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Network neighborhood for query Sequence : APBB1_HUMAN

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APBB1_HUMAN
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APBB1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	62	Target Neighborhood Hits	62	Shared Neighborhood Hits	62
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
θ value	0 (rank : 2)	NC score	0.994880 (rank : 2)
Query Neighborhood Hits	62	Target Neighborhood Hits	75	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB2_MOUSE
θ value	5.02443e-168 (rank : 3)	NC score	0.956712 (rank : 3)
Query Neighborhood Hits	62	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB2_HUMAN
θ value	8.86892e-165 (rank : 4)	NC score	0.952235 (rank : 4)
Query Neighborhood Hits	62	Target Neighborhood Hits	96	Shared Neighborhood Hits	27
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB3_HUMAN
θ value	2.01746e-92 (rank : 5)	NC score	0.940103 (rank : 6)
Query Neighborhood Hits	62	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
θ value	1.88829e-90 (rank : 6)	NC score	0.940233 (rank : 5)
Query Neighborhood Hits	62	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

SETD2_HUMAN
θ value	0.0148317 (rank : 7)	NC score	0.129483 (rank : 7)
Query Neighborhood Hits	62	Target Neighborhood Hits	412	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

YAP1_HUMAN
θ value	0.0330416 (rank : 8)	NC score	0.099189 (rank : 12)
Query Neighborhood Hits	62	Target Neighborhood Hits	173	Shared Neighborhood Hits	20
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

PSN2_HUMAN
θ value	0.0736092 (rank : 9)	NC score	0.077260 (rank : 28)
Query Neighborhood Hits	62	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

MEFV_HUMAN
θ value	0.0961366 (rank : 10)	NC score	0.015109 (rank : 56)
Query Neighborhood Hits	62	Target Neighborhood Hits	431	Shared Neighborhood Hits	3
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

WWP2_HUMAN
θ value	0.0961366 (rank : 11)	NC score	0.098262 (rank : 13)
Query Neighborhood Hits	62	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	0.0961366 (rank : 12)	NC score	0.110924 (rank : 10)
Query Neighborhood Hits	62	Target Neighborhood Hits	118	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

BCAS1_HUMAN
θ value	0.125558 (rank : 13)	NC score	0.079558 (rank : 25)
Query Neighborhood Hits	62	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

SMUF2_HUMAN
θ value	0.163984 (rank : 14)	NC score	0.085070 (rank : 18)
Query Neighborhood Hits	62	Target Neighborhood Hits	142	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

PSN2_MOUSE
θ value	0.279714 (rank : 15)	NC score	0.068050 (rank : 31)
Query Neighborhood Hits	62	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

WDR8_HUMAN
θ value	0.279714 (rank : 16)	NC score	0.036978 (rank : 43)
Query Neighborhood Hits	62	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2S5, Q5T0D6, Q9BUH7, Q9NTK7, Q9NX56	Gene names	WDR8
Domain Architecture
Description	WD repeat protein 8.

WWP1_HUMAN
θ value	0.279714 (rank : 17)	NC score	0.096631 (rank : 14)
Query Neighborhood Hits	62	Target Neighborhood Hits	262	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

RGS3_HUMAN
θ value	0.365318 (rank : 18)	NC score	0.017541 (rank : 50)
Query Neighborhood Hits	62	Target Neighborhood Hits	1375	Shared Neighborhood Hits	14
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

YAP1_MOUSE
θ value	0.365318 (rank : 19)	NC score	0.084609 (rank : 19)
Query Neighborhood Hits	62	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

CAPON_HUMAN
θ value	0.62314 (rank : 20)	NC score	0.093797 (rank : 15)
Query Neighborhood Hits	62	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

SMRC2_HUMAN
θ value	0.62314 (rank : 21)	NC score	0.040335 (rank : 41)
Query Neighborhood Hits	62	Target Neighborhood Hits	499	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

HUWE1_MOUSE
θ value	0.813845 (rank : 22)	NC score	0.051166 (rank : 40)
Query Neighborhood Hits	62	Target Neighborhood Hits	406	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

POGK_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.014049 (rank : 57)
Query Neighborhood Hits	62	Target Neighborhood Hits	263	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P215, Q8TE07	Gene names	POGK, KIAA1513
Domain Architecture
Description	Pogo transposable element with KRAB domain (LST003/SLTP003).

AL2SA_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.060481 (rank : 37)
Query Neighborhood Hits	62	Target Neighborhood Hits	97	Shared Neighborhood Hits	5
SwissProt Accessions	Q53TS8, Q8NCN6, Q96LN4	Gene names	ALS2CR11
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein.

CAPON_MOUSE
θ value	1.06291 (rank : 25)	NC score	0.085226 (rank : 17)
Query Neighborhood Hits	62	Target Neighborhood Hits	34	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

WWP1_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.090203 (rank : 16)
Query Neighborhood Hits	62	Target Neighborhood Hits	138	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

JIP1_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.082534 (rank : 21)
Query Neighborhood Hits	62	Target Neighborhood Hits	271	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

KR104_HUMAN
θ value	1.38821 (rank : 28)	NC score	0.015347 (rank : 54)
Query Neighborhood Hits	62	Target Neighborhood Hits	313	Shared Neighborhood Hits	4
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

PIN1_MOUSE
θ value	1.38821 (rank : 29)	NC score	0.126350 (rank : 8)
Query Neighborhood Hits	62	Target Neighborhood Hits	60	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

SMRC2_MOUSE
θ value	1.38821 (rank : 30)	NC score	0.037204 (rank : 42)
Query Neighborhood Hits	62	Target Neighborhood Hits	487	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

K0586_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.021139 (rank : 49)
Query Neighborhood Hits	62	Target Neighborhood Hits	311	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

MINT_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.013917 (rank : 58)
Query Neighborhood Hits	62	Target Neighborhood Hits	1291	Shared Neighborhood Hits	18
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NUMB_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.065290 (rank : 33)
Query Neighborhood Hits	62	Target Neighborhood Hits	112	Shared Neighborhood Hits	15
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

NUMB_MOUSE
θ value	2.36792 (rank : 34)	NC score	0.065082 (rank : 34)
Query Neighborhood Hits	62	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

PVRL2_HUMAN
θ value	2.36792 (rank : 35)	NC score	0.024298 (rank : 48)
Query Neighborhood Hits	62	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

PVRL2_MOUSE
θ value	2.36792 (rank : 36)	NC score	0.025287 (rank : 47)
Query Neighborhood Hits	62	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

SPAG1_MOUSE
θ value	2.36792 (rank : 37)	NC score	0.017222 (rank : 51)
Query Neighborhood Hits	62	Target Neighborhood Hits	218	Shared Neighborhood Hits	4
SwissProt Accessions	Q80ZX8, Q8CCK7, Q9QZJ3, Q9QZJ4	Gene names	Spag1, Tpis
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS).

ZAR1_MOUSE
θ value	2.36792 (rank : 38)	NC score	0.028388 (rank : 45)
Query Neighborhood Hits	62	Target Neighborhood Hits	254	Shared Neighborhood Hits	6
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ANK1_HUMAN
θ value	3.0926 (rank : 39)	NC score	0.006525 (rank : 67)
Query Neighborhood Hits	62	Target Neighborhood Hits	416	Shared Neighborhood Hits	5
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

NEDD4_HUMAN
θ value	3.0926 (rank : 40)	NC score	0.082676 (rank : 20)
Query Neighborhood Hits	62	Target Neighborhood Hits	214	Shared Neighborhood Hits	23
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

SETX_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.017054 (rank : 52)
Query Neighborhood Hits	62	Target Neighborhood Hits	368	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

ARH_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.081166 (rank : 22)
Query Neighborhood Hits	62	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

ATS12_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.008838 (rank : 63)
Query Neighborhood Hits	62	Target Neighborhood Hits	251	Shared Neighborhood Hits	7
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

C8AP2_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.013894 (rank : 59)
Query Neighborhood Hits	62	Target Neighborhood Hits	405	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

JIP1_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.065771 (rank : 32)
Query Neighborhood Hits	62	Target Neighborhood Hits	259	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

WWTR1_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.061216 (rank : 36)
Query Neighborhood Hits	62	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

ZAR1_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.026465 (rank : 46)
Query Neighborhood Hits	62	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ARH_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.081047 (rank : 23)
Query Neighborhood Hits	62	Target Neighborhood Hits	38	Shared Neighborhood Hits	12
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

GPTC3_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.015148 (rank : 55)
Query Neighborhood Hits	62	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q96I76, Q5JYH2, Q8NDJ2, Q9H9Z3	Gene names	GPATC3
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 3.

NED4L_MOUSE
θ value	5.27518 (rank : 50)	NC score	0.078590 (rank : 27)
Query Neighborhood Hits	62	Target Neighborhood Hits	231	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.079130 (rank : 26)
Query Neighborhood Hits	62	Target Neighborhood Hits	212	Shared Neighborhood Hits	22
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

RGS3_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.016136 (rank : 53)
Query Neighborhood Hits	62	Target Neighborhood Hits	1621	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

UBP8_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.010057 (rank : 61)
Query Neighborhood Hits	62	Target Neighborhood Hits	751	Shared Neighborhood Hits	11
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

CMGA_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.034294 (rank : 44)
Query Neighborhood Hits	62	Target Neighborhood Hits	238	Shared Neighborhood Hits	6
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

NED4L_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.079783 (rank : 24)
Query Neighborhood Hits	62	Target Neighborhood Hits	238	Shared Neighborhood Hits	26
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

TARA_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.011573 (rank : 60)
Query Neighborhood Hits	62	Target Neighborhood Hits	1626	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ANK2_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.007426 (rank : 65)
Query Neighborhood Hits	62	Target Neighborhood Hits	1615	Shared Neighborhood Hits	18
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CAC1F_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.002884 (rank : 68)
Query Neighborhood Hits	62	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

DICER_MOUSE
θ value	8.99809 (rank : 59)	NC score	0.006762 (rank : 66)
Query Neighborhood Hits	62	Target Neighborhood Hits	140	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

FYB_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.009771 (rank : 62)
Query Neighborhood Hits	62	Target Neighborhood Hits	379	Shared Neighborhood Hits	7
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

PINL_HUMAN
θ value	8.99809 (rank : 61)	NC score	0.115268 (rank : 9)
Query Neighborhood Hits	62	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

UBP8_MOUSE
θ value	8.99809 (rank : 62)	NC score	0.008593 (rank : 64)
Query Neighborhood Hits	62	Target Neighborhood Hits	362	Shared Neighborhood Hits	8
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

GAS7_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.064026 (rank : 35)
Query Neighborhood Hits	62	Target Neighborhood Hits	258	Shared Neighborhood Hits	20
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.051471 (rank : 39)
Query Neighborhood Hits	62	Target Neighborhood Hits	259	Shared Neighborhood Hits	20
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

ITCH_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.072655 (rank : 30)
Query Neighborhood Hits	62	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.075872 (rank : 29)
Query Neighborhood Hits	62	Target Neighborhood Hits	127	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

PIN1_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.101438 (rank : 11)
Query Neighborhood Hits	62	Target Neighborhood Hits	59	Shared Neighborhood Hits	20
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.055746 (rank : 38)
Query Neighborhood Hits	62	Target Neighborhood Hits	142	Shared Neighborhood Hits	17
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

Hits sorted by NC score

APBB1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	62	Target Neighborhood Hits	62	Shared Neighborhood Hits	62
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.994880 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	62	Target Neighborhood Hits	75	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB2_MOUSE
NC score	0.956712 (rank : 3)	θ value	5.02443e-168 (rank : 3)
Query Neighborhood Hits	62	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB2_HUMAN
NC score	0.952235 (rank : 4)	θ value	8.86892e-165 (rank : 4)
Query Neighborhood Hits	62	Target Neighborhood Hits	96	Shared Neighborhood Hits	27
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB3_MOUSE
NC score	0.940233 (rank : 5)	θ value	1.88829e-90 (rank : 6)
Query Neighborhood Hits	62	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

APBB3_HUMAN
NC score	0.940103 (rank : 6)	θ value	2.01746e-92 (rank : 5)
Query Neighborhood Hits	62	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

SETD2_HUMAN
NC score	0.129483 (rank : 7)	θ value	0.0148317 (rank : 7)
Query Neighborhood Hits	62	Target Neighborhood Hits	412	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

PIN1_MOUSE
NC score	0.126350 (rank : 8)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	62	Target Neighborhood Hits	60	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PINL_HUMAN
NC score	0.115268 (rank : 9)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	62	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWP2_MOUSE
NC score	0.110924 (rank : 10)	θ value	0.0961366 (rank : 12)
Query Neighborhood Hits	62	Target Neighborhood Hits	118	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

PIN1_HUMAN
NC score	0.101438 (rank : 11)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	62	Target Neighborhood Hits	59	Shared Neighborhood Hits	20
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

YAP1_HUMAN
NC score	0.099189 (rank : 12)	θ value	0.0330416 (rank : 8)
Query Neighborhood Hits	62	Target Neighborhood Hits	173	Shared Neighborhood Hits	20
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

WWP2_HUMAN
NC score	0.098262 (rank : 13)	θ value	0.0961366 (rank : 11)
Query Neighborhood Hits	62	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_HUMAN
NC score	0.096631 (rank : 14)	θ value	0.279714 (rank : 17)
Query Neighborhood Hits	62	Target Neighborhood Hits	262	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

CAPON_HUMAN
NC score	0.093797 (rank : 15)	θ value	0.62314 (rank : 20)
Query Neighborhood Hits	62	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

WWP1_MOUSE
NC score	0.090203 (rank : 16)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	62	Target Neighborhood Hits	138	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

CAPON_MOUSE
NC score	0.085226 (rank : 17)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	62	Target Neighborhood Hits	34	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

SMUF2_HUMAN
NC score	0.085070 (rank : 18)	θ value	0.163984 (rank : 14)
Query Neighborhood Hits	62	Target Neighborhood Hits	142	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

YAP1_MOUSE
NC score	0.084609 (rank : 19)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	62	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

NEDD4_HUMAN
NC score	0.082676 (rank : 20)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	62	Target Neighborhood Hits	214	Shared Neighborhood Hits	23
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

JIP1_HUMAN
NC score	0.082534 (rank : 21)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	62	Target Neighborhood Hits	271	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ARH_MOUSE
NC score	0.081166 (rank : 22)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	62	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

ARH_HUMAN
NC score	0.081047 (rank : 23)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	62	Target Neighborhood Hits	38	Shared Neighborhood Hits	12
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

NED4L_HUMAN
NC score	0.079783 (rank : 24)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	62	Target Neighborhood Hits	238	Shared Neighborhood Hits	26
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

BCAS1_HUMAN
NC score	0.079558 (rank : 25)	θ value	0.125558 (rank : 13)
Query Neighborhood Hits	62	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

NEDD4_MOUSE
NC score	0.079130 (rank : 26)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	62	Target Neighborhood Hits	212	Shared Neighborhood Hits	22
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NED4L_MOUSE
NC score	0.078590 (rank : 27)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	62	Target Neighborhood Hits	231	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PSN2_HUMAN
NC score	0.077260 (rank : 28)	θ value	0.0736092 (rank : 9)
Query Neighborhood Hits	62	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

ITCH_MOUSE
NC score	0.075872 (rank : 29)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	62	Target Neighborhood Hits	127	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
NC score	0.072655 (rank : 30)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	62	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

PSN2_MOUSE
NC score	0.068050 (rank : 31)	θ value	0.279714 (rank : 15)
Query Neighborhood Hits	62	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

JIP1_MOUSE
NC score	0.065771 (rank : 32)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	62	Target Neighborhood Hits	259	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NUMB_HUMAN
NC score	0.065290 (rank : 33)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	62	Target Neighborhood Hits	112	Shared Neighborhood Hits	15
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

NUMB_MOUSE
NC score	0.065082 (rank : 34)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	62	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

GAS7_HUMAN
NC score	0.064026 (rank : 35)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	62	Target Neighborhood Hits	258	Shared Neighborhood Hits	20
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

WWTR1_HUMAN
NC score	0.061216 (rank : 36)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	62	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

AL2SA_HUMAN
NC score	0.060481 (rank : 37)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	62	Target Neighborhood Hits	97	Shared Neighborhood Hits	5
SwissProt Accessions	Q53TS8, Q8NCN6, Q96LN4	Gene names	ALS2CR11
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein.

SMUF1_MOUSE
NC score	0.055746 (rank : 38)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	62	Target Neighborhood Hits	142	Shared Neighborhood Hits	17
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

GAS7_MOUSE
NC score	0.051471 (rank : 39)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	62	Target Neighborhood Hits	259	Shared Neighborhood Hits	20
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

HUWE1_MOUSE
NC score	0.051166 (rank : 40)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	62	Target Neighborhood Hits	406	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

SMRC2_HUMAN
NC score	0.040335 (rank : 41)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	62	Target Neighborhood Hits	499	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SMRC2_MOUSE
NC score	0.037204 (rank : 42)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	62	Target Neighborhood Hits	487	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

WDR8_HUMAN
NC score	0.036978 (rank : 43)	θ value	0.279714 (rank : 16)
Query Neighborhood Hits	62	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2S5, Q5T0D6, Q9BUH7, Q9NTK7, Q9NX56	Gene names	WDR8
Domain Architecture
Description	WD repeat protein 8.

CMGA_HUMAN
NC score	0.034294 (rank : 44)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	62	Target Neighborhood Hits	238	Shared Neighborhood Hits	6
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

ZAR1_MOUSE
NC score	0.028388 (rank : 45)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	62	Target Neighborhood Hits	254	Shared Neighborhood Hits	6
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ZAR1_HUMAN
NC score	0.026465 (rank : 46)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	62	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

PVRL2_MOUSE
NC score	0.025287 (rank : 47)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	62	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

PVRL2_HUMAN
NC score	0.024298 (rank : 48)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	62	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

K0586_HUMAN
NC score	0.021139 (rank : 49)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	62	Target Neighborhood Hits	311	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

RGS3_HUMAN
NC score	0.017541 (rank : 50)	θ value	0.365318 (rank : 18)
Query Neighborhood Hits	62	Target Neighborhood Hits	1375	Shared Neighborhood Hits	14
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SPAG1_MOUSE
NC score	0.017222 (rank : 51)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	62	Target Neighborhood Hits	218	Shared Neighborhood Hits	4
SwissProt Accessions	Q80ZX8, Q8CCK7, Q9QZJ3, Q9QZJ4	Gene names	Spag1, Tpis
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS).

SETX_HUMAN
NC score	0.017054 (rank : 52)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	62	Target Neighborhood Hits	368	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

RGS3_MOUSE
NC score	0.016136 (rank : 53)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	62	Target Neighborhood Hits	1621	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

KR104_HUMAN
NC score	0.015347 (rank : 54)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	62	Target Neighborhood Hits	313	Shared Neighborhood Hits	4
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

GPTC3_HUMAN
NC score	0.015148 (rank : 55)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	62	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q96I76, Q5JYH2, Q8NDJ2, Q9H9Z3	Gene names	GPATC3
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 3.

MEFV_HUMAN
NC score	0.015109 (rank : 56)	θ value	0.0961366 (rank : 10)
Query Neighborhood Hits	62	Target Neighborhood Hits	431	Shared Neighborhood Hits	3
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

POGK_HUMAN
NC score	0.014049 (rank : 57)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	62	Target Neighborhood Hits	263	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P215, Q8TE07	Gene names	POGK, KIAA1513
Domain Architecture
Description	Pogo transposable element with KRAB domain (LST003/SLTP003).

MINT_HUMAN
NC score	0.013917 (rank : 58)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	62	Target Neighborhood Hits	1291	Shared Neighborhood Hits	18
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

C8AP2_MOUSE
NC score	0.013894 (rank : 59)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	62	Target Neighborhood Hits	405	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

TARA_HUMAN
NC score	0.011573 (rank : 60)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	62	Target Neighborhood Hits	1626	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

UBP8_HUMAN
NC score	0.010057 (rank : 61)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	62	Target Neighborhood Hits	751	Shared Neighborhood Hits	11
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

FYB_HUMAN
NC score	0.009771 (rank : 62)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	62	Target Neighborhood Hits	379	Shared Neighborhood Hits	7
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

ATS12_HUMAN
NC score	0.008838 (rank : 63)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	62	Target Neighborhood Hits	251	Shared Neighborhood Hits	7
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

UBP8_MOUSE
NC score	0.008593 (rank : 64)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	62	Target Neighborhood Hits	362	Shared Neighborhood Hits	8
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

ANK2_HUMAN
NC score	0.007426 (rank : 65)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	62	Target Neighborhood Hits	1615	Shared Neighborhood Hits	18
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

DICER_MOUSE
NC score	0.006762 (rank : 66)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	62	Target Neighborhood Hits	140	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

ANK1_HUMAN
NC score	0.006525 (rank : 67)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	62	Target Neighborhood Hits	416	Shared Neighborhood Hits	5
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

CAC1F_HUMAN
NC score	0.002884 (rank : 68)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	62	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).