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Network neighborhood for query Sequence : OSBP1_HUMAN

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OSBP1_HUMAN
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

OSBP1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	180	Target Neighborhood Hits	180	Shared Neighborhood Hits	180
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBP2_HUMAN
θ value	0 (rank : 2)	NC score	0.974829 (rank : 2)
Query Neighborhood Hits	180	Target Neighborhood Hits	154	Shared Neighborhood Hits	69
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

OSBP2_MOUSE
θ value	0 (rank : 3)	NC score	0.972015 (rank : 3)
Query Neighborhood Hits	180	Target Neighborhood Hits	150	Shared Neighborhood Hits	69
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

OSBL1_HUMAN
θ value	7.19216e-82 (rank : 4)	NC score	0.623133 (rank : 19)
Query Neighborhood Hits	180	Target Neighborhood Hits	368	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL1_MOUSE
θ value	1.2268e-81 (rank : 5)	NC score	0.637165 (rank : 18)
Query Neighborhood Hits	180	Target Neighborhood Hits	336	Shared Neighborhood Hits	37
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL3_MOUSE
θ value	3.23591e-74 (rank : 6)	NC score	0.889397 (rank : 7)
Query Neighborhood Hits	180	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL3_HUMAN
θ value	4.67263e-73 (rank : 7)	NC score	0.887020 (rank : 8)
Query Neighborhood Hits	180	Target Neighborhood Hits	93	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL2_MOUSE
θ value	1.15091e-71 (rank : 8)	NC score	0.893362 (rank : 4)
Query Neighborhood Hits	180	Target Neighborhood Hits	22	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BX94, Q3TCK8, Q8R0H8	Gene names	Osbpl2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL2_HUMAN
θ value	6.31527e-70 (rank : 9)	NC score	0.893286 (rank : 5)
Query Neighborhood Hits	180	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1P3, Q9BZB1, Q9Y4B8	Gene names	OSBPL2, KIAA0772, ORP2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL6_MOUSE
θ value	1.31681e-67 (rank : 10)	NC score	0.876192 (rank : 10)
Query Neighborhood Hits	180	Target Neighborhood Hits	105	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL7_HUMAN
θ value	1.45591e-66 (rank : 11)	NC score	0.891433 (rank : 6)
Query Neighborhood Hits	180	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

OSBL6_HUMAN
θ value	5.53243e-66 (rank : 12)	NC score	0.878628 (rank : 9)
Query Neighborhood Hits	180	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSB11_MOUSE
θ value	2.43343e-21 (rank : 13)	NC score	0.693366 (rank : 12)
Query Neighborhood Hits	180	Target Neighborhood Hits	71	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_HUMAN
θ value	4.15078e-21 (rank : 14)	NC score	0.683649 (rank : 16)
Query Neighborhood Hits	180	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSBL8_HUMAN
θ value	5.42112e-21 (rank : 15)	NC score	0.676234 (rank : 17)
Query Neighborhood Hits	180	Target Neighborhood Hits	289	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PKHA3_MOUSE
θ value	2.27762e-19 (rank : 16)	NC score	0.580581 (rank : 20)
Query Neighborhood Hits	180	Target Neighborhood Hits	67	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_HUMAN
θ value	2.97466e-19 (rank : 17)	NC score	0.564165 (rank : 21)
Query Neighborhood Hits	180	Target Neighborhood Hits	66	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

OSBL5_HUMAN
θ value	2.5182e-18 (rank : 18)	NC score	0.688193 (rank : 14)
Query Neighborhood Hits	180	Target Neighborhood Hits	117	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL9_HUMAN
θ value	3.28887e-18 (rank : 19)	NC score	0.716550 (rank : 11)
Query Neighborhood Hits	180	Target Neighborhood Hits	138	Shared Neighborhood Hits	70
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSBL5_MOUSE
θ value	1.63225e-17 (rank : 20)	NC score	0.684812 (rank : 15)
Query Neighborhood Hits	180	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

C43BP_MOUSE
θ value	4.44505e-15 (rank : 21)	NC score	0.497453 (rank : 23)
Query Neighborhood Hits	180	Target Neighborhood Hits	91	Shared Neighborhood Hits	59
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_HUMAN
θ value	7.58209e-15 (rank : 22)	NC score	0.500579 (rank : 22)
Query Neighborhood Hits	180	Target Neighborhood Hits	87	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OSB10_HUMAN
θ value	4.16044e-13 (rank : 23)	NC score	0.692323 (rank : 13)
Query Neighborhood Hits	180	Target Neighborhood Hits	55	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

DDEF1_MOUSE
θ value	1.87187e-05 (rank : 24)	NC score	0.153967 (rank : 30)
Query Neighborhood Hits	180	Target Neighborhood Hits	592	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

PKHA6_HUMAN
θ value	3.19293e-05 (rank : 25)	NC score	0.200995 (rank : 24)
Query Neighborhood Hits	180	Target Neighborhood Hits	556	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	7.1131e-05 (rank : 26)	NC score	0.193034 (rank : 25)
Query Neighborhood Hits	180	Target Neighborhood Hits	591	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DDEF2_HUMAN
θ value	9.29e-05 (rank : 27)	NC score	0.121536 (rank : 48)
Query Neighborhood Hits	180	Target Neighborhood Hits	599	Shared Neighborhood Hits	46
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.000121331 (rank : 28)	NC score	0.121220 (rank : 50)
Query Neighborhood Hits	180	Target Neighborhood Hits	625	Shared Neighborhood Hits	49
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

MYO10_HUMAN
θ value	0.000121331 (rank : 29)	NC score	0.099894 (rank : 60)
Query Neighborhood Hits	180	Target Neighborhood Hits	920	Shared Neighborhood Hits	111
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

SWP70_HUMAN
θ value	0.000786445 (rank : 30)	NC score	0.150783 (rank : 34)
Query Neighborhood Hits	180	Target Neighborhood Hits	973	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH4_MOUSE
θ value	0.00102713 (rank : 31)	NC score	0.158091 (rank : 26)
Query Neighborhood Hits	180	Target Neighborhood Hits	134	Shared Neighborhood Hits	66
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PKHA5_HUMAN
θ value	0.00134147 (rank : 32)	NC score	0.152365 (rank : 32)
Query Neighborhood Hits	180	Target Neighborhood Hits	455	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CYH4_HUMAN
θ value	0.00175202 (rank : 33)	NC score	0.156448 (rank : 28)
Query Neighborhood Hits	180	Target Neighborhood Hits	135	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PKHA4_HUMAN
θ value	0.00228821 (rank : 34)	NC score	0.156638 (rank : 27)
Query Neighborhood Hits	180	Target Neighborhood Hits	283	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

GAB2_MOUSE
θ value	0.00390308 (rank : 35)	NC score	0.109431 (rank : 55)
Query Neighborhood Hits	180	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

RHG25_MOUSE
θ value	0.00665767 (rank : 36)	NC score	0.130087 (rank : 37)
Query Neighborhood Hits	180	Target Neighborhood Hits	492	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH3_MOUSE
θ value	0.0113563 (rank : 37)	NC score	0.142490 (rank : 36)
Query Neighborhood Hits	180	Target Neighborhood Hits	148	Shared Neighborhood Hits	66
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

SWP70_MOUSE
θ value	0.0113563 (rank : 38)	NC score	0.145550 (rank : 35)
Query Neighborhood Hits	180	Target Neighborhood Hits	1097	Shared Neighborhood Hits	116
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RHG25_HUMAN
θ value	0.0148317 (rank : 39)	NC score	0.129791 (rank : 39)
Query Neighborhood Hits	180	Target Neighborhood Hits	550	Shared Neighborhood Hits	91
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CEND2_HUMAN
θ value	0.0252991 (rank : 40)	NC score	0.097652 (rank : 61)
Query Neighborhood Hits	180	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

FBX41_MOUSE
θ value	0.0431538 (rank : 41)	NC score	0.053423 (rank : 89)
Query Neighborhood Hits	180	Target Neighborhood Hits	430	Shared Neighborhood Hits	32
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

MYH10_HUMAN
θ value	0.0431538 (rank : 42)	NC score	0.039519 (rank : 110)
Query Neighborhood Hits	180	Target Neighborhood Hits	1620	Shared Neighborhood Hits	77
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PKHA4_MOUSE
θ value	0.0431538 (rank : 43)	NC score	0.151531 (rank : 33)
Query Neighborhood Hits	180	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH1_HUMAN
θ value	0.0563607 (rank : 44)	NC score	0.128160 (rank : 41)
Query Neighborhood Hits	180	Target Neighborhood Hits	184	Shared Neighborhood Hits	68
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

FBX41_HUMAN
θ value	0.0563607 (rank : 45)	NC score	0.053296 (rank : 91)
Query Neighborhood Hits	180	Target Neighborhood Hits	475	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TF61	Gene names	FBXO41, FBX41, KIAA1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

MYH10_MOUSE
θ value	0.0563607 (rank : 46)	NC score	0.039730 (rank : 109)
Query Neighborhood Hits	180	Target Neighborhood Hits	1612	Shared Neighborhood Hits	75
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PLEK2_HUMAN
θ value	0.0563607 (rank : 47)	NC score	0.154409 (rank : 29)
Query Neighborhood Hits	180	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

URP2_HUMAN
θ value	0.0563607 (rank : 48)	NC score	0.074442 (rank : 73)
Query Neighborhood Hits	180	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q86UX7, Q8IUA1, Q8N207, Q9BT48	Gene names	URP2, KIND3, MIG2B
Domain Architecture
Description	Unc-112-related protein 2 (Kindlin-3) (MIG2-like).

AKT2_HUMAN
θ value	0.0736092 (rank : 49)	NC score	0.011590 (rank : 179)
Query Neighborhood Hits	180	Target Neighborhood Hits	878	Shared Neighborhood Hits	36
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CYH2_HUMAN
θ value	0.0736092 (rank : 50)	NC score	0.125914 (rank : 44)
Query Neighborhood Hits	180	Target Neighborhood Hits	175	Shared Neighborhood Hits	62
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.0736092 (rank : 51)	NC score	0.125908 (rank : 45)
Query Neighborhood Hits	180	Target Neighborhood Hits	171	Shared Neighborhood Hits	62
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PKHB1_HUMAN
θ value	0.0736092 (rank : 52)	NC score	0.121308 (rank : 49)
Query Neighborhood Hits	180	Target Neighborhood Hits	46	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

RAI14_HUMAN
θ value	0.0736092 (rank : 53)	NC score	0.048396 (rank : 99)
Query Neighborhood Hits	180	Target Neighborhood Hits	1367	Shared Neighborhood Hits	78
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

URP2_MOUSE
θ value	0.0736092 (rank : 54)	NC score	0.085491 (rank : 70)
Query Neighborhood Hits	180	Target Neighborhood Hits	37	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K1B8	Gene names	Urp2, Kind3
Domain Architecture
Description	Unc-112-related protein 2 (Kindlin-3).

CYH1_MOUSE
θ value	0.0961366 (rank : 55)	NC score	0.125220 (rank : 46)
Query Neighborhood Hits	180	Target Neighborhood Hits	176	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DOCK9_HUMAN
θ value	0.0961366 (rank : 56)	NC score	0.049339 (rank : 97)
Query Neighborhood Hits	180	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

K1C10_MOUSE
θ value	0.0961366 (rank : 57)	NC score	0.016727 (rank : 166)
Query Neighborhood Hits	180	Target Neighborhood Hits	466	Shared Neighborhood Hits	44
SwissProt Accessions	P02535, P08731, Q8BUX3, Q8BV09, Q8BVU3, Q9CXH6, Q9JKB4	Gene names	Krt10, Krt1-10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10) (56 kDa cytokeratin) (Keratin, type I cytoskeletal 59 kDa).

PKHB1_MOUSE
θ value	0.0961366 (rank : 58)	NC score	0.119610 (rank : 52)
Query Neighborhood Hits	180	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

KMHN1_MOUSE
θ value	0.125558 (rank : 59)	NC score	0.038540 (rank : 115)
Query Neighborhood Hits	180	Target Neighborhood Hits	949	Shared Neighborhood Hits	55
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

PLEK2_MOUSE
θ value	0.125558 (rank : 60)	NC score	0.153921 (rank : 31)
Query Neighborhood Hits	180	Target Neighborhood Hits	96	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

AKT1_MOUSE
θ value	0.163984 (rank : 61)	NC score	0.012538 (rank : 177)
Query Neighborhood Hits	180	Target Neighborhood Hits	878	Shared Neighborhood Hits	39
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

CCD41_HUMAN
θ value	0.163984 (rank : 62)	NC score	0.039080 (rank : 113)
Query Neighborhood Hits	180	Target Neighborhood Hits	1139	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

SFR12_HUMAN
θ value	0.163984 (rank : 63)	NC score	0.024815 (rank : 150)
Query Neighborhood Hits	180	Target Neighborhood Hits	553	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

TARA_MOUSE
θ value	0.163984 (rank : 64)	NC score	0.105950 (rank : 57)
Query Neighborhood Hits	180	Target Neighborhood Hits	1133	Shared Neighborhood Hits	90
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

DDFL1_MOUSE
θ value	0.21417 (rank : 65)	NC score	0.103829 (rank : 58)
Query Neighborhood Hits	180	Target Neighborhood Hits	324	Shared Neighborhood Hits	36
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

GRIN1_HUMAN
θ value	0.21417 (rank : 66)	NC score	0.019497 (rank : 160)
Query Neighborhood Hits	180	Target Neighborhood Hits	681	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

AKT1_HUMAN
θ value	0.279714 (rank : 67)	NC score	0.012425 (rank : 178)
Query Neighborhood Hits	180	Target Neighborhood Hits	885	Shared Neighborhood Hits	40
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

CYH3_HUMAN
θ value	0.279714 (rank : 68)	NC score	0.123629 (rank : 47)
Query Neighborhood Hits	180	Target Neighborhood Hits	137	Shared Neighborhood Hits	59
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DAPP1_MOUSE
θ value	0.279714 (rank : 69)	NC score	0.106793 (rank : 56)
Query Neighborhood Hits	180	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

MRIP_MOUSE
θ value	0.279714 (rank : 70)	NC score	0.096932 (rank : 62)
Query Neighborhood Hits	180	Target Neighborhood Hits	569	Shared Neighborhood Hits	80
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

VDP_HUMAN
θ value	0.279714 (rank : 71)	NC score	0.038276 (rank : 117)
Query Neighborhood Hits	180	Target Neighborhood Hits	645	Shared Neighborhood Hits	51
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

CENPE_HUMAN
θ value	0.365318 (rank : 72)	NC score	0.028708 (rank : 142)
Query Neighborhood Hits	180	Target Neighborhood Hits	2060	Shared Neighborhood Hits	79
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

DOCK9_MOUSE
θ value	0.365318 (rank : 73)	NC score	0.037739 (rank : 120)
Query Neighborhood Hits	180	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

MTMRD_HUMAN
θ value	0.365318 (rank : 74)	NC score	0.119347 (rank : 53)
Query Neighborhood Hits	180	Target Neighborhood Hits	135	Shared Neighborhood Hits	61
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

MY18A_HUMAN
θ value	0.365318 (rank : 75)	NC score	0.036845 (rank : 121)
Query Neighborhood Hits	180	Target Neighborhood Hits	1929	Shared Neighborhood Hits	72
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NUMA1_HUMAN
θ value	0.365318 (rank : 76)	NC score	0.034443 (rank : 128)
Query Neighborhood Hits	180	Target Neighborhood Hits	1523	Shared Neighborhood Hits	74
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

TARA_HUMAN
θ value	0.365318 (rank : 77)	NC score	0.068608 (rank : 80)
Query Neighborhood Hits	180	Target Neighborhood Hits	1626	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TRNT1_HUMAN
θ value	0.365318 (rank : 78)	NC score	0.042779 (rank : 104)
Query Neighborhood Hits	180	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q96Q11, Q8ND57, Q9BS97, Q9Y362	Gene names	TRNT1
Domain Architecture
Description	tRNA-nucleotidyltransferase 1, mitochondrial precursor (EC 2.7.7.25) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt tRNA adenylyltransferase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA CCA- diphosphorylase) (mt CCA-adding enzyme).

TRNT1_MOUSE
θ value	0.365318 (rank : 79)	NC score	0.042824 (rank : 103)
Query Neighborhood Hits	180	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K1J6, Q3TKW1, Q3UX99, Q920N6, Q9CSX0	Gene names	Trnt1
Domain Architecture
Description	tRNA-nucleotidyltransferase 1, mitochondrial precursor (EC 2.7.7.25) (mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt tRNA adenylyltransferase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA CCA- diphosphorylase) (mt CCA-adding enzyme).

ZRF1_HUMAN
θ value	0.365318 (rank : 80)	NC score	0.028099 (rank : 146)
Query Neighborhood Hits	180	Target Neighborhood Hits	457	Shared Neighborhood Hits	29
SwissProt Accessions	Q99543	Gene names	ZRF1, DNAJC2, MPHOSPH11, MPP11
Domain Architecture
Description	Zuotin-related factor 1 (M-phase phosphoprotein 11).

AKT2_MOUSE
θ value	0.47712 (rank : 81)	NC score	0.010961 (rank : 180)
Query Neighborhood Hits	180	Target Neighborhood Hits	875	Shared Neighborhood Hits	36
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CO002_HUMAN
θ value	0.47712 (rank : 82)	NC score	0.023694 (rank : 152)
Query Neighborhood Hits	180	Target Neighborhood Hits	387	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

MYH14_MOUSE
θ value	0.47712 (rank : 83)	NC score	0.039479 (rank : 111)
Query Neighborhood Hits	180	Target Neighborhood Hits	1225	Shared Neighborhood Hits	71
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

CEND1_HUMAN
θ value	0.62314 (rank : 84)	NC score	0.092972 (rank : 65)
Query Neighborhood Hits	180	Target Neighborhood Hits	284	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

MLL2_HUMAN
θ value	0.62314 (rank : 85)	NC score	0.018630 (rank : 162)
Query Neighborhood Hits	180	Target Neighborhood Hits	1788	Shared Neighborhood Hits	44
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MTMR5_HUMAN
θ value	0.62314 (rank : 86)	NC score	0.071134 (rank : 76)
Query Neighborhood Hits	180	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

CENG1_HUMAN
θ value	0.813845 (rank : 87)	NC score	0.055921 (rank : 85)
Query Neighborhood Hits	180	Target Neighborhood Hits	544	Shared Neighborhood Hits	25
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	0.813845 (rank : 88)	NC score	0.056527 (rank : 84)
Query Neighborhood Hits	180	Target Neighborhood Hits	531	Shared Neighborhood Hits	26
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_MOUSE
θ value	0.813845 (rank : 89)	NC score	0.054093 (rank : 88)
Query Neighborhood Hits	180	Target Neighborhood Hits	463	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

GAB2_HUMAN
θ value	0.813845 (rank : 90)	NC score	0.094406 (rank : 63)
Query Neighborhood Hits	180	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

MYH11_MOUSE
θ value	0.813845 (rank : 91)	NC score	0.038127 (rank : 118)
Query Neighborhood Hits	180	Target Neighborhood Hits	1777	Shared Neighborhood Hits	74
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PROX1_MOUSE
θ value	0.813845 (rank : 92)	NC score	0.033606 (rank : 130)
Query Neighborhood Hits	180	Target Neighborhood Hits	184	Shared Neighborhood Hits	19
SwissProt Accessions	P48437, O88478, Q3UPV1, Q543D8	Gene names	Prox1
Domain Architecture
Description	Homeobox prospero-like protein PROX1 (PROX 1).

ROCK1_MOUSE
θ value	0.813845 (rank : 93)	NC score	0.017681 (rank : 164)
Query Neighborhood Hits	180	Target Neighborhood Hits	2126	Shared Neighborhood Hits	78
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

SAPS3_HUMAN
θ value	0.813845 (rank : 94)	NC score	0.017544 (rank : 165)
Query Neighborhood Hits	180	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q5H9R7, Q3B7I1, Q3I4Y0, Q3KR35, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3	Gene names	SAPS3, C11orf23, KIAA1558, PP6R3, SAPL
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3 (Sporulation-induced transcript 4- associated protein SAPL) (Protein phosphatase 6 regulatory subunit 3).

TXLNA_HUMAN
θ value	0.813845 (rank : 95)	NC score	0.033491 (rank : 131)
Query Neighborhood Hits	180	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

TXLNA_MOUSE
θ value	0.813845 (rank : 96)	NC score	0.036407 (rank : 122)
Query Neighborhood Hits	180	Target Neighborhood Hits	846	Shared Neighborhood Hits	54
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

CENG2_HUMAN
θ value	1.06291 (rank : 97)	NC score	0.053369 (rank : 90)
Query Neighborhood Hits	180	Target Neighborhood Hits	471	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CJ078_HUMAN
θ value	1.06291 (rank : 98)	NC score	0.029898 (rank : 139)
Query Neighborhood Hits	180	Target Neighborhood Hits	61	Shared Neighborhood Hits	11
SwissProt Accessions	Q86XK3, Q5JT40, Q8WW47	Gene names	C10orf78
Domain Architecture	No domain graphic available
Description	Protein C10orf78.

DYN3_HUMAN
θ value	1.06291 (rank : 99)	NC score	0.027025 (rank : 148)
Query Neighborhood Hits	180	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

BAP29_HUMAN
θ value	1.38821 (rank : 100)	NC score	0.031969 (rank : 135)
Query Neighborhood Hits	180	Target Neighborhood Hits	362	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UHQ4, O95003	Gene names	BCAP29, BAP29
Domain Architecture
Description	B-cell receptor-associated protein 29 (BCR-associated protein Bap29).

CADH2_MOUSE
θ value	1.38821 (rank : 101)	NC score	0.001762 (rank : 194)
Query Neighborhood Hits	180	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	P15116, Q64260	Gene names	Cdh2
Domain Architecture
Description	Cadherin-2 precursor (Neural-cadherin) (N-cadherin) (CDw325 antigen).

K1C10_HUMAN
θ value	1.38821 (rank : 102)	NC score	0.015955 (rank : 168)
Query Neighborhood Hits	180	Target Neighborhood Hits	526	Shared Neighborhood Hits	43
SwissProt Accessions	P13645, Q14664, Q8N175	Gene names	KRT10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10).

MY18A_MOUSE
θ value	1.38821 (rank : 103)	NC score	0.035736 (rank : 125)
Query Neighborhood Hits	180	Target Neighborhood Hits	1989	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PKHA1_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.127673 (rank : 42)
Query Neighborhood Hits	180	Target Neighborhood Hits	127	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	1.38821 (rank : 105)	NC score	0.120634 (rank : 51)
Query Neighborhood Hits	180	Target Neighborhood Hits	120	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

CENG3_HUMAN
θ value	1.81305 (rank : 106)	NC score	0.051581 (rank : 94)
Query Neighborhood Hits	180	Target Neighborhood Hits	455	Shared Neighborhood Hits	21
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

FGD5_HUMAN
θ value	1.81305 (rank : 107)	NC score	0.031236 (rank : 136)
Query Neighborhood Hits	180	Target Neighborhood Hits	235	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

PARP2_HUMAN
θ value	1.81305 (rank : 108)	NC score	0.013252 (rank : 174)
Query Neighborhood Hits	180	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGN5, Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8	Gene names	PARP2, ADPRT2, ADPRTL2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2).

PROX1_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.032555 (rank : 132)
Query Neighborhood Hits	180	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	Q92786, Q5SW76, Q8TB91	Gene names	PROX1
Domain Architecture
Description	Homeobox prospero-like protein PROX1 (PROX 1).

T3JAM_HUMAN
θ value	1.81305 (rank : 110)	NC score	0.039325 (rank : 112)
Query Neighborhood Hits	180	Target Neighborhood Hits	533	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

DAPP1_HUMAN
θ value	2.36792 (rank : 111)	NC score	0.094340 (rank : 64)
Query Neighborhood Hits	180	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GAS8_MOUSE
θ value	2.36792 (rank : 112)	NC score	0.031971 (rank : 134)
Query Neighborhood Hits	180	Target Neighborhood Hits	622	Shared Neighborhood Hits	42
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GOGB1_HUMAN
θ value	2.36792 (rank : 113)	NC score	0.038413 (rank : 116)
Query Neighborhood Hits	180	Target Neighborhood Hits	2297	Shared Neighborhood Hits	85
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

KMHN1_HUMAN
θ value	2.36792 (rank : 114)	NC score	0.036343 (rank : 123)
Query Neighborhood Hits	180	Target Neighborhood Hits	950	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

MYH11_HUMAN
θ value	2.36792 (rank : 115)	NC score	0.038054 (rank : 119)
Query Neighborhood Hits	180	Target Neighborhood Hits	1806	Shared Neighborhood Hits	78
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PKHC1_HUMAN
θ value	2.36792 (rank : 116)	NC score	0.041412 (rank : 105)
Query Neighborhood Hits	180	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q96AC1, Q14840, Q86TY7	Gene names	PLEKHC1, KIND2, MIG2
Domain Architecture
Description	Pleckstrin homology domain-containing family C member 1 (Kindlin-2) (Mitogen-inducible gene 2 protein) (Mig-2).

STX5_MOUSE
θ value	2.36792 (rank : 117)	NC score	0.023262 (rank : 154)
Query Neighborhood Hits	180	Target Neighborhood Hits	69	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K1E0, Q3TM79, Q99J28, Q9JKP2	Gene names	Stx5, Stx5a
Domain Architecture
Description	Syntaxin-5.

BRE1A_MOUSE
θ value	3.0926 (rank : 118)	NC score	0.028628 (rank : 143)
Query Neighborhood Hits	180	Target Neighborhood Hits	1025	Shared Neighborhood Hits	56
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CAC1F_MOUSE
θ value	3.0926 (rank : 119)	NC score	0.005513 (rank : 188)
Query Neighborhood Hits	180	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CEL_HUMAN
θ value	3.0926 (rank : 120)	NC score	0.005811 (rank : 186)
Query Neighborhood Hits	180	Target Neighborhood Hits	896	Shared Neighborhood Hits	14
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CENG3_MOUSE
θ value	3.0926 (rank : 121)	NC score	0.050680 (rank : 96)
Query Neighborhood Hits	180	Target Neighborhood Hits	467	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

EEA1_HUMAN
θ value	3.0926 (rank : 122)	NC score	0.033757 (rank : 129)
Query Neighborhood Hits	180	Target Neighborhood Hits	1796	Shared Neighborhood Hits	80
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

FGD6_MOUSE
θ value	3.0926 (rank : 123)	NC score	0.042932 (rank : 102)
Query Neighborhood Hits	180	Target Neighborhood Hits	282	Shared Neighborhood Hits	41
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

KNTC2_MOUSE
θ value	3.0926 (rank : 124)	NC score	0.031995 (rank : 133)
Query Neighborhood Hits	180	Target Neighborhood Hits	692	Shared Neighborhood Hits	51
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

ARHGC_HUMAN
θ value	4.03905 (rank : 125)	NC score	0.008107 (rank : 181)
Query Neighborhood Hits	180	Target Neighborhood Hits	351	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CI093_HUMAN
θ value	4.03905 (rank : 126)	NC score	0.034766 (rank : 127)
Query Neighborhood Hits	180	Target Neighborhood Hits	1088	Shared Neighborhood Hits	64
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

GNRP_HUMAN
θ value	4.03905 (rank : 127)	NC score	0.054756 (rank : 86)
Query Neighborhood Hits	180	Target Neighborhood Hits	239	Shared Neighborhood Hits	48
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	4.03905 (rank : 128)	NC score	0.049041 (rank : 98)
Query Neighborhood Hits	180	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

HOME2_MOUSE
θ value	4.03905 (rank : 129)	NC score	0.028977 (rank : 141)
Query Neighborhood Hits	180	Target Neighborhood Hits	882	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

MRIP_HUMAN
θ value	4.03905 (rank : 130)	NC score	0.087559 (rank : 68)
Query Neighborhood Hits	180	Target Neighborhood Hits	578	Shared Neighborhood Hits	79
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

P80C_HUMAN
θ value	4.03905 (rank : 131)	NC score	0.020675 (rank : 159)
Query Neighborhood Hits	180	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P38432	Gene names	COIL, CLN80
Domain Architecture	No domain graphic available
Description	Coilin (p80).

PKHC1_MOUSE
θ value	4.03905 (rank : 132)	NC score	0.040294 (rank : 107)
Query Neighborhood Hits	180	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CIB5, Q8C542, Q8K035	Gene names	Plekhc1
Domain Architecture
Description	Pleckstrin homology domain-containing family C member 1.

RAI14_MOUSE
θ value	4.03905 (rank : 133)	NC score	0.046079 (rank : 100)
Query Neighborhood Hits	180	Target Neighborhood Hits	1505	Shared Neighborhood Hits	77
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

UBP8_MOUSE
θ value	4.03905 (rank : 134)	NC score	0.004838 (rank : 192)
Query Neighborhood Hits	180	Target Neighborhood Hits	362	Shared Neighborhood Hits	15
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

APOA1_HUMAN
θ value	5.27518 (rank : 135)	NC score	0.019256 (rank : 161)
Query Neighborhood Hits	180	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	P02647, Q6LDN9, Q6Q785	Gene names	APOA1
Domain Architecture
Description	Apolipoprotein A-I precursor (Apo-AI) (ApoA-I) [Contains: Apolipoprotein A-I(1-242)].

BRE1A_HUMAN
θ value	5.27518 (rank : 136)	NC score	0.027679 (rank : 147)
Query Neighborhood Hits	180	Target Neighborhood Hits	1071	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

DDFL1_HUMAN
θ value	5.27518 (rank : 137)	NC score	0.103786 (rank : 59)
Query Neighborhood Hits	180	Target Neighborhood Hits	353	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DIAP1_MOUSE
θ value	5.27518 (rank : 138)	NC score	0.021943 (rank : 155)
Query Neighborhood Hits	180	Target Neighborhood Hits	839	Shared Neighborhood Hits	49
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

FGD4_MOUSE
θ value	5.27518 (rank : 139)	NC score	0.024212 (rank : 151)
Query Neighborhood Hits	180	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

LAMB2_MOUSE
θ value	5.27518 (rank : 140)	NC score	0.004976 (rank : 191)
Query Neighborhood Hits	180	Target Neighborhood Hits	722	Shared Neighborhood Hits	32
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

MED12_HUMAN
θ value	5.27518 (rank : 141)	NC score	0.017861 (rank : 163)
Query Neighborhood Hits	180	Target Neighborhood Hits	262	Shared Neighborhood Hits	14
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

PO121_MOUSE
θ value	5.27518 (rank : 142)	NC score	0.012882 (rank : 176)
Query Neighborhood Hits	180	Target Neighborhood Hits	345	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

PRC1_MOUSE
θ value	5.27518 (rank : 143)	NC score	0.023434 (rank : 153)
Query Neighborhood Hits	180	Target Neighborhood Hits	382	Shared Neighborhood Hits	35
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

SAPS3_MOUSE
θ value	5.27518 (rank : 144)	NC score	0.013793 (rank : 172)
Query Neighborhood Hits	180	Target Neighborhood Hits	77	Shared Neighborhood Hits	3
SwissProt Accessions	Q922D4, Q6ZPM9, Q8BTW6, Q9D2X9	Gene names	Saps3, D19Ertd703e, Kiaa1558
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3.

TFE2_HUMAN
θ value	5.27518 (rank : 145)	NC score	0.006524 (rank : 184)
Query Neighborhood Hits	180	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

CCD39_HUMAN
θ value	6.88961 (rank : 146)	NC score	0.028368 (rank : 145)
Query Neighborhood Hits	180	Target Neighborhood Hits	868	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

DHX40_HUMAN
θ value	6.88961 (rank : 147)	NC score	0.005320 (rank : 190)
Query Neighborhood Hits	180	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IX18, Q5JPH4, Q8TC86, Q8WY53, Q9BXM1, Q9H6M9	Gene names	DHX40, DDX40
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-) (DEAH box protein 40) (ARG147) (Protein PAD).

DHX40_MOUSE
θ value	6.88961 (rank : 148)	NC score	0.005398 (rank : 189)
Query Neighborhood Hits	180	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PE54, Q8BPH2, Q8CD88, Q9CWN3	Gene names	Dhx40
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-) (DEAH box protein 40).

EEA1_MOUSE
θ value	6.88961 (rank : 149)	NC score	0.031153 (rank : 137)
Query Neighborhood Hits	180	Target Neighborhood Hits	1637	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

ENAH_HUMAN
θ value	6.88961 (rank : 150)	NC score	0.021908 (rank : 156)
Query Neighborhood Hits	180	Target Neighborhood Hits	784	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

FARP1_HUMAN
θ value	6.88961 (rank : 151)	NC score	0.040036 (rank : 108)
Query Neighborhood Hits	180	Target Neighborhood Hits	241	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

GOGA1_MOUSE
θ value	6.88961 (rank : 152)	NC score	0.029639 (rank : 140)
Query Neighborhood Hits	180	Target Neighborhood Hits	994	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

KTN1_MOUSE
θ value	6.88961 (rank : 153)	NC score	0.030687 (rank : 138)
Query Neighborhood Hits	180	Target Neighborhood Hits	1324	Shared Neighborhood Hits	66
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LAMA3_HUMAN
θ value	6.88961 (rank : 154)	NC score	0.015876 (rank : 169)
Query Neighborhood Hits	180	Target Neighborhood Hits	760	Shared Neighborhood Hits	45
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

LRP16_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.013068 (rank : 175)
Query Neighborhood Hits	180	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQ69, Q9UH96	Gene names	LRP16
Domain Architecture
Description	Protein LRP16.

LRP16_MOUSE
θ value	6.88961 (rank : 156)	NC score	0.013294 (rank : 173)
Query Neighborhood Hits	180	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q922B1	Gene names	Lrp16
Domain Architecture
Description	Protein LRP16.

LRRC6_MOUSE
θ value	6.88961 (rank : 157)	NC score	0.007008 (rank : 182)
Query Neighborhood Hits	180	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	O88978, Q9CUG2	Gene names	Lrrc6, Lrtp, Mc2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 6 (Leucine-rich testis-specific protein) (Testis-specific leucine-rich repeat protein).

MYH14_HUMAN
θ value	6.88961 (rank : 158)	NC score	0.035210 (rank : 126)
Query Neighborhood Hits	180	Target Neighborhood Hits	995	Shared Neighborhood Hits	58
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PKHA2_HUMAN
θ value	6.88961 (rank : 159)	NC score	0.118843 (rank : 54)
Query Neighborhood Hits	180	Target Neighborhood Hits	119	Shared Neighborhood Hits	53
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLEK_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.129857 (rank : 38)
Query Neighborhood Hits	180	Target Neighborhood Hits	110	Shared Neighborhood Hits	58
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

SPAG1_MOUSE
θ value	6.88961 (rank : 161)	NC score	0.005732 (rank : 187)
Query Neighborhood Hits	180	Target Neighborhood Hits	218	Shared Neighborhood Hits	10
SwissProt Accessions	Q80ZX8, Q8CCK7, Q9QZJ3, Q9QZJ4	Gene names	Spag1, Tpis
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS).

SYNE2_HUMAN
θ value	6.88961 (rank : 162)	NC score	0.028568 (rank : 144)
Query Neighborhood Hits	180	Target Neighborhood Hits	1323	Shared Neighborhood Hits	64
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

T2_MOUSE
θ value	6.88961 (rank : 163)	NC score	0.015507 (rank : 170)
Query Neighborhood Hits	180	Target Neighborhood Hits	140	Shared Neighborhood Hits	9
SwissProt Accessions	Q06666	Gene names	Srst, T2
Domain Architecture	No domain graphic available
Description	Octapeptide-repeat protein T2.

TEC_MOUSE
θ value	6.88961 (rank : 164)	NC score	0.000801 (rank : 196)
Query Neighborhood Hits	180	Target Neighborhood Hits	1006	Shared Neighborhood Hits	26
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

AT2B2_HUMAN
θ value	8.99809 (rank : 165)	NC score	0.001343 (rank : 195)
Query Neighborhood Hits	180	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q01814, O00766, Q12994, Q16818	Gene names	ATP2B2, PMCA2
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2) (Plasma membrane calcium pump isoform 2) (Plasma membrane calcium ATPase isoform 2).

CEND1_MOUSE
θ value	8.99809 (rank : 166)	NC score	0.072092 (rank : 75)
Query Neighborhood Hits	180	Target Neighborhood Hits	260	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CYTSA_MOUSE
θ value	8.99809 (rank : 167)	NC score	0.026926 (rank : 149)
Query Neighborhood Hits	180	Target Neighborhood Hits	1104	Shared Neighborhood Hits	61
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

EXOC1_MOUSE
θ value	8.99809 (rank : 168)	NC score	0.016331 (rank : 167)
Query Neighborhood Hits	180	Target Neighborhood Hits	190	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R3S6	Gene names	Exoc1, Sec3, Sec3l1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 1 (Exocyst complex component Sec3).

FGD6_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.041321 (rank : 106)
Query Neighborhood Hits	180	Target Neighborhood Hits	237	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FRAT1_HUMAN
θ value	8.99809 (rank : 170)	NC score	0.006980 (rank : 183)
Query Neighborhood Hits	180	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q92837, Q8NE74, Q8TDW9	Gene names	FRAT1
Domain Architecture
Description	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1).

K1C9_HUMAN
θ value	8.99809 (rank : 171)	NC score	0.014903 (rank : 171)
Query Neighborhood Hits	180	Target Neighborhood Hits	526	Shared Neighborhood Hits	41
SwissProt Accessions	P35527, O00109, Q14665	Gene names	KRT9
Domain Architecture
Description	Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9).

MACF1_MOUSE
θ value	8.99809 (rank : 172)	NC score	0.020977 (rank : 158)
Query Neighborhood Hits	180	Target Neighborhood Hits	1313	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MYH9_HUMAN
θ value	8.99809 (rank : 173)	NC score	0.036135 (rank : 124)
Query Neighborhood Hits	180	Target Neighborhood Hits	1762	Shared Neighborhood Hits	79
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
θ value	8.99809 (rank : 174)	NC score	0.038756 (rank : 114)
Query Neighborhood Hits	180	Target Neighborhood Hits	1829	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PHF14_HUMAN
θ value	8.99809 (rank : 175)	NC score	0.006016 (rank : 185)
Query Neighborhood Hits	180	Target Neighborhood Hits	447	Shared Neighborhood Hits	20
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

PHLB1_MOUSE
θ value	8.99809 (rank : 176)	NC score	0.043808 (rank : 101)
Query Neighborhood Hits	180	Target Neighborhood Hits	678	Shared Neighborhood Hits	71
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PKHB2_HUMAN
θ value	8.99809 (rank : 177)	NC score	0.083382 (rank : 71)
Query Neighborhood Hits	180	Target Neighborhood Hits	54	Shared Neighborhood Hits	38
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

SCN4A_HUMAN
θ value	8.99809 (rank : 178)	NC score	0.002472 (rank : 193)
Query Neighborhood Hits	180	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

TACC3_HUMAN
θ value	8.99809 (rank : 179)	NC score	0.021630 (rank : 157)
Query Neighborhood Hits	180	Target Neighborhood Hits	779	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

ZN180_HUMAN
θ value	8.99809 (rank : 180)	NC score	-0.005752 (rank : 197)
Query Neighborhood Hits	180	Target Neighborhood Hits	752	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UJW8, Q9P1U2	Gene names	ZNF180
Domain Architecture
Description	Zinc finger protein 180 (HHZ168).

3BP2_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.052774 (rank : 92)
Query Neighborhood Hits	180	Target Neighborhood Hits	296	Shared Neighborhood Hits	39
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.052661 (rank : 93)
Query Neighborhood Hits	180	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CENA1_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.069594 (rank : 77)
Query Neighborhood Hits	180	Target Neighborhood Hits	87	Shared Neighborhood Hits	47
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.054176 (rank : 87)
Query Neighborhood Hits	180	Target Neighborhood Hits	83	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENB1_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.090570 (rank : 67)
Query Neighborhood Hits	180	Target Neighborhood Hits	383	Shared Neighborhood Hits	61
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.078016 (rank : 72)
Query Neighborhood Hits	180	Target Neighborhood Hits	425	Shared Neighborhood Hits	63
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.090906 (rank : 66)
Query Neighborhood Hits	180	Target Neighborhood Hits	395	Shared Neighborhood Hits	64
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CNKR1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.072927 (rank : 74)
Query Neighborhood Hits	180	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.069163 (rank : 79)
Query Neighborhood Hits	180	Target Neighborhood Hits	197	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.069166 (rank : 78)
Query Neighborhood Hits	180	Target Neighborhood Hits	197	Shared Neighborhood Hits	49
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

GAB1_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.058470 (rank : 82)
Query Neighborhood Hits	180	Target Neighborhood Hits	279	Shared Neighborhood Hits	39
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.056865 (rank : 83)
Query Neighborhood Hits	180	Target Neighborhood Hits	233	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

PKHA2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.127318 (rank : 43)
Query Neighborhood Hits	180	Target Neighborhood Hits	116	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHB2_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.086730 (rank : 69)
Query Neighborhood Hits	180	Target Neighborhood Hits	48	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PLEK_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.129187 (rank : 40)
Query Neighborhood Hits	180	Target Neighborhood Hits	109	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PSD3_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.051350 (rank : 95)
Query Neighborhood Hits	180	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

TBCD2_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.061581 (rank : 81)
Query Neighborhood Hits	180	Target Neighborhood Hits	419	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

Hits sorted by NC score

OSBP1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	180	Target Neighborhood Hits	180	Shared Neighborhood Hits	180
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBP2_HUMAN
NC score	0.974829 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	180	Target Neighborhood Hits	154	Shared Neighborhood Hits	69
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

OSBP2_MOUSE
NC score	0.972015 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	180	Target Neighborhood Hits	150	Shared Neighborhood Hits	69
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

OSBL2_MOUSE
NC score	0.893362 (rank : 4)	θ value	1.15091e-71 (rank : 8)
Query Neighborhood Hits	180	Target Neighborhood Hits	22	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BX94, Q3TCK8, Q8R0H8	Gene names	Osbpl2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL2_HUMAN
NC score	0.893286 (rank : 5)	θ value	6.31527e-70 (rank : 9)
Query Neighborhood Hits	180	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1P3, Q9BZB1, Q9Y4B8	Gene names	OSBPL2, KIAA0772, ORP2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL7_HUMAN
NC score	0.891433 (rank : 6)	θ value	1.45591e-66 (rank : 11)
Query Neighborhood Hits	180	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

OSBL3_MOUSE
NC score	0.889397 (rank : 7)	θ value	3.23591e-74 (rank : 6)
Query Neighborhood Hits	180	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL3_HUMAN
NC score	0.887020 (rank : 8)	θ value	4.67263e-73 (rank : 7)
Query Neighborhood Hits	180	Target Neighborhood Hits	93	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL6_HUMAN
NC score	0.878628 (rank : 9)	θ value	5.53243e-66 (rank : 12)
Query Neighborhood Hits	180	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL6_MOUSE
NC score	0.876192 (rank : 10)	θ value	1.31681e-67 (rank : 10)
Query Neighborhood Hits	180	Target Neighborhood Hits	105	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL9_HUMAN
NC score	0.716550 (rank : 11)	θ value	3.28887e-18 (rank : 19)
Query Neighborhood Hits	180	Target Neighborhood Hits	138	Shared Neighborhood Hits	70
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSB11_MOUSE
NC score	0.693366 (rank : 12)	θ value	2.43343e-21 (rank : 13)
Query Neighborhood Hits	180	Target Neighborhood Hits	71	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB10_HUMAN
NC score	0.692323 (rank : 13)	θ value	4.16044e-13 (rank : 23)
Query Neighborhood Hits	180	Target Neighborhood Hits	55	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

OSBL5_HUMAN
NC score	0.688193 (rank : 14)	θ value	2.5182e-18 (rank : 18)
Query Neighborhood Hits	180	Target Neighborhood Hits	117	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL5_MOUSE
NC score	0.684812 (rank : 15)	θ value	1.63225e-17 (rank : 20)
Query Neighborhood Hits	180	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

OSB11_HUMAN
NC score	0.683649 (rank : 16)	θ value	4.15078e-21 (rank : 14)
Query Neighborhood Hits	180	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSBL8_HUMAN
NC score	0.676234 (rank : 17)	θ value	5.42112e-21 (rank : 15)
Query Neighborhood Hits	180	Target Neighborhood Hits	289	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

OSBL1_MOUSE
NC score	0.637165 (rank : 18)	θ value	1.2268e-81 (rank : 5)
Query Neighborhood Hits	180	Target Neighborhood Hits	336	Shared Neighborhood Hits	37
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL1_HUMAN
NC score	0.623133 (rank : 19)	θ value	7.19216e-82 (rank : 4)
Query Neighborhood Hits	180	Target Neighborhood Hits	368	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

PKHA3_MOUSE
NC score	0.580581 (rank : 20)	θ value	2.27762e-19 (rank : 16)
Query Neighborhood Hits	180	Target Neighborhood Hits	67	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_HUMAN
NC score	0.564165 (rank : 21)	θ value	2.97466e-19 (rank : 17)
Query Neighborhood Hits	180	Target Neighborhood Hits	66	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

C43BP_HUMAN
NC score	0.500579 (rank : 22)	θ value	7.58209e-15 (rank : 22)
Query Neighborhood Hits	180	Target Neighborhood Hits	87	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
NC score	0.497453 (rank : 23)	θ value	4.44505e-15 (rank : 21)
Query Neighborhood Hits	180	Target Neighborhood Hits	91	Shared Neighborhood Hits	59
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PKHA6_HUMAN
NC score	0.200995 (rank : 24)	θ value	3.19293e-05 (rank : 25)
Query Neighborhood Hits	180	Target Neighborhood Hits	556	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.193034 (rank : 25)	θ value	7.1131e-05 (rank : 26)
Query Neighborhood Hits	180	Target Neighborhood Hits	591	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CYH4_MOUSE
NC score	0.158091 (rank : 26)	θ value	0.00102713 (rank : 31)
Query Neighborhood Hits	180	Target Neighborhood Hits	134	Shared Neighborhood Hits	66
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PKHA4_HUMAN
NC score	0.156638 (rank : 27)	θ value	0.00228821 (rank : 34)
Query Neighborhood Hits	180	Target Neighborhood Hits	283	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH4_HUMAN
NC score	0.156448 (rank : 28)	θ value	0.00175202 (rank : 33)
Query Neighborhood Hits	180	Target Neighborhood Hits	135	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PLEK2_HUMAN
NC score	0.154409 (rank : 29)	θ value	0.0563607 (rank : 47)
Query Neighborhood Hits	180	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

DDEF1_MOUSE
NC score	0.153967 (rank : 30)	θ value	1.87187e-05 (rank : 24)
Query Neighborhood Hits	180	Target Neighborhood Hits	592	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

PLEK2_MOUSE
NC score	0.153921 (rank : 31)	θ value	0.125558 (rank : 60)
Query Neighborhood Hits	180	Target Neighborhood Hits	96	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PKHA5_HUMAN
NC score	0.152365 (rank : 32)	θ value	0.00134147 (rank : 32)
Query Neighborhood Hits	180	Target Neighborhood Hits	455	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_MOUSE
NC score	0.151531 (rank : 33)	θ value	0.0431538 (rank : 43)
Query Neighborhood Hits	180	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SWP70_HUMAN
NC score	0.150783 (rank : 34)	θ value	0.000786445 (rank : 30)
Query Neighborhood Hits	180	Target Neighborhood Hits	973	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.145550 (rank : 35)	θ value	0.0113563 (rank : 38)
Query Neighborhood Hits	180	Target Neighborhood Hits	1097	Shared Neighborhood Hits	116
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH3_MOUSE
NC score	0.142490 (rank : 36)	θ value	0.0113563 (rank : 37)
Query Neighborhood Hits	180	Target Neighborhood Hits	148	Shared Neighborhood Hits	66
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

RHG25_MOUSE
NC score	0.130087 (rank : 37)	θ value	0.00665767 (rank : 36)
Query Neighborhood Hits	180	Target Neighborhood Hits	492	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PLEK_HUMAN
NC score	0.129857 (rank : 38)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	180	Target Neighborhood Hits	110	Shared Neighborhood Hits	58
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

RHG25_HUMAN
NC score	0.129791 (rank : 39)	θ value	0.0148317 (rank : 39)
Query Neighborhood Hits	180	Target Neighborhood Hits	550	Shared Neighborhood Hits	91
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PLEK_MOUSE
NC score	0.129187 (rank : 40)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	180	Target Neighborhood Hits	109	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

CYH1_HUMAN
NC score	0.128160 (rank : 41)	θ value	0.0563607 (rank : 44)
Query Neighborhood Hits	180	Target Neighborhood Hits	184	Shared Neighborhood Hits	68
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PKHA1_HUMAN
NC score	0.127673 (rank : 42)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	180	Target Neighborhood Hits	127	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
NC score	0.127318 (rank : 43)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	180	Target Neighborhood Hits	116	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CYH2_HUMAN
NC score	0.125914 (rank : 44)	θ value	0.0736092 (rank : 50)
Query Neighborhood Hits	180	Target Neighborhood Hits	175	Shared Neighborhood Hits	62
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.125908 (rank : 45)	θ value	0.0736092 (rank : 51)
Query Neighborhood Hits	180	Target Neighborhood Hits	171	Shared Neighborhood Hits	62
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH1_MOUSE
NC score	0.125220 (rank : 46)	θ value	0.0961366 (rank : 55)
Query Neighborhood Hits	180	Target Neighborhood Hits	176	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH3_HUMAN
NC score	0.123629 (rank : 47)	θ value	0.279714 (rank : 68)
Query Neighborhood Hits	180	Target Neighborhood Hits	137	Shared Neighborhood Hits	59
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DDEF2_HUMAN
NC score	0.121536 (rank : 48)	θ value	9.29e-05 (rank : 27)
Query Neighborhood Hits	180	Target Neighborhood Hits	599	Shared Neighborhood Hits	46
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PKHB1_HUMAN
NC score	0.121308 (rank : 49)	θ value	0.0736092 (rank : 52)
Query Neighborhood Hits	180	Target Neighborhood Hits	46	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

DDEF2_MOUSE
NC score	0.121220 (rank : 50)	θ value	0.000121331 (rank : 28)
Query Neighborhood Hits	180	Target Neighborhood Hits	625	Shared Neighborhood Hits	49
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PKHA1_MOUSE
NC score	0.120634 (rank : 51)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	180	Target Neighborhood Hits	120	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHB1_MOUSE
NC score	0.119610 (rank : 52)	θ value	0.0961366 (rank : 58)
Query Neighborhood Hits	180	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

MTMRD_HUMAN
NC score	0.119347 (rank : 53)	θ value	0.365318 (rank : 74)
Query Neighborhood Hits	180	Target Neighborhood Hits	135	Shared Neighborhood Hits	61
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

PKHA2_HUMAN
NC score	0.118843 (rank : 54)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	180	Target Neighborhood Hits	119	Shared Neighborhood Hits	53
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

GAB2_MOUSE
NC score	0.109431 (rank : 55)	θ value	0.00390308 (rank : 35)
Query Neighborhood Hits	180	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

DAPP1_MOUSE
NC score	0.106793 (rank : 56)	θ value	0.279714 (rank : 69)
Query Neighborhood Hits	180	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

TARA_MOUSE
NC score	0.105950 (rank : 57)	θ value	0.163984 (rank : 64)
Query Neighborhood Hits	180	Target Neighborhood Hits	1133	Shared Neighborhood Hits	90
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

DDFL1_MOUSE
NC score	0.103829 (rank : 58)	θ value	0.21417 (rank : 65)
Query Neighborhood Hits	180	Target Neighborhood Hits	324	Shared Neighborhood Hits	36
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DDFL1_HUMAN
NC score	0.103786 (rank : 59)	θ value	5.27518 (rank : 137)
Query Neighborhood Hits	180	Target Neighborhood Hits	353	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

MYO10_HUMAN
NC score	0.099894 (rank : 60)	θ value	0.000121331 (rank : 29)
Query Neighborhood Hits	180	Target Neighborhood Hits	920	Shared Neighborhood Hits	111
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CEND2_HUMAN
NC score	0.097652 (rank : 61)	θ value	0.0252991 (rank : 40)
Query Neighborhood Hits	180	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

MRIP_MOUSE
NC score	0.096932 (rank : 62)	θ value	0.279714 (rank : 70)
Query Neighborhood Hits	180	Target Neighborhood Hits	569	Shared Neighborhood Hits	80
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

GAB2_HUMAN
NC score	0.094406 (rank : 63)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	180	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

DAPP1_HUMAN
NC score	0.094340 (rank : 64)	θ value	2.36792 (rank : 111)
Query Neighborhood Hits	180	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CEND1_HUMAN
NC score	0.092972 (rank : 65)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	180	Target Neighborhood Hits	284	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CENB5_HUMAN
NC score	0.090906 (rank : 66)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	180	Target Neighborhood Hits	395	Shared Neighborhood Hits	64
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENB1_HUMAN
NC score	0.090570 (rank : 67)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	180	Target Neighborhood Hits	383	Shared Neighborhood Hits	61
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

MRIP_HUMAN
NC score	0.087559 (rank : 68)	θ value	4.03905 (rank : 130)
Query Neighborhood Hits	180	Target Neighborhood Hits	578	Shared Neighborhood Hits	79
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

PKHB2_MOUSE
NC score	0.086730 (rank : 69)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	180	Target Neighborhood Hits	48	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

URP2_MOUSE
NC score	0.085491 (rank : 70)	θ value	0.0736092 (rank : 54)
Query Neighborhood Hits	180	Target Neighborhood Hits	37	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K1B8	Gene names	Urp2, Kind3
Domain Architecture
Description	Unc-112-related protein 2 (Kindlin-3).

PKHB2_HUMAN
NC score	0.083382 (rank : 71)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	180	Target Neighborhood Hits	54	Shared Neighborhood Hits	38
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

CENB2_HUMAN
NC score	0.078016 (rank : 72)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	180	Target Neighborhood Hits	425	Shared Neighborhood Hits	63
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

URP2_HUMAN
NC score	0.074442 (rank : 73)	θ value	0.0563607 (rank : 48)
Query Neighborhood Hits	180	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q86UX7, Q8IUA1, Q8N207, Q9BT48	Gene names	URP2, KIND3, MIG2B
Domain Architecture
Description	Unc-112-related protein 2 (Kindlin-3) (MIG2-like).

CNKR1_HUMAN
NC score	0.072927 (rank : 74)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	180	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CEND1_MOUSE
NC score	0.072092 (rank : 75)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	180	Target Neighborhood Hits	260	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

MTMR5_HUMAN
NC score	0.071134 (rank : 76)	θ value	0.62314 (rank : 86)
Query Neighborhood Hits	180	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

CENA1_HUMAN
NC score	0.069594 (rank : 77)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	180	Target Neighborhood Hits	87	Shared Neighborhood Hits	47
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CNKR2_MOUSE
NC score	0.069166 (rank : 78)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	180	Target Neighborhood Hits	197	Shared Neighborhood Hits	49
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.069163 (rank : 79)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	180	Target Neighborhood Hits	197	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

TARA_HUMAN
NC score	0.068608 (rank : 80)	θ value	0.365318 (rank : 77)
Query Neighborhood Hits	180	Target Neighborhood Hits	1626	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TBCD2_HUMAN
NC score	0.061581 (rank : 81)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	180	Target Neighborhood Hits	419	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

GAB1_HUMAN
NC score	0.058470 (rank : 82)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	180	Target Neighborhood Hits	279	Shared Neighborhood Hits	39
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
NC score	0.056865 (rank : 83)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	180	Target Neighborhood Hits	233	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CENG1_MOUSE
NC score	0.056527 (rank : 84)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	180	Target Neighborhood Hits	531	Shared Neighborhood Hits	26
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
NC score	0.055921 (rank : 85)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	180	Target Neighborhood Hits	544	Shared Neighborhood Hits	25
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

GNRP_HUMAN
NC score	0.054756 (rank : 86)	θ value	4.03905 (rank : 127)
Query Neighborhood Hits	180	Target Neighborhood Hits	239	Shared Neighborhood Hits	48
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CENA2_HUMAN
NC score	0.054176 (rank : 87)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	180	Target Neighborhood Hits	83	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENG2_MOUSE
NC score	0.054093 (rank : 88)	θ value	0.813845 (rank : 89)
Query Neighborhood Hits	180	Target Neighborhood Hits	463	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

FBX41_MOUSE
NC score	0.053423 (rank : 89)	θ value	0.0431538 (rank : 41)
Query Neighborhood Hits	180	Target Neighborhood Hits	430	Shared Neighborhood Hits	32
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

CENG2_HUMAN
NC score	0.053369 (rank : 90)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	180	Target Neighborhood Hits	471	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

FBX41_HUMAN
NC score	0.053296 (rank : 91)	θ value	0.0563607 (rank : 45)
Query Neighborhood Hits	180	Target Neighborhood Hits	475	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TF61	Gene names	FBXO41, FBX41, KIAA1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

3BP2_HUMAN
NC score	0.052774 (rank : 92)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	180	Target Neighborhood Hits	296	Shared Neighborhood Hits	39
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
NC score	0.052661 (rank : 93)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	180	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CENG3_HUMAN
NC score	0.051581 (rank : 94)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	180	Target Neighborhood Hits	455	Shared Neighborhood Hits	21
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

PSD3_HUMAN
NC score	0.051350 (rank : 95)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	180	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

CENG3_MOUSE
NC score	0.050680 (rank : 96)	θ value	3.0926 (rank : 121)
Query Neighborhood Hits	180	Target Neighborhood Hits	467	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DOCK9_HUMAN
NC score	0.049339 (rank : 97)	θ value	0.0961366 (rank : 56)
Query Neighborhood Hits	180	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

GNRP_MOUSE
NC score	0.049041 (rank : 98)	θ value	4.03905 (rank : 128)
Query Neighborhood Hits	180	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RAI14_HUMAN
NC score	0.048396 (rank : 99)	θ value	0.0736092 (rank : 53)
Query Neighborhood Hits	180	Target Neighborhood Hits	1367	Shared Neighborhood Hits	78
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RAI14_MOUSE
NC score	0.046079 (rank : 100)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	180	Target Neighborhood Hits	1505	Shared Neighborhood Hits	77
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

PHLB1_MOUSE
NC score	0.043808 (rank : 101)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	180	Target Neighborhood Hits	678	Shared Neighborhood Hits	71
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

FGD6_MOUSE
NC score	0.042932 (rank : 102)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	180	Target Neighborhood Hits	282	Shared Neighborhood Hits	41
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

TRNT1_MOUSE
NC score	0.042824 (rank : 103)	θ value	0.365318 (rank : 79)
Query Neighborhood Hits	180	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K1J6, Q3TKW1, Q3UX99, Q920N6, Q9CSX0	Gene names	Trnt1
Domain Architecture
Description	tRNA-nucleotidyltransferase 1, mitochondrial precursor (EC 2.7.7.25) (mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt tRNA adenylyltransferase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA CCA- diphosphorylase) (mt CCA-adding enzyme).

TRNT1_HUMAN
NC score	0.042779 (rank : 104)	θ value	0.365318 (rank : 78)
Query Neighborhood Hits	180	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q96Q11, Q8ND57, Q9BS97, Q9Y362	Gene names	TRNT1
Domain Architecture
Description	tRNA-nucleotidyltransferase 1, mitochondrial precursor (EC 2.7.7.25) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt tRNA adenylyltransferase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA CCA- diphosphorylase) (mt CCA-adding enzyme).

PKHC1_HUMAN
NC score	0.041412 (rank : 105)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	180	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q96AC1, Q14840, Q86TY7	Gene names	PLEKHC1, KIND2, MIG2
Domain Architecture
Description	Pleckstrin homology domain-containing family C member 1 (Kindlin-2) (Mitogen-inducible gene 2 protein) (Mig-2).

FGD6_HUMAN
NC score	0.041321 (rank : 106)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	180	Target Neighborhood Hits	237	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PKHC1_MOUSE
NC score	0.040294 (rank : 107)	θ value	4.03905 (rank : 132)
Query Neighborhood Hits	180	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CIB5, Q8C542, Q8K035	Gene names	Plekhc1
Domain Architecture
Description	Pleckstrin homology domain-containing family C member 1.

FARP1_HUMAN
NC score	0.040036 (rank : 108)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	180	Target Neighborhood Hits	241	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MYH10_MOUSE
NC score	0.039730 (rank : 109)	θ value	0.0563607 (rank : 46)
Query Neighborhood Hits	180	Target Neighborhood Hits	1612	Shared Neighborhood Hits	75
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_HUMAN
NC score	0.039519 (rank : 110)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	180	Target Neighborhood Hits	1620	Shared Neighborhood Hits	77
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH14_MOUSE
NC score	0.039479 (rank : 111)	θ value	0.47712 (rank : 83)
Query Neighborhood Hits	180	Target Neighborhood Hits	1225	Shared Neighborhood Hits	71
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

T3JAM_HUMAN
NC score	0.039325 (rank : 112)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	180	Target Neighborhood Hits	533	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

CCD41_HUMAN
NC score	0.039080 (rank : 113)	θ value	0.163984 (rank : 62)
Query Neighborhood Hits	180	Target Neighborhood Hits	1139	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

MYH9_MOUSE
NC score	0.038756 (rank : 114)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	180	Target Neighborhood Hits	1829	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

KMHN1_MOUSE
NC score	0.038540 (rank : 115)	θ value	0.125558 (rank : 59)
Query Neighborhood Hits	180	Target Neighborhood Hits	949	Shared Neighborhood Hits	55
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

GOGB1_HUMAN
NC score	0.038413 (rank : 116)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	180	Target Neighborhood Hits	2297	Shared Neighborhood Hits	85
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

VDP_HUMAN
NC score	0.038276 (rank : 117)	θ value	0.279714 (rank : 71)
Query Neighborhood Hits	180	Target Neighborhood Hits	645	Shared Neighborhood Hits	51
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

MYH11_MOUSE
NC score	0.038127 (rank : 118)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	180	Target Neighborhood Hits	1777	Shared Neighborhood Hits	74
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_HUMAN
NC score	0.038054 (rank : 119)	θ value	2.36792 (rank : 115)
Query Neighborhood Hits	180	Target Neighborhood Hits	1806	Shared Neighborhood Hits	78
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

DOCK9_MOUSE
NC score	0.037739 (rank : 120)	θ value	0.365318 (rank : 73)
Query Neighborhood Hits	180	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

MY18A_HUMAN
NC score	0.036845 (rank : 121)	θ value	0.365318 (rank : 75)
Query Neighborhood Hits	180	Target Neighborhood Hits	1929	Shared Neighborhood Hits	72
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

TXLNA_MOUSE
NC score	0.036407 (rank : 122)	θ value	0.813845 (rank : 96)
Query Neighborhood Hits	180	Target Neighborhood Hits	846	Shared Neighborhood Hits	54
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

KMHN1_HUMAN
NC score	0.036343 (rank : 123)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	180	Target Neighborhood Hits	950	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

MYH9_HUMAN
NC score	0.036135 (rank : 124)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	180	Target Neighborhood Hits	1762	Shared Neighborhood Hits	79
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MY18A_MOUSE
NC score	0.035736 (rank : 125)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	180	Target Neighborhood Hits	1989	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH14_HUMAN
NC score	0.035210 (rank : 126)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	180	Target Neighborhood Hits	995	Shared Neighborhood Hits	58
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

CI093_HUMAN
NC score	0.034766 (rank : 127)	θ value	4.03905 (rank : 126)
Query Neighborhood Hits	180	Target Neighborhood Hits	1088	Shared Neighborhood Hits	64
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

NUMA1_HUMAN
NC score	0.034443 (rank : 128)	θ value	0.365318 (rank : 76)
Query Neighborhood Hits	180	Target Neighborhood Hits	1523	Shared Neighborhood Hits	74
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

EEA1_HUMAN
NC score	0.033757 (rank : 129)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	180	Target Neighborhood Hits	1796	Shared Neighborhood Hits	80
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

PROX1_MOUSE
NC score	0.033606 (rank : 130)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	180	Target Neighborhood Hits	184	Shared Neighborhood Hits	19
SwissProt Accessions	P48437, O88478, Q3UPV1, Q543D8	Gene names	Prox1
Domain Architecture
Description	Homeobox prospero-like protein PROX1 (PROX 1).

TXLNA_HUMAN
NC score	0.033491 (rank : 131)	θ value	0.813845 (rank : 95)
Query Neighborhood Hits	180	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

PROX1_HUMAN
NC score	0.032555 (rank : 132)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	180	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	Q92786, Q5SW76, Q8TB91	Gene names	PROX1
Domain Architecture
Description	Homeobox prospero-like protein PROX1 (PROX 1).

KNTC2_MOUSE
NC score	0.031995 (rank : 133)	θ value	3.0926 (rank : 124)
Query Neighborhood Hits	180	Target Neighborhood Hits	692	Shared Neighborhood Hits	51
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

GAS8_MOUSE
NC score	0.031971 (rank : 134)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	180	Target Neighborhood Hits	622	Shared Neighborhood Hits	42
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

BAP29_HUMAN
NC score	0.031969 (rank : 135)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	180	Target Neighborhood Hits	362	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UHQ4, O95003	Gene names	BCAP29, BAP29
Domain Architecture
Description	B-cell receptor-associated protein 29 (BCR-associated protein Bap29).

FGD5_HUMAN
NC score	0.031236 (rank : 136)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	180	Target Neighborhood Hits	235	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

EEA1_MOUSE
NC score	0.031153 (rank : 137)	θ value	6.88961 (rank : 149)
Query Neighborhood Hits	180	Target Neighborhood Hits	1637	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

KTN1_MOUSE
NC score	0.030687 (rank : 138)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	180	Target Neighborhood Hits	1324	Shared Neighborhood Hits	66
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

CJ078_HUMAN
NC score	0.029898 (rank : 139)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	180	Target Neighborhood Hits	61	Shared Neighborhood Hits	11
SwissProt Accessions	Q86XK3, Q5JT40, Q8WW47	Gene names	C10orf78
Domain Architecture	No domain graphic available
Description	Protein C10orf78.

GOGA1_MOUSE
NC score	0.029639 (rank : 140)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	180	Target Neighborhood Hits	994	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

HOME2_MOUSE
NC score	0.028977 (rank : 141)	θ value	4.03905 (rank : 129)
Query Neighborhood Hits	180	Target Neighborhood Hits	882	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

CENPE_HUMAN
NC score	0.028708 (rank : 142)	θ value	0.365318 (rank : 72)
Query Neighborhood Hits	180	Target Neighborhood Hits	2060	Shared Neighborhood Hits	79
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

BRE1A_MOUSE
NC score	0.028628 (rank : 143)	θ value	3.0926 (rank : 118)
Query Neighborhood Hits	180	Target Neighborhood Hits	1025	Shared Neighborhood Hits	56
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

SYNE2_HUMAN
NC score	0.028568 (rank : 144)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	180	Target Neighborhood Hits	1323	Shared Neighborhood Hits	64
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

CCD39_HUMAN
NC score	0.028368 (rank : 145)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	180	Target Neighborhood Hits	868	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

ZRF1_HUMAN
NC score	0.028099 (rank : 146)	θ value	0.365318 (rank : 80)
Query Neighborhood Hits	180	Target Neighborhood Hits	457	Shared Neighborhood Hits	29
SwissProt Accessions	Q99543	Gene names	ZRF1, DNAJC2, MPHOSPH11, MPP11
Domain Architecture
Description	Zuotin-related factor 1 (M-phase phosphoprotein 11).

BRE1A_HUMAN
NC score	0.027679 (rank : 147)	θ value	5.27518 (rank : 136)
Query Neighborhood Hits	180	Target Neighborhood Hits	1071	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

DYN3_HUMAN
NC score	0.027025 (rank : 148)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	180	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

CYTSA_MOUSE
NC score	0.026926 (rank : 149)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	180	Target Neighborhood Hits	1104	Shared Neighborhood Hits	61
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

SFR12_HUMAN
NC score	0.024815 (rank : 150)	θ value	0.163984 (rank : 63)
Query Neighborhood Hits	180	Target Neighborhood Hits	553	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

FGD4_MOUSE
NC score	0.024212 (rank : 151)	θ value	5.27518 (rank : 139)
Query Neighborhood Hits	180	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

CO002_HUMAN
NC score	0.023694 (rank : 152)	θ value	0.47712 (rank : 82)
Query Neighborhood Hits	180	Target Neighborhood Hits	387	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

PRC1_MOUSE
NC score	0.023434 (rank : 153)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	180	Target Neighborhood Hits	382	Shared Neighborhood Hits	35
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

STX5_MOUSE
NC score	0.023262 (rank : 154)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	180	Target Neighborhood Hits	69	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K1E0, Q3TM79, Q99J28, Q9JKP2	Gene names	Stx5, Stx5a
Domain Architecture
Description	Syntaxin-5.

DIAP1_MOUSE
NC score	0.021943 (rank : 155)	θ value	5.27518 (rank : 138)
Query Neighborhood Hits	180	Target Neighborhood Hits	839	Shared Neighborhood Hits	49
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

ENAH_HUMAN
NC score	0.021908 (rank : 156)	θ value	6.88961 (rank : 150)
Query Neighborhood Hits	180	Target Neighborhood Hits	784	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

TACC3_HUMAN
NC score	0.021630 (rank : 157)	θ value	8.99809 (rank : 179)
Query Neighborhood Hits	180	Target Neighborhood Hits	779	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

MACF1_MOUSE
NC score	0.020977 (rank : 158)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	180	Target Neighborhood Hits	1313	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

P80C_HUMAN
NC score	0.020675 (rank : 159)	θ value	4.03905 (rank : 131)
Query Neighborhood Hits	180	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P38432	Gene names	COIL, CLN80
Domain Architecture	No domain graphic available
Description	Coilin (p80).

GRIN1_HUMAN
NC score	0.019497 (rank : 160)	θ value	0.21417 (rank : 66)
Query Neighborhood Hits	180	Target Neighborhood Hits	681	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

APOA1_HUMAN
NC score	0.019256 (rank : 161)	θ value	5.27518 (rank : 135)
Query Neighborhood Hits	180	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	P02647, Q6LDN9, Q6Q785	Gene names	APOA1
Domain Architecture
Description	Apolipoprotein A-I precursor (Apo-AI) (ApoA-I) [Contains: Apolipoprotein A-I(1-242)].

MLL2_HUMAN
NC score	0.018630 (rank : 162)	θ value	0.62314 (rank : 85)
Query Neighborhood Hits	180	Target Neighborhood Hits	1788	Shared Neighborhood Hits	44
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MED12_HUMAN
NC score	0.017861 (rank : 163)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	180	Target Neighborhood Hits	262	Shared Neighborhood Hits	14
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

ROCK1_MOUSE
NC score	0.017681 (rank : 164)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	180	Target Neighborhood Hits	2126	Shared Neighborhood Hits	78
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

SAPS3_HUMAN
NC score	0.017544 (rank : 165)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	180	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q5H9R7, Q3B7I1, Q3I4Y0, Q3KR35, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3	Gene names	SAPS3, C11orf23, KIAA1558, PP6R3, SAPL
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3 (Sporulation-induced transcript 4- associated protein SAPL) (Protein phosphatase 6 regulatory subunit 3).

K1C10_MOUSE
NC score	0.016727 (rank : 166)	θ value	0.0961366 (rank : 57)
Query Neighborhood Hits	180	Target Neighborhood Hits	466	Shared Neighborhood Hits	44
SwissProt Accessions	P02535, P08731, Q8BUX3, Q8BV09, Q8BVU3, Q9CXH6, Q9JKB4	Gene names	Krt10, Krt1-10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10) (56 kDa cytokeratin) (Keratin, type I cytoskeletal 59 kDa).

EXOC1_MOUSE
NC score	0.016331 (rank : 167)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	180	Target Neighborhood Hits	190	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R3S6	Gene names	Exoc1, Sec3, Sec3l1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 1 (Exocyst complex component Sec3).

K1C10_HUMAN
NC score	0.015955 (rank : 168)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	180	Target Neighborhood Hits	526	Shared Neighborhood Hits	43
SwissProt Accessions	P13645, Q14664, Q8N175	Gene names	KRT10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10).

LAMA3_HUMAN
NC score	0.015876 (rank : 169)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	180	Target Neighborhood Hits	760	Shared Neighborhood Hits	45
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

T2_MOUSE
NC score	0.015507 (rank : 170)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	180	Target Neighborhood Hits	140	Shared Neighborhood Hits	9
SwissProt Accessions	Q06666	Gene names	Srst, T2
Domain Architecture	No domain graphic available
Description	Octapeptide-repeat protein T2.

K1C9_HUMAN
NC score	0.014903 (rank : 171)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	180	Target Neighborhood Hits	526	Shared Neighborhood Hits	41
SwissProt Accessions	P35527, O00109, Q14665	Gene names	KRT9
Domain Architecture
Description	Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9).

SAPS3_MOUSE
NC score	0.013793 (rank : 172)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	180	Target Neighborhood Hits	77	Shared Neighborhood Hits	3
SwissProt Accessions	Q922D4, Q6ZPM9, Q8BTW6, Q9D2X9	Gene names	Saps3, D19Ertd703e, Kiaa1558
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3.

LRP16_MOUSE
NC score	0.013294 (rank : 173)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	180	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q922B1	Gene names	Lrp16
Domain Architecture
Description	Protein LRP16.

PARP2_HUMAN
NC score	0.013252 (rank : 174)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	180	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGN5, Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8	Gene names	PARP2, ADPRT2, ADPRTL2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2).

LRP16_HUMAN
NC score	0.013068 (rank : 175)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	180	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQ69, Q9UH96	Gene names	LRP16
Domain Architecture
Description	Protein LRP16.

PO121_MOUSE
NC score	0.012882 (rank : 176)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	180	Target Neighborhood Hits	345	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

AKT1_MOUSE
NC score	0.012538 (rank : 177)	θ value	0.163984 (rank : 61)
Query Neighborhood Hits	180	Target Neighborhood Hits	878	Shared Neighborhood Hits	39
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT1_HUMAN
NC score	0.012425 (rank : 178)	θ value	0.279714 (rank : 67)
Query Neighborhood Hits	180	Target Neighborhood Hits	885	Shared Neighborhood Hits	40
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT2_HUMAN
NC score	0.011590 (rank : 179)	θ value	0.0736092 (rank : 49)
Query Neighborhood Hits	180	Target Neighborhood Hits	878	Shared Neighborhood Hits	36
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
NC score	0.010961 (rank : 180)	θ value	0.47712 (rank : 81)
Query Neighborhood Hits	180	Target Neighborhood Hits	875	Shared Neighborhood Hits	36
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

ARHGC_HUMAN
NC score	0.008107 (rank : 181)	θ value	4.03905 (rank : 125)
Query Neighborhood Hits	180	Target Neighborhood Hits	351	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LRRC6_MOUSE
NC score	0.007008 (rank : 182)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	180	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	O88978, Q9CUG2	Gene names	Lrrc6, Lrtp, Mc2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 6 (Leucine-rich testis-specific protein) (Testis-specific leucine-rich repeat protein).

FRAT1_HUMAN
NC score	0.006980 (rank : 183)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	180	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q92837, Q8NE74, Q8TDW9	Gene names	FRAT1
Domain Architecture
Description	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1).

TFE2_HUMAN
NC score	0.006524 (rank : 184)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	180	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

PHF14_HUMAN
NC score	0.006016 (rank : 185)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	180	Target Neighborhood Hits	447	Shared Neighborhood Hits	20
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

CEL_HUMAN
NC score	0.005811 (rank : 186)	θ value	3.0926 (rank : 120)
Query Neighborhood Hits	180	Target Neighborhood Hits	896	Shared Neighborhood Hits	14
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

SPAG1_MOUSE
NC score	0.005732 (rank : 187)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	180	Target Neighborhood Hits	218	Shared Neighborhood Hits	10
SwissProt Accessions	Q80ZX8, Q8CCK7, Q9QZJ3, Q9QZJ4	Gene names	Spag1, Tpis
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS).

CAC1F_MOUSE
NC score	0.005513 (rank : 188)	θ value	3.0926 (rank : 119)
Query Neighborhood Hits	180	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

DHX40_MOUSE
NC score	0.005398 (rank : 189)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	180	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PE54, Q8BPH2, Q8CD88, Q9CWN3	Gene names	Dhx40
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-) (DEAH box protein 40).

DHX40_HUMAN
NC score	0.005320 (rank : 190)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	180	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IX18, Q5JPH4, Q8TC86, Q8WY53, Q9BXM1, Q9H6M9	Gene names	DHX40, DDX40
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-) (DEAH box protein 40) (ARG147) (Protein PAD).

LAMB2_MOUSE
NC score	0.004976 (rank : 191)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	180	Target Neighborhood Hits	722	Shared Neighborhood Hits	32
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

UBP8_MOUSE
NC score	0.004838 (rank : 192)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	180	Target Neighborhood Hits	362	Shared Neighborhood Hits	15
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

SCN4A_HUMAN
NC score	0.002472 (rank : 193)	θ value	8.99809 (rank : 178)
Query Neighborhood Hits	180	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

CADH2_MOUSE
NC score	0.001762 (rank : 194)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	180	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	P15116, Q64260	Gene names	Cdh2
Domain Architecture
Description	Cadherin-2 precursor (Neural-cadherin) (N-cadherin) (CDw325 antigen).

AT2B2_HUMAN
NC score	0.001343 (rank : 195)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	180	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q01814, O00766, Q12994, Q16818	Gene names	ATP2B2, PMCA2
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2) (Plasma membrane calcium pump isoform 2) (Plasma membrane calcium ATPase isoform 2).

TEC_MOUSE
NC score	0.000801 (rank : 196)	θ value	6.88961 (rank : 164)
Query Neighborhood Hits	180	Target Neighborhood Hits	1006	Shared Neighborhood Hits	26
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZN180_HUMAN
NC score	-0.005752 (rank : 197)	θ value	8.99809 (rank : 180)
Query Neighborhood Hits	180	Target Neighborhood Hits	752	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UJW8, Q9P1U2	Gene names	ZNF180
Domain Architecture
Description	Zinc finger protein 180 (HHZ168).