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Network neighborhood for query Sequence : CAC1F_HUMAN

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CAC1F_HUMAN
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CAC1A_HUMAN
θ value	0 (rank : 1)	NC score	0.947736 (rank : 13)
Query Neighborhood Hits	141	Target Neighborhood Hits	387	Shared Neighborhood Hits	76
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_MOUSE
θ value	0 (rank : 2)	NC score	0.955464 (rank : 11)
Query Neighborhood Hits	141	Target Neighborhood Hits	267	Shared Neighborhood Hits	66
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_HUMAN
θ value	0 (rank : 3)	NC score	0.956055 (rank : 10)
Query Neighborhood Hits	141	Target Neighborhood Hits	257	Shared Neighborhood Hits	60
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1B_MOUSE
θ value	0 (rank : 4)	NC score	0.951368 (rank : 12)
Query Neighborhood Hits	141	Target Neighborhood Hits	351	Shared Neighborhood Hits	66
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1C_HUMAN
θ value	0 (rank : 5)	NC score	0.991536 (rank : 7)
Query Neighborhood Hits	141	Target Neighborhood Hits	158	Shared Neighborhood Hits	61
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1C_MOUSE
θ value	0 (rank : 6)	NC score	0.991918 (rank : 6)
Query Neighborhood Hits	141	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1D_HUMAN
θ value	0 (rank : 7)	NC score	0.993397 (rank : 5)
Query Neighborhood Hits	141	Target Neighborhood Hits	118	Shared Neighborhood Hits	63
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1E_HUMAN
θ value	0 (rank : 8)	NC score	0.960135 (rank : 9)
Query Neighborhood Hits	141	Target Neighborhood Hits	148	Shared Neighborhood Hits	59
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	0 (rank : 9)	NC score	0.960243 (rank : 8)
Query Neighborhood Hits	141	Target Neighborhood Hits	167	Shared Neighborhood Hits	59
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1F_HUMAN
θ value	0 (rank : 10)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	141	Target Neighborhood Hits	141	Shared Neighborhood Hits	141
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_MOUSE
θ value	0 (rank : 11)	NC score	0.997447 (rank : 2)
Query Neighborhood Hits	141	Target Neighborhood Hits	142	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_HUMAN
θ value	0 (rank : 12)	NC score	0.993545 (rank : 3)
Query Neighborhood Hits	141	Target Neighborhood Hits	92	Shared Neighborhood Hits	59
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
θ value	0 (rank : 13)	NC score	0.993419 (rank : 4)
Query Neighborhood Hits	141	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

SC11A_HUMAN
θ value	6.7473e-72 (rank : 14)	NC score	0.858226 (rank : 18)
Query Neighborhood Hits	141	Target Neighborhood Hits	111	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN9A_HUMAN
θ value	4.83544e-70 (rank : 15)	NC score	0.840279 (rank : 25)
Query Neighborhood Hits	141	Target Neighborhood Hits	157	Shared Neighborhood Hits	61
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

CAC1I_HUMAN
θ value	6.31527e-70 (rank : 16)	NC score	0.896416 (rank : 14)
Query Neighborhood Hits	141	Target Neighborhood Hits	138	Shared Neighborhood Hits	63
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

SCN3A_HUMAN
θ value	1.83746e-69 (rank : 17)	NC score	0.843151 (rank : 23)
Query Neighborhood Hits	141	Target Neighborhood Hits	115	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN2A_HUMAN
θ value	3.13423e-69 (rank : 18)	NC score	0.840048 (rank : 26)
Query Neighborhood Hits	141	Target Neighborhood Hits	157	Shared Neighborhood Hits	59
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN4A_HUMAN
θ value	4.52582e-68 (rank : 19)	NC score	0.850337 (rank : 21)
Query Neighborhood Hits	141	Target Neighborhood Hits	133	Shared Neighborhood Hits	63
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SC11A_MOUSE
θ value	1.00825e-67 (rank : 20)	NC score	0.859965 (rank : 17)
Query Neighborhood Hits	141	Target Neighborhood Hits	116	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN8A_HUMAN
θ value	6.53529e-67 (rank : 21)	NC score	0.839791 (rank : 27)
Query Neighborhood Hits	141	Target Neighborhood Hits	135	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	3.24342e-66 (rank : 22)	NC score	0.837100 (rank : 29)
Query Neighborhood Hits	141	Target Neighborhood Hits	136	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1H_HUMAN
θ value	3.58603e-65 (rank : 23)	NC score	0.867686 (rank : 16)
Query Neighborhood Hits	141	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1H_MOUSE
θ value	3.58603e-65 (rank : 24)	NC score	0.870875 (rank : 15)
Query Neighborhood Hits	141	Target Neighborhood Hits	230	Shared Neighborhood Hits	65
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

SC10A_MOUSE
θ value	1.04338e-64 (rank : 25)	NC score	0.842081 (rank : 24)
Query Neighborhood Hits	141	Target Neighborhood Hits	107	Shared Neighborhood Hits	60
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN5A_HUMAN
θ value	6.76295e-64 (rank : 26)	NC score	0.852519 (rank : 20)
Query Neighborhood Hits	141	Target Neighborhood Hits	145	Shared Neighborhood Hits	62
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

CAC1G_HUMAN
θ value	1.15359e-63 (rank : 27)	NC score	0.852978 (rank : 19)
Query Neighborhood Hits	141	Target Neighborhood Hits	587	Shared Neighborhood Hits	70
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN1A_HUMAN
θ value	1.50663e-63 (rank : 28)	NC score	0.837717 (rank : 28)
Query Neighborhood Hits	141	Target Neighborhood Hits	148	Shared Neighborhood Hits	61
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SC10A_HUMAN
θ value	7.47731e-63 (rank : 29)	NC score	0.837087 (rank : 30)
Query Neighborhood Hits	141	Target Neighborhood Hits	116	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN7A_HUMAN
θ value	1.78386e-56 (rank : 30)	NC score	0.849894 (rank : 22)
Query Neighborhood Hits	141	Target Neighborhood Hits	135	Shared Neighborhood Hits	52
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

KCNF1_HUMAN
θ value	3.64472e-09 (rank : 31)	NC score	0.255439 (rank : 36)
Query Neighborhood Hits	141	Target Neighborhood Hits	109	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

PK2L2_HUMAN
θ value	3.64472e-09 (rank : 32)	NC score	0.392289 (rank : 31)
Query Neighborhood Hits	141	Target Neighborhood Hits	90	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_HUMAN
θ value	1.17247e-07 (rank : 33)	NC score	0.339065 (rank : 35)
Query Neighborhood Hits	141	Target Neighborhood Hits	105	Shared Neighborhood Hits	35
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PK2L2_MOUSE
θ value	5.81887e-07 (rank : 34)	NC score	0.355427 (rank : 33)
Query Neighborhood Hits	141	Target Neighborhood Hits	84	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
θ value	9.92553e-07 (rank : 35)	NC score	0.358209 (rank : 32)
Query Neighborhood Hits	141	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_MOUSE
θ value	9.92553e-07 (rank : 36)	NC score	0.344946 (rank : 34)
Query Neighborhood Hits	141	Target Neighborhood Hits	99	Shared Neighborhood Hits	37
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

KCNV2_HUMAN
θ value	0.000121331 (rank : 37)	NC score	0.240819 (rank : 37)
Query Neighborhood Hits	141	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCND3_HUMAN
θ value	0.00228821 (rank : 38)	NC score	0.191010 (rank : 44)
Query Neighborhood Hits	141	Target Neighborhood Hits	162	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.00228821 (rank : 39)	NC score	0.191135 (rank : 43)
Query Neighborhood Hits	141	Target Neighborhood Hits	162	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
θ value	0.00228821 (rank : 40)	NC score	0.187757 (rank : 45)
Query Neighborhood Hits	141	Target Neighborhood Hits	125	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCNS2_HUMAN
θ value	0.00509761 (rank : 41)	NC score	0.210964 (rank : 40)
Query Neighborhood Hits	141	Target Neighborhood Hits	129	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_MOUSE
θ value	0.00509761 (rank : 42)	NC score	0.214593 (rank : 39)
Query Neighborhood Hits	141	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCND2_HUMAN
θ value	0.00665767 (rank : 43)	NC score	0.184736 (rank : 47)
Query Neighborhood Hits	141	Target Neighborhood Hits	154	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.00665767 (rank : 44)	NC score	0.184874 (rank : 46)
Query Neighborhood Hits	141	Target Neighborhood Hits	156	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCNB1_HUMAN
θ value	0.0148317 (rank : 45)	NC score	0.207453 (rank : 41)
Query Neighborhood Hits	141	Target Neighborhood Hits	169	Shared Neighborhood Hits	58
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	0.0148317 (rank : 46)	NC score	0.207381 (rank : 42)
Query Neighborhood Hits	141	Target Neighborhood Hits	154	Shared Neighborhood Hits	57
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNB2_HUMAN
θ value	0.0148317 (rank : 47)	NC score	0.220106 (rank : 38)
Query Neighborhood Hits	141	Target Neighborhood Hits	212	Shared Neighborhood Hits	61
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNS1_MOUSE
θ value	0.0148317 (rank : 48)	NC score	0.150767 (rank : 51)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	50
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC4_HUMAN
θ value	0.0193708 (rank : 49)	NC score	0.141107 (rank : 54)
Query Neighborhood Hits	141	Target Neighborhood Hits	141	Shared Neighborhood Hits	52
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC3_HUMAN
θ value	0.0252991 (rank : 50)	NC score	0.130541 (rank : 56)
Query Neighborhood Hits	141	Target Neighborhood Hits	256	Shared Neighborhood Hits	54
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNS1_HUMAN
θ value	0.0252991 (rank : 51)	NC score	0.161656 (rank : 50)
Query Neighborhood Hits	141	Target Neighborhood Hits	116	Shared Neighborhood Hits	56
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

TIF1G_HUMAN
θ value	0.0252991 (rank : 52)	NC score	0.018203 (rank : 103)
Query Neighborhood Hits	141	Target Neighborhood Hits	410	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

KCNC3_MOUSE
θ value	0.0330416 (rank : 53)	NC score	0.128960 (rank : 58)
Query Neighborhood Hits	141	Target Neighborhood Hits	173	Shared Neighborhood Hits	51
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCND1_HUMAN
θ value	0.0431538 (rank : 54)	NC score	0.169855 (rank : 49)
Query Neighborhood Hits	141	Target Neighborhood Hits	160	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

BSN_MOUSE
θ value	0.0736092 (rank : 55)	NC score	0.028378 (rank : 92)
Query Neighborhood Hits	141	Target Neighborhood Hits	2057	Shared Neighborhood Hits	42
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

KCNG3_MOUSE
θ value	0.0736092 (rank : 56)	NC score	0.117896 (rank : 60)
Query Neighborhood Hits	141	Target Neighborhood Hits	91	Shared Neighborhood Hits	44
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

ACM5_HUMAN
θ value	0.125558 (rank : 57)	NC score	0.004814 (rank : 138)
Query Neighborhood Hits	141	Target Neighborhood Hits	878	Shared Neighborhood Hits	7
SwissProt Accessions	P08912, Q96RG7	Gene names	CHRM5
Domain Architecture
Description	Muscarinic acetylcholine receptor M5.

BSPRY_MOUSE
θ value	0.125558 (rank : 58)	NC score	0.018101 (rank : 104)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

KCND1_MOUSE
θ value	0.125558 (rank : 59)	NC score	0.173619 (rank : 48)
Query Neighborhood Hits	141	Target Neighborhood Hits	165	Shared Neighborhood Hits	56
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

ACM1_MOUSE
θ value	0.163984 (rank : 60)	NC score	0.004509 (rank : 140)
Query Neighborhood Hits	141	Target Neighborhood Hits	917	Shared Neighborhood Hits	7
SwissProt Accessions	P12657, Q8BJN3	Gene names	Chrm1, Chrm-1
Domain Architecture
Description	Muscarinic acetylcholine receptor M1.

KCNC4_MOUSE
θ value	0.163984 (rank : 61)	NC score	0.132833 (rank : 55)
Query Neighborhood Hits	141	Target Neighborhood Hits	130	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNG3_HUMAN
θ value	0.163984 (rank : 62)	NC score	0.119194 (rank : 59)
Query Neighborhood Hits	141	Target Neighborhood Hits	91	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

MAP1A_HUMAN
θ value	0.163984 (rank : 63)	NC score	0.013648 (rank : 112)
Query Neighborhood Hits	141	Target Neighborhood Hits	1626	Shared Neighborhood Hits	34
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

SFPQ_MOUSE
θ value	0.163984 (rank : 64)	NC score	0.022073 (rank : 96)
Query Neighborhood Hits	141	Target Neighborhood Hits	958	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

CSTFT_MOUSE
θ value	0.279714 (rank : 65)	NC score	0.016343 (rank : 107)
Query Neighborhood Hits	141	Target Neighborhood Hits	356	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

GCNL2_MOUSE
θ value	0.365318 (rank : 66)	NC score	0.018548 (rank : 102)
Query Neighborhood Hits	141	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JHD2	Gene names	Gcn5l2
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (mmGCN5).

KCNQ4_HUMAN
θ value	0.365318 (rank : 67)	NC score	0.094061 (rank : 62)
Query Neighborhood Hits	141	Target Neighborhood Hits	136	Shared Neighborhood Hits	40
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

MAP4_HUMAN
θ value	0.365318 (rank : 68)	NC score	0.021812 (rank : 97)
Query Neighborhood Hits	141	Target Neighborhood Hits	428	Shared Neighborhood Hits	11
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

DNL3_HUMAN
θ value	0.62314 (rank : 69)	NC score	0.036404 (rank : 90)
Query Neighborhood Hits	141	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

KCNC1_HUMAN
θ value	0.62314 (rank : 70)	NC score	0.145279 (rank : 52)
Query Neighborhood Hits	141	Target Neighborhood Hits	133	Shared Neighborhood Hits	53
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

TCAL5_HUMAN
θ value	0.62314 (rank : 71)	NC score	0.013903 (rank : 111)
Query Neighborhood Hits	141	Target Neighborhood Hits	806	Shared Neighborhood Hits	19
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

ACM1_HUMAN
θ value	0.813845 (rank : 72)	NC score	0.003958 (rank : 143)
Query Neighborhood Hits	141	Target Neighborhood Hits	908	Shared Neighborhood Hits	7
SwissProt Accessions	P11229	Gene names	CHRM1
Domain Architecture
Description	Muscarinic acetylcholine receptor M1.

ACTN2_HUMAN
θ value	0.813845 (rank : 73)	NC score	0.011867 (rank : 113)
Query Neighborhood Hits	141	Target Neighborhood Hits	295	Shared Neighborhood Hits	10
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

DNL3_MOUSE
θ value	0.813845 (rank : 74)	NC score	0.033468 (rank : 91)
Query Neighborhood Hits	141	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	P97386, P97385	Gene names	Lig3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

KCNC1_MOUSE
θ value	0.813845 (rank : 75)	NC score	0.143529 (rank : 53)
Query Neighborhood Hits	141	Target Neighborhood Hits	133	Shared Neighborhood Hits	53
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

MAP4_MOUSE
θ value	0.813845 (rank : 76)	NC score	0.023922 (rank : 94)
Query Neighborhood Hits	141	Target Neighborhood Hits	409	Shared Neighborhood Hits	18
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MDN1_HUMAN
θ value	0.813845 (rank : 77)	NC score	0.019266 (rank : 100)
Query Neighborhood Hits	141	Target Neighborhood Hits	662	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

NSBP1_MOUSE
θ value	0.813845 (rank : 78)	NC score	0.014608 (rank : 110)
Query Neighborhood Hits	141	Target Neighborhood Hits	681	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

VIPR2_MOUSE
θ value	0.813845 (rank : 79)	NC score	0.006620 (rank : 131)
Query Neighborhood Hits	141	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	P41588, P97750	Gene names	Vipr2
Domain Architecture
Description	Vasoactive intestinal polypeptide receptor 2 precursor (VIP-R-2) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3).

WNK1_MOUSE
θ value	0.813845 (rank : 80)	NC score	-0.002679 (rank : 162)
Query Neighborhood Hits	141	Target Neighborhood Hits	1179	Shared Neighborhood Hits	8
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

ZN219_HUMAN
θ value	0.813845 (rank : 81)	NC score	0.000842 (rank : 157)
Query Neighborhood Hits	141	Target Neighborhood Hits	876	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

DJBP_MOUSE
θ value	1.06291 (rank : 82)	NC score	0.056103 (rank : 88)
Query Neighborhood Hits	141	Target Neighborhood Hits	152	Shared Neighborhood Hits	18
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

SYTL1_MOUSE
θ value	1.06291 (rank : 83)	NC score	0.006358 (rank : 132)
Query Neighborhood Hits	141	Target Neighborhood Hits	314	Shared Neighborhood Hits	9
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

ACTN2_MOUSE
θ value	1.38821 (rank : 84)	NC score	0.010780 (rank : 118)
Query Neighborhood Hits	141	Target Neighborhood Hits	287	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

BASP_MOUSE
θ value	1.38821 (rank : 85)	NC score	0.021006 (rank : 98)
Query Neighborhood Hits	141	Target Neighborhood Hits	260	Shared Neighborhood Hits	12
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BSN_HUMAN
θ value	1.81305 (rank : 86)	NC score	0.023749 (rank : 95)
Query Neighborhood Hits	141	Target Neighborhood Hits	1537	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CO3A1_HUMAN
θ value	1.81305 (rank : 87)	NC score	0.009603 (rank : 120)
Query Neighborhood Hits	141	Target Neighborhood Hits	452	Shared Neighborhood Hits	14
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

JHD2B_MOUSE
θ value	1.81305 (rank : 88)	NC score	0.007413 (rank : 128)
Query Neighborhood Hits	141	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

KCNQ5_HUMAN
θ value	1.81305 (rank : 89)	NC score	0.070472 (rank : 79)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

MDC1_HUMAN
θ value	1.81305 (rank : 90)	NC score	0.005213 (rank : 137)
Query Neighborhood Hits	141	Target Neighborhood Hits	1446	Shared Neighborhood Hits	30
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NFAC3_HUMAN
θ value	1.81305 (rank : 91)	NC score	0.008203 (rank : 125)
Query Neighborhood Hits	141	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q12968, O75211, Q14516, Q99840, Q99841, Q99842	Gene names	NFATC3, NFAT4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

TPTE_HUMAN
θ value	1.81305 (rank : 92)	NC score	0.090812 (rank : 64)
Query Neighborhood Hits	141	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

BCR_HUMAN
θ value	2.36792 (rank : 93)	NC score	0.003252 (rank : 146)
Query Neighborhood Hits	141	Target Neighborhood Hits	204	Shared Neighborhood Hits	4
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

DCNL4_HUMAN
θ value	2.36792 (rank : 94)	NC score	0.009743 (rank : 119)
Query Neighborhood Hits	141	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q92564, Q7Z3F3, Q7Z6B8	Gene names	DCUN1D4, KIAA0276
Domain Architecture	No domain graphic available
Description	DCN1-like protein 4 (Defective in cullin neddylation protein 1-like protein 4) (DCUN1 domain-containing protein 4).

TAU_MOUSE
θ value	2.36792 (rank : 95)	NC score	0.018653 (rank : 101)
Query Neighborhood Hits	141	Target Neighborhood Hits	502	Shared Neighborhood Hits	17
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

XRCC1_MOUSE
θ value	2.36792 (rank : 96)	NC score	0.027177 (rank : 93)
Query Neighborhood Hits	141	Target Neighborhood Hits	242	Shared Neighborhood Hits	12
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

IF2P_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.009045 (rank : 121)
Query Neighborhood Hits	141	Target Neighborhood Hits	889	Shared Neighborhood Hits	17
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

WASIP_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.017531 (rank : 105)
Query Neighborhood Hits	141	Target Neighborhood Hits	458	Shared Neighborhood Hits	14
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

ZN513_HUMAN
θ value	3.0926 (rank : 99)	NC score	-0.004214 (rank : 165)
Query Neighborhood Hits	141	Target Neighborhood Hits	709	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N8E2	Gene names	ZNF513
Domain Architecture	No domain graphic available
Description	Zinc finger protein 513.

CTND1_HUMAN
θ value	4.03905 (rank : 100)	NC score	0.003710 (rank : 145)
Query Neighborhood Hits	141	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

GGEE1_HUMAN
θ value	4.03905 (rank : 101)	NC score	0.008412 (rank : 124)
Query Neighborhood Hits	141	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q96GU1, Q8WWL9	Gene names	PAGE5, GAGEE1
Domain Architecture	No domain graphic available
Description	G antigen family E member 1 (Prostate-associated gene 5 protein) (PAGE-5).

SMCA4_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.006234 (rank : 134)
Query Neighborhood Hits	141	Target Neighborhood Hits	597	Shared Neighborhood Hits	13
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

ACTN3_HUMAN
θ value	5.27518 (rank : 103)	NC score	0.008902 (rank : 122)
Query Neighborhood Hits	141	Target Neighborhood Hits	272	Shared Neighborhood Hits	10
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN3_MOUSE
θ value	5.27518 (rank : 104)	NC score	0.008892 (rank : 123)
Query Neighborhood Hits	141	Target Neighborhood Hits	265	Shared Neighborhood Hits	10
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

FOXH1_MOUSE
θ value	5.27518 (rank : 105)	NC score	0.002110 (rank : 153)
Query Neighborhood Hits	141	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	O88621, Q9QZL5, Q9R241	Gene names	Foxh1, Fast1, Fast2
Domain Architecture
Description	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast- 1) (Forkhead activin signal transducer 2) (Fast-2).

GCNL2_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.010868 (rank : 116)
Query Neighborhood Hits	141	Target Neighborhood Hits	159	Shared Neighborhood Hits	10
SwissProt Accessions	Q92830, Q9UCW1	Gene names	GCN5L2, GCN5, HGCN5
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (hsGCN5) (STAF97).

LTBP2_MOUSE
θ value	5.27518 (rank : 107)	NC score	-0.000136 (rank : 160)
Query Neighborhood Hits	141	Target Neighborhood Hits	617	Shared Neighborhood Hits	9
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

NIN_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.000140 (rank : 159)
Query Neighborhood Hits	141	Target Neighborhood Hits	1416	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NPCL1_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.004810 (rank : 139)
Query Neighborhood Hits	141	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

SEC63_HUMAN
θ value	5.27518 (rank : 110)	NC score	0.005930 (rank : 135)
Query Neighborhood Hits	141	Target Neighborhood Hits	586	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

SEC63_MOUSE
θ value	5.27518 (rank : 111)	NC score	0.008153 (rank : 126)
Query Neighborhood Hits	141	Target Neighborhood Hits	601	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SPTA1_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.003077 (rank : 147)
Query Neighborhood Hits	141	Target Neighborhood Hits	748	Shared Neighborhood Hits	10
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TAF4_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.020817 (rank : 99)
Query Neighborhood Hits	141	Target Neighborhood Hits	687	Shared Neighborhood Hits	17
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TPTE2_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.129135 (rank : 57)
Query Neighborhood Hits	141	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

UBP43_MOUSE
θ value	5.27518 (rank : 115)	NC score	0.002511 (rank : 150)
Query Neighborhood Hits	141	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BUM9, Q8VDP5	Gene names	Usp43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

ZC313_HUMAN
θ value	5.27518 (rank : 116)	NC score	0.016039 (rank : 108)
Query Neighborhood Hits	141	Target Neighborhood Hits	772	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZDH18_HUMAN
θ value	5.27518 (rank : 117)	NC score	0.002510 (rank : 151)
Query Neighborhood Hits	141	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUE0, Q5JYH0, Q9H020	Gene names	ZDHHC18
Domain Architecture
Description	Palmitoyltransferase ZDHHC18 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 18) (DHHC-18).

CO3A1_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.006244 (rank : 133)
Query Neighborhood Hits	141	Target Neighborhood Hits	466	Shared Neighborhood Hits	12
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

DAB2_MOUSE
θ value	6.88961 (rank : 119)	NC score	0.004376 (rank : 141)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	6
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

DIPA_HUMAN
θ value	6.88961 (rank : 120)	NC score	0.015241 (rank : 109)
Query Neighborhood Hits	141	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q15834, Q96HA0	Gene names	CCDC85B, DIPA
Domain Architecture	No domain graphic available
Description	Delta-interacting protein A (Hepatitis delta antigen-interacting protein A) (Coiled-coil domain-containing protein 85B).

GLI3_MOUSE
θ value	6.88961 (rank : 121)	NC score	-0.004169 (rank : 164)
Query Neighborhood Hits	141	Target Neighborhood Hits	807	Shared Neighborhood Hits	7
SwissProt Accessions	Q61602	Gene names	Gli3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

HDAC5_MOUSE
θ value	6.88961 (rank : 122)	NC score	0.001755 (rank : 154)
Query Neighborhood Hits	141	Target Neighborhood Hits	310	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

KCNQ2_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.065541 (rank : 83)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	34
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

NET2_HUMAN
θ value	6.88961 (rank : 124)	NC score	0.000473 (rank : 158)
Query Neighborhood Hits	141	Target Neighborhood Hits	194	Shared Neighborhood Hits	2
SwissProt Accessions	O00634	Gene names	NTN2L
Domain Architecture	No domain graphic available
Description	Netrin-2-like protein precursor.

SFPQ_HUMAN
θ value	6.88961 (rank : 125)	NC score	0.017049 (rank : 106)
Query Neighborhood Hits	141	Target Neighborhood Hits	986	Shared Neighborhood Hits	17
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

ZN447_HUMAN
θ value	6.88961 (rank : 126)	NC score	-0.003236 (rank : 163)
Query Neighborhood Hits	141	Target Neighborhood Hits	899	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

ACM3_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.000916 (rank : 156)
Query Neighborhood Hits	141	Target Neighborhood Hits	931	Shared Neighborhood Hits	7
SwissProt Accessions	P20309, Q4QRI3, Q5VXY2, Q9HB60	Gene names	CHRM3
Domain Architecture
Description	Muscarinic acetylcholine receptor M3.

APBB1_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.002884 (rank : 149)
Query Neighborhood Hits	141	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

CSTFT_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.005776 (rank : 136)
Query Neighborhood Hits	141	Target Neighborhood Hits	292	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H0L4, O75174, Q53HK6, Q7LGE8, Q8N6T1	Gene names	CSTF2T, KIAA0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

DTNA_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.001615 (rank : 155)
Query Neighborhood Hits	141	Target Neighborhood Hits	295	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4J8, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500	Gene names	DTNA, DRP3
Domain Architecture
Description	Dystrobrevin alpha (Dystrobrevin-alpha) (Dystrophin-related protein 3).

IDD_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.002934 (rank : 148)
Query Neighborhood Hits	141	Target Neighborhood Hits	127	Shared Neighborhood Hits	3
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

ITF2_HUMAN
θ value	8.99809 (rank : 132)	NC score	0.004189 (rank : 142)
Query Neighborhood Hits	141	Target Neighborhood Hits	168	Shared Neighborhood Hits	6
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ITF2_MOUSE
θ value	8.99809 (rank : 133)	NC score	0.003901 (rank : 144)
Query Neighborhood Hits	141	Target Neighborhood Hits	154	Shared Neighborhood Hits	7
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

JPH1_MOUSE
θ value	8.99809 (rank : 134)	NC score	0.002345 (rank : 152)
Query Neighborhood Hits	141	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

PARP1_MOUSE
θ value	8.99809 (rank : 135)	NC score	0.006830 (rank : 130)
Query Neighborhood Hits	141	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	P11103, Q9JLX4, Q9QVQ3	Gene names	Parp1, Adprp, Adprt, Adprt1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) (msPARP).

SFR16_MOUSE
θ value	8.99809 (rank : 136)	NC score	0.010995 (rank : 115)
Query Neighborhood Hits	141	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

SNIP1_HUMAN
θ value	8.99809 (rank : 137)	NC score	0.010809 (rank : 117)
Query Neighborhood Hits	141	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TAD8, Q96SP9, Q9H9T7	Gene names	SNIP1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

SYNPO_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.006993 (rank : 129)
Query Neighborhood Hits	141	Target Neighborhood Hits	281	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

VASP_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.007635 (rank : 127)
Query Neighborhood Hits	141	Target Neighborhood Hits	201	Shared Neighborhood Hits	7
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

VSX1_MOUSE
θ value	8.99809 (rank : 140)	NC score	-0.001804 (rank : 161)
Query Neighborhood Hits	141	Target Neighborhood Hits	356	Shared Neighborhood Hits	2
SwissProt Accessions	Q91V10	Gene names	Vsx1, Rinx
Domain Architecture
Description	Visual system homeobox 1 (Transcription factor VSX1) (Retinal inner nuclear layer homeobox protein) (Homeodomain protein RINX).

ZAR1_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.011839 (rank : 114)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	8
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

KCNA1_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.089795 (rank : 65)
Query Neighborhood Hits	141	Target Neighborhood Hits	104	Shared Neighborhood Hits	40
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA1_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.091824 (rank : 63)
Query Neighborhood Hits	141	Target Neighborhood Hits	103	Shared Neighborhood Hits	41
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA2_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.087338 (rank : 68)
Query Neighborhood Hits	141	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA2_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.088323 (rank : 66)
Query Neighborhood Hits	141	Target Neighborhood Hits	102	Shared Neighborhood Hits	38
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA3_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.076768 (rank : 74)
Query Neighborhood Hits	141	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.075844 (rank : 76)
Query Neighborhood Hits	141	Target Neighborhood Hits	103	Shared Neighborhood Hits	34
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA4_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.066669 (rank : 82)
Query Neighborhood Hits	141	Target Neighborhood Hits	108	Shared Neighborhood Hits	29
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.067064 (rank : 81)
Query Neighborhood Hits	141	Target Neighborhood Hits	98	Shared Neighborhood Hits	30
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA5_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.073798 (rank : 77)
Query Neighborhood Hits	141	Target Neighborhood Hits	124	Shared Neighborhood Hits	33
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.078688 (rank : 73)
Query Neighborhood Hits	141	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA6_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.081435 (rank : 71)
Query Neighborhood Hits	141	Target Neighborhood Hits	100	Shared Neighborhood Hits	37
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA6_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.087756 (rank : 67)
Query Neighborhood Hits	141	Target Neighborhood Hits	106	Shared Neighborhood Hits	40
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG1_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.085412 (rank : 69)
Query Neighborhood Hits	141	Target Neighborhood Hits	103	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNG2_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.082549 (rank : 70)
Query Neighborhood Hits	141	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG4_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.076457 (rank : 75)
Query Neighborhood Hits	141	Target Neighborhood Hits	99	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.068665 (rank : 80)
Query Neighborhood Hits	141	Target Neighborhood Hits	99	Shared Neighborhood Hits	35
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ1_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.081209 (rank : 72)
Query Neighborhood Hits	141	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ2_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.061205 (rank : 85)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ3_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.059889 (rank : 86)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ3_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.058787 (rank : 87)
Query Neighborhood Hits	141	Target Neighborhood Hits	105	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

MCLN2_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.061309 (rank : 84)
Query Neighborhood Hits	141	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

PKDRE_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.100316 (rank : 61)
Query Neighborhood Hits	141	Target Neighborhood Hits	64	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.072182 (rank : 78)
Query Neighborhood Hits	141	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TRPV3_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.051274 (rank : 89)
Query Neighborhood Hits	141	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

Hits sorted by NC score

CAC1F_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 10)
Query Neighborhood Hits	141	Target Neighborhood Hits	141	Shared Neighborhood Hits	141
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_MOUSE
NC score	0.997447 (rank : 2)	θ value	0 (rank : 11)
Query Neighborhood Hits	141	Target Neighborhood Hits	142	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_HUMAN
NC score	0.993545 (rank : 3)	θ value	0 (rank : 12)
Query Neighborhood Hits	141	Target Neighborhood Hits	92	Shared Neighborhood Hits	59
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
NC score	0.993419 (rank : 4)	θ value	0 (rank : 13)
Query Neighborhood Hits	141	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
NC score	0.993397 (rank : 5)	θ value	0 (rank : 7)
Query Neighborhood Hits	141	Target Neighborhood Hits	118	Shared Neighborhood Hits	63
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1C_MOUSE
NC score	0.991918 (rank : 6)	θ value	0 (rank : 6)
Query Neighborhood Hits	141	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.991536 (rank : 7)	θ value	0 (rank : 5)
Query Neighborhood Hits	141	Target Neighborhood Hits	158	Shared Neighborhood Hits	61
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1E_MOUSE
NC score	0.960243 (rank : 8)	θ value	0 (rank : 9)
Query Neighborhood Hits	141	Target Neighborhood Hits	167	Shared Neighborhood Hits	59
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.960135 (rank : 9)	θ value	0 (rank : 8)
Query Neighborhood Hits	141	Target Neighborhood Hits	148	Shared Neighborhood Hits	59
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1B_HUMAN
NC score	0.956055 (rank : 10)	θ value	0 (rank : 3)
Query Neighborhood Hits	141	Target Neighborhood Hits	257	Shared Neighborhood Hits	60
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_MOUSE
NC score	0.955464 (rank : 11)	θ value	0 (rank : 2)
Query Neighborhood Hits	141	Target Neighborhood Hits	267	Shared Neighborhood Hits	66
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
NC score	0.951368 (rank : 12)	θ value	0 (rank : 4)
Query Neighborhood Hits	141	Target Neighborhood Hits	351	Shared Neighborhood Hits	66
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_HUMAN
NC score	0.947736 (rank : 13)	θ value	0 (rank : 1)
Query Neighborhood Hits	141	Target Neighborhood Hits	387	Shared Neighborhood Hits	76
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1I_HUMAN
NC score	0.896416 (rank : 14)	θ value	6.31527e-70 (rank : 16)
Query Neighborhood Hits	141	Target Neighborhood Hits	138	Shared Neighborhood Hits	63
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.870875 (rank : 15)	θ value	3.58603e-65 (rank : 24)
Query Neighborhood Hits	141	Target Neighborhood Hits	230	Shared Neighborhood Hits	65
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.867686 (rank : 16)	θ value	3.58603e-65 (rank : 23)
Query Neighborhood Hits	141	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

SC11A_MOUSE
NC score	0.859965 (rank : 17)	θ value	1.00825e-67 (rank : 20)
Query Neighborhood Hits	141	Target Neighborhood Hits	116	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC11A_HUMAN
NC score	0.858226 (rank : 18)	θ value	6.7473e-72 (rank : 14)
Query Neighborhood Hits	141	Target Neighborhood Hits	111	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

CAC1G_HUMAN
NC score	0.852978 (rank : 19)	θ value	1.15359e-63 (rank : 27)
Query Neighborhood Hits	141	Target Neighborhood Hits	587	Shared Neighborhood Hits	70
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN5A_HUMAN
NC score	0.852519 (rank : 20)	θ value	6.76295e-64 (rank : 26)
Query Neighborhood Hits	141	Target Neighborhood Hits	145	Shared Neighborhood Hits	62
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN4A_HUMAN
NC score	0.850337 (rank : 21)	θ value	4.52582e-68 (rank : 19)
Query Neighborhood Hits	141	Target Neighborhood Hits	133	Shared Neighborhood Hits	63
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN7A_HUMAN
NC score	0.849894 (rank : 22)	θ value	1.78386e-56 (rank : 30)
Query Neighborhood Hits	141	Target Neighborhood Hits	135	Shared Neighborhood Hits	52
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN3A_HUMAN
NC score	0.843151 (rank : 23)	θ value	1.83746e-69 (rank : 17)
Query Neighborhood Hits	141	Target Neighborhood Hits	115	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SC10A_MOUSE
NC score	0.842081 (rank : 24)	θ value	1.04338e-64 (rank : 25)
Query Neighborhood Hits	141	Target Neighborhood Hits	107	Shared Neighborhood Hits	60
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN9A_HUMAN
NC score	0.840279 (rank : 25)	θ value	4.83544e-70 (rank : 15)
Query Neighborhood Hits	141	Target Neighborhood Hits	157	Shared Neighborhood Hits	61
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN2A_HUMAN
NC score	0.840048 (rank : 26)	θ value	3.13423e-69 (rank : 18)
Query Neighborhood Hits	141	Target Neighborhood Hits	157	Shared Neighborhood Hits	59
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN8A_HUMAN
NC score	0.839791 (rank : 27)	θ value	6.53529e-67 (rank : 21)
Query Neighborhood Hits	141	Target Neighborhood Hits	135	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN1A_HUMAN
NC score	0.837717 (rank : 28)	θ value	1.50663e-63 (rank : 28)
Query Neighborhood Hits	141	Target Neighborhood Hits	148	Shared Neighborhood Hits	61
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN8A_MOUSE
NC score	0.837100 (rank : 29)	θ value	3.24342e-66 (rank : 22)
Query Neighborhood Hits	141	Target Neighborhood Hits	136	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SC10A_HUMAN
NC score	0.837087 (rank : 30)	θ value	7.47731e-63 (rank : 29)
Query Neighborhood Hits	141	Target Neighborhood Hits	116	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

PK2L2_HUMAN
NC score	0.392289 (rank : 31)	θ value	3.64472e-09 (rank : 32)
Query Neighborhood Hits	141	Target Neighborhood Hits	90	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.358209 (rank : 32)	θ value	9.92553e-07 (rank : 35)
Query Neighborhood Hits	141	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.355427 (rank : 33)	θ value	5.81887e-07 (rank : 34)
Query Neighborhood Hits	141	Target Neighborhood Hits	84	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_MOUSE
NC score	0.344946 (rank : 34)	θ value	9.92553e-07 (rank : 36)
Query Neighborhood Hits	141	Target Neighborhood Hits	99	Shared Neighborhood Hits	37
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
NC score	0.339065 (rank : 35)	θ value	1.17247e-07 (rank : 33)
Query Neighborhood Hits	141	Target Neighborhood Hits	105	Shared Neighborhood Hits	35
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNF1_HUMAN
NC score	0.255439 (rank : 36)	θ value	3.64472e-09 (rank : 31)
Query Neighborhood Hits	141	Target Neighborhood Hits	109	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNV2_HUMAN
NC score	0.240819 (rank : 37)	θ value	0.000121331 (rank : 37)
Query Neighborhood Hits	141	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNB2_HUMAN
NC score	0.220106 (rank : 38)	θ value	0.0148317 (rank : 47)
Query Neighborhood Hits	141	Target Neighborhood Hits	212	Shared Neighborhood Hits	61
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNS2_MOUSE
NC score	0.214593 (rank : 39)	θ value	0.00509761 (rank : 42)
Query Neighborhood Hits	141	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
NC score	0.210964 (rank : 40)	θ value	0.00509761 (rank : 41)
Query Neighborhood Hits	141	Target Neighborhood Hits	129	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_HUMAN
NC score	0.207453 (rank : 41)	θ value	0.0148317 (rank : 45)
Query Neighborhood Hits	141	Target Neighborhood Hits	169	Shared Neighborhood Hits	58
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
NC score	0.207381 (rank : 42)	θ value	0.0148317 (rank : 46)
Query Neighborhood Hits	141	Target Neighborhood Hits	154	Shared Neighborhood Hits	57
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCND3_MOUSE
NC score	0.191135 (rank : 43)	θ value	0.00228821 (rank : 39)
Query Neighborhood Hits	141	Target Neighborhood Hits	162	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.191010 (rank : 44)	θ value	0.00228821 (rank : 38)
Query Neighborhood Hits	141	Target Neighborhood Hits	162	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
NC score	0.187757 (rank : 45)	θ value	0.00228821 (rank : 40)
Query Neighborhood Hits	141	Target Neighborhood Hits	125	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND2_MOUSE
NC score	0.184874 (rank : 46)	θ value	0.00665767 (rank : 44)
Query Neighborhood Hits	141	Target Neighborhood Hits	156	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.184736 (rank : 47)	θ value	0.00665767 (rank : 43)
Query Neighborhood Hits	141	Target Neighborhood Hits	154	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.173619 (rank : 48)	θ value	0.125558 (rank : 59)
Query Neighborhood Hits	141	Target Neighborhood Hits	165	Shared Neighborhood Hits	56
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.169855 (rank : 49)	θ value	0.0431538 (rank : 54)
Query Neighborhood Hits	141	Target Neighborhood Hits	160	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNS1_HUMAN
NC score	0.161656 (rank : 50)	θ value	0.0252991 (rank : 51)
Query Neighborhood Hits	141	Target Neighborhood Hits	116	Shared Neighborhood Hits	56
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNS1_MOUSE
NC score	0.150767 (rank : 51)	θ value	0.0148317 (rank : 48)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	50
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC1_HUMAN
NC score	0.145279 (rank : 52)	θ value	0.62314 (rank : 70)
Query Neighborhood Hits	141	Target Neighborhood Hits	133	Shared Neighborhood Hits	53
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
NC score	0.143529 (rank : 53)	θ value	0.813845 (rank : 75)
Query Neighborhood Hits	141	Target Neighborhood Hits	133	Shared Neighborhood Hits	53
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC4_HUMAN
NC score	0.141107 (rank : 54)	θ value	0.0193708 (rank : 49)
Query Neighborhood Hits	141	Target Neighborhood Hits	141	Shared Neighborhood Hits	52
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
NC score	0.132833 (rank : 55)	θ value	0.163984 (rank : 61)
Query Neighborhood Hits	141	Target Neighborhood Hits	130	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNC3_HUMAN
NC score	0.130541 (rank : 56)	θ value	0.0252991 (rank : 50)
Query Neighborhood Hits	141	Target Neighborhood Hits	256	Shared Neighborhood Hits	54
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

TPTE2_HUMAN
NC score	0.129135 (rank : 57)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	141	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNC3_MOUSE
NC score	0.128960 (rank : 58)	θ value	0.0330416 (rank : 53)
Query Neighborhood Hits	141	Target Neighborhood Hits	173	Shared Neighborhood Hits	51
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNG3_HUMAN
NC score	0.119194 (rank : 59)	θ value	0.163984 (rank : 62)
Query Neighborhood Hits	141	Target Neighborhood Hits	91	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_MOUSE
NC score	0.117896 (rank : 60)	θ value	0.0736092 (rank : 56)
Query Neighborhood Hits	141	Target Neighborhood Hits	91	Shared Neighborhood Hits	44
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

PKDRE_HUMAN
NC score	0.100316 (rank : 61)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	141	Target Neighborhood Hits	64	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNQ4_HUMAN
NC score	0.094061 (rank : 62)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	141	Target Neighborhood Hits	136	Shared Neighborhood Hits	40
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNA1_MOUSE
NC score	0.091824 (rank : 63)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	141	Target Neighborhood Hits	103	Shared Neighborhood Hits	41
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

TPTE_HUMAN
NC score	0.090812 (rank : 64)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	141	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

KCNA1_HUMAN
NC score	0.089795 (rank : 65)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	141	Target Neighborhood Hits	104	Shared Neighborhood Hits	40
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA2_MOUSE
NC score	0.088323 (rank : 66)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	141	Target Neighborhood Hits	102	Shared Neighborhood Hits	38
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA6_MOUSE
NC score	0.087756 (rank : 67)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	141	Target Neighborhood Hits	106	Shared Neighborhood Hits	40
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNA2_HUMAN
NC score	0.087338 (rank : 68)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	141	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNG1_HUMAN
NC score	0.085412 (rank : 69)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	141	Target Neighborhood Hits	103	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNG2_HUMAN
NC score	0.082549 (rank : 70)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	141	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNA6_HUMAN
NC score	0.081435 (rank : 71)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	141	Target Neighborhood Hits	100	Shared Neighborhood Hits	37
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNQ1_MOUSE
NC score	0.081209 (rank : 72)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	141	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA5_MOUSE
NC score	0.078688 (rank : 73)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	141	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA3_HUMAN
NC score	0.076768 (rank : 74)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	141	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNG4_HUMAN
NC score	0.076457 (rank : 75)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	141	Target Neighborhood Hits	99	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNA3_MOUSE
NC score	0.075844 (rank : 76)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	141	Target Neighborhood Hits	103	Shared Neighborhood Hits	34
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA5_HUMAN
NC score	0.073798 (rank : 77)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	141	Target Neighborhood Hits	124	Shared Neighborhood Hits	33
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

PKDRE_MOUSE
NC score	0.072182 (rank : 78)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	141	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNQ5_HUMAN
NC score	0.070472 (rank : 79)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

KCNQ1_HUMAN
NC score	0.068665 (rank : 80)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	141	Target Neighborhood Hits	99	Shared Neighborhood Hits	35
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA4_MOUSE
NC score	0.067064 (rank : 81)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	141	Target Neighborhood Hits	98	Shared Neighborhood Hits	30
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA4_HUMAN
NC score	0.066669 (rank : 82)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	141	Target Neighborhood Hits	108	Shared Neighborhood Hits	29
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNQ2_HUMAN
NC score	0.065541 (rank : 83)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	34
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

MCLN2_MOUSE
NC score	0.061309 (rank : 84)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	141	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

KCNQ2_MOUSE
NC score	0.061205 (rank : 85)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ3_HUMAN
NC score	0.059889 (rank : 86)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	141	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ3_MOUSE
NC score	0.058787 (rank : 87)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	141	Target Neighborhood Hits	105	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

DJBP_MOUSE
NC score	0.056103 (rank : 88)	θ value	1.06291 (rank : 82)
Query Neighborhood Hits	141	Target Neighborhood Hits	152	Shared Neighborhood Hits	18
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

TRPV3_HUMAN
NC score	0.051274 (rank : 89)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	141	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

DNL3_HUMAN
NC score	0.036404 (rank : 90)	θ value	0.62314 (rank : 69)
Query Neighborhood Hits	141	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

DNL3_MOUSE
NC score	0.033468 (rank : 91)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	141	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	P97386, P97385	Gene names	Lig3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

BSN_MOUSE
NC score	0.028378 (rank : 92)	θ value	0.0736092 (rank : 55)
Query Neighborhood Hits	141	Target Neighborhood Hits	2057	Shared Neighborhood Hits	42
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

XRCC1_MOUSE
NC score	0.027177 (rank : 93)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	141	Target Neighborhood Hits	242	Shared Neighborhood Hits	12
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

MAP4_MOUSE
NC score	0.023922 (rank : 94)	θ value	0.813845 (rank : 76)
Query Neighborhood Hits	141	Target Neighborhood Hits	409	Shared Neighborhood Hits	18
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

BSN_HUMAN
NC score	0.023749 (rank : 95)	θ value	1.81305 (rank : 86)
Query Neighborhood Hits	141	Target Neighborhood Hits	1537	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

SFPQ_MOUSE
NC score	0.022073 (rank : 96)	θ value	0.163984 (rank : 64)
Query Neighborhood Hits	141	Target Neighborhood Hits	958	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

MAP4_HUMAN
NC score	0.021812 (rank : 97)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	141	Target Neighborhood Hits	428	Shared Neighborhood Hits	11
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

BASP_MOUSE
NC score	0.021006 (rank : 98)	θ value	1.38821 (rank : 85)
Query Neighborhood Hits	141	Target Neighborhood Hits	260	Shared Neighborhood Hits	12
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

TAF4_HUMAN
NC score	0.020817 (rank : 99)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	141	Target Neighborhood Hits	687	Shared Neighborhood Hits	17
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

MDN1_HUMAN
NC score	0.019266 (rank : 100)	θ value	0.813845 (rank : 77)
Query Neighborhood Hits	141	Target Neighborhood Hits	662	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

TAU_MOUSE
NC score	0.018653 (rank : 101)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	141	Target Neighborhood Hits	502	Shared Neighborhood Hits	17
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

GCNL2_MOUSE
NC score	0.018548 (rank : 102)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	141	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JHD2	Gene names	Gcn5l2
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (mmGCN5).

TIF1G_HUMAN
NC score	0.018203 (rank : 103)	θ value	0.0252991 (rank : 52)
Query Neighborhood Hits	141	Target Neighborhood Hits	410	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

BSPRY_MOUSE
NC score	0.018101 (rank : 104)	θ value	0.125558 (rank : 58)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

WASIP_HUMAN
NC score	0.017531 (rank : 105)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	141	Target Neighborhood Hits	458	Shared Neighborhood Hits	14
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

SFPQ_HUMAN
NC score	0.017049 (rank : 106)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	141	Target Neighborhood Hits	986	Shared Neighborhood Hits	17
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

CSTFT_MOUSE
NC score	0.016343 (rank : 107)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	141	Target Neighborhood Hits	356	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

ZC313_HUMAN
NC score	0.016039 (rank : 108)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	141	Target Neighborhood Hits	772	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

DIPA_HUMAN
NC score	0.015241 (rank : 109)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	141	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q15834, Q96HA0	Gene names	CCDC85B, DIPA
Domain Architecture	No domain graphic available
Description	Delta-interacting protein A (Hepatitis delta antigen-interacting protein A) (Coiled-coil domain-containing protein 85B).

NSBP1_MOUSE
NC score	0.014608 (rank : 110)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	141	Target Neighborhood Hits	681	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

TCAL5_HUMAN
NC score	0.013903 (rank : 111)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	141	Target Neighborhood Hits	806	Shared Neighborhood Hits	19
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

MAP1A_HUMAN
NC score	0.013648 (rank : 112)	θ value	0.163984 (rank : 63)
Query Neighborhood Hits	141	Target Neighborhood Hits	1626	Shared Neighborhood Hits	34
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

ACTN2_HUMAN
NC score	0.011867 (rank : 113)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	141	Target Neighborhood Hits	295	Shared Neighborhood Hits	10
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ZAR1_HUMAN
NC score	0.011839 (rank : 114)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	8
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

SFR16_MOUSE
NC score	0.010995 (rank : 115)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	141	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

GCNL2_HUMAN
NC score	0.010868 (rank : 116)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	141	Target Neighborhood Hits	159	Shared Neighborhood Hits	10
SwissProt Accessions	Q92830, Q9UCW1	Gene names	GCN5L2, GCN5, HGCN5
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (hsGCN5) (STAF97).

SNIP1_HUMAN
NC score	0.010809 (rank : 117)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	141	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TAD8, Q96SP9, Q9H9T7	Gene names	SNIP1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

ACTN2_MOUSE
NC score	0.010780 (rank : 118)	θ value	1.38821 (rank : 84)
Query Neighborhood Hits	141	Target Neighborhood Hits	287	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

DCNL4_HUMAN
NC score	0.009743 (rank : 119)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	141	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q92564, Q7Z3F3, Q7Z6B8	Gene names	DCUN1D4, KIAA0276
Domain Architecture	No domain graphic available
Description	DCN1-like protein 4 (Defective in cullin neddylation protein 1-like protein 4) (DCUN1 domain-containing protein 4).

CO3A1_HUMAN
NC score	0.009603 (rank : 120)	θ value	1.81305 (rank : 87)
Query Neighborhood Hits	141	Target Neighborhood Hits	452	Shared Neighborhood Hits	14
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

IF2P_HUMAN
NC score	0.009045 (rank : 121)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	141	Target Neighborhood Hits	889	Shared Neighborhood Hits	17
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

ACTN3_HUMAN
NC score	0.008902 (rank : 122)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	141	Target Neighborhood Hits	272	Shared Neighborhood Hits	10
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN3_MOUSE
NC score	0.008892 (rank : 123)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	141	Target Neighborhood Hits	265	Shared Neighborhood Hits	10
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

GGEE1_HUMAN
NC score	0.008412 (rank : 124)	θ value	4.03905 (rank : 101)
Query Neighborhood Hits	141	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q96GU1, Q8WWL9	Gene names	PAGE5, GAGEE1
Domain Architecture	No domain graphic available
Description	G antigen family E member 1 (Prostate-associated gene 5 protein) (PAGE-5).

NFAC3_HUMAN
NC score	0.008203 (rank : 125)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	141	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q12968, O75211, Q14516, Q99840, Q99841, Q99842	Gene names	NFATC3, NFAT4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

SEC63_MOUSE
NC score	0.008153 (rank : 126)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	141	Target Neighborhood Hits	601	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

VASP_HUMAN
NC score	0.007635 (rank : 127)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	141	Target Neighborhood Hits	201	Shared Neighborhood Hits	7
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

JHD2B_MOUSE
NC score	0.007413 (rank : 128)	θ value	1.81305 (rank : 88)
Query Neighborhood Hits	141	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

SYNPO_HUMAN
NC score	0.006993 (rank : 129)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	141	Target Neighborhood Hits	281	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

PARP1_MOUSE
NC score	0.006830 (rank : 130)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	141	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	P11103, Q9JLX4, Q9QVQ3	Gene names	Parp1, Adprp, Adprt, Adprt1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) (msPARP).

VIPR2_MOUSE
NC score	0.006620 (rank : 131)	θ value	0.813845 (rank : 79)
Query Neighborhood Hits	141	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	P41588, P97750	Gene names	Vipr2
Domain Architecture
Description	Vasoactive intestinal polypeptide receptor 2 precursor (VIP-R-2) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3).

SYTL1_MOUSE
NC score	0.006358 (rank : 132)	θ value	1.06291 (rank : 83)
Query Neighborhood Hits	141	Target Neighborhood Hits	314	Shared Neighborhood Hits	9
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

CO3A1_MOUSE
NC score	0.006244 (rank : 133)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	141	Target Neighborhood Hits	466	Shared Neighborhood Hits	12
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

SMCA4_HUMAN
NC score	0.006234 (rank : 134)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	141	Target Neighborhood Hits	597	Shared Neighborhood Hits	13
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

SEC63_HUMAN
NC score	0.005930 (rank : 135)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	141	Target Neighborhood Hits	586	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

CSTFT_HUMAN
NC score	0.005776 (rank : 136)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	141	Target Neighborhood Hits	292	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H0L4, O75174, Q53HK6, Q7LGE8, Q8N6T1	Gene names	CSTF2T, KIAA0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

MDC1_HUMAN
NC score	0.005213 (rank : 137)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	141	Target Neighborhood Hits	1446	Shared Neighborhood Hits	30
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

ACM5_HUMAN
NC score	0.004814 (rank : 138)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	141	Target Neighborhood Hits	878	Shared Neighborhood Hits	7
SwissProt Accessions	P08912, Q96RG7	Gene names	CHRM5
Domain Architecture
Description	Muscarinic acetylcholine receptor M5.

NPCL1_MOUSE
NC score	0.004810 (rank : 139)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	141	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

ACM1_MOUSE
NC score	0.004509 (rank : 140)	θ value	0.163984 (rank : 60)
Query Neighborhood Hits	141	Target Neighborhood Hits	917	Shared Neighborhood Hits	7
SwissProt Accessions	P12657, Q8BJN3	Gene names	Chrm1, Chrm-1
Domain Architecture
Description	Muscarinic acetylcholine receptor M1.

DAB2_MOUSE
NC score	0.004376 (rank : 141)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	141	Target Neighborhood Hits	163	Shared Neighborhood Hits	6
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

ITF2_HUMAN
NC score	0.004189 (rank : 142)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	141	Target Neighborhood Hits	168	Shared Neighborhood Hits	6
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ACM1_HUMAN
NC score	0.003958 (rank : 143)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	141	Target Neighborhood Hits	908	Shared Neighborhood Hits	7
SwissProt Accessions	P11229	Gene names	CHRM1
Domain Architecture
Description	Muscarinic acetylcholine receptor M1.

ITF2_MOUSE
NC score	0.003901 (rank : 144)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	141	Target Neighborhood Hits	154	Shared Neighborhood Hits	7
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

CTND1_HUMAN
NC score	0.003710 (rank : 145)	θ value	4.03905 (rank : 100)
Query Neighborhood Hits	141	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

BCR_HUMAN
NC score	0.003252 (rank : 146)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	141	Target Neighborhood Hits	204	Shared Neighborhood Hits	4
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SPTA1_HUMAN
NC score	0.003077 (rank : 147)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	141	Target Neighborhood Hits	748	Shared Neighborhood Hits	10
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

IDD_HUMAN
NC score	0.002934 (rank : 148)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	141	Target Neighborhood Hits	127	Shared Neighborhood Hits	3
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

APBB1_HUMAN
NC score	0.002884 (rank : 149)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	141	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

UBP43_MOUSE
NC score	0.002511 (rank : 150)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	141	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BUM9, Q8VDP5	Gene names	Usp43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

ZDH18_HUMAN
NC score	0.002510 (rank : 151)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	141	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUE0, Q5JYH0, Q9H020	Gene names	ZDHHC18
Domain Architecture
Description	Palmitoyltransferase ZDHHC18 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 18) (DHHC-18).

JPH1_MOUSE
NC score	0.002345 (rank : 152)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	141	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

FOXH1_MOUSE
NC score	0.002110 (rank : 153)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	141	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	O88621, Q9QZL5, Q9R241	Gene names	Foxh1, Fast1, Fast2
Domain Architecture
Description	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast- 1) (Forkhead activin signal transducer 2) (Fast-2).

HDAC5_MOUSE
NC score	0.001755 (rank : 154)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	141	Target Neighborhood Hits	310	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

DTNA_HUMAN
NC score	0.001615 (rank : 155)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	141	Target Neighborhood Hits	295	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4J8, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500	Gene names	DTNA, DRP3
Domain Architecture
Description	Dystrobrevin alpha (Dystrobrevin-alpha) (Dystrophin-related protein 3).

ACM3_HUMAN
NC score	0.000916 (rank : 156)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	141	Target Neighborhood Hits	931	Shared Neighborhood Hits	7
SwissProt Accessions	P20309, Q4QRI3, Q5VXY2, Q9HB60	Gene names	CHRM3
Domain Architecture
Description	Muscarinic acetylcholine receptor M3.

ZN219_HUMAN
NC score	0.000842 (rank : 157)	θ value	0.813845 (rank : 81)
Query Neighborhood Hits	141	Target Neighborhood Hits	876	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

NET2_HUMAN
NC score	0.000473 (rank : 158)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	141	Target Neighborhood Hits	194	Shared Neighborhood Hits	2
SwissProt Accessions	O00634	Gene names	NTN2L
Domain Architecture	No domain graphic available
Description	Netrin-2-like protein precursor.

NIN_HUMAN
NC score	0.000140 (rank : 159)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	141	Target Neighborhood Hits	1416	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

LTBP2_MOUSE
NC score	-0.000136 (rank : 160)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	141	Target Neighborhood Hits	617	Shared Neighborhood Hits	9
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

VSX1_MOUSE
NC score	-0.001804 (rank : 161)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	141	Target Neighborhood Hits	356	Shared Neighborhood Hits	2
SwissProt Accessions	Q91V10	Gene names	Vsx1, Rinx
Domain Architecture
Description	Visual system homeobox 1 (Transcription factor VSX1) (Retinal inner nuclear layer homeobox protein) (Homeodomain protein RINX).

WNK1_MOUSE
NC score	-0.002679 (rank : 162)	θ value	0.813845 (rank : 80)
Query Neighborhood Hits	141	Target Neighborhood Hits	1179	Shared Neighborhood Hits	8
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

ZN447_HUMAN
NC score	-0.003236 (rank : 163)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	141	Target Neighborhood Hits	899	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

GLI3_MOUSE
NC score	-0.004169 (rank : 164)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	141	Target Neighborhood Hits	807	Shared Neighborhood Hits	7
SwissProt Accessions	Q61602	Gene names	Gli3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

ZN513_HUMAN
NC score	-0.004214 (rank : 165)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	141	Target Neighborhood Hits	709	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N8E2	Gene names	ZNF513
Domain Architecture	No domain graphic available
Description	Zinc finger protein 513.