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Network neighborhood for query Sequence : PSD3_HUMAN

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PSD3_HUMAN
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PSD3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	75	Target Neighborhood Hits	75	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_HUMAN
θ value	1.69605e-115 (rank : 2)	NC score	0.938976 (rank : 3)
Query Neighborhood Hits	75	Target Neighborhood Hits	178	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD4_MOUSE
θ value	1.8752e-114 (rank : 3)	NC score	0.956069 (rank : 2)
Query Neighborhood Hits	75	Target Neighborhood Hits	78	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

CYH3_HUMAN
θ value	4.73814e-25 (rank : 4)	NC score	0.774632 (rank : 4)
Query Neighborhood Hits	75	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH1_MOUSE
θ value	6.18819e-25 (rank : 5)	NC score	0.773937 (rank : 5)
Query Neighborhood Hits	75	Target Neighborhood Hits	176	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH3_MOUSE
θ value	3.07116e-24 (rank : 6)	NC score	0.770539 (rank : 9)
Query Neighborhood Hits	75	Target Neighborhood Hits	148	Shared Neighborhood Hits	43
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH1_HUMAN
θ value	5.23862e-24 (rank : 7)	NC score	0.770988 (rank : 8)
Query Neighborhood Hits	75	Target Neighborhood Hits	184	Shared Neighborhood Hits	43
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH2_MOUSE
θ value	7.56453e-23 (rank : 8)	NC score	0.772216 (rank : 7)
Query Neighborhood Hits	75	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
θ value	1.6852e-22 (rank : 9)	NC score	0.772686 (rank : 6)
Query Neighborhood Hits	75	Target Neighborhood Hits	175	Shared Neighborhood Hits	43
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

GBF1_HUMAN
θ value	1.5773e-20 (rank : 10)	NC score	0.755649 (rank : 12)
Query Neighborhood Hits	75	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

BIG1_HUMAN
θ value	1.74391e-19 (rank : 11)	NC score	0.738398 (rank : 13)
Query Neighborhood Hits	75	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

CYH4_HUMAN
θ value	8.65492e-19 (rank : 12)	NC score	0.763484 (rank : 10)
Query Neighborhood Hits	75	Target Neighborhood Hits	135	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	4.29542e-18 (rank : 13)	NC score	0.763310 (rank : 11)
Query Neighborhood Hits	75	Target Neighborhood Hits	134	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

IQEC3_HUMAN
θ value	1.63225e-17 (rank : 14)	NC score	0.736920 (rank : 14)
Query Neighborhood Hits	75	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	1.63225e-17 (rank : 15)	NC score	0.728360 (rank : 17)
Query Neighborhood Hits	75	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC1_HUMAN
θ value	4.74913e-17 (rank : 16)	NC score	0.730433 (rank : 16)
Query Neighborhood Hits	75	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC2_MOUSE
θ value	1.058e-16 (rank : 17)	NC score	0.689718 (rank : 19)
Query Neighborhood Hits	75	Target Neighborhood Hits	417	Shared Neighborhood Hits	30
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC1_MOUSE
θ value	1.38178e-16 (rank : 18)	NC score	0.730476 (rank : 15)
Query Neighborhood Hits	75	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC2_HUMAN
θ value	2.35696e-16 (rank : 19)	NC score	0.688450 (rank : 20)
Query Neighborhood Hits	75	Target Neighborhood Hits	403	Shared Neighborhood Hits	30
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

BIG2_HUMAN
θ value	6.85773e-16 (rank : 20)	NC score	0.726307 (rank : 18)
Query Neighborhood Hits	75	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

SPTN4_HUMAN
θ value	3.89403e-11 (rank : 21)	NC score	0.157741 (rank : 38)
Query Neighborhood Hits	75	Target Neighborhood Hits	570	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SPTN2_HUMAN
θ value	1.25267e-09 (rank : 22)	NC score	0.163844 (rank : 35)
Query Neighborhood Hits	75	Target Neighborhood Hits	535	Shared Neighborhood Hits	24
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

SPTB2_MOUSE
θ value	4.76016e-09 (rank : 23)	NC score	0.144485 (rank : 40)
Query Neighborhood Hits	75	Target Neighborhood Hits	770	Shared Neighborhood Hits	31
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_HUMAN
θ value	4.0297e-08 (rank : 24)	NC score	0.143373 (rank : 41)
Query Neighborhood Hits	75	Target Neighborhood Hits	748	Shared Neighborhood Hits	29
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

FBX8_HUMAN
θ value	1.09739e-05 (rank : 25)	NC score	0.642710 (rank : 22)
Query Neighborhood Hits	75	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

FBX8_MOUSE
θ value	1.09739e-05 (rank : 26)	NC score	0.644210 (rank : 21)
Query Neighborhood Hits	75	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

TIAM1_MOUSE
θ value	1.43324e-05 (rank : 27)	NC score	0.141198 (rank : 44)
Query Neighborhood Hits	75	Target Neighborhood Hits	205	Shared Neighborhood Hits	17
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PKHA6_HUMAN
θ value	1.87187e-05 (rank : 28)	NC score	0.277495 (rank : 23)
Query Neighborhood Hits	75	Target Neighborhood Hits	556	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

TIAM1_HUMAN
θ value	2.44474e-05 (rank : 29)	NC score	0.145137 (rank : 39)
Query Neighborhood Hits	75	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PKHA6_MOUSE
θ value	7.1131e-05 (rank : 30)	NC score	0.270476 (rank : 24)
Query Neighborhood Hits	75	Target Neighborhood Hits	591	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA5_HUMAN
θ value	0.00175202 (rank : 31)	NC score	0.198854 (rank : 32)
Query Neighborhood Hits	75	Target Neighborhood Hits	455	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA2_MOUSE
θ value	0.00509761 (rank : 32)	NC score	0.230688 (rank : 28)
Query Neighborhood Hits	75	Target Neighborhood Hits	116	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA2_HUMAN
θ value	0.0113563 (rank : 33)	NC score	0.212408 (rank : 30)
Query Neighborhood Hits	75	Target Neighborhood Hits	119	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA1_HUMAN
θ value	0.0330416 (rank : 34)	NC score	0.241814 (rank : 26)
Query Neighborhood Hits	75	Target Neighborhood Hits	127	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

RHG12_MOUSE
θ value	0.0330416 (rank : 35)	NC score	0.065526 (rank : 75)
Query Neighborhood Hits	75	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

PKHA1_MOUSE
θ value	0.0431538 (rank : 36)	NC score	0.237566 (rank : 27)
Query Neighborhood Hits	75	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

RHG12_HUMAN
θ value	0.0961366 (rank : 37)	NC score	0.064733 (rank : 78)
Query Neighborhood Hits	75	Target Neighborhood Hits	190	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

AIM1_HUMAN
θ value	0.125558 (rank : 38)	NC score	0.039114 (rank : 101)
Query Neighborhood Hits	75	Target Neighborhood Hits	247	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

AKT1_MOUSE
θ value	0.365318 (rank : 39)	NC score	0.023821 (rank : 109)
Query Neighborhood Hits	75	Target Neighborhood Hits	878	Shared Neighborhood Hits	30
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

PLEK_HUMAN
θ value	0.365318 (rank : 40)	NC score	0.214458 (rank : 29)
Query Neighborhood Hits	75	Target Neighborhood Hits	110	Shared Neighborhood Hits	35
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

AKT1_HUMAN
θ value	0.62314 (rank : 41)	NC score	0.023854 (rank : 108)
Query Neighborhood Hits	75	Target Neighborhood Hits	885	Shared Neighborhood Hits	30
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

NIPBL_HUMAN
θ value	0.62314 (rank : 42)	NC score	0.022190 (rank : 110)
Query Neighborhood Hits	75	Target Neighborhood Hits	1311	Shared Neighborhood Hits	16
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

CNKR2_HUMAN
θ value	0.813845 (rank : 43)	NC score	0.160321 (rank : 37)
Query Neighborhood Hits	75	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.813845 (rank : 44)	NC score	0.161410 (rank : 36)
Query Neighborhood Hits	75	Target Neighborhood Hits	197	Shared Neighborhood Hits	28
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

SRPK2_HUMAN
θ value	1.06291 (rank : 45)	NC score	0.016313 (rank : 117)
Query Neighborhood Hits	75	Target Neighborhood Hits	664	Shared Neighborhood Hits	10
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	1.06291 (rank : 46)	NC score	0.016098 (rank : 120)
Query Neighborhood Hits	75	Target Neighborhood Hits	765	Shared Neighborhood Hits	12
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

UBP53_MOUSE
θ value	1.06291 (rank : 47)	NC score	0.019981 (rank : 113)
Query Neighborhood Hits	75	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

SVIL_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.016260 (rank : 119)
Query Neighborhood Hits	75	Target Neighborhood Hits	232	Shared Neighborhood Hits	4
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

CTRO_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.016310 (rank : 118)
Query Neighborhood Hits	75	Target Neighborhood Hits	2092	Shared Neighborhood Hits	31
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	1.81305 (rank : 50)	NC score	0.016740 (rank : 115)
Query Neighborhood Hits	75	Target Neighborhood Hits	2344	Shared Neighborhood Hits	32
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

STIM1_HUMAN
θ value	1.81305 (rank : 51)	NC score	0.024893 (rank : 104)
Query Neighborhood Hits	75	Target Neighborhood Hits	665	Shared Neighborhood Hits	13
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

CNKR1_HUMAN
θ value	2.36792 (rank : 52)	NC score	0.255173 (rank : 25)
Query Neighborhood Hits	75	Target Neighborhood Hits	154	Shared Neighborhood Hits	24
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

DGKH_HUMAN
θ value	2.36792 (rank : 53)	NC score	0.055000 (rank : 91)
Query Neighborhood Hits	75	Target Neighborhood Hits	255	Shared Neighborhood Hits	29
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

STIM1_MOUSE
θ value	2.36792 (rank : 54)	NC score	0.024866 (rank : 105)
Query Neighborhood Hits	75	Target Neighborhood Hits	660	Shared Neighborhood Hits	12
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

UACA_MOUSE
θ value	2.36792 (rank : 55)	NC score	0.008712 (rank : 126)
Query Neighborhood Hits	75	Target Neighborhood Hits	1620	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

AKT2_HUMAN
θ value	3.0926 (rank : 56)	NC score	0.024084 (rank : 107)
Query Neighborhood Hits	75	Target Neighborhood Hits	878	Shared Neighborhood Hits	28
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	3.0926 (rank : 57)	NC score	0.024244 (rank : 106)
Query Neighborhood Hits	75	Target Neighborhood Hits	875	Shared Neighborhood Hits	26
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_HUMAN
θ value	4.03905 (rank : 58)	NC score	0.020259 (rank : 112)
Query Neighborhood Hits	75	Target Neighborhood Hits	872	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	4.03905 (rank : 59)	NC score	0.020260 (rank : 111)
Query Neighborhood Hits	75	Target Neighborhood Hits	872	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

CEBPZ_HUMAN
θ value	4.03905 (rank : 60)	NC score	0.015660 (rank : 123)
Query Neighborhood Hits	75	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q03701, Q8NE75	Gene names	CEBPZ, CBF2
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

COG3_MOUSE
θ value	4.03905 (rank : 61)	NC score	0.015779 (rank : 122)
Query Neighborhood Hits	75	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CI04	Gene names	Cog3
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 3.

NPBL_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.029747 (rank : 103)
Query Neighborhood Hits	75	Target Neighborhood Hits	1041	Shared Neighborhood Hits	18
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

RABE1_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.015957 (rank : 121)
Query Neighborhood Hits	75	Target Neighborhood Hits	1104	Shared Neighborhood Hits	15
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	5.27518 (rank : 64)	NC score	0.016697 (rank : 116)
Query Neighborhood Hits	75	Target Neighborhood Hits	1105	Shared Neighborhood Hits	18
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

BPA1_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.044582 (rank : 100)
Query Neighborhood Hits	75	Target Neighborhood Hits	1477	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

PRRX1_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.000973 (rank : 130)
Query Neighborhood Hits	75	Target Neighborhood Hits	346	Shared Neighborhood Hits	2
SwissProt Accessions	P63013, P43271, Q02810	Gene names	Prrx1, Pmx, Pmx1
Domain Architecture	No domain graphic available
Description	Paired mesoderm homeobox protein 1 (PRX-1) (Paired-related homeobox protein 1) (Homeobox protein mHox) (Homeobox protein K-2).

STK23_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.010878 (rank : 125)
Query Neighborhood Hits	75	Target Neighborhood Hits	572	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SYNJ2_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.006788 (rank : 127)
Query Neighborhood Hits	75	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

CN145_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.019261 (rank : 114)
Query Neighborhood Hits	75	Target Neighborhood Hits	1196	Shared Neighborhood Hits	21
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CSPG2_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.000993 (rank : 129)
Query Neighborhood Hits	75	Target Neighborhood Hits	711	Shared Neighborhood Hits	5
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

FGD5_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.031171 (rank : 102)
Query Neighborhood Hits	75	Target Neighborhood Hits	235	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

MYO10_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.046299 (rank : 99)
Query Neighborhood Hits	75	Target Neighborhood Hits	920	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PLEK_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.202409 (rank : 31)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PTN22_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.001952 (rank : 128)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

SEPN1_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.014101 (rank : 124)
Query Neighborhood Hits	75	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZV5, Q6PI70, Q969F6, Q9NUI6	Gene names	SEPN1, SELN
Domain Architecture	No domain graphic available
Description	Selenoprotein N precursor.

3BP2_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.124116 (rank : 48)
Query Neighborhood Hits	75	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.126674 (rank : 47)
Query Neighborhood Hits	75	Target Neighborhood Hits	142	Shared Neighborhood Hits	16
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ACTN1_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.066134 (rank : 70)
Query Neighborhood Hits	75	Target Neighborhood Hits	221	Shared Neighborhood Hits	7
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN1_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.066409 (rank : 68)
Query Neighborhood Hits	75	Target Neighborhood Hits	216	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN2_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.064495 (rank : 79)
Query Neighborhood Hits	75	Target Neighborhood Hits	295	Shared Neighborhood Hits	9
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ACTN2_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.064401 (rank : 80)
Query Neighborhood Hits	75	Target Neighborhood Hits	287	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ACTN3_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.065661 (rank : 74)
Query Neighborhood Hits	75	Target Neighborhood Hits	272	Shared Neighborhood Hits	7
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN3_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.065176 (rank : 77)
Query Neighborhood Hits	75	Target Neighborhood Hits	265	Shared Neighborhood Hits	7
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN4_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.065880 (rank : 72)
Query Neighborhood Hits	75	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN4_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.065845 (rank : 73)
Query Neighborhood Hits	75	Target Neighborhood Hits	276	Shared Neighborhood Hits	7
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ANLN_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.114903 (rank : 49)
Query Neighborhood Hits	75	Target Neighborhood Hits	222	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANLN_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.094178 (rank : 52)
Query Neighborhood Hits	75	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CENB1_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.050916 (rank : 97)
Query Neighborhood Hits	75	Target Neighborhood Hits	383	Shared Neighborhood Hits	20
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.076886 (rank : 61)
Query Neighborhood Hits	75	Target Neighborhood Hits	425	Shared Neighborhood Hits	24
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.071318 (rank : 62)
Query Neighborhood Hits	75	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CLMN_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.066326 (rank : 69)
Query Neighborhood Hits	75	Target Neighborhood Hits	205	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

CLMN_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.067793 (rank : 67)
Query Neighborhood Hits	75	Target Neighborhood Hits	180	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

DAPP1_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.130862 (rank : 46)
Query Neighborhood Hits	75	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.136607 (rank : 45)
Query Neighborhood Hits	75	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DYN2_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.058312 (rank : 85)
Query Neighborhood Hits	75	Target Neighborhood Hits	112	Shared Neighborhood Hits	21
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.058274 (rank : 86)
Query Neighborhood Hits	75	Target Neighborhood Hits	104	Shared Neighborhood Hits	21
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN3_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.057783 (rank : 87)
Query Neighborhood Hits	75	Target Neighborhood Hits	158	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

FARP1_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.050264 (rank : 98)
Query Neighborhood Hits	75	Target Neighborhood Hits	241	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

GNRP_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.068885 (rank : 66)
Query Neighborhood Hits	75	Target Neighborhood Hits	239	Shared Neighborhood Hits	23
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.065341 (rank : 76)
Query Neighborhood Hits	75	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MILK1_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.059100 (rank : 83)
Query Neighborhood Hits	75	Target Neighborhood Hits	427	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MILK1_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.061693 (rank : 82)
Query Neighborhood Hits	75	Target Neighborhood Hits	788	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MILK2_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.058979 (rank : 84)
Query Neighborhood Hits	75	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

MTMR5_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.053470 (rank : 93)
Query Neighborhood Hits	75	Target Neighborhood Hits	141	Shared Neighborhood Hits	21
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

OSBP1_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.051350 (rank : 95)
Query Neighborhood Hits	75	Target Neighborhood Hits	180	Shared Neighborhood Hits	21
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PHLB1_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.055561 (rank : 90)
Query Neighborhood Hits	75	Target Neighborhood Hits	1038	Shared Neighborhood Hits	33
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB1_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.053296 (rank : 94)
Query Neighborhood Hits	75	Target Neighborhood Hits	678	Shared Neighborhood Hits	29
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB2_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.055863 (rank : 89)
Query Neighborhood Hits	75	Target Neighborhood Hits	964	Shared Neighborhood Hits	30
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.056241 (rank : 88)
Query Neighborhood Hits	75	Target Neighborhood Hits	1016	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA4_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.165822 (rank : 34)
Query Neighborhood Hits	75	Target Neighborhood Hits	283	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.176912 (rank : 33)
Query Neighborhood Hits	75	Target Neighborhood Hits	202	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHB1_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.070711 (rank : 64)
Query Neighborhood Hits	75	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB1_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.051115 (rank : 96)
Query Neighborhood Hits	75	Target Neighborhood Hits	47	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.080692 (rank : 60)
Query Neighborhood Hits	75	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.085864 (rank : 57)
Query Neighborhood Hits	75	Target Neighborhood Hits	48	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.142033 (rank : 42)
Query Neighborhood Hits	75	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.141787 (rank : 43)
Query Neighborhood Hits	75	Target Neighborhood Hits	96	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

RASA1_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.088395 (rank : 56)
Query Neighborhood Hits	75	Target Neighborhood Hits	258	Shared Neighborhood Hits	26
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG25_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.099962 (rank : 51)
Query Neighborhood Hits	75	Target Neighborhood Hits	550	Shared Neighborhood Hits	41
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.106126 (rank : 50)
Query Neighborhood Hits	75	Target Neighborhood Hits	492	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SMOO_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.063242 (rank : 81)
Query Neighborhood Hits	75	Target Neighborhood Hits	391	Shared Neighborhood Hits	10
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SPTA1_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.069285 (rank : 65)
Query Neighborhood Hits	75	Target Neighborhood Hits	748	Shared Neighborhood Hits	16
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.071223 (rank : 63)
Query Neighborhood Hits	75	Target Neighborhood Hits	675	Shared Neighborhood Hits	16
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.065966 (rank : 71)
Query Neighborhood Hits	75	Target Neighborhood Hits	888	Shared Neighborhood Hits	13
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SPTB1_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.094061 (rank : 53)
Query Neighborhood Hits	75	Target Neighborhood Hits	541	Shared Neighborhood Hits	13
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB1_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.092711 (rank : 54)
Query Neighborhood Hits	75	Target Neighborhood Hits	543	Shared Neighborhood Hits	13
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTN5_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.084347 (rank : 58)
Query Neighborhood Hits	75	Target Neighborhood Hits	674	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

SWP70_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.092391 (rank : 55)
Query Neighborhood Hits	75	Target Neighborhood Hits	973	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.082693 (rank : 59)
Query Neighborhood Hits	75	Target Neighborhood Hits	1097	Shared Neighborhood Hits	43
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TBCD2_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.053481 (rank : 92)
Query Neighborhood Hits	75	Target Neighborhood Hits	419	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

Hits sorted by NC score

PSD3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	75	Target Neighborhood Hits	75	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_MOUSE
NC score	0.956069 (rank : 2)	θ value	1.8752e-114 (rank : 3)
Query Neighborhood Hits	75	Target Neighborhood Hits	78	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PSD4_HUMAN
NC score	0.938976 (rank : 3)	θ value	1.69605e-115 (rank : 2)
Query Neighborhood Hits	75	Target Neighborhood Hits	178	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CYH3_HUMAN
NC score	0.774632 (rank : 4)	θ value	4.73814e-25 (rank : 4)
Query Neighborhood Hits	75	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH1_MOUSE
NC score	0.773937 (rank : 5)	θ value	6.18819e-25 (rank : 5)
Query Neighborhood Hits	75	Target Neighborhood Hits	176	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH2_HUMAN
NC score	0.772686 (rank : 6)	θ value	1.6852e-22 (rank : 9)
Query Neighborhood Hits	75	Target Neighborhood Hits	175	Shared Neighborhood Hits	43
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.772216 (rank : 7)	θ value	7.56453e-23 (rank : 8)
Query Neighborhood Hits	75	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH1_HUMAN
NC score	0.770988 (rank : 8)	θ value	5.23862e-24 (rank : 7)
Query Neighborhood Hits	75	Target Neighborhood Hits	184	Shared Neighborhood Hits	43
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH3_MOUSE
NC score	0.770539 (rank : 9)	θ value	3.07116e-24 (rank : 6)
Query Neighborhood Hits	75	Target Neighborhood Hits	148	Shared Neighborhood Hits	43
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_HUMAN
NC score	0.763484 (rank : 10)	θ value	8.65492e-19 (rank : 12)
Query Neighborhood Hits	75	Target Neighborhood Hits	135	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
NC score	0.763310 (rank : 11)	θ value	4.29542e-18 (rank : 13)
Query Neighborhood Hits	75	Target Neighborhood Hits	134	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

GBF1_HUMAN
NC score	0.755649 (rank : 12)	θ value	1.5773e-20 (rank : 10)
Query Neighborhood Hits	75	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

BIG1_HUMAN
NC score	0.738398 (rank : 13)	θ value	1.74391e-19 (rank : 11)
Query Neighborhood Hits	75	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

IQEC3_HUMAN
NC score	0.736920 (rank : 14)	θ value	1.63225e-17 (rank : 14)
Query Neighborhood Hits	75	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC1_MOUSE
NC score	0.730476 (rank : 15)	θ value	1.38178e-16 (rank : 18)
Query Neighborhood Hits	75	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC1_HUMAN
NC score	0.730433 (rank : 16)	θ value	4.74913e-17 (rank : 16)
Query Neighborhood Hits	75	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC3_MOUSE
NC score	0.728360 (rank : 17)	θ value	1.63225e-17 (rank : 15)
Query Neighborhood Hits	75	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

BIG2_HUMAN
NC score	0.726307 (rank : 18)	θ value	6.85773e-16 (rank : 20)
Query Neighborhood Hits	75	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

IQEC2_MOUSE
NC score	0.689718 (rank : 19)	θ value	1.058e-16 (rank : 17)
Query Neighborhood Hits	75	Target Neighborhood Hits	417	Shared Neighborhood Hits	30
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_HUMAN
NC score	0.688450 (rank : 20)	θ value	2.35696e-16 (rank : 19)
Query Neighborhood Hits	75	Target Neighborhood Hits	403	Shared Neighborhood Hits	30
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

FBX8_MOUSE
NC score	0.644210 (rank : 21)	θ value	1.09739e-05 (rank : 26)
Query Neighborhood Hits	75	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
NC score	0.642710 (rank : 22)	θ value	1.09739e-05 (rank : 25)
Query Neighborhood Hits	75	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

PKHA6_HUMAN
NC score	0.277495 (rank : 23)	θ value	1.87187e-05 (rank : 28)
Query Neighborhood Hits	75	Target Neighborhood Hits	556	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.270476 (rank : 24)	θ value	7.1131e-05 (rank : 30)
Query Neighborhood Hits	75	Target Neighborhood Hits	591	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CNKR1_HUMAN
NC score	0.255173 (rank : 25)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	75	Target Neighborhood Hits	154	Shared Neighborhood Hits	24
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PKHA1_HUMAN
NC score	0.241814 (rank : 26)	θ value	0.0330416 (rank : 34)
Query Neighborhood Hits	75	Target Neighborhood Hits	127	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.237566 (rank : 27)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	75	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
NC score	0.230688 (rank : 28)	θ value	0.00509761 (rank : 32)
Query Neighborhood Hits	75	Target Neighborhood Hits	116	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PLEK_HUMAN
NC score	0.214458 (rank : 29)	θ value	0.365318 (rank : 40)
Query Neighborhood Hits	75	Target Neighborhood Hits	110	Shared Neighborhood Hits	35
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHA2_HUMAN
NC score	0.212408 (rank : 30)	θ value	0.0113563 (rank : 33)
Query Neighborhood Hits	75	Target Neighborhood Hits	119	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLEK_MOUSE
NC score	0.202409 (rank : 31)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PKHA5_HUMAN
NC score	0.198854 (rank : 32)	θ value	0.00175202 (rank : 31)
Query Neighborhood Hits	75	Target Neighborhood Hits	455	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_MOUSE
NC score	0.176912 (rank : 33)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	75	Target Neighborhood Hits	202	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.165822 (rank : 34)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	75	Target Neighborhood Hits	283	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SPTN2_HUMAN
NC score	0.163844 (rank : 35)	θ value	1.25267e-09 (rank : 22)
Query Neighborhood Hits	75	Target Neighborhood Hits	535	Shared Neighborhood Hits	24
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

CNKR2_MOUSE
NC score	0.161410 (rank : 36)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	75	Target Neighborhood Hits	197	Shared Neighborhood Hits	28
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.160321 (rank : 37)	θ value	0.813845 (rank : 43)
Query Neighborhood Hits	75	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

SPTN4_HUMAN
NC score	0.157741 (rank : 38)	θ value	3.89403e-11 (rank : 21)
Query Neighborhood Hits	75	Target Neighborhood Hits	570	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

TIAM1_HUMAN
NC score	0.145137 (rank : 39)	θ value	2.44474e-05 (rank : 29)
Query Neighborhood Hits	75	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SPTB2_MOUSE
NC score	0.144485 (rank : 40)	θ value	4.76016e-09 (rank : 23)
Query Neighborhood Hits	75	Target Neighborhood Hits	770	Shared Neighborhood Hits	31
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_HUMAN
NC score	0.143373 (rank : 41)	θ value	4.0297e-08 (rank : 24)
Query Neighborhood Hits	75	Target Neighborhood Hits	748	Shared Neighborhood Hits	29
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

PLEK2_HUMAN
NC score	0.142033 (rank : 42)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	75	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
NC score	0.141787 (rank : 43)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	75	Target Neighborhood Hits	96	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

TIAM1_MOUSE
NC score	0.141198 (rank : 44)	θ value	1.43324e-05 (rank : 27)
Query Neighborhood Hits	75	Target Neighborhood Hits	205	Shared Neighborhood Hits	17
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

DAPP1_MOUSE
NC score	0.136607 (rank : 45)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	75	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.130862 (rank : 46)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	75	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

3BP2_MOUSE
NC score	0.126674 (rank : 47)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	75	Target Neighborhood Hits	142	Shared Neighborhood Hits	16
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_HUMAN
NC score	0.124116 (rank : 48)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	75	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANLN_HUMAN
NC score	0.114903 (rank : 49)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	75	Target Neighborhood Hits	222	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

RHG25_MOUSE
NC score	0.106126 (rank : 50)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	75	Target Neighborhood Hits	492	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.099962 (rank : 51)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	75	Target Neighborhood Hits	550	Shared Neighborhood Hits	41
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ANLN_MOUSE
NC score	0.094178 (rank : 52)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	75	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

SPTB1_HUMAN
NC score	0.094061 (rank : 53)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	75	Target Neighborhood Hits	541	Shared Neighborhood Hits	13
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB1_MOUSE
NC score	0.092711 (rank : 54)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	75	Target Neighborhood Hits	543	Shared Neighborhood Hits	13
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SWP70_HUMAN
NC score	0.092391 (rank : 55)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	75	Target Neighborhood Hits	973	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RASA1_HUMAN
NC score	0.088395 (rank : 56)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	75	Target Neighborhood Hits	258	Shared Neighborhood Hits	26
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PKHB2_MOUSE
NC score	0.085864 (rank : 57)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	75	Target Neighborhood Hits	48	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

SPTN5_HUMAN
NC score	0.084347 (rank : 58)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	75	Target Neighborhood Hits	674	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

SWP70_MOUSE
NC score	0.082693 (rank : 59)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	75	Target Neighborhood Hits	1097	Shared Neighborhood Hits	43
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHB2_HUMAN
NC score	0.080692 (rank : 60)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	75	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

CENB2_HUMAN
NC score	0.076886 (rank : 61)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	75	Target Neighborhood Hits	425	Shared Neighborhood Hits	24
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
NC score	0.071318 (rank : 62)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	75	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

SPTA1_MOUSE
NC score	0.071223 (rank : 63)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	75	Target Neighborhood Hits	675	Shared Neighborhood Hits	16
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PKHB1_HUMAN
NC score	0.070711 (rank : 64)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	75	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

SPTA1_HUMAN
NC score	0.069285 (rank : 65)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	75	Target Neighborhood Hits	748	Shared Neighborhood Hits	16
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

GNRP_HUMAN
NC score	0.068885 (rank : 66)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	75	Target Neighborhood Hits	239	Shared Neighborhood Hits	23
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CLMN_MOUSE
NC score	0.067793 (rank : 67)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	75	Target Neighborhood Hits	180	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

ACTN1_MOUSE
NC score	0.066409 (rank : 68)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	75	Target Neighborhood Hits	216	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

CLMN_HUMAN
NC score	0.066326 (rank : 69)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	75	Target Neighborhood Hits	205	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

ACTN1_HUMAN
NC score	0.066134 (rank : 70)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	75	Target Neighborhood Hits	221	Shared Neighborhood Hits	7
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

SPTA2_HUMAN
NC score	0.065966 (rank : 71)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	75	Target Neighborhood Hits	888	Shared Neighborhood Hits	13
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ACTN4_HUMAN
NC score	0.065880 (rank : 72)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	75	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN4_MOUSE
NC score	0.065845 (rank : 73)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	75	Target Neighborhood Hits	276	Shared Neighborhood Hits	7
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN3_HUMAN
NC score	0.065661 (rank : 74)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	75	Target Neighborhood Hits	272	Shared Neighborhood Hits	7
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

RHG12_MOUSE
NC score	0.065526 (rank : 75)	θ value	0.0330416 (rank : 35)
Query Neighborhood Hits	75	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GNRP_MOUSE
NC score	0.065341 (rank : 76)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	75	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ACTN3_MOUSE
NC score	0.065176 (rank : 77)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	75	Target Neighborhood Hits	265	Shared Neighborhood Hits	7
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

RHG12_HUMAN
NC score	0.064733 (rank : 78)	θ value	0.0961366 (rank : 37)
Query Neighborhood Hits	75	Target Neighborhood Hits	190	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

ACTN2_HUMAN
NC score	0.064495 (rank : 79)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	75	Target Neighborhood Hits	295	Shared Neighborhood Hits	9
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ACTN2_MOUSE
NC score	0.064401 (rank : 80)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	75	Target Neighborhood Hits	287	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

SMOO_HUMAN
NC score	0.063242 (rank : 81)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	75	Target Neighborhood Hits	391	Shared Neighborhood Hits	10
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

MILK1_MOUSE
NC score	0.061693 (rank : 82)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	75	Target Neighborhood Hits	788	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MILK1_HUMAN
NC score	0.059100 (rank : 83)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	75	Target Neighborhood Hits	427	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MILK2_HUMAN
NC score	0.058979 (rank : 84)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	75	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

DYN2_HUMAN
NC score	0.058312 (rank : 85)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	75	Target Neighborhood Hits	112	Shared Neighborhood Hits	21
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
NC score	0.058274 (rank : 86)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	75	Target Neighborhood Hits	104	Shared Neighborhood Hits	21
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN3_HUMAN
NC score	0.057783 (rank : 87)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	75	Target Neighborhood Hits	158	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

PHLB2_MOUSE
NC score	0.056241 (rank : 88)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	75	Target Neighborhood Hits	1016	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
NC score	0.055863 (rank : 89)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	75	Target Neighborhood Hits	964	Shared Neighborhood Hits	30
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB1_HUMAN
NC score	0.055561 (rank : 90)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	75	Target Neighborhood Hits	1038	Shared Neighborhood Hits	33
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

DGKH_HUMAN
NC score	0.055000 (rank : 91)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	75	Target Neighborhood Hits	255	Shared Neighborhood Hits	29
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

TBCD2_HUMAN
NC score	0.053481 (rank : 92)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	75	Target Neighborhood Hits	419	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

MTMR5_HUMAN
NC score	0.053470 (rank : 93)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	75	Target Neighborhood Hits	141	Shared Neighborhood Hits	21
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PHLB1_MOUSE
NC score	0.053296 (rank : 94)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	75	Target Neighborhood Hits	678	Shared Neighborhood Hits	29
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

OSBP1_HUMAN
NC score	0.051350 (rank : 95)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	75	Target Neighborhood Hits	180	Shared Neighborhood Hits	21
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PKHB1_MOUSE
NC score	0.051115 (rank : 96)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	75	Target Neighborhood Hits	47	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

CENB1_HUMAN
NC score	0.050916 (rank : 97)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	75	Target Neighborhood Hits	383	Shared Neighborhood Hits	20
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

FARP1_HUMAN
NC score	0.050264 (rank : 98)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	75	Target Neighborhood Hits	241	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MYO10_HUMAN
NC score	0.046299 (rank : 99)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	75	Target Neighborhood Hits	920	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

BPA1_MOUSE
NC score	0.044582 (rank : 100)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	75	Target Neighborhood Hits	1477	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

AIM1_HUMAN
NC score	0.039114 (rank : 101)	θ value	0.125558 (rank : 38)
Query Neighborhood Hits	75	Target Neighborhood Hits	247	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

FGD5_HUMAN
NC score	0.031171 (rank : 102)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	75	Target Neighborhood Hits	235	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

NPBL_MOUSE
NC score	0.029747 (rank : 103)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	75	Target Neighborhood Hits	1041	Shared Neighborhood Hits	18
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

STIM1_HUMAN
NC score	0.024893 (rank : 104)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	75	Target Neighborhood Hits	665	Shared Neighborhood Hits	13
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STIM1_MOUSE
NC score	0.024866 (rank : 105)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	75	Target Neighborhood Hits	660	Shared Neighborhood Hits	12
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

AKT2_MOUSE
NC score	0.024244 (rank : 106)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	75	Target Neighborhood Hits	875	Shared Neighborhood Hits	26
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_HUMAN
NC score	0.024084 (rank : 107)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	75	Target Neighborhood Hits	878	Shared Neighborhood Hits	28
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT1_HUMAN
NC score	0.023854 (rank : 108)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	75	Target Neighborhood Hits	885	Shared Neighborhood Hits	30
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
NC score	0.023821 (rank : 109)	θ value	0.365318 (rank : 39)
Query Neighborhood Hits	75	Target Neighborhood Hits	878	Shared Neighborhood Hits	30
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

NIPBL_HUMAN
NC score	0.022190 (rank : 110)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	75	Target Neighborhood Hits	1311	Shared Neighborhood Hits	16
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

AKT3_MOUSE
NC score	0.020260 (rank : 111)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	75	Target Neighborhood Hits	872	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AKT3_HUMAN
NC score	0.020259 (rank : 112)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	75	Target Neighborhood Hits	872	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

UBP53_MOUSE
NC score	0.019981 (rank : 113)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	75	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

CN145_HUMAN
NC score	0.019261 (rank : 114)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	75	Target Neighborhood Hits	1196	Shared Neighborhood Hits	21
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CTRO_MOUSE
NC score	0.016740 (rank : 115)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	75	Target Neighborhood Hits	2344	Shared Neighborhood Hits	32
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

RABE1_MOUSE
NC score	0.016697 (rank : 116)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	75	Target Neighborhood Hits	1105	Shared Neighborhood Hits	18
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

SRPK2_HUMAN
NC score	0.016313 (rank : 117)	θ value	1.06291 (rank : 45)
Query Neighborhood Hits	75	Target Neighborhood Hits	664	Shared Neighborhood Hits	10
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

CTRO_HUMAN
NC score	0.016310 (rank : 118)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	75	Target Neighborhood Hits	2092	Shared Neighborhood Hits	31
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

SVIL_HUMAN
NC score	0.016260 (rank : 119)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	75	Target Neighborhood Hits	232	Shared Neighborhood Hits	4
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

SRPK2_MOUSE
NC score	0.016098 (rank : 120)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	75	Target Neighborhood Hits	765	Shared Neighborhood Hits	12
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

RABE1_HUMAN
NC score	0.015957 (rank : 121)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	75	Target Neighborhood Hits	1104	Shared Neighborhood Hits	15
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

COG3_MOUSE
NC score	0.015779 (rank : 122)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	75	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CI04	Gene names	Cog3
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 3.

CEBPZ_HUMAN
NC score	0.015660 (rank : 123)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	75	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q03701, Q8NE75	Gene names	CEBPZ, CBF2
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

SEPN1_HUMAN
NC score	0.014101 (rank : 124)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	75	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZV5, Q6PI70, Q969F6, Q9NUI6	Gene names	SEPN1, SELN
Domain Architecture	No domain graphic available
Description	Selenoprotein N precursor.

STK23_MOUSE
NC score	0.010878 (rank : 125)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	75	Target Neighborhood Hits	572	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

UACA_MOUSE
NC score	0.008712 (rank : 126)	θ value	2.36792 (rank : 55)
Query Neighborhood Hits	75	Target Neighborhood Hits	1620	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

SYNJ2_MOUSE
NC score	0.006788 (rank : 127)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	75	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

PTN22_HUMAN
NC score	0.001952 (rank : 128)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

CSPG2_MOUSE
NC score	0.000993 (rank : 129)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	75	Target Neighborhood Hits	711	Shared Neighborhood Hits	5
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

PRRX1_MOUSE
NC score	0.000973 (rank : 130)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	75	Target Neighborhood Hits	346	Shared Neighborhood Hits	2
SwissProt Accessions	P63013, P43271, Q02810	Gene names	Prrx1, Pmx, Pmx1
Domain Architecture	No domain graphic available
Description	Paired mesoderm homeobox protein 1 (PRX-1) (Paired-related homeobox protein 1) (Homeobox protein mHox) (Homeobox protein K-2).