Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : APBB3_HUMAN

For an explanation of this page, click here

APBB3_HUMAN
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APBB3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
θ value	0 (rank : 2)	NC score	0.998396 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

APBB2_HUMAN
θ value	1.48926e-103 (rank : 3)	NC score	0.937955 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	96	Shared Neighborhood Hits	25
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
θ value	1.48926e-103 (rank : 4)	NC score	0.940212 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB1_MOUSE
θ value	3.1125e-93 (rank : 5)	NC score	0.938039 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_HUMAN
θ value	2.01746e-92 (rank : 6)	NC score	0.940103 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

SETD2_HUMAN
θ value	0.00175202 (rank : 7)	NC score	0.150940 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	412	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

NED4L_HUMAN
θ value	0.0193708 (rank : 8)	NC score	0.121828 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	238	Shared Neighborhood Hits	27
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	0.0193708 (rank : 9)	NC score	0.120378 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
θ value	0.0252991 (rank : 10)	NC score	0.125325 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	214	Shared Neighborhood Hits	27
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
θ value	0.125558 (rank : 11)	NC score	0.120988 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	212	Shared Neighborhood Hits	27
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

WWP1_MOUSE
θ value	0.125558 (rank : 12)	NC score	0.128743 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	138	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP1_HUMAN
θ value	0.163984 (rank : 13)	NC score	0.133918 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	262	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP2_HUMAN
θ value	0.163984 (rank : 14)	NC score	0.134114 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	177	Shared Neighborhood Hits	27
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	0.163984 (rank : 15)	NC score	0.146243 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

PQBP1_MOUSE
θ value	0.21417 (rank : 16)	NC score	0.075358 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	Q91VJ5, Q80WW2, Q9ER43, Q9QYY2	Gene names	Pqbp1, Npw38
Domain Architecture	No domain graphic available
Description	Polyglutamine-binding protein 1 (Polyglutamine tract-binding protein 1) (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38).

MAGI1_MOUSE
θ value	0.365318 (rank : 17)	NC score	0.067395 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	403	Shared Neighborhood Hits	22
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
θ value	0.47712 (rank : 18)	NC score	0.067860 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	388	Shared Neighborhood Hits	22
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

GAS7_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.101002 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PIN1_HUMAN
θ value	1.06291 (rank : 20)	NC score	0.144878 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PQBP1_HUMAN
θ value	1.06291 (rank : 21)	NC score	0.066740 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	O60828, Q4VY25, Q4VY26, Q4VY27, Q4VY29, Q4VY30, Q4VY34, Q4VY35, Q4VY36, Q4VY37, Q4VY38, Q9GZP2, Q9GZU4, Q9GZZ4	Gene names	PQBP1, NPW38
Domain Architecture	No domain graphic available
Description	Polyglutamine-binding protein 1 (Polyglutamine tract-binding protein 1) (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38).

CJ030_HUMAN
θ value	1.38821 (rank : 22)	NC score	0.029189 (rank : 50)
Query Neighborhood Hits	36	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N7W2, Q5SYY7, Q5SYY8, Q5SYY9, Q8N5T7	Gene names	C10orf30
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf30.

ITCH_HUMAN
θ value	1.38821 (rank : 23)	NC score	0.112418 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	162	Shared Neighborhood Hits	25
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	1.38821 (rank : 24)	NC score	0.115648 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	127	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

STS_MOUSE
θ value	1.38821 (rank : 25)	NC score	0.021465 (rank : 51)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

SAV1_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.092917 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	51	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SMUF2_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.116322 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

OSBL5_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.013324 (rank : 52)
Query Neighborhood Hits	36	Target Neighborhood Hits	117	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

PIN1_MOUSE
θ value	2.36792 (rank : 29)	NC score	0.160027 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

SAV1_MOUSE
θ value	2.36792 (rank : 30)	NC score	0.086904 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	48	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

GAS7_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.086854 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	259	Shared Neighborhood Hits	23
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SMO_MOUSE
θ value	4.03905 (rank : 32)	NC score	0.009396 (rank : 54)
Query Neighborhood Hits	36	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

IKKE_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.001320 (rank : 55)
Query Neighborhood Hits	36	Target Neighborhood Hits	837	Shared Neighborhood Hits	3
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

PINL_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.155376 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	47	Shared Neighborhood Hits	27
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

FA84B_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.011393 (rank : 53)
Query Neighborhood Hits	36	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q96KN1	Gene names	FAM84B, NSE2
Domain Architecture	No domain graphic available
Description	Protein FAM84B (Protein NSE2) (Breast cancer membrane protein 101).

ZN692_HUMAN
θ value	8.99809 (rank : 36)	NC score	-0.001172 (rank : 56)
Query Neighborhood Hits	36	Target Neighborhood Hits	808	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BU19, Q5SRA5, Q5SRA6, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97	Gene names	ZNF692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

HECD2_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.060601 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.060880 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC5_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.051151 (rank : 45)
Query Neighborhood Hits	36	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.061788 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	443	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.069899 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	406	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

JIP1_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.050439 (rank : 48)
Query Neighborhood Hits	36	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

K0317_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.064850 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.064812 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

SMUF1_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.077074 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.086113 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	142	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

TRIPC_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.054090 (rank : 44)
Query Neighborhood Hits	36	Target Neighborhood Hits	319	Shared Neighborhood Hits	12
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.059487 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.058831 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.058967 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.058838 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	48	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WWC1_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.050727 (rank : 47)
Query Neighborhood Hits	36	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.050136 (rank : 49)
Query Neighborhood Hits	36	Target Neighborhood Hits	290	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWTR1_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.051001 (rank : 46)
Query Neighborhood Hits	36	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.071723 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	173	Shared Neighborhood Hits	23
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YAP1_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.082548 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	96	Shared Neighborhood Hits	23
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

APBB3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
NC score	0.998396 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

APBB2_MOUSE
NC score	0.940212 (rank : 3)	θ value	1.48926e-103 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB1_HUMAN
NC score	0.940103 (rank : 4)	θ value	2.01746e-92 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.938039 (rank : 5)	θ value	3.1125e-93 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB2_HUMAN
NC score	0.937955 (rank : 6)	θ value	1.48926e-103 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	96	Shared Neighborhood Hits	25
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

PIN1_MOUSE
NC score	0.160027 (rank : 7)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PINL_HUMAN
NC score	0.155376 (rank : 8)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	47	Shared Neighborhood Hits	27
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

SETD2_HUMAN
NC score	0.150940 (rank : 9)	θ value	0.00175202 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	412	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

WWP2_MOUSE
NC score	0.146243 (rank : 10)	θ value	0.163984 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

PIN1_HUMAN
NC score	0.144878 (rank : 11)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWP2_HUMAN
NC score	0.134114 (rank : 12)	θ value	0.163984 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	177	Shared Neighborhood Hits	27
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_HUMAN
NC score	0.133918 (rank : 13)	θ value	0.163984 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	262	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
NC score	0.128743 (rank : 14)	θ value	0.125558 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	138	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

NEDD4_HUMAN
NC score	0.125325 (rank : 15)	θ value	0.0252991 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	214	Shared Neighborhood Hits	27
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_HUMAN
NC score	0.121828 (rank : 16)	θ value	0.0193708 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	238	Shared Neighborhood Hits	27
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
NC score	0.120988 (rank : 17)	θ value	0.125558 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	212	Shared Neighborhood Hits	27
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NED4L_MOUSE
NC score	0.120378 (rank : 18)	θ value	0.0193708 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SMUF2_HUMAN
NC score	0.116322 (rank : 19)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

ITCH_MOUSE
NC score	0.115648 (rank : 20)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	127	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
NC score	0.112418 (rank : 21)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	162	Shared Neighborhood Hits	25
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

GAS7_HUMAN
NC score	0.101002 (rank : 22)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SAV1_HUMAN
NC score	0.092917 (rank : 23)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	51	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.086904 (rank : 24)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	48	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

GAS7_MOUSE
NC score	0.086854 (rank : 25)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	259	Shared Neighborhood Hits	23
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SMUF1_MOUSE
NC score	0.086113 (rank : 26)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	36	Target Neighborhood Hits	142	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

YAP1_MOUSE
NC score	0.082548 (rank : 27)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	36	Target Neighborhood Hits	96	Shared Neighborhood Hits	23
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SMUF1_HUMAN
NC score	0.077074 (rank : 28)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	36	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

PQBP1_MOUSE
NC score	0.075358 (rank : 29)	θ value	0.21417 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	Q91VJ5, Q80WW2, Q9ER43, Q9QYY2	Gene names	Pqbp1, Npw38
Domain Architecture	No domain graphic available
Description	Polyglutamine-binding protein 1 (Polyglutamine tract-binding protein 1) (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38).

YAP1_HUMAN
NC score	0.071723 (rank : 30)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	36	Target Neighborhood Hits	173	Shared Neighborhood Hits	23
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

HUWE1_MOUSE
NC score	0.069899 (rank : 31)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	406	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

MAGI1_HUMAN
NC score	0.067860 (rank : 32)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	388	Shared Neighborhood Hits	22
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.067395 (rank : 33)	θ value	0.365318 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	403	Shared Neighborhood Hits	22
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PQBP1_HUMAN
NC score	0.066740 (rank : 34)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	O60828, Q4VY25, Q4VY26, Q4VY27, Q4VY29, Q4VY30, Q4VY34, Q4VY35, Q4VY36, Q4VY37, Q4VY38, Q9GZP2, Q9GZU4, Q9GZZ4	Gene names	PQBP1, NPW38
Domain Architecture	No domain graphic available
Description	Polyglutamine-binding protein 1 (Polyglutamine tract-binding protein 1) (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38).

K0317_HUMAN
NC score	0.064850 (rank : 35)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.064812 (rank : 36)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	36	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HUWE1_HUMAN
NC score	0.061788 (rank : 37)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	443	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HECD2_MOUSE
NC score	0.060880 (rank : 38)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.060601 (rank : 39)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3A_HUMAN
NC score	0.059487 (rank : 40)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	36	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3C_HUMAN
NC score	0.058967 (rank : 41)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	36	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.058838 (rank : 42)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	36	Target Neighborhood Hits	48	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_MOUSE
NC score	0.058831 (rank : 43)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	36	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

TRIPC_HUMAN
NC score	0.054090 (rank : 44)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	36	Target Neighborhood Hits	319	Shared Neighborhood Hits	12
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC5_HUMAN
NC score	0.051151 (rank : 45)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

WWTR1_HUMAN
NC score	0.051001 (rank : 46)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	36	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWC1_HUMAN
NC score	0.050727 (rank : 47)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	36	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

JIP1_HUMAN
NC score	0.050439 (rank : 48)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

WWC1_MOUSE
NC score	0.050136 (rank : 49)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	36	Target Neighborhood Hits	290	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

CJ030_HUMAN
NC score	0.029189 (rank : 50)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N7W2, Q5SYY7, Q5SYY8, Q5SYY9, Q8N5T7	Gene names	C10orf30
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf30.

STS_MOUSE
NC score	0.021465 (rank : 51)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

OSBL5_HUMAN
NC score	0.013324 (rank : 52)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	117	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

FA84B_HUMAN
NC score	0.011393 (rank : 53)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q96KN1	Gene names	FAM84B, NSE2
Domain Architecture	No domain graphic available
Description	Protein FAM84B (Protein NSE2) (Breast cancer membrane protein 101).

SMO_MOUSE
NC score	0.009396 (rank : 54)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

IKKE_HUMAN
NC score	0.001320 (rank : 55)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	837	Shared Neighborhood Hits	3
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

ZN692_HUMAN
NC score	-0.001172 (rank : 56)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	808	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BU19, Q5SRA5, Q5SRA6, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97	Gene names	ZNF692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.