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Network neighborhood for query Sequence : ARHGA_HUMAN

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ARHGA_HUMAN
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARHGA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	187	Target Neighborhood Hits	187	Shared Neighborhood Hits	187
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	0 (rank : 2)	NC score	0.978803 (rank : 2)
Query Neighborhood Hits	187	Target Neighborhood Hits	125	Shared Neighborhood Hits	81
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_MOUSE
θ value	3.07116e-24 (rank : 3)	NC score	0.729749 (rank : 3)
Query Neighborhood Hits	187	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
θ value	1.5242e-23 (rank : 4)	NC score	0.715793 (rank : 4)
Query Neighborhood Hits	187	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

JIP3_MOUSE
θ value	1.29031e-22 (rank : 5)	NC score	0.345593 (rank : 71)
Query Neighborhood Hits	187	Target Neighborhood Hits	759	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

BCR_HUMAN
θ value	4.9032e-22 (rank : 6)	NC score	0.474541 (rank : 40)
Query Neighborhood Hits	187	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

JIP3_HUMAN
θ value	1.09232e-21 (rank : 7)	NC score	0.339544 (rank : 72)
Query Neighborhood Hits	187	Target Neighborhood Hits	1039	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

ABR_HUMAN
θ value	7.0802e-21 (rank : 8)	NC score	0.460761 (rank : 45)
Query Neighborhood Hits	187	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

JIP4_HUMAN
θ value	9.24701e-21 (rank : 9)	NC score	0.356434 (rank : 68)
Query Neighborhood Hits	187	Target Neighborhood Hits	585	Shared Neighborhood Hits	45
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

JIP4_MOUSE
θ value	2.69047e-20 (rank : 10)	NC score	0.354836 (rank : 70)
Query Neighborhood Hits	187	Target Neighborhood Hits	593	Shared Neighborhood Hits	42
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

ITSN1_HUMAN
θ value	9.56915e-18 (rank : 11)	NC score	0.416380 (rank : 62)
Query Neighborhood Hits	187	Target Neighborhood Hits	1757	Shared Neighborhood Hits	117
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	2.13179e-17 (rank : 12)	NC score	0.414813 (rank : 63)
Query Neighborhood Hits	187	Target Neighborhood Hits	1669	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

FGD6_HUMAN
θ value	3.07829e-16 (rank : 13)	NC score	0.569054 (rank : 22)
Query Neighborhood Hits	187	Target Neighborhood Hits	237	Shared Neighborhood Hits	66
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	3.07829e-16 (rank : 14)	NC score	0.574406 (rank : 20)
Query Neighborhood Hits	187	Target Neighborhood Hits	282	Shared Neighborhood Hits	69
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ITSN2_HUMAN
θ value	1.99529e-15 (rank : 15)	NC score	0.444471 (rank : 52)
Query Neighborhood Hits	187	Target Neighborhood Hits	1173	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	7.58209e-15 (rank : 16)	NC score	0.423464 (rank : 61)
Query Neighborhood Hits	187	Target Neighborhood Hits	1371	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG4_MOUSE
θ value	1.68911e-14 (rank : 17)	NC score	0.635648 (rank : 7)
Query Neighborhood Hits	187	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
θ value	8.38298e-14 (rank : 18)	NC score	0.610424 (rank : 9)
Query Neighborhood Hits	187	Target Neighborhood Hits	242	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PREX1_HUMAN
θ value	8.38298e-14 (rank : 19)	NC score	0.652941 (rank : 5)
Query Neighborhood Hits	187	Target Neighborhood Hits	177	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FGD4_MOUSE
θ value	1.09485e-13 (rank : 20)	NC score	0.604030 (rank : 12)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

GNRP_HUMAN
θ value	7.09661e-13 (rank : 21)	NC score	0.467490 (rank : 43)
Query Neighborhood Hits	187	Target Neighborhood Hits	239	Shared Neighborhood Hits	64
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	1.2105e-12 (rank : 22)	NC score	0.493519 (rank : 34)
Query Neighborhood Hits	187	Target Neighborhood Hits	191	Shared Neighborhood Hits	63
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD3_MOUSE
θ value	4.59992e-12 (rank : 23)	NC score	0.623654 (rank : 8)
Query Neighborhood Hits	187	Target Neighborhood Hits	257	Shared Neighborhood Hits	67
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
θ value	1.33837e-11 (rank : 24)	NC score	0.604044 (rank : 11)
Query Neighborhood Hits	187	Target Neighborhood Hits	151	Shared Neighborhood Hits	68
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
θ value	1.33837e-11 (rank : 25)	NC score	0.599869 (rank : 13)
Query Neighborhood Hits	187	Target Neighborhood Hits	219	Shared Neighborhood Hits	75
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_MOUSE
θ value	2.98157e-11 (rank : 26)	NC score	0.595096 (rank : 16)
Query Neighborhood Hits	187	Target Neighborhood Hits	163	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	2.98157e-11 (rank : 27)	NC score	0.604352 (rank : 10)
Query Neighborhood Hits	187	Target Neighborhood Hits	249	Shared Neighborhood Hits	65
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD5_HUMAN
θ value	1.133e-10 (rank : 28)	NC score	0.453093 (rank : 46)
Query Neighborhood Hits	187	Target Neighborhood Hits	235	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

PKHG1_HUMAN
θ value	1.133e-10 (rank : 29)	NC score	0.637444 (rank : 6)
Query Neighborhood Hits	187	Target Neighborhood Hits	174	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

TRIO_HUMAN
θ value	1.9326e-10 (rank : 30)	NC score	0.192123 (rank : 78)
Query Neighborhood Hits	187	Target Neighborhood Hits	1580	Shared Neighborhood Hits	96
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ARHG8_HUMAN
θ value	2.52405e-10 (rank : 31)	NC score	0.593687 (rank : 17)
Query Neighborhood Hits	187	Target Neighborhood Hits	85	Shared Neighborhood Hits	62
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FGD1_MOUSE
θ value	2.52405e-10 (rank : 32)	NC score	0.567886 (rank : 24)
Query Neighborhood Hits	187	Target Neighborhood Hits	387	Shared Neighborhood Hits	67
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG9_HUMAN
θ value	3.29651e-10 (rank : 33)	NC score	0.598217 (rank : 14)
Query Neighborhood Hits	187	Target Neighborhood Hits	235	Shared Neighborhood Hits	64
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	3.29651e-10 (rank : 34)	NC score	0.597616 (rank : 15)
Query Neighborhood Hits	187	Target Neighborhood Hits	234	Shared Neighborhood Hits	64
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

DNMBP_MOUSE
θ value	9.59137e-10 (rank : 35)	NC score	0.484958 (rank : 37)
Query Neighborhood Hits	187	Target Neighborhood Hits	435	Shared Neighborhood Hits	69
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DUET_HUMAN
θ value	9.59137e-10 (rank : 36)	NC score	0.196122 (rank : 77)
Query Neighborhood Hits	187	Target Neighborhood Hits	1220	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHG1_HUMAN
θ value	2.79066e-09 (rank : 37)	NC score	0.522562 (rank : 31)
Query Neighborhood Hits	187	Target Neighborhood Hits	176	Shared Neighborhood Hits	58
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	2.79066e-09 (rank : 38)	NC score	0.492686 (rank : 35)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

VAV3_MOUSE
θ value	4.76016e-09 (rank : 39)	NC score	0.450885 (rank : 49)
Query Neighborhood Hits	187	Target Neighborhood Hits	404	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

FGD1_HUMAN
θ value	8.11959e-09 (rank : 40)	NC score	0.564241 (rank : 25)
Query Neighborhood Hits	187	Target Neighborhood Hits	367	Shared Neighborhood Hits	66
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG7_MOUSE
θ value	1.06045e-08 (rank : 41)	NC score	0.472135 (rank : 41)
Query Neighborhood Hits	187	Target Neighborhood Hits	396	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

NGEF_HUMAN
θ value	1.38499e-08 (rank : 42)	NC score	0.541131 (rank : 29)
Query Neighborhood Hits	187	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

VAV3_HUMAN
θ value	1.80886e-08 (rank : 43)	NC score	0.448429 (rank : 50)
Query Neighborhood Hits	187	Target Neighborhood Hits	398	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG8_MOUSE
θ value	2.36244e-08 (rank : 44)	NC score	0.557965 (rank : 26)
Query Neighborhood Hits	187	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

TIAM1_HUMAN
θ value	4.0297e-08 (rank : 45)	NC score	0.568664 (rank : 23)
Query Neighborhood Hits	187	Target Neighborhood Hits	225	Shared Neighborhood Hits	68
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV_MOUSE
θ value	5.26297e-08 (rank : 46)	NC score	0.451671 (rank : 48)
Query Neighborhood Hits	187	Target Neighborhood Hits	430	Shared Neighborhood Hits	66
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHGB_HUMAN
θ value	6.87365e-08 (rank : 47)	NC score	0.493901 (rank : 33)
Query Neighborhood Hits	187	Target Neighborhood Hits	375	Shared Neighborhood Hits	75
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DNMBP_HUMAN
θ value	6.87365e-08 (rank : 48)	NC score	0.467192 (rank : 44)
Query Neighborhood Hits	187	Target Neighborhood Hits	413	Shared Neighborhood Hits	73
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MCF2L_MOUSE
θ value	6.87365e-08 (rank : 49)	NC score	0.532218 (rank : 30)
Query Neighborhood Hits	187	Target Neighborhood Hits	255	Shared Neighborhood Hits	78
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

VAV_HUMAN
θ value	6.87365e-08 (rank : 50)	NC score	0.439678 (rank : 55)
Query Neighborhood Hits	187	Target Neighborhood Hits	452	Shared Neighborhood Hits	67
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG7_HUMAN
θ value	8.97725e-08 (rank : 51)	NC score	0.468823 (rank : 42)
Query Neighborhood Hits	187	Target Neighborhood Hits	347	Shared Neighborhood Hits	65
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

NGEF_MOUSE
θ value	8.97725e-08 (rank : 52)	NC score	0.503545 (rank : 32)
Query Neighborhood Hits	187	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

TIAM1_MOUSE
θ value	8.97725e-08 (rank : 53)	NC score	0.569298 (rank : 21)
Query Neighborhood Hits	187	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD5_MOUSE
θ value	1.17247e-07 (rank : 54)	NC score	0.426829 (rank : 59)
Query Neighborhood Hits	187	Target Neighborhood Hits	170	Shared Neighborhood Hits	46
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG6_HUMAN
θ value	1.99992e-07 (rank : 55)	NC score	0.445309 (rank : 51)
Query Neighborhood Hits	187	Target Neighborhood Hits	376	Shared Neighborhood Hits	71
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

VAV2_MOUSE
θ value	4.45536e-07 (rank : 56)	NC score	0.444279 (rank : 53)
Query Neighborhood Hits	187	Target Neighborhood Hits	456	Shared Neighborhood Hits	66
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
θ value	5.81887e-07 (rank : 57)	NC score	0.442850 (rank : 54)
Query Neighborhood Hits	187	Target Neighborhood Hits	453	Shared Neighborhood Hits	66
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG3_HUMAN
θ value	2.21117e-06 (rank : 58)	NC score	0.578170 (rank : 18)
Query Neighborhood Hits	187	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	2.88788e-06 (rank : 59)	NC score	0.576757 (rank : 19)
Query Neighborhood Hits	187	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHGC_MOUSE
θ value	3.77169e-06 (rank : 60)	NC score	0.433258 (rank : 57)
Query Neighborhood Hits	187	Target Neighborhood Hits	344	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG5_HUMAN
θ value	4.92598e-06 (rank : 61)	NC score	0.546456 (rank : 27)
Query Neighborhood Hits	187	Target Neighborhood Hits	172	Shared Neighborhood Hits	65
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG6_MOUSE
θ value	4.92598e-06 (rank : 62)	NC score	0.425618 (rank : 60)
Query Neighborhood Hits	187	Target Neighborhood Hits	394	Shared Neighborhood Hits	72
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

MCF2_HUMAN
θ value	1.09739e-05 (rank : 63)	NC score	0.543870 (rank : 28)
Query Neighborhood Hits	187	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGC_HUMAN
θ value	1.43324e-05 (rank : 64)	NC score	0.433573 (rank : 56)
Query Neighborhood Hits	187	Target Neighborhood Hits	351	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	5.44631e-05 (rank : 65)	NC score	0.490161 (rank : 36)
Query Neighborhood Hits	187	Target Neighborhood Hits	214	Shared Neighborhood Hits	62
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PKHG4_HUMAN
θ value	0.00035302 (rank : 66)	NC score	0.432186 (rank : 58)
Query Neighborhood Hits	187	Target Neighborhood Hits	200	Shared Neighborhood Hits	56
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

FARP2_HUMAN
θ value	0.00175202 (rank : 67)	NC score	0.364562 (rank : 67)
Query Neighborhood Hits	187	Target Neighborhood Hits	240	Shared Neighborhood Hits	65
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	0.00175202 (rank : 68)	NC score	0.386676 (rank : 64)
Query Neighborhood Hits	187	Target Neighborhood Hits	209	Shared Neighborhood Hits	70
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

HAPIP_HUMAN
θ value	0.00175202 (rank : 69)	NC score	0.452520 (rank : 47)
Query Neighborhood Hits	187	Target Neighborhood Hits	350	Shared Neighborhood Hits	89
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

GOGA4_HUMAN
θ value	0.00298849 (rank : 70)	NC score	0.075964 (rank : 179)
Query Neighborhood Hits	187	Target Neighborhood Hits	2034	Shared Neighborhood Hits	83
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

ALS2_MOUSE
θ value	0.00665767 (rank : 71)	NC score	0.112216 (rank : 103)
Query Neighborhood Hits	187	Target Neighborhood Hits	111	Shared Neighborhood Hits	19
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

MAP1A_HUMAN
θ value	0.00665767 (rank : 72)	NC score	0.067108 (rank : 212)
Query Neighborhood Hits	187	Target Neighborhood Hits	1626	Shared Neighborhood Hits	76
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

GOGA4_MOUSE
θ value	0.0330416 (rank : 73)	NC score	0.070232 (rank : 195)
Query Neighborhood Hits	187	Target Neighborhood Hits	1939	Shared Neighborhood Hits	74
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ALS2_HUMAN
θ value	0.0736092 (rank : 74)	NC score	0.095502 (rank : 130)
Query Neighborhood Hits	187	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

FARP1_HUMAN
θ value	0.0736092 (rank : 75)	NC score	0.334545 (rank : 73)
Query Neighborhood Hits	187	Target Neighborhood Hits	241	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

CDCA4_MOUSE
θ value	0.0961366 (rank : 76)	NC score	0.046280 (rank : 343)
Query Neighborhood Hits	187	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWM2, Q3U1C0, Q921E8, Q99MP6	Gene names	Cdca4, Hepp
Domain Architecture
Description	Cell division cycle-associated protein 4 (Hematopoietic progenitor protein).

CK5P2_MOUSE
θ value	0.0961366 (rank : 77)	NC score	0.057505 (rank : 254)
Query Neighborhood Hits	187	Target Neighborhood Hits	1151	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

K1688_HUMAN
θ value	0.163984 (rank : 78)	NC score	0.048456 (rank : 338)
Query Neighborhood Hits	187	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

CHD3_HUMAN
θ value	0.21417 (rank : 79)	NC score	0.017485 (rank : 384)
Query Neighborhood Hits	187	Target Neighborhood Hits	397	Shared Neighborhood Hits	13
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

ANR21_HUMAN
θ value	0.279714 (rank : 80)	NC score	0.031958 (rank : 364)
Query Neighborhood Hits	187	Target Neighborhood Hits	864	Shared Neighborhood Hits	48
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

ANR26_MOUSE
θ value	0.279714 (rank : 81)	NC score	0.049966 (rank : 337)
Query Neighborhood Hits	187	Target Neighborhood Hits	1554	Shared Neighborhood Hits	66
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CTRO_MOUSE
θ value	0.279714 (rank : 82)	NC score	0.034428 (rank : 358)
Query Neighborhood Hits	187	Target Neighborhood Hits	2344	Shared Neighborhood Hits	75
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

POT15_HUMAN
θ value	0.279714 (rank : 83)	NC score	0.031262 (rank : 366)
Query Neighborhood Hits	187	Target Neighborhood Hits	893	Shared Neighborhood Hits	46
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

PIBF1_HUMAN
θ value	0.365318 (rank : 84)	NC score	0.067868 (rank : 206)
Query Neighborhood Hits	187	Target Neighborhood Hits	1041	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

SSH2_HUMAN
θ value	0.365318 (rank : 85)	NC score	0.015398 (rank : 393)
Query Neighborhood Hits	187	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

FA50A_MOUSE
θ value	0.47712 (rank : 86)	NC score	0.053425 (rank : 292)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

SDC3_MOUSE
θ value	0.47712 (rank : 87)	NC score	0.031149 (rank : 367)
Query Neighborhood Hits	187	Target Neighborhood Hits	107	Shared Neighborhood Hits	4
SwissProt Accessions	Q64519, Q3UDD9, Q6ZQA4, Q7TQD4	Gene names	Sdc3, Kiaa0468
Domain Architecture
Description	Syndecan-3 precursor (SYND3).

TAOK1_HUMAN
θ value	0.47712 (rank : 88)	NC score	0.026301 (rank : 372)
Query Neighborhood Hits	187	Target Neighborhood Hits	1734	Shared Neighborhood Hits	61
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

U2AFL_HUMAN
θ value	0.47712 (rank : 89)	NC score	0.055187 (rank : 277)
Query Neighborhood Hits	187	Target Neighborhood Hits	503	Shared Neighborhood Hits	47
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

TAOK1_MOUSE
θ value	0.62314 (rank : 90)	NC score	0.025181 (rank : 373)
Query Neighborhood Hits	187	Target Neighborhood Hits	1720	Shared Neighborhood Hits	60
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

CHD5_HUMAN
θ value	0.813845 (rank : 91)	NC score	0.015840 (rank : 390)
Query Neighborhood Hits	187	Target Neighborhood Hits	349	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

DHX37_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.016834 (rank : 387)
Query Neighborhood Hits	187	Target Neighborhood Hits	133	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY37, Q9BUI7, Q9P211	Gene names	DHX37, DDX37, KIAA1517
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.1.-) (DEAH box protein 37).

STK10_HUMAN
θ value	0.813845 (rank : 93)	NC score	0.024833 (rank : 374)
Query Neighborhood Hits	187	Target Neighborhood Hits	1921	Shared Neighborhood Hits	63
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TPR_HUMAN
θ value	0.813845 (rank : 94)	NC score	0.053824 (rank : 287)
Query Neighborhood Hits	187	Target Neighborhood Hits	1921	Shared Neighborhood Hits	79
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

AZI1_MOUSE
θ value	1.06291 (rank : 95)	NC score	0.061643 (rank : 234)
Query Neighborhood Hits	187	Target Neighborhood Hits	990	Shared Neighborhood Hits	59
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BCDO1_HUMAN
θ value	1.06291 (rank : 96)	NC score	0.030490 (rank : 368)
Query Neighborhood Hits	187	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAY6, Q9NVH5	Gene names	BCMO1, BCDO, BCDO1
Domain Architecture
Description	Beta,beta-carotene 15,15'-monooxygenase (EC 1.14.99.36) (Beta-carotene dioxygenase 1).

BCDO1_MOUSE
θ value	1.06291 (rank : 97)	NC score	0.033992 (rank : 359)
Query Neighborhood Hits	187	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JJS6, Q6K1L5, Q8C6N5, Q9ERN9	Gene names	Bcmo1, Bcdo, Bcdo1
Domain Architecture
Description	Beta,beta-carotene 15,15'-monooxygenase (EC 1.14.99.36) (Beta-carotene dioxygenase 1).

MYH4_HUMAN
θ value	1.06291 (rank : 98)	NC score	0.042172 (rank : 353)
Query Neighborhood Hits	187	Target Neighborhood Hits	1377	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH4_MOUSE
θ value	1.06291 (rank : 99)	NC score	0.045204 (rank : 348)
Query Neighborhood Hits	187	Target Neighborhood Hits	1476	Shared Neighborhood Hits	69
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

CCDC9_HUMAN
θ value	1.38821 (rank : 100)	NC score	0.031798 (rank : 365)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

CN145_MOUSE
θ value	1.38821 (rank : 101)	NC score	0.053353 (rank : 295)
Query Neighborhood Hits	187	Target Neighborhood Hits	916	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

GLU2B_HUMAN
θ value	1.38821 (rank : 102)	NC score	0.027630 (rank : 371)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	26
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

MACF1_HUMAN
θ value	1.38821 (rank : 103)	NC score	0.044513 (rank : 350)
Query Neighborhood Hits	187	Target Neighborhood Hits	1341	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.052018 (rank : 314)
Query Neighborhood Hits	187	Target Neighborhood Hits	1321	Shared Neighborhood Hits	65
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MYH8_HUMAN
θ value	1.38821 (rank : 105)	NC score	0.047161 (rank : 341)
Query Neighborhood Hits	187	Target Neighborhood Hits	1610	Shared Neighborhood Hits	70
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYST4_HUMAN
θ value	1.38821 (rank : 106)	NC score	0.021285 (rank : 376)
Query Neighborhood Hits	187	Target Neighborhood Hits	671	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

NFM_HUMAN
θ value	1.38821 (rank : 107)	NC score	0.035242 (rank : 357)
Query Neighborhood Hits	187	Target Neighborhood Hits	1328	Shared Neighborhood Hits	68
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

SPAG1_MOUSE
θ value	1.38821 (rank : 108)	NC score	0.013810 (rank : 399)
Query Neighborhood Hits	187	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	Q80ZX8, Q8CCK7, Q9QZJ3, Q9QZJ4	Gene names	Spag1, Tpis
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS).

JADE2_MOUSE
θ value	1.81305 (rank : 109)	NC score	0.013479 (rank : 400)
Query Neighborhood Hits	187	Target Neighborhood Hits	560	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

MYH6_MOUSE
θ value	1.81305 (rank : 110)	NC score	0.048081 (rank : 340)
Query Neighborhood Hits	187	Target Neighborhood Hits	1501	Shared Neighborhood Hits	67
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

SV2A_HUMAN
θ value	1.81305 (rank : 111)	NC score	0.015457 (rank : 392)
Query Neighborhood Hits	187	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q7L0J3, O94841, Q5QNX8, Q7Z3L6, Q8NBJ6, Q9BVZ9	Gene names	SV2A, KIAA0736
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2A.

CE290_HUMAN
θ value	2.36792 (rank : 112)	NC score	0.058852 (rank : 245)
Query Neighborhood Hits	187	Target Neighborhood Hits	1553	Shared Neighborhood Hits	69
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

GA2L3_HUMAN
θ value	2.36792 (rank : 113)	NC score	0.017583 (rank : 383)
Query Neighborhood Hits	187	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q86XJ1	Gene names	GAS2L3
Domain Architecture	No domain graphic available
Description	GAS2-like protein 3 (Growth arrest-specific 2-like 3).

OXRP_HUMAN
θ value	2.36792 (rank : 114)	NC score	0.015721 (rank : 391)
Query Neighborhood Hits	187	Target Neighborhood Hits	544	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

RPGR1_HUMAN
θ value	2.36792 (rank : 115)	NC score	0.045814 (rank : 346)
Query Neighborhood Hits	187	Target Neighborhood Hits	578	Shared Neighborhood Hits	43
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

AKAP6_HUMAN
θ value	3.0926 (rank : 116)	NC score	0.033723 (rank : 360)
Query Neighborhood Hits	187	Target Neighborhood Hits	263	Shared Neighborhood Hits	25
SwissProt Accessions	Q13023, O15028	Gene names	AKAP6, AKAP100, KIAA0311
Domain Architecture
Description	A-kinase anchor protein 6 (Protein kinase A-anchoring protein 6) (PRKA6) (A-kinase anchor protein 100 kDa) (AKAP 100) (mAKAP).

B3A2_HUMAN
θ value	3.0926 (rank : 117)	NC score	0.006856 (rank : 420)
Query Neighborhood Hits	187	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	P04920, Q45EY5, Q969L3	Gene names	SLC4A2, AE2, EPB3L1, HKB3, MPB3L
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (BND3L).

FA50A_HUMAN
θ value	3.0926 (rank : 118)	NC score	0.048242 (rank : 339)
Query Neighborhood Hits	187	Target Neighborhood Hits	264	Shared Neighborhood Hits	34
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

IQEC3_MOUSE
θ value	3.0926 (rank : 119)	NC score	0.020309 (rank : 378)
Query Neighborhood Hits	187	Target Neighborhood Hits	274	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

LMNA_HUMAN
θ value	3.0926 (rank : 120)	NC score	0.032558 (rank : 362)
Query Neighborhood Hits	187	Target Neighborhood Hits	653	Shared Neighborhood Hits	43
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

LMNA_MOUSE
θ value	3.0926 (rank : 121)	NC score	0.032881 (rank : 361)
Query Neighborhood Hits	187	Target Neighborhood Hits	661	Shared Neighborhood Hits	46
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

MYH8_MOUSE
θ value	3.0926 (rank : 122)	NC score	0.046066 (rank : 344)
Query Neighborhood Hits	187	Target Neighborhood Hits	1600	Shared Neighborhood Hits	74
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH9_MOUSE
θ value	3.0926 (rank : 123)	NC score	0.044769 (rank : 349)
Query Neighborhood Hits	187	Target Neighborhood Hits	1829	Shared Neighborhood Hits	70
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PAR3L_HUMAN
θ value	3.0926 (rank : 124)	NC score	0.019500 (rank : 380)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

RING1_HUMAN
θ value	3.0926 (rank : 125)	NC score	0.010214 (rank : 408)
Query Neighborhood Hits	187	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

SV2A_MOUSE
θ value	3.0926 (rank : 126)	NC score	0.014074 (rank : 397)
Query Neighborhood Hits	187	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIS5, Q80TT0, Q8R0R5	Gene names	Sv2a, Kiaa0736, Sv2
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2A (Synaptic vesicle protein 2A) (Synaptic vesicle protein 2) (Calcium regulator SV2A).

UCP4_HUMAN
θ value	3.0926 (rank : 127)	NC score	0.007302 (rank : 416)
Query Neighborhood Hits	187	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	O95847	Gene names	SLC25A27, UCP4
Domain Architecture
Description	Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27).

ZO1_MOUSE
θ value	3.0926 (rank : 128)	NC score	0.014328 (rank : 395)
Query Neighborhood Hits	187	Target Neighborhood Hits	453	Shared Neighborhood Hits	12
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

CENPH_MOUSE
θ value	4.03905 (rank : 129)	NC score	0.038691 (rank : 354)
Query Neighborhood Hits	187	Target Neighborhood Hits	195	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QYM8, Q8R3K9, Q9D079, Q9D0N1	Gene names	Cenph, Enp
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H).

GCC2_HUMAN
θ value	4.03905 (rank : 130)	NC score	0.053942 (rank : 285)
Query Neighborhood Hits	187	Target Neighborhood Hits	1558	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

H6ST3_HUMAN
θ value	4.03905 (rank : 131)	NC score	0.014830 (rank : 394)
Query Neighborhood Hits	187	Target Neighborhood Hits	66	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IZP7, Q5W0L0, Q68CW6	Gene names	HS6ST3
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 3 (EC 2.8.2.-) (HS6ST-3).

IF38_HUMAN
θ value	4.03905 (rank : 132)	NC score	0.018241 (rank : 381)
Query Neighborhood Hits	187	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q99613, O00215	Gene names	EIF3S8
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 8 (eIF3 p110) (eIF3c).

IQEC3_HUMAN
θ value	4.03905 (rank : 133)	NC score	0.024138 (rank : 375)
Query Neighborhood Hits	187	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

K1C20_HUMAN
θ value	4.03905 (rank : 134)	NC score	0.014232 (rank : 396)
Query Neighborhood Hits	187	Target Neighborhood Hits	468	Shared Neighborhood Hits	35
SwissProt Accessions	P35900	Gene names	KRT20
Domain Architecture
Description	Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT).

KI13B_HUMAN
θ value	4.03905 (rank : 135)	NC score	0.010983 (rank : 407)
Query Neighborhood Hits	187	Target Neighborhood Hits	492	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

MAGE1_HUMAN
θ value	4.03905 (rank : 136)	NC score	0.009219 (rank : 409)
Query Neighborhood Hits	187	Target Neighborhood Hits	1389	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MYH9_HUMAN
θ value	4.03905 (rank : 137)	NC score	0.045873 (rank : 345)
Query Neighborhood Hits	187	Target Neighborhood Hits	1762	Shared Neighborhood Hits	76
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RASD1_MOUSE
θ value	4.03905 (rank : 138)	NC score	0.002407 (rank : 426)
Query Neighborhood Hits	187	Target Neighborhood Hits	241	Shared Neighborhood Hits	3
SwissProt Accessions	O35626	Gene names	Rasd1, Dexras1
Domain Architecture
Description	Dexamethasone-induced Ras-related protein 1.

RBP24_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.053462 (rank : 291)
Query Neighborhood Hits	187	Target Neighborhood Hits	1559	Shared Neighborhood Hits	67
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

UB2Q1_HUMAN
θ value	4.03905 (rank : 140)	NC score	0.016999 (rank : 385)
Query Neighborhood Hits	187	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z7E8, Q3B841, Q5I0X2, Q6IS04, Q6P7P2, Q96MV4, Q9BVX5, Q9UGL6	Gene names	UBE2Q1, NICE5, UBE2Q
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19) (Ubiquitin-protein ligase Q1) (Ubiquitin carrier protein Q1) (Protein NICE-5).

UB2Q1_MOUSE
θ value	4.03905 (rank : 141)	NC score	0.016332 (rank : 388)
Query Neighborhood Hits	187	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSS2, Q3UIY3, Q6P913, Q80UT5, Q8K2T0, Q9D7E1	Gene names	Ube2q1, Ube2q
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19) (Ubiquitin-protein ligase Q1) (Ubiquitin carrier protein Q1).

UBP42_HUMAN
θ value	4.03905 (rank : 142)	NC score	0.008485 (rank : 413)
Query Neighborhood Hits	187	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

YTDC1_HUMAN
θ value	4.03905 (rank : 143)	NC score	0.029874 (rank : 370)
Query Neighborhood Hits	187	Target Neighborhood Hits	458	Shared Neighborhood Hits	28
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ZN518_HUMAN
θ value	4.03905 (rank : 144)	NC score	-0.002310 (rank : 433)
Query Neighborhood Hits	187	Target Neighborhood Hits	780	Shared Neighborhood Hits	5
SwissProt Accessions	Q6AHZ1, O15044, Q32MP4	Gene names	ZNF518, KIAA0335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 518.

ANXA6_HUMAN
θ value	5.27518 (rank : 145)	NC score	0.007211 (rank : 417)
Query Neighborhood Hits	187	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	P08133, Q6ZT79	Gene names	ANXA6, ANX6
Domain Architecture
Description	Annexin A6 (Annexin VI) (Lipocortin VI) (P68) (P70) (Protein III) (Chromobindin-20) (67 kDa calelectrin) (Calphobindin-II) (CPB-II).

LMX1B_HUMAN
θ value	5.27518 (rank : 146)	NC score	0.000120 (rank : 430)
Query Neighborhood Hits	187	Target Neighborhood Hits	404	Shared Neighborhood Hits	3
SwissProt Accessions	O60663, O75463	Gene names	LMX1B
Domain Architecture
Description	LIM homeobox transcription factor 1 beta (LIM/homeobox protein LMX1B) (LIM-homeobox protein 1.2) (LMX-1.2).

MYH7_HUMAN
θ value	5.27518 (rank : 147)	NC score	0.046485 (rank : 342)
Query Neighborhood Hits	187	Target Neighborhood Hits	1559	Shared Neighborhood Hits	72
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

SAPS1_MOUSE
θ value	5.27518 (rank : 148)	NC score	0.009097 (rank : 410)
Query Neighborhood Hits	187	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

SPTB2_MOUSE
θ value	5.27518 (rank : 149)	NC score	0.044395 (rank : 351)
Query Neighborhood Hits	187	Target Neighborhood Hits	770	Shared Neighborhood Hits	54
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SYNE1_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.054001 (rank : 284)
Query Neighborhood Hits	187	Target Neighborhood Hits	1484	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TRI44_MOUSE
θ value	5.27518 (rank : 151)	NC score	0.015983 (rank : 389)
Query Neighborhood Hits	187	Target Neighborhood Hits	327	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

BIG2_HUMAN
θ value	6.88961 (rank : 152)	NC score	0.008749 (rank : 411)
Query Neighborhood Hits	187	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

CF058_HUMAN
θ value	6.88961 (rank : 153)	NC score	0.012910 (rank : 401)
Query Neighborhood Hits	187	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P5S2, Q5VUP2	Gene names	C6orf58
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf58 precursor.

GNAS1_MOUSE
θ value	6.88961 (rank : 154)	NC score	0.004531 (rank : 425)
Query Neighborhood Hits	187	Target Neighborhood Hits	651	Shared Neighborhood Hits	14
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

IF2P_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.043247 (rank : 352)
Query Neighborhood Hits	187	Target Neighborhood Hits	889	Shared Neighborhood Hits	50
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

IFT81_MOUSE
θ value	6.88961 (rank : 156)	NC score	0.056373 (rank : 260)
Query Neighborhood Hits	187	Target Neighborhood Hits	959	Shared Neighborhood Hits	54
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

N4BP2_HUMAN
θ value	6.88961 (rank : 157)	NC score	0.021030 (rank : 377)
Query Neighborhood Hits	187	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q86UW6, Q9NVK2, Q9P2D4	Gene names	N4BP2, B3BP, KIAA1413
Domain Architecture
Description	NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein).

NFM_MOUSE
θ value	6.88961 (rank : 158)	NC score	0.032109 (rank : 363)
Query Neighborhood Hits	187	Target Neighborhood Hits	1159	Shared Neighborhood Hits	61
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

PO2F1_HUMAN
θ value	6.88961 (rank : 159)	NC score	0.001242 (rank : 428)
Query Neighborhood Hits	187	Target Neighborhood Hits	426	Shared Neighborhood Hits	6
SwissProt Accessions	P14859, Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1	Gene names	POU2F1, OCT1, OTF1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

RASD1_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.001542 (rank : 427)
Query Neighborhood Hits	187	Target Neighborhood Hits	236	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y272, Q9NYB4	Gene names	RASD1, AGS1, DEXRAS1
Domain Architecture
Description	Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1).

SET1A_HUMAN
θ value	6.88961 (rank : 161)	NC score	0.016975 (rank : 386)
Query Neighborhood Hits	187	Target Neighborhood Hits	690	Shared Neighborhood Hits	23
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

STAT4_MOUSE
θ value	6.88961 (rank : 162)	NC score	0.005206 (rank : 424)
Query Neighborhood Hits	187	Target Neighborhood Hits	73	Shared Neighborhood Hits	7
SwissProt Accessions	P42228	Gene names	Stat4
Domain Architecture
Description	Signal transducer and activator of transcription 4.

TCAL3_MOUSE
θ value	6.88961 (rank : 163)	NC score	0.008712 (rank : 412)
Query Neighborhood Hits	187	Target Neighborhood Hits	132	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R0A5, Q9CYK5, Q9D1S4	Gene names	Tceal3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

TRIPB_HUMAN
θ value	6.88961 (rank : 164)	NC score	0.059488 (rank : 241)
Query Neighborhood Hits	187	Target Neighborhood Hits	1587	Shared Neighborhood Hits	77
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

UBXD6_HUMAN
θ value	6.88961 (rank : 165)	NC score	0.012741 (rank : 403)
Query Neighborhood Hits	187	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	O00124, Q7Z6F2	Gene names	UBXD6, D8S2298E, REP8
Domain Architecture
Description	UBX domain-containing protein 6 (Reproduction 8 protein) (Protein Rep- 8).

ZAN_MOUSE
θ value	6.88961 (rank : 166)	NC score	-0.000535 (rank : 431)
Query Neighborhood Hits	187	Target Neighborhood Hits	808	Shared Neighborhood Hits	4
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ARI3A_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.014017 (rank : 398)
Query Neighborhood Hits	187	Target Neighborhood Hits	80	Shared Neighborhood Hits	6
SwissProt Accessions	Q99856, Q8IZA7	Gene names	ARID3A, DRIL1, DRX, E2FBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (E2F-binding protein 1).

CCD96_MOUSE
θ value	8.99809 (rank : 168)	NC score	0.055720 (rank : 269)
Query Neighborhood Hits	187	Target Neighborhood Hits	704	Shared Neighborhood Hits	49
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CHD4_MOUSE
θ value	8.99809 (rank : 169)	NC score	0.012524 (rank : 404)
Query Neighborhood Hits	187	Target Neighborhood Hits	408	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CTNA1_HUMAN
θ value	8.99809 (rank : 170)	NC score	0.012210 (rank : 405)
Query Neighborhood Hits	187	Target Neighborhood Hits	83	Shared Neighborhood Hits	16
SwissProt Accessions	P35221, Q12795	Gene names	CTNNA1
Domain Architecture
Description	Catenin alpha-1 (Cadherin-associated protein) (Alpha E-catenin) (NY- REN-13 antigen).

CTNA1_MOUSE
θ value	8.99809 (rank : 171)	NC score	0.011648 (rank : 406)
Query Neighborhood Hits	187	Target Neighborhood Hits	84	Shared Neighborhood Hits	15
SwissProt Accessions	P26231	Gene names	Ctnna1, Catna1
Domain Architecture
Description	Catenin alpha-1 (102 kDa cadherin-associated protein) (CAP102) (Alpha E-catenin).

FEZ1_MOUSE
θ value	8.99809 (rank : 172)	NC score	0.012780 (rank : 402)
Query Neighborhood Hits	187	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K0X8	Gene names	Fez1
Domain Architecture	No domain graphic available
Description	Fasciculation and elongation protein zeta 1 (Zygin-1) (Zygin I).

G3BP2_MOUSE
θ value	8.99809 (rank : 173)	NC score	0.005744 (rank : 421)
Query Neighborhood Hits	187	Target Neighborhood Hits	258	Shared Neighborhood Hits	8
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

GSHR_MOUSE
θ value	8.99809 (rank : 174)	NC score	0.005675 (rank : 422)
Query Neighborhood Hits	187	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P47791, Q7TNC2, Q8BN97, Q8C9Z6	Gene names	Gsr, Gr1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

K0100_HUMAN
θ value	8.99809 (rank : 175)	NC score	0.020251 (rank : 379)
Query Neighborhood Hits	187	Target Neighborhood Hits	132	Shared Neighborhood Hits	19
SwissProt Accessions	Q14667, Q3SYN5, Q49A07, Q5H9T4, Q6WG74, Q6ZP51, Q96HH8	Gene names	KIAA0100, BCOX1
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor (Breast cancer overexpressed gene 1 protein) (Antigen MLAA-22).

K1688_MOUSE
θ value	8.99809 (rank : 176)	NC score	0.038025 (rank : 355)
Query Neighborhood Hits	187	Target Neighborhood Hits	188	Shared Neighborhood Hits	7
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

MADCA_HUMAN
θ value	8.99809 (rank : 177)	NC score	0.018047 (rank : 382)
Query Neighborhood Hits	187	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MYH6_HUMAN
θ value	8.99809 (rank : 178)	NC score	0.045669 (rank : 347)
Query Neighborhood Hits	187	Target Neighborhood Hits	1426	Shared Neighborhood Hits	68
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

NCKX1_HUMAN
θ value	8.99809 (rank : 179)	NC score	0.007327 (rank : 415)
Query Neighborhood Hits	187	Target Neighborhood Hits	223	Shared Neighborhood Hits	10
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

NUCL_MOUSE
θ value	8.99809 (rank : 180)	NC score	0.005586 (rank : 423)
Query Neighborhood Hits	187	Target Neighborhood Hits	425	Shared Neighborhood Hits	14
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

PLMN_MOUSE
θ value	8.99809 (rank : 181)	NC score	-0.002024 (rank : 432)
Query Neighborhood Hits	187	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

PP2CG_HUMAN
θ value	8.99809 (rank : 182)	NC score	0.006916 (rank : 419)
Query Neighborhood Hits	187	Target Neighborhood Hits	140	Shared Neighborhood Hits	10
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

PWP1_MOUSE
θ value	8.99809 (rank : 183)	NC score	0.000939 (rank : 429)
Query Neighborhood Hits	187	Target Neighborhood Hits	278	Shared Neighborhood Hits	5
SwissProt Accessions	Q99LL5, Q9D6T6	Gene names	Pwp1
Domain Architecture	No domain graphic available
Description	Periodic tryptophan protein 1 homolog.

RING1_MOUSE
θ value	8.99809 (rank : 184)	NC score	0.007336 (rank : 414)
Query Neighborhood Hits	187	Target Neighborhood Hits	220	Shared Neighborhood Hits	3
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

SAFB1_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.030041 (rank : 369)
Query Neighborhood Hits	187	Target Neighborhood Hits	493	Shared Neighborhood Hits	40
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

SAFB2_HUMAN
θ value	8.99809 (rank : 186)	NC score	0.037835 (rank : 356)
Query Neighborhood Hits	187	Target Neighborhood Hits	720	Shared Neighborhood Hits	46
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

SNX15_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.006989 (rank : 418)
Query Neighborhood Hits	187	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WE1	Gene names	Snx15
Domain Architecture	No domain graphic available
Description	Sorting nexin-15.

ABI1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.092371 (rank : 139)
Query Neighborhood Hits	187	Target Neighborhood Hits	257	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.097929 (rank : 128)
Query Neighborhood Hits	187	Target Neighborhood Hits	246	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.101323 (rank : 117)
Query Neighborhood Hits	187	Target Neighborhood Hits	350	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.101201 (rank : 118)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.088543 (rank : 149)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.085799 (rank : 155)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.081347 (rank : 166)
Query Neighborhood Hits	187	Target Neighborhood Hits	537	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.077791 (rank : 172)
Query Neighborhood Hits	187	Target Neighborhood Hits	496	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AKAP9_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.056293 (rank : 262)
Query Neighborhood Hits	187	Target Neighborhood Hits	1710	Shared Neighborhood Hits	73
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ANM2_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.074327 (rank : 185)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.069489 (rank : 198)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG2_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.355361 (rank : 69)
Query Neighborhood Hits	187	Target Neighborhood Hits	142	Shared Neighborhood Hits	58
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.385172 (rank : 65)
Query Neighborhood Hits	187	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGG_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.474836 (rank : 39)
Query Neighborhood Hits	187	Target Neighborhood Hits	129	Shared Neighborhood Hits	65
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.476501 (rank : 38)
Query Neighborhood Hits	187	Target Neighborhood Hits	152	Shared Neighborhood Hits	64
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.058203 (rank : 251)
Query Neighborhood Hits	187	Target Neighborhood Hits	956	Shared Neighborhood Hits	58
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.064923 (rank : 221)
Query Neighborhood Hits	187	Target Neighborhood Hits	1244	Shared Neighborhood Hits	71
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.055447 (rank : 274)
Query Neighborhood Hits	187	Target Neighborhood Hits	1156	Shared Neighborhood Hits	56
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

AZI1_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.056661 (rank : 258)
Query Neighborhood Hits	187	Target Neighborhood Hits	1000	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

BAIP2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.055440 (rank : 275)
Query Neighborhood Hits	187	Target Neighborhood Hits	192	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.056247 (rank : 263)
Query Neighborhood Hits	187	Target Neighborhood Hits	185	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.065265 (rank : 219)
Query Neighborhood Hits	187	Target Neighborhood Hits	554	Shared Neighborhood Hits	29
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.067651 (rank : 209)
Query Neighborhood Hits	187	Target Neighborhood Hits	438	Shared Neighborhood Hits	26
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.088662 (rank : 147)
Query Neighborhood Hits	187	Target Neighborhood Hits	156	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.068691 (rank : 204)
Query Neighborhood Hits	187	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CAF1A_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.051184 (rank : 322)
Query Neighborhood Hits	187	Target Neighborhood Hits	736	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CAR11_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.054552 (rank : 280)
Query Neighborhood Hits	187	Target Neighborhood Hits	690	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CASL_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.066824 (rank : 213)
Query Neighborhood Hits	187	Target Neighborhood Hits	259	Shared Neighborhood Hits	23
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.062166 (rank : 231)
Query Neighborhood Hits	187	Target Neighborhood Hits	225	Shared Neighborhood Hits	23
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CCD13_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.053615 (rank : 288)
Query Neighborhood Hits	187	Target Neighborhood Hits	721	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CCD19_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.052608 (rank : 304)
Query Neighborhood Hits	187	Target Neighborhood Hits	639	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CCD41_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.056018 (rank : 267)
Query Neighborhood Hits	187	Target Neighborhood Hits	1139	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD41_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.054750 (rank : 279)
Query Neighborhood Hits	187	Target Neighborhood Hits	1399	Shared Neighborhood Hits	63
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CCD46_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.059331 (rank : 242)
Query Neighborhood Hits	187	Target Neighborhood Hits	1430	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CCD46_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.059856 (rank : 240)
Query Neighborhood Hits	187	Target Neighborhood Hits	1405	Shared Neighborhood Hits	71
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CCD91_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.054227 (rank : 281)
Query Neighborhood Hits	187	Target Neighborhood Hits	868	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CCD91_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.052697 (rank : 302)
Query Neighborhood Hits	187	Target Neighborhood Hits	699	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CD2AP_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.143607 (rank : 88)
Query Neighborhood Hits	187	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.144153 (rank : 87)
Query Neighborhood Hits	187	Target Neighborhood Hits	336	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CDR2_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.052380 (rank : 310)
Query Neighborhood Hits	187	Target Neighborhood Hits	482	Shared Neighborhood Hits	40
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

CE152_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.056608 (rank : 259)
Query Neighborhood Hits	187	Target Neighborhood Hits	976	Shared Neighborhood Hits	56
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CENPF_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.058528 (rank : 247)
Query Neighborhood Hits	187	Target Neighborhood Hits	1932	Shared Neighborhood Hits	77
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CEP55_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.051046 (rank : 324)
Query Neighborhood Hits	187	Target Neighborhood Hits	693	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CEP63_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.053418 (rank : 293)
Query Neighborhood Hits	187	Target Neighborhood Hits	1005	Shared Neighborhood Hits	60
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CF060_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.050776 (rank : 330)
Query Neighborhood Hits	187	Target Neighborhood Hits	1270	Shared Neighborhood Hits	59
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CI093_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.052432 (rank : 308)
Query Neighborhood Hits	187	Target Neighborhood Hits	1088	Shared Neighborhood Hits	58
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CING_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.050384 (rank : 333)
Query Neighborhood Hits	187	Target Neighborhood Hits	1432	Shared Neighborhood Hits	64
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CK5P2_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.055586 (rank : 271)
Query Neighborhood Hits	187	Target Neighborhood Hits	1433	Shared Neighborhood Hits	70
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CN145_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.056331 (rank : 261)
Query Neighborhood Hits	187	Target Neighborhood Hits	1196	Shared Neighborhood Hits	58
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CNTRB_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.051414 (rank : 319)
Query Neighborhood Hits	187	Target Neighborhood Hits	1029	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP135_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.051400 (rank : 320)
Query Neighborhood Hits	187	Target Neighborhood Hits	1278	Shared Neighborhood Hits	61
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP250_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.055716 (rank : 270)
Query Neighborhood Hits	187	Target Neighborhood Hits	1805	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CP250_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.052766 (rank : 301)
Query Neighborhood Hits	187	Target Neighborhood Hits	1583	Shared Neighborhood Hits	68
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CRKL_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.094059 (rank : 134)
Query Neighborhood Hits	187	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.091740 (rank : 140)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.087528 (rank : 152)
Query Neighborhood Hits	187	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.089879 (rank : 145)
Query Neighborhood Hits	187	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.070434 (rank : 194)
Query Neighborhood Hits	187	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CU013_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.050928 (rank : 327)
Query Neighborhood Hits	187	Target Neighborhood Hits	405	Shared Neighborhood Hits	37
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

DBNL_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.084377 (rank : 158)
Query Neighborhood Hits	187	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.079958 (rank : 167)
Query Neighborhood Hits	187	Target Neighborhood Hits	306	Shared Neighborhood Hits	21
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.050950 (rank : 326)
Query Neighborhood Hits	187	Target Neighborhood Hits	592	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.053831 (rank : 286)
Query Neighborhood Hits	187	Target Neighborhood Hits	599	Shared Neighborhood Hits	35
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.053417 (rank : 294)
Query Neighborhood Hits	187	Target Neighborhood Hits	625	Shared Neighborhood Hits	30
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DESP_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.053467 (rank : 290)
Query Neighborhood Hits	187	Target Neighborhood Hits	1470	Shared Neighborhood Hits	69
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

EEA1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.084750 (rank : 156)
Query Neighborhood Hits	187	Target Neighborhood Hits	1796	Shared Neighborhood Hits	78
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.088462 (rank : 150)
Query Neighborhood Hits	187	Target Neighborhood Hits	1637	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.057062 (rank : 256)
Query Neighborhood Hits	187	Target Neighborhood Hits	348	Shared Neighborhood Hits	21
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.062128 (rank : 232)
Query Neighborhood Hits	187	Target Neighborhood Hits	389	Shared Neighborhood Hits	25
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EP15R_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.069365 (rank : 199)
Query Neighborhood Hits	187	Target Neighborhood Hits	1083	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.069790 (rank : 197)
Query Neighborhood Hits	187	Target Neighborhood Hits	1135	Shared Neighborhood Hits	56
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.064907 (rank : 222)
Query Neighborhood Hits	187	Target Neighborhood Hits	1021	Shared Neighborhood Hits	54
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.064441 (rank : 225)
Query Neighborhood Hits	187	Target Neighborhood Hits	820	Shared Neighborhood Hits	47
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FLIP1_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.057497 (rank : 255)
Query Neighborhood Hits	187	Target Neighborhood Hits	1405	Shared Neighborhood Hits	73
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLIP1_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.050126 (rank : 336)
Query Neighborhood Hits	187	Target Neighborhood Hits	1176	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FNBP2_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.077800 (rank : 171)
Query Neighborhood Hits	187	Target Neighborhood Hits	432	Shared Neighborhood Hits	41
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYCO1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.074116 (rank : 187)
Query Neighborhood Hits	187	Target Neighborhood Hits	1149	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.078665 (rank : 170)
Query Neighborhood Hits	187	Target Neighborhood Hits	1059	Shared Neighborhood Hits	67
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

FYV1_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.066673 (rank : 216)
Query Neighborhood Hits	187	Target Neighborhood Hits	217	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.064445 (rank : 224)
Query Neighborhood Hits	187	Target Neighborhood Hits	191	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GCC2_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.052895 (rank : 300)
Query Neighborhood Hits	187	Target Neighborhood Hits	1619	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GOGA3_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.060567 (rank : 237)
Query Neighborhood Hits	187	Target Neighborhood Hits	1437	Shared Neighborhood Hits	69
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GOGB1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.058467 (rank : 248)
Query Neighborhood Hits	187	Target Neighborhood Hits	2297	Shared Neighborhood Hits	85
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

GRAP1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.052393 (rank : 309)
Query Neighborhood Hits	187	Target Neighborhood Hits	1234	Shared Neighborhood Hits	65
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

GRAP2_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.098230 (rank : 123)
Query Neighborhood Hits	187	Target Neighborhood Hits	304	Shared Neighborhood Hits	21
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.098167 (rank : 124)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.117663 (rank : 98)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.115847 (rank : 101)
Query Neighborhood Hits	187	Target Neighborhood Hits	309	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.106601 (rank : 108)
Query Neighborhood Hits	187	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.106555 (rank : 109)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.061626 (rank : 235)
Query Neighborhood Hits	187	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.097947 (rank : 127)
Query Neighborhood Hits	187	Target Neighborhood Hits	358	Shared Neighborhood Hits	21
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.101073 (rank : 120)
Query Neighborhood Hits	187	Target Neighborhood Hits	329	Shared Neighborhood Hits	24
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.092407 (rank : 138)
Query Neighborhood Hits	187	Target Neighborhood Hits	517	Shared Neighborhood Hits	36
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.092575 (rank : 137)
Query Neighborhood Hits	187	Target Neighborhood Hits	589	Shared Neighborhood Hits	37
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HMMR_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.052296 (rank : 312)
Query Neighborhood Hits	187	Target Neighborhood Hits	1082	Shared Neighborhood Hits	59
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

IASPP_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.055248 (rank : 276)
Query Neighborhood Hits	187	Target Neighborhood Hits	688	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.055982 (rank : 268)
Query Neighborhood Hits	187	Target Neighborhood Hits	1024	Shared Neighborhood Hits	36
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IF3A_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.051475 (rank : 318)
Query Neighborhood Hits	187	Target Neighborhood Hits	875	Shared Neighborhood Hits	57
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IF3A_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.052604 (rank : 305)
Query Neighborhood Hits	187	Target Neighborhood Hits	871	Shared Neighborhood Hits	58
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

IFT74_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.052528 (rank : 307)
Query Neighborhood Hits	187	Target Neighborhood Hits	949	Shared Neighborhood Hits	52
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

INCE_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.051785 (rank : 315)
Query Neighborhood Hits	187	Target Neighborhood Hits	978	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

INVO_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.064338 (rank : 227)
Query Neighborhood Hits	187	Target Neighborhood Hits	636	Shared Neighborhood Hits	49
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

KMHN1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.050683 (rank : 331)
Query Neighborhood Hits	187	Target Neighborhood Hits	949	Shared Neighborhood Hits	60
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

LASP1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.066800 (rank : 214)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.064982 (rank : 220)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LBC_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.376525 (rank : 66)
Query Neighborhood Hits	187	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LMO7_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.070545 (rank : 193)
Query Neighborhood Hits	187	Target Neighborhood Hits	507	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LUZP1_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.054213 (rank : 282)
Query Neighborhood Hits	187	Target Neighborhood Hits	940	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

MD1L1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.050664 (rank : 332)
Query Neighborhood Hits	187	Target Neighborhood Hits	893	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MD1L1_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.053513 (rank : 289)
Query Neighborhood Hits	187	Target Neighborhood Hits	1001	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MTMR3_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.052955 (rank : 298)
Query Neighborhood Hits	187	Target Neighborhood Hits	163	Shared Neighborhood Hits	15
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

MYO1E_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.056725 (rank : 257)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	33
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.057785 (rank : 253)
Query Neighborhood Hits	187	Target Neighborhood Hits	275	Shared Neighborhood Hits	34
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.058330 (rank : 250)
Query Neighborhood Hits	187	Target Neighborhood Hits	262	Shared Neighborhood Hits	32
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.154694 (rank : 84)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.146100 (rank : 86)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.127190 (rank : 92)
Query Neighborhood Hits	187	Target Neighborhood Hits	229	Shared Neighborhood Hits	23
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.119603 (rank : 96)
Query Neighborhood Hits	187	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.118098 (rank : 97)
Query Neighborhood Hits	187	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.122102 (rank : 95)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.116310 (rank : 99)
Query Neighborhood Hits	187	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.081959 (rank : 165)
Query Neighborhood Hits	187	Target Neighborhood Hits	457	Shared Neighborhood Hits	47
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.060300 (rank : 238)
Query Neighborhood Hits	187	Target Neighborhood Hits	420	Shared Neighborhood Hits	33
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NIN_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.051579 (rank : 317)
Query Neighborhood Hits	187	Target Neighborhood Hits	1376	Shared Neighborhood Hits	59
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

NOXO1_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.075577 (rank : 181)
Query Neighborhood Hits	187	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.082748 (rank : 162)
Query Neighborhood Hits	187	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.072568 (rank : 190)
Query Neighborhood Hits	187	Target Neighborhood Hits	288	Shared Neighborhood Hits	33
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.082001 (rank : 164)
Query Neighborhood Hits	187	Target Neighborhood Hits	267	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NUMA1_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.052660 (rank : 303)
Query Neighborhood Hits	187	Target Neighborhood Hits	1523	Shared Neighborhood Hits	70
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

OBSCN_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.075562 (rank : 182)
Query Neighborhood Hits	187	Target Neighborhood Hits	1931	Shared Neighborhood Hits	64
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OPTN_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.050835 (rank : 329)
Query Neighborhood Hits	187	Target Neighborhood Hits	827	Shared Neighborhood Hits	57
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

OPTN_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.050851 (rank : 328)
Query Neighborhood Hits	187	Target Neighborhood Hits	1120	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

OSTF1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.084503 (rank : 157)
Query Neighborhood Hits	187	Target Neighborhood Hits	466	Shared Neighborhood Hits	24
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.083786 (rank : 160)
Query Neighborhood Hits	187	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.065415 (rank : 218)
Query Neighborhood Hits	187	Target Neighborhood Hits	479	Shared Neighborhood Hits	41
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.059258 (rank : 244)
Query Neighborhood Hits	187	Target Neighborhood Hits	435	Shared Neighborhood Hits	34
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.059856 (rank : 239)
Query Neighborhood Hits	187	Target Neighborhood Hits	543	Shared Neighborhood Hits	36
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.056150 (rank : 264)
Query Neighborhood Hits	187	Target Neighborhood Hits	519	Shared Neighborhood Hits	36
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.065744 (rank : 217)
Query Neighborhood Hits	187	Target Neighborhood Hits	320	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.064393 (rank : 226)
Query Neighborhood Hits	187	Target Neighborhood Hits	283	Shared Neighborhood Hits	27
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.073186 (rank : 188)
Query Neighborhood Hits	187	Target Neighborhood Hits	339	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.072101 (rank : 192)
Query Neighborhood Hits	187	Target Neighborhood Hits	382	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.068729 (rank : 203)
Query Neighborhood Hits	187	Target Neighborhood Hits	385	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.068358 (rank : 205)
Query Neighborhood Hits	187	Target Neighborhood Hits	380	Shared Neighborhood Hits	41
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PCNT_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.052035 (rank : 313)
Query Neighborhood Hits	187	Target Neighborhood Hits	1551	Shared Neighborhood Hits	72
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PCNT_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.051016 (rank : 325)
Query Neighborhood Hits	187	Target Neighborhood Hits	1207	Shared Neighborhood Hits	65
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PEX13_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.072307 (rank : 191)
Query Neighborhood Hits	187	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.074779 (rank : 184)
Query Neighborhood Hits	187	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA6_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.064803 (rank : 223)
Query Neighborhood Hits	187	Target Neighborhood Hits	556	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.068864 (rank : 202)
Query Neighborhood Hits	187	Target Neighborhood Hits	591	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.175765 (rank : 82)
Query Neighborhood Hits	187	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.174425 (rank : 83)
Query Neighborhood Hits	187	Target Neighborhood Hits	80	Shared Neighborhood Hits	19
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.178578 (rank : 80)
Query Neighborhood Hits	187	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.177750 (rank : 81)
Query Neighborhood Hits	187	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.086980 (rank : 154)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.088571 (rank : 148)
Query Neighborhood Hits	187	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.074963 (rank : 183)
Query Neighborhood Hits	187	Target Neighborhood Hits	280	Shared Neighborhood Hits	17
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.101082 (rank : 119)
Query Neighborhood Hits	187	Target Neighborhood Hits	389	Shared Neighborhood Hits	48
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.095031 (rank : 131)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	43
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RABE1_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.051714 (rank : 316)
Query Neighborhood Hits	187	Target Neighborhood Hits	1104	Shared Neighborhood Hits	61
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RAD50_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.054004 (rank : 283)
Query Neighborhood Hits	187	Target Neighborhood Hits	1317	Shared Neighborhood Hits	67
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAD50_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.052552 (rank : 306)
Query Neighborhood Hits	187	Target Neighborhood Hits	1366	Shared Neighborhood Hits	66
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RB6I2_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.050211 (rank : 335)
Query Neighborhood Hits	187	Target Neighborhood Hits	1584	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RBNS5_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.093280 (rank : 135)
Query Neighborhood Hits	187	Target Neighborhood Hits	242	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.102496 (rank : 115)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RBP1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.064267 (rank : 228)
Query Neighborhood Hits	187	Target Neighborhood Hits	521	Shared Neighborhood Hits	37
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.059281 (rank : 243)
Query Neighborhood Hits	187	Target Neighborhood Hits	493	Shared Neighborhood Hits	36
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

REPS1_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.056021 (rank : 266)
Query Neighborhood Hits	187	Target Neighborhood Hits	205	Shared Neighborhood Hits	8
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.061262 (rank : 236)
Query Neighborhood Hits	187	Target Neighborhood Hits	204	Shared Neighborhood Hits	9
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.067341 (rank : 211)
Query Neighborhood Hits	187	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.067438 (rank : 210)
Query Neighborhood Hits	187	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REST_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.050260 (rank : 334)
Query Neighborhood Hits	187	Target Neighborhood Hits	1605	Shared Neighborhood Hits	67
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RFIP3_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.052297 (rank : 311)
Query Neighborhood Hits	187	Target Neighborhood Hits	1055	Shared Neighborhood Hits	55
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RGNEF_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.330450 (rank : 74)
Query Neighborhood Hits	187	Target Neighborhood Hits	641	Shared Neighborhood Hits	84
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG04_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.090454 (rank : 144)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG25_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.055533 (rank : 273)
Query Neighborhood Hits	187	Target Neighborhood Hits	550	Shared Neighborhood Hits	49
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.053004 (rank : 297)
Query Neighborhood Hits	187	Target Neighborhood Hits	492	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG26_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.076784 (rank : 176)
Query Neighborhood Hits	187	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RILP_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.072648 (rank : 189)
Query Neighborhood Hits	187	Target Neighborhood Hits	249	Shared Neighborhood Hits	17
SwissProt Accessions	Q96NA2, Q71RE6, Q9BSL3, Q9BYS3	Gene names	RILP
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

RILP_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.068964 (rank : 201)
Query Neighborhood Hits	187	Target Neighborhood Hits	257	Shared Neighborhood Hits	19
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

RIMB1_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.061987 (rank : 233)
Query Neighborhood Hits	187	Target Neighborhood Hits	1479	Shared Neighborhood Hits	76
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.064233 (rank : 229)
Query Neighborhood Hits	187	Target Neighborhood Hits	1376	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.064163 (rank : 230)
Query Neighborhood Hits	187	Target Neighborhood Hits	263	Shared Neighborhood Hits	17
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.067839 (rank : 207)
Query Neighborhood Hits	187	Target Neighborhood Hits	246	Shared Neighborhood Hits	24
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.084096 (rank : 159)
Query Neighborhood Hits	187	Target Neighborhood Hits	848	Shared Neighborhood Hits	63
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.086997 (rank : 153)
Query Neighborhood Hits	187	Target Neighborhood Hits	765	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.087779 (rank : 151)
Query Neighborhood Hits	187	Target Neighborhood Hits	1208	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.090923 (rank : 142)
Query Neighborhood Hits	187	Target Neighborhood Hits	820	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.094786 (rank : 132)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.091313 (rank : 141)
Query Neighborhood Hits	187	Target Neighborhood Hits	291	Shared Neighborhood Hits	29
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.090888 (rank : 143)
Query Neighborhood Hits	187	Target Neighborhood Hits	324	Shared Neighborhood Hits	30
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.089651 (rank : 146)
Query Neighborhood Hits	187	Target Neighborhood Hits	319	Shared Neighborhood Hits	32
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.092878 (rank : 136)
Query Neighborhood Hits	187	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.096043 (rank : 129)
Query Neighborhood Hits	187	Target Neighborhood Hits	236	Shared Neighborhood Hits	24
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.152129 (rank : 85)
Query Neighborhood Hits	187	Target Neighborhood Hits	341	Shared Neighborhood Hits	31
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.139923 (rank : 89)
Query Neighborhood Hits	187	Target Neighborhood Hits	332	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.066708 (rank : 215)
Query Neighborhood Hits	187	Target Neighborhood Hits	1041	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.079782 (rank : 168)
Query Neighborhood Hits	187	Target Neighborhood Hits	446	Shared Neighborhood Hits	30
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SNX18_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.051104 (rank : 323)
Query Neighborhood Hits	187	Target Neighborhood Hits	207	Shared Neighborhood Hits	18
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.052908 (rank : 299)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SOS1_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.208462 (rank : 75)
Query Neighborhood Hits	187	Target Neighborhood Hits	274	Shared Neighborhood Hits	42
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.197867 (rank : 76)
Query Neighborhood Hits	187	Target Neighborhood Hits	281	Shared Neighborhood Hits	42
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.186098 (rank : 79)
Query Neighborhood Hits	187	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SPTA1_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.077229 (rank : 174)
Query Neighborhood Hits	187	Target Neighborhood Hits	748	Shared Neighborhood Hits	66
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.076543 (rank : 178)
Query Neighborhood Hits	187	Target Neighborhood Hits	675	Shared Neighborhood Hits	59
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.083163 (rank : 161)
Query Neighborhood Hits	187	Target Neighborhood Hits	888	Shared Neighborhood Hits	66
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.128520 (rank : 91)
Query Neighborhood Hits	187	Target Neighborhood Hits	396	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.131894 (rank : 90)
Query Neighborhood Hits	187	Target Neighborhood Hits	409	Shared Neighborhood Hits	25
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.100415 (rank : 121)
Query Neighborhood Hits	187	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.098058 (rank : 125)
Query Neighborhood Hits	187	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.079391 (rank : 169)
Query Neighborhood Hits	187	Target Neighborhood Hits	390	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.076742 (rank : 177)
Query Neighborhood Hits	187	Target Neighborhood Hits	331	Shared Neighborhood Hits	37
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 401)	NC score	0.077492 (rank : 173)
Query Neighborhood Hits	187	Target Neighborhood Hits	324	Shared Neighborhood Hits	37
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.103201 (rank : 113)
Query Neighborhood Hits	187	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.103934 (rank : 112)
Query Neighborhood Hits	187	Target Neighborhood Hits	232	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.108057 (rank : 106)
Query Neighborhood Hits	187	Target Neighborhood Hits	276	Shared Neighborhood Hits	23
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.104207 (rank : 111)
Query Neighborhood Hits	187	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.103088 (rank : 114)
Query Neighborhood Hits	187	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.102334 (rank : 116)
Query Neighborhood Hits	187	Target Neighborhood Hits	273	Shared Neighborhood Hits	21
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.097958 (rank : 126)
Query Neighborhood Hits	187	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.098859 (rank : 122)
Query Neighborhood Hits	187	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SWP70_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.074134 (rank : 186)
Query Neighborhood Hits	187	Target Neighborhood Hits	973	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.076831 (rank : 175)
Query Neighborhood Hits	187	Target Neighborhood Hits	1097	Shared Neighborhood Hits	75
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYCP1_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.053040 (rank : 296)
Query Neighborhood Hits	187	Target Neighborhood Hits	1456	Shared Neighborhood Hits	68
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TCGAP_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.082597 (rank : 163)
Query Neighborhood Hits	187	Target Neighborhood Hits	872	Shared Neighborhood Hits	33
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.094530 (rank : 133)
Query Neighborhood Hits	187	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TOPB1_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.055562 (rank : 272)
Query Neighborhood Hits	187	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q92547, Q7LGC1, Q9UEB9	Gene names	TOPBP1, KIAA0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-binding protein 1) (DNA topoisomerase IIbeta-binding protein 1) (TopBP1).

TOPB1_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.056129 (rank : 265)
Query Neighborhood Hits	187	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).

TRHY_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.051195 (rank : 321)
Query Neighborhood Hits	187	Target Neighborhood Hits	1385	Shared Neighborhood Hits	57
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

TUFT1_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.054985 (rank : 278)
Query Neighborhood Hits	187	Target Neighborhood Hits	686	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

VINEX_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.126846 (rank : 93)
Query Neighborhood Hits	187	Target Neighborhood Hits	270	Shared Neighborhood Hits	26
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.125229 (rank : 94)
Query Neighborhood Hits	187	Target Neighborhood Hits	286	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WDFY1_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.058351 (rank : 249)
Query Neighborhood Hits	187	Target Neighborhood Hits	305	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY3_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.058657 (rank : 246)
Query Neighborhood Hits	187	Target Neighborhood Hits	348	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.058177 (rank : 252)
Query Neighborhood Hits	187	Target Neighborhood Hits	332	Shared Neighborhood Hits	19
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ZFY16_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.108949 (rank : 105)
Query Neighborhood Hits	187	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.110644 (rank : 104)
Query Neighborhood Hits	187	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.075883 (rank : 180)
Query Neighborhood Hits	187	Target Neighborhood Hits	206	Shared Neighborhood Hits	20
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.069032 (rank : 200)
Query Neighborhood Hits	187	Target Neighborhood Hits	143	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.105053 (rank : 110)
Query Neighborhood Hits	187	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.107109 (rank : 107)
Query Neighborhood Hits	187	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.115382 (rank : 102)
Query Neighborhood Hits	187	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.069814 (rank : 196)
Query Neighborhood Hits	187	Target Neighborhood Hits	166	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.067821 (rank : 208)
Query Neighborhood Hits	187	Target Neighborhood Hits	153	Shared Neighborhood Hits	16
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.116253 (rank : 100)
Query Neighborhood Hits	187	Target Neighborhood Hits	134	Shared Neighborhood Hits	16
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

ARHGA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	187	Target Neighborhood Hits	187	Shared Neighborhood Hits	187
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.978803 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	187	Target Neighborhood Hits	125	Shared Neighborhood Hits	81
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_MOUSE
NC score	0.729749 (rank : 3)	θ value	3.07116e-24 (rank : 3)
Query Neighborhood Hits	187	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.715793 (rank : 4)	θ value	1.5242e-23 (rank : 4)
Query Neighborhood Hits	187	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.652941 (rank : 5)	θ value	8.38298e-14 (rank : 19)
Query Neighborhood Hits	187	Target Neighborhood Hits	177	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PKHG1_HUMAN
NC score	0.637444 (rank : 6)	θ value	1.133e-10 (rank : 29)
Query Neighborhood Hits	187	Target Neighborhood Hits	174	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG4_MOUSE
NC score	0.635648 (rank : 7)	θ value	1.68911e-14 (rank : 17)
Query Neighborhood Hits	187	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD3_MOUSE
NC score	0.623654 (rank : 8)	θ value	4.59992e-12 (rank : 23)
Query Neighborhood Hits	187	Target Neighborhood Hits	257	Shared Neighborhood Hits	67
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHG4_HUMAN
NC score	0.610424 (rank : 9)	θ value	8.38298e-14 (rank : 18)
Query Neighborhood Hits	187	Target Neighborhood Hits	242	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD3_HUMAN
NC score	0.604352 (rank : 10)	θ value	2.98157e-11 (rank : 27)
Query Neighborhood Hits	187	Target Neighborhood Hits	249	Shared Neighborhood Hits	65
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_HUMAN
NC score	0.604044 (rank : 11)	θ value	1.33837e-11 (rank : 24)
Query Neighborhood Hits	187	Target Neighborhood Hits	151	Shared Neighborhood Hits	68
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
NC score	0.604030 (rank : 12)	θ value	1.09485e-13 (rank : 20)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
NC score	0.599869 (rank : 13)	θ value	1.33837e-11 (rank : 25)
Query Neighborhood Hits	187	Target Neighborhood Hits	219	Shared Neighborhood Hits	75
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHG9_HUMAN
NC score	0.598217 (rank : 14)	θ value	3.29651e-10 (rank : 33)
Query Neighborhood Hits	187	Target Neighborhood Hits	235	Shared Neighborhood Hits	64
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.597616 (rank : 15)	θ value	3.29651e-10 (rank : 34)
Query Neighborhood Hits	187	Target Neighborhood Hits	234	Shared Neighborhood Hits	64
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FGD2_MOUSE
NC score	0.595096 (rank : 16)	θ value	2.98157e-11 (rank : 26)
Query Neighborhood Hits	187	Target Neighborhood Hits	163	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG8_HUMAN
NC score	0.593687 (rank : 17)	θ value	2.52405e-10 (rank : 31)
Query Neighborhood Hits	187	Target Neighborhood Hits	85	Shared Neighborhood Hits	62
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG3_HUMAN
NC score	0.578170 (rank : 18)	θ value	2.21117e-06 (rank : 58)
Query Neighborhood Hits	187	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.576757 (rank : 19)	θ value	2.88788e-06 (rank : 59)
Query Neighborhood Hits	187	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

FGD6_MOUSE
NC score	0.574406 (rank : 20)	θ value	3.07829e-16 (rank : 14)
Query Neighborhood Hits	187	Target Neighborhood Hits	282	Shared Neighborhood Hits	69
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

TIAM1_MOUSE
NC score	0.569298 (rank : 21)	θ value	8.97725e-08 (rank : 53)
Query Neighborhood Hits	187	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD6_HUMAN
NC score	0.569054 (rank : 22)	θ value	3.07829e-16 (rank : 13)
Query Neighborhood Hits	187	Target Neighborhood Hits	237	Shared Neighborhood Hits	66
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

TIAM1_HUMAN
NC score	0.568664 (rank : 23)	θ value	4.0297e-08 (rank : 45)
Query Neighborhood Hits	187	Target Neighborhood Hits	225	Shared Neighborhood Hits	68
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD1_MOUSE
NC score	0.567886 (rank : 24)	θ value	2.52405e-10 (rank : 32)
Query Neighborhood Hits	187	Target Neighborhood Hits	387	Shared Neighborhood Hits	67
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.564241 (rank : 25)	θ value	8.11959e-09 (rank : 40)
Query Neighborhood Hits	187	Target Neighborhood Hits	367	Shared Neighborhood Hits	66
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG8_MOUSE
NC score	0.557965 (rank : 26)	θ value	2.36244e-08 (rank : 44)
Query Neighborhood Hits	187	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG5_HUMAN
NC score	0.546456 (rank : 27)	θ value	4.92598e-06 (rank : 61)
Query Neighborhood Hits	187	Target Neighborhood Hits	172	Shared Neighborhood Hits	65
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

MCF2_HUMAN
NC score	0.543870 (rank : 28)	θ value	1.09739e-05 (rank : 63)
Query Neighborhood Hits	187	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NGEF_HUMAN
NC score	0.541131 (rank : 29)	θ value	1.38499e-08 (rank : 42)
Query Neighborhood Hits	187	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

MCF2L_MOUSE
NC score	0.532218 (rank : 30)	θ value	6.87365e-08 (rank : 49)
Query Neighborhood Hits	187	Target Neighborhood Hits	255	Shared Neighborhood Hits	78
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG1_HUMAN
NC score	0.522562 (rank : 31)	θ value	2.79066e-09 (rank : 37)
Query Neighborhood Hits	187	Target Neighborhood Hits	176	Shared Neighborhood Hits	58
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

NGEF_MOUSE
NC score	0.503545 (rank : 32)	θ value	8.97725e-08 (rank : 52)
Query Neighborhood Hits	187	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGB_HUMAN
NC score	0.493901 (rank : 33)	θ value	6.87365e-08 (rank : 47)
Query Neighborhood Hits	187	Target Neighborhood Hits	375	Shared Neighborhood Hits	75
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GNRP_MOUSE
NC score	0.493519 (rank : 34)	θ value	1.2105e-12 (rank : 22)
Query Neighborhood Hits	187	Target Neighborhood Hits	191	Shared Neighborhood Hits	63
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG1_MOUSE
NC score	0.492686 (rank : 35)	θ value	2.79066e-09 (rank : 38)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGF_HUMAN
NC score	0.490161 (rank : 36)	θ value	5.44631e-05 (rank : 65)
Query Neighborhood Hits	187	Target Neighborhood Hits	214	Shared Neighborhood Hits	62
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

DNMBP_MOUSE
NC score	0.484958 (rank : 37)	θ value	9.59137e-10 (rank : 35)
Query Neighborhood Hits	187	Target Neighborhood Hits	435	Shared Neighborhood Hits	69
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGG_MOUSE
NC score	0.476501 (rank : 38)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	187	Target Neighborhood Hits	152	Shared Neighborhood Hits	64
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_HUMAN
NC score	0.474836 (rank : 39)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	187	Target Neighborhood Hits	129	Shared Neighborhood Hits	65
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BCR_HUMAN
NC score	0.474541 (rank : 40)	θ value	4.9032e-22 (rank : 6)
Query Neighborhood Hits	187	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHG7_MOUSE
NC score	0.472135 (rank : 41)	θ value	1.06045e-08 (rank : 41)
Query Neighborhood Hits	187	Target Neighborhood Hits	396	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
NC score	0.468823 (rank : 42)	θ value	8.97725e-08 (rank : 51)
Query Neighborhood Hits	187	Target Neighborhood Hits	347	Shared Neighborhood Hits	65
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GNRP_HUMAN
NC score	0.467490 (rank : 43)	θ value	7.09661e-13 (rank : 21)
Query Neighborhood Hits	187	Target Neighborhood Hits	239	Shared Neighborhood Hits	64
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

DNMBP_HUMAN
NC score	0.467192 (rank : 44)	θ value	6.87365e-08 (rank : 48)
Query Neighborhood Hits	187	Target Neighborhood Hits	413	Shared Neighborhood Hits	73
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ABR_HUMAN
NC score	0.460761 (rank : 45)	θ value	7.0802e-21 (rank : 8)
Query Neighborhood Hits	187	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

FGD5_HUMAN
NC score	0.453093 (rank : 46)	θ value	1.133e-10 (rank : 28)
Query Neighborhood Hits	187	Target Neighborhood Hits	235	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

HAPIP_HUMAN
NC score	0.452520 (rank : 47)	θ value	0.00175202 (rank : 69)
Query Neighborhood Hits	187	Target Neighborhood Hits	350	Shared Neighborhood Hits	89
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

VAV_MOUSE
NC score	0.451671 (rank : 48)	θ value	5.26297e-08 (rank : 46)
Query Neighborhood Hits	187	Target Neighborhood Hits	430	Shared Neighborhood Hits	66
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV3_MOUSE
NC score	0.450885 (rank : 49)	θ value	4.76016e-09 (rank : 39)
Query Neighborhood Hits	187	Target Neighborhood Hits	404	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.448429 (rank : 50)	θ value	1.80886e-08 (rank : 43)
Query Neighborhood Hits	187	Target Neighborhood Hits	398	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG6_HUMAN
NC score	0.445309 (rank : 51)	θ value	1.99992e-07 (rank : 55)
Query Neighborhood Hits	187	Target Neighborhood Hits	376	Shared Neighborhood Hits	71
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ITSN2_HUMAN
NC score	0.444471 (rank : 52)	θ value	1.99529e-15 (rank : 15)
Query Neighborhood Hits	187	Target Neighborhood Hits	1173	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV2_MOUSE
NC score	0.444279 (rank : 53)	θ value	4.45536e-07 (rank : 56)
Query Neighborhood Hits	187	Target Neighborhood Hits	456	Shared Neighborhood Hits	66
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.442850 (rank : 54)	θ value	5.81887e-07 (rank : 57)
Query Neighborhood Hits	187	Target Neighborhood Hits	453	Shared Neighborhood Hits	66
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
NC score	0.439678 (rank : 55)	θ value	6.87365e-08 (rank : 50)
Query Neighborhood Hits	187	Target Neighborhood Hits	452	Shared Neighborhood Hits	67
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHGC_HUMAN
NC score	0.433573 (rank : 56)	θ value	1.43324e-05 (rank : 64)
Query Neighborhood Hits	187	Target Neighborhood Hits	351	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.433258 (rank : 57)	θ value	3.77169e-06 (rank : 60)
Query Neighborhood Hits	187	Target Neighborhood Hits	344	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PKHG4_HUMAN
NC score	0.432186 (rank : 58)	θ value	0.00035302 (rank : 66)
Query Neighborhood Hits	187	Target Neighborhood Hits	200	Shared Neighborhood Hits	56
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

FGD5_MOUSE
NC score	0.426829 (rank : 59)	θ value	1.17247e-07 (rank : 54)
Query Neighborhood Hits	187	Target Neighborhood Hits	170	Shared Neighborhood Hits	46
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG6_MOUSE
NC score	0.425618 (rank : 60)	θ value	4.92598e-06 (rank : 62)
Query Neighborhood Hits	187	Target Neighborhood Hits	394	Shared Neighborhood Hits	72
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ITSN2_MOUSE
NC score	0.423464 (rank : 61)	θ value	7.58209e-15 (rank : 16)
Query Neighborhood Hits	187	Target Neighborhood Hits	1371	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.416380 (rank : 62)	θ value	9.56915e-18 (rank : 11)
Query Neighborhood Hits	187	Target Neighborhood Hits	1757	Shared Neighborhood Hits	117
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.414813 (rank : 63)	θ value	2.13179e-17 (rank : 12)
Query Neighborhood Hits	187	Target Neighborhood Hits	1669	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

FARP2_MOUSE
NC score	0.386676 (rank : 64)	θ value	0.00175202 (rank : 68)
Query Neighborhood Hits	187	Target Neighborhood Hits	209	Shared Neighborhood Hits	70
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG2_MOUSE
NC score	0.385172 (rank : 65)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	187	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

LBC_HUMAN
NC score	0.376525 (rank : 66)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	187	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

FARP2_HUMAN
NC score	0.364562 (rank : 67)	θ value	0.00175202 (rank : 67)
Query Neighborhood Hits	187	Target Neighborhood Hits	240	Shared Neighborhood Hits	65
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

JIP4_HUMAN
NC score	0.356434 (rank : 68)	θ value	9.24701e-21 (rank : 9)
Query Neighborhood Hits	187	Target Neighborhood Hits	585	Shared Neighborhood Hits	45
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

ARHG2_HUMAN
NC score	0.355361 (rank : 69)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	187	Target Neighborhood Hits	142	Shared Neighborhood Hits	58
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

JIP4_MOUSE
NC score	0.354836 (rank : 70)	θ value	2.69047e-20 (rank : 10)
Query Neighborhood Hits	187	Target Neighborhood Hits	593	Shared Neighborhood Hits	42
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

JIP3_MOUSE
NC score	0.345593 (rank : 71)	θ value	1.29031e-22 (rank : 5)
Query Neighborhood Hits	187	Target Neighborhood Hits	759	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

JIP3_HUMAN
NC score	0.339544 (rank : 72)	θ value	1.09232e-21 (rank : 7)
Query Neighborhood Hits	187	Target Neighborhood Hits	1039	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

FARP1_HUMAN
NC score	0.334545 (rank : 73)	θ value	0.0736092 (rank : 75)
Query Neighborhood Hits	187	Target Neighborhood Hits	241	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

RGNEF_MOUSE
NC score	0.330450 (rank : 74)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	187	Target Neighborhood Hits	641	Shared Neighborhood Hits	84
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SOS1_HUMAN
NC score	0.208462 (rank : 75)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	187	Target Neighborhood Hits	274	Shared Neighborhood Hits	42
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.197867 (rank : 76)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	187	Target Neighborhood Hits	281	Shared Neighborhood Hits	42
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

DUET_HUMAN
NC score	0.196122 (rank : 77)	θ value	9.59137e-10 (rank : 36)
Query Neighborhood Hits	187	Target Neighborhood Hits	1220	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.192123 (rank : 78)	θ value	1.9326e-10 (rank : 30)
Query Neighborhood Hits	187	Target Neighborhood Hits	1580	Shared Neighborhood Hits	96
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SOS2_HUMAN
NC score	0.186098 (rank : 79)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	187	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

PKHF2_HUMAN
NC score	0.178578 (rank : 80)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	187	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.177750 (rank : 81)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	187	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_HUMAN
NC score	0.175765 (rank : 82)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	187	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.174425 (rank : 83)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	187	Target Neighborhood Hits	80	Shared Neighborhood Hits	19
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

NCF1_HUMAN
NC score	0.154694 (rank : 84)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SH3K1_HUMAN
NC score	0.152129 (rank : 85)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	187	Target Neighborhood Hits	341	Shared Neighborhood Hits	31
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCF1_MOUSE
NC score	0.146100 (rank : 86)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CD2AP_MOUSE
NC score	0.144153 (rank : 87)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	187	Target Neighborhood Hits	336	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.143607 (rank : 88)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	187	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_MOUSE
NC score	0.139923 (rank : 89)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	187	Target Neighborhood Hits	332	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_MOUSE
NC score	0.131894 (rank : 90)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	187	Target Neighborhood Hits	409	Shared Neighborhood Hits	25
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.128520 (rank : 91)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	187	Target Neighborhood Hits	396	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF2_HUMAN
NC score	0.127190 (rank : 92)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	187	Target Neighborhood Hits	229	Shared Neighborhood Hits	23
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VINEX_HUMAN
NC score	0.126846 (rank : 93)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	187	Target Neighborhood Hits	270	Shared Neighborhood Hits	26
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.125229 (rank : 94)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	187	Target Neighborhood Hits	286	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCK1_HUMAN
NC score	0.122102 (rank : 95)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCF4_HUMAN
NC score	0.119603 (rank : 96)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	187	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
NC score	0.118098 (rank : 97)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	187	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRAP_HUMAN
NC score	0.117663 (rank : 98)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.116310 (rank : 99)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	187	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ZFYV9_HUMAN
NC score	0.116253 (rank : 100)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	187	Target Neighborhood Hits	134	Shared Neighborhood Hits	16
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

GRAP_MOUSE
NC score	0.115847 (rank : 101)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	187	Target Neighborhood Hits	309	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ZFY28_HUMAN
NC score	0.115382 (rank : 102)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	187	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ALS2_MOUSE
NC score	0.112216 (rank : 103)	θ value	0.00665767 (rank : 71)
Query Neighborhood Hits	187	Target Neighborhood Hits	111	Shared Neighborhood Hits	19
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ZFY16_MOUSE
NC score	0.110644 (rank : 104)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	187	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY16_HUMAN
NC score	0.108949 (rank : 105)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	187	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

STAC_HUMAN
NC score	0.108057 (rank : 106)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	187	Target Neighborhood Hits	276	Shared Neighborhood Hits	23
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ZFY21_MOUSE
NC score	0.107109 (rank : 107)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	187	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

GRB2_HUMAN
NC score	0.106601 (rank : 108)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	187	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.106555 (rank : 109)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	187	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ZFY21_HUMAN
NC score	0.105053 (rank : 110)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	187	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

STAC_MOUSE
NC score	0.104207 (rank : 111)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	187	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC3_MOUSE
NC score	0.103934 (rank : 112)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	187	Target Neighborhood Hits	232	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.103201 (rank : 113)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	187	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
NC score	0.103088 (rank : 114)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	187	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

RBNS5_MOUSE
NC score	0.102496 (rank : 115)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

STAM1_MOUSE
NC score	0.102334 (rank : 116)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	187	Target Neighborhood Hits	273	Shared Neighborhood Hits	21
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI2_HUMAN
NC score	0.101323 (rank : 117)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	187	Target Neighborhood Hits	350	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.101201 (rank : 118)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	187	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PPIP1_HUMAN
NC score	0.101082 (rank : 119)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	187	Target Neighborhood Hits	389	Shared Neighborhood Hits	48
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

HCLS1_MOUSE
NC score	0.101073 (rank : 120)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	187	Target Neighborhood Hits	329	Shared Neighborhood Hits	24
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_HUMAN
NC score	0.100415 (rank : 121)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	187	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAM2_MOUSE
NC score	0.098859 (rank : 122)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	187	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

GRAP2_HUMAN
NC score	0.098230 (rank : 123)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	187	Target Neighborhood Hits	304	Shared Neighborhood Hits	21
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.098167 (rank : 124)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SRC8_MOUSE
NC score	0.098058 (rank : 125)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	187	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAM2_HUMAN
NC score	0.097958 (rank : 126)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	187	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

HCLS1_HUMAN
NC score	0.097947 (rank : 127)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	187	Target Neighborhood Hits	358	Shared Neighborhood Hits	21
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI1_MOUSE
NC score	0.097929 (rank : 128)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	187	Target Neighborhood Hits	246	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G3_MOUSE
NC score	0.096043 (rank : 129)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	187	Target Neighborhood Hits	236	Shared Neighborhood Hits	24
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ALS2_HUMAN
NC score	0.095502 (rank : 130)	θ value	0.0736092 (rank : 74)
Query Neighborhood Hits	187	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

PPIP1_MOUSE
NC score	0.095031 (rank : 131)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	43
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SH3G1_HUMAN
NC score	0.094786 (rank : 132)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

TCGAP_MOUSE
NC score	0.094530 (rank : 133)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	187	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CRKL_HUMAN
NC score	0.094059 (rank : 134)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	187	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

RBNS5_HUMAN
NC score	0.093280 (rank : 135)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	187	Target Neighborhood Hits	242	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

SH3G3_HUMAN
NC score	0.092878 (rank : 136)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	187	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

HGS_MOUSE
NC score	0.092575 (rank : 137)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	187	Target Neighborhood Hits	589	Shared Neighborhood Hits	37
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.092407 (rank : 138)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	187	Target Neighborhood Hits	517	Shared Neighborhood Hits	36
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ABI1_HUMAN
NC score	0.092371 (rank : 139)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	187	Target Neighborhood Hits	257	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CRKL_MOUSE
NC score	0.091740 (rank : 140)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH3G1_MOUSE
NC score	0.091313 (rank : 141)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	187	Target Neighborhood Hits	291	Shared Neighborhood Hits	29
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

RUFY2_MOUSE
NC score	0.090923 (rank : 142)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	187	Target Neighborhood Hits	820	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G2_HUMAN
NC score	0.090888 (rank : 143)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	187	Target Neighborhood Hits	324	Shared Neighborhood Hits	30
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

RHG04_HUMAN
NC score	0.090454 (rank : 144)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	187	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CRK_MOUSE
NC score	0.089879 (rank : 145)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	187	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G2_MOUSE
NC score	0.089651 (rank : 146)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	187	Target Neighborhood Hits	319	Shared Neighborhood Hits	32
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

BI2L1_HUMAN
NC score	0.088662 (rank : 147)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	187	Target Neighborhood Hits	156	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PLCG1_MOUSE
NC score	0.088571 (rank : 148)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	187	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ABI3_HUMAN
NC score	0.088543 (rank : 149)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

EEA1_MOUSE
NC score	0.088462 (rank : 150)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	187	Target Neighborhood Hits	1637	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RUFY2_HUMAN
NC score	0.087779 (rank : 151)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	187	Target Neighborhood Hits	1208	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

CRK_HUMAN
NC score	0.087528 (rank : 152)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	187	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

RUFY1_MOUSE
NC score	0.086997 (rank : 153)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	187	Target Neighborhood Hits	765	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

PLCG1_HUMAN
NC score	0.086980 (rank : 154)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ABI3_MOUSE
NC score	0.085799 (rank : 155)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	187	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

EEA1_HUMAN
NC score	0.084750 (rank : 156)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	187	Target Neighborhood Hits	1796	Shared Neighborhood Hits	78
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

OSTF1_HUMAN
NC score	0.084503 (rank : 157)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	187	Target Neighborhood Hits	466	Shared Neighborhood Hits	24
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

DBNL_HUMAN
NC score	0.084377 (rank : 158)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	187	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

RUFY1_HUMAN
NC score	0.084096 (rank : 159)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	187	Target Neighborhood Hits	848	Shared Neighborhood Hits	63
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

OSTF1_MOUSE
NC score	0.083786 (rank : 160)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	187	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SPTA2_HUMAN
NC score	0.083163 (rank : 161)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	187	Target Neighborhood Hits	888	Shared Neighborhood Hits	66
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

NOXO1_MOUSE
NC score	0.082748 (rank : 162)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	187	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

TCGAP_HUMAN
NC score	0.082597 (rank : 163)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	187	Target Neighborhood Hits	872	Shared Neighborhood Hits	33
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

NPHP1_MOUSE
NC score	0.082001 (rank : 164)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	187	Target Neighborhood Hits	267	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NEBL_HUMAN
NC score	0.081959 (rank : 165)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	187	Target Neighborhood Hits	457	Shared Neighborhood Hits	47
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

AHI1_HUMAN
NC score	0.081347 (rank : 166)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	187	Target Neighborhood Hits	537	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

DBNL_MOUSE
NC score	0.079958 (rank : 167)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	187	Target Neighborhood Hits	306	Shared Neighborhood Hits	21
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SHAN2_MOUSE
NC score	0.079782 (rank : 168)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	187	Target Neighborhood Hits	446	Shared Neighborhood Hits	30
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SRGP1_HUMAN
NC score	0.079391 (rank : 169)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	187	Target Neighborhood Hits	390	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FYCO1_MOUSE
NC score	0.078665 (rank : 170)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	187	Target Neighborhood Hits	1059	Shared Neighborhood Hits	67
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

FNBP2_HUMAN
NC score	0.077800 (rank : 171)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	187	Target Neighborhood Hits	432	Shared Neighborhood Hits	41
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

AHI1_MOUSE
NC score	0.077791 (rank : 172)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	187	Target Neighborhood Hits	496	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

SRGP2_MOUSE
NC score	0.077492 (rank : 173)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	187	Target Neighborhood Hits	324	Shared Neighborhood Hits	37
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SPTA1_HUMAN
NC score	0.077229 (rank : 174)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	187	Target Neighborhood Hits	748	Shared Neighborhood Hits	66
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SWP70_MOUSE
NC score	0.076831 (rank : 175)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	187	Target Neighborhood Hits	1097	Shared Neighborhood Hits	75
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RHG26_HUMAN
NC score	0.076784 (rank : 176)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	187	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SRGP2_HUMAN
NC score	0.076742 (rank : 177)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	187	Target Neighborhood Hits	331	Shared Neighborhood Hits	37
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SPTA1_MOUSE
NC score	0.076543 (rank : 178)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	187	Target Neighborhood Hits	675	Shared Neighborhood Hits	59
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

GOGA4_HUMAN
NC score	0.075964 (rank : 179)	θ value	0.00298849 (rank : 70)
Query Neighborhood Hits	187	Target Neighborhood Hits	2034	Shared Neighborhood Hits	83
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

ZFY19_HUMAN
NC score	0.075883 (rank : 180)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	187	Target Neighborhood Hits	206	Shared Neighborhood Hits	20
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

NOXO1_HUMAN
NC score	0.075577 (rank : 181)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	187	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

OBSCN_HUMAN
NC score	0.075562 (rank : 182)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	187	Target Neighborhood Hits	1931	Shared Neighborhood Hits	64
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PLCG2_HUMAN
NC score	0.074963 (rank : 183)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	187	Target Neighborhood Hits	280	Shared Neighborhood Hits	17
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PEX13_MOUSE
NC score	0.074779 (rank : 184)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	187	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ANM2_HUMAN
NC score	0.074327 (rank : 185)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SWP70_HUMAN
NC score	0.074134 (rank : 186)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	187	Target Neighborhood Hits	973	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

FYCO1_HUMAN
NC score	0.074116 (rank : 187)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	187	Target Neighborhood Hits	1149	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

PACN2_HUMAN
NC score	0.073186 (rank : 188)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	187	Target Neighborhood Hits	339	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RILP_HUMAN
NC score	0.072648 (rank : 189)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	187	Target Neighborhood Hits	249	Shared Neighborhood Hits	17
SwissProt Accessions	Q96NA2, Q71RE6, Q9BSL3, Q9BYS3	Gene names	RILP
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

NPHP1_HUMAN
NC score	0.072568 (rank : 190)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	187	Target Neighborhood Hits	288	Shared Neighborhood Hits	33
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PEX13_HUMAN
NC score	0.072307 (rank : 191)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	187	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PACN2_MOUSE
NC score	0.072101 (rank : 192)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	187	Target Neighborhood Hits	382	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

LMO7_HUMAN
NC score	0.070545 (rank : 193)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	187	Target Neighborhood Hits	507	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

CT032_HUMAN
NC score	0.070434 (rank : 194)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	187	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

GOGA4_MOUSE
NC score	0.070232 (rank : 195)	θ value	0.0330416 (rank : 73)
Query Neighborhood Hits	187	Target Neighborhood Hits	1939	Shared Neighborhood Hits	74
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ZFYV1_HUMAN
NC score	0.069814 (rank : 196)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	187	Target Neighborhood Hits	166	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

EP15R_MOUSE
NC score	0.069790 (rank : 197)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	187	Target Neighborhood Hits	1135	Shared Neighborhood Hits	56
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

ANM2_MOUSE
NC score	0.069489 (rank : 198)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

EP15R_HUMAN
NC score	0.069365 (rank : 199)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	187	Target Neighborhood Hits	1083	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

ZFY19_MOUSE
NC score	0.069032 (rank : 200)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	187	Target Neighborhood Hits	143	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

RILP_MOUSE
NC score	0.068964 (rank : 201)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	187	Target Neighborhood Hits	257	Shared Neighborhood Hits	19
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

PKHA6_MOUSE
NC score	0.068864 (rank : 202)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	187	Target Neighborhood Hits	591	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PACN3_HUMAN
NC score	0.068729 (rank : 203)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	187	Target Neighborhood Hits	385	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

BI2L1_MOUSE
NC score	0.068691 (rank : 204)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	187	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PACN3_MOUSE
NC score	0.068358 (rank : 205)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	187	Target Neighborhood Hits	380	Shared Neighborhood Hits	41
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PIBF1_HUMAN
NC score	0.067868 (rank : 206)	θ value	0.365318 (rank : 84)
Query Neighborhood Hits	187	Target Neighborhood Hits	1041	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

RIMB2_MOUSE
NC score	0.067839 (rank : 207)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	187	Target Neighborhood Hits	246	Shared Neighborhood Hits	24
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ZFYV1_MOUSE
NC score	0.067821 (rank : 208)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	187	Target Neighborhood Hits	153	Shared Neighborhood Hits	16
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

BCAR1_MOUSE
NC score	0.067651 (rank : 209)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	187	Target Neighborhood Hits	438	Shared Neighborhood Hits	26
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

REPS2_MOUSE
NC score	0.067438 (rank : 210)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	187	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_HUMAN
NC score	0.067341 (rank : 211)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	187	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

MAP1A_HUMAN
NC score	0.067108 (rank : 212)	θ value	0.00665767 (rank : 72)
Query Neighborhood Hits	187	Target Neighborhood Hits	1626	Shared Neighborhood Hits	76
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

CASL_HUMAN
NC score	0.066824 (rank : 213)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	187	Target Neighborhood Hits	259	Shared Neighborhood Hits	23
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

LASP1_HUMAN
NC score	0.066800 (rank : 214)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SHAN1_HUMAN
NC score	0.066708 (rank : 215)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	187	Target Neighborhood Hits	1041	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

FYV1_HUMAN
NC score	0.066673 (rank : 216)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	187	Target Neighborhood Hits	217	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

PACN1_HUMAN
NC score	0.065744 (rank : 217)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	187	Target Neighborhood Hits	320	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

P85A_HUMAN
NC score	0.065415 (rank : 218)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	187	Target Neighborhood Hits	479	Shared Neighborhood Hits	41
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BCAR1_HUMAN
NC score	0.065265 (rank : 219)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	187	Target Neighborhood Hits	554	Shared Neighborhood Hits	29
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

LASP1_MOUSE
NC score	0.064982 (rank : 220)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ASPP1_MOUSE
NC score	0.064923 (rank : 221)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	187	Target Neighborhood Hits	1244	Shared Neighborhood Hits	71
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

EP15_HUMAN
NC score	0.064907 (rank : 222)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	187	Target Neighborhood Hits	1021	Shared Neighborhood Hits	54
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

PKHA6_HUMAN
NC score	0.064803 (rank : 223)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	187	Target Neighborhood Hits	556	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

FYV1_MOUSE
NC score	0.064445 (rank : 224)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	187	Target Neighborhood Hits	191	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

EP15_MOUSE
NC score	0.064441 (rank : 225)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	187	Target Neighborhood Hits	820	Shared Neighborhood Hits	47
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

PACN1_MOUSE
NC score	0.064393 (rank : 226)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	187	Target Neighborhood Hits	283	Shared Neighborhood Hits	27
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

INVO_HUMAN
NC score	0.064338 (rank : 227)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	187	Target Neighborhood Hits	636	Shared Neighborhood Hits	49
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

RBP1_HUMAN
NC score	0.064267 (rank : 228)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	187	Target Neighborhood Hits	521	Shared Neighborhood Hits	37
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RIMB1_MOUSE
NC score	0.064233 (rank : 229)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	187	Target Neighborhood Hits	1376	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
NC score	0.064163 (rank : 230)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	187	Target Neighborhood Hits	263	Shared Neighborhood Hits	17
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CASL_MOUSE
NC score	0.062166 (rank : 231)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	187	Target Neighborhood Hits	225	Shared Neighborhood Hits	23
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

EFS_MOUSE
NC score	0.062128 (rank : 232)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	187	Target Neighborhood Hits	389	Shared Neighborhood Hits	25
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

RIMB1_HUMAN
NC score	0.061987 (rank : 233)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	187	Target Neighborhood Hits	1479	Shared Neighborhood Hits	76
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

AZI1_MOUSE
NC score	0.061643 (rank : 234)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	187	Target Neighborhood Hits	990	Shared Neighborhood Hits	59
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

GRP3_HUMAN
NC score	0.061626 (rank : 235)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	187	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

REPS1_MOUSE
NC score	0.061262 (rank : 236)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	187	Target Neighborhood Hits	204	Shared Neighborhood Hits	9
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

GOGA3_MOUSE
NC score	0.060567 (rank : 237)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	187	Target Neighborhood Hits	1437	Shared Neighborhood Hits	69
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

NEBU_HUMAN
NC score	0.060300 (rank : 238)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	187	Target Neighborhood Hits	420	Shared Neighborhood Hits	33
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

P85B_HUMAN
NC score	0.059856 (rank : 239)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	187	Target Neighborhood Hits	543	Shared Neighborhood Hits	36
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CCD46_MOUSE
NC score	0.059856 (rank : 240)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	187	Target Neighborhood Hits	1405	Shared Neighborhood Hits	71
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

TRIPB_HUMAN
NC score	0.059488 (rank : 241)	θ value	6.88961 (rank : 164)
Query Neighborhood Hits	187	Target Neighborhood Hits	1587	Shared Neighborhood Hits	77
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

CCD46_HUMAN
NC score	0.059331 (rank : 242)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	187	Target Neighborhood Hits	1430	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

RBP1_MOUSE
NC score	0.059281 (rank : 243)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	187	Target Neighborhood Hits	493	Shared Neighborhood Hits	36
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

P85A_MOUSE
NC score	0.059258 (rank : 244)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	187	Target Neighborhood Hits	435	Shared Neighborhood Hits	34
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CE290_HUMAN
NC score	0.058852 (rank : 245)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	187	Target Neighborhood Hits	1553	Shared Neighborhood Hits	69
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

WDFY3_HUMAN
NC score	0.058657 (rank : 246)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	187	Target Neighborhood Hits	348	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

CENPF_HUMAN
NC score	0.058528 (rank : 247)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	187	Target Neighborhood Hits	1932	Shared Neighborhood Hits	77
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

GOGB1_HUMAN
NC score	0.058467 (rank : 248)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	187	Target Neighborhood Hits	2297	Shared Neighborhood Hits	85
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

WDFY1_HUMAN
NC score	0.058351 (rank : 249)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	187	Target Neighborhood Hits	305	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

MYO1F_MOUSE
NC score	0.058330 (rank : 250)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	187	Target Neighborhood Hits	262	Shared Neighborhood Hits	32
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ASPP1_HUMAN
NC score	0.058203 (rank : 251)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	187	Target Neighborhood Hits	956	Shared Neighborhood Hits	58
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

WDFY3_MOUSE
NC score	0.058177 (rank : 252)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	187	Target Neighborhood Hits	332	Shared Neighborhood Hits	19
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

MYO1F_HUMAN
NC score	0.057785 (rank : 253)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	187	Target Neighborhood Hits	275	Shared Neighborhood Hits	34
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

CK5P2_MOUSE
NC score	0.057505 (rank : 254)	θ value	0.0961366 (rank : 77)
Query Neighborhood Hits	187	Target Neighborhood Hits	1151	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

FLIP1_HUMAN
NC score	0.057497 (rank : 255)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	187	Target Neighborhood Hits	1405	Shared Neighborhood Hits	73
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

EFS_HUMAN
NC score	0.057062 (rank : 256)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	187	Target Neighborhood Hits	348	Shared Neighborhood Hits	21
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

MYO1E_HUMAN
NC score	0.056725 (rank : 257)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	33
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

AZI1_HUMAN
NC score	0.056661 (rank : 258)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	187	Target Neighborhood Hits	1000	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CE152_HUMAN
NC score	0.056608 (rank : 259)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	187	Target Neighborhood Hits	976	Shared Neighborhood Hits	56
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

IFT81_MOUSE
NC score	0.056373 (rank : 260)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	187	Target Neighborhood Hits	959	Shared Neighborhood Hits	54
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CN145_HUMAN
NC score	0.056331 (rank : 261)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	187	Target Neighborhood Hits	1196	Shared Neighborhood Hits	58
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

AKAP9_HUMAN
NC score	0.056293 (rank : 262)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	187	Target Neighborhood Hits	1710	Shared Neighborhood Hits	73
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

BAIP2_MOUSE
NC score	0.056247 (rank : 263)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	187	Target Neighborhood Hits	185	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

P85B_MOUSE
NC score	0.056150 (rank : 264)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	187	Target Neighborhood Hits	519	Shared Neighborhood Hits	36
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TOPB1_MOUSE
NC score	0.056129 (rank : 265)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	187	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).

REPS1_HUMAN
NC score	0.056021 (rank : 266)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	187	Target Neighborhood Hits	205	Shared Neighborhood Hits	8
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

CCD41_HUMAN
NC score	0.056018 (rank : 267)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	187	Target Neighborhood Hits	1139	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

IASPP_MOUSE
NC score	0.055982 (rank : 268)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	187	Target Neighborhood Hits	1024	Shared Neighborhood Hits	36
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CCD96_MOUSE
NC score	0.055720 (rank : 269)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	187	Target Neighborhood Hits	704	Shared Neighborhood Hits	49
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CP250_HUMAN
NC score	0.055716 (rank : 270)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	187	Target Neighborhood Hits	1805	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CK5P2_HUMAN
NC score	0.055586 (rank : 271)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	187	Target Neighborhood Hits	1433	Shared Neighborhood Hits	70
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

TOPB1_HUMAN
NC score	0.055562 (rank : 272)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	187	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q92547, Q7LGC1, Q9UEB9	Gene names	TOPBP1, KIAA0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-binding protein 1) (DNA topoisomerase IIbeta-binding protein 1) (TopBP1).

RHG25_HUMAN
NC score	0.055533 (rank : 273)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	187	Target Neighborhood Hits	550	Shared Neighborhood Hits	49
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ASPP2_HUMAN
NC score	0.055447 (rank : 274)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	187	Target Neighborhood Hits	1156	Shared Neighborhood Hits	56
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAIP2_HUMAN
NC score	0.055440 (rank : 275)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	187	Target Neighborhood Hits	192	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

IASPP_HUMAN
NC score	0.055248 (rank : 276)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	187	Target Neighborhood Hits	688	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

U2AFL_HUMAN
NC score	0.055187 (rank : 277)	θ value	0.47712 (rank : 89)
Query Neighborhood Hits	187	Target Neighborhood Hits	503	Shared Neighborhood Hits	47
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

TUFT1_HUMAN
NC score	0.054985 (rank : 278)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	187	Target Neighborhood Hits	686	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

CCD41_MOUSE
NC score	0.054750 (rank : 279)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	187	Target Neighborhood Hits	1399	Shared Neighborhood Hits	63
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CAR11_HUMAN
NC score	0.054552 (rank : 280)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	187	Target Neighborhood Hits	690	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CCD91_HUMAN
NC score	0.054227 (rank : 281)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	187	Target Neighborhood Hits	868	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

LUZP1_MOUSE
NC score	0.054213 (rank : 282)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	187	Target Neighborhood Hits	940	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

RAD50_HUMAN
NC score	0.054004 (rank : 283)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	187	Target Neighborhood Hits	1317	Shared Neighborhood Hits	67
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

SYNE1_HUMAN
NC score	0.054001 (rank : 284)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	187	Target Neighborhood Hits	1484	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

GCC2_HUMAN
NC score	0.053942 (rank : 285)	θ value	4.03905 (rank : 130)
Query Neighborhood Hits	187	Target Neighborhood Hits	1558	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

DDEF2_HUMAN
NC score	0.053831 (rank : 286)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	187	Target Neighborhood Hits	599	Shared Neighborhood Hits	35
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

TPR_HUMAN
NC score	0.053824 (rank : 287)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	187	Target Neighborhood Hits	1921	Shared Neighborhood Hits	79
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CCD13_HUMAN
NC score	0.053615 (rank : 288)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	187	Target Neighborhood Hits	721	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

MD1L1_MOUSE
NC score	0.053513 (rank : 289)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	187	Target Neighborhood Hits	1001	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

DESP_HUMAN
NC score	0.053467 (rank : 290)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	187	Target Neighborhood Hits	1470	Shared Neighborhood Hits	69
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

RBP24_HUMAN
NC score	0.053462 (rank : 291)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	187	Target Neighborhood Hits	1559	Shared Neighborhood Hits	67
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

FA50A_MOUSE
NC score	0.053425 (rank : 292)	θ value	0.47712 (rank : 86)
Query Neighborhood Hits	187	Target Neighborhood Hits	293	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

CEP63_HUMAN
NC score	0.053418 (rank : 293)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	187	Target Neighborhood Hits	1005	Shared Neighborhood Hits	60
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

DDEF2_MOUSE
NC score	0.053417 (rank : 294)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	187	Target Neighborhood Hits	625	Shared Neighborhood Hits	30
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CN145_MOUSE
NC score	0.053353 (rank : 295)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	187	Target Neighborhood Hits	916	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

SYCP1_MOUSE
NC score	0.053040 (rank : 296)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	187	Target Neighborhood Hits	1456	Shared Neighborhood Hits	68
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

RHG25_MOUSE
NC score	0.053004 (rank : 297)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	187	Target Neighborhood Hits	492	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MTMR3_HUMAN
NC score	0.052955 (rank : 298)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	187	Target Neighborhood Hits	163	Shared Neighborhood Hits	15
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

SNX18_MOUSE
NC score	0.052908 (rank : 299)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	187	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

GCC2_MOUSE
NC score	0.052895 (rank : 300)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	187	Target Neighborhood Hits	1619	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

CP250_MOUSE
NC score	0.052766 (rank : 301)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	187	Target Neighborhood Hits	1583	Shared Neighborhood Hits	68
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CCD91_MOUSE
NC score	0.052697 (rank : 302)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	187	Target Neighborhood Hits	699	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

NUMA1_HUMAN
NC score	0.052660 (rank : 303)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	187	Target Neighborhood Hits	1523	Shared Neighborhood Hits	70
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

CCD19_HUMAN
NC score	0.052608 (rank : 304)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	187	Target Neighborhood Hits	639	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

IF3A_MOUSE
NC score	0.052604 (rank : 305)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	187	Target Neighborhood Hits	871	Shared Neighborhood Hits	58
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

RAD50_MOUSE
NC score	0.052552 (rank : 306)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	187	Target Neighborhood Hits	1366	Shared Neighborhood Hits	66
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

IFT74_HUMAN
NC score	0.052528 (rank : 307)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	187	Target Neighborhood Hits	949	Shared Neighborhood Hits	52
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

CI093_HUMAN
NC score	0.052432 (rank : 308)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	187	Target Neighborhood Hits	1088	Shared Neighborhood Hits	58
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

GRAP1_MOUSE
NC score	0.052393 (rank : 309)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	187	Target Neighborhood Hits	1234	Shared Neighborhood Hits	65
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

CDR2_MOUSE
NC score	0.052380 (rank : 310)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	187	Target Neighborhood Hits	482	Shared Neighborhood Hits	40
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

RFIP3_HUMAN
NC score	0.052297 (rank : 311)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	187	Target Neighborhood Hits	1055	Shared Neighborhood Hits	55
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

HMMR_HUMAN
NC score	0.052296 (rank : 312)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	187	Target Neighborhood Hits	1082	Shared Neighborhood Hits	59
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

PCNT_HUMAN
NC score	0.052035 (rank : 313)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	187	Target Neighborhood Hits	1551	Shared Neighborhood Hits	72
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

MACF4_HUMAN
NC score	0.052018 (rank : 314)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	187	Target Neighborhood Hits	1321	Shared Neighborhood Hits	65
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

INCE_HUMAN
NC score	0.051785 (rank : 315)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	187	Target Neighborhood Hits	978	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

RABE1_HUMAN
NC score	0.051714 (rank : 316)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	187	Target Neighborhood Hits	1104	Shared Neighborhood Hits	61
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

NIN_MOUSE
NC score	0.051579 (rank : 317)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	187	Target Neighborhood Hits	1376	Shared Neighborhood Hits	59
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

IF3A_HUMAN
NC score	0.051475 (rank : 318)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	187	Target Neighborhood Hits	875	Shared Neighborhood Hits	57
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

CNTRB_MOUSE
NC score	0.051414 (rank : 319)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	187	Target Neighborhood Hits	1029	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP135_MOUSE
NC score	0.051400 (rank : 320)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	187	Target Neighborhood Hits	1278	Shared Neighborhood Hits	61
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

TRHY_HUMAN
NC score	0.051195 (rank : 321)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	187	Target Neighborhood Hits	1385	Shared Neighborhood Hits	57
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

CAF1A_MOUSE
NC score	0.051184 (rank : 322)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	187	Target Neighborhood Hits	736	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

SNX18_HUMAN
NC score	0.051104 (rank : 323)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	187	Target Neighborhood Hits	207	Shared Neighborhood Hits	18
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CEP55_MOUSE
NC score	0.051046 (rank : 324)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	187	Target Neighborhood Hits	693	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

PCNT_MOUSE
NC score	0.051016 (rank : 325)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	187	Target Neighborhood Hits	1207	Shared Neighborhood Hits	65
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

DDEF1_MOUSE
NC score	0.050950 (rank : 326)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	187	Target Neighborhood Hits	592	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CU013_HUMAN
NC score	0.050928 (rank : 327)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	187	Target Neighborhood Hits	405	Shared Neighborhood Hits	37
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

OPTN_MOUSE
NC score	0.050851 (rank : 328)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	187	Target Neighborhood Hits	1120	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

OPTN_HUMAN
NC score	0.050835 (rank : 329)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	187	Target Neighborhood Hits	827	Shared Neighborhood Hits	57
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

CF060_HUMAN
NC score	0.050776 (rank : 330)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	187	Target Neighborhood Hits	1270	Shared Neighborhood Hits	59
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

KMHN1_MOUSE
NC score	0.050683 (rank : 331)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	187	Target Neighborhood Hits	949	Shared Neighborhood Hits	60
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

MD1L1_HUMAN
NC score	0.050664 (rank : 332)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	187	Target Neighborhood Hits	893	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

CING_MOUSE
NC score	0.050384 (rank : 333)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	187	Target Neighborhood Hits	1432	Shared Neighborhood Hits	64
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

REST_HUMAN
NC score	0.050260 (rank : 334)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	187	Target Neighborhood Hits	1605	Shared Neighborhood Hits	67
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RB6I2_HUMAN
NC score	0.050211 (rank : 335)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	187	Target Neighborhood Hits	1584	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

FLIP1_MOUSE
NC score	0.050126 (rank : 336)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	187	Target Neighborhood Hits	1176	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

ANR26_MOUSE
NC score	0.049966 (rank : 337)	θ value	0.279714 (rank : 81)
Query Neighborhood Hits	187	Target Neighborhood Hits	1554	Shared Neighborhood Hits	66
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

K1688_HUMAN
NC score	0.048456 (rank : 338)	θ value	0.163984 (rank : 78)
Query Neighborhood Hits	187	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

FA50A_HUMAN
NC score	0.048242 (rank : 339)	θ value	3.0926 (rank : 118)
Query Neighborhood Hits	187	Target Neighborhood Hits	264	Shared Neighborhood Hits	34
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

MYH6_MOUSE
NC score	0.048081 (rank : 340)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	187	Target Neighborhood Hits	1501	Shared Neighborhood Hits	67
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH8_HUMAN
NC score	0.047161 (rank : 341)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	187	Target Neighborhood Hits	1610	Shared Neighborhood Hits	70
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH7_HUMAN
NC score	0.046485 (rank : 342)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	187	Target Neighborhood Hits	1559	Shared Neighborhood Hits	72
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

CDCA4_MOUSE
NC score	0.046280 (rank : 343)	θ value	0.0961366 (rank : 76)
Query Neighborhood Hits	187	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWM2, Q3U1C0, Q921E8, Q99MP6	Gene names	Cdca4, Hepp
Domain Architecture
Description	Cell division cycle-associated protein 4 (Hematopoietic progenitor protein).

MYH8_MOUSE
NC score	0.046066 (rank : 344)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	187	Target Neighborhood Hits	1600	Shared Neighborhood Hits	74
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH9_HUMAN
NC score	0.045873 (rank : 345)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	187	Target Neighborhood Hits	1762	Shared Neighborhood Hits	76
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RPGR1_HUMAN
NC score	0.045814 (rank : 346)	θ value	2.36792 (rank : 115)
Query Neighborhood Hits	187	Target Neighborhood Hits	578	Shared Neighborhood Hits	43
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

MYH6_HUMAN
NC score	0.045669 (rank : 347)	θ value	8.99809 (rank : 178)
Query Neighborhood Hits	187	Target Neighborhood Hits	1426	Shared Neighborhood Hits	68
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH4_MOUSE
NC score	0.045204 (rank : 348)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	187	Target Neighborhood Hits	1476	Shared Neighborhood Hits	69
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH9_MOUSE
NC score	0.044769 (rank : 349)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	187	Target Neighborhood Hits	1829	Shared Neighborhood Hits	70
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MACF1_HUMAN
NC score	0.044513 (rank : 350)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	187	Target Neighborhood Hits	1341	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

SPTB2_MOUSE
NC score	0.044395 (rank : 351)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	187	Target Neighborhood Hits	770	Shared Neighborhood Hits	54
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

IF2P_HUMAN
NC score	0.043247 (rank : 352)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	187	Target Neighborhood Hits	889	Shared Neighborhood Hits	50
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

MYH4_HUMAN
NC score	0.042172 (rank : 353)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	187	Target Neighborhood Hits	1377	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

CENPH_MOUSE
NC score	0.038691 (rank : 354)	θ value	4.03905 (rank : 129)
Query Neighborhood Hits	187	Target Neighborhood Hits	195	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QYM8, Q8R3K9, Q9D079, Q9D0N1	Gene names	Cenph, Enp
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H).

K1688_MOUSE
NC score	0.038025 (rank : 355)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	187	Target Neighborhood Hits	188	Shared Neighborhood Hits	7
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

SAFB2_HUMAN
NC score	0.037835 (rank : 356)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	187	Target Neighborhood Hits	720	Shared Neighborhood Hits	46
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

NFM_HUMAN
NC score	0.035242 (rank : 357)	θ value	1.38821 (rank : 107)
Query Neighborhood Hits	187	Target Neighborhood Hits	1328	Shared Neighborhood Hits	68
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

CTRO_MOUSE
NC score	0.034428 (rank : 358)	θ value	0.279714 (rank : 82)
Query Neighborhood Hits	187	Target Neighborhood Hits	2344	Shared Neighborhood Hits	75
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

BCDO1_MOUSE
NC score	0.033992 (rank : 359)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	187	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JJS6, Q6K1L5, Q8C6N5, Q9ERN9	Gene names	Bcmo1, Bcdo, Bcdo1
Domain Architecture
Description	Beta,beta-carotene 15,15'-monooxygenase (EC 1.14.99.36) (Beta-carotene dioxygenase 1).

AKAP6_HUMAN
NC score	0.033723 (rank : 360)	θ value	3.0926 (rank : 116)
Query Neighborhood Hits	187	Target Neighborhood Hits	263	Shared Neighborhood Hits	25
SwissProt Accessions	Q13023, O15028	Gene names	AKAP6, AKAP100, KIAA0311
Domain Architecture
Description	A-kinase anchor protein 6 (Protein kinase A-anchoring protein 6) (PRKA6) (A-kinase anchor protein 100 kDa) (AKAP 100) (mAKAP).

LMNA_MOUSE
NC score	0.032881 (rank : 361)	θ value	3.0926 (rank : 121)
Query Neighborhood Hits	187	Target Neighborhood Hits	661	Shared Neighborhood Hits	46
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

LMNA_HUMAN
NC score	0.032558 (rank : 362)	θ value	3.0926 (rank : 120)
Query Neighborhood Hits	187	Target Neighborhood Hits	653	Shared Neighborhood Hits	43
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

NFM_MOUSE
NC score	0.032109 (rank : 363)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	187	Target Neighborhood Hits	1159	Shared Neighborhood Hits	61
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

ANR21_HUMAN
NC score	0.031958 (rank : 364)	θ value	0.279714 (rank : 80)
Query Neighborhood Hits	187	Target Neighborhood Hits	864	Shared Neighborhood Hits	48
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

CCDC9_HUMAN
NC score	0.031798 (rank : 365)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	187	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

POT15_HUMAN
NC score	0.031262 (rank : 366)	θ value	0.279714 (rank : 83)
Query Neighborhood Hits	187	Target Neighborhood Hits	893	Shared Neighborhood Hits	46
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

SDC3_MOUSE
NC score	0.031149 (rank : 367)	θ value	0.47712 (rank : 87)
Query Neighborhood Hits	187	Target Neighborhood Hits	107	Shared Neighborhood Hits	4
SwissProt Accessions	Q64519, Q3UDD9, Q6ZQA4, Q7TQD4	Gene names	Sdc3, Kiaa0468
Domain Architecture
Description	Syndecan-3 precursor (SYND3).

BCDO1_HUMAN
NC score	0.030490 (rank : 368)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	187	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAY6, Q9NVH5	Gene names	BCMO1, BCDO, BCDO1
Domain Architecture
Description	Beta,beta-carotene 15,15'-monooxygenase (EC 1.14.99.36) (Beta-carotene dioxygenase 1).

SAFB1_HUMAN
NC score	0.030041 (rank : 369)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	187	Target Neighborhood Hits	493	Shared Neighborhood Hits	40
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

YTDC1_HUMAN
NC score	0.029874 (rank : 370)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	187	Target Neighborhood Hits	458	Shared Neighborhood Hits	28
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

GLU2B_HUMAN
NC score	0.027630 (rank : 371)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	187	Target Neighborhood Hits	377	Shared Neighborhood Hits	26
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

TAOK1_HUMAN
NC score	0.026301 (rank : 372)	θ value	0.47712 (rank : 88)
Query Neighborhood Hits	187	Target Neighborhood Hits	1734	Shared Neighborhood Hits	61
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
NC score	0.025181 (rank : 373)	θ value	0.62314 (rank : 90)
Query Neighborhood Hits	187	Target Neighborhood Hits	1720	Shared Neighborhood Hits	60
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

STK10_HUMAN
NC score	0.024833 (rank : 374)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	187	Target Neighborhood Hits	1921	Shared Neighborhood Hits	63
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

IQEC3_HUMAN
NC score	0.024138 (rank : 375)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	187	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

MYST4_HUMAN
NC score	0.021285 (rank : 376)	θ value	1.38821 (rank : 106)
Query Neighborhood Hits	187	Target Neighborhood Hits	671	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

N4BP2_HUMAN
NC score	0.021030 (rank : 377)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	187	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q86UW6, Q9NVK2, Q9P2D4	Gene names	N4BP2, B3BP, KIAA1413
Domain Architecture
Description	NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein).

IQEC3_MOUSE
NC score	0.020309 (rank : 378)	θ value	3.0926 (rank : 119)
Query Neighborhood Hits	187	Target Neighborhood Hits	274	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

K0100_HUMAN
NC score	0.020251 (rank : 379)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	187	Target Neighborhood Hits	132	Shared Neighborhood Hits	19
SwissProt Accessions	Q14667, Q3SYN5, Q49A07, Q5H9T4, Q6WG74, Q6ZP51, Q96HH8	Gene names	KIAA0100, BCOX1
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor (Breast cancer overexpressed gene 1 protein) (Antigen MLAA-22).

PAR3L_HUMAN
NC score	0.019500 (rank : 380)	θ value	3.0926 (rank : 124)
Query Neighborhood Hits	187	Target Neighborhood Hits	297	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

IF38_HUMAN
NC score	0.018241 (rank : 381)	θ value	4.03905 (rank : 132)
Query Neighborhood Hits	187	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q99613, O00215	Gene names	EIF3S8
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 8 (eIF3 p110) (eIF3c).

MADCA_HUMAN
NC score	0.018047 (rank : 382)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	187	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

GA2L3_HUMAN
NC score	0.017583 (rank : 383)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	187	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q86XJ1	Gene names	GAS2L3
Domain Architecture	No domain graphic available
Description	GAS2-like protein 3 (Growth arrest-specific 2-like 3).

CHD3_HUMAN
NC score	0.017485 (rank : 384)	θ value	0.21417 (rank : 79)
Query Neighborhood Hits	187	Target Neighborhood Hits	397	Shared Neighborhood Hits	13
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

UB2Q1_HUMAN
NC score	0.016999 (rank : 385)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	187	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z7E8, Q3B841, Q5I0X2, Q6IS04, Q6P7P2, Q96MV4, Q9BVX5, Q9UGL6	Gene names	UBE2Q1, NICE5, UBE2Q
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19) (Ubiquitin-protein ligase Q1) (Ubiquitin carrier protein Q1) (Protein NICE-5).

SET1A_HUMAN
NC score	0.016975 (rank : 386)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	187	Target Neighborhood Hits	690	Shared Neighborhood Hits	23
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

DHX37_HUMAN
NC score	0.016834 (rank : 387)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	187	Target Neighborhood Hits	133	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY37, Q9BUI7, Q9P211	Gene names	DHX37, DDX37, KIAA1517
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.1.-) (DEAH box protein 37).

UB2Q1_MOUSE
NC score	0.016332 (rank : 388)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	187	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSS2, Q3UIY3, Q6P913, Q80UT5, Q8K2T0, Q9D7E1	Gene names	Ube2q1, Ube2q
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19) (Ubiquitin-protein ligase Q1) (Ubiquitin carrier protein Q1).

TRI44_MOUSE
NC score	0.015983 (rank : 389)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	187	Target Neighborhood Hits	327	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

CHD5_HUMAN
NC score	0.015840 (rank : 390)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	187	Target Neighborhood Hits	349	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

OXRP_HUMAN
NC score	0.015721 (rank : 391)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	187	Target Neighborhood Hits	544	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

SV2A_HUMAN
NC score	0.015457 (rank : 392)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	187	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q7L0J3, O94841, Q5QNX8, Q7Z3L6, Q8NBJ6, Q9BVZ9	Gene names	SV2A, KIAA0736
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2A.

SSH2_HUMAN
NC score	0.015398 (rank : 393)	θ value	0.365318 (rank : 85)
Query Neighborhood Hits	187	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

H6ST3_HUMAN
NC score	0.014830 (rank : 394)	θ value	4.03905 (rank : 131)
Query Neighborhood Hits	187	Target Neighborhood Hits	66	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IZP7, Q5W0L0, Q68CW6	Gene names	HS6ST3
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 3 (EC 2.8.2.-) (HS6ST-3).

ZO1_MOUSE
NC score	0.014328 (rank : 395)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	187	Target Neighborhood Hits	453	Shared Neighborhood Hits	12
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

K1C20_HUMAN
NC score	0.014232 (rank : 396)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	187	Target Neighborhood Hits	468	Shared Neighborhood Hits	35
SwissProt Accessions	P35900	Gene names	KRT20
Domain Architecture
Description	Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT).

SV2A_MOUSE
NC score	0.014074 (rank : 397)	θ value	3.0926 (rank : 126)
Query Neighborhood Hits	187	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIS5, Q80TT0, Q8R0R5	Gene names	Sv2a, Kiaa0736, Sv2
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2A (Synaptic vesicle protein 2A) (Synaptic vesicle protein 2) (Calcium regulator SV2A).

ARI3A_HUMAN
NC score	0.014017 (rank : 398)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	187	Target Neighborhood Hits	80	Shared Neighborhood Hits	6
SwissProt Accessions	Q99856, Q8IZA7	Gene names	ARID3A, DRIL1, DRX, E2FBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (E2F-binding protein 1).

SPAG1_MOUSE
NC score	0.013810 (rank : 399)	θ value	1.38821 (rank : 108)
Query Neighborhood Hits	187	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	Q80ZX8, Q8CCK7, Q9QZJ3, Q9QZJ4	Gene names	Spag1, Tpis
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS).

JADE2_MOUSE
NC score	0.013479 (rank : 400)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	187	Target Neighborhood Hits	560	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

CF058_HUMAN
NC score	0.012910 (rank : 401)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	187	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P5S2, Q5VUP2	Gene names	C6orf58
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf58 precursor.

FEZ1_MOUSE
NC score	0.012780 (rank : 402)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	187	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K0X8	Gene names	Fez1
Domain Architecture	No domain graphic available
Description	Fasciculation and elongation protein zeta 1 (Zygin-1) (Zygin I).

UBXD6_HUMAN
NC score	0.012741 (rank : 403)	θ value	6.88961 (rank : 165)
Query Neighborhood Hits	187	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	O00124, Q7Z6F2	Gene names	UBXD6, D8S2298E, REP8
Domain Architecture
Description	UBX domain-containing protein 6 (Reproduction 8 protein) (Protein Rep- 8).

CHD4_MOUSE
NC score	0.012524 (rank : 404)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	187	Target Neighborhood Hits	408	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CTNA1_HUMAN
NC score	0.012210 (rank : 405)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	187	Target Neighborhood Hits	83	Shared Neighborhood Hits	16
SwissProt Accessions	P35221, Q12795	Gene names	CTNNA1
Domain Architecture
Description	Catenin alpha-1 (Cadherin-associated protein) (Alpha E-catenin) (NY- REN-13 antigen).

CTNA1_MOUSE
NC score	0.011648 (rank : 406)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	187	Target Neighborhood Hits	84	Shared Neighborhood Hits	15
SwissProt Accessions	P26231	Gene names	Ctnna1, Catna1
Domain Architecture
Description	Catenin alpha-1 (102 kDa cadherin-associated protein) (CAP102) (Alpha E-catenin).

KI13B_HUMAN
NC score	0.010983 (rank : 407)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	187	Target Neighborhood Hits	492	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

RING1_HUMAN
NC score	0.010214 (rank : 408)	θ value	3.0926 (rank : 125)
Query Neighborhood Hits	187	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

MAGE1_HUMAN
NC score	0.009219 (rank : 409)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	187	Target Neighborhood Hits	1389	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SAPS1_MOUSE
NC score	0.009097 (rank : 410)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	187	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

BIG2_HUMAN
NC score	0.008749 (rank : 411)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	187	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

TCAL3_MOUSE
NC score	0.008712 (rank : 412)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	187	Target Neighborhood Hits	132	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R0A5, Q9CYK5, Q9D1S4	Gene names	Tceal3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

UBP42_HUMAN
NC score	0.008485 (rank : 413)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	187	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

RING1_MOUSE
NC score	0.007336 (rank : 414)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	187	Target Neighborhood Hits	220	Shared Neighborhood Hits	3
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

NCKX1_HUMAN
NC score	0.007327 (rank : 415)	θ value	8.99809 (rank : 179)
Query Neighborhood Hits	187	Target Neighborhood Hits	223	Shared Neighborhood Hits	10
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

UCP4_HUMAN
NC score	0.007302 (rank : 416)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	187	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	O95847	Gene names	SLC25A27, UCP4
Domain Architecture
Description	Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27).

ANXA6_HUMAN
NC score	0.007211 (rank : 417)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	187	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	P08133, Q6ZT79	Gene names	ANXA6, ANX6
Domain Architecture
Description	Annexin A6 (Annexin VI) (Lipocortin VI) (P68) (P70) (Protein III) (Chromobindin-20) (67 kDa calelectrin) (Calphobindin-II) (CPB-II).

SNX15_MOUSE
NC score	0.006989 (rank : 418)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	187	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WE1	Gene names	Snx15
Domain Architecture	No domain graphic available
Description	Sorting nexin-15.

PP2CG_HUMAN
NC score	0.006916 (rank : 419)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	187	Target Neighborhood Hits	140	Shared Neighborhood Hits	10
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

B3A2_HUMAN
NC score	0.006856 (rank : 420)	θ value	3.0926 (rank : 117)
Query Neighborhood Hits	187	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	P04920, Q45EY5, Q969L3	Gene names	SLC4A2, AE2, EPB3L1, HKB3, MPB3L
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (BND3L).

G3BP2_MOUSE
NC score	0.005744 (rank : 421)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	187	Target Neighborhood Hits	258	Shared Neighborhood Hits	8
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

GSHR_MOUSE
NC score	0.005675 (rank : 422)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	187	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P47791, Q7TNC2, Q8BN97, Q8C9Z6	Gene names	Gsr, Gr1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

NUCL_MOUSE
NC score	0.005586 (rank : 423)	θ value	8.99809 (rank : 180)
Query Neighborhood Hits	187	Target Neighborhood Hits	425	Shared Neighborhood Hits	14
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

STAT4_MOUSE
NC score	0.005206 (rank : 424)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	187	Target Neighborhood Hits	73	Shared Neighborhood Hits	7
SwissProt Accessions	P42228	Gene names	Stat4
Domain Architecture
Description	Signal transducer and activator of transcription 4.

GNAS1_MOUSE
NC score	0.004531 (rank : 425)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	187	Target Neighborhood Hits	651	Shared Neighborhood Hits	14
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

RASD1_MOUSE
NC score	0.002407 (rank : 426)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	187	Target Neighborhood Hits	241	Shared Neighborhood Hits	3
SwissProt Accessions	O35626	Gene names	Rasd1, Dexras1
Domain Architecture
Description	Dexamethasone-induced Ras-related protein 1.

RASD1_HUMAN
NC score	0.001542 (rank : 427)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	187	Target Neighborhood Hits	236	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y272, Q9NYB4	Gene names	RASD1, AGS1, DEXRAS1
Domain Architecture
Description	Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1).

PO2F1_HUMAN
NC score	0.001242 (rank : 428)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	187	Target Neighborhood Hits	426	Shared Neighborhood Hits	6
SwissProt Accessions	P14859, Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1	Gene names	POU2F1, OCT1, OTF1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

PWP1_MOUSE
NC score	0.000939 (rank : 429)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	187	Target Neighborhood Hits	278	Shared Neighborhood Hits	5
SwissProt Accessions	Q99LL5, Q9D6T6	Gene names	Pwp1
Domain Architecture	No domain graphic available
Description	Periodic tryptophan protein 1 homolog.

LMX1B_HUMAN
NC score	0.000120 (rank : 430)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	187	Target Neighborhood Hits	404	Shared Neighborhood Hits	3
SwissProt Accessions	O60663, O75463	Gene names	LMX1B
Domain Architecture
Description	LIM homeobox transcription factor 1 beta (LIM/homeobox protein LMX1B) (LIM-homeobox protein 1.2) (LMX-1.2).

ZAN_MOUSE
NC score	-0.000535 (rank : 431)	θ value	6.88961 (rank : 166)
Query Neighborhood Hits	187	Target Neighborhood Hits	808	Shared Neighborhood Hits	4
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

PLMN_MOUSE
NC score	-0.002024 (rank : 432)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	187	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

ZN518_HUMAN
NC score	-0.002310 (rank : 433)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	187	Target Neighborhood Hits	780	Shared Neighborhood Hits	5
SwissProt Accessions	Q6AHZ1, O15044, Q32MP4	Gene names	ZNF518, KIAA0335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 518.