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Network neighborhood for query Sequence : FGD5_HUMAN

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FGD5_HUMAN
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD5_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	235
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	0 (rank : 2)	NC score	0.978701 (rank : 2)
Query Neighborhood Hits	235	Target Neighborhood Hits	170	Shared Neighborhood Hits	122
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_HUMAN
θ value	9.24197e-138 (rank : 3)	NC score	0.906746 (rank : 3)
Query Neighborhood Hits	235	Target Neighborhood Hits	237	Shared Neighborhood Hits	116
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	4.29305e-135 (rank : 4)	NC score	0.902402 (rank : 4)
Query Neighborhood Hits	235	Target Neighborhood Hits	282	Shared Neighborhood Hits	117
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD4_HUMAN
θ value	4.84666e-62 (rank : 5)	NC score	0.830400 (rank : 5)
Query Neighborhood Hits	235	Target Neighborhood Hits	219	Shared Neighborhood Hits	106
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	5.92465e-60 (rank : 6)	NC score	0.828046 (rank : 7)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	106
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
θ value	3.36421e-55 (rank : 7)	NC score	0.827711 (rank : 8)
Query Neighborhood Hits	235	Target Neighborhood Hits	367	Shared Neighborhood Hits	112
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	8.28633e-54 (rank : 8)	NC score	0.826324 (rank : 10)
Query Neighborhood Hits	235	Target Neighborhood Hits	387	Shared Neighborhood Hits	114
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	2.75849e-49 (rank : 9)	NC score	0.829453 (rank : 6)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	99
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	4.122e-45 (rank : 10)	NC score	0.826730 (rank : 9)
Query Neighborhood Hits	235	Target Neighborhood Hits	163	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	1.05066e-40 (rank : 11)	NC score	0.799008 (rank : 11)
Query Neighborhood Hits	235	Target Neighborhood Hits	249	Shared Neighborhood Hits	99
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	3.05695e-40 (rank : 12)	NC score	0.785498 (rank : 12)
Query Neighborhood Hits	235	Target Neighborhood Hits	257	Shared Neighborhood Hits	106
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FARP2_MOUSE
θ value	8.91499e-32 (rank : 13)	NC score	0.501109 (rank : 27)
Query Neighborhood Hits	235	Target Neighborhood Hits	209	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	5.77852e-31 (rank : 14)	NC score	0.499008 (rank : 28)
Query Neighborhood Hits	235	Target Neighborhood Hits	240	Shared Neighborhood Hits	72
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
θ value	1.33217e-27 (rank : 15)	NC score	0.475960 (rank : 29)
Query Neighborhood Hits	235	Target Neighborhood Hits	241	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHF1_HUMAN
θ value	5.07402e-19 (rank : 16)	NC score	0.718762 (rank : 13)
Query Neighborhood Hits	235	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	6.62687e-19 (rank : 17)	NC score	0.716356 (rank : 14)
Query Neighborhood Hits	235	Target Neighborhood Hits	80	Shared Neighborhood Hits	57
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHG1_HUMAN
θ value	7.58209e-15 (rank : 18)	NC score	0.504169 (rank : 26)
Query Neighborhood Hits	235	Target Neighborhood Hits	174	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHF2_HUMAN
θ value	1.86753e-13 (rank : 19)	NC score	0.706053 (rank : 15)
Query Neighborhood Hits	235	Target Neighborhood Hits	75	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	1.86753e-13 (rank : 20)	NC score	0.705731 (rank : 16)
Query Neighborhood Hits	235	Target Neighborhood Hits	77	Shared Neighborhood Hits	57
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ZFY16_HUMAN
θ value	2.43908e-13 (rank : 21)	NC score	0.539289 (rank : 21)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	2.0648e-12 (rank : 22)	NC score	0.547509 (rank : 19)
Query Neighborhood Hits	235	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ECT2_MOUSE
θ value	3.52202e-12 (rank : 23)	NC score	0.535187 (rank : 23)
Query Neighborhood Hits	235	Target Neighborhood Hits	98	Shared Neighborhood Hits	52
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
θ value	7.84624e-12 (rank : 24)	NC score	0.511707 (rank : 25)
Query Neighborhood Hits	235	Target Neighborhood Hits	177	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_HUMAN
θ value	1.74796e-11 (rank : 25)	NC score	0.525172 (rank : 24)
Query Neighborhood Hits	235	Target Neighborhood Hits	98	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_HUMAN
θ value	1.133e-10 (rank : 26)	NC score	0.453093 (rank : 31)
Query Neighborhood Hits	235	Target Neighborhood Hits	187	Shared Neighborhood Hits	49
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ZFYV9_HUMAN
θ value	1.133e-10 (rank : 27)	NC score	0.553273 (rank : 18)
Query Neighborhood Hits	235	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

DUET_HUMAN
θ value	2.52405e-10 (rank : 28)	NC score	0.162131 (rank : 117)
Query Neighborhood Hits	235	Target Neighborhood Hits	1220	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHGA_MOUSE
θ value	1.25267e-09 (rank : 29)	NC score	0.455428 (rank : 30)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	50
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

EEA1_MOUSE
θ value	3.64472e-09 (rank : 30)	NC score	0.200535 (rank : 107)
Query Neighborhood Hits	235	Target Neighborhood Hits	1637	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

TRIO_HUMAN
θ value	3.64472e-09 (rank : 31)	NC score	0.159320 (rank : 118)
Query Neighborhood Hits	235	Target Neighborhood Hits	1580	Shared Neighborhood Hits	76
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

EEA1_HUMAN
θ value	6.21693e-09 (rank : 32)	NC score	0.185996 (rank : 113)
Query Neighborhood Hits	235	Target Neighborhood Hits	1796	Shared Neighborhood Hits	92
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

HAPIP_HUMAN
θ value	8.97725e-08 (rank : 33)	NC score	0.394774 (rank : 40)
Query Neighborhood Hits	235	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HGS_MOUSE
θ value	1.17247e-07 (rank : 34)	NC score	0.413158 (rank : 36)
Query Neighborhood Hits	235	Target Neighborhood Hits	589	Shared Neighborhood Hits	64
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

WDFY3_MOUSE
θ value	1.17247e-07 (rank : 35)	NC score	0.313301 (rank : 64)
Query Neighborhood Hits	235	Target Neighborhood Hits	332	Shared Neighborhood Hits	64
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ZFY28_HUMAN
θ value	1.17247e-07 (rank : 36)	NC score	0.553620 (rank : 17)
Query Neighborhood Hits	235	Target Neighborhood Hits	152	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

WDFY3_HUMAN
θ value	1.99992e-07 (rank : 37)	NC score	0.312547 (rank : 65)
Query Neighborhood Hits	235	Target Neighborhood Hits	348	Shared Neighborhood Hits	63
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

HGS_HUMAN
θ value	5.81887e-07 (rank : 38)	NC score	0.411334 (rank : 37)
Query Neighborhood Hits	235	Target Neighborhood Hits	517	Shared Neighborhood Hits	59
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

PKHA6_HUMAN
θ value	7.59969e-07 (rank : 39)	NC score	0.269463 (rank : 80)
Query Neighborhood Hits	235	Target Neighborhood Hits	556	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RUFY2_MOUSE
θ value	7.59969e-07 (rank : 40)	NC score	0.301253 (rank : 69)
Query Neighborhood Hits	235	Target Neighborhood Hits	820	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

ANFY1_MOUSE
θ value	9.92553e-07 (rank : 41)	NC score	0.207259 (rank : 104)
Query Neighborhood Hits	235	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

RUFY2_HUMAN
θ value	9.92553e-07 (rank : 42)	NC score	0.244782 (rank : 89)
Query Neighborhood Hits	235	Target Neighborhood Hits	1208	Shared Neighborhood Hits	80
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

ABR_HUMAN
θ value	1.29631e-06 (rank : 43)	NC score	0.329672 (rank : 59)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	48
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ANFY1_HUMAN
θ value	1.29631e-06 (rank : 44)	NC score	0.206909 (rank : 105)
Query Neighborhood Hits	235	Target Neighborhood Hits	480	Shared Neighborhood Hits	55
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ARHG5_HUMAN
θ value	1.29631e-06 (rank : 45)	NC score	0.441391 (rank : 32)
Query Neighborhood Hits	235	Target Neighborhood Hits	172	Shared Neighborhood Hits	51
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

PKHA6_MOUSE
θ value	1.29631e-06 (rank : 46)	NC score	0.263237 (rank : 82)
Query Neighborhood Hits	235	Target Neighborhood Hits	591	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARHGG_HUMAN
θ value	1.69304e-06 (rank : 47)	NC score	0.423543 (rank : 33)
Query Neighborhood Hits	235	Target Neighborhood Hits	129	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

OBSCN_HUMAN
θ value	1.69304e-06 (rank : 48)	NC score	0.082596 (rank : 131)
Query Neighborhood Hits	235	Target Neighborhood Hits	1931	Shared Neighborhood Hits	53
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ZFYV1_HUMAN
θ value	1.69304e-06 (rank : 49)	NC score	0.420186 (rank : 34)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

RUFY1_MOUSE
θ value	2.88788e-06 (rank : 50)	NC score	0.298046 (rank : 71)
Query Neighborhood Hits	235	Target Neighborhood Hits	765	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

ZFYV1_MOUSE
θ value	3.77169e-06 (rank : 51)	NC score	0.415563 (rank : 35)
Query Neighborhood Hits	235	Target Neighborhood Hits	153	Shared Neighborhood Hits	55
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

BCR_HUMAN
θ value	4.92598e-06 (rank : 52)	NC score	0.331097 (rank : 57)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	50
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ZFY21_HUMAN
θ value	6.43352e-06 (rank : 53)	NC score	0.537228 (rank : 22)
Query Neighborhood Hits	235	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ARHG9_HUMAN
θ value	8.40245e-06 (rank : 54)	NC score	0.379192 (rank : 49)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	8.40245e-06 (rank : 55)	NC score	0.377242 (rank : 50)
Query Neighborhood Hits	235	Target Neighborhood Hits	234	Shared Neighborhood Hits	50
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

RUFY1_HUMAN
θ value	8.40245e-06 (rank : 56)	NC score	0.291927 (rank : 73)
Query Neighborhood Hits	235	Target Neighborhood Hits	848	Shared Neighborhood Hits	73
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

ZFY21_MOUSE
θ value	8.40245e-06 (rank : 57)	NC score	0.541598 (rank : 20)
Query Neighborhood Hits	235	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FYCO1_HUMAN
θ value	1.09739e-05 (rank : 58)	NC score	0.214193 (rank : 103)
Query Neighborhood Hits	235	Target Neighborhood Hits	1149	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

VAV_HUMAN
θ value	1.09739e-05 (rank : 59)	NC score	0.252023 (rank : 86)
Query Neighborhood Hits	235	Target Neighborhood Hits	452	Shared Neighborhood Hits	53
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ITSN2_HUMAN
θ value	1.43324e-05 (rank : 60)	NC score	0.254807 (rank : 85)
Query Neighborhood Hits	235	Target Neighborhood Hits	1173	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHGF_HUMAN
θ value	3.19293e-05 (rank : 61)	NC score	0.388758 (rank : 44)
Query Neighborhood Hits	235	Target Neighborhood Hits	214	Shared Neighborhood Hits	54
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_MOUSE
θ value	3.19293e-05 (rank : 62)	NC score	0.403848 (rank : 38)
Query Neighborhood Hits	235	Target Neighborhood Hits	152	Shared Neighborhood Hits	49
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ITSN2_MOUSE
θ value	3.19293e-05 (rank : 63)	NC score	0.248443 (rank : 87)
Query Neighborhood Hits	235	Target Neighborhood Hits	1371	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

WDFY1_HUMAN
θ value	5.44631e-05 (rank : 64)	NC score	0.310117 (rank : 68)
Query Neighborhood Hits	235	Target Neighborhood Hits	305	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ARHG2_MOUSE
θ value	7.1131e-05 (rank : 65)	NC score	0.374571 (rank : 51)
Query Neighborhood Hits	235	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGB_HUMAN
θ value	0.000121331 (rank : 66)	NC score	0.320765 (rank : 60)
Query Neighborhood Hits	235	Target Neighborhood Hits	375	Shared Neighborhood Hits	52
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FYCO1_MOUSE
θ value	0.000121331 (rank : 67)	NC score	0.195088 (rank : 111)
Query Neighborhood Hits	235	Target Neighborhood Hits	1059	Shared Neighborhood Hits	76
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

RASA2_MOUSE
θ value	0.000121331 (rank : 68)	NC score	0.086977 (rank : 127)
Query Neighborhood Hits	235	Target Neighborhood Hits	159	Shared Neighborhood Hits	24
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

MTMR3_HUMAN
θ value	0.000270298 (rank : 69)	NC score	0.287148 (rank : 77)
Query Neighborhood Hits	235	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RBNS5_HUMAN
θ value	0.00035302 (rank : 70)	NC score	0.392588 (rank : 42)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	0.00035302 (rank : 71)	NC score	0.387170 (rank : 45)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ARHG1_HUMAN
θ value	0.00102713 (rank : 72)	NC score	0.337640 (rank : 56)
Query Neighborhood Hits	235	Target Neighborhood Hits	176	Shared Neighborhood Hits	47
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

FYV1_HUMAN
θ value	0.00102713 (rank : 73)	NC score	0.345711 (rank : 53)
Query Neighborhood Hits	235	Target Neighborhood Hits	217	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	0.00102713 (rank : 74)	NC score	0.343016 (rank : 54)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

CNKR2_HUMAN
θ value	0.00175202 (rank : 75)	NC score	0.156840 (rank : 120)
Query Neighborhood Hits	235	Target Neighborhood Hits	197	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.00175202 (rank : 76)	NC score	0.157230 (rank : 119)
Query Neighborhood Hits	235	Target Neighborhood Hits	197	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHA5_HUMAN
θ value	0.00228821 (rank : 77)	NC score	0.198753 (rank : 109)
Query Neighborhood Hits	235	Target Neighborhood Hits	455	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

WDFY2_HUMAN
θ value	0.00228821 (rank : 78)	NC score	0.281829 (rank : 79)
Query Neighborhood Hits	235	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	0.00228821 (rank : 79)	NC score	0.283855 (rank : 78)
Query Neighborhood Hits	235	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

RASA2_HUMAN
θ value	0.00298849 (rank : 80)	NC score	0.074685 (rank : 139)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	22
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

ARHG1_MOUSE
θ value	0.00390308 (rank : 81)	NC score	0.330456 (rank : 58)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	51
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

PKHA4_HUMAN
θ value	0.00390308 (rank : 82)	NC score	0.195380 (rank : 110)
Query Neighborhood Hits	235	Target Neighborhood Hits	283	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	0.00390308 (rank : 83)	NC score	0.199357 (rank : 108)
Query Neighborhood Hits	235	Target Neighborhood Hits	202	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

NACAM_MOUSE
θ value	0.00869519 (rank : 84)	NC score	0.039922 (rank : 194)
Query Neighborhood Hits	235	Target Neighborhood Hits	1866	Shared Neighborhood Hits	52
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PKHG4_HUMAN
θ value	0.00869519 (rank : 85)	NC score	0.379495 (rank : 48)
Query Neighborhood Hits	235	Target Neighborhood Hits	200	Shared Neighborhood Hits	42
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

VAV2_MOUSE
θ value	0.0113563 (rank : 86)	NC score	0.234336 (rank : 92)
Query Neighborhood Hits	235	Target Neighborhood Hits	456	Shared Neighborhood Hits	56
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

MCF2_HUMAN
θ value	0.0148317 (rank : 87)	NC score	0.400920 (rank : 39)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

SOS1_HUMAN
θ value	0.0193708 (rank : 88)	NC score	0.185871 (rank : 114)
Query Neighborhood Hits	235	Target Neighborhood Hits	274	Shared Neighborhood Hits	36
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	0.0252991 (rank : 89)	NC score	0.171729 (rank : 116)
Query Neighborhood Hits	235	Target Neighborhood Hits	281	Shared Neighborhood Hits	34
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TGON2_HUMAN
θ value	0.0252991 (rank : 90)	NC score	0.037960 (rank : 197)
Query Neighborhood Hits	235	Target Neighborhood Hits	1037	Shared Neighborhood Hits	45
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ARHGC_HUMAN
θ value	0.0431538 (rank : 91)	NC score	0.296991 (rank : 72)
Query Neighborhood Hits	235	Target Neighborhood Hits	351	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GMEB1_MOUSE
θ value	0.0563607 (rank : 92)	NC score	0.045978 (rank : 191)
Query Neighborhood Hits	235	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JL60	Gene names	Gmeb1
Domain Architecture
Description	Glucocorticoid modulatory element-binding protein 1 (GMEB-1).

LBC_HUMAN
θ value	0.0563607 (rank : 93)	NC score	0.310361 (rank : 67)
Query Neighborhood Hits	235	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

SYNE2_HUMAN
θ value	0.0563607 (rank : 94)	NC score	0.038703 (rank : 196)
Query Neighborhood Hits	235	Target Neighborhood Hits	1323	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

GMEB1_HUMAN
θ value	0.0736092 (rank : 95)	NC score	0.047476 (rank : 189)
Query Neighborhood Hits	235	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y692, Q9NWH1, Q9UKD0	Gene names	GMEB1
Domain Architecture
Description	Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (Parvovirus initiation factor p96) (PIF p96) (DNA-binding protein p96PIF).

MCF2L_MOUSE
θ value	0.0736092 (rank : 96)	NC score	0.368354 (rank : 52)
Query Neighborhood Hits	235	Target Neighborhood Hits	255	Shared Neighborhood Hits	57
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

OSBL9_HUMAN
θ value	0.0961366 (rank : 97)	NC score	0.087211 (rank : 126)
Query Neighborhood Hits	235	Target Neighborhood Hits	138	Shared Neighborhood Hits	32
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

RASA3_HUMAN
θ value	0.0961366 (rank : 98)	NC score	0.068668 (rank : 145)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

BRD8_MOUSE
θ value	0.125558 (rank : 99)	NC score	0.033649 (rank : 206)
Query Neighborhood Hits	235	Target Neighborhood Hits	422	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

ARHGC_MOUSE
θ value	0.163984 (rank : 100)	NC score	0.290847 (rank : 75)
Query Neighborhood Hits	235	Target Neighborhood Hits	344	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BSCL2_HUMAN
θ value	0.163984 (rank : 101)	NC score	0.035825 (rank : 202)
Query Neighborhood Hits	235	Target Neighborhood Hits	148	Shared Neighborhood Hits	11
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

TXLNB_HUMAN
θ value	0.163984 (rank : 102)	NC score	0.030403 (rank : 210)
Query Neighborhood Hits	235	Target Neighborhood Hits	912	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

ZFY19_HUMAN
θ value	0.163984 (rank : 103)	NC score	0.338813 (rank : 55)
Query Neighborhood Hits	235	Target Neighborhood Hits	206	Shared Neighborhood Hits	54
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

CNKR1_HUMAN
θ value	0.21417 (rank : 104)	NC score	0.152454 (rank : 121)
Query Neighborhood Hits	235	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

LEO1_HUMAN
θ value	0.21417 (rank : 105)	NC score	0.024334 (rank : 222)
Query Neighborhood Hits	235	Target Neighborhood Hits	958	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

CTDP1_HUMAN
θ value	0.279714 (rank : 106)	NC score	0.037567 (rank : 199)
Query Neighborhood Hits	235	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

GON4L_MOUSE
θ value	0.279714 (rank : 107)	NC score	0.035038 (rank : 204)
Query Neighborhood Hits	235	Target Neighborhood Hits	455	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

TAU_HUMAN
θ value	0.279714 (rank : 108)	NC score	0.022375 (rank : 226)
Query Neighborhood Hits	235	Target Neighborhood Hits	448	Shared Neighborhood Hits	18
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TCAL5_HUMAN
θ value	0.279714 (rank : 109)	NC score	0.019604 (rank : 236)
Query Neighborhood Hits	235	Target Neighborhood Hits	806	Shared Neighborhood Hits	33
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

GOGA3_MOUSE
θ value	0.365318 (rank : 110)	NC score	0.049144 (rank : 188)
Query Neighborhood Hits	235	Target Neighborhood Hits	1437	Shared Neighborhood Hits	45
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

RASA3_MOUSE
θ value	0.365318 (rank : 111)	NC score	0.066661 (rank : 148)
Query Neighborhood Hits	235	Target Neighborhood Hits	144	Shared Neighborhood Hits	28
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

ZFY27_HUMAN
θ value	0.47712 (rank : 112)	NC score	0.223913 (rank : 99)
Query Neighborhood Hits	235	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
θ value	0.47712 (rank : 113)	NC score	0.229727 (rank : 97)
Query Neighborhood Hits	235	Target Neighborhood Hits	53	Shared Neighborhood Hits	45
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZN690_HUMAN
θ value	0.47712 (rank : 114)	NC score	-0.001370 (rank : 295)
Query Neighborhood Hits	235	Target Neighborhood Hits	777	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IWY8, Q32M75, Q32M76, Q8NA40	Gene names	ZNF690
Domain Architecture	No domain graphic available
Description	Zinc finger protein 690.

CAPON_MOUSE
θ value	0.62314 (rank : 115)	NC score	0.030341 (rank : 211)
Query Neighborhood Hits	235	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CIC_MOUSE
θ value	0.62314 (rank : 116)	NC score	0.022636 (rank : 225)
Query Neighborhood Hits	235	Target Neighborhood Hits	742	Shared Neighborhood Hits	23
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

IWS1_MOUSE
θ value	0.62314 (rank : 117)	NC score	0.026425 (rank : 219)
Query Neighborhood Hits	235	Target Neighborhood Hits	1258	Shared Neighborhood Hits	51
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

OGFR_HUMAN
θ value	0.62314 (rank : 118)	NC score	0.037946 (rank : 198)
Query Neighborhood Hits	235	Target Neighborhood Hits	1582	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

OXR1_MOUSE
θ value	0.62314 (rank : 119)	NC score	0.028132 (rank : 215)
Query Neighborhood Hits	235	Target Neighborhood Hits	516	Shared Neighborhood Hits	25
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

ALO17_HUMAN
θ value	0.813845 (rank : 120)	NC score	0.025367 (rank : 221)
Query Neighborhood Hits	235	Target Neighborhood Hits	317	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCF4, Q69YK7, Q8IWF4, Q8IZX1, Q8IZX2, Q8N406	Gene names	KIAA1618, ALO17
Domain Architecture	No domain graphic available
Description	Protein ALO17 (ALK lymphoma oligomerization partner on chromosome 17).

CYH3_HUMAN
θ value	0.813845 (rank : 121)	NC score	0.078619 (rank : 134)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
θ value	0.813845 (rank : 122)	NC score	0.092224 (rank : 124)
Query Neighborhood Hits	235	Target Neighborhood Hits	148	Shared Neighborhood Hits	47
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

PPCT_MOUSE
θ value	0.813845 (rank : 123)	NC score	0.026014 (rank : 220)
Query Neighborhood Hits	235	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P53808, Q9QZX0, Q9R058	Gene names	Pctp, Stard2
Domain Architecture
Description	Phosphatidylcholine transfer protein (PC-TP) (StAR-related lipid transfer protein 2) (StARD2) (START domain-containing protein 2).

TCF8_HUMAN
θ value	0.813845 (rank : 124)	NC score	0.004753 (rank : 285)
Query Neighborhood Hits	235	Target Neighborhood Hits	1057	Shared Neighborhood Hits	48
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

ITF2_HUMAN
θ value	1.06291 (rank : 125)	NC score	0.017343 (rank : 242)
Query Neighborhood Hits	235	Target Neighborhood Hits	168	Shared Neighborhood Hits	9
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

JADE1_HUMAN
θ value	1.06291 (rank : 126)	NC score	0.009284 (rank : 274)
Query Neighborhood Hits	235	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q6IE81, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692	Gene names	PHF17, JADE1, KIAA1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

MYCB2_MOUSE
θ value	1.06291 (rank : 127)	NC score	0.021372 (rank : 229)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

ZCH13_HUMAN
θ value	1.06291 (rank : 128)	NC score	0.050255 (rank : 187)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WW36	Gene names	ZCCHC13
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 13.

ANR26_MOUSE
θ value	1.38821 (rank : 129)	NC score	0.030277 (rank : 212)
Query Neighborhood Hits	235	Target Neighborhood Hits	1554	Shared Neighborhood Hits	39
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CYH1_HUMAN
θ value	1.38821 (rank : 130)	NC score	0.076601 (rank : 137)
Query Neighborhood Hits	235	Target Neighborhood Hits	184	Shared Neighborhood Hits	55
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	1.38821 (rank : 131)	NC score	0.073725 (rank : 140)
Query Neighborhood Hits	235	Target Neighborhood Hits	176	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

MYCN_MOUSE
θ value	1.38821 (rank : 132)	NC score	0.015714 (rank : 255)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	7
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

RASA1_HUMAN
θ value	1.38821 (rank : 133)	NC score	0.037260 (rank : 200)
Query Neighborhood Hits	235	Target Neighborhood Hits	258	Shared Neighborhood Hits	31
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

TACC1_MOUSE
θ value	1.38821 (rank : 134)	NC score	0.034584 (rank : 205)
Query Neighborhood Hits	235	Target Neighborhood Hits	667	Shared Neighborhood Hits	34
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

ZDHC1_MOUSE
θ value	1.38821 (rank : 135)	NC score	0.021999 (rank : 227)
Query Neighborhood Hits	235	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R0N9, Q8BJ24	Gene names	Zdhhc1
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1).

ZN638_HUMAN
θ value	1.38821 (rank : 136)	NC score	0.023549 (rank : 224)
Query Neighborhood Hits	235	Target Neighborhood Hits	343	Shared Neighborhood Hits	17
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

CIC_HUMAN
θ value	1.81305 (rank : 137)	NC score	0.026643 (rank : 218)
Query Neighborhood Hits	235	Target Neighborhood Hits	992	Shared Neighborhood Hits	33
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

LEO1_MOUSE
θ value	1.81305 (rank : 138)	NC score	0.017519 (rank : 241)
Query Neighborhood Hits	235	Target Neighborhood Hits	946	Shared Neighborhood Hits	27
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

NBEA_MOUSE
θ value	1.81305 (rank : 139)	NC score	0.035504 (rank : 203)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

OSBP1_HUMAN
θ value	1.81305 (rank : 140)	NC score	0.031236 (rank : 208)
Query Neighborhood Hits	235	Target Neighborhood Hits	180	Shared Neighborhood Hits	34
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

TCF17_MOUSE
θ value	1.81305 (rank : 141)	NC score	-0.001984 (rank : 297)
Query Neighborhood Hits	235	Target Neighborhood Hits	786	Shared Neighborhood Hits	18
SwissProt Accessions	Q61751	Gene names	Znf354a, Kid1, Tcf17, Zfp354a
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally- regulated protein 1).

TLE4_MOUSE
θ value	1.81305 (rank : 142)	NC score	0.015597 (rank : 257)
Query Neighborhood Hits	235	Target Neighborhood Hits	482	Shared Neighborhood Hits	15
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

ZN486_HUMAN
θ value	1.81305 (rank : 143)	NC score	0.002251 (rank : 291)
Query Neighborhood Hits	235	Target Neighborhood Hits	645	Shared Neighborhood Hits	13
SwissProt Accessions	Q96H40	Gene names	ZNF486, KRBO2
Domain Architecture	No domain graphic available
Description	Zinc finger protein 486.

CMGA_HUMAN
θ value	2.36792 (rank : 144)	NC score	0.027690 (rank : 216)
Query Neighborhood Hits	235	Target Neighborhood Hits	238	Shared Neighborhood Hits	18
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

DGKH_HUMAN
θ value	2.36792 (rank : 145)	NC score	0.066823 (rank : 147)
Query Neighborhood Hits	235	Target Neighborhood Hits	255	Shared Neighborhood Hits	45
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

GNRP_MOUSE
θ value	2.36792 (rank : 146)	NC score	0.320724 (rank : 61)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	63
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

PLEK2_MOUSE
θ value	2.36792 (rank : 147)	NC score	0.044317 (rank : 192)
Query Neighborhood Hits	235	Target Neighborhood Hits	96	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PP4R1_MOUSE
θ value	2.36792 (rank : 148)	NC score	0.013090 (rank : 265)
Query Neighborhood Hits	235	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

RFC1_MOUSE
θ value	2.36792 (rank : 149)	NC score	0.020129 (rank : 231)
Query Neighborhood Hits	235	Target Neighborhood Hits	290	Shared Neighborhood Hits	20
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

TCF25_HUMAN
θ value	2.36792 (rank : 150)	NC score	0.016162 (rank : 250)
Query Neighborhood Hits	235	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQ70, Q2MK75, Q9UPV3	Gene names	TCF25, KIAA1049, NULP1
Domain Architecture
Description	Transcription factor 25 (Nuclear localized protein 1).

TEAD2_MOUSE
θ value	2.36792 (rank : 151)	NC score	0.008924 (rank : 276)
Query Neighborhood Hits	235	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P48301, Q62297	Gene names	Tead2, Etdf, Etf, Tef4
Domain Architecture
Description	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) (Embryonic TEA domain-containing factor) (ETF) (ETEF-1).

TLE4_HUMAN
θ value	2.36792 (rank : 152)	NC score	0.015169 (rank : 259)
Query Neighborhood Hits	235	Target Neighborhood Hits	477	Shared Neighborhood Hits	14
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

ZFY19_MOUSE
θ value	2.36792 (rank : 153)	NC score	0.317866 (rank : 62)
Query Neighborhood Hits	235	Target Neighborhood Hits	143	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

AHTF1_HUMAN
θ value	3.0926 (rank : 154)	NC score	0.021310 (rank : 230)
Query Neighborhood Hits	235	Target Neighborhood Hits	286	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WYP5, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6	Gene names	AHCTF1, ELYS, TMBS62
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

ATBF1_MOUSE
θ value	3.0926 (rank : 155)	NC score	0.008770 (rank : 277)
Query Neighborhood Hits	235	Target Neighborhood Hits	1841	Shared Neighborhood Hits	51
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

BTBDC_HUMAN
θ value	3.0926 (rank : 156)	NC score	0.019823 (rank : 234)
Query Neighborhood Hits	235	Target Neighborhood Hits	248	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

ERIC1_HUMAN
θ value	3.0926 (rank : 157)	NC score	0.029491 (rank : 213)
Query Neighborhood Hits	235	Target Neighborhood Hits	364	Shared Neighborhood Hits	20
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

ITF2_MOUSE
θ value	3.0926 (rank : 158)	NC score	0.015310 (rank : 258)
Query Neighborhood Hits	235	Target Neighborhood Hits	154	Shared Neighborhood Hits	8
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

MYH8_MOUSE
θ value	3.0926 (rank : 159)	NC score	0.020092 (rank : 232)
Query Neighborhood Hits	235	Target Neighborhood Hits	1600	Shared Neighborhood Hits	44
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

PCDH7_HUMAN
θ value	3.0926 (rank : 160)	NC score	-0.000298 (rank : 294)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	O60245, O60246, O60247	Gene names	PCDH7, BHPCDH
Domain Architecture
Description	Protocadherin-7 precursor (Brain-heart protocadherin) (BH-Pcdh).

PSD4_HUMAN
θ value	3.0926 (rank : 161)	NC score	0.037038 (rank : 201)
Query Neighborhood Hits	235	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

RFFL_HUMAN
θ value	3.0926 (rank : 162)	NC score	0.075547 (rank : 138)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RNF34_MOUSE
θ value	3.0926 (rank : 163)	NC score	0.081901 (rank : 132)
Query Neighborhood Hits	235	Target Neighborhood Hits	160	Shared Neighborhood Hits	40
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

SWP70_MOUSE
θ value	3.0926 (rank : 164)	NC score	0.083211 (rank : 130)
Query Neighborhood Hits	235	Target Neighborhood Hits	1097	Shared Neighborhood Hits	74
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TCF8_MOUSE
θ value	3.0926 (rank : 165)	NC score	0.002182 (rank : 293)
Query Neighborhood Hits	235	Target Neighborhood Hits	1067	Shared Neighborhood Hits	31
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ZN496_HUMAN
θ value	3.0926 (rank : 166)	NC score	-0.001932 (rank : 296)
Query Neighborhood Hits	235	Target Neighborhood Hits	743	Shared Neighborhood Hits	15
SwissProt Accessions	Q96IT1	Gene names	ZNF496
Domain Architecture	No domain graphic available
Description	Zinc finger protein 496.

BRD8_HUMAN
θ value	4.03905 (rank : 167)	NC score	0.019602 (rank : 237)
Query Neighborhood Hits	235	Target Neighborhood Hits	292	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

CGRE1_HUMAN
θ value	4.03905 (rank : 168)	NC score	0.011755 (rank : 268)
Query Neighborhood Hits	235	Target Neighborhood Hits	354	Shared Neighborhood Hits	13
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

DOCK9_HUMAN
θ value	4.03905 (rank : 169)	NC score	0.014626 (rank : 261)
Query Neighborhood Hits	235	Target Neighborhood Hits	82	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

GNRP_HUMAN
θ value	4.03905 (rank : 170)	NC score	0.301161 (rank : 70)
Query Neighborhood Hits	235	Target Neighborhood Hits	239	Shared Neighborhood Hits	67
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GOGA3_HUMAN
θ value	4.03905 (rank : 171)	NC score	0.039281 (rank : 195)
Query Neighborhood Hits	235	Target Neighborhood Hits	1317	Shared Neighborhood Hits	38
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GON4L_HUMAN
θ value	4.03905 (rank : 172)	NC score	0.026656 (rank : 217)
Query Neighborhood Hits	235	Target Neighborhood Hits	555	Shared Neighborhood Hits	29
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

RNF34_HUMAN
θ value	4.03905 (rank : 173)	NC score	0.076893 (rank : 136)
Query Neighborhood Hits	235	Target Neighborhood Hits	153	Shared Neighborhood Hits	35
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

SWP70_HUMAN
θ value	4.03905 (rank : 174)	NC score	0.084805 (rank : 128)
Query Neighborhood Hits	235	Target Neighborhood Hits	973	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TE2IP_HUMAN
θ value	4.03905 (rank : 175)	NC score	0.014308 (rank : 262)
Query Neighborhood Hits	235	Target Neighborhood Hits	75	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NYB0, Q8WYZ3, Q9NWR2	Gene names	TERF2IP, RAP1
Domain Architecture	No domain graphic available
Description	Telomeric repeat-binding factor 2-interacting protein 1 (TRF2- interacting telomeric protein Rap1) (hRap1).

UBP53_MOUSE
θ value	4.03905 (rank : 176)	NC score	0.011460 (rank : 269)
Query Neighborhood Hits	235	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

ZN273_HUMAN
θ value	4.03905 (rank : 177)	NC score	-0.003249 (rank : 299)
Query Neighborhood Hits	235	Target Neighborhood Hits	739	Shared Neighborhood Hits	15
SwissProt Accessions	Q14593, Q6P3V4	Gene names	ZNF273
Domain Architecture	No domain graphic available
Description	Zinc finger protein 273 (Zinc finger protein HZF9).

AKAP8_HUMAN
θ value	5.27518 (rank : 178)	NC score	0.010257 (rank : 272)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	O43823	Gene names	AKAP8, AKAP95
Domain Architecture
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

CCD41_MOUSE
θ value	5.27518 (rank : 179)	NC score	0.028875 (rank : 214)
Query Neighborhood Hits	235	Target Neighborhood Hits	1399	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CKAP2_MOUSE
θ value	5.27518 (rank : 180)	NC score	0.023552 (rank : 223)
Query Neighborhood Hits	235	Target Neighborhood Hits	63	Shared Neighborhood Hits	5
SwissProt Accessions	Q3V1H1, Q66LN2, Q8BSF0	Gene names	Ckap2
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2.

CN037_MOUSE
θ value	5.27518 (rank : 181)	NC score	0.019496 (rank : 238)
Query Neighborhood Hits	235	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BT18, Q8BFQ7, Q8R1Q5, Q9D6C5	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf37 homolog precursor.

SYTL1_MOUSE
θ value	5.27518 (rank : 182)	NC score	0.012771 (rank : 267)
Query Neighborhood Hits	235	Target Neighborhood Hits	314	Shared Neighborhood Hits	14
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

ZDHC1_HUMAN
θ value	5.27518 (rank : 183)	NC score	0.014644 (rank : 260)
Query Neighborhood Hits	235	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WTX9, O15461	Gene names	ZDHHC1, C16orf1, ZNF377
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) (DHHC- domain-containing cysteine-rich protein 1).

ZN215_HUMAN
θ value	5.27518 (rank : 184)	NC score	-0.002996 (rank : 298)
Query Neighborhood Hits	235	Target Neighborhood Hits	711	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UL58	Gene names	ZNF215, BAZ2
Domain Architecture
Description	Zinc finger protein 215 (BWSCR2-associated zinc-finger protein 2) (BAZ 2).

ZN319_MOUSE
θ value	5.27518 (rank : 185)	NC score	-0.003653 (rank : 300)
Query Neighborhood Hits	235	Target Neighborhood Hits	762	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ERR8	Gene names	Znf319, Zfp319
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

AMOL1_HUMAN
θ value	6.88961 (rank : 186)	NC score	0.019757 (rank : 235)
Query Neighborhood Hits	235	Target Neighborhood Hits	435	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

ANK1_HUMAN
θ value	6.88961 (rank : 187)	NC score	0.008428 (rank : 278)
Query Neighborhood Hits	235	Target Neighborhood Hits	416	Shared Neighborhood Hits	6
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ARHG7_HUMAN
θ value	6.88961 (rank : 188)	NC score	0.268978 (rank : 81)
Query Neighborhood Hits	235	Target Neighborhood Hits	347	Shared Neighborhood Hits	54
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	6.88961 (rank : 189)	NC score	0.243949 (rank : 90)
Query Neighborhood Hits	235	Target Neighborhood Hits	396	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

BNC2_HUMAN
θ value	6.88961 (rank : 190)	NC score	0.007013 (rank : 282)
Query Neighborhood Hits	235	Target Neighborhood Hits	439	Shared Neighborhood Hits	14
SwissProt Accessions	Q6ZN30, Q6T3A3, Q8NAR2, Q9H6J0, Q9NXV0	Gene names	BNC2
Domain Architecture	No domain graphic available
Description	Zinc finger protein basonuclin-2.

CAPS1_HUMAN
θ value	6.88961 (rank : 191)	NC score	0.016075 (rank : 251)
Query Neighborhood Hits	235	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULU8, Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2	Gene names	CADPS, CAPS, CAPS1, KIAA1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

CAPS1_MOUSE
θ value	6.88961 (rank : 192)	NC score	0.015811 (rank : 253)
Query Neighborhood Hits	235	Target Neighborhood Hits	93	Shared Neighborhood Hits	15
SwissProt Accessions	Q80TJ1, Q3TSP2, Q61374, Q6AXB4, Q6PGF0	Gene names	Cadps, Caps, Caps1, Kiaa1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

CYH2_HUMAN
θ value	6.88961 (rank : 193)	NC score	0.066436 (rank : 150)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	48
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	6.88961 (rank : 194)	NC score	0.066451 (rank : 149)
Query Neighborhood Hits	235	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

DGKD_HUMAN
θ value	6.88961 (rank : 195)	NC score	0.046863 (rank : 190)
Query Neighborhood Hits	235	Target Neighborhood Hits	231	Shared Neighborhood Hits	25
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

GAGE3_HUMAN
θ value	6.88961 (rank : 196)	NC score	0.016777 (rank : 244)
Query Neighborhood Hits	235	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13067	Gene names	GAGE3
Domain Architecture
Description	G antigen 3 (GAGE-3).

GAGE4_HUMAN
θ value	6.88961 (rank : 197)	NC score	0.016524 (rank : 248)
Query Neighborhood Hits	235	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13068, Q6NT33	Gene names	GAGE4
Domain Architecture
Description	G antigen 4 (GAGE-4).

GAGE5_HUMAN
θ value	6.88961 (rank : 198)	NC score	0.016570 (rank : 246)
Query Neighborhood Hits	235	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q13069, Q6FG72	Gene names	GAGE5
Domain Architecture
Description	G antigen 5 (GAGE-5).

GAGE6_HUMAN
θ value	6.88961 (rank : 199)	NC score	0.016537 (rank : 247)
Query Neighborhood Hits	235	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	Q13070	Gene names	GAGE6
Domain Architecture
Description	G antigen 6 (GAGE-6).

GAGE8_HUMAN
θ value	6.88961 (rank : 200)	NC score	0.017132 (rank : 243)
Query Neighborhood Hits	235	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UEU5, Q4V325	Gene names	GAGE8
Domain Architecture
Description	G antigen 8 (GAGE-8).

GRAM3_HUMAN
θ value	6.88961 (rank : 201)	NC score	0.009331 (rank : 273)
Query Neighborhood Hits	235	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q96HH9, Q9H753	Gene names	GRAMD3, NS3TP2
Domain Architecture	No domain graphic available
Description	GRAM domain-containing protein 3 (HCV NS3-transactivated protein 2).

MAGE1_HUMAN
θ value	6.88961 (rank : 202)	NC score	0.015798 (rank : 254)
Query Neighborhood Hits	235	Target Neighborhood Hits	1389	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MILK1_MOUSE
θ value	6.88961 (rank : 203)	NC score	0.016716 (rank : 245)
Query Neighborhood Hits	235	Target Neighborhood Hits	788	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MTMRD_HUMAN
θ value	6.88961 (rank : 204)	NC score	0.051241 (rank : 180)
Query Neighborhood Hits	235	Target Neighborhood Hits	135	Shared Neighborhood Hits	30
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

NASP_HUMAN
θ value	6.88961 (rank : 205)	NC score	0.021717 (rank : 228)
Query Neighborhood Hits	235	Target Neighborhood Hits	709	Shared Neighborhood Hits	37
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

PGCA_MOUSE
θ value	6.88961 (rank : 206)	NC score	0.002372 (rank : 290)
Query Neighborhood Hits	235	Target Neighborhood Hits	643	Shared Neighborhood Hits	15
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

REXO1_MOUSE
θ value	6.88961 (rank : 207)	NC score	0.013635 (rank : 263)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

RFFL_MOUSE
θ value	6.88961 (rank : 208)	NC score	0.083476 (rank : 129)
Query Neighborhood Hits	235	Target Neighborhood Hits	145	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RHG25_HUMAN
θ value	6.88961 (rank : 209)	NC score	0.053434 (rank : 177)
Query Neighborhood Hits	235	Target Neighborhood Hits	550	Shared Neighborhood Hits	56
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	6.88961 (rank : 210)	NC score	0.051187 (rank : 181)
Query Neighborhood Hits	235	Target Neighborhood Hits	492	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RKHD1_HUMAN
θ value	6.88961 (rank : 211)	NC score	0.019376 (rank : 239)
Query Neighborhood Hits	235	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

TOIP2_HUMAN
θ value	6.88961 (rank : 212)	NC score	0.010419 (rank : 271)
Query Neighborhood Hits	235	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFQ8	Gene names	TOR1AIP2, LULL1
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1).

ZFHX2_HUMAN
θ value	6.88961 (rank : 213)	NC score	0.002227 (rank : 292)
Query Neighborhood Hits	235	Target Neighborhood Hits	1178	Shared Neighborhood Hits	34
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

CAPS2_MOUSE
θ value	8.99809 (rank : 214)	NC score	0.019887 (rank : 233)
Query Neighborhood Hits	235	Target Neighborhood Hits	78	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BYR5, O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8K3K6	Gene names	Cadps2, Caps2
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

CD6_HUMAN
θ value	8.99809 (rank : 215)	NC score	0.003315 (rank : 288)
Query Neighborhood Hits	235	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

CEND2_HUMAN
θ value	8.99809 (rank : 216)	NC score	0.031246 (rank : 207)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

DOCK9_MOUSE
θ value	8.99809 (rank : 217)	NC score	0.013329 (rank : 264)
Query Neighborhood Hits	235	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

FA13C_HUMAN
θ value	8.99809 (rank : 218)	NC score	0.006918 (rank : 283)
Query Neighborhood Hits	235	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NE31, Q99787	Gene names	FAM13C1
Domain Architecture	No domain graphic available
Description	Protein FAM13C1.

GAGE2_HUMAN
θ value	8.99809 (rank : 219)	NC score	0.016220 (rank : 249)
Query Neighborhood Hits	235	Target Neighborhood Hits	50	Shared Neighborhood Hits	12
SwissProt Accessions	Q13066, Q4V322	Gene names	GAGE2
Domain Architecture	No domain graphic available
Description	G antigen 2 (GAGE-2).

GAGE7_HUMAN
θ value	8.99809 (rank : 220)	NC score	0.015673 (rank : 256)
Query Neighborhood Hits	235	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	O76087, Q4V324	Gene names	GAGE7B, GAGE7
Domain Architecture
Description	G antigen 7 (GAGE-7) (GAGE-7B) (GAGE-8) (AL4).

GRB14_HUMAN
θ value	8.99809 (rank : 221)	NC score	0.008932 (rank : 275)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	14
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

HAP1_MOUSE
θ value	8.99809 (rank : 222)	NC score	0.017970 (rank : 240)
Query Neighborhood Hits	235	Target Neighborhood Hits	388	Shared Neighborhood Hits	22
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

HCN4_HUMAN
θ value	8.99809 (rank : 223)	NC score	0.003637 (rank : 287)
Query Neighborhood Hits	235	Target Neighborhood Hits	303	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

K1849_MOUSE
θ value	8.99809 (rank : 224)	NC score	0.003743 (rank : 286)
Query Neighborhood Hits	235	Target Neighborhood Hits	335	Shared Neighborhood Hits	7
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MA2B2_MOUSE
θ value	8.99809 (rank : 225)	NC score	0.004822 (rank : 284)
Query Neighborhood Hits	235	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MAGC1_HUMAN
θ value	8.99809 (rank : 226)	NC score	0.008249 (rank : 279)
Query Neighborhood Hits	235	Target Neighborhood Hits	431	Shared Neighborhood Hits	22
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

NIPBL_HUMAN
θ value	8.99809 (rank : 227)	NC score	0.010978 (rank : 270)
Query Neighborhood Hits	235	Target Neighborhood Hits	1311	Shared Neighborhood Hits	41
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PLEK2_HUMAN
θ value	8.99809 (rank : 228)	NC score	0.042253 (rank : 193)
Query Neighborhood Hits	235	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PPCT_HUMAN
θ value	8.99809 (rank : 229)	NC score	0.015911 (rank : 252)
Query Neighborhood Hits	235	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKL6, Q9UIT3, Q9UKW7	Gene names	PCTP, STARD2
Domain Architecture
Description	Phosphatidylcholine transfer protein (PC-TP) (StAR-related lipid transfer protein 2) (StARD2) (START domain-containing protein 2).

PSD3_HUMAN
θ value	8.99809 (rank : 230)	NC score	0.031171 (rank : 209)
Query Neighborhood Hits	235	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

SPIN2_HUMAN
θ value	8.99809 (rank : 231)	NC score	0.007875 (rank : 281)
Query Neighborhood Hits	235	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BPZ2, Q7Z2M0	Gene names	SPIN2
Domain Architecture
Description	Spindlin-2 (Spindlin-like protein 2) (SPIN-2).

SPIN3_HUMAN
θ value	8.99809 (rank : 232)	NC score	0.007883 (rank : 280)
Query Neighborhood Hits	235	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q99865, O75650, Q6IPW2, Q9UJJ0	Gene names	SPIN3, DXF34
Domain Architecture
Description	Spindlin-3 (Spindlin-like protein 3) (SPIN-3) (Protein DXF34).

SUSD4_HUMAN
θ value	8.99809 (rank : 233)	NC score	0.003228 (rank : 289)
Query Neighborhood Hits	235	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q5VX71, Q6UX62, Q9BSR0, Q9NWG0	Gene names	SUSD4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

TCAL8_MOUSE
θ value	8.99809 (rank : 234)	NC score	0.012899 (rank : 266)
Query Neighborhood Hits	235	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CZY2, Q9CYP9	Gene names	Tceal8
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 8 (TCEA-like protein 8) (Transcription elongation factor S-II protein-like 8).

ZN596_HUMAN
θ value	8.99809 (rank : 235)	NC score	-0.003945 (rank : 301)
Query Neighborhood Hits	235	Target Neighborhood Hits	716	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TC21, O95015, Q8N9X0	Gene names	ZNF596
Domain Architecture	No domain graphic available
Description	Zinc finger protein 596.

3BP2_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.068252 (rank : 146)
Query Neighborhood Hits	235	Target Neighborhood Hits	296	Shared Neighborhood Hits	28
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.065708 (rank : 151)
Query Neighborhood Hits	235	Target Neighborhood Hits	142	Shared Neighborhood Hits	31
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

41_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.065538 (rank : 152)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	12
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.063901 (rank : 157)
Query Neighborhood Hits	235	Target Neighborhood Hits	184	Shared Neighborhood Hits	13
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ALS2_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.093914 (rank : 123)
Query Neighborhood Hits	235	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.107637 (rank : 122)
Query Neighborhood Hits	235	Target Neighborhood Hits	111	Shared Neighborhood Hits	20
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG2_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.289503 (rank : 76)
Query Neighborhood Hits	235	Target Neighborhood Hits	142	Shared Neighborhood Hits	44
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG3_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.259188 (rank : 83)
Query Neighborhood Hits	235	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.258984 (rank : 84)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	45
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.382127 (rank : 46)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.389027 (rank : 43)
Query Neighborhood Hits	235	Target Neighborhood Hits	185	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.206414 (rank : 106)
Query Neighborhood Hits	235	Target Neighborhood Hits	376	Shared Neighborhood Hits	47
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.185863 (rank : 115)
Query Neighborhood Hits	235	Target Neighborhood Hits	394	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG8_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.290860 (rank : 74)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.230770 (rank : 96)
Query Neighborhood Hits	235	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

C43BP_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.057377 (rank : 169)
Query Neighborhood Hits	235	Target Neighborhood Hits	87	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.056956 (rank : 171)
Query Neighborhood Hits	235	Target Neighborhood Hits	91	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CJ064_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.055717 (rank : 175)
Query Neighborhood Hits	235	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

CYH4_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.072461 (rank : 142)
Query Neighborhood Hits	235	Target Neighborhood Hits	135	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.078728 (rank : 133)
Query Neighborhood Hits	235	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DNMBP_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.221263 (rank : 100)
Query Neighborhood Hits	235	Target Neighborhood Hits	413	Shared Neighborhood Hits	57
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.229186 (rank : 98)
Query Neighborhood Hits	235	Target Neighborhood Hits	435	Shared Neighborhood Hits	53
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

E41L1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.061395 (rank : 165)
Query Neighborhood Hits	235	Target Neighborhood Hits	180	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.061573 (rank : 164)
Query Neighborhood Hits	235	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.062444 (rank : 162)
Query Neighborhood Hits	235	Target Neighborhood Hits	287	Shared Neighborhood Hits	13
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.063106 (rank : 158)
Query Neighborhood Hits	235	Target Neighborhood Hits	459	Shared Neighborhood Hits	20
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.064385 (rank : 155)
Query Neighborhood Hits	235	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.062770 (rank : 159)
Query Neighborhood Hits	235	Target Neighborhood Hits	250	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.064401 (rank : 154)
Query Neighborhood Hits	235	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LA_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.058411 (rank : 166)
Query Neighborhood Hits	235	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.057979 (rank : 167)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	6
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LB_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.064829 (rank : 153)
Query Neighborhood Hits	235	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.064183 (rank : 156)
Query Neighborhood Hits	235	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EZRI_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.050308 (rank : 186)
Query Neighborhood Hits	235	Target Neighborhood Hits	663	Shared Neighborhood Hits	25
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FRMD5_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.062305 (rank : 163)
Query Neighborhood Hits	235	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.062722 (rank : 160)
Query Neighborhood Hits	235	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

ITSN1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.232386 (rank : 94)
Query Neighborhood Hits	235	Target Neighborhood Hits	1757	Shared Neighborhood Hits	85
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.231306 (rank : 95)
Query Neighborhood Hits	235	Target Neighborhood Hits	1669	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MERL_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.050356 (rank : 185)
Query Neighborhood Hits	235	Target Neighborhood Hits	532	Shared Neighborhood Hits	20
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.050613 (rank : 183)
Query Neighborhood Hits	235	Target Neighborhood Hits	524	Shared Neighborhood Hits	20
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MOES_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.052164 (rank : 179)
Query Neighborhood Hits	235	Target Neighborhood Hits	892	Shared Neighborhood Hits	31
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.053378 (rank : 178)
Query Neighborhood Hits	235	Target Neighborhood Hits	923	Shared Neighborhood Hits	31
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYLIP_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.056126 (rank : 173)
Query Neighborhood Hits	235	Target Neighborhood Hits	162	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.056116 (rank : 174)
Query Neighborhood Hits	235	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NGEF_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.393108 (rank : 41)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.381555 (rank : 47)
Query Neighborhood Hits	235	Target Neighborhood Hits	228	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHA1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.057529 (rank : 168)
Query Neighborhood Hits	235	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.057139 (rank : 170)
Query Neighborhood Hits	235	Target Neighborhood Hits	120	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.077626 (rank : 135)
Query Neighborhood Hits	235	Target Neighborhood Hits	119	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.090624 (rank : 125)
Query Neighborhood Hits	235	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA3_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.056258 (rank : 172)
Query Neighborhood Hits	235	Target Neighborhood Hits	66	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.055010 (rank : 176)
Query Neighborhood Hits	235	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PLEK_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.071172 (rank : 144)
Query Neighborhood Hits	235	Target Neighborhood Hits	110	Shared Neighborhood Hits	37
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.062487 (rank : 161)
Query Neighborhood Hits	235	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RADI_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.050941 (rank : 182)
Query Neighborhood Hits	235	Target Neighborhood Hits	741	Shared Neighborhood Hits	23
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.050363 (rank : 184)
Query Neighborhood Hits	235	Target Neighborhood Hits	773	Shared Neighborhood Hits	25
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

RGNEF_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.215008 (rank : 102)
Query Neighborhood Hits	235	Target Neighborhood Hits	641	Shared Neighborhood Hits	57
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RUFY3_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.071640 (rank : 143)
Query Neighborhood Hits	235	Target Neighborhood Hits	594	Shared Neighborhood Hits	20
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.072798 (rank : 141)
Query Neighborhood Hits	235	Target Neighborhood Hits	579	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SOS2_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.188780 (rank : 112)
Query Neighborhood Hits	235	Target Neighborhood Hits	193	Shared Neighborhood Hits	36
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

TIAM1_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.314028 (rank : 63)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	63
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.312283 (rank : 66)
Query Neighborhood Hits	235	Target Neighborhood Hits	205	Shared Neighborhood Hits	62
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV2_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.218643 (rank : 101)
Query Neighborhood Hits	235	Target Neighborhood Hits	453	Shared Neighborhood Hits	55
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.234215 (rank : 93)
Query Neighborhood Hits	235	Target Neighborhood Hits	398	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.235231 (rank : 91)
Query Neighborhood Hits	235	Target Neighborhood Hits	404	Shared Neighborhood Hits	53
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.246976 (rank : 88)
Query Neighborhood Hits	235	Target Neighborhood Hits	430	Shared Neighborhood Hits	54
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

FGD5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	235
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
NC score	0.978701 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	235	Target Neighborhood Hits	170	Shared Neighborhood Hits	122
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_HUMAN
NC score	0.906746 (rank : 3)	θ value	9.24197e-138 (rank : 3)
Query Neighborhood Hits	235	Target Neighborhood Hits	237	Shared Neighborhood Hits	116
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
NC score	0.902402 (rank : 4)	θ value	4.29305e-135 (rank : 4)
Query Neighborhood Hits	235	Target Neighborhood Hits	282	Shared Neighborhood Hits	117
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD4_HUMAN
NC score	0.830400 (rank : 5)	θ value	4.84666e-62 (rank : 5)
Query Neighborhood Hits	235	Target Neighborhood Hits	219	Shared Neighborhood Hits	106
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_HUMAN
NC score	0.829453 (rank : 6)	θ value	2.75849e-49 (rank : 9)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	99
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
NC score	0.828046 (rank : 7)	θ value	5.92465e-60 (rank : 6)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	106
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
NC score	0.827711 (rank : 8)	θ value	3.36421e-55 (rank : 7)
Query Neighborhood Hits	235	Target Neighborhood Hits	367	Shared Neighborhood Hits	112
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_MOUSE
NC score	0.826730 (rank : 9)	θ value	4.122e-45 (rank : 10)
Query Neighborhood Hits	235	Target Neighborhood Hits	163	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_MOUSE
NC score	0.826324 (rank : 10)	θ value	8.28633e-54 (rank : 8)
Query Neighborhood Hits	235	Target Neighborhood Hits	387	Shared Neighborhood Hits	114
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
NC score	0.799008 (rank : 11)	θ value	1.05066e-40 (rank : 11)
Query Neighborhood Hits	235	Target Neighborhood Hits	249	Shared Neighborhood Hits	99
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
NC score	0.785498 (rank : 12)	θ value	3.05695e-40 (rank : 12)
Query Neighborhood Hits	235	Target Neighborhood Hits	257	Shared Neighborhood Hits	106
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PKHF1_HUMAN
NC score	0.718762 (rank : 13)	θ value	5.07402e-19 (rank : 16)
Query Neighborhood Hits	235	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.716356 (rank : 14)	θ value	6.62687e-19 (rank : 17)
Query Neighborhood Hits	235	Target Neighborhood Hits	80	Shared Neighborhood Hits	57
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
NC score	0.706053 (rank : 15)	θ value	1.86753e-13 (rank : 19)
Query Neighborhood Hits	235	Target Neighborhood Hits	75	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.705731 (rank : 16)	θ value	1.86753e-13 (rank : 20)
Query Neighborhood Hits	235	Target Neighborhood Hits	77	Shared Neighborhood Hits	57
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ZFY28_HUMAN
NC score	0.553620 (rank : 17)	θ value	1.17247e-07 (rank : 36)
Query Neighborhood Hits	235	Target Neighborhood Hits	152	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.553273 (rank : 18)	θ value	1.133e-10 (rank : 27)
Query Neighborhood Hits	235	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_MOUSE
NC score	0.547509 (rank : 19)	θ value	2.0648e-12 (rank : 22)
Query Neighborhood Hits	235	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.541598 (rank : 20)	θ value	8.40245e-06 (rank : 57)
Query Neighborhood Hits	235	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_HUMAN
NC score	0.539289 (rank : 21)	θ value	2.43908e-13 (rank : 21)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.537228 (rank : 22)	θ value	6.43352e-06 (rank : 53)
Query Neighborhood Hits	235	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ECT2_MOUSE
NC score	0.535187 (rank : 23)	θ value	3.52202e-12 (rank : 23)
Query Neighborhood Hits	235	Target Neighborhood Hits	98	Shared Neighborhood Hits	52
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.525172 (rank : 24)	θ value	1.74796e-11 (rank : 25)
Query Neighborhood Hits	235	Target Neighborhood Hits	98	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.511707 (rank : 25)	θ value	7.84624e-12 (rank : 24)
Query Neighborhood Hits	235	Target Neighborhood Hits	177	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PKHG1_HUMAN
NC score	0.504169 (rank : 26)	θ value	7.58209e-15 (rank : 18)
Query Neighborhood Hits	235	Target Neighborhood Hits	174	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FARP2_MOUSE
NC score	0.501109 (rank : 27)	θ value	8.91499e-32 (rank : 13)
Query Neighborhood Hits	235	Target Neighborhood Hits	209	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
NC score	0.499008 (rank : 28)	θ value	5.77852e-31 (rank : 14)
Query Neighborhood Hits	235	Target Neighborhood Hits	240	Shared Neighborhood Hits	72
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
NC score	0.475960 (rank : 29)	θ value	1.33217e-27 (rank : 15)
Query Neighborhood Hits	235	Target Neighborhood Hits	241	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHGA_MOUSE
NC score	0.455428 (rank : 30)	θ value	1.25267e-09 (rank : 29)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	50
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.453093 (rank : 31)	θ value	1.133e-10 (rank : 26)
Query Neighborhood Hits	235	Target Neighborhood Hits	187	Shared Neighborhood Hits	49
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG5_HUMAN
NC score	0.441391 (rank : 32)	θ value	1.29631e-06 (rank : 45)
Query Neighborhood Hits	235	Target Neighborhood Hits	172	Shared Neighborhood Hits	51
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGG_HUMAN
NC score	0.423543 (rank : 33)	θ value	1.69304e-06 (rank : 47)
Query Neighborhood Hits	235	Target Neighborhood Hits	129	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ZFYV1_HUMAN
NC score	0.420186 (rank : 34)	θ value	1.69304e-06 (rank : 49)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.415563 (rank : 35)	θ value	3.77169e-06 (rank : 51)
Query Neighborhood Hits	235	Target Neighborhood Hits	153	Shared Neighborhood Hits	55
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

HGS_MOUSE
NC score	0.413158 (rank : 36)	θ value	1.17247e-07 (rank : 34)
Query Neighborhood Hits	235	Target Neighborhood Hits	589	Shared Neighborhood Hits	64
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.411334 (rank : 37)	θ value	5.81887e-07 (rank : 38)
Query Neighborhood Hits	235	Target Neighborhood Hits	517	Shared Neighborhood Hits	59
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ARHGG_MOUSE
NC score	0.403848 (rank : 38)	θ value	3.19293e-05 (rank : 62)
Query Neighborhood Hits	235	Target Neighborhood Hits	152	Shared Neighborhood Hits	49
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2_HUMAN
NC score	0.400920 (rank : 39)	θ value	0.0148317 (rank : 87)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

HAPIP_HUMAN
NC score	0.394774 (rank : 40)	θ value	8.97725e-08 (rank : 33)
Query Neighborhood Hits	235	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

NGEF_HUMAN
NC score	0.393108 (rank : 41)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RBNS5_HUMAN
NC score	0.392588 (rank : 42)	θ value	0.00035302 (rank : 70)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

ARHG4_MOUSE
NC score	0.389027 (rank : 43)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	235	Target Neighborhood Hits	185	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHGF_HUMAN
NC score	0.388758 (rank : 44)	θ value	3.19293e-05 (rank : 61)
Query Neighborhood Hits	235	Target Neighborhood Hits	214	Shared Neighborhood Hits	54
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

RBNS5_MOUSE
NC score	0.387170 (rank : 45)	θ value	0.00035302 (rank : 71)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ARHG4_HUMAN
NC score	0.382127 (rank : 46)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NGEF_MOUSE
NC score	0.381555 (rank : 47)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	235	Target Neighborhood Hits	228	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHG4_HUMAN
NC score	0.379495 (rank : 48)	θ value	0.00869519 (rank : 85)
Query Neighborhood Hits	235	Target Neighborhood Hits	200	Shared Neighborhood Hits	42
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHG9_HUMAN
NC score	0.379192 (rank : 49)	θ value	8.40245e-06 (rank : 54)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.377242 (rank : 50)	θ value	8.40245e-06 (rank : 55)
Query Neighborhood Hits	235	Target Neighborhood Hits	234	Shared Neighborhood Hits	50
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG2_MOUSE
NC score	0.374571 (rank : 51)	θ value	7.1131e-05 (rank : 65)
Query Neighborhood Hits	235	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

MCF2L_MOUSE
NC score	0.368354 (rank : 52)	θ value	0.0736092 (rank : 96)
Query Neighborhood Hits	235	Target Neighborhood Hits	255	Shared Neighborhood Hits	57
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FYV1_HUMAN
NC score	0.345711 (rank : 53)	θ value	0.00102713 (rank : 73)
Query Neighborhood Hits	235	Target Neighborhood Hits	217	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.343016 (rank : 54)	θ value	0.00102713 (rank : 74)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY19_HUMAN
NC score	0.338813 (rank : 55)	θ value	0.163984 (rank : 103)
Query Neighborhood Hits	235	Target Neighborhood Hits	206	Shared Neighborhood Hits	54
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ARHG1_HUMAN
NC score	0.337640 (rank : 56)	θ value	0.00102713 (rank : 72)
Query Neighborhood Hits	235	Target Neighborhood Hits	176	Shared Neighborhood Hits	47
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

BCR_HUMAN
NC score	0.331097 (rank : 57)	θ value	4.92598e-06 (rank : 52)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	50
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHG1_MOUSE
NC score	0.330456 (rank : 58)	θ value	0.00390308 (rank : 81)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	51
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ABR_HUMAN
NC score	0.329672 (rank : 59)	θ value	1.29631e-06 (rank : 43)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	48
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHGB_HUMAN
NC score	0.320765 (rank : 60)	θ value	0.000121331 (rank : 66)
Query Neighborhood Hits	235	Target Neighborhood Hits	375	Shared Neighborhood Hits	52
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GNRP_MOUSE
NC score	0.320724 (rank : 61)	θ value	2.36792 (rank : 146)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	63
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ZFY19_MOUSE
NC score	0.317866 (rank : 62)	θ value	2.36792 (rank : 153)
Query Neighborhood Hits	235	Target Neighborhood Hits	143	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

TIAM1_HUMAN
NC score	0.314028 (rank : 63)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	63
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

WDFY3_MOUSE
NC score	0.313301 (rank : 64)	θ value	1.17247e-07 (rank : 35)
Query Neighborhood Hits	235	Target Neighborhood Hits	332	Shared Neighborhood Hits	64
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.312547 (rank : 65)	θ value	1.99992e-07 (rank : 37)
Query Neighborhood Hits	235	Target Neighborhood Hits	348	Shared Neighborhood Hits	63
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

TIAM1_MOUSE
NC score	0.312283 (rank : 66)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	235	Target Neighborhood Hits	205	Shared Neighborhood Hits	62
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

LBC_HUMAN
NC score	0.310361 (rank : 67)	θ value	0.0563607 (rank : 93)
Query Neighborhood Hits	235	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

WDFY1_HUMAN
NC score	0.310117 (rank : 68)	θ value	5.44631e-05 (rank : 64)
Query Neighborhood Hits	235	Target Neighborhood Hits	305	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

RUFY2_MOUSE
NC score	0.301253 (rank : 69)	θ value	7.59969e-07 (rank : 40)
Query Neighborhood Hits	235	Target Neighborhood Hits	820	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

GNRP_HUMAN
NC score	0.301161 (rank : 70)	θ value	4.03905 (rank : 170)
Query Neighborhood Hits	235	Target Neighborhood Hits	239	Shared Neighborhood Hits	67
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RUFY1_MOUSE
NC score	0.298046 (rank : 71)	θ value	2.88788e-06 (rank : 50)
Query Neighborhood Hits	235	Target Neighborhood Hits	765	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

ARHGC_HUMAN
NC score	0.296991 (rank : 72)	θ value	0.0431538 (rank : 91)
Query Neighborhood Hits	235	Target Neighborhood Hits	351	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RUFY1_HUMAN
NC score	0.291927 (rank : 73)	θ value	8.40245e-06 (rank : 56)
Query Neighborhood Hits	235	Target Neighborhood Hits	848	Shared Neighborhood Hits	73
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

ARHG8_HUMAN
NC score	0.290860 (rank : 74)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGC_MOUSE
NC score	0.290847 (rank : 75)	θ value	0.163984 (rank : 100)
Query Neighborhood Hits	235	Target Neighborhood Hits	344	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG2_HUMAN
NC score	0.289503 (rank : 76)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	235	Target Neighborhood Hits	142	Shared Neighborhood Hits	44
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

MTMR3_HUMAN
NC score	0.287148 (rank : 77)	θ value	0.000270298 (rank : 69)
Query Neighborhood Hits	235	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

WDFY2_MOUSE
NC score	0.283855 (rank : 78)	θ value	0.00228821 (rank : 79)
Query Neighborhood Hits	235	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.281829 (rank : 79)	θ value	0.00228821 (rank : 78)
Query Neighborhood Hits	235	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

PKHA6_HUMAN
NC score	0.269463 (rank : 80)	θ value	7.59969e-07 (rank : 39)
Query Neighborhood Hits	235	Target Neighborhood Hits	556	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARHG7_HUMAN
NC score	0.268978 (rank : 81)	θ value	6.88961 (rank : 188)
Query Neighborhood Hits	235	Target Neighborhood Hits	347	Shared Neighborhood Hits	54
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PKHA6_MOUSE
NC score	0.263237 (rank : 82)	θ value	1.29631e-06 (rank : 46)
Query Neighborhood Hits	235	Target Neighborhood Hits	591	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARHG3_HUMAN
NC score	0.259188 (rank : 83)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	235	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.258984 (rank : 84)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	45
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ITSN2_HUMAN
NC score	0.254807 (rank : 85)	θ value	1.43324e-05 (rank : 60)
Query Neighborhood Hits	235	Target Neighborhood Hits	1173	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV_HUMAN
NC score	0.252023 (rank : 86)	θ value	1.09739e-05 (rank : 59)
Query Neighborhood Hits	235	Target Neighborhood Hits	452	Shared Neighborhood Hits	53
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ITSN2_MOUSE
NC score	0.248443 (rank : 87)	θ value	3.19293e-05 (rank : 63)
Query Neighborhood Hits	235	Target Neighborhood Hits	1371	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_MOUSE
NC score	0.246976 (rank : 88)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	235	Target Neighborhood Hits	430	Shared Neighborhood Hits	54
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

RUFY2_HUMAN
NC score	0.244782 (rank : 89)	θ value	9.92553e-07 (rank : 42)
Query Neighborhood Hits	235	Target Neighborhood Hits	1208	Shared Neighborhood Hits	80
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

ARHG7_MOUSE
NC score	0.243949 (rank : 90)	θ value	6.88961 (rank : 189)
Query Neighborhood Hits	235	Target Neighborhood Hits	396	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV3_MOUSE
NC score	0.235231 (rank : 91)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	235	Target Neighborhood Hits	404	Shared Neighborhood Hits	53
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
NC score	0.234336 (rank : 92)	θ value	0.0113563 (rank : 86)
Query Neighborhood Hits	235	Target Neighborhood Hits	456	Shared Neighborhood Hits	56
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
NC score	0.234215 (rank : 93)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	235	Target Neighborhood Hits	398	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ITSN1_HUMAN
NC score	0.232386 (rank : 94)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	235	Target Neighborhood Hits	1757	Shared Neighborhood Hits	85
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.231306 (rank : 95)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	235	Target Neighborhood Hits	1669	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHG8_MOUSE
NC score	0.230770 (rank : 96)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	235	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ZFY27_MOUSE
NC score	0.229727 (rank : 97)	θ value	0.47712 (rank : 113)
Query Neighborhood Hits	235	Target Neighborhood Hits	53	Shared Neighborhood Hits	45
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

DNMBP_MOUSE
NC score	0.229186 (rank : 98)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	235	Target Neighborhood Hits	435	Shared Neighborhood Hits	53
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ZFY27_HUMAN
NC score	0.223913 (rank : 99)	θ value	0.47712 (rank : 112)
Query Neighborhood Hits	235	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

DNMBP_HUMAN
NC score	0.221263 (rank : 100)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	235	Target Neighborhood Hits	413	Shared Neighborhood Hits	57
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_HUMAN
NC score	0.218643 (rank : 101)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	235	Target Neighborhood Hits	453	Shared Neighborhood Hits	55
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

RGNEF_MOUSE
NC score	0.215008 (rank : 102)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	235	Target Neighborhood Hits	641	Shared Neighborhood Hits	57
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

FYCO1_HUMAN
NC score	0.214193 (rank : 103)	θ value	1.09739e-05 (rank : 58)
Query Neighborhood Hits	235	Target Neighborhood Hits	1149	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ANFY1_MOUSE
NC score	0.207259 (rank : 104)	θ value	9.92553e-07 (rank : 41)
Query Neighborhood Hits	235	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.206909 (rank : 105)	θ value	1.29631e-06 (rank : 44)
Query Neighborhood Hits	235	Target Neighborhood Hits	480	Shared Neighborhood Hits	55
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ARHG6_HUMAN
NC score	0.206414 (rank : 106)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	235	Target Neighborhood Hits	376	Shared Neighborhood Hits	47
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

EEA1_MOUSE
NC score	0.200535 (rank : 107)	θ value	3.64472e-09 (rank : 30)
Query Neighborhood Hits	235	Target Neighborhood Hits	1637	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

PKHA4_MOUSE
NC score	0.199357 (rank : 108)	θ value	0.00390308 (rank : 83)
Query Neighborhood Hits	235	Target Neighborhood Hits	202	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
NC score	0.198753 (rank : 109)	θ value	0.00228821 (rank : 77)
Query Neighborhood Hits	235	Target Neighborhood Hits	455	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_HUMAN
NC score	0.195380 (rank : 110)	θ value	0.00390308 (rank : 82)
Query Neighborhood Hits	235	Target Neighborhood Hits	283	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

FYCO1_MOUSE
NC score	0.195088 (rank : 111)	θ value	0.000121331 (rank : 67)
Query Neighborhood Hits	235	Target Neighborhood Hits	1059	Shared Neighborhood Hits	76
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

SOS2_HUMAN
NC score	0.188780 (rank : 112)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	235	Target Neighborhood Hits	193	Shared Neighborhood Hits	36
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

EEA1_HUMAN
NC score	0.185996 (rank : 113)	θ value	6.21693e-09 (rank : 32)
Query Neighborhood Hits	235	Target Neighborhood Hits	1796	Shared Neighborhood Hits	92
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

SOS1_HUMAN
NC score	0.185871 (rank : 114)	θ value	0.0193708 (rank : 88)
Query Neighborhood Hits	235	Target Neighborhood Hits	274	Shared Neighborhood Hits	36
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ARHG6_MOUSE
NC score	0.185863 (rank : 115)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	235	Target Neighborhood Hits	394	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SOS1_MOUSE
NC score	0.171729 (rank : 116)	θ value	0.0252991 (rank : 89)
Query Neighborhood Hits	235	Target Neighborhood Hits	281	Shared Neighborhood Hits	34
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

DUET_HUMAN
NC score	0.162131 (rank : 117)	θ value	2.52405e-10 (rank : 28)
Query Neighborhood Hits	235	Target Neighborhood Hits	1220	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.159320 (rank : 118)	θ value	3.64472e-09 (rank : 31)
Query Neighborhood Hits	235	Target Neighborhood Hits	1580	Shared Neighborhood Hits	76
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

CNKR2_MOUSE
NC score	0.157230 (rank : 119)	θ value	0.00175202 (rank : 76)
Query Neighborhood Hits	235	Target Neighborhood Hits	197	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.156840 (rank : 120)	θ value	0.00175202 (rank : 75)
Query Neighborhood Hits	235	Target Neighborhood Hits	197	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR1_HUMAN
NC score	0.152454 (rank : 121)	θ value	0.21417 (rank : 104)
Query Neighborhood Hits	235	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

ALS2_MOUSE
NC score	0.107637 (rank : 122)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	235	Target Neighborhood Hits	111	Shared Neighborhood Hits	20
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ALS2_HUMAN
NC score	0.093914 (rank : 123)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	235	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

CYH3_MOUSE
NC score	0.092224 (rank : 124)	θ value	0.813845 (rank : 122)
Query Neighborhood Hits	235	Target Neighborhood Hits	148	Shared Neighborhood Hits	47
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

PKHA2_MOUSE
NC score	0.090624 (rank : 125)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	235	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

OSBL9_HUMAN
NC score	0.087211 (rank : 126)	θ value	0.0961366 (rank : 97)
Query Neighborhood Hits	235	Target Neighborhood Hits	138	Shared Neighborhood Hits	32
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

RASA2_MOUSE
NC score	0.086977 (rank : 127)	θ value	0.000121331 (rank : 68)
Query Neighborhood Hits	235	Target Neighborhood Hits	159	Shared Neighborhood Hits	24
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SWP70_HUMAN
NC score	0.084805 (rank : 128)	θ value	4.03905 (rank : 174)
Query Neighborhood Hits	235	Target Neighborhood Hits	973	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RFFL_MOUSE
NC score	0.083476 (rank : 129)	θ value	6.88961 (rank : 208)
Query Neighborhood Hits	235	Target Neighborhood Hits	145	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

SWP70_MOUSE
NC score	0.083211 (rank : 130)	θ value	3.0926 (rank : 164)
Query Neighborhood Hits	235	Target Neighborhood Hits	1097	Shared Neighborhood Hits	74
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

OBSCN_HUMAN
NC score	0.082596 (rank : 131)	θ value	1.69304e-06 (rank : 48)
Query Neighborhood Hits	235	Target Neighborhood Hits	1931	Shared Neighborhood Hits	53
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

RNF34_MOUSE
NC score	0.081901 (rank : 132)	θ value	3.0926 (rank : 163)
Query Neighborhood Hits	235	Target Neighborhood Hits	160	Shared Neighborhood Hits	40
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

CYH4_MOUSE
NC score	0.078728 (rank : 133)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	235	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH3_HUMAN
NC score	0.078619 (rank : 134)	θ value	0.813845 (rank : 121)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

PKHA2_HUMAN
NC score	0.077626 (rank : 135)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	235	Target Neighborhood Hits	119	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RNF34_HUMAN
NC score	0.076893 (rank : 136)	θ value	4.03905 (rank : 173)
Query Neighborhood Hits	235	Target Neighborhood Hits	153	Shared Neighborhood Hits	35
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

CYH1_HUMAN
NC score	0.076601 (rank : 137)	θ value	1.38821 (rank : 130)
Query Neighborhood Hits	235	Target Neighborhood Hits	184	Shared Neighborhood Hits	55
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

RFFL_HUMAN
NC score	0.075547 (rank : 138)	θ value	3.0926 (rank : 162)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RASA2_HUMAN
NC score	0.074685 (rank : 139)	θ value	0.00298849 (rank : 80)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	22
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CYH1_MOUSE
NC score	0.073725 (rank : 140)	θ value	1.38821 (rank : 131)
Query Neighborhood Hits	235	Target Neighborhood Hits	176	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

RUFY3_MOUSE
NC score	0.072798 (rank : 141)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	235	Target Neighborhood Hits	579	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

CYH4_HUMAN
NC score	0.072461 (rank : 142)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	235	Target Neighborhood Hits	135	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

RUFY3_HUMAN
NC score	0.071640 (rank : 143)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	235	Target Neighborhood Hits	594	Shared Neighborhood Hits	20
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

PLEK_HUMAN
NC score	0.071172 (rank : 144)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	235	Target Neighborhood Hits	110	Shared Neighborhood Hits	37
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

RASA3_HUMAN
NC score	0.068668 (rank : 145)	θ value	0.0961366 (rank : 98)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

3BP2_HUMAN
NC score	0.068252 (rank : 146)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	235	Target Neighborhood Hits	296	Shared Neighborhood Hits	28
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

DGKH_HUMAN
NC score	0.066823 (rank : 147)	θ value	2.36792 (rank : 145)
Query Neighborhood Hits	235	Target Neighborhood Hits	255	Shared Neighborhood Hits	45
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

RASA3_MOUSE
NC score	0.066661 (rank : 148)	θ value	0.365318 (rank : 111)
Query Neighborhood Hits	235	Target Neighborhood Hits	144	Shared Neighborhood Hits	28
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

CYH2_MOUSE
NC score	0.066451 (rank : 149)	θ value	6.88961 (rank : 194)
Query Neighborhood Hits	235	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.066436 (rank : 150)	θ value	6.88961 (rank : 193)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	48
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

3BP2_MOUSE
NC score	0.065708 (rank : 151)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	235	Target Neighborhood Hits	142	Shared Neighborhood Hits	31
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

41_HUMAN
NC score	0.065538 (rank : 152)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	12
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41LB_HUMAN
NC score	0.064829 (rank : 153)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	235	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41L5_HUMAN
NC score	0.064401 (rank : 154)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	235	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41L3_HUMAN
NC score	0.064385 (rank : 155)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	235	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41LB_MOUSE
NC score	0.064183 (rank : 156)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	235	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

41_MOUSE
NC score	0.063901 (rank : 157)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	235	Target Neighborhood Hits	184	Shared Neighborhood Hits	13
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L2_MOUSE
NC score	0.063106 (rank : 158)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	235	Target Neighborhood Hits	459	Shared Neighborhood Hits	20
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_MOUSE
NC score	0.062770 (rank : 159)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	235	Target Neighborhood Hits	250	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

FRMD5_MOUSE
NC score	0.062722 (rank : 160)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	235	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

PLEK_MOUSE
NC score	0.062487 (rank : 161)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	235	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

E41L2_HUMAN
NC score	0.062444 (rank : 162)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	235	Target Neighborhood Hits	287	Shared Neighborhood Hits	13
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

FRMD5_HUMAN
NC score	0.062305 (rank : 163)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	235	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41L1_MOUSE
NC score	0.061573 (rank : 164)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	235	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_HUMAN
NC score	0.061395 (rank : 165)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	235	Target Neighborhood Hits	180	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41LA_HUMAN
NC score	0.058411 (rank : 166)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	235	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
NC score	0.057979 (rank : 167)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	6
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

PKHA1_HUMAN
NC score	0.057529 (rank : 168)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	235	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

C43BP_HUMAN
NC score	0.057377 (rank : 169)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	235	Target Neighborhood Hits	87	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PKHA1_MOUSE
NC score	0.057139 (rank : 170)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	235	Target Neighborhood Hits	120	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

C43BP_MOUSE
NC score	0.056956 (rank : 171)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	235	Target Neighborhood Hits	91	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PKHA3_HUMAN
NC score	0.056258 (rank : 172)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	235	Target Neighborhood Hits	66	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

MYLIP_HUMAN
NC score	0.056126 (rank : 173)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	235	Target Neighborhood Hits	162	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
NC score	0.056116 (rank : 174)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	235	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

CJ064_HUMAN
NC score	0.055717 (rank : 175)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	235	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

PKHA3_MOUSE
NC score	0.055010 (rank : 176)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	235	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

RHG25_HUMAN
NC score	0.053434 (rank : 177)	θ value	6.88961 (rank : 209)
Query Neighborhood Hits	235	Target Neighborhood Hits	550	Shared Neighborhood Hits	56
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MOES_MOUSE
NC score	0.053378 (rank : 178)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	235	Target Neighborhood Hits	923	Shared Neighborhood Hits	31
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_HUMAN
NC score	0.052164 (rank : 179)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	235	Target Neighborhood Hits	892	Shared Neighborhood Hits	31
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MTMRD_HUMAN
NC score	0.051241 (rank : 180)	θ value	6.88961 (rank : 204)
Query Neighborhood Hits	235	Target Neighborhood Hits	135	Shared Neighborhood Hits	30
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

RHG25_MOUSE
NC score	0.051187 (rank : 181)	θ value	6.88961 (rank : 210)
Query Neighborhood Hits	235	Target Neighborhood Hits	492	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RADI_HUMAN
NC score	0.050941 (rank : 182)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	235	Target Neighborhood Hits	741	Shared Neighborhood Hits	23
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

MERL_MOUSE
NC score	0.050613 (rank : 183)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	235	Target Neighborhood Hits	524	Shared Neighborhood Hits	20
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

RADI_MOUSE
NC score	0.050363 (rank : 184)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	235	Target Neighborhood Hits	773	Shared Neighborhood Hits	25
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

MERL_HUMAN
NC score	0.050356 (rank : 185)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	235	Target Neighborhood Hits	532	Shared Neighborhood Hits	20
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

EZRI_HUMAN
NC score	0.050308 (rank : 186)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	235	Target Neighborhood Hits	663	Shared Neighborhood Hits	25
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

ZCH13_HUMAN
NC score	0.050255 (rank : 187)	θ value	1.06291 (rank : 128)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WW36	Gene names	ZCCHC13
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 13.

GOGA3_MOUSE
NC score	0.049144 (rank : 188)	θ value	0.365318 (rank : 110)
Query Neighborhood Hits	235	Target Neighborhood Hits	1437	Shared Neighborhood Hits	45
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GMEB1_HUMAN
NC score	0.047476 (rank : 189)	θ value	0.0736092 (rank : 95)
Query Neighborhood Hits	235	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y692, Q9NWH1, Q9UKD0	Gene names	GMEB1
Domain Architecture
Description	Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (Parvovirus initiation factor p96) (PIF p96) (DNA-binding protein p96PIF).

DGKD_HUMAN
NC score	0.046863 (rank : 190)	θ value	6.88961 (rank : 195)
Query Neighborhood Hits	235	Target Neighborhood Hits	231	Shared Neighborhood Hits	25
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

GMEB1_MOUSE
NC score	0.045978 (rank : 191)	θ value	0.0563607 (rank : 92)
Query Neighborhood Hits	235	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JL60	Gene names	Gmeb1
Domain Architecture
Description	Glucocorticoid modulatory element-binding protein 1 (GMEB-1).

PLEK2_MOUSE
NC score	0.044317 (rank : 192)	θ value	2.36792 (rank : 147)
Query Neighborhood Hits	235	Target Neighborhood Hits	96	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_HUMAN
NC score	0.042253 (rank : 193)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	235	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

NACAM_MOUSE
NC score	0.039922 (rank : 194)	θ value	0.00869519 (rank : 84)
Query Neighborhood Hits	235	Target Neighborhood Hits	1866	Shared Neighborhood Hits	52
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

GOGA3_HUMAN
NC score	0.039281 (rank : 195)	θ value	4.03905 (rank : 171)
Query Neighborhood Hits	235	Target Neighborhood Hits	1317	Shared Neighborhood Hits	38
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

SYNE2_HUMAN
NC score	0.038703 (rank : 196)	θ value	0.0563607 (rank : 94)
Query Neighborhood Hits	235	Target Neighborhood Hits	1323	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TGON2_HUMAN
NC score	0.037960 (rank : 197)	θ value	0.0252991 (rank : 90)
Query Neighborhood Hits	235	Target Neighborhood Hits	1037	Shared Neighborhood Hits	45
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

OGFR_HUMAN
NC score	0.037946 (rank : 198)	θ value	0.62314 (rank : 118)
Query Neighborhood Hits	235	Target Neighborhood Hits	1582	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

CTDP1_HUMAN
NC score	0.037567 (rank : 199)	θ value	0.279714 (rank : 106)
Query Neighborhood Hits	235	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

RASA1_HUMAN
NC score	0.037260 (rank : 200)	θ value	1.38821 (rank : 133)
Query Neighborhood Hits	235	Target Neighborhood Hits	258	Shared Neighborhood Hits	31
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PSD4_HUMAN
NC score	0.037038 (rank : 201)	θ value	3.0926 (rank : 161)
Query Neighborhood Hits	235	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

BSCL2_HUMAN
NC score	0.035825 (rank : 202)	θ value	0.163984 (rank : 101)
Query Neighborhood Hits	235	Target Neighborhood Hits	148	Shared Neighborhood Hits	11
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

NBEA_MOUSE
NC score	0.035504 (rank : 203)	θ value	1.81305 (rank : 139)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

GON4L_MOUSE
NC score	0.035038 (rank : 204)	θ value	0.279714 (rank : 107)
Query Neighborhood Hits	235	Target Neighborhood Hits	455	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

TACC1_MOUSE
NC score	0.034584 (rank : 205)	θ value	1.38821 (rank : 134)
Query Neighborhood Hits	235	Target Neighborhood Hits	667	Shared Neighborhood Hits	34
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

BRD8_MOUSE
NC score	0.033649 (rank : 206)	θ value	0.125558 (rank : 99)
Query Neighborhood Hits	235	Target Neighborhood Hits	422	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

CEND2_HUMAN
NC score	0.031246 (rank : 207)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

OSBP1_HUMAN
NC score	0.031236 (rank : 208)	θ value	1.81305 (rank : 140)
Query Neighborhood Hits	235	Target Neighborhood Hits	180	Shared Neighborhood Hits	34
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PSD3_HUMAN
NC score	0.031171 (rank : 209)	θ value	8.99809 (rank : 230)
Query Neighborhood Hits	235	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

TXLNB_HUMAN
NC score	0.030403 (rank : 210)	θ value	0.163984 (rank : 102)
Query Neighborhood Hits	235	Target Neighborhood Hits	912	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

CAPON_MOUSE
NC score	0.030341 (rank : 211)	θ value	0.62314 (rank : 115)
Query Neighborhood Hits	235	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

ANR26_MOUSE
NC score	0.030277 (rank : 212)	θ value	1.38821 (rank : 129)
Query Neighborhood Hits	235	Target Neighborhood Hits	1554	Shared Neighborhood Hits	39
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ERIC1_HUMAN
NC score	0.029491 (rank : 213)	θ value	3.0926 (rank : 157)
Query Neighborhood Hits	235	Target Neighborhood Hits	364	Shared Neighborhood Hits	20
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

CCD41_MOUSE
NC score	0.028875 (rank : 214)	θ value	5.27518 (rank : 179)
Query Neighborhood Hits	235	Target Neighborhood Hits	1399	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

OXR1_MOUSE
NC score	0.028132 (rank : 215)	θ value	0.62314 (rank : 119)
Query Neighborhood Hits	235	Target Neighborhood Hits	516	Shared Neighborhood Hits	25
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

CMGA_HUMAN
NC score	0.027690 (rank : 216)	θ value	2.36792 (rank : 144)
Query Neighborhood Hits	235	Target Neighborhood Hits	238	Shared Neighborhood Hits	18
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

GON4L_HUMAN
NC score	0.026656 (rank : 217)	θ value	4.03905 (rank : 172)
Query Neighborhood Hits	235	Target Neighborhood Hits	555	Shared Neighborhood Hits	29
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

CIC_HUMAN
NC score	0.026643 (rank : 218)	θ value	1.81305 (rank : 137)
Query Neighborhood Hits	235	Target Neighborhood Hits	992	Shared Neighborhood Hits	33
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

IWS1_MOUSE
NC score	0.026425 (rank : 219)	θ value	0.62314 (rank : 117)
Query Neighborhood Hits	235	Target Neighborhood Hits	1258	Shared Neighborhood Hits	51
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PPCT_MOUSE
NC score	0.026014 (rank : 220)	θ value	0.813845 (rank : 123)
Query Neighborhood Hits	235	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P53808, Q9QZX0, Q9R058	Gene names	Pctp, Stard2
Domain Architecture
Description	Phosphatidylcholine transfer protein (PC-TP) (StAR-related lipid transfer protein 2) (StARD2) (START domain-containing protein 2).

ALO17_HUMAN
NC score	0.025367 (rank : 221)	θ value	0.813845 (rank : 120)
Query Neighborhood Hits	235	Target Neighborhood Hits	317	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCF4, Q69YK7, Q8IWF4, Q8IZX1, Q8IZX2, Q8N406	Gene names	KIAA1618, ALO17
Domain Architecture	No domain graphic available
Description	Protein ALO17 (ALK lymphoma oligomerization partner on chromosome 17).

LEO1_HUMAN
NC score	0.024334 (rank : 222)	θ value	0.21417 (rank : 105)
Query Neighborhood Hits	235	Target Neighborhood Hits	958	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

CKAP2_MOUSE
NC score	0.023552 (rank : 223)	θ value	5.27518 (rank : 180)
Query Neighborhood Hits	235	Target Neighborhood Hits	63	Shared Neighborhood Hits	5
SwissProt Accessions	Q3V1H1, Q66LN2, Q8BSF0	Gene names	Ckap2
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2.

ZN638_HUMAN
NC score	0.023549 (rank : 224)	θ value	1.38821 (rank : 136)
Query Neighborhood Hits	235	Target Neighborhood Hits	343	Shared Neighborhood Hits	17
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

CIC_MOUSE
NC score	0.022636 (rank : 225)	θ value	0.62314 (rank : 116)
Query Neighborhood Hits	235	Target Neighborhood Hits	742	Shared Neighborhood Hits	23
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

TAU_HUMAN
NC score	0.022375 (rank : 226)	θ value	0.279714 (rank : 108)
Query Neighborhood Hits	235	Target Neighborhood Hits	448	Shared Neighborhood Hits	18
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ZDHC1_MOUSE
NC score	0.021999 (rank : 227)	θ value	1.38821 (rank : 135)
Query Neighborhood Hits	235	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R0N9, Q8BJ24	Gene names	Zdhhc1
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1).

NASP_HUMAN
NC score	0.021717 (rank : 228)	θ value	6.88961 (rank : 205)
Query Neighborhood Hits	235	Target Neighborhood Hits	709	Shared Neighborhood Hits	37
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

MYCB2_MOUSE
NC score	0.021372 (rank : 229)	θ value	1.06291 (rank : 127)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

AHTF1_HUMAN
NC score	0.021310 (rank : 230)	θ value	3.0926 (rank : 154)
Query Neighborhood Hits	235	Target Neighborhood Hits	286	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WYP5, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6	Gene names	AHCTF1, ELYS, TMBS62
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

RFC1_MOUSE
NC score	0.020129 (rank : 231)	θ value	2.36792 (rank : 149)
Query Neighborhood Hits	235	Target Neighborhood Hits	290	Shared Neighborhood Hits	20
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

MYH8_MOUSE
NC score	0.020092 (rank : 232)	θ value	3.0926 (rank : 159)
Query Neighborhood Hits	235	Target Neighborhood Hits	1600	Shared Neighborhood Hits	44
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

CAPS2_MOUSE
NC score	0.019887 (rank : 233)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	235	Target Neighborhood Hits	78	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BYR5, O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8K3K6	Gene names	Cadps2, Caps2
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

BTBDC_HUMAN
NC score	0.019823 (rank : 234)	θ value	3.0926 (rank : 156)
Query Neighborhood Hits	235	Target Neighborhood Hits	248	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

AMOL1_HUMAN
NC score	0.019757 (rank : 235)	θ value	6.88961 (rank : 186)
Query Neighborhood Hits	235	Target Neighborhood Hits	435	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

TCAL5_HUMAN
NC score	0.019604 (rank : 236)	θ value	0.279714 (rank : 109)
Query Neighborhood Hits	235	Target Neighborhood Hits	806	Shared Neighborhood Hits	33
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

BRD8_HUMAN
NC score	0.019602 (rank : 237)	θ value	4.03905 (rank : 167)
Query Neighborhood Hits	235	Target Neighborhood Hits	292	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

CN037_MOUSE
NC score	0.019496 (rank : 238)	θ value	5.27518 (rank : 181)
Query Neighborhood Hits	235	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BT18, Q8BFQ7, Q8R1Q5, Q9D6C5	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf37 homolog precursor.

RKHD1_HUMAN
NC score	0.019376 (rank : 239)	θ value	6.88961 (rank : 211)
Query Neighborhood Hits	235	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

HAP1_MOUSE
NC score	0.017970 (rank : 240)	θ value	8.99809 (rank : 222)
Query Neighborhood Hits	235	Target Neighborhood Hits	388	Shared Neighborhood Hits	22
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

LEO1_MOUSE
NC score	0.017519 (rank : 241)	θ value	1.81305 (rank : 138)
Query Neighborhood Hits	235	Target Neighborhood Hits	946	Shared Neighborhood Hits	27
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

ITF2_HUMAN
NC score	0.017343 (rank : 242)	θ value	1.06291 (rank : 125)
Query Neighborhood Hits	235	Target Neighborhood Hits	168	Shared Neighborhood Hits	9
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

GAGE8_HUMAN
NC score	0.017132 (rank : 243)	θ value	6.88961 (rank : 200)
Query Neighborhood Hits	235	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UEU5, Q4V325	Gene names	GAGE8
Domain Architecture
Description	G antigen 8 (GAGE-8).

GAGE3_HUMAN
NC score	0.016777 (rank : 244)	θ value	6.88961 (rank : 196)
Query Neighborhood Hits	235	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13067	Gene names	GAGE3
Domain Architecture
Description	G antigen 3 (GAGE-3).

MILK1_MOUSE
NC score	0.016716 (rank : 245)	θ value	6.88961 (rank : 203)
Query Neighborhood Hits	235	Target Neighborhood Hits	788	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

GAGE5_HUMAN
NC score	0.016570 (rank : 246)	θ value	6.88961 (rank : 198)
Query Neighborhood Hits	235	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q13069, Q6FG72	Gene names	GAGE5
Domain Architecture
Description	G antigen 5 (GAGE-5).

GAGE6_HUMAN
NC score	0.016537 (rank : 247)	θ value	6.88961 (rank : 199)
Query Neighborhood Hits	235	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	Q13070	Gene names	GAGE6
Domain Architecture
Description	G antigen 6 (GAGE-6).

GAGE4_HUMAN
NC score	0.016524 (rank : 248)	θ value	6.88961 (rank : 197)
Query Neighborhood Hits	235	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13068, Q6NT33	Gene names	GAGE4
Domain Architecture
Description	G antigen 4 (GAGE-4).

GAGE2_HUMAN
NC score	0.016220 (rank : 249)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	235	Target Neighborhood Hits	50	Shared Neighborhood Hits	12
SwissProt Accessions	Q13066, Q4V322	Gene names	GAGE2
Domain Architecture	No domain graphic available
Description	G antigen 2 (GAGE-2).

TCF25_HUMAN
NC score	0.016162 (rank : 250)	θ value	2.36792 (rank : 150)
Query Neighborhood Hits	235	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQ70, Q2MK75, Q9UPV3	Gene names	TCF25, KIAA1049, NULP1
Domain Architecture
Description	Transcription factor 25 (Nuclear localized protein 1).

CAPS1_HUMAN
NC score	0.016075 (rank : 251)	θ value	6.88961 (rank : 191)
Query Neighborhood Hits	235	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULU8, Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2	Gene names	CADPS, CAPS, CAPS1, KIAA1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

PPCT_HUMAN
NC score	0.015911 (rank : 252)	θ value	8.99809 (rank : 229)
Query Neighborhood Hits	235	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKL6, Q9UIT3, Q9UKW7	Gene names	PCTP, STARD2
Domain Architecture
Description	Phosphatidylcholine transfer protein (PC-TP) (StAR-related lipid transfer protein 2) (StARD2) (START domain-containing protein 2).

CAPS1_MOUSE
NC score	0.015811 (rank : 253)	θ value	6.88961 (rank : 192)
Query Neighborhood Hits	235	Target Neighborhood Hits	93	Shared Neighborhood Hits	15
SwissProt Accessions	Q80TJ1, Q3TSP2, Q61374, Q6AXB4, Q6PGF0	Gene names	Cadps, Caps, Caps1, Kiaa1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

MAGE1_HUMAN
NC score	0.015798 (rank : 254)	θ value	6.88961 (rank : 202)
Query Neighborhood Hits	235	Target Neighborhood Hits	1389	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MYCN_MOUSE
NC score	0.015714 (rank : 255)	θ value	1.38821 (rank : 132)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	7
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

GAGE7_HUMAN
NC score	0.015673 (rank : 256)	θ value	8.99809 (rank : 220)
Query Neighborhood Hits	235	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	O76087, Q4V324	Gene names	GAGE7B, GAGE7
Domain Architecture
Description	G antigen 7 (GAGE-7) (GAGE-7B) (GAGE-8) (AL4).

TLE4_MOUSE
NC score	0.015597 (rank : 257)	θ value	1.81305 (rank : 142)
Query Neighborhood Hits	235	Target Neighborhood Hits	482	Shared Neighborhood Hits	15
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

ITF2_MOUSE
NC score	0.015310 (rank : 258)	θ value	3.0926 (rank : 158)
Query Neighborhood Hits	235	Target Neighborhood Hits	154	Shared Neighborhood Hits	8
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

TLE4_HUMAN
NC score	0.015169 (rank : 259)	θ value	2.36792 (rank : 152)
Query Neighborhood Hits	235	Target Neighborhood Hits	477	Shared Neighborhood Hits	14
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

ZDHC1_HUMAN
NC score	0.014644 (rank : 260)	θ value	5.27518 (rank : 183)
Query Neighborhood Hits	235	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WTX9, O15461	Gene names	ZDHHC1, C16orf1, ZNF377
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) (DHHC- domain-containing cysteine-rich protein 1).

DOCK9_HUMAN
NC score	0.014626 (rank : 261)	θ value	4.03905 (rank : 169)
Query Neighborhood Hits	235	Target Neighborhood Hits	82	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

TE2IP_HUMAN
NC score	0.014308 (rank : 262)	θ value	4.03905 (rank : 175)
Query Neighborhood Hits	235	Target Neighborhood Hits	75	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NYB0, Q8WYZ3, Q9NWR2	Gene names	TERF2IP, RAP1
Domain Architecture	No domain graphic available
Description	Telomeric repeat-binding factor 2-interacting protein 1 (TRF2- interacting telomeric protein Rap1) (hRap1).

REXO1_MOUSE
NC score	0.013635 (rank : 263)	θ value	6.88961 (rank : 207)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

DOCK9_MOUSE
NC score	0.013329 (rank : 264)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	235	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

PP4R1_MOUSE
NC score	0.013090 (rank : 265)	θ value	2.36792 (rank : 148)
Query Neighborhood Hits	235	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

TCAL8_MOUSE
NC score	0.012899 (rank : 266)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	235	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CZY2, Q9CYP9	Gene names	Tceal8
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 8 (TCEA-like protein 8) (Transcription elongation factor S-II protein-like 8).

SYTL1_MOUSE
NC score	0.012771 (rank : 267)	θ value	5.27518 (rank : 182)
Query Neighborhood Hits	235	Target Neighborhood Hits	314	Shared Neighborhood Hits	14
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

CGRE1_HUMAN
NC score	0.011755 (rank : 268)	θ value	4.03905 (rank : 168)
Query Neighborhood Hits	235	Target Neighborhood Hits	354	Shared Neighborhood Hits	13
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

UBP53_MOUSE
NC score	0.011460 (rank : 269)	θ value	4.03905 (rank : 176)
Query Neighborhood Hits	235	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

NIPBL_HUMAN
NC score	0.010978 (rank : 270)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	235	Target Neighborhood Hits	1311	Shared Neighborhood Hits	41
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

TOIP2_HUMAN
NC score	0.010419 (rank : 271)	θ value	6.88961 (rank : 212)
Query Neighborhood Hits	235	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFQ8	Gene names	TOR1AIP2, LULL1
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1).

AKAP8_HUMAN
NC score	0.010257 (rank : 272)	θ value	5.27518 (rank : 178)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	O43823	Gene names	AKAP8, AKAP95
Domain Architecture
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

GRAM3_HUMAN
NC score	0.009331 (rank : 273)	θ value	6.88961 (rank : 201)
Query Neighborhood Hits	235	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q96HH9, Q9H753	Gene names	GRAMD3, NS3TP2
Domain Architecture	No domain graphic available
Description	GRAM domain-containing protein 3 (HCV NS3-transactivated protein 2).

JADE1_HUMAN
NC score	0.009284 (rank : 274)	θ value	1.06291 (rank : 126)
Query Neighborhood Hits	235	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q6IE81, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692	Gene names	PHF17, JADE1, KIAA1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

GRB14_HUMAN
NC score	0.008932 (rank : 275)	θ value	8.99809 (rank : 221)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	14
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

TEAD2_MOUSE
NC score	0.008924 (rank : 276)	θ value	2.36792 (rank : 151)
Query Neighborhood Hits	235	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P48301, Q62297	Gene names	Tead2, Etdf, Etf, Tef4
Domain Architecture
Description	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) (Embryonic TEA domain-containing factor) (ETF) (ETEF-1).

ATBF1_MOUSE
NC score	0.008770 (rank : 277)	θ value	3.0926 (rank : 155)
Query Neighborhood Hits	235	Target Neighborhood Hits	1841	Shared Neighborhood Hits	51
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ANK1_HUMAN
NC score	0.008428 (rank : 278)	θ value	6.88961 (rank : 187)
Query Neighborhood Hits	235	Target Neighborhood Hits	416	Shared Neighborhood Hits	6
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

MAGC1_HUMAN
NC score	0.008249 (rank : 279)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	235	Target Neighborhood Hits	431	Shared Neighborhood Hits	22
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

SPIN3_HUMAN
NC score	0.007883 (rank : 280)	θ value	8.99809 (rank : 232)
Query Neighborhood Hits	235	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q99865, O75650, Q6IPW2, Q9UJJ0	Gene names	SPIN3, DXF34
Domain Architecture
Description	Spindlin-3 (Spindlin-like protein 3) (SPIN-3) (Protein DXF34).

SPIN2_HUMAN
NC score	0.007875 (rank : 281)	θ value	8.99809 (rank : 231)
Query Neighborhood Hits	235	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BPZ2, Q7Z2M0	Gene names	SPIN2
Domain Architecture
Description	Spindlin-2 (Spindlin-like protein 2) (SPIN-2).

BNC2_HUMAN
NC score	0.007013 (rank : 282)	θ value	6.88961 (rank : 190)
Query Neighborhood Hits	235	Target Neighborhood Hits	439	Shared Neighborhood Hits	14
SwissProt Accessions	Q6ZN30, Q6T3A3, Q8NAR2, Q9H6J0, Q9NXV0	Gene names	BNC2
Domain Architecture	No domain graphic available
Description	Zinc finger protein basonuclin-2.

FA13C_HUMAN
NC score	0.006918 (rank : 283)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	235	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NE31, Q99787	Gene names	FAM13C1
Domain Architecture	No domain graphic available
Description	Protein FAM13C1.

MA2B2_MOUSE
NC score	0.004822 (rank : 284)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	235	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

TCF8_HUMAN
NC score	0.004753 (rank : 285)	θ value	0.813845 (rank : 124)
Query Neighborhood Hits	235	Target Neighborhood Hits	1057	Shared Neighborhood Hits	48
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

K1849_MOUSE
NC score	0.003743 (rank : 286)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	235	Target Neighborhood Hits	335	Shared Neighborhood Hits	7
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

HCN4_HUMAN
NC score	0.003637 (rank : 287)	θ value	8.99809 (rank : 223)
Query Neighborhood Hits	235	Target Neighborhood Hits	303	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

CD6_HUMAN
NC score	0.003315 (rank : 288)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	235	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

SUSD4_HUMAN
NC score	0.003228 (rank : 289)	θ value	8.99809 (rank : 233)
Query Neighborhood Hits	235	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q5VX71, Q6UX62, Q9BSR0, Q9NWG0	Gene names	SUSD4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

PGCA_MOUSE
NC score	0.002372 (rank : 290)	θ value	6.88961 (rank : 206)
Query Neighborhood Hits	235	Target Neighborhood Hits	643	Shared Neighborhood Hits	15
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

ZN486_HUMAN
NC score	0.002251 (rank : 291)	θ value	1.81305 (rank : 143)
Query Neighborhood Hits	235	Target Neighborhood Hits	645	Shared Neighborhood Hits	13
SwissProt Accessions	Q96H40	Gene names	ZNF486, KRBO2
Domain Architecture	No domain graphic available
Description	Zinc finger protein 486.

ZFHX2_HUMAN
NC score	0.002227 (rank : 292)	θ value	6.88961 (rank : 213)
Query Neighborhood Hits	235	Target Neighborhood Hits	1178	Shared Neighborhood Hits	34
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

TCF8_MOUSE
NC score	0.002182 (rank : 293)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	235	Target Neighborhood Hits	1067	Shared Neighborhood Hits	31
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

PCDH7_HUMAN
NC score	-0.000298 (rank : 294)	θ value	3.0926 (rank : 160)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	O60245, O60246, O60247	Gene names	PCDH7, BHPCDH
Domain Architecture
Description	Protocadherin-7 precursor (Brain-heart protocadherin) (BH-Pcdh).

ZN690_HUMAN
NC score	-0.001370 (rank : 295)	θ value	0.47712 (rank : 114)
Query Neighborhood Hits	235	Target Neighborhood Hits	777	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IWY8, Q32M75, Q32M76, Q8NA40	Gene names	ZNF690
Domain Architecture	No domain graphic available
Description	Zinc finger protein 690.

ZN496_HUMAN
NC score	-0.001932 (rank : 296)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	235	Target Neighborhood Hits	743	Shared Neighborhood Hits	15
SwissProt Accessions	Q96IT1	Gene names	ZNF496
Domain Architecture	No domain graphic available
Description	Zinc finger protein 496.

TCF17_MOUSE
NC score	-0.001984 (rank : 297)	θ value	1.81305 (rank : 141)
Query Neighborhood Hits	235	Target Neighborhood Hits	786	Shared Neighborhood Hits	18
SwissProt Accessions	Q61751	Gene names	Znf354a, Kid1, Tcf17, Zfp354a
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally- regulated protein 1).

ZN215_HUMAN
NC score	-0.002996 (rank : 298)	θ value	5.27518 (rank : 184)
Query Neighborhood Hits	235	Target Neighborhood Hits	711	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UL58	Gene names	ZNF215, BAZ2
Domain Architecture
Description	Zinc finger protein 215 (BWSCR2-associated zinc-finger protein 2) (BAZ 2).

ZN273_HUMAN
NC score	-0.003249 (rank : 299)	θ value	4.03905 (rank : 177)
Query Neighborhood Hits	235	Target Neighborhood Hits	739	Shared Neighborhood Hits	15
SwissProt Accessions	Q14593, Q6P3V4	Gene names	ZNF273
Domain Architecture	No domain graphic available
Description	Zinc finger protein 273 (Zinc finger protein HZF9).

ZN319_MOUSE
NC score	-0.003653 (rank : 300)	θ value	5.27518 (rank : 185)
Query Neighborhood Hits	235	Target Neighborhood Hits	762	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ERR8	Gene names	Znf319, Zfp319
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

ZN596_HUMAN
NC score	-0.003945 (rank : 301)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	235	Target Neighborhood Hits	716	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TC21, O95015, Q8N9X0	Gene names	ZNF596
Domain Architecture	No domain graphic available
Description	Zinc finger protein 596.