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Network neighborhood for query Sequence : SCN4A_HUMAN

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SCN4A_HUMAN
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SC10A_HUMAN
θ value	0 (rank : 1)	NC score	0.989580 (rank : 12)
Query Neighborhood Hits	133	Target Neighborhood Hits	116	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
θ value	0 (rank : 2)	NC score	0.989952 (rank : 10)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	75
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC11A_HUMAN
θ value	0 (rank : 3)	NC score	0.990432 (rank : 9)
Query Neighborhood Hits	133	Target Neighborhood Hits	111	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC11A_MOUSE
θ value	0 (rank : 4)	NC score	0.990556 (rank : 8)
Query Neighborhood Hits	133	Target Neighborhood Hits	116	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN1A_HUMAN
θ value	0 (rank : 5)	NC score	0.991367 (rank : 3)
Query Neighborhood Hits	133	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0 (rank : 6)	NC score	0.991131 (rank : 6)
Query Neighborhood Hits	133	Target Neighborhood Hits	157	Shared Neighborhood Hits	67
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
θ value	0 (rank : 7)	NC score	0.992907 (rank : 2)
Query Neighborhood Hits	133	Target Neighborhood Hits	115	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
θ value	0 (rank : 8)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	133
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
θ value	0 (rank : 9)	NC score	0.987745 (rank : 13)
Query Neighborhood Hits	133	Target Neighborhood Hits	145	Shared Neighborhood Hits	74
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN7A_HUMAN
θ value	0 (rank : 10)	NC score	0.989721 (rank : 11)
Query Neighborhood Hits	133	Target Neighborhood Hits	135	Shared Neighborhood Hits	66
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN8A_HUMAN
θ value	0 (rank : 11)	NC score	0.991349 (rank : 4)
Query Neighborhood Hits	133	Target Neighborhood Hits	135	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	0 (rank : 12)	NC score	0.991151 (rank : 5)
Query Neighborhood Hits	133	Target Neighborhood Hits	136	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN9A_HUMAN
θ value	0 (rank : 13)	NC score	0.990950 (rank : 7)
Query Neighborhood Hits	133	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

CAC1H_MOUSE
θ value	3.82246e-75 (rank : 14)	NC score	0.884121 (rank : 15)
Query Neighborhood Hits	133	Target Neighborhood Hits	230	Shared Neighborhood Hits	70
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1G_HUMAN
θ value	2.09745e-73 (rank : 15)	NC score	0.859332 (rank : 20)
Query Neighborhood Hits	133	Target Neighborhood Hits	587	Shared Neighborhood Hits	66
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1I_HUMAN
θ value	2.73936e-73 (rank : 16)	NC score	0.903197 (rank : 14)
Query Neighborhood Hits	133	Target Neighborhood Hits	138	Shared Neighborhood Hits	68
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_HUMAN
θ value	1.7756e-72 (rank : 17)	NC score	0.877043 (rank : 16)
Query Neighborhood Hits	133	Target Neighborhood Hits	307	Shared Neighborhood Hits	71
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1S_MOUSE
θ value	2.31901e-72 (rank : 18)	NC score	0.856406 (rank : 21)
Query Neighborhood Hits	133	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
θ value	5.1662e-72 (rank : 19)	NC score	0.856105 (rank : 22)
Query Neighborhood Hits	133	Target Neighborhood Hits	118	Shared Neighborhood Hits	66
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1A_MOUSE
θ value	7.45998e-71 (rank : 20)	NC score	0.861806 (rank : 19)
Query Neighborhood Hits	133	Target Neighborhood Hits	267	Shared Neighborhood Hits	73
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1E_HUMAN
θ value	4.83544e-70 (rank : 21)	NC score	0.865237 (rank : 18)
Query Neighborhood Hits	133	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	6.31527e-70 (rank : 22)	NC score	0.865661 (rank : 17)
Query Neighborhood Hits	133	Target Neighborhood Hits	167	Shared Neighborhood Hits	64
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1C_MOUSE
θ value	1.83746e-69 (rank : 23)	NC score	0.848654 (rank : 29)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1A_HUMAN
θ value	2.3998e-69 (rank : 24)	NC score	0.853709 (rank : 25)
Query Neighborhood Hits	133	Target Neighborhood Hits	387	Shared Neighborhood Hits	71
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1F_MOUSE
θ value	5.34618e-69 (rank : 25)	NC score	0.851080 (rank : 27)
Query Neighborhood Hits	133	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_HUMAN
θ value	1.19101e-68 (rank : 26)	NC score	0.855314 (rank : 24)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	61
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_MOUSE
θ value	2.03155e-68 (rank : 27)	NC score	0.852725 (rank : 26)
Query Neighborhood Hits	133	Target Neighborhood Hits	351	Shared Neighborhood Hits	66
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_HUMAN
θ value	4.52582e-68 (rank : 28)	NC score	0.850337 (rank : 28)
Query Neighborhood Hits	133	Target Neighborhood Hits	141	Shared Neighborhood Hits	63
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1B_HUMAN
θ value	1.2325e-65 (rank : 29)	NC score	0.855664 (rank : 23)
Query Neighborhood Hits	133	Target Neighborhood Hits	257	Shared Neighborhood Hits	63
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1C_HUMAN
θ value	1.77973e-64 (rank : 30)	NC score	0.844145 (rank : 30)
Query Neighborhood Hits	133	Target Neighborhood Hits	158	Shared Neighborhood Hits	61
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

KCNB2_HUMAN
θ value	5.44631e-05 (rank : 31)	NC score	0.248805 (rank : 38)
Query Neighborhood Hits	133	Target Neighborhood Hits	212	Shared Neighborhood Hits	71
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNF1_HUMAN
θ value	5.44631e-05 (rank : 32)	NC score	0.267715 (rank : 34)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNS2_MOUSE
θ value	0.000121331 (rank : 33)	NC score	0.243612 (rank : 39)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	71
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
θ value	0.000270298 (rank : 34)	NC score	0.238374 (rank : 40)
Query Neighborhood Hits	133	Target Neighborhood Hits	129	Shared Neighborhood Hits	70
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCND3_HUMAN
θ value	0.00102713 (rank : 35)	NC score	0.212625 (rank : 44)
Query Neighborhood Hits	133	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.00102713 (rank : 36)	NC score	0.212775 (rank : 43)
Query Neighborhood Hits	133	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
θ value	0.00298849 (rank : 37)	NC score	0.210356 (rank : 45)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND2_HUMAN
θ value	0.00509761 (rank : 38)	NC score	0.204914 (rank : 47)
Query Neighborhood Hits	133	Target Neighborhood Hits	154	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.00509761 (rank : 39)	NC score	0.205084 (rank : 46)
Query Neighborhood Hits	133	Target Neighborhood Hits	156	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCNV2_HUMAN
θ value	0.00665767 (rank : 40)	NC score	0.250777 (rank : 37)
Query Neighborhood Hits	133	Target Neighborhood Hits	137	Shared Neighborhood Hits	70
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNA2_MOUSE
θ value	0.0113563 (rank : 41)	NC score	0.124662 (rank : 63)
Query Neighborhood Hits	133	Target Neighborhood Hits	102	Shared Neighborhood Hits	51
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA6_MOUSE
θ value	0.0113563 (rank : 42)	NC score	0.121387 (rank : 65)
Query Neighborhood Hits	133	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

PK2L2_HUMAN
θ value	0.0113563 (rank : 43)	NC score	0.304462 (rank : 31)
Query Neighborhood Hits	133	Target Neighborhood Hits	90	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

KCNA2_HUMAN
θ value	0.0148317 (rank : 44)	NC score	0.123781 (rank : 64)
Query Neighborhood Hits	133	Target Neighborhood Hits	101	Shared Neighborhood Hits	50
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

PK2L2_MOUSE
θ value	0.0148317 (rank : 45)	NC score	0.268555 (rank : 33)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

CABP5_MOUSE
θ value	0.0193708 (rank : 46)	NC score	0.060578 (rank : 91)
Query Neighborhood Hits	133	Target Neighborhood Hits	207	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KCNB1_HUMAN
θ value	0.0193708 (rank : 47)	NC score	0.228577 (rank : 41)
Query Neighborhood Hits	133	Target Neighborhood Hits	169	Shared Neighborhood Hits	71
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	0.0193708 (rank : 48)	NC score	0.228568 (rank : 42)
Query Neighborhood Hits	133	Target Neighborhood Hits	154	Shared Neighborhood Hits	70
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

CABP5_HUMAN
θ value	0.0330416 (rank : 49)	NC score	0.044914 (rank : 96)
Query Neighborhood Hits	133	Target Neighborhood Hits	197	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KCND1_HUMAN
θ value	0.0330416 (rank : 50)	NC score	0.185005 (rank : 49)
Query Neighborhood Hits	133	Target Neighborhood Hits	160	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

PK2L1_HUMAN
θ value	0.0330416 (rank : 51)	NC score	0.281953 (rank : 32)
Query Neighborhood Hits	133	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

VPS72_HUMAN
θ value	0.0330416 (rank : 52)	NC score	0.038823 (rank : 97)
Query Neighborhood Hits	133	Target Neighborhood Hits	274	Shared Neighborhood Hits	6
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

KCNC1_HUMAN
θ value	0.0431538 (rank : 53)	NC score	0.178883 (rank : 50)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	67
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
θ value	0.0431538 (rank : 54)	NC score	0.176621 (rank : 51)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	67
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

VPS72_MOUSE
θ value	0.0431538 (rank : 55)	NC score	0.037450 (rank : 98)
Query Neighborhood Hits	133	Target Neighborhood Hits	286	Shared Neighborhood Hits	8
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

KCNA3_MOUSE
θ value	0.0563607 (rank : 56)	NC score	0.115387 (rank : 69)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	47
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNC4_HUMAN
θ value	0.0563607 (rank : 57)	NC score	0.161566 (rank : 53)
Query Neighborhood Hits	133	Target Neighborhood Hits	141	Shared Neighborhood Hits	65
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
θ value	0.0563607 (rank : 58)	NC score	0.154625 (rank : 55)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCND1_MOUSE
θ value	0.0563607 (rank : 59)	NC score	0.186466 (rank : 48)
Query Neighborhood Hits	133	Target Neighborhood Hits	165	Shared Neighborhood Hits	70
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

PKD2_HUMAN
θ value	0.0563607 (rank : 60)	NC score	0.260050 (rank : 36)
Query Neighborhood Hits	133	Target Neighborhood Hits	105	Shared Neighborhood Hits	45
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNA6_HUMAN
θ value	0.0961366 (rank : 61)	NC score	0.118458 (rank : 66)
Query Neighborhood Hits	133	Target Neighborhood Hits	100	Shared Neighborhood Hits	50
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

TPTE2_HUMAN
θ value	0.0961366 (rank : 62)	NC score	0.146215 (rank : 58)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNA3_HUMAN
θ value	0.125558 (rank : 63)	NC score	0.116050 (rank : 68)
Query Neighborhood Hits	133	Target Neighborhood Hits	101	Shared Neighborhood Hits	49
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA4_HUMAN
θ value	0.125558 (rank : 64)	NC score	0.101807 (rank : 75)
Query Neighborhood Hits	133	Target Neighborhood Hits	108	Shared Neighborhood Hits	42
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	0.125558 (rank : 65)	NC score	0.102354 (rank : 74)
Query Neighborhood Hits	133	Target Neighborhood Hits	98	Shared Neighborhood Hits	43
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

TPTE_HUMAN
θ value	0.125558 (rank : 66)	NC score	0.102837 (rank : 73)
Query Neighborhood Hits	133	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

TRPC1_HUMAN
θ value	0.125558 (rank : 67)	NC score	0.074151 (rank : 85)
Query Neighborhood Hits	133	Target Neighborhood Hits	91	Shared Neighborhood Hits	23
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	0.125558 (rank : 68)	NC score	0.074245 (rank : 84)
Query Neighborhood Hits	133	Target Neighborhood Hits	87	Shared Neighborhood Hits	23
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC4_MOUSE
θ value	0.163984 (rank : 69)	NC score	0.046130 (rank : 95)
Query Neighborhood Hits	133	Target Neighborhood Hits	141	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

KCNC3_HUMAN
θ value	0.21417 (rank : 70)	NC score	0.152776 (rank : 56)
Query Neighborhood Hits	133	Target Neighborhood Hits	256	Shared Neighborhood Hits	66
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

TRPC4_HUMAN
θ value	0.21417 (rank : 71)	NC score	0.046856 (rank : 94)
Query Neighborhood Hits	133	Target Neighborhood Hits	140	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

KCNA5_HUMAN
θ value	0.279714 (rank : 72)	NC score	0.111719 (rank : 71)
Query Neighborhood Hits	133	Target Neighborhood Hits	124	Shared Neighborhood Hits	46
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	0.279714 (rank : 73)	NC score	0.117089 (rank : 67)
Query Neighborhood Hits	133	Target Neighborhood Hits	119	Shared Neighborhood Hits	50
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNC3_MOUSE
θ value	0.279714 (rank : 74)	NC score	0.150766 (rank : 57)
Query Neighborhood Hits	133	Target Neighborhood Hits	173	Shared Neighborhood Hits	65
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNS1_HUMAN
θ value	0.279714 (rank : 75)	NC score	0.176531 (rank : 52)
Query Neighborhood Hits	133	Target Neighborhood Hits	116	Shared Neighborhood Hits	69
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNA1_HUMAN
θ value	0.365318 (rank : 76)	NC score	0.124850 (rank : 62)
Query Neighborhood Hits	133	Target Neighborhood Hits	104	Shared Neighborhood Hits	53
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA1_MOUSE
θ value	0.365318 (rank : 77)	NC score	0.126242 (rank : 61)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	54
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

MAGD1_MOUSE
θ value	0.62314 (rank : 78)	NC score	0.006512 (rank : 117)
Query Neighborhood Hits	133	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

KCNG4_HUMAN
θ value	0.813845 (rank : 79)	NC score	0.098378 (rank : 77)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

PEDF_MOUSE
θ value	0.813845 (rank : 80)	NC score	0.003739 (rank : 126)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	P97298, O70629, O88691	Gene names	Serpinf1, Pedf, Sdf3
Domain Architecture
Description	Pigment epithelium-derived factor precursor (PEDF) (Serpin-F1) (Stromal cell-derived factor 3) (SDF-3) (Caspin).

PKD2_MOUSE
θ value	0.813845 (rank : 81)	NC score	0.263813 (rank : 35)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	46
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

TGON2_HUMAN
θ value	0.813845 (rank : 82)	NC score	0.016970 (rank : 101)
Query Neighborhood Hits	133	Target Neighborhood Hits	1037	Shared Neighborhood Hits	19
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TRPV3_HUMAN
θ value	0.813845 (rank : 83)	NC score	0.090234 (rank : 80)
Query Neighborhood Hits	133	Target Neighborhood Hits	198	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

ZO1_MOUSE
θ value	0.813845 (rank : 84)	NC score	0.006585 (rank : 116)
Query Neighborhood Hits	133	Target Neighborhood Hits	453	Shared Neighborhood Hits	4
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

APBA1_HUMAN
θ value	1.06291 (rank : 85)	NC score	0.008501 (rank : 110)
Query Neighborhood Hits	133	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

NCOA2_HUMAN
θ value	1.06291 (rank : 86)	NC score	0.009065 (rank : 107)
Query Neighborhood Hits	133	Target Neighborhood Hits	281	Shared Neighborhood Hits	7
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

F10A1_HUMAN
θ value	1.38821 (rank : 87)	NC score	0.008851 (rank : 108)
Query Neighborhood Hits	133	Target Neighborhood Hits	312	Shared Neighborhood Hits	6
SwissProt Accessions	P50502, O14999	Gene names	ST13, FAM10A1, HIP, SNC6
Domain Architecture
Description	Hsc70-interacting protein (Hip) (Suppression of tumorigenicity protein 13) (Putative tumor suppressor ST13) (Protein FAM10A1) (Progesterone receptor-associated p48 protein) (NY-REN-33 antigen).

SFR17_HUMAN
θ value	1.38821 (rank : 88)	NC score	0.011567 (rank : 104)
Query Neighborhood Hits	133	Target Neighborhood Hits	325	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TF01, Q5T064, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8TF00, Q96K10, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3	Gene names	SRRP130, C6orf111
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 130 (Serine-arginine-rich- splicing regulatory protein 130) (SRrp130) (SR-rich protein) (SR- related protein).

SMBP2_MOUSE
θ value	1.38821 (rank : 89)	NC score	0.008658 (rank : 109)
Query Neighborhood Hits	133	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

KCNS1_MOUSE
θ value	1.81305 (rank : 90)	NC score	0.158510 (rank : 54)
Query Neighborhood Hits	133	Target Neighborhood Hits	114	Shared Neighborhood Hits	63
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

PKDRE_HUMAN
θ value	1.81305 (rank : 91)	NC score	0.113899 (rank : 70)
Query Neighborhood Hits	133	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
θ value	1.81305 (rank : 92)	NC score	0.087595 (rank : 81)
Query Neighborhood Hits	133	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TRM6_HUMAN
θ value	1.81305 (rank : 93)	NC score	0.012453 (rank : 103)
Query Neighborhood Hits	133	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJA5, Q76P92, Q9BQV5, Q9ULR7	Gene names	TRM6, KIAA1153
Domain Architecture	No domain graphic available
Description	tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6).

AAK1_HUMAN
θ value	2.36792 (rank : 94)	NC score	-0.003330 (rank : 137)
Query Neighborhood Hits	133	Target Neighborhood Hits	1077	Shared Neighborhood Hits	6
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

FLNB_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.007254 (rank : 113)
Query Neighborhood Hits	133	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

KCNG3_MOUSE
θ value	2.36792 (rank : 96)	NC score	0.129249 (rank : 59)
Query Neighborhood Hits	133	Target Neighborhood Hits	91	Shared Neighborhood Hits	57
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNQ2_HUMAN
θ value	2.36792 (rank : 97)	NC score	0.072249 (rank : 86)
Query Neighborhood Hits	133	Target Neighborhood Hits	114	Shared Neighborhood Hits	45
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

SPTN5_HUMAN
θ value	2.36792 (rank : 98)	NC score	0.002356 (rank : 129)
Query Neighborhood Hits	133	Target Neighborhood Hits	674	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

ARI1B_HUMAN
θ value	3.0926 (rank : 99)	NC score	0.009417 (rank : 105)
Query Neighborhood Hits	133	Target Neighborhood Hits	567	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

FLNB_MOUSE
θ value	3.0926 (rank : 100)	NC score	0.006339 (rank : 118)
Query Neighborhood Hits	133	Target Neighborhood Hits	126	Shared Neighborhood Hits	5
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

ITB3_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.001184 (rank : 133)
Query Neighborhood Hits	133	Target Neighborhood Hits	325	Shared Neighborhood Hits	2
SwissProt Accessions	P05106, O15495, Q13413, Q14648, Q16499	Gene names	ITGB3, GP3A
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

AKAP2_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.004583 (rank : 122)
Query Neighborhood Hits	133	Target Neighborhood Hits	507	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

NCOA2_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.007110 (rank : 114)
Query Neighborhood Hits	133	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NSBP1_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.007399 (rank : 112)
Query Neighborhood Hits	133	Target Neighborhood Hits	681	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

F10A5_HUMAN
θ value	5.27518 (rank : 105)	NC score	0.006828 (rank : 115)
Query Neighborhood Hits	133	Target Neighborhood Hits	277	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFI4	Gene names	FAM10A5
Domain Architecture	No domain graphic available
Description	Protein FAM10A5.

KCNG1_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.105158 (rank : 72)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNG3_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.128872 (rank : 60)
Query Neighborhood Hits	133	Target Neighborhood Hits	91	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

TNR6A_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.009303 (rank : 106)
Query Neighborhood Hits	133	Target Neighborhood Hits	343	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

TRPM2_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.016905 (rank : 102)
Query Neighborhood Hits	133	Target Neighborhood Hits	61	Shared Neighborhood Hits	18
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPV3_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.061599 (rank : 90)
Query Neighborhood Hits	133	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV4_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.056273 (rank : 93)
Query Neighborhood Hits	133	Target Neighborhood Hits	150	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	5.27518 (rank : 112)	NC score	0.057646 (rank : 92)
Query Neighborhood Hits	133	Target Neighborhood Hits	117	Shared Neighborhood Hits	29
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

ASPM_MOUSE
θ value	6.88961 (rank : 113)	NC score	0.004020 (rank : 124)
Query Neighborhood Hits	133	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CJ27, O88482, Q8BJI8, Q8BKT4	Gene names	Aspm, Calmbp1, Sha1
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein homolog (Calmodulin-binding protein 1) (Spindle and hydroxyurea checkpoint abnormal protein) (Calmodulin-binding protein Sha1).

FYCO1_HUMAN
θ value	6.88961 (rank : 114)	NC score	-0.003346 (rank : 138)
Query Neighborhood Hits	133	Target Neighborhood Hits	1149	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

HPS1_MOUSE
θ value	6.88961 (rank : 115)	NC score	0.005956 (rank : 119)
Query Neighborhood Hits	133	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	O08983, O35155, O35725, O35950	Gene names	Hps1, Ep, Hps
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 1 protein homolog.

PI2R_HUMAN
θ value	6.88961 (rank : 116)	NC score	0.003158 (rank : 127)
Query Neighborhood Hits	133	Target Neighborhood Hits	290	Shared Neighborhood Hits	3
SwissProt Accessions	P43119	Gene names	PTGIR, PRIPR
Domain Architecture
Description	Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) (Prostaglandin I2 receptor).

RRBP1_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.002000 (rank : 130)
Query Neighborhood Hits	133	Target Neighborhood Hits	1306	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

UBP28_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.004205 (rank : 123)
Query Neighborhood Hits	133	Target Neighborhood Hits	178	Shared Neighborhood Hits	5
SwissProt Accessions	Q5I043, Q6NZP3, Q6ZPP1, Q8BWI1	Gene names	Usp28, Kiaa1515
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

41_MOUSE
θ value	8.99809 (rank : 119)	NC score	0.000307 (rank : 135)
Query Neighborhood Hits	133	Target Neighborhood Hits	184	Shared Neighborhood Hits	4
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ABCF1_MOUSE
θ value	8.99809 (rank : 120)	NC score	0.001426 (rank : 132)
Query Neighborhood Hits	133	Target Neighborhood Hits	321	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P542, Q6NV71	Gene names	Abcf1
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 1.

CALB1_HUMAN
θ value	8.99809 (rank : 121)	NC score	0.005271 (rank : 120)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	7
SwissProt Accessions	P05937	Gene names	CALB1, CAB27
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K).

CALB1_MOUSE
θ value	8.99809 (rank : 122)	NC score	0.005166 (rank : 121)
Query Neighborhood Hits	133	Target Neighborhood Hits	129	Shared Neighborhood Hits	7
SwissProt Accessions	P12658, Q545N6	Gene names	Calb1
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K) (Spot 35 protein) (PCD-29).

CBP_MOUSE
θ value	8.99809 (rank : 123)	NC score	0.001631 (rank : 131)
Query Neighborhood Hits	133	Target Neighborhood Hits	1051	Shared Neighborhood Hits	13
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

GP124_MOUSE
θ value	8.99809 (rank : 124)	NC score	0.000615 (rank : 134)
Query Neighborhood Hits	133	Target Neighborhood Hits	423	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

IFT81_MOUSE
θ value	8.99809 (rank : 125)	NC score	-0.003178 (rank : 136)
Query Neighborhood Hits	133	Target Neighborhood Hits	959	Shared Neighborhood Hits	7
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

KCD12_MOUSE
θ value	8.99809 (rank : 126)	NC score	0.008328 (rank : 111)
Query Neighborhood Hits	133	Target Neighborhood Hits	66	Shared Neighborhood Hits	14
SwissProt Accessions	Q6WVG3	Gene names	Kctd12, Pfet1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain).

KCNQ2_MOUSE
θ value	8.99809 (rank : 127)	NC score	0.069001 (rank : 89)
Query Neighborhood Hits	133	Target Neighborhood Hits	163	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

NEK1_HUMAN
θ value	8.99809 (rank : 128)	NC score	-0.005882 (rank : 140)
Query Neighborhood Hits	133	Target Neighborhood Hits	1129	Shared Neighborhood Hits	4
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NOG1_MOUSE
θ value	8.99809 (rank : 129)	NC score	0.003994 (rank : 125)
Query Neighborhood Hits	133	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q99ME9, Q99K16, Q99P78, Q9CT02	Gene names	Gtpbp4, Crfg, Nog1
Domain Architecture
Description	Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB).

OSBP1_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.002472 (rank : 128)
Query Neighborhood Hits	133	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

RAI14_HUMAN
θ value	8.99809 (rank : 131)	NC score	-0.004718 (rank : 139)
Query Neighborhood Hits	133	Target Neighborhood Hits	1367	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

TRPV1_HUMAN
θ value	8.99809 (rank : 132)	NC score	0.037084 (rank : 99)
Query Neighborhood Hits	133	Target Neighborhood Hits	184	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	8.99809 (rank : 133)	NC score	0.025778 (rank : 100)
Query Neighborhood Hits	133	Target Neighborhood Hits	189	Shared Neighborhood Hits	19
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

KCNG2_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.096979 (rank : 78)
Query Neighborhood Hits	133	Target Neighborhood Hits	83	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNQ1_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.087535 (rank : 82)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	47
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ1_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.095695 (rank : 79)
Query Neighborhood Hits	133	Target Neighborhood Hits	175	Shared Neighborhood Hits	51
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ3_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.069703 (rank : 87)
Query Neighborhood Hits	133	Target Neighborhood Hits	114	Shared Neighborhood Hits	48
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ3_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.069090 (rank : 88)
Query Neighborhood Hits	133	Target Neighborhood Hits	105	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ4_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.100855 (rank : 76)
Query Neighborhood Hits	133	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNQ5_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.080353 (rank : 83)
Query Neighborhood Hits	133	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

Hits sorted by NC score

SCN4A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 8)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	133
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN3A_HUMAN
NC score	0.992907 (rank : 2)	θ value	0 (rank : 7)
Query Neighborhood Hits	133	Target Neighborhood Hits	115	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN1A_HUMAN
NC score	0.991367 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	133	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN8A_HUMAN
NC score	0.991349 (rank : 4)	θ value	0 (rank : 11)
Query Neighborhood Hits	133	Target Neighborhood Hits	135	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
NC score	0.991151 (rank : 5)	θ value	0 (rank : 12)
Query Neighborhood Hits	133	Target Neighborhood Hits	136	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN2A_HUMAN
NC score	0.991131 (rank : 6)	θ value	0 (rank : 6)
Query Neighborhood Hits	133	Target Neighborhood Hits	157	Shared Neighborhood Hits	67
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN9A_HUMAN
NC score	0.990950 (rank : 7)	θ value	0 (rank : 13)
Query Neighborhood Hits	133	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SC11A_MOUSE
NC score	0.990556 (rank : 8)	θ value	0 (rank : 4)
Query Neighborhood Hits	133	Target Neighborhood Hits	116	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC11A_HUMAN
NC score	0.990432 (rank : 9)	θ value	0 (rank : 3)
Query Neighborhood Hits	133	Target Neighborhood Hits	111	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC10A_MOUSE
NC score	0.989952 (rank : 10)	θ value	0 (rank : 2)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	75
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN7A_HUMAN
NC score	0.989721 (rank : 11)	θ value	0 (rank : 10)
Query Neighborhood Hits	133	Target Neighborhood Hits	135	Shared Neighborhood Hits	66
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SC10A_HUMAN
NC score	0.989580 (rank : 12)	θ value	0 (rank : 1)
Query Neighborhood Hits	133	Target Neighborhood Hits	116	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN5A_HUMAN
NC score	0.987745 (rank : 13)	θ value	0 (rank : 9)
Query Neighborhood Hits	133	Target Neighborhood Hits	145	Shared Neighborhood Hits	74
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

CAC1I_HUMAN
NC score	0.903197 (rank : 14)	θ value	2.73936e-73 (rank : 16)
Query Neighborhood Hits	133	Target Neighborhood Hits	138	Shared Neighborhood Hits	68
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.884121 (rank : 15)	θ value	3.82246e-75 (rank : 14)
Query Neighborhood Hits	133	Target Neighborhood Hits	230	Shared Neighborhood Hits	70
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.877043 (rank : 16)	θ value	1.7756e-72 (rank : 17)
Query Neighborhood Hits	133	Target Neighborhood Hits	307	Shared Neighborhood Hits	71
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1E_MOUSE
NC score	0.865661 (rank : 17)	θ value	6.31527e-70 (rank : 22)
Query Neighborhood Hits	133	Target Neighborhood Hits	167	Shared Neighborhood Hits	64
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.865237 (rank : 18)	θ value	4.83544e-70 (rank : 21)
Query Neighborhood Hits	133	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1A_MOUSE
NC score	0.861806 (rank : 19)	θ value	7.45998e-71 (rank : 20)
Query Neighborhood Hits	133	Target Neighborhood Hits	267	Shared Neighborhood Hits	73
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1G_HUMAN
NC score	0.859332 (rank : 20)	θ value	2.09745e-73 (rank : 15)
Query Neighborhood Hits	133	Target Neighborhood Hits	587	Shared Neighborhood Hits	66
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1S_MOUSE
NC score	0.856406 (rank : 21)	θ value	2.31901e-72 (rank : 18)
Query Neighborhood Hits	133	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
NC score	0.856105 (rank : 22)	θ value	5.1662e-72 (rank : 19)
Query Neighborhood Hits	133	Target Neighborhood Hits	118	Shared Neighborhood Hits	66
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1B_HUMAN
NC score	0.855664 (rank : 23)	θ value	1.2325e-65 (rank : 29)
Query Neighborhood Hits	133	Target Neighborhood Hits	257	Shared Neighborhood Hits	63
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_HUMAN
NC score	0.855314 (rank : 24)	θ value	1.19101e-68 (rank : 26)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	61
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1A_HUMAN
NC score	0.853709 (rank : 25)	θ value	2.3998e-69 (rank : 24)
Query Neighborhood Hits	133	Target Neighborhood Hits	387	Shared Neighborhood Hits	71
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
NC score	0.852725 (rank : 26)	θ value	2.03155e-68 (rank : 27)
Query Neighborhood Hits	133	Target Neighborhood Hits	351	Shared Neighborhood Hits	66
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_MOUSE
NC score	0.851080 (rank : 27)	θ value	5.34618e-69 (rank : 25)
Query Neighborhood Hits	133	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.850337 (rank : 28)	θ value	4.52582e-68 (rank : 28)
Query Neighborhood Hits	133	Target Neighborhood Hits	141	Shared Neighborhood Hits	63
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.848654 (rank : 29)	θ value	1.83746e-69 (rank : 23)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.844145 (rank : 30)	θ value	1.77973e-64 (rank : 30)
Query Neighborhood Hits	133	Target Neighborhood Hits	158	Shared Neighborhood Hits	61
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PK2L2_HUMAN
NC score	0.304462 (rank : 31)	θ value	0.0113563 (rank : 43)
Query Neighborhood Hits	133	Target Neighborhood Hits	90	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.281953 (rank : 32)	θ value	0.0330416 (rank : 51)
Query Neighborhood Hits	133	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.268555 (rank : 33)	θ value	0.0148317 (rank : 45)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

KCNF1_HUMAN
NC score	0.267715 (rank : 34)	θ value	5.44631e-05 (rank : 32)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

PKD2_MOUSE
NC score	0.263813 (rank : 35)	θ value	0.813845 (rank : 81)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	46
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
NC score	0.260050 (rank : 36)	θ value	0.0563607 (rank : 60)
Query Neighborhood Hits	133	Target Neighborhood Hits	105	Shared Neighborhood Hits	45
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNV2_HUMAN
NC score	0.250777 (rank : 37)	θ value	0.00665767 (rank : 40)
Query Neighborhood Hits	133	Target Neighborhood Hits	137	Shared Neighborhood Hits	70
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNB2_HUMAN
NC score	0.248805 (rank : 38)	θ value	5.44631e-05 (rank : 31)
Query Neighborhood Hits	133	Target Neighborhood Hits	212	Shared Neighborhood Hits	71
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNS2_MOUSE
NC score	0.243612 (rank : 39)	θ value	0.000121331 (rank : 33)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	71
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
NC score	0.238374 (rank : 40)	θ value	0.000270298 (rank : 34)
Query Neighborhood Hits	133	Target Neighborhood Hits	129	Shared Neighborhood Hits	70
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_HUMAN
NC score	0.228577 (rank : 41)	θ value	0.0193708 (rank : 47)
Query Neighborhood Hits	133	Target Neighborhood Hits	169	Shared Neighborhood Hits	71
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
NC score	0.228568 (rank : 42)	θ value	0.0193708 (rank : 48)
Query Neighborhood Hits	133	Target Neighborhood Hits	154	Shared Neighborhood Hits	70
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCND3_MOUSE
NC score	0.212775 (rank : 43)	θ value	0.00102713 (rank : 36)
Query Neighborhood Hits	133	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.212625 (rank : 44)	θ value	0.00102713 (rank : 35)
Query Neighborhood Hits	133	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
NC score	0.210356 (rank : 45)	θ value	0.00298849 (rank : 37)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND2_MOUSE
NC score	0.205084 (rank : 46)	θ value	0.00509761 (rank : 39)
Query Neighborhood Hits	133	Target Neighborhood Hits	156	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.204914 (rank : 47)	θ value	0.00509761 (rank : 38)
Query Neighborhood Hits	133	Target Neighborhood Hits	154	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.186466 (rank : 48)	θ value	0.0563607 (rank : 59)
Query Neighborhood Hits	133	Target Neighborhood Hits	165	Shared Neighborhood Hits	70
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.185005 (rank : 49)	θ value	0.0330416 (rank : 50)
Query Neighborhood Hits	133	Target Neighborhood Hits	160	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNC1_HUMAN
NC score	0.178883 (rank : 50)	θ value	0.0431538 (rank : 53)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	67
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
NC score	0.176621 (rank : 51)	θ value	0.0431538 (rank : 54)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	67
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNS1_HUMAN
NC score	0.176531 (rank : 52)	θ value	0.279714 (rank : 75)
Query Neighborhood Hits	133	Target Neighborhood Hits	116	Shared Neighborhood Hits	69
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC4_HUMAN
NC score	0.161566 (rank : 53)	θ value	0.0563607 (rank : 57)
Query Neighborhood Hits	133	Target Neighborhood Hits	141	Shared Neighborhood Hits	65
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNS1_MOUSE
NC score	0.158510 (rank : 54)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	133	Target Neighborhood Hits	114	Shared Neighborhood Hits	63
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC4_MOUSE
NC score	0.154625 (rank : 55)	θ value	0.0563607 (rank : 58)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNC3_HUMAN
NC score	0.152776 (rank : 56)	θ value	0.21417 (rank : 70)
Query Neighborhood Hits	133	Target Neighborhood Hits	256	Shared Neighborhood Hits	66
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
NC score	0.150766 (rank : 57)	θ value	0.279714 (rank : 74)
Query Neighborhood Hits	133	Target Neighborhood Hits	173	Shared Neighborhood Hits	65
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

TPTE2_HUMAN
NC score	0.146215 (rank : 58)	θ value	0.0961366 (rank : 62)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNG3_MOUSE
NC score	0.129249 (rank : 59)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	133	Target Neighborhood Hits	91	Shared Neighborhood Hits	57
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_HUMAN
NC score	0.128872 (rank : 60)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	133	Target Neighborhood Hits	91	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNA1_MOUSE
NC score	0.126242 (rank : 61)	θ value	0.365318 (rank : 77)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	54
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA1_HUMAN
NC score	0.124850 (rank : 62)	θ value	0.365318 (rank : 76)
Query Neighborhood Hits	133	Target Neighborhood Hits	104	Shared Neighborhood Hits	53
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA2_MOUSE
NC score	0.124662 (rank : 63)	θ value	0.0113563 (rank : 41)
Query Neighborhood Hits	133	Target Neighborhood Hits	102	Shared Neighborhood Hits	51
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA2_HUMAN
NC score	0.123781 (rank : 64)	θ value	0.0148317 (rank : 44)
Query Neighborhood Hits	133	Target Neighborhood Hits	101	Shared Neighborhood Hits	50
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA6_MOUSE
NC score	0.121387 (rank : 65)	θ value	0.0113563 (rank : 42)
Query Neighborhood Hits	133	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNA6_HUMAN
NC score	0.118458 (rank : 66)	θ value	0.0961366 (rank : 61)
Query Neighborhood Hits	133	Target Neighborhood Hits	100	Shared Neighborhood Hits	50
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA5_MOUSE
NC score	0.117089 (rank : 67)	θ value	0.279714 (rank : 73)
Query Neighborhood Hits	133	Target Neighborhood Hits	119	Shared Neighborhood Hits	50
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA3_HUMAN
NC score	0.116050 (rank : 68)	θ value	0.125558 (rank : 63)
Query Neighborhood Hits	133	Target Neighborhood Hits	101	Shared Neighborhood Hits	49
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
NC score	0.115387 (rank : 69)	θ value	0.0563607 (rank : 56)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	47
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

PKDRE_HUMAN
NC score	0.113899 (rank : 70)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	133	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNA5_HUMAN
NC score	0.111719 (rank : 71)	θ value	0.279714 (rank : 72)
Query Neighborhood Hits	133	Target Neighborhood Hits	124	Shared Neighborhood Hits	46
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNG1_HUMAN
NC score	0.105158 (rank : 72)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

TPTE_HUMAN
NC score	0.102837 (rank : 73)	θ value	0.125558 (rank : 66)
Query Neighborhood Hits	133	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

KCNA4_MOUSE
NC score	0.102354 (rank : 74)	θ value	0.125558 (rank : 65)
Query Neighborhood Hits	133	Target Neighborhood Hits	98	Shared Neighborhood Hits	43
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA4_HUMAN
NC score	0.101807 (rank : 75)	θ value	0.125558 (rank : 64)
Query Neighborhood Hits	133	Target Neighborhood Hits	108	Shared Neighborhood Hits	42
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNQ4_HUMAN
NC score	0.100855 (rank : 76)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	133	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNG4_HUMAN
NC score	0.098378 (rank : 77)	θ value	0.813845 (rank : 79)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNG2_HUMAN
NC score	0.096979 (rank : 78)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	133	Target Neighborhood Hits	83	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNQ1_MOUSE
NC score	0.095695 (rank : 79)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	133	Target Neighborhood Hits	175	Shared Neighborhood Hits	51
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

TRPV3_HUMAN
NC score	0.090234 (rank : 80)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	133	Target Neighborhood Hits	198	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

PKDRE_MOUSE
NC score	0.087595 (rank : 81)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	133	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNQ1_HUMAN
NC score	0.087535 (rank : 82)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	47
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ5_HUMAN
NC score	0.080353 (rank : 83)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	133	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

TRPC1_MOUSE
NC score	0.074245 (rank : 84)	θ value	0.125558 (rank : 68)
Query Neighborhood Hits	133	Target Neighborhood Hits	87	Shared Neighborhood Hits	23
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.074151 (rank : 85)	θ value	0.125558 (rank : 67)
Query Neighborhood Hits	133	Target Neighborhood Hits	91	Shared Neighborhood Hits	23
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

KCNQ2_HUMAN
NC score	0.072249 (rank : 86)	θ value	2.36792 (rank : 97)
Query Neighborhood Hits	133	Target Neighborhood Hits	114	Shared Neighborhood Hits	45
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ3_HUMAN
NC score	0.069703 (rank : 87)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	133	Target Neighborhood Hits	114	Shared Neighborhood Hits	48
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ3_MOUSE
NC score	0.069090 (rank : 88)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	133	Target Neighborhood Hits	105	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ2_MOUSE
NC score	0.069001 (rank : 89)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	133	Target Neighborhood Hits	163	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

TRPV3_MOUSE
NC score	0.061599 (rank : 90)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	133	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

CABP5_MOUSE
NC score	0.060578 (rank : 91)	θ value	0.0193708 (rank : 46)
Query Neighborhood Hits	133	Target Neighborhood Hits	207	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

TRPV4_MOUSE
NC score	0.057646 (rank : 92)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	133	Target Neighborhood Hits	117	Shared Neighborhood Hits	29
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_HUMAN
NC score	0.056273 (rank : 93)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	133	Target Neighborhood Hits	150	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPC4_HUMAN
NC score	0.046856 (rank : 94)	θ value	0.21417 (rank : 71)
Query Neighborhood Hits	133	Target Neighborhood Hits	140	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.046130 (rank : 95)	θ value	0.163984 (rank : 69)
Query Neighborhood Hits	133	Target Neighborhood Hits	141	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

CABP5_HUMAN
NC score	0.044914 (rank : 96)	θ value	0.0330416 (rank : 49)
Query Neighborhood Hits	133	Target Neighborhood Hits	197	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

VPS72_HUMAN
NC score	0.038823 (rank : 97)	θ value	0.0330416 (rank : 52)
Query Neighborhood Hits	133	Target Neighborhood Hits	274	Shared Neighborhood Hits	6
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

VPS72_MOUSE
NC score	0.037450 (rank : 98)	θ value	0.0431538 (rank : 55)
Query Neighborhood Hits	133	Target Neighborhood Hits	286	Shared Neighborhood Hits	8
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

TRPV1_HUMAN
NC score	0.037084 (rank : 99)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	133	Target Neighborhood Hits	184	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
NC score	0.025778 (rank : 100)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	133	Target Neighborhood Hits	189	Shared Neighborhood Hits	19
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TGON2_HUMAN
NC score	0.016970 (rank : 101)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	133	Target Neighborhood Hits	1037	Shared Neighborhood Hits	19
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TRPM2_MOUSE
NC score	0.016905 (rank : 102)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	133	Target Neighborhood Hits	61	Shared Neighborhood Hits	18
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRM6_HUMAN
NC score	0.012453 (rank : 103)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	133	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJA5, Q76P92, Q9BQV5, Q9ULR7	Gene names	TRM6, KIAA1153
Domain Architecture	No domain graphic available
Description	tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6).

SFR17_HUMAN
NC score	0.011567 (rank : 104)	θ value	1.38821 (rank : 88)
Query Neighborhood Hits	133	Target Neighborhood Hits	325	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TF01, Q5T064, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8TF00, Q96K10, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3	Gene names	SRRP130, C6orf111
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 130 (Serine-arginine-rich- splicing regulatory protein 130) (SRrp130) (SR-rich protein) (SR- related protein).

ARI1B_HUMAN
NC score	0.009417 (rank : 105)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	133	Target Neighborhood Hits	567	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

TNR6A_HUMAN
NC score	0.009303 (rank : 106)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	133	Target Neighborhood Hits	343	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

NCOA2_HUMAN
NC score	0.009065 (rank : 107)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	133	Target Neighborhood Hits	281	Shared Neighborhood Hits	7
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

F10A1_HUMAN
NC score	0.008851 (rank : 108)	θ value	1.38821 (rank : 87)
Query Neighborhood Hits	133	Target Neighborhood Hits	312	Shared Neighborhood Hits	6
SwissProt Accessions	P50502, O14999	Gene names	ST13, FAM10A1, HIP, SNC6
Domain Architecture
Description	Hsc70-interacting protein (Hip) (Suppression of tumorigenicity protein 13) (Putative tumor suppressor ST13) (Protein FAM10A1) (Progesterone receptor-associated p48 protein) (NY-REN-33 antigen).

SMBP2_MOUSE
NC score	0.008658 (rank : 109)	θ value	1.38821 (rank : 89)
Query Neighborhood Hits	133	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

APBA1_HUMAN
NC score	0.008501 (rank : 110)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	133	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

KCD12_MOUSE
NC score	0.008328 (rank : 111)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	133	Target Neighborhood Hits	66	Shared Neighborhood Hits	14
SwissProt Accessions	Q6WVG3	Gene names	Kctd12, Pfet1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain).

NSBP1_MOUSE
NC score	0.007399 (rank : 112)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	133	Target Neighborhood Hits	681	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

FLNB_HUMAN
NC score	0.007254 (rank : 113)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	133	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

NCOA2_MOUSE
NC score	0.007110 (rank : 114)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	133	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

F10A5_HUMAN
NC score	0.006828 (rank : 115)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	133	Target Neighborhood Hits	277	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFI4	Gene names	FAM10A5
Domain Architecture	No domain graphic available
Description	Protein FAM10A5.

ZO1_MOUSE
NC score	0.006585 (rank : 116)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	133	Target Neighborhood Hits	453	Shared Neighborhood Hits	4
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MAGD1_MOUSE
NC score	0.006512 (rank : 117)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	133	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

FLNB_MOUSE
NC score	0.006339 (rank : 118)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	133	Target Neighborhood Hits	126	Shared Neighborhood Hits	5
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

HPS1_MOUSE
NC score	0.005956 (rank : 119)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	133	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	O08983, O35155, O35725, O35950	Gene names	Hps1, Ep, Hps
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 1 protein homolog.

CALB1_HUMAN
NC score	0.005271 (rank : 120)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	133	Target Neighborhood Hits	130	Shared Neighborhood Hits	7
SwissProt Accessions	P05937	Gene names	CALB1, CAB27
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K).

CALB1_MOUSE
NC score	0.005166 (rank : 121)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	133	Target Neighborhood Hits	129	Shared Neighborhood Hits	7
SwissProt Accessions	P12658, Q545N6	Gene names	Calb1
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K) (Spot 35 protein) (PCD-29).

AKAP2_HUMAN
NC score	0.004583 (rank : 122)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	133	Target Neighborhood Hits	507	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

UBP28_MOUSE
NC score	0.004205 (rank : 123)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	133	Target Neighborhood Hits	178	Shared Neighborhood Hits	5
SwissProt Accessions	Q5I043, Q6NZP3, Q6ZPP1, Q8BWI1	Gene names	Usp28, Kiaa1515
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

ASPM_MOUSE
NC score	0.004020 (rank : 124)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	133	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CJ27, O88482, Q8BJI8, Q8BKT4	Gene names	Aspm, Calmbp1, Sha1
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein homolog (Calmodulin-binding protein 1) (Spindle and hydroxyurea checkpoint abnormal protein) (Calmodulin-binding protein Sha1).

NOG1_MOUSE
NC score	0.003994 (rank : 125)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	133	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q99ME9, Q99K16, Q99P78, Q9CT02	Gene names	Gtpbp4, Crfg, Nog1
Domain Architecture
Description	Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB).

PEDF_MOUSE
NC score	0.003739 (rank : 126)	θ value	0.813845 (rank : 80)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	P97298, O70629, O88691	Gene names	Serpinf1, Pedf, Sdf3
Domain Architecture
Description	Pigment epithelium-derived factor precursor (PEDF) (Serpin-F1) (Stromal cell-derived factor 3) (SDF-3) (Caspin).

PI2R_HUMAN
NC score	0.003158 (rank : 127)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	133	Target Neighborhood Hits	290	Shared Neighborhood Hits	3
SwissProt Accessions	P43119	Gene names	PTGIR, PRIPR
Domain Architecture
Description	Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) (Prostaglandin I2 receptor).

OSBP1_HUMAN
NC score	0.002472 (rank : 128)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	133	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

SPTN5_HUMAN
NC score	0.002356 (rank : 129)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	133	Target Neighborhood Hits	674	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

RRBP1_HUMAN
NC score	0.002000 (rank : 130)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	133	Target Neighborhood Hits	1306	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

CBP_MOUSE
NC score	0.001631 (rank : 131)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	133	Target Neighborhood Hits	1051	Shared Neighborhood Hits	13
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

ABCF1_MOUSE
NC score	0.001426 (rank : 132)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	133	Target Neighborhood Hits	321	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P542, Q6NV71	Gene names	Abcf1
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 1.

ITB3_HUMAN
NC score	0.001184 (rank : 133)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	133	Target Neighborhood Hits	325	Shared Neighborhood Hits	2
SwissProt Accessions	P05106, O15495, Q13413, Q14648, Q16499	Gene names	ITGB3, GP3A
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

GP124_MOUSE
NC score	0.000615 (rank : 134)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	133	Target Neighborhood Hits	423	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

41_MOUSE
NC score	0.000307 (rank : 135)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	133	Target Neighborhood Hits	184	Shared Neighborhood Hits	4
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

IFT81_MOUSE
NC score	-0.003178 (rank : 136)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	133	Target Neighborhood Hits	959	Shared Neighborhood Hits	7
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

AAK1_HUMAN
NC score	-0.003330 (rank : 137)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	133	Target Neighborhood Hits	1077	Shared Neighborhood Hits	6
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

FYCO1_HUMAN
NC score	-0.003346 (rank : 138)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	133	Target Neighborhood Hits	1149	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

RAI14_HUMAN
NC score	-0.004718 (rank : 139)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	133	Target Neighborhood Hits	1367	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

NEK1_HUMAN
NC score	-0.005882 (rank : 140)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	133	Target Neighborhood Hits	1129	Shared Neighborhood Hits	4
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).