description	Paternally expressed gene 3 protein (ASF-1).

PGCA_MOUSE
θ value	8.99809 (rank : 393)	NC score	0.003791 (rank : 429)
Query Neighborhood Hits	403	Target Neighborhood Hits	643	Shared Neighborhood Hits	24
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

PIBF1_HUMAN
θ value	8.99809 (rank : 394)	NC score	0.012891 (rank : 398)
Query Neighborhood Hits	403	Target Neighborhood Hits	1041	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

PPRB_HUMAN
θ value	8.99809 (rank : 395)	NC score	0.035502 (rank : 339)
Query Neighborhood Hits	403	Target Neighborhood Hits	311	Shared Neighborhood Hits	39
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

PRP40_HUMAN
θ value	8.99809 (rank : 396)	NC score	0.089500 (rank : 246)
Query Neighborhood Hits	403	Target Neighborhood Hits	442	Shared Neighborhood Hits	74
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

REXO1_HUMAN
θ value	8.99809 (rank : 397)	NC score	0.026294 (rank : 357)
Query Neighborhood Hits	403	Target Neighborhood Hits	242	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

RHG12_HUMAN
θ value	8.99809 (rank : 398)	NC score	0.044842 (rank : 320)
Query Neighborhood Hits	403	Target Neighborhood Hits	190	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RNC_HUMAN
θ value	8.99809 (rank : 399)	NC score	0.020404 (rank : 381)
Query Neighborhood Hits	403	Target Neighborhood Hits	176	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

SMP1L_MOUSE
θ value	8.99809 (rank : 400)	NC score	0.001095 (rank : 438)
Query Neighborhood Hits	403	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

UBP8_MOUSE
θ value	8.99809 (rank : 401)	NC score	0.004517 (rank : 426)
Query Neighborhood Hits	403	Target Neighborhood Hits	362	Shared Neighborhood Hits	37
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

ZF106_HUMAN
θ value	8.99809 (rank : 402)	NC score	0.005075 (rank : 423)
Query Neighborhood Hits	403	Target Neighborhood Hits	470	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

ZNFX1_MOUSE
θ value	8.99809 (rank : 403)	NC score	0.004471 (rank : 428)
Query Neighborhood Hits	403	Target Neighborhood Hits	407	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

APBB2_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.054686 (rank : 293)
Query Neighborhood Hits	403	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

CAR11_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.066564 (rank : 274)
Query Neighborhood Hits	403	Target Neighborhood Hits	690	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CAR14_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.057511 (rank : 286)
Query Neighborhood Hits	403	Target Neighborhood Hits	449	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CNKR1_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.075493 (rank : 268)
Query Neighborhood Hits	403	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

DSPP_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.050369 (rank : 309)
Query Neighborhood Hits	403	Target Neighborhood Hits	491	Shared Neighborhood Hits	54
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

EDD1_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.100581 (rank : 230)
Query Neighborhood Hits	403	Target Neighborhood Hits	170	Shared Neighborhood Hits	26
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.100440 (rank : 231)
Query Neighborhood Hits	403	Target Neighborhood Hits	167	Shared Neighborhood Hits	28
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

GAS7_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.093217 (rank : 240)
Query Neighborhood Hits	403	Target Neighborhood Hits	258	Shared Neighborhood Hits	51
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.088834 (rank : 249)
Query Neighborhood Hits	403	Target Neighborhood Hits	259	Shared Neighborhood Hits	49
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

HECD1_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.089128 (rank : 248)
Query Neighborhood Hits	403	Target Neighborhood Hits	371	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD2_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.142026 (rank : 218)
Query Neighborhood Hits	403	Target Neighborhood Hits	41	Shared Neighborhood Hits	14
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.142884 (rank : 217)
Query Neighborhood Hits	403	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD3_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.098119 (rank : 235)
Query Neighborhood Hits	403	Target Neighborhood Hits	49	Shared Neighborhood Hits	14
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.099850 (rank : 234)
Query Neighborhood Hits	403	Target Neighborhood Hits	47	Shared Neighborhood Hits	14
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.092029 (rank : 243)
Query Neighborhood Hits	403	Target Neighborhood Hits	163	Shared Neighborhood Hits	20
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.093324 (rank : 239)
Query Neighborhood Hits	403	Target Neighborhood Hits	167	Shared Neighborhood Hits	22
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.114579 (rank : 226)
Query Neighborhood Hits	403	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.117740 (rank : 225)
Query Neighborhood Hits	403	Target Neighborhood Hits	66	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HTRA3_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.065150 (rank : 277)
Query Neighborhood Hits	403	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.071158 (rank : 271)
Query Neighborhood Hits	403	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HUWE1_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.150452 (rank : 212)
Query Neighborhood Hits	403	Target Neighborhood Hits	443	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.150989 (rank : 210)
Query Neighborhood Hits	403	Target Neighborhood Hits	406	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

K0317_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.149587 (rank : 213)
Query Neighborhood Hits	403	Target Neighborhood Hits	46	Shared Neighborhood Hits	15
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.149503 (rank : 214)
Query Neighborhood Hits	403	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

LMO7_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.088454 (rank : 251)
Query Neighborhood Hits	403	Target Neighborhood Hits	507	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MDC1_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.051365 (rank : 304)
Query Neighborhood Hits	403	Target Neighborhood Hits	1446	Shared Neighborhood Hits	115
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NOLC1_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.050613 (rank : 308)
Query Neighborhood Hits	403	Target Neighborhood Hits	452	Shared Neighborhood Hits	51
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PCLO_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.057442 (rank : 288)
Query Neighborhood Hits	403	Target Neighborhood Hits	2046	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PDZD8_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.092766 (rank : 242)
Query Neighborhood Hits	403	Target Neighborhood Hits	185	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PRAX_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.062659 (rank : 280)
Query Neighborhood Hits	403	Target Neighborhood Hits	215	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRP40_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.089299 (rank : 247)
Query Neighborhood Hits	403	Target Neighborhood Hits	447	Shared Neighborhood Hits	76
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

PSMD9_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.054069 (rank : 295)
Query Neighborhood Hits	403	Target Neighborhood Hits	36	Shared Neighborhood Hits	20
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

RAIN_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.053940 (rank : 297)
Query Neighborhood Hits	403	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q5U651, Q6U676	Gene names	RASIP1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

RAIN_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.053083 (rank : 299)
Query Neighborhood Hits	403	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

RHPN2_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.075096 (rank : 269)
Query Neighborhood Hits	403	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

RNF41_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.062924 (rank : 279)
Query Neighborhood Hits	403	Target Neighborhood Hits	226	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.063151 (rank : 278)
Query Neighborhood Hits	403	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

SFR12_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.051494 (rank : 303)
Query Neighborhood Hits	403	Target Neighborhood Hits	553	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

SFR17_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.055293 (rank : 291)
Query Neighborhood Hits	403	Target Neighborhood Hits	325	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TF01, Q5T064, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8TF00, Q96K10, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3	Gene names	SRRP130, C6orf111
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 130 (Serine-arginine-rich- splicing regulatory protein 130) (SRrp130) (SR-rich protein) (SR- related protein).

UBE3A_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.138831 (rank : 220)
Query Neighborhood Hits	403	Target Neighborhood Hits	49	Shared Neighborhood Hits	15
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.137051 (rank : 222)
Query Neighborhood Hits	403	Target Neighborhood Hits	47	Shared Neighborhood Hits	16
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.137054 (rank : 221)
Query Neighborhood Hits	403	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.136778 (rank : 223)
Query Neighborhood Hits	403	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

VCY1_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.061193 (rank : 281)
Query Neighborhood Hits	403	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	O14598	Gene names	VCY, BPY1
Domain Architecture	No domain graphic available
Description	Testis-specific basic protein Y 1 (Variably charged protein Y).

ZC313_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.058714 (rank : 283)
Query Neighborhood Hits	403	Target Neighborhood Hits	772	Shared Neighborhood Hits	77
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

Hits sorted by NC score

MAGI1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	403	Target Neighborhood Hits	403	Shared Neighborhood Hits	403
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
NC score	0.985864 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	403	Target Neighborhood Hits	388	Shared Neighborhood Hits	312
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI2_MOUSE
NC score	0.956035 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	403	Target Neighborhood Hits	370	Shared Neighborhood Hits	241
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.955359 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	403	Target Neighborhood Hits	373	Shared Neighborhood Hits	239
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MPDZ_HUMAN
NC score	0.730034 (rank : 5)	θ value	5.59698e-26 (rank : 5)
Query Neighborhood Hits	403	Target Neighborhood Hits	261	Shared Neighborhood Hits	202
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

INADL_MOUSE
NC score	0.725740 (rank : 6)	θ value	5.79196e-23 (rank : 6)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	202
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MPDZ_MOUSE
NC score	0.723935 (rank : 7)	θ value	1.42661e-21 (rank : 7)
Query Neighborhood Hits	403	Target Neighborhood Hits	298	Shared Neighborhood Hits	202
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

INADL_HUMAN
NC score	0.720126 (rank : 8)	θ value	2.43343e-21 (rank : 8)
Query Neighborhood Hits	403	Target Neighborhood Hits	260	Shared Neighborhood Hits	195
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

LIN7B_HUMAN
NC score	0.714503 (rank : 9)	θ value	4.59992e-12 (rank : 44)
Query Neighborhood Hits	403	Target Neighborhood Hits	200	Shared Neighborhood Hits	190
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
NC score	0.713394 (rank : 10)	θ value	6.00763e-12 (rank : 45)
Query Neighborhood Hits	403	Target Neighborhood Hits	200	Shared Neighborhood Hits	190
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
NC score	0.713159 (rank : 11)	θ value	2.69671e-12 (rank : 41)
Query Neighborhood Hits	403	Target Neighborhood Hits	198	Shared Neighborhood Hits	190
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.713159 (rank : 12)	θ value	2.69671e-12 (rank : 42)
Query Neighborhood Hits	403	Target Neighborhood Hits	198	Shared Neighborhood Hits	190
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

SYJ2B_HUMAN
NC score	0.712125 (rank : 13)	θ value	2.79066e-09 (rank : 66)
Query Neighborhood Hits	403	Target Neighborhood Hits	162	Shared Neighborhood Hits	159
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

LIN7A_MOUSE
NC score	0.708852 (rank : 14)	θ value	1.133e-10 (rank : 55)
Query Neighborhood Hits	403	Target Neighborhood Hits	193	Shared Neighborhood Hits	189
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.708687 (rank : 15)	θ value	1.133e-10 (rank : 54)
Query Neighborhood Hits	403	Target Neighborhood Hits	193	Shared Neighborhood Hits	189
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

PDZD7_HUMAN
NC score	0.699242 (rank : 16)	θ value	8.11959e-09 (rank : 75)
Query Neighborhood Hits	403	Target Neighborhood Hits	181	Shared Neighborhood Hits	172
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

GRIP2_HUMAN
NC score	0.681224 (rank : 17)	θ value	8.10077e-17 (rank : 13)
Query Neighborhood Hits	403	Target Neighborhood Hits	256	Shared Neighborhood Hits	200
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GRIP1_HUMAN
NC score	0.674045 (rank : 18)	θ value	1.38178e-16 (rank : 15)
Query Neighborhood Hits	403	Target Neighborhood Hits	231	Shared Neighborhood Hits	197
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

PARD3_MOUSE
NC score	0.672367 (rank : 19)	θ value	1.63225e-17 (rank : 12)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	186
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDZD1_MOUSE
NC score	0.671252 (rank : 20)	θ value	1.16975e-15 (rank : 19)
Query Neighborhood Hits	403	Target Neighborhood Hits	191	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

USH1C_HUMAN
NC score	0.670139 (rank : 21)	θ value	2.79066e-09 (rank : 67)
Query Neighborhood Hits	403	Target Neighborhood Hits	327	Shared Neighborhood Hits	195
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PARD3_HUMAN
NC score	0.669693 (rank : 22)	θ value	5.25075e-16 (rank : 18)
Query Neighborhood Hits	403	Target Neighborhood Hits	312	Shared Neighborhood Hits	189
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

GRIP1_MOUSE
NC score	0.666897 (rank : 23)	θ value	1.58096e-12 (rank : 37)
Query Neighborhood Hits	403	Target Neighborhood Hits	241	Shared Neighborhood Hits	198
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

WHRN_HUMAN
NC score	0.660291 (rank : 24)	θ value	1.74796e-11 (rank : 50)
Query Neighborhood Hits	403	Target Neighborhood Hits	325	Shared Neighborhood Hits	203
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.658774 (rank : 25)	θ value	5.43371e-13 (rank : 34)
Query Neighborhood Hits	403	Target Neighborhood Hits	412	Shared Neighborhood Hits	205
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PDZD1_HUMAN
NC score	0.658541 (rank : 26)	θ value	7.58209e-15 (rank : 23)
Query Neighborhood Hits	403	Target Neighborhood Hits	190	Shared Neighborhood Hits	163
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

DLG4_MOUSE
NC score	0.653700 (rank : 27)	θ value	2.5182e-18 (rank : 10)
Query Neighborhood Hits	403	Target Neighborhood Hits	282	Shared Neighborhood Hits	187
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

PAR3L_HUMAN
NC score	0.653529 (rank : 28)	θ value	3.89403e-11 (rank : 51)
Query Neighborhood Hits	403	Target Neighborhood Hits	297	Shared Neighborhood Hits	164
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

DLG4_HUMAN
NC score	0.652889 (rank : 29)	θ value	1.92812e-18 (rank : 9)
Query Neighborhood Hits	403	Target Neighborhood Hits	286	Shared Neighborhood Hits	185
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

NHRF2_HUMAN
NC score	0.648297 (rank : 30)	θ value	1.42992e-13 (rank : 26)
Query Neighborhood Hits	403	Target Neighborhood Hits	197	Shared Neighborhood Hits	175
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

DLG3_MOUSE
NC score	0.646729 (rank : 31)	θ value	1.52774e-15 (rank : 20)
Query Neighborhood Hits	403	Target Neighborhood Hits	274	Shared Neighborhood Hits	183
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

NHERF_MOUSE
NC score	0.645859 (rank : 32)	θ value	1.02475e-11 (rank : 47)
Query Neighborhood Hits	403	Target Neighborhood Hits	195	Shared Neighborhood Hits	168
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

DLG3_HUMAN
NC score	0.644415 (rank : 33)	θ value	4.44505e-15 (rank : 21)
Query Neighborhood Hits	403	Target Neighborhood Hits	269	Shared Neighborhood Hits	183
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

NHRF2_MOUSE
NC score	0.639765 (rank : 34)	θ value	7.84624e-12 (rank : 46)
Query Neighborhood Hits	403	Target Neighborhood Hits	194	Shared Neighborhood Hits	175
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

DLG2_HUMAN
NC score	0.636851 (rank : 35)	θ value	3.18553e-13 (rank : 29)
Query Neighborhood Hits	403	Target Neighborhood Hits	279	Shared Neighborhood Hits	184
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG1_HUMAN
NC score	0.636638 (rank : 36)	θ value	3.18553e-13 (rank : 28)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	182
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
NC score	0.635719 (rank : 37)	θ value	1.86753e-13 (rank : 27)
Query Neighborhood Hits	403	Target Neighborhood Hits	285	Shared Neighborhood Hits	178
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG2_MOUSE
NC score	0.633676 (rank : 38)	θ value	4.16044e-13 (rank : 32)
Query Neighborhood Hits	403	Target Neighborhood Hits	271	Shared Neighborhood Hits	182
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

NHERF_HUMAN
NC score	0.628391 (rank : 39)	θ value	5.62301e-10 (rank : 61)
Query Neighborhood Hits	403	Target Neighborhood Hits	190	Shared Neighborhood Hits	165
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZ11_HUMAN
NC score	0.628108 (rank : 40)	θ value	1.43324e-05 (rank : 112)
Query Neighborhood Hits	403	Target Neighborhood Hits	160	Shared Neighborhood Hits	151
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
NC score	0.625833 (rank : 41)	θ value	1.43324e-05 (rank : 113)
Query Neighborhood Hits	403	Target Neighborhood Hits	154	Shared Neighborhood Hits	144
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

USH1C_MOUSE
NC score	0.625317 (rank : 42)	θ value	2.36244e-08 (rank : 77)
Query Neighborhood Hits	403	Target Neighborhood Hits	557	Shared Neighborhood Hits	209
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

LNX2_MOUSE
NC score	0.623580 (rank : 43)	θ value	1.09485e-13 (rank : 25)
Query Neighborhood Hits	403	Target Neighborhood Hits	407	Shared Neighborhood Hits	184
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LNX2_HUMAN
NC score	0.622319 (rank : 44)	θ value	3.18553e-13 (rank : 31)
Query Neighborhood Hits	403	Target Neighborhood Hits	389	Shared Neighborhood Hits	183
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

PDZD2_HUMAN
NC score	0.618998 (rank : 45)	θ value	3.64472e-09 (rank : 68)
Query Neighborhood Hits	403	Target Neighborhood Hits	772	Shared Neighborhood Hits	222
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

LNX1_MOUSE
NC score	0.617893 (rank : 46)	θ value	4.16044e-13 (rank : 33)
Query Neighborhood Hits	403	Target Neighborhood Hits	377	Shared Neighborhood Hits	182
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

IL16_HUMAN
NC score	0.615600 (rank : 47)	θ value	1.63604e-09 (rank : 65)
Query Neighborhood Hits	403	Target Neighborhood Hits	207	Shared Neighborhood Hits	148
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LNX1_HUMAN
NC score	0.615387 (rank : 48)	θ value	3.18553e-13 (rank : 30)
Query Neighborhood Hits	403	Target Neighborhood Hits	379	Shared Neighborhood Hits	174
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

GOPC_MOUSE
NC score	0.612127 (rank : 49)	θ value	2.61198e-07 (rank : 82)
Query Neighborhood Hits	403	Target Neighborhood Hits	323	Shared Neighborhood Hits	177
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

GOPC_HUMAN
NC score	0.602613 (rank : 50)	θ value	2.61198e-07 (rank : 81)
Query Neighborhood Hits	403	Target Neighborhood Hits	377	Shared Neighborhood Hits	179
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

SNTG2_HUMAN
NC score	0.597688 (rank : 51)	θ value	3.08544e-08 (rank : 78)
Query Neighborhood Hits	403	Target Neighborhood Hits	191	Shared Neighborhood Hits	183
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

PDZD3_HUMAN
NC score	0.596389 (rank : 52)	θ value	1.69304e-06 (rank : 90)
Query Neighborhood Hits	403	Target Neighborhood Hits	180	Shared Neighborhood Hits	168
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

IL16_MOUSE
NC score	0.584258 (rank : 53)	θ value	8.97725e-08 (rank : 79)
Query Neighborhood Hits	403	Target Neighborhood Hits	189	Shared Neighborhood Hits	146
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

ZO3_MOUSE
NC score	0.581689 (rank : 54)	θ value	1.58096e-12 (rank : 38)
Query Neighborhood Hits	403	Target Neighborhood Hits	224	Shared Neighborhood Hits	183
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

TX1B3_HUMAN
NC score	0.575997 (rank : 55)	θ value	0.00228821 (rank : 180)
Query Neighborhood Hits	403	Target Neighborhood Hits	161	Shared Neighborhood Hits	153
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

ZO3_HUMAN
NC score	0.575354 (rank : 56)	θ value	2.0648e-12 (rank : 40)
Query Neighborhood Hits	403	Target Neighborhood Hits	219	Shared Neighborhood Hits	177
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SNTG1_HUMAN
NC score	0.575287 (rank : 57)	θ value	3.64472e-09 (rank : 70)
Query Neighborhood Hits	403	Target Neighborhood Hits	181	Shared Neighborhood Hits	175
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
NC score	0.574307 (rank : 58)	θ value	4.76016e-09 (rank : 72)
Query Neighborhood Hits	403	Target Neighborhood Hits	179	Shared Neighborhood Hits	174
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

TX1B3_MOUSE
NC score	0.572672 (rank : 59)	θ value	0.00228821 (rank : 181)
Query Neighborhood Hits	403	Target Neighborhood Hits	158	Shared Neighborhood Hits	150
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

PDZD3_MOUSE
NC score	0.572555 (rank : 60)	θ value	8.40245e-06 (rank : 106)
Query Neighborhood Hits	403	Target Neighborhood Hits	171	Shared Neighborhood Hits	164
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

SNTG2_MOUSE
NC score	0.564675 (rank : 61)	θ value	2.88788e-06 (rank : 96)
Query Neighborhood Hits	403	Target Neighborhood Hits	176	Shared Neighborhood Hits	171
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTB2_HUMAN
NC score	0.561483 (rank : 62)	θ value	9.92553e-07 (rank : 87)
Query Neighborhood Hits	403	Target Neighborhood Hits	180	Shared Neighborhood Hits	163
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
NC score	0.561059 (rank : 63)	θ value	1.29631e-06 (rank : 89)
Query Neighborhood Hits	403	Target Neighborhood Hits	181	Shared Neighborhood Hits	163
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTA1_HUMAN
NC score	0.559688 (rank : 64)	θ value	8.97725e-08 (rank : 80)
Query Neighborhood Hits	403	Target Neighborhood Hits	186	Shared Neighborhood Hits	169
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
NC score	0.550215 (rank : 65)	θ value	2.21117e-06 (rank : 92)
Query Neighborhood Hits	403	Target Neighborhood Hits	170	Shared Neighborhood Hits	163
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

K1849_HUMAN
NC score	0.528040 (rank : 66)	θ value	6.64225e-11 (rank : 52)
Query Neighborhood Hits	403	Target Neighborhood Hits	220	Shared Neighborhood Hits	145
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

ZO1_MOUSE
NC score	0.525584 (rank : 67)	θ value	2.52405e-10 (rank : 59)
Query Neighborhood Hits	403	Target Neighborhood Hits	453	Shared Neighborhood Hits	200
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTB1_HUMAN
NC score	0.524173 (rank : 68)	θ value	5.44631e-05 (rank : 133)
Query Neighborhood Hits	403	Target Neighborhood Hits	157	Shared Neighborhood Hits	152
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.520812 (rank : 69)	θ value	5.44631e-05 (rank : 134)
Query Neighborhood Hits	403	Target Neighborhood Hits	160	Shared Neighborhood Hits	150
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

ZO1_HUMAN
NC score	0.520105 (rank : 70)	θ value	3.64472e-09 (rank : 71)
Query Neighborhood Hits	403	Target Neighborhood Hits	474	Shared Neighborhood Hits	196
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

PZRN4_HUMAN
NC score	0.517826 (rank : 71)	θ value	9.59137e-10 (rank : 64)
Query Neighborhood Hits	403	Target Neighborhood Hits	438	Shared Neighborhood Hits	159
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

K1849_MOUSE
NC score	0.507650 (rank : 72)	θ value	8.67504e-11 (rank : 53)
Query Neighborhood Hits	403	Target Neighborhood Hits	335	Shared Neighborhood Hits	153
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

ZO2_HUMAN
NC score	0.497712 (rank : 73)	θ value	0.00102713 (rank : 172)
Query Neighborhood Hits	403	Target Neighborhood Hits	289	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

PZRN3_MOUSE
NC score	0.492420 (rank : 74)	θ value	2.61198e-07 (rank : 83)
Query Neighborhood Hits	403	Target Neighborhood Hits	447	Shared Neighborhood Hits	161
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

ZO2_MOUSE
NC score	0.492310 (rank : 75)	θ value	0.00390308 (rank : 189)
Query Neighborhood Hits	403	Target Neighborhood Hits	296	Shared Neighborhood Hits	189
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

PZRN3_HUMAN
NC score	0.489362 (rank : 76)	θ value	1.29631e-06 (rank : 88)
Query Neighborhood Hits	403	Target Neighborhood Hits	461	Shared Neighborhood Hits	162
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PDLI2_HUMAN
NC score	0.462699 (rank : 77)	θ value	8.40245e-06 (rank : 105)
Query Neighborhood Hits	403	Target Neighborhood Hits	245	Shared Neighborhood Hits	129
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

GRASP_MOUSE
NC score	0.455015 (rank : 78)	θ value	3.77169e-06 (rank : 98)
Query Neighborhood Hits	403	Target Neighborhood Hits	131	Shared Neighborhood Hits	118
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_HUMAN
NC score	0.453675 (rank : 79)	θ value	3.19293e-05 (rank : 123)
Query Neighborhood Hits	403	Target Neighborhood Hits	147	Shared Neighborhood Hits	119
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

LAP4_HUMAN
NC score	0.450594 (rank : 80)	θ value	7.58209e-15 (rank : 22)
Query Neighborhood Hits	403	Target Neighborhood Hits	608	Shared Neighborhood Hits	213
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

MPP4_HUMAN
NC score	0.449465 (rank : 81)	θ value	0.00020696 (rank : 147)
Query Neighborhood Hits	403	Target Neighborhood Hits	205	Shared Neighborhood Hits	142
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

PDLI2_MOUSE
NC score	0.445358 (rank : 82)	θ value	2.21117e-06 (rank : 91)
Query Neighborhood Hits	403	Target Neighborhood Hits	220	Shared Neighborhood Hits	124
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

LAP4_MOUSE
NC score	0.442372 (rank : 83)	θ value	1.68911e-14 (rank : 24)
Query Neighborhood Hits	403	Target Neighborhood Hits	590	Shared Neighborhood Hits	206
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PSCBP_MOUSE
NC score	0.438738 (rank : 84)	θ value	2.44474e-05 (rank : 122)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	113
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SAV1_HUMAN
NC score	0.437349 (rank : 85)	θ value	1.2105e-12 (rank : 36)
Query Neighborhood Hits	403	Target Neighborhood Hits	51	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.436515 (rank : 86)	θ value	2.69671e-12 (rank : 43)
Query Neighborhood Hits	403	Target Neighborhood Hits	48	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

APBA3_HUMAN
NC score	0.436246 (rank : 87)	θ value	4.92598e-06 (rank : 99)
Query Neighborhood Hits	403	Target Neighborhood Hits	201	Shared Neighborhood Hits	148
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA1_HUMAN
NC score	0.431783 (rank : 88)	θ value	1.87187e-05 (rank : 114)
Query Neighborhood Hits	403	Target Neighborhood Hits	325	Shared Neighborhood Hits	167
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

MPP3_MOUSE
NC score	0.431689 (rank : 89)	θ value	1.87187e-05 (rank : 117)
Query Neighborhood Hits	403	Target Neighborhood Hits	165	Shared Neighborhood Hits	134
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

STXB4_HUMAN
NC score	0.430304 (rank : 90)	θ value	2.88788e-06 (rank : 97)
Query Neighborhood Hits	403	Target Neighborhood Hits	616	Shared Neighborhood Hits	146
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MPP5_HUMAN
NC score	0.428779 (rank : 91)	θ value	0.000121331 (rank : 140)
Query Neighborhood Hits	403	Target Neighborhood Hits	231	Shared Neighborhood Hits	141
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

AFAD_HUMAN
NC score	0.427624 (rank : 92)	θ value	8.40245e-06 (rank : 104)
Query Neighborhood Hits	403	Target Neighborhood Hits	689	Shared Neighborhood Hits	162
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

MPP3_HUMAN
NC score	0.427580 (rank : 93)	θ value	1.87187e-05 (rank : 116)
Query Neighborhood Hits	403	Target Neighborhood Hits	171	Shared Neighborhood Hits	135
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP5_MOUSE
NC score	0.427000 (rank : 94)	θ value	0.000270298 (rank : 154)
Query Neighborhood Hits	403	Target Neighborhood Hits	226	Shared Neighborhood Hits	141
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

STXB4_MOUSE
NC score	0.424829 (rank : 95)	θ value	1.09739e-05 (rank : 108)
Query Neighborhood Hits	403	Target Neighborhood Hits	629	Shared Neighborhood Hits	143
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PSCBP_HUMAN
NC score	0.424401 (rank : 96)	θ value	4.1701e-05 (rank : 129)
Query Neighborhood Hits	403	Target Neighborhood Hits	123	Shared Neighborhood Hits	115
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PTN13_HUMAN
NC score	0.421729 (rank : 97)	θ value	7.32683e-18 (rank : 11)
Query Neighborhood Hits	403	Target Neighborhood Hits	471	Shared Neighborhood Hits	213
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

APBA3_MOUSE
NC score	0.421683 (rank : 98)	θ value	6.43352e-06 (rank : 100)
Query Neighborhood Hits	403	Target Neighborhood Hits	174	Shared Neighborhood Hits	137
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

MPP4_MOUSE
NC score	0.413897 (rank : 99)	θ value	0.000270298 (rank : 153)
Query Neighborhood Hits	403	Target Neighborhood Hits	188	Shared Neighborhood Hits	123
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

APBA2_MOUSE
NC score	0.413822 (rank : 100)	θ value	0.000270298 (rank : 149)
Query Neighborhood Hits	403	Target Neighborhood Hits	219	Shared Neighborhood Hits	156
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.413515 (rank : 101)	θ value	0.000270298 (rank : 148)
Query Neighborhood Hits	403	Target Neighborhood Hits	220	Shared Neighborhood Hits	155
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

PTN13_MOUSE
NC score	0.410271 (rank : 102)	θ value	1.058e-16 (rank : 14)
Query Neighborhood Hits	403	Target Neighborhood Hits	426	Shared Neighborhood Hits	200
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

YAP1_MOUSE
NC score	0.401988 (rank : 103)	θ value	2.0648e-12 (rank : 39)
Query Neighborhood Hits	403	Target Neighborhood Hits	96	Shared Neighborhood Hits	52
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SYP2L_HUMAN
NC score	0.401156 (rank : 104)	θ value	3.19293e-05 (rank : 124)
Query Neighborhood Hits	403	Target Neighborhood Hits	400	Shared Neighborhood Hits	125
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

EM55_HUMAN
NC score	0.400018 (rank : 105)	θ value	7.59969e-07 (rank : 86)
Query Neighborhood Hits	403	Target Neighborhood Hits	228	Shared Neighborhood Hits	132
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

PICK1_MOUSE
NC score	0.396948 (rank : 106)	θ value	0.00869519 (rank : 195)
Query Neighborhood Hits	403	Target Neighborhood Hits	131	Shared Neighborhood Hits	122
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_HUMAN
NC score	0.396069 (rank : 107)	θ value	0.00869519 (rank : 194)
Query Neighborhood Hits	403	Target Neighborhood Hits	132	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

EM55_MOUSE
NC score	0.393295 (rank : 108)	θ value	4.1701e-05 (rank : 127)
Query Neighborhood Hits	403	Target Neighborhood Hits	221	Shared Neighborhood Hits	130
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

NEB1_HUMAN
NC score	0.390963 (rank : 109)	θ value	0.000121331 (rank : 141)
Query Neighborhood Hits	403	Target Neighborhood Hits	829	Shared Neighborhood Hits	159
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

WWC1_HUMAN
NC score	0.388733 (rank : 110)	θ value	4.02038e-16 (rank : 16)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.386875 (rank : 111)	θ value	4.02038e-16 (rank : 17)
Query Neighborhood Hits	403	Target Neighborhood Hits	290	Shared Neighborhood Hits	51
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

DLG5_HUMAN
NC score	0.386058 (rank : 112)	θ value	1.87187e-05 (rank : 115)
Query Neighborhood Hits	403	Target Neighborhood Hits	1088	Shared Neighborhood Hits	202
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

NEB2_HUMAN
NC score	0.371942 (rank : 113)	θ value	2.44474e-05 (rank : 120)
Query Neighborhood Hits	403	Target Neighborhood Hits	883	Shared Neighborhood Hits	146
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
NC score	0.368946 (rank : 114)	θ value	2.44474e-05 (rank : 121)
Query Neighborhood Hits	403	Target Neighborhood Hits	889	Shared Neighborhood Hits	149
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PDZK4_HUMAN
NC score	0.368278 (rank : 115)	θ value	0.0148317 (rank : 199)
Query Neighborhood Hits	403	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
NC score	0.366587 (rank : 116)	θ value	0.0563607 (rank : 213)
Query Neighborhood Hits	403	Target Neighborhood Hits	165	Shared Neighborhood Hits	131
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

RHPN1_MOUSE
NC score	0.363339 (rank : 117)	θ value	0.00134147 (rank : 173)
Query Neighborhood Hits	403	Target Neighborhood Hits	154	Shared Neighborhood Hits	131
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SYNP2_MOUSE
NC score	0.360644 (rank : 118)	θ value	0.000602161 (rank : 165)
Query Neighborhood Hits	403	Target Neighborhood Hits	252	Shared Neighborhood Hits	124
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

DVL3_MOUSE
NC score	0.357834 (rank : 119)	θ value	0.0193708 (rank : 202)
Query Neighborhood Hits	403	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
NC score	0.356941 (rank : 120)	θ value	0.0193708 (rank : 201)
Query Neighborhood Hits	403	Target Neighborhood Hits	194	Shared Neighborhood Hits	121
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1_HUMAN
NC score	0.356190 (rank : 121)	θ value	0.00509761 (rank : 190)
Query Neighborhood Hits	403	Target Neighborhood Hits	158	Shared Neighborhood Hits	121
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

MPP6_MOUSE
NC score	0.353827 (rank : 122)	θ value	0.00035302 (rank : 158)
Query Neighborhood Hits	403	Target Neighborhood Hits	187	Shared Neighborhood Hits	100
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

DVL1_MOUSE
NC score	0.352213 (rank : 123)	θ value	0.00665767 (rank : 192)
Query Neighborhood Hits	403	Target Neighborhood Hits	146	Shared Neighborhood Hits	117
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

RPGF6_HUMAN
NC score	0.351231 (rank : 124)	θ value	0.00298849 (rank : 185)
Query Neighborhood Hits	403	Target Neighborhood Hits	266	Shared Neighborhood Hits	161
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PAR6G_MOUSE
NC score	0.350308 (rank : 125)	θ value	0.125558 (rank : 218)
Query Neighborhood Hits	403	Target Neighborhood Hits	121	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

MPP2_MOUSE
NC score	0.349666 (rank : 126)	θ value	0.000158464 (rank : 146)
Query Neighborhood Hits	403	Target Neighborhood Hits	189	Shared Neighborhood Hits	103
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP6_HUMAN
NC score	0.349202 (rank : 127)	θ value	0.00035302 (rank : 157)
Query Neighborhood Hits	403	Target Neighborhood Hits	180	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP2_HUMAN
NC score	0.346132 (rank : 128)	θ value	0.000270298 (rank : 152)
Query Neighborhood Hits	403	Target Neighborhood Hits	173	Shared Neighborhood Hits	96
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

PAR6B_HUMAN
NC score	0.343436 (rank : 129)	θ value	0.163984 (rank : 222)
Query Neighborhood Hits	403	Target Neighborhood Hits	126	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
NC score	0.343287 (rank : 130)	θ value	0.163984 (rank : 223)
Query Neighborhood Hits	403	Target Neighborhood Hits	128	Shared Neighborhood Hits	121
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

DVL1L_HUMAN
NC score	0.342752 (rank : 131)	θ value	0.0193708 (rank : 200)
Query Neighborhood Hits	403	Target Neighborhood Hits	146	Shared Neighborhood Hits	116
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

PAR6G_HUMAN
NC score	0.342633 (rank : 132)	θ value	0.47712 (rank : 243)
Query Neighborhood Hits	403	Target Neighborhood Hits	159	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

SHAN2_HUMAN
NC score	0.340369 (rank : 133)	θ value	0.000786445 (rank : 169)
Query Neighborhood Hits	403	Target Neighborhood Hits	346	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

APXL_HUMAN
NC score	0.339531 (rank : 134)	θ value	0.000270298 (rank : 150)
Query Neighborhood Hits	403	Target Neighborhood Hits	553	Shared Neighborhood Hits	128
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARHGB_HUMAN
NC score	0.338315 (rank : 135)	θ value	1.09739e-05 (rank : 107)
Query Neighborhood Hits	403	Target Neighborhood Hits	375	Shared Neighborhood Hits	173
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DVL2_HUMAN
NC score	0.335322 (rank : 136)	θ value	0.0736092 (rank : 214)
Query Neighborhood Hits	403	Target Neighborhood Hits	223	Shared Neighborhood Hits	122
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
NC score	0.333905 (rank : 137)	θ value	0.0736092 (rank : 215)
Query Neighborhood Hits	403	Target Neighborhood Hits	233	Shared Neighborhood Hits	119
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

SYP2L_MOUSE
NC score	0.332320 (rank : 138)	θ value	5.44631e-05 (rank : 135)
Query Neighborhood Hits	403	Target Neighborhood Hits	289	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PAR6A_MOUSE
NC score	0.332210 (rank : 139)	θ value	0.47712 (rank : 242)
Query Neighborhood Hits	403	Target Neighborhood Hits	115	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6A_HUMAN
NC score	0.329859 (rank : 140)	θ value	0.125558 (rank : 217)
Query Neighborhood Hits	403	Target Neighborhood Hits	119	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

SDCB1_MOUSE
NC score	0.328185 (rank : 141)	θ value	1.81305 (rank : 295)
Query Neighborhood Hits	403	Target Neighborhood Hits	144	Shared Neighborhood Hits	134
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

PDLI3_HUMAN
NC score	0.324758 (rank : 142)	θ value	0.00298849 (rank : 183)
Query Neighborhood Hits	403	Target Neighborhood Hits	199	Shared Neighborhood Hits	108
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

RHPN1_HUMAN
NC score	0.320239 (rank : 143)	θ value	0.125558 (rank : 219)
Query Neighborhood Hits	403	Target Neighborhood Hits	158	Shared Neighborhood Hits	126
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SDCB1_HUMAN
NC score	0.319176 (rank : 144)	θ value	1.81305 (rank : 294)
Query Neighborhood Hits	403	Target Neighborhood Hits	150	Shared Neighborhood Hits	142
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SYNP2_HUMAN
NC score	0.317546 (rank : 145)	θ value	0.00035302 (rank : 160)
Query Neighborhood Hits	403	Target Neighborhood Hits	323	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

PDLI4_HUMAN
NC score	0.316513 (rank : 146)	θ value	0.00665767 (rank : 193)
Query Neighborhood Hits	403	Target Neighborhood Hits	245	Shared Neighborhood Hits	111
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI1_MOUSE
NC score	0.315460 (rank : 147)	θ value	0.0193708 (rank : 205)
Query Neighborhood Hits	403	Target Neighborhood Hits	213	Shared Neighborhood Hits	102
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI4_MOUSE
NC score	0.313050 (rank : 148)	θ value	0.0330416 (rank : 208)
Query Neighborhood Hits	403	Target Neighborhood Hits	233	Shared Neighborhood Hits	114
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

WWP2_HUMAN
NC score	0.311034 (rank : 149)	θ value	7.09661e-13 (rank : 35)
Query Neighborhood Hits	403	Target Neighborhood Hits	177	Shared Neighborhood Hits	68
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

PDLI1_HUMAN
NC score	0.310756 (rank : 150)	θ value	0.00390308 (rank : 187)
Query Neighborhood Hits	403	Target Neighborhood Hits	242	Shared Neighborhood Hits	101
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

YAP1_HUMAN
NC score	0.309695 (rank : 151)	θ value	6.43352e-06 (rank : 103)
Query Neighborhood Hits	403	Target Neighborhood Hits	173	Shared Neighborhood Hits	54
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

WWP2_MOUSE
NC score	0.308926 (rank : 152)	θ value	1.02475e-11 (rank : 48)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

SHAN2_MOUSE
NC score	0.306251 (rank : 153)	θ value	0.00134147 (rank : 174)
Query Neighborhood Hits	403	Target Neighborhood Hits	446	Shared Neighborhood Hits	132
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ARHGC_HUMAN
NC score	0.305993 (rank : 154)	θ value	0.00035302 (rank : 156)
Query Neighborhood Hits	403	Target Neighborhood Hits	351	Shared Neighborhood Hits	155
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RGS12_HUMAN
NC score	0.305228 (rank : 155)	θ value	2.88788e-06 (rank : 95)
Query Neighborhood Hits	403	Target Neighborhood Hits	333	Shared Neighborhood Hits	141
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

WWP1_MOUSE
NC score	0.303524 (rank : 156)	θ value	1.47974e-10 (rank : 57)
Query Neighborhood Hits	403	Target Neighborhood Hits	138	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ARHGC_MOUSE
NC score	0.302280 (rank : 157)	θ value	0.000270298 (rank : 151)
Query Neighborhood Hits	403	Target Neighborhood Hits	344	Shared Neighborhood Hits	157
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PDLI3_MOUSE
NC score	0.302044 (rank : 158)	θ value	0.0252991 (rank : 207)
Query Neighborhood Hits	403	Target Neighborhood Hits	197	Shared Neighborhood Hits	104
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

RPGF2_HUMAN
NC score	0.301071 (rank : 159)	θ value	0.00298849 (rank : 184)
Query Neighborhood Hits	403	Target Neighborhood Hits	242	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

WWP1_HUMAN
NC score	0.300761 (rank : 160)	θ value	1.133e-10 (rank : 56)
Query Neighborhood Hits	403	Target Neighborhood Hits	262	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ITCH_MOUSE
NC score	0.300213 (rank : 161)	θ value	2.52405e-10 (rank : 58)
Query Neighborhood Hits	403	Target Neighborhood Hits	127	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
NC score	0.297885 (rank : 162)	θ value	3.29651e-10 (rank : 60)
Query Neighborhood Hits	403	Target Neighborhood Hits	162	Shared Neighborhood Hits	53
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWTR1_MOUSE
NC score	0.296441 (rank : 163)	θ value	9.29e-05 (rank : 139)
Query Neighborhood Hits	403	Target Neighborhood Hits	54	Shared Neighborhood Hits	37
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

KGUA_HUMAN
NC score	0.295297 (rank : 164)	θ value	0.00228821 (rank : 179)
Query Neighborhood Hits	403	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

WWTR1_HUMAN
NC score	0.293597 (rank : 165)	θ value	0.000121331 (rank : 143)
Query Neighborhood Hits	403	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

KGUA_MOUSE
NC score	0.292185 (rank : 166)	θ value	0.00298849 (rank : 182)
Query Neighborhood Hits	403	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

SDCB2_MOUSE
NC score	0.290232 (rank : 167)	θ value	4.03905 (rank : 341)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	111
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

NOS1_HUMAN
NC score	0.287820 (rank : 168)	θ value	0.000786445 (rank : 167)
Query Neighborhood Hits	403	Target Neighborhood Hits	218	Shared Neighborhood Hits	138
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SMUF2_HUMAN
NC score	0.285129 (rank : 169)	θ value	3.64472e-09 (rank : 69)
Query Neighborhood Hits	403	Target Neighborhood Hits	142	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
NC score	0.282924 (rank : 170)	θ value	1.06045e-08 (rank : 76)
Query Neighborhood Hits	403	Target Neighborhood Hits	142	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

NEDD4_HUMAN
NC score	0.281108 (rank : 171)	θ value	1.74796e-11 (rank : 49)
Query Neighborhood Hits	403	Target Neighborhood Hits	214	Shared Neighborhood Hits	53
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

SDCB2_HUMAN
NC score	0.276827 (rank : 172)	θ value	2.36792 (rank : 306)
Query Neighborhood Hits	403	Target Neighborhood Hits	121	Shared Neighborhood Hits	115
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

NED4L_MOUSE
NC score	0.274723 (rank : 173)	θ value	7.34386e-10 (rank : 63)
Query Neighborhood Hits	403	Target Neighborhood Hits	231	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.274338 (rank : 174)	θ value	7.34386e-10 (rank : 62)
Query Neighborhood Hits	403	Target Neighborhood Hits	238	Shared Neighborhood Hits	56
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
NC score	0.273448 (rank : 175)	θ value	8.11959e-09 (rank : 74)
Query Neighborhood Hits	403	Target Neighborhood Hits	212	Shared Neighborhood Hits	54
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF1_HUMAN
NC score	0.273165 (rank : 176)	θ value	6.21693e-09 (rank : 73)
Query Neighborhood Hits	403	Target Neighborhood Hits	135	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

WWOX_HUMAN
NC score	0.268104 (rank : 177)	θ value	2.61198e-07 (rank : 84)
Query Neighborhood Hits	403	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.265702 (rank : 178)	θ value	2.61198e-07 (rank : 85)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

PDLI5_MOUSE
NC score	0.262127 (rank : 179)	θ value	2.88788e-06 (rank : 93)
Query Neighborhood Hits	403	Target Neighborhood Hits	287	Shared Neighborhood Hits	119
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_HUMAN
NC score	0.261013 (rank : 180)	θ value	6.43352e-06 (rank : 102)
Query Neighborhood Hits	403	Target Neighborhood Hits	322	Shared Neighborhood Hits	120
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

LDB3_MOUSE
NC score	0.260655 (rank : 181)	θ value	6.43352e-06 (rank : 101)
Query Neighborhood Hits	403	Target Neighborhood Hits	510	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LDB3_HUMAN
NC score	0.258510 (rank : 182)	θ value	2.44474e-05 (rank : 118)
Query Neighborhood Hits	403	Target Neighborhood Hits	497	Shared Neighborhood Hits	118
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

GIPC1_MOUSE
NC score	0.257529 (rank : 183)	θ value	0.00228821 (rank : 178)
Query Neighborhood Hits	403	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

NOS1_MOUSE
NC score	0.256266 (rank : 184)	θ value	0.000270298 (rank : 155)
Query Neighborhood Hits	403	Target Neighborhood Hits	155	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDLI7_HUMAN
NC score	0.247071 (rank : 185)	θ value	9.29e-05 (rank : 137)
Query Neighborhood Hits	403	Target Neighborhood Hits	547	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

GIPC1_HUMAN
NC score	0.245337 (rank : 186)	θ value	0.00509761 (rank : 191)
Query Neighborhood Hits	403	Target Neighborhood Hits	91	Shared Neighborhood Hits	88
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

BAG3_HUMAN
NC score	0.240569 (rank : 187)	θ value	0.00228821 (rank : 177)
Query Neighborhood Hits	403	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

PDLI7_MOUSE
NC score	0.237896 (rank : 188)	θ value	9.29e-05 (rank : 138)
Query Neighborhood Hits	403	Target Neighborhood Hits	279	Shared Neighborhood Hits	103
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PKHA5_HUMAN
NC score	0.226340 (rank : 189)	θ value	2.88788e-06 (rank : 94)
Query Neighborhood Hits	403	Target Neighborhood Hits	455	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RIMS1_HUMAN
NC score	0.224093 (rank : 190)	θ value	0.0961366 (rank : 216)
Query Neighborhood Hits	403	Target Neighborhood Hits	437	Shared Neighborhood Hits	158
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

LRRC7_HUMAN
NC score	0.223982 (rank : 191)	θ value	0.000602161 (rank : 162)
Query Neighborhood Hits	403	Target Neighborhood Hits	423	Shared Neighborhood Hits	123
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.222851 (rank : 192)	θ value	0.000602161 (rank : 163)
Query Neighborhood Hits	403	Target Neighborhood Hits	416	Shared Neighborhood Hits	119
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

BAG3_MOUSE
NC score	0.221695 (rank : 193)	θ value	0.00390308 (rank : 186)
Query Neighborhood Hits	403	Target Neighborhood Hits	513	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

SHAN1_HUMAN
NC score	0.219758 (rank : 194)	θ value	4.1701e-05 (rank : 131)
Query Neighborhood Hits	403	Target Neighborhood Hits	1041	Shared Neighborhood Hits	165
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

LAP2_HUMAN
NC score	0.206890 (rank : 195)	θ value	0.0193708 (rank : 203)
Query Neighborhood Hits	403	Target Neighborhood Hits	499	Shared Neighborhood Hits	121
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

CNKR2_MOUSE
NC score	0.206241 (rank : 196)	θ value	0.00175202 (rank : 176)
Query Neighborhood Hits	403	Target Neighborhood Hits	197	Shared Neighborhood Hits	61
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.206075 (rank : 197)	θ value	0.00175202 (rank : 175)
Query Neighborhood Hits	403	Target Neighborhood Hits	197	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PCLO_MOUSE
NC score	0.203868 (rank : 198)	θ value	0.00102713 (rank : 171)
Query Neighborhood Hits	403	Target Neighborhood Hits	2275	Shared Neighborhood Hits	226
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

GIPC2_HUMAN
NC score	0.200259 (rank : 199)	θ value	5.27518 (rank : 348)
Query Neighborhood Hits	403	Target Neighborhood Hits	93	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

RIMS2_MOUSE
NC score	0.198530 (rank : 200)	θ value	0.62314 (rank : 248)
Query Neighborhood Hits	403	Target Neighborhood Hits	376	Shared Neighborhood Hits	143
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
NC score	0.196139 (rank : 201)	θ value	0.62314 (rank : 247)
Query Neighborhood Hits	403	Target Neighborhood Hits	342	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

LAP2_MOUSE
NC score	0.195264 (rank : 202)	θ value	0.0193708 (rank : 204)
Query Neighborhood Hits	403	Target Neighborhood Hits	482	Shared Neighborhood Hits	117
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PINL_HUMAN
NC score	0.185485 (rank : 203)	θ value	3.0926 (rank : 324)
Query Neighborhood Hits	403	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PTN4_HUMAN
NC score	0.166323 (rank : 204)	θ value	0.000786445 (rank : 168)
Query Neighborhood Hits	403	Target Neighborhood Hits	303	Shared Neighborhood Hits	126
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN3_HUMAN
NC score	0.166075 (rank : 205)	θ value	4.1701e-05 (rank : 130)
Query Neighborhood Hits	403	Target Neighborhood Hits	258	Shared Neighborhood Hits	117
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PIN1_MOUSE
NC score	0.165911 (rank : 206)	θ value	1.38821 (rank : 284)
Query Neighborhood Hits	403	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_HUMAN
NC score	0.165125 (rank : 207)	θ value	1.38821 (rank : 283)
Query Neighborhood Hits	403	Target Neighborhood Hits	59	Shared Neighborhood Hits	38
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PDZD6_HUMAN
NC score	0.155901 (rank : 208)	θ value	6.88961 (rank : 376)
Query Neighborhood Hits	403	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

GIPC3_HUMAN
NC score	0.153378 (rank : 209)	θ value	1.06291 (rank : 267)
Query Neighborhood Hits	403	Target Neighborhood Hits	52	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

HUWE1_MOUSE
NC score	0.150989 (rank : 210)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	403	Target Neighborhood Hits	406	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

TRIPC_HUMAN
NC score	0.150759 (rank : 211)	θ value	0.813845 (rank : 263)
Query Neighborhood Hits	403	Target Neighborhood Hits	319	Shared Neighborhood Hits	56
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HUWE1_HUMAN
NC score	0.150452 (rank : 212)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	403	Target Neighborhood Hits	443	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

K0317_HUMAN
NC score	0.149587 (rank : 213)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	403	Target Neighborhood Hits	46	Shared Neighborhood Hits	15
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.149503 (rank : 214)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	403	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

GIPC2_MOUSE
NC score	0.145714 (rank : 215)	θ value	2.36792 (rank : 302)
Query Neighborhood Hits	403	Target Neighborhood Hits	71	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GIPC3_MOUSE
NC score	0.145269 (rank : 216)	θ value	1.06291 (rank : 268)
Query Neighborhood Hits	403	Target Neighborhood Hits	53	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

HECD2_MOUSE
NC score	0.142884 (rank : 217)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	403	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.142026 (rank : 218)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	403	Target Neighborhood Hits	41	Shared Neighborhood Hits	14
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

CSKP_HUMAN
NC score	0.139309 (rank : 219)	θ value	4.1701e-05 (rank : 125)
Query Neighborhood Hits	403	Target Neighborhood Hits	1022	Shared Neighborhood Hits	134
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

UBE3A_HUMAN
NC score	0.138831 (rank : 220)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	403	Target Neighborhood Hits	49	Shared Neighborhood Hits	15
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3C_HUMAN
NC score	0.137054 (rank : 221)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	403	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_MOUSE
NC score	0.137051 (rank : 222)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	403	Target Neighborhood Hits	47	Shared Neighborhood Hits	16
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_MOUSE
NC score	0.136778 (rank : 223)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	403	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

CSKP_MOUSE
NC score	0.136061 (rank : 224)	θ value	4.1701e-05 (rank : 126)
Query Neighborhood Hits	403	Target Neighborhood Hits	1027	Shared Neighborhood Hits	133
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

HERC5_HUMAN
NC score	0.117740 (rank : 225)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	403	Target Neighborhood Hits	66	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.114579 (rank : 226)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	403	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

SRRM2_HUMAN
NC score	0.108073 (rank : 227)	θ value	0.0193708 (rank : 206)
Query Neighborhood Hits	403	Target Neighborhood Hits	1296	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

RGS3_HUMAN
NC score	0.104178 (rank : 228)	θ value	0.000121331 (rank : 142)
Query Neighborhood Hits	403	Target Neighborhood Hits	1375	Shared Neighborhood Hits	122
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

NPBL_MOUSE
NC score	0.103285 (rank : 229)	θ value	0.00035302 (rank : 159)
Query Neighborhood Hits	403	Target Neighborhood Hits	1041	Shared Neighborhood Hits	119
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

EDD1_HUMAN
NC score	0.100581 (rank : 230)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	403	Target Neighborhood Hits	170	Shared Neighborhood Hits	26
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
NC score	0.100440 (rank : 231)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	403	Target Neighborhood Hits	167	Shared Neighborhood Hits	28
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

NIPBL_HUMAN
NC score	0.100274 (rank : 232)	θ value	1.43324e-05 (rank : 111)
Query Neighborhood Hits	403	Target Neighborhood Hits	1311	Shared Neighborhood Hits	120
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

RBBP6_HUMAN
NC score	0.100050 (rank : 233)	θ value	0.00390308 (rank : 188)
Query Neighborhood Hits	403	Target Neighborhood Hits	1135	Shared Neighborhood Hits	108
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

HECD3_MOUSE
NC score	0.099850 (rank : 234)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	403	Target Neighborhood Hits	47	Shared Neighborhood Hits	14
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.098119 (rank : 235)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	403	Target Neighborhood Hits	49	Shared Neighborhood Hits	14
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

SRRM2_MOUSE
NC score	0.097338 (rank : 236)	θ value	0.21417 (rank : 231)
Query Neighborhood Hits	403	Target Neighborhood Hits	1470	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

MY18A_MOUSE
NC score	0.094115 (rank : 237)	θ value	4.1701e-05 (rank : 128)
Query Neighborhood Hits	403	Target Neighborhood Hits	1989	Shared Neighborhood Hits	194
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RGS3_MOUSE
NC score	0.093954 (rank : 238)	θ value	0.365318 (rank : 239)
Query Neighborhood Hits	403	Target Neighborhood Hits	1621	Shared Neighborhood Hits	144
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

HERC2_MOUSE
NC score	0.093324 (rank : 239)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	403	Target Neighborhood Hits	167	Shared Neighborhood Hits	22
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

GAS7_HUMAN
NC score	0.093217 (rank : 240)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	403	Target Neighborhood Hits	258	Shared Neighborhood Hits	51
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

TIAM1_HUMAN
NC score	0.092942 (rank : 241)	θ value	0.365318 (rank : 240)
Query Neighborhood Hits	403	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PDZD8_HUMAN
NC score	0.092766 (rank : 242)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	403	Target Neighborhood Hits	185	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

HERC2_HUMAN
NC score	0.092029 (rank : 243)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	403	Target Neighborhood Hits	163	Shared Neighborhood Hits	20
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

RBBP6_MOUSE
NC score	0.092003 (rank : 244)	θ value	0.000602161 (rank : 164)
Query Neighborhood Hits	403	Target Neighborhood Hits	1014	Shared Neighborhood Hits	92
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

TARA_HUMAN
NC score	0.090656 (rank : 245)	θ value	0.000786445 (rank : 170)
Query Neighborhood Hits	403	Target Neighborhood Hits	1626	Shared Neighborhood Hits	126
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PRP40_HUMAN
NC score	0.089500 (rank : 246)	θ value	8.99809 (rank : 396)
Query Neighborhood Hits	403	Target Neighborhood Hits	442	Shared Neighborhood Hits	74
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.089299 (rank : 247)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	403	Target Neighborhood Hits	447	Shared Neighborhood Hits	76
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

HECD1_HUMAN
NC score	0.089128 (rank : 248)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	403	Target Neighborhood Hits	371	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

GAS7_MOUSE
NC score	0.088834 (rank : 249)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	403	Target Neighborhood Hits	259	Shared Neighborhood Hits	49
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PRAX_MOUSE
NC score	0.088541 (rank : 250)	θ value	5.27518 (rank : 357)
Query Neighborhood Hits	403	Target Neighborhood Hits	199	Shared Neighborhood Hits	49
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

LMO7_HUMAN
NC score	0.088454 (rank : 251)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	403	Target Neighborhood Hits	507	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

WWC3_HUMAN
NC score	0.087666 (rank : 252)	θ value	1.06291 (rank : 275)
Query Neighborhood Hits	403	Target Neighborhood Hits	193	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

MAST4_HUMAN
NC score	0.087164 (rank : 253)	θ value	0.000158464 (rank : 145)
Query Neighborhood Hits	403	Target Neighborhood Hits	1804	Shared Neighborhood Hits	187
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SFRS8_HUMAN
NC score	0.085378 (rank : 254)	θ value	0.000461057 (rank : 161)
Query Neighborhood Hits	403	Target Neighborhood Hits	166	Shared Neighborhood Hits	30
SwissProt Accessions	Q12872	Gene names	SFRS8, SWAP
Domain Architecture
Description	Splicing factor, arginine/serine-rich 8 (Suppressor of white apricot protein homolog).

MY18A_HUMAN
NC score	0.084722 (rank : 255)	θ value	0.000786445 (rank : 166)
Query Neighborhood Hits	403	Target Neighborhood Hits	1929	Shared Neighborhood Hits	196
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MAST2_HUMAN
NC score	0.083874 (rank : 256)	θ value	2.44474e-05 (rank : 119)
Query Neighborhood Hits	403	Target Neighborhood Hits	1189	Shared Neighborhood Hits	145
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST1_MOUSE
NC score	0.083294 (rank : 257)	θ value	1.43324e-05 (rank : 110)
Query Neighborhood Hits	403	Target Neighborhood Hits	1123	Shared Neighborhood Hits	137
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

SRRM1_MOUSE
NC score	0.083227 (rank : 258)	θ value	4.03905 (rank : 342)
Query Neighborhood Hits	403	Target Neighborhood Hits	966	Shared Neighborhood Hits	107
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

MAST3_HUMAN
NC score	0.082901 (rank : 259)	θ value	0.000158464 (rank : 144)
Query Neighborhood Hits	403	Target Neighborhood Hits	1128	Shared Neighborhood Hits	138
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST1_HUMAN
NC score	0.082536 (rank : 260)	θ value	1.43324e-05 (rank : 109)
Query Neighborhood Hits	403	Target Neighborhood Hits	1146	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_MOUSE
NC score	0.081795 (rank : 261)	θ value	7.1131e-05 (rank : 136)
Query Neighborhood Hits	403	Target Neighborhood Hits	1110	Shared Neighborhood Hits	141
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

SFR11_HUMAN
NC score	0.081025 (rank : 262)	θ value	0.21417 (rank : 229)
Query Neighborhood Hits	403	Target Neighborhood Hits	246	Shared Neighborhood Hits	53
SwissProt Accessions	Q05519	Gene names	SFRS11
Domain Architecture
Description	Splicing factor arginine/serine-rich 11 (Arginine-rich 54 kDa nuclear protein) (p54).

APBB2_HUMAN
NC score	0.080961 (rank : 263)	θ value	0.0563607 (rank : 211)
Query Neighborhood Hits	403	Target Neighborhood Hits	96	Shared Neighborhood Hits	27
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

SFRIP_HUMAN
NC score	0.079682 (rank : 264)	θ value	0.21417 (rank : 230)
Query Neighborhood Hits	403	Target Neighborhood Hits	530	Shared Neighborhood Hits	68
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SETD2_HUMAN
NC score	0.079282 (rank : 265)	θ value	1.81305 (rank : 296)
Query Neighborhood Hits	403	Target Neighborhood Hits	412	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SRRM1_HUMAN
NC score	0.076984 (rank : 266)	θ value	0.47712 (rank : 245)
Query Neighborhood Hits	403	Target Neighborhood Hits	690	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

CCD55_HUMAN
NC score	0.076724 (rank : 267)	θ value	0.0563607 (rank : 212)
Query Neighborhood Hits	403	Target Neighborhood Hits	513	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H0G5, Q6FI71	Gene names	CCDC55
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 55.

CNKR1_HUMAN
NC score	0.075493 (rank : 268)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	403	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

RHPN2_MOUSE
NC score	0.075096 (rank : 269)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	403	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

CCD55_MOUSE
NC score	0.074308 (rank : 270)	θ value	0.62314 (rank : 246)
Query Neighborhood Hits	403	Target Neighborhood Hits	519	Shared Neighborhood Hits	76
SwissProt Accessions	Q5NCR9	Gene names	Ccdc55
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 55.

HTRA3_MOUSE
NC score	0.071158 (rank : 271)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	403	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

APBB3_HUMAN
NC score	0.067395 (rank : 272)	θ value	0.365318 (rank : 234)
Query Neighborhood Hits	403	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

TARA_MOUSE
NC score	0.067088 (rank : 273)	θ value	0.163984 (rank : 225)
Query Neighborhood Hits	403	Target Neighborhood Hits	1133	Shared Neighborhood Hits	93
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CAR11_HUMAN
NC score	0.066564 (rank : 274)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	403	Target Neighborhood Hits	690	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

APBB3_MOUSE
NC score	0.066115 (rank : 275)	θ value	0.365318 (rank : 235)
Query Neighborhood Hits	403	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

TIAM1_MOUSE
NC score	0.065999 (rank : 276)	θ value	0.62314 (rank : 251)
Query Neighborhood Hits	403	Target Neighborhood Hits	205	Shared Neighborhood Hits	54
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

HTRA3_HUMAN
NC score	0.065150 (rank : 277)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	403	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

RNF41_MOUSE
NC score	0.063151 (rank : 278)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	403	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_HUMAN
NC score	0.062924 (rank : 279)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	403	Target Neighborhood Hits	226	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

PRAX_HUMAN
NC score	0.062659 (rank : 280)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	403	Target Neighborhood Hits	215	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

VCY1_HUMAN
NC score	0.061193 (rank : 281)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	403	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	O14598	Gene names	VCY, BPY1
Domain Architecture	No domain graphic available
Description	Testis-specific basic protein Y 1 (Variably charged protein Y).

SI1L2_HUMAN
NC score	0.059815 (rank : 282)	θ value	1.81305 (rank : 297)
Query Neighborhood Hits	403	Target Neighborhood Hits	131	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

ZC313_HUMAN
NC score	0.058714 (rank : 283)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	403	Target Neighborhood Hits	772	Shared Neighborhood Hits	77
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

SI1L2_MOUSE
NC score	0.058690 (rank : 284)	θ value	1.81305 (rank : 298)
Query Neighborhood Hits	403	Target Neighborhood Hits	124	Shared Neighborhood Hits	45
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

HIRP3_HUMAN
NC score	0.058170 (rank : 285)	θ value	6.88961 (rank : 372)
Query Neighborhood Hits	403	Target Neighborhood Hits	323	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

CAR14_HUMAN
NC score	0.057511 (rank : 286)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	403	Target Neighborhood Hits	449	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

SFR12_MOUSE
NC score	0.057451 (rank : 287)	θ value	0.47712 (rank : 244)
Query Neighborhood Hits	403	Target Neighborhood Hits	486	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

PCLO_HUMAN
NC score	0.057442 (rank : 288)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	403	Target Neighborhood Hits	2046	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SI1L3_HUMAN
NC score	0.056420 (rank : 289)	θ value	1.81305 (rank : 299)
Query Neighborhood Hits	403	Target Neighborhood Hits	305	Shared Neighborhood Hits	58
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

HTRA1_MOUSE
NC score	0.055808 (rank : 290)	θ value	3.0926 (rank : 318)
Query Neighborhood Hits	403	Target Neighborhood Hits	140	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

SFR17_HUMAN
NC score	0.055293 (rank : 291)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	403	Target Neighborhood Hits	325	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TF01, Q5T064, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8TF00, Q96K10, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3	Gene names	SRRP130, C6orf111
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 130 (Serine-arginine-rich- splicing regulatory protein 130) (SRrp130) (SR-rich protein) (SR- related protein).

HTRA1_HUMAN
NC score	0.055032 (rank : 292)	θ value	8.99809 (rank : 390)
Query Neighborhood Hits	403	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

APBB2_MOUSE
NC score	0.054686 (rank : 293)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	403	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

TGON2_HUMAN
NC score	0.054329 (rank : 294)	θ value	0.62314 (rank : 250)
Query Neighborhood Hits	403	Target Neighborhood Hits	1037	Shared Neighborhood Hits	99
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

PSMD9_HUMAN
NC score	0.054069 (rank : 295)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	403	Target Neighborhood Hits	36	Shared Neighborhood Hits	20
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

FILA_HUMAN
NC score	0.054041 (rank : 296)	θ value	1.06291 (rank : 266)
Query Neighborhood Hits	403	Target Neighborhood Hits	685	Shared Neighborhood Hits	86
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

RAIN_HUMAN
NC score	0.053940 (rank : 297)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	403	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q5U651, Q6U676	Gene names	RASIP1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

TCRG1_MOUSE
NC score	0.053309 (rank : 298)	θ value	2.36792 (rank : 308)
Query Neighborhood Hits	403	Target Neighborhood Hits	947	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

RAIN_MOUSE
NC score	0.053083 (rank : 299)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	403	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

SI1L1_HUMAN
NC score	0.052127 (rank : 300)	θ value	5.27518 (rank : 361)
Query Neighborhood Hits	403	Target Neighborhood Hits	162	Shared Neighborhood Hits	42
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

TCRG1_HUMAN
NC score	0.052082 (rank : 301)	θ value	5.27518 (rank : 363)
Query Neighborhood Hits	403	Target Neighborhood Hits	929	Shared Neighborhood Hits	86
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

SI1L1_MOUSE
NC score	0.051835 (rank : 302)	θ value	5.27518 (rank : 362)
Query Neighborhood Hits	403	Target Neighborhood Hits	189	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SFR12_HUMAN
NC score	0.051494 (rank : 303)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	403	Target Neighborhood Hits	553	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

MDC1_HUMAN
NC score	0.051365 (rank : 304)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	403	Target Neighborhood Hits	1446	Shared Neighborhood Hits	115
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CIR_HUMAN
NC score	0.051291 (rank : 305)	θ value	3.0926 (rank : 312)
Query Neighborhood Hits	403	Target Neighborhood Hits	249	Shared Neighborhood Hits	42
SwissProt Accessions	Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2	Gene names	CIR
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor (Recepin).

RHG12_MOUSE
NC score	0.051100 (rank : 306)	θ value	2.36792 (rank : 305)
Query Neighborhood Hits	403	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

BCLF1_HUMAN
NC score	0.050987 (rank : 307)	θ value	5.27518 (rank : 345)
Query Neighborhood Hits	403	Target Neighborhood Hits	298	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

NOLC1_HUMAN
NC score	0.050613 (rank : 308)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	403	Target Neighborhood Hits	452	Shared Neighborhood Hits	51
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

DSPP_MOUSE
NC score	0.050369 (rank : 309)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	403	Target Neighborhood Hits	491	Shared Neighborhood Hits	54
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

BCLF1_MOUSE
NC score	0.049941 (rank : 310)	θ value	5.27518 (rank : 346)
Query Neighborhood Hits	403	Target Neighborhood Hits	303	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K019, Q8BNZ0, Q8C2E9, Q9CSW5	Gene names	Bclaf1, Btf, Kiaa0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

LAD1_HUMAN
NC score	0.047938 (rank : 311)	θ value	0.279714 (rank : 233)
Query Neighborhood Hits	403	Target Neighborhood Hits	441	Shared Neighborhood Hits	46
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

BAT2_HUMAN
NC score	0.047690 (rank : 312)	θ value	1.38821 (rank : 276)
Query Neighborhood Hits	403	Target Neighborhood Hits	931	Shared Neighborhood Hits	72
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

U2AFM_HUMAN
NC score	0.047334 (rank : 313)	θ value	0.0431538 (rank : 209)
Query Neighborhood Hits	403	Target Neighborhood Hits	577	Shared Neighborhood Hits	46
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

DEK_MOUSE
NC score	0.047234 (rank : 314)	θ value	1.81305 (rank : 288)
Query Neighborhood Hits	403	Target Neighborhood Hits	280	Shared Neighborhood Hits	31
SwissProt Accessions	Q7TNV0, Q80VC5, Q8BZV6	Gene names	Dek
Domain Architecture	No domain graphic available
Description	Protein DEK.

MPP8_HUMAN
NC score	0.047137 (rank : 315)	θ value	5.44631e-05 (rank : 132)
Query Neighborhood Hits	403	Target Neighborhood Hits	948	Shared Neighborhood Hits	72
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

DRP2_HUMAN
NC score	0.046596 (rank : 316)	θ value	6.88961 (rank : 368)
Query Neighborhood Hits	403	Target Neighborhood Hits	186	Shared Neighborhood Hits	28
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

U2AFL_HUMAN
NC score	0.045564 (rank : 317)	θ value	0.0113563 (rank : 196)
Query Neighborhood Hits	403	Target Neighborhood Hits	503	Shared Neighborhood Hits	41
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

MMTA2_MOUSE
NC score	0.045341 (rank : 318)	θ value	0.163984 (rank : 221)
Query Neighborhood Hits	403	Target Neighborhood Hits	40	Shared Neighborhood Hits	13
SwissProt Accessions	Q99LX5, Q9CSK6	Gene names	Mmtag2
Domain Architecture	No domain graphic available
Description	Multiple myeloma tumor-associated protein 2 homolog.

TRDN_HUMAN
NC score	0.045047 (rank : 319)	θ value	1.06291 (rank : 272)
Query Neighborhood Hits	403	Target Neighborhood Hits	542	Shared Neighborhood Hits	53
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

RHG12_HUMAN
NC score	0.044842 (rank : 320)	θ value	8.99809 (rank : 398)
Query Neighborhood Hits	403	Target Neighborhood Hits	190	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

PRR8_HUMAN
NC score	0.044516 (rank : 321)	θ value	0.813845 (rank : 259)
Query Neighborhood Hits	403	Target Neighborhood Hits	217	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

ACINU_HUMAN
NC score	0.044482 (rank : 322)	θ value	4.03905 (rank : 328)
Query Neighborhood Hits	403	Target Neighborhood Hits	828	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

NKTR_HUMAN
NC score	0.043478 (rank : 323)	θ value	0.365318 (rank : 237)
Query Neighborhood Hits	403	Target Neighborhood Hits	658	Shared Neighborhood Hits	81
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

YLPM1_HUMAN
NC score	0.042395 (rank : 324)	θ value	4.03905 (rank : 343)
Query Neighborhood Hits	403	Target Neighborhood Hits	670	Shared Neighborhood Hits	63
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

CROP_HUMAN
NC score	0.041761 (rank : 325)	θ value	3.0926 (rank : 313)
Query Neighborhood Hits	403	Target Neighborhood Hits	402	Shared Neighborhood Hits	46
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

LEO1_HUMAN
NC score	0.040817 (rank : 326)	θ value	0.47712 (rank : 241)
Query Neighborhood Hits	403	Target Neighborhood Hits	958	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

HRG_HUMAN
NC score	0.040471 (rank : 327)	θ value	0.813845 (rank : 257)
Query Neighborhood Hits	403	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	P04196	Gene names	HRG
Domain Architecture
Description	Histidine-rich glycoprotein precursor (Histidine-proline-rich glycoprotein) (HPRG).

PPRB_MOUSE
NC score	0.039480 (rank : 328)	θ value	6.88961 (rank : 377)
Query Neighborhood Hits	403	Target Neighborhood Hits	354	Shared Neighborhood Hits	44
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

RPTN_MOUSE
NC score	0.038882 (rank : 329)	θ value	0.62314 (rank : 249)
Query Neighborhood Hits	403	Target Neighborhood Hits	650	Shared Neighborhood Hits	73
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

NOL3_HUMAN
NC score	0.038064 (rank : 330)	θ value	1.06291 (rank : 270)
Query Neighborhood Hits	403	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	O60936, O60937	Gene names	NOL3, ARC, NOP
Domain Architecture
Description	Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30).

TR150_MOUSE
NC score	0.037938 (rank : 331)	θ value	2.36792 (rank : 309)
Query Neighborhood Hits	403	Target Neighborhood Hits	468	Shared Neighborhood Hits	63
SwissProt Accessions	Q569Z6	Gene names	Thrap3, Trap150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

LIMK1_MOUSE
NC score	0.037579 (rank : 332)	θ value	4.03905 (rank : 336)
Query Neighborhood Hits	403	Target Neighborhood Hits	1008	Shared Neighborhood Hits	88
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK1_HUMAN
NC score	0.037489 (rank : 333)	θ value	4.03905 (rank : 335)
Query Neighborhood Hits	403	Target Neighborhood Hits	1005	Shared Neighborhood Hits	87
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

TXND2_MOUSE
NC score	0.037367 (rank : 334)	θ value	3.0926 (rank : 325)
Query Neighborhood Hits	403	Target Neighborhood Hits	828	Shared Neighborhood Hits	77
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

PRB3_HUMAN
NC score	0.037049 (rank : 335)	θ value	5.27518 (rank : 358)
Query Neighborhood Hits	403	Target Neighborhood Hits	318	Shared Neighborhood Hits	31
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

AFF4_HUMAN
NC score	0.036173 (rank : 336)	θ value	8.99809 (rank : 384)
Query Neighborhood Hits	403	Target Neighborhood Hits	611	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

MRIP_MOUSE
NC score	0.036113 (rank : 337)	θ value	2.36792 (rank : 304)
Query Neighborhood Hits	403	Target Neighborhood Hits	569	Shared Neighborhood Hits	29
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

RPTN_HUMAN
NC score	0.036033 (rank : 338)	θ value	0.813845 (rank : 260)
Query Neighborhood Hits	403	Target Neighborhood Hits	406	Shared Neighborhood Hits	55
SwissProt Accessions	Q6XPR3	Gene names	RPTN
Domain Architecture	No domain graphic available
Description	Repetin.

PPRB_HUMAN
NC score	0.035502 (rank : 339)	θ value	8.99809 (rank : 395)
Query Neighborhood Hits	403	Target Neighborhood Hits	311	Shared Neighborhood Hits	39
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

RBM15_HUMAN
NC score	0.035038 (rank : 340)	θ value	0.365318 (rank : 238)
Query Neighborhood Hits	403	Target Neighborhood Hits	309	Shared Neighborhood Hits	38
SwissProt Accessions	Q96T37, Q5D058, Q96PE4, Q96SC5, Q96SC6, Q96SC9, Q96SD0, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0	Gene names	RBM15, OTT
Domain Architecture
Description	Putative RNA-binding protein 15 (RNA-binding motif protein 15) (One- twenty two protein).

ANK2_HUMAN
NC score	0.034399 (rank : 341)	θ value	0.0563607 (rank : 210)
Query Neighborhood Hits	403	Target Neighborhood Hits	1615	Shared Neighborhood Hits	117
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

PHF20_MOUSE
NC score	0.033263 (rank : 342)	θ value	1.06291 (rank : 271)
Query Neighborhood Hits	403	Target Neighborhood Hits	513	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

HNRL1_MOUSE
NC score	0.032982 (rank : 343)	θ value	5.27518 (rank : 349)
Query Neighborhood Hits	403	Target Neighborhood Hits	200	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

LEO1_MOUSE
NC score	0.032763 (rank : 344)	θ value	5.27518 (rank : 350)
Query Neighborhood Hits	403	Target Neighborhood Hits	946	Shared Neighborhood Hits	73
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

TOP1_MOUSE
NC score	0.032450 (rank : 345)	θ value	0.813845 (rank : 262)
Query Neighborhood Hits	403	Target Neighborhood Hits	213	Shared Neighborhood Hits	32
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

NU214_HUMAN
NC score	0.030726 (rank : 346)	θ value	8.99809 (rank : 391)
Query Neighborhood Hits	403	Target Neighborhood Hits	657	Shared Neighborhood Hits	46
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

BLNK_MOUSE
NC score	0.030339 (rank : 347)	θ value	0.279714 (rank : 232)
Query Neighborhood Hits	403	Target Neighborhood Hits	296	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

MLL2_HUMAN
NC score	0.030188 (rank : 348)	θ value	2.36792 (rank : 303)
Query Neighborhood Hits	403	Target Neighborhood Hits	1788	Shared Neighborhood Hits	87
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

DDX46_MOUSE
NC score	0.030128 (rank : 349)	θ value	0.0148317 (rank : 198)
Query Neighborhood Hits	403	Target Neighborhood Hits	358	Shared Neighborhood Hits	48
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

LIMK2_MOUSE
NC score	0.029988 (rank : 350)	θ value	1.81305 (rank : 292)
Query Neighborhood Hits	403	Target Neighborhood Hits	998	Shared Neighborhood Hits	76
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

DDX46_HUMAN
NC score	0.029805 (rank : 351)	θ value	0.0148317 (rank : 197)
Query Neighborhood Hits	403	Target Neighborhood Hits	357	Shared Neighborhood Hits	46
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

MLL3_HUMAN
NC score	0.029346 (rank : 352)	θ value	5.27518 (rank : 352)
Query Neighborhood Hits	403	Target Neighborhood Hits	1644	Shared Neighborhood Hits	94
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

DMD_HUMAN
NC score	0.029255 (rank : 353)	θ value	1.81305 (rank : 289)
Query Neighborhood Hits	403	Target Neighborhood Hits	1135	Shared Neighborhood Hits	60
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
NC score	0.028509 (rank : 354)	θ value	1.81305 (rank : 290)
Query Neighborhood Hits	403	Target Neighborhood Hits	1111	Shared Neighborhood Hits	68
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

TF3C1_MOUSE
NC score	0.027483 (rank : 355)	θ value	0.813845 (rank : 261)
Query Neighborhood Hits	403	Target Neighborhood Hits	92	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K284, Q8CAL9	Gene names	Gtf3c1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

TRM1_HUMAN
NC score	0.026347 (rank : 356)	θ value	1.81305 (rank : 300)
Query Neighborhood Hits	403	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXH9, O76103, Q548Y5, Q8WVA6	Gene names	TRMT1
Domain Architecture
Description	N(2),N(2)-dimethylguanosine tRNA methyltransferase (EC 2.1.1.32) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA 2,2- dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase).

REXO1_HUMAN
NC score	0.026294 (rank : 357)	θ value	8.99809 (rank : 397)
Query Neighborhood Hits	403	Target Neighborhood Hits	242	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

IF3A_HUMAN
NC score	0.026192 (rank : 358)	θ value	6.88961 (rank : 373)
Query Neighborhood Hits	403	Target Neighborhood Hits	875	Shared Neighborhood Hits	57
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

CCNK_MOUSE
NC score	0.025731 (rank : 359)	θ value	1.81305 (rank : 286)
Query Neighborhood Hits	403	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

PTPRG_MOUSE
NC score	0.025489 (rank : 360)	θ value	0.163984 (rank : 224)
Query Neighborhood Hits	403	Target Neighborhood Hits	260	Shared Neighborhood Hits	13
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

FIP1_HUMAN
NC score	0.025100 (rank : 361)	θ value	5.27518 (rank : 347)
Query Neighborhood Hits	403	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

CENPT_MOUSE
NC score	0.024484 (rank : 362)	θ value	3.0926 (rank : 311)
Query Neighborhood Hits	403	Target Neighborhood Hits	115	Shared Neighborhood Hits	16
SwissProt Accessions	Q3TJM4, Q3TPY6, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9	Gene names	Cenpt
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T).

ATN1_HUMAN
NC score	0.024406 (rank : 363)	θ value	8.99809 (rank : 385)
Query Neighborhood Hits	403	Target Neighborhood Hits	676	Shared Neighborhood Hits	50
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

UTRO_HUMAN
NC score	0.024401 (rank : 364)	θ value	6.88961 (rank : 381)
Query Neighborhood Hits	403	Target Neighborhood Hits	960	Shared Neighborhood Hits	59
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

NFH_HUMAN
NC score	0.024162 (rank : 365)	θ value	5.27518 (rank : 354)
Query Neighborhood Hits	403	Target Neighborhood Hits	1242	Shared Neighborhood Hits	87
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

DNL1_HUMAN
NC score	0.023857 (rank : 366)	θ value	8.99809 (rank : 387)
Query Neighborhood Hits	403	Target Neighborhood Hits	216	Shared Neighborhood Hits	32
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

ELOA1_MOUSE
NC score	0.023272 (rank : 367)	θ value	8.99809 (rank : 388)
Query Neighborhood Hits	403	Target Neighborhood Hits	152	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CB77, Q80VB2, Q9R0Q5	Gene names	Tceb3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

CN102_HUMAN
NC score	0.023155 (rank : 368)	θ value	0.813845 (rank : 254)
Query Neighborhood Hits	403	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H7Z3, Q9NWH6	Gene names	C14orf102
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf102.

CROCC_MOUSE
NC score	0.022904 (rank : 369)	θ value	1.38821 (rank : 280)
Query Neighborhood Hits	403	Target Neighborhood Hits	1460	Shared Neighborhood Hits	76
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

LSR_HUMAN
NC score	0.022869 (rank : 370)	θ value	0.813845 (rank : 258)
Query Neighborhood Hits	403	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q86X29, O00112, O00426, Q6ZT80, Q9UQL3	Gene names	LSR, LISCH
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor.

EDAR_HUMAN
NC score	0.022304 (rank : 371)	θ value	0.813845 (rank : 255)
Query Neighborhood Hits	403	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

IF3A_MOUSE
NC score	0.022052 (rank : 372)	θ value	4.03905 (rank : 334)
Query Neighborhood Hits	403	Target Neighborhood Hits	871	Shared Neighborhood Hits	58
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

RECQ5_HUMAN
NC score	0.021991 (rank : 373)	θ value	1.81305 (rank : 293)
Query Neighborhood Hits	403	Target Neighborhood Hits	390	Shared Neighborhood Hits	34
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

THSD1_MOUSE
NC score	0.021913 (rank : 374)	θ value	0.163984 (rank : 226)
Query Neighborhood Hits	403	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

RRBP1_HUMAN
NC score	0.021784 (rank : 375)	θ value	4.03905 (rank : 340)
Query Neighborhood Hits	403	Target Neighborhood Hits	1306	Shared Neighborhood Hits	78
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

MCES_HUMAN
NC score	0.021251 (rank : 376)	θ value	4.03905 (rank : 337)
Query Neighborhood Hits	403	Target Neighborhood Hits	134	Shared Neighborhood Hits	19
SwissProt Accessions	O43148, O94996, Q9UIJ9	Gene names	RNMT, KIAA0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase) (hcm1p) (hCMT1) (hMet).

AP2A_HUMAN
NC score	0.021132 (rank : 377)	θ value	0.813845 (rank : 252)
Query Neighborhood Hits	403	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P05549, Q13777	Gene names	TFAP2A, AP2TF, TFAP2
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (AP-2 transcription factor) (Activator protein 2) (AP-2).

CAC1A_MOUSE
NC score	0.020921 (rank : 378)	θ value	0.21417 (rank : 227)
Query Neighborhood Hits	403	Target Neighborhood Hits	267	Shared Neighborhood Hits	35
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

RNF25_HUMAN
NC score	0.020719 (rank : 379)	θ value	5.27518 (rank : 360)
Query Neighborhood Hits	403	Target Neighborhood Hits	163	Shared Neighborhood Hits	16
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

AP2A_MOUSE
NC score	0.020602 (rank : 380)	θ value	0.813845 (rank : 253)
Query Neighborhood Hits	403	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	P34056, Q60740, Q60741, Q60742, Q60743, Q62067, Q62068, Q62069, Q91VX0, Q9CRY4	Gene names	Tfap2a, Ap2tf, Tcfap2a
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (Activator protein 2) (AP-2).

RNC_HUMAN
NC score	0.020404 (rank : 381)	θ value	8.99809 (rank : 399)
Query Neighborhood Hits	403	Target Neighborhood Hits	176	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

LUZP1_MOUSE
NC score	0.019886 (rank : 382)	θ value	6.88961 (rank : 375)
Query Neighborhood Hits	403	Target Neighborhood Hits	940	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

COA2_HUMAN
NC score	0.019649 (rank : 383)	θ value	1.38821 (rank : 279)
Query Neighborhood Hits	403	Target Neighborhood Hits	184	Shared Neighborhood Hits	25
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

DMN_HUMAN
NC score	0.019193 (rank : 384)	θ value	3.0926 (rank : 314)
Query Neighborhood Hits	403	Target Neighborhood Hits	690	Shared Neighborhood Hits	58
SwissProt Accessions	O15061	Gene names	DMN, KIAA0353
Domain Architecture
Description	Desmuslin.

CTRO_MOUSE
NC score	0.019088 (rank : 385)	θ value	4.03905 (rank : 333)
Query Neighborhood Hits	403	Target Neighborhood Hits	2344	Shared Neighborhood Hits	91
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

PO6F2_MOUSE
NC score	0.018819 (rank : 386)	θ value	4.03905 (rank : 339)
Query Neighborhood Hits	403	Target Neighborhood Hits	639	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

CTRO_HUMAN
NC score	0.018663 (rank : 387)	θ value	0.163984 (rank : 220)
Query Neighborhood Hits	403	Target Neighborhood Hits	2092	Shared Neighborhood Hits	75
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

WASF3_MOUSE
NC score	0.017586 (rank : 388)	θ value	1.06291 (rank : 274)
Query Neighborhood Hits	403	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

XRCC1_MOUSE
NC score	0.017577 (rank : 389)	θ value	6.88961 (rank : 382)
Query Neighborhood Hits	403	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

BTBD7_HUMAN
NC score	0.017558 (rank : 390)	θ value	1.38821 (rank : 277)
Query Neighborhood Hits	403	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P203, Q69Z05, Q7Z308, Q86TS0, Q9HAA4, Q9NVM0	Gene names	BTBD7, KIAA1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

DNMT1_MOUSE
NC score	0.017174 (rank : 391)	θ value	3.0926 (rank : 315)
Query Neighborhood Hits	403	Target Neighborhood Hits	137	Shared Neighborhood Hits	16
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

COHA1_HUMAN
NC score	0.017076 (rank : 392)	θ value	4.03905 (rank : 331)
Query Neighborhood Hits	403	Target Neighborhood Hits	400	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

PPIP2_HUMAN
NC score	0.016814 (rank : 393)	θ value	5.27518 (rank : 356)
Query Neighborhood Hits	403	Target Neighborhood Hits	254	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

MRCKB_MOUSE
NC score	0.016337 (rank : 394)	θ value	3.0926 (rank : 320)
Query Neighborhood Hits	403	Target Neighborhood Hits	2180	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

A2BP1_HUMAN
NC score	0.013695 (rank : 395)	θ value	3.0926 (rank : 310)
Query Neighborhood Hits	403	Target Neighborhood Hits	229	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NWB1, Q9NS20	Gene names	A2BP1, A2BP
Domain Architecture
Description	Ataxin-2-binding protein 1.

AP3B2_HUMAN
NC score	0.013149 (rank : 396)	θ value	4.03905 (rank : 329)
Query Neighborhood Hits	403	Target Neighborhood Hits	246	Shared Neighborhood Hits	32
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

CCNT2_HUMAN
NC score	0.013148 (rank : 397)	θ value	6.88961 (rank : 366)
Query Neighborhood Hits	403	Target Neighborhood Hits	84	Shared Neighborhood Hits	16
SwissProt Accessions	O60583, O60582, Q5I1Y0	Gene names	CCNT2
Domain Architecture
Description	Cyclin-T2 (CycT2).

PIBF1_HUMAN
NC score	0.012891 (rank : 398)	θ value	8.99809 (rank : 394)
Query Neighborhood Hits	403	Target Neighborhood Hits	1041	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

DLGP3_HUMAN
NC score	0.012708 (rank : 399)	θ value	1.06291 (rank : 265)
Query Neighborhood Hits	403	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	O95886, Q5TDD5, Q9H3X7	Gene names	DLGAP3, DAP3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

ZC11A_HUMAN
NC score	0.012358 (rank : 400)	θ value	4.03905 (rank : 344)
Query Neighborhood Hits	403	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	O75152, Q6AHY4, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7	Gene names	ZC3H11A, KIAA0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

PCBP3_MOUSE
NC score	0.012340 (rank : 401)	θ value	3.0926 (rank : 322)
Query Neighborhood Hits	403	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	P57722, Q8BSB0, Q8C544	Gene names	Pcbp3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

PCBP3_HUMAN
NC score	0.012337 (rank : 402)	θ value	3.0926 (rank : 321)
Query Neighborhood Hits	403	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	P57721, Q8N9K6, Q96EP6	Gene names	PCBP3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

GRPE1_MOUSE
NC score	0.012103 (rank : 403)	θ value	3.0926 (rank : 316)
Query Neighborhood Hits	403	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q99LP6, Q3TSZ3	Gene names	Grpel1
Domain Architecture	No domain graphic available
Description	GrpE protein homolog 1, mitochondrial precursor (Mt-GrpE#1).

UBF1_HUMAN
NC score	0.011851 (rank : 404)	θ value	6.88961 (rank : 380)
Query Neighborhood Hits	403	Target Neighborhood Hits	415	Shared Neighborhood Hits	30
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

SHD_HUMAN
NC score	0.011538 (rank : 405)	θ value	2.36792 (rank : 307)
Query Neighborhood Hits	403	Target Neighborhood Hits	204	Shared Neighborhood Hits	7
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

BAG1_MOUSE
NC score	0.011256 (rank : 406)	θ value	6.88961 (rank : 364)
Query Neighborhood Hits	403	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q60739	Gene names	Bag1
Domain Architecture
Description	BAG family molecular chaperone regulator 1 (BCL-2-binding athanogene- 1) (BAG-1).

CD2L1_HUMAN
NC score	0.010965 (rank : 407)	θ value	1.06291 (rank : 264)
Query Neighborhood Hits	403	Target Neighborhood Hits	1467	Shared Neighborhood Hits	65
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

MRP6_HUMAN
NC score	0.010569 (rank : 408)	θ value	0.365318 (rank : 236)
Query Neighborhood Hits	403	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	O95255, P78420, Q9UMZ7	Gene names	ABCC6, ARA, MRP6
Domain Architecture
Description	Multidrug resistance-associated protein 6 (ATP-binding cassette sub- family C member 6) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter-E) (MOAT-E).

VINEX_MOUSE
NC score	0.010114 (rank : 409)	θ value	1.06291 (rank : 273)
Query Neighborhood Hits	403	Target Neighborhood Hits	286	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

CD2L1_MOUSE
NC score	0.010037 (rank : 410)	θ value	1.38821 (rank : 278)
Query Neighborhood Hits	403	Target Neighborhood Hits	1463	Shared Neighborhood Hits	70
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

BSPRY_MOUSE
NC score	0.009586 (rank : 411)	θ value	4.03905 (rank : 330)
Query Neighborhood Hits	403	Target Neighborhood Hits	163	Shared Neighborhood Hits	11
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

MCF2L_MOUSE
NC score	0.009010 (rank : 412)	θ value	5.27518 (rank : 351)
Query Neighborhood Hits	403	Target Neighborhood Hits	255	Shared Neighborhood Hits	10
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

CHD6_HUMAN
NC score	0.008679 (rank : 413)	θ value	1.81305 (rank : 287)
Query Neighborhood Hits	403	Target Neighborhood Hits	342	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

CAC1B_HUMAN
NC score	0.008556 (rank : 414)	θ value	6.88961 (rank : 365)
Query Neighborhood Hits	403	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

TXND4_MOUSE
NC score	0.008481 (rank : 415)	θ value	3.0926 (rank : 326)
Query Neighborhood Hits	403	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D1Q6, Q3TVI1, Q6A045	Gene names	Txndc4, Erp44, Kiaa0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

EHMT2_MOUSE
NC score	0.007730 (rank : 416)	θ value	6.88961 (rank : 369)
Query Neighborhood Hits	403	Target Neighborhood Hits	750	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ETV3_HUMAN
NC score	0.006828 (rank : 417)	θ value	6.88961 (rank : 370)
Query Neighborhood Hits	403	Target Neighborhood Hits	312	Shared Neighborhood Hits	27
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

LEG9_MOUSE
NC score	0.006805 (rank : 418)	θ value	3.0926 (rank : 319)
Query Neighborhood Hits	403	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	O08573, O08572	Gene names	Lgals9
Domain Architecture
Description	Galectin-9.

PGCA_HUMAN
NC score	0.006536 (rank : 419)	θ value	3.0926 (rank : 323)
Query Neighborhood Hits	403	Target Neighborhood Hits	821	Shared Neighborhood Hits	31
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

A2BP1_MOUSE
NC score	0.006052 (rank : 420)	θ value	8.99809 (rank : 383)
Query Neighborhood Hits	403	Target Neighborhood Hits	226	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JJ43, Q9JJB5	Gene names	A2bp1, A2bp
Domain Architecture
Description	Ataxin-2-binding protein 1.

CDK4_MOUSE
NC score	0.005538 (rank : 421)	θ value	6.88961 (rank : 367)
Query Neighborhood Hits	403	Target Neighborhood Hits	838	Shared Neighborhood Hits	20
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

RBL2_HUMAN
NC score	0.005418 (rank : 422)	θ value	5.27518 (rank : 359)
Query Neighborhood Hits	403	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q08999, Q15073, Q16084, Q92812	Gene names	RBL2, RB2
Domain Architecture
Description	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).

ZF106_HUMAN
NC score	0.005075 (rank : 423)	θ value	8.99809 (rank : 402)
Query Neighborhood Hits	403	Target Neighborhood Hits	470	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

EMSY_HUMAN
NC score	0.004943 (rank : 424)	θ value	8.99809 (rank : 389)
Query Neighborhood Hits	403	Target Neighborhood Hits	296	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

RFFL_HUMAN
NC score	0.004541 (rank : 425)	θ value	6.88961 (rank : 378)
Query Neighborhood Hits	403	Target Neighborhood Hits	175	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

UBP8_MOUSE
NC score	0.004517 (rank : 426)	θ value	8.99809 (rank : 401)
Query Neighborhood Hits	403	Target Neighborhood Hits	362	Shared Neighborhood Hits	37
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

NEK3_HUMAN
NC score	0.004500 (rank : 427)	θ value	1.38821 (rank : 282)
Query Neighborhood Hits	403	Target Neighborhood Hits	865	Shared Neighborhood Hits	21
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

ZNFX1_MOUSE
NC score	0.004471 (rank : 428)	θ value	8.99809 (rank : 403)
Query Neighborhood Hits	403	Target Neighborhood Hits	407	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

PGCA_MOUSE
NC score	0.003791 (rank : 429)	θ value	8.99809 (rank : 393)
Query Neighborhood Hits	403	Target Neighborhood Hits	643	Shared Neighborhood Hits	24
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

MYEF2_HUMAN
NC score	0.003700 (rank : 430)	θ value	4.03905 (rank : 338)
Query Neighborhood Hits	403	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P2K5, Q6NUM5, Q7L388, Q7Z4B7, Q9H922, Q9NUQ1	Gene names	MYEF2, KIAA1341
Domain Architecture	No domain graphic available
Description	Myelin expression factor 2 (MyEF-2) (MST156).

KTNA1_MOUSE
NC score	0.003376 (rank : 431)	θ value	1.81305 (rank : 291)
Query Neighborhood Hits	403	Target Neighborhood Hits	123	Shared Neighborhood Hits	11
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

DSG1_HUMAN
NC score	0.002266 (rank : 432)	θ value	0.21417 (rank : 228)
Query Neighborhood Hits	403	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q02413	Gene names	DSG1
Domain Architecture
Description	Desmoglein-1 precursor (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen).

MRP7_HUMAN
NC score	0.002149 (rank : 433)	θ value	5.27518 (rank : 353)
Query Neighborhood Hits	403	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T3U5, Q8NHX7, Q9H7N2, Q9NXY3, Q9UF48	Gene names	ABCC10, MRP7, SIMRP7
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 7 (ATP-binding cassette sub- family C member 10).

BACH1_MOUSE
NC score	0.001938 (rank : 434)	θ value	2.36792 (rank : 301)
Query Neighborhood Hits	403	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	P97302	Gene names	Bach1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1).

SIM1_MOUSE
NC score	0.001632 (rank : 435)	θ value	6.88961 (rank : 379)
Query Neighborhood Hits	403	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

NRG2_HUMAN
NC score	0.001535 (rank : 436)	θ value	5.27518 (rank : 355)
Query Neighborhood Hits	403	Target Neighborhood Hits	419	Shared Neighborhood Hits	13
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

GBRD_HUMAN
NC score	0.001515 (rank : 437)	θ value	1.38821 (rank : 281)
Query Neighborhood Hits	403	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	O14764, Q8N4N9	Gene names	GABRD
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit delta precursor (GABA(A) receptor subunit delta).

SMP1L_MOUSE
NC score	0.001095 (rank : 438)	θ value	8.99809 (rank : 400)
Query Neighborhood Hits	403	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CSPG3_MOUSE
NC score	0.000309 (rank : 439)	θ value	4.03905 (rank : 332)
Query Neighborhood Hits	403	Target Neighborhood Hits	657	Shared Neighborhood Hits	24
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

HHEX_HUMAN
NC score	0.000303 (rank : 440)	θ value	3.0926 (rank : 317)
Query Neighborhood Hits	403	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	Q03014	Gene names	HHEX, HEX, PRH, PRHX
Domain Architecture
Description	Homeobox protein PRH (Hematopoietically expressed homeobox) (Homeobox protein HEX).

COEA1_HUMAN
NC score	0.000288 (rank : 441)	θ value	8.99809 (rank : 386)
Query Neighborhood Hits	403	Target Neighborhood Hits	427	Shared Neighborhood Hits	19
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

FOXGB_HUMAN
NC score	-0.001079 (rank : 442)	θ value	6.88961 (rank : 371)
Query Neighborhood Hits	403	Target Neighborhood Hits	123	Shared Neighborhood Hits	5
SwissProt Accessions	P55315	Gene names	FOXG1B, FKHL1
Domain Architecture
Description	Forkhead box protein G1B (Forkhead-related protein FKHL1) (Transcription factor BF-1) (Brain factor 1) (BF1) (HFK1).

ZEP1_HUMAN
NC score	-0.001508 (rank : 443)	θ value	1.38821 (rank : 285)
Query Neighborhood Hits	403	Target Neighborhood Hits	1036	Shared Neighborhood Hits	30
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

PEG3_MOUSE
NC score	-0.004045 (rank : 444)	θ value	8.99809 (rank : 392)
Query Neighborhood Hits	403	Target Neighborhood Hits	1101	Shared Neighborhood Hits	56
SwissProt Accessions	Q3URU2, O54978, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53	Gene names	Peg3, Kiaa0287, Pw1
Domain Architecture	No domain graphic available
Description	Paternally expressed gene 3 protein (ASF-1).

EDNRB_HUMAN
NC score	-0.004493 (rank : 445)	θ value	0.813845 (rank : 256)
Query Neighborhood Hits	403	Target Neighborhood Hits	598	Shared Neighborhood Hits	3
SwissProt Accessions	P24530, O15343, Q9UQK3	Gene names	EDNRB, ETRB
Domain Architecture
Description	Endothelin B receptor precursor (ET-B) (Endothelin receptor Non- selective type).

LRP1B_HUMAN
NC score	-0.004606 (rank : 446)	θ value	6.88961 (rank : 374)
Query Neighborhood Hits	403	Target Neighborhood Hits	602	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

MTR1L_MOUSE
NC score	-0.006955 (rank : 447)	θ value	1.06291 (rank : 269)
Query Neighborhood Hits	403	Target Neighborhood Hits	903	Shared Neighborhood Hits	5
SwissProt Accessions	O88495	Gene names	Gpr50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

ZN575_HUMAN
NC score	-0.010476 (rank : 448)	θ value	3.0926 (rank : 327)
Query Neighborhood Hits	403	Target Neighborhood Hits	739	Shared Neighborhood Hits	9
SwissProt Accessions	Q86XF7	Gene names	ZNF575
Domain Architecture	No domain graphic available
Description	Zinc finger protein 575.