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Network neighborhood for query Sequence : SRBS1_HUMAN

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SRBS1_HUMAN
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SRBS1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	396	Target Neighborhood Hits	396	Shared Neighborhood Hits	396
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	1.01238e-168 (rank : 2)	NC score	0.934573 (rank : 2)
Query Neighborhood Hits	396	Target Neighborhood Hits	409	Shared Neighborhood Hits	250
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
θ value	1.04822e-48 (rank : 3)	NC score	0.878071 (rank : 3)
Query Neighborhood Hits	396	Target Neighborhood Hits	270	Shared Neighborhood Hits	223
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	2.3352e-48 (rank : 4)	NC score	0.872547 (rank : 4)
Query Neighborhood Hits	396	Target Neighborhood Hits	286	Shared Neighborhood Hits	220
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DNMBP_HUMAN
θ value	7.84624e-12 (rank : 5)	NC score	0.585615 (rank : 23)
Query Neighborhood Hits	396	Target Neighborhood Hits	413	Shared Neighborhood Hits	211
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	2.28291e-11 (rank : 6)	NC score	0.579817 (rank : 25)
Query Neighborhood Hits	396	Target Neighborhood Hits	435	Shared Neighborhood Hits	218
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_HUMAN
θ value	6.64225e-11 (rank : 7)	NC score	0.465032 (rank : 70)
Query Neighborhood Hits	396	Target Neighborhood Hits	1173	Shared Neighborhood Hits	250
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_HUMAN
θ value	2.52405e-10 (rank : 8)	NC score	0.440658 (rank : 80)
Query Neighborhood Hits	396	Target Neighborhood Hits	1757	Shared Neighborhood Hits	286
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
θ value	2.52405e-10 (rank : 9)	NC score	0.443245 (rank : 77)
Query Neighborhood Hits	396	Target Neighborhood Hits	1371	Shared Neighborhood Hits	250
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_MOUSE
θ value	3.29651e-10 (rank : 10)	NC score	0.441262 (rank : 79)
Query Neighborhood Hits	396	Target Neighborhood Hits	1669	Shared Neighborhood Hits	284
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NEBL_HUMAN
θ value	9.59137e-10 (rank : 11)	NC score	0.521906 (rank : 57)
Query Neighborhood Hits	396	Target Neighborhood Hits	457	Shared Neighborhood Hits	197
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

CD2AP_HUMAN
θ value	1.25267e-09 (rank : 12)	NC score	0.695613 (rank : 5)
Query Neighborhood Hits	396	Target Neighborhood Hits	315	Shared Neighborhood Hits	216
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

VAV2_HUMAN
θ value	1.06045e-08 (rank : 13)	NC score	0.491721 (rank : 64)
Query Neighborhood Hits	396	Target Neighborhood Hits	453	Shared Neighborhood Hits	193
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	1.06045e-08 (rank : 14)	NC score	0.492672 (rank : 63)
Query Neighborhood Hits	396	Target Neighborhood Hits	456	Shared Neighborhood Hits	192
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CD2AP_MOUSE
θ value	1.38499e-08 (rank : 15)	NC score	0.687677 (rank : 7)
Query Neighborhood Hits	396	Target Neighborhood Hits	336	Shared Neighborhood Hits	219
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3G2_HUMAN
θ value	1.38499e-08 (rank : 16)	NC score	0.623310 (rank : 11)
Query Neighborhood Hits	396	Target Neighborhood Hits	324	Shared Neighborhood Hits	198
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
θ value	1.80886e-08 (rank : 17)	NC score	0.622634 (rank : 12)
Query Neighborhood Hits	396	Target Neighborhood Hits	222	Shared Neighborhood Hits	189
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3K1_HUMAN
θ value	1.80886e-08 (rank : 18)	NC score	0.691976 (rank : 6)
Query Neighborhood Hits	396	Target Neighborhood Hits	341	Shared Neighborhood Hits	215
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3G1_MOUSE
θ value	2.36244e-08 (rank : 19)	NC score	0.610332 (rank : 14)
Query Neighborhood Hits	396	Target Neighborhood Hits	291	Shared Neighborhood Hits	197
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ARHG7_MOUSE
θ value	3.08544e-08 (rank : 20)	NC score	0.555046 (rank : 36)
Query Neighborhood Hits	396	Target Neighborhood Hits	396	Shared Neighborhood Hits	212
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

SH3G2_MOUSE
θ value	4.0297e-08 (rank : 21)	NC score	0.614049 (rank : 13)
Query Neighborhood Hits	396	Target Neighborhood Hits	319	Shared Neighborhood Hits	199
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3K1_MOUSE
θ value	4.0297e-08 (rank : 22)	NC score	0.685266 (rank : 8)
Query Neighborhood Hits	396	Target Neighborhood Hits	332	Shared Neighborhood Hits	214
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

LASP1_HUMAN
θ value	5.26297e-08 (rank : 23)	NC score	0.547209 (rank : 39)
Query Neighborhood Hits	396	Target Neighborhood Hits	293	Shared Neighborhood Hits	169
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	5.26297e-08 (rank : 24)	NC score	0.547153 (rank : 40)
Query Neighborhood Hits	396	Target Neighborhood Hits	297	Shared Neighborhood Hits	169
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

VAV3_HUMAN
θ value	5.26297e-08 (rank : 25)	NC score	0.468654 (rank : 68)
Query Neighborhood Hits	396	Target Neighborhood Hits	398	Shared Neighborhood Hits	192
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SH3G3_MOUSE
θ value	6.87365e-08 (rank : 26)	NC score	0.630796 (rank : 10)
Query Neighborhood Hits	396	Target Neighborhood Hits	236	Shared Neighborhood Hits	196
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

GRAP_MOUSE
θ value	8.97725e-08 (rank : 27)	NC score	0.573141 (rank : 30)
Query Neighborhood Hits	396	Target Neighborhood Hits	309	Shared Neighborhood Hits	209
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VAV3_MOUSE
θ value	8.97725e-08 (rank : 28)	NC score	0.462492 (rank : 73)
Query Neighborhood Hits	396	Target Neighborhood Hits	404	Shared Neighborhood Hits	188
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SH3G1_HUMAN
θ value	1.17247e-07 (rank : 29)	NC score	0.603128 (rank : 18)
Query Neighborhood Hits	396	Target Neighborhood Hits	307	Shared Neighborhood Hits	197
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ARHG6_MOUSE
θ value	1.53129e-07 (rank : 30)	NC score	0.531917 (rank : 51)
Query Neighborhood Hits	396	Target Neighborhood Hits	394	Shared Neighborhood Hits	202
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

GRAP_HUMAN
θ value	1.53129e-07 (rank : 31)	NC score	0.565197 (rank : 34)
Query Neighborhood Hits	396	Target Neighborhood Hits	307	Shared Neighborhood Hits	202
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ABI1_MOUSE
θ value	1.99992e-07 (rank : 32)	NC score	0.602309 (rank : 19)
Query Neighborhood Hits	396	Target Neighborhood Hits	246	Shared Neighborhood Hits	183
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

GRB2_HUMAN
θ value	4.45536e-07 (rank : 33)	NC score	0.595380 (rank : 20)
Query Neighborhood Hits	396	Target Neighborhood Hits	310	Shared Neighborhood Hits	195
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	4.45536e-07 (rank : 34)	NC score	0.593903 (rank : 21)
Query Neighborhood Hits	396	Target Neighborhood Hits	312	Shared Neighborhood Hits	195
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCK1_HUMAN
θ value	4.45536e-07 (rank : 35)	NC score	0.571048 (rank : 32)
Query Neighborhood Hits	396	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	5.81887e-07 (rank : 36)	NC score	0.572651 (rank : 31)
Query Neighborhood Hits	396	Target Neighborhood Hits	310	Shared Neighborhood Hits	199
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBU_HUMAN
θ value	7.59969e-07 (rank : 37)	NC score	0.441708 (rank : 78)
Query Neighborhood Hits	396	Target Neighborhood Hits	420	Shared Neighborhood Hits	182
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ABI1_HUMAN
θ value	9.92553e-07 (rank : 38)	NC score	0.579442 (rank : 26)
Query Neighborhood Hits	396	Target Neighborhood Hits	257	Shared Neighborhood Hits	181
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PPIP1_HUMAN
θ value	9.92553e-07 (rank : 39)	NC score	0.568325 (rank : 33)
Query Neighborhood Hits	396	Target Neighborhood Hits	389	Shared Neighborhood Hits	203
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ARHG6_HUMAN
θ value	1.29631e-06 (rank : 40)	NC score	0.524777 (rank : 54)
Query Neighborhood Hits	396	Target Neighborhood Hits	376	Shared Neighborhood Hits	203
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

NCF2_HUMAN
θ value	1.29631e-06 (rank : 41)	NC score	0.668850 (rank : 9)
Query Neighborhood Hits	396	Target Neighborhood Hits	229	Shared Neighborhood Hits	179
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SPTA2_HUMAN
θ value	1.69304e-06 (rank : 42)	NC score	0.265131 (rank : 129)
Query Neighborhood Hits	396	Target Neighborhood Hits	888	Shared Neighborhood Hits	197
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

VAV_HUMAN
θ value	1.69304e-06 (rank : 43)	NC score	0.501106 (rank : 61)
Query Neighborhood Hits	396	Target Neighborhood Hits	452	Shared Neighborhood Hits	204
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CRK_MOUSE
θ value	2.21117e-06 (rank : 44)	NC score	0.531429 (rank : 52)
Query Neighborhood Hits	396	Target Neighborhood Hits	314	Shared Neighborhood Hits	192
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

VAV_MOUSE
θ value	2.21117e-06 (rank : 45)	NC score	0.501133 (rank : 60)
Query Neighborhood Hits	396	Target Neighborhood Hits	430	Shared Neighborhood Hits	207
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

STAM1_MOUSE
θ value	2.88788e-06 (rank : 46)	NC score	0.546842 (rank : 41)
Query Neighborhood Hits	396	Target Neighborhood Hits	273	Shared Neighborhood Hits	189
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PPIP1_MOUSE
θ value	3.77169e-06 (rank : 47)	NC score	0.562908 (rank : 35)
Query Neighborhood Hits	396	Target Neighborhood Hits	377	Shared Neighborhood Hits	205
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

NCF4_HUMAN
θ value	4.92598e-06 (rank : 48)	NC score	0.587255 (rank : 22)
Query Neighborhood Hits	396	Target Neighborhood Hits	161	Shared Neighborhood Hits	131
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_HUMAN
θ value	4.92598e-06 (rank : 49)	NC score	0.546468 (rank : 42)
Query Neighborhood Hits	396	Target Neighborhood Hits	276	Shared Neighborhood Hits	183
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_HUMAN
θ value	6.43352e-06 (rank : 50)	NC score	0.531968 (rank : 50)
Query Neighborhood Hits	396	Target Neighborhood Hits	347	Shared Neighborhood Hits	199
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CRK_HUMAN
θ value	8.40245e-06 (rank : 51)	NC score	0.523576 (rank : 55)
Query Neighborhood Hits	396	Target Neighborhood Hits	308	Shared Neighborhood Hits	192
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCF4_MOUSE
θ value	8.40245e-06 (rank : 52)	NC score	0.607649 (rank : 15)
Query Neighborhood Hits	396	Target Neighborhood Hits	177	Shared Neighborhood Hits	150
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI2_HUMAN
θ value	1.09739e-05 (rank : 53)	NC score	0.605059 (rank : 17)
Query Neighborhood Hits	396	Target Neighborhood Hits	350	Shared Neighborhood Hits	208
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	1.09739e-05 (rank : 54)	NC score	0.607148 (rank : 16)
Query Neighborhood Hits	396	Target Neighborhood Hits	266	Shared Neighborhood Hits	192
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

FNBP2_HUMAN
θ value	1.09739e-05 (rank : 55)	NC score	0.328450 (rank : 107)
Query Neighborhood Hits	396	Target Neighborhood Hits	432	Shared Neighborhood Hits	162
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

STAC_MOUSE
θ value	1.09739e-05 (rank : 56)	NC score	0.533304 (rank : 47)
Query Neighborhood Hits	396	Target Neighborhood Hits	268	Shared Neighborhood Hits	179
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CRKL_HUMAN
θ value	1.43324e-05 (rank : 57)	NC score	0.537640 (rank : 46)
Query Neighborhood Hits	396	Target Neighborhood Hits	313	Shared Neighborhood Hits	192
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

OSTF1_HUMAN
θ value	1.43324e-05 (rank : 58)	NC score	0.476176 (rank : 67)
Query Neighborhood Hits	396	Target Neighborhood Hits	466	Shared Neighborhood Hits	201
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

STAM1_HUMAN
θ value	1.43324e-05 (rank : 59)	NC score	0.543564 (rank : 43)
Query Neighborhood Hits	396	Target Neighborhood Hits	271	Shared Neighborhood Hits	190
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	1.43324e-05 (rank : 60)	NC score	0.526841 (rank : 53)
Query Neighborhood Hits	396	Target Neighborhood Hits	288	Shared Neighborhood Hits	188
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SRGP2_HUMAN
θ value	1.87187e-05 (rank : 61)	NC score	0.343745 (rank : 101)
Query Neighborhood Hits	396	Target Neighborhood Hits	331	Shared Neighborhood Hits	161
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

STS1_HUMAN
θ value	1.87187e-05 (rank : 62)	NC score	0.314909 (rank : 112)
Query Neighborhood Hits	396	Target Neighborhood Hits	106	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SRGP1_HUMAN
θ value	2.44474e-05 (rank : 63)	NC score	0.327533 (rank : 109)
Query Neighborhood Hits	396	Target Neighborhood Hits	390	Shared Neighborhood Hits	154
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_MOUSE
θ value	2.44474e-05 (rank : 64)	NC score	0.345879 (rank : 99)
Query Neighborhood Hits	396	Target Neighborhood Hits	324	Shared Neighborhood Hits	162
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STS1_MOUSE
θ value	2.44474e-05 (rank : 65)	NC score	0.313292 (rank : 113)
Query Neighborhood Hits	396	Target Neighborhood Hits	104	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

CRKL_MOUSE
θ value	3.19293e-05 (rank : 66)	NC score	0.532223 (rank : 49)
Query Neighborhood Hits	396	Target Neighborhood Hits	307	Shared Neighborhood Hits	190
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

RHG04_HUMAN
θ value	3.19293e-05 (rank : 67)	NC score	0.362506 (rank : 94)
Query Neighborhood Hits	396	Target Neighborhood Hits	307	Shared Neighborhood Hits	166
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

STAM2_MOUSE
θ value	3.19293e-05 (rank : 68)	NC score	0.532817 (rank : 48)
Query Neighborhood Hits	396	Target Neighborhood Hits	285	Shared Neighborhood Hits	188
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ABI3_MOUSE
θ value	4.1701e-05 (rank : 69)	NC score	0.542909 (rank : 44)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	153
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

GRAP2_MOUSE
θ value	4.1701e-05 (rank : 70)	NC score	0.552003 (rank : 37)
Query Neighborhood Hits	396	Target Neighborhood Hits	297	Shared Neighborhood Hits	196
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PACN2_HUMAN
θ value	4.1701e-05 (rank : 71)	NC score	0.505180 (rank : 59)
Query Neighborhood Hits	396	Target Neighborhood Hits	339	Shared Neighborhood Hits	195
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ABI3_HUMAN
θ value	5.44631e-05 (rank : 72)	NC score	0.548761 (rank : 38)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	155
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

M3KL4_HUMAN
θ value	5.44631e-05 (rank : 73)	NC score	0.178149 (rank : 184)
Query Neighborhood Hits	396	Target Neighborhood Hits	1087	Shared Neighborhood Hits	191
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

GRAP2_HUMAN
θ value	7.1131e-05 (rank : 74)	NC score	0.542349 (rank : 45)
Query Neighborhood Hits	396	Target Neighborhood Hits	304	Shared Neighborhood Hits	196
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

M3K9_HUMAN
θ value	7.1131e-05 (rank : 75)	NC score	0.160038 (rank : 203)
Query Neighborhood Hits	396	Target Neighborhood Hits	1123	Shared Neighborhood Hits	196
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

OSTF1_MOUSE
θ value	9.29e-05 (rank : 76)	NC score	0.458612 (rank : 74)
Query Neighborhood Hits	396	Target Neighborhood Hits	467	Shared Neighborhood Hits	201
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

HCLS1_MOUSE
θ value	0.000121331 (rank : 77)	NC score	0.582053 (rank : 24)
Query Neighborhood Hits	396	Target Neighborhood Hits	329	Shared Neighborhood Hits	190
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

MYO1E_HUMAN
θ value	0.000121331 (rank : 78)	NC score	0.245528 (rank : 140)
Query Neighborhood Hits	396	Target Neighborhood Hits	293	Shared Neighborhood Hits	196
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

P85B_HUMAN
θ value	0.000158464 (rank : 79)	NC score	0.243150 (rank : 141)
Query Neighborhood Hits	396	Target Neighborhood Hits	543	Shared Neighborhood Hits	109
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

HCLS1_HUMAN
θ value	0.00020696 (rank : 80)	NC score	0.575459 (rank : 29)
Query Neighborhood Hits	396	Target Neighborhood Hits	358	Shared Neighborhood Hits	180
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NGEF_HUMAN
θ value	0.00020696 (rank : 81)	NC score	0.275835 (rank : 123)
Query Neighborhood Hits	396	Target Neighborhood Hits	166	Shared Neighborhood Hits	90
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PACN2_MOUSE
θ value	0.00020696 (rank : 82)	NC score	0.500454 (rank : 62)
Query Neighborhood Hits	396	Target Neighborhood Hits	382	Shared Neighborhood Hits	202
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

STS2_HUMAN
θ value	0.00020696 (rank : 83)	NC score	0.356008 (rank : 98)
Query Neighborhood Hits	396	Target Neighborhood Hits	108	Shared Neighborhood Hits	95
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

NGEF_MOUSE
θ value	0.000270298 (rank : 84)	NC score	0.278456 (rank : 122)
Query Neighborhood Hits	396	Target Neighborhood Hits	228	Shared Neighborhood Hits	107
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SRC8_HUMAN
θ value	0.000270298 (rank : 85)	NC score	0.578584 (rank : 27)
Query Neighborhood Hits	396	Target Neighborhood Hits	269	Shared Neighborhood Hits	187
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	0.000270298 (rank : 86)	NC score	0.578197 (rank : 28)
Query Neighborhood Hits	396	Target Neighborhood Hits	292	Shared Neighborhood Hits	189
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

MYO1F_MOUSE
θ value	0.00035302 (rank : 87)	NC score	0.251787 (rank : 135)
Query Neighborhood Hits	396	Target Neighborhood Hits	262	Shared Neighborhood Hits	193
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

JIP2_HUMAN
θ value	0.000461057 (rank : 88)	NC score	0.239997 (rank : 145)
Query Neighborhood Hits	396	Target Neighborhood Hits	288	Shared Neighborhood Hits	81
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.000461057 (rank : 89)	NC score	0.241616 (rank : 143)
Query Neighborhood Hits	396	Target Neighborhood Hits	144	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MYO1F_HUMAN
θ value	0.000461057 (rank : 90)	NC score	0.253260 (rank : 134)
Query Neighborhood Hits	396	Target Neighborhood Hits	275	Shared Neighborhood Hits	194
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

CSK_HUMAN
θ value	0.000602161 (rank : 91)	NC score	0.140522 (rank : 222)
Query Neighborhood Hits	396	Target Neighborhood Hits	1009	Shared Neighborhood Hits	147
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.000602161 (rank : 92)	NC score	0.140650 (rank : 221)
Query Neighborhood Hits	396	Target Neighborhood Hits	1009	Shared Neighborhood Hits	147
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

M3K11_HUMAN
θ value	0.000602161 (rank : 93)	NC score	0.164167 (rank : 195)
Query Neighborhood Hits	396	Target Neighborhood Hits	1136	Shared Neighborhood Hits	201
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SRC_HUMAN
θ value	0.000602161 (rank : 94)	NC score	0.179744 (rank : 179)
Query Neighborhood Hits	396	Target Neighborhood Hits	1058	Shared Neighborhood Hits	192
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

P85B_MOUSE
θ value	0.000786445 (rank : 95)	NC score	0.236505 (rank : 148)
Query Neighborhood Hits	396	Target Neighborhood Hits	519	Shared Neighborhood Hits	105
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SPTA1_HUMAN
θ value	0.000786445 (rank : 96)	NC score	0.242800 (rank : 142)
Query Neighborhood Hits	396	Target Neighborhood Hits	748	Shared Neighborhood Hits	184
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

MDC1_HUMAN
θ value	0.00102713 (rank : 97)	NC score	0.089043 (rank : 316)
Query Neighborhood Hits	396	Target Neighborhood Hits	1446	Shared Neighborhood Hits	111
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

TXK_MOUSE
θ value	0.00102713 (rank : 98)	NC score	0.135781 (rank : 225)
Query Neighborhood Hits	396	Target Neighborhood Hits	980	Shared Neighborhood Hits	152
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

YES_HUMAN
θ value	0.00102713 (rank : 99)	NC score	0.179605 (rank : 180)
Query Neighborhood Hits	396	Target Neighborhood Hits	1059	Shared Neighborhood Hits	192
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	0.00102713 (rank : 100)	NC score	0.181219 (rank : 177)
Query Neighborhood Hits	396	Target Neighborhood Hits	1052	Shared Neighborhood Hits	192
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

M3K10_HUMAN
θ value	0.00134147 (rank : 101)	NC score	0.145804 (rank : 214)
Query Neighborhood Hits	396	Target Neighborhood Hits	1071	Shared Neighborhood Hits	179
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

NPHP1_MOUSE
θ value	0.00134147 (rank : 102)	NC score	0.455536 (rank : 76)
Query Neighborhood Hits	396	Target Neighborhood Hits	267	Shared Neighborhood Hits	172
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

FYN_MOUSE
θ value	0.00175202 (rank : 103)	NC score	0.184167 (rank : 173)
Query Neighborhood Hits	396	Target Neighborhood Hits	1073	Shared Neighborhood Hits	194
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

NCF1_MOUSE
θ value	0.00175202 (rank : 104)	NC score	0.521918 (rank : 56)
Query Neighborhood Hits	396	Target Neighborhood Hits	198	Shared Neighborhood Hits	167
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

AHI1_MOUSE
θ value	0.00228821 (rank : 105)	NC score	0.386898 (rank : 85)
Query Neighborhood Hits	396	Target Neighborhood Hits	496	Shared Neighborhood Hits	201
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

FYN_HUMAN
θ value	0.00228821 (rank : 106)	NC score	0.180944 (rank : 178)
Query Neighborhood Hits	396	Target Neighborhood Hits	1078	Shared Neighborhood Hits	194
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SPTA1_MOUSE
θ value	0.00228821 (rank : 107)	NC score	0.247190 (rank : 138)
Query Neighborhood Hits	396	Target Neighborhood Hits	675	Shared Neighborhood Hits	174
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CYLC1_HUMAN
θ value	0.00390308 (rank : 108)	NC score	0.082851 (rank : 332)
Query Neighborhood Hits	396	Target Neighborhood Hits	408	Shared Neighborhood Hits	44
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

DDEF2_MOUSE
θ value	0.00390308 (rank : 109)	NC score	0.245952 (rank : 139)
Query Neighborhood Hits	396	Target Neighborhood Hits	625	Shared Neighborhood Hits	177
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

MAP1B_MOUSE
θ value	0.00390308 (rank : 110)	NC score	0.089801 (rank : 311)
Query Neighborhood Hits	396	Target Neighborhood Hits	977	Shared Neighborhood Hits	74
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

PACN3_HUMAN
θ value	0.00390308 (rank : 111)	NC score	0.467050 (rank : 69)
Query Neighborhood Hits	396	Target Neighborhood Hits	385	Shared Neighborhood Hits	184
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

RIMB1_MOUSE
θ value	0.00390308 (rank : 112)	NC score	0.194062 (rank : 172)
Query Neighborhood Hits	396	Target Neighborhood Hits	1376	Shared Neighborhood Hits	200
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

BTK_HUMAN
θ value	0.00509761 (rank : 113)	NC score	0.160203 (rank : 201)
Query Neighborhood Hits	396	Target Neighborhood Hits	1026	Shared Neighborhood Hits	189
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SHLB1_MOUSE
θ value	0.00509761 (rank : 114)	NC score	0.339520 (rank : 104)
Query Neighborhood Hits	396	Target Neighborhood Hits	101	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	0.00509761 (rank : 115)	NC score	0.310128 (rank : 116)
Query Neighborhood Hits	396	Target Neighborhood Hits	86	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	0.00509761 (rank : 116)	NC score	0.312094 (rank : 114)
Query Neighborhood Hits	396	Target Neighborhood Hits	88	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

JIP1_HUMAN
θ value	0.00665767 (rank : 117)	NC score	0.216395 (rank : 154)
Query Neighborhood Hits	396	Target Neighborhood Hits	271	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	0.00665767 (rank : 118)	NC score	0.218731 (rank : 153)
Query Neighborhood Hits	396	Target Neighborhood Hits	259	Shared Neighborhood Hits	78
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

PACN1_HUMAN
θ value	0.00665767 (rank : 119)	NC score	0.490040 (rank : 65)
Query Neighborhood Hits	396	Target Neighborhood Hits	320	Shared Neighborhood Hits	188
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.00665767 (rank : 120)	NC score	0.489146 (rank : 66)
Query Neighborhood Hits	396	Target Neighborhood Hits	283	Shared Neighborhood Hits	185
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PI5PA_HUMAN
θ value	0.00665767 (rank : 121)	NC score	0.052021 (rank : 437)
Query Neighborhood Hits	396	Target Neighborhood Hits	749	Shared Neighborhood Hits	57
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

SNX18_MOUSE
θ value	0.00665767 (rank : 122)	NC score	0.386552 (rank : 86)
Query Neighborhood Hits	396	Target Neighborhood Hits	198	Shared Neighborhood Hits	133
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

MAP1B_HUMAN
θ value	0.00869519 (rank : 123)	NC score	0.094102 (rank : 305)
Query Neighborhood Hits	396	Target Neighborhood Hits	903	Shared Neighborhood Hits	79
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

P85A_MOUSE
θ value	0.00869519 (rank : 124)	NC score	0.264077 (rank : 130)
Query Neighborhood Hits	396	Target Neighborhood Hits	435	Shared Neighborhood Hits	130
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PACN3_MOUSE
θ value	0.00869519 (rank : 125)	NC score	0.464944 (rank : 71)
Query Neighborhood Hits	396	Target Neighborhood Hits	380	Shared Neighborhood Hits	187
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

REN3B_HUMAN
θ value	0.00869519 (rank : 126)	NC score	0.079005 (rank : 345)
Query Neighborhood Hits	396	Target Neighborhood Hits	412	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

AHI1_HUMAN
θ value	0.0113563 (rank : 127)	NC score	0.382511 (rank : 88)
Query Neighborhood Hits	396	Target Neighborhood Hits	537	Shared Neighborhood Hits	197
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG5_HUMAN
θ value	0.0113563 (rank : 128)	NC score	0.295073 (rank : 117)
Query Neighborhood Hits	396	Target Neighborhood Hits	172	Shared Neighborhood Hits	105
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NCF1_HUMAN
θ value	0.0113563 (rank : 129)	NC score	0.512961 (rank : 58)
Query Neighborhood Hits	396	Target Neighborhood Hits	198	Shared Neighborhood Hits	156
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PLCG1_MOUSE
θ value	0.0113563 (rank : 130)	NC score	0.381835 (rank : 89)
Query Neighborhood Hits	396	Target Neighborhood Hits	314	Shared Neighborhood Hits	166
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SHLB1_HUMAN
θ value	0.0113563 (rank : 131)	NC score	0.331809 (rank : 106)
Query Neighborhood Hits	396	Target Neighborhood Hits	96	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

BCAR1_HUMAN
θ value	0.0148317 (rank : 132)	NC score	0.360721 (rank : 97)
Query Neighborhood Hits	396	Target Neighborhood Hits	554	Shared Neighborhood Hits	176
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DDEF1_MOUSE
θ value	0.0148317 (rank : 133)	NC score	0.257600 (rank : 133)
Query Neighborhood Hits	396	Target Neighborhood Hits	592	Shared Neighborhood Hits	166
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DOCK1_HUMAN
θ value	0.0148317 (rank : 134)	NC score	0.214738 (rank : 157)
Query Neighborhood Hits	396	Target Neighborhood Hits	191	Shared Neighborhood Hits	124
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

FGR_HUMAN
θ value	0.0148317 (rank : 135)	NC score	0.181514 (rank : 176)
Query Neighborhood Hits	396	Target Neighborhood Hits	1067	Shared Neighborhood Hits	191
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

BIN1_MOUSE
θ value	0.0193708 (rank : 136)	NC score	0.219542 (rank : 152)
Query Neighborhood Hits	396	Target Neighborhood Hits	283	Shared Neighborhood Hits	107
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BTK_MOUSE
θ value	0.0252991 (rank : 137)	NC score	0.153969 (rank : 210)
Query Neighborhood Hits	396	Target Neighborhood Hits	1017	Shared Neighborhood Hits	178
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

P85A_HUMAN
θ value	0.0252991 (rank : 138)	NC score	0.250003 (rank : 136)
Query Neighborhood Hits	396	Target Neighborhood Hits	479	Shared Neighborhood Hits	127
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNX18_HUMAN
θ value	0.0252991 (rank : 139)	NC score	0.377323 (rank : 91)
Query Neighborhood Hits	396	Target Neighborhood Hits	207	Shared Neighborhood Hits	138
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

EFS_HUMAN
θ value	0.0330416 (rank : 140)	NC score	0.381402 (rank : 90)
Query Neighborhood Hits	396	Target Neighborhood Hits	348	Shared Neighborhood Hits	160
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

MX1_MOUSE
θ value	0.0330416 (rank : 141)	NC score	0.038019 (rank : 491)
Query Neighborhood Hits	396	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P09922	Gene names	Mx1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein).

NPHP1_HUMAN
θ value	0.0330416 (rank : 142)	NC score	0.406899 (rank : 83)
Query Neighborhood Hits	396	Target Neighborhood Hits	288	Shared Neighborhood Hits	169
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

BIN1_HUMAN
θ value	0.0431538 (rank : 143)	NC score	0.216314 (rank : 155)
Query Neighborhood Hits	396	Target Neighborhood Hits	335	Shared Neighborhood Hits	104
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

TXK_HUMAN
θ value	0.0431538 (rank : 144)	NC score	0.125741 (rank : 234)
Query Neighborhood Hits	396	Target Neighborhood Hits	971	Shared Neighborhood Hits	137
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ATX2_HUMAN
θ value	0.0563607 (rank : 145)	NC score	0.048114 (rank : 467)
Query Neighborhood Hits	396	Target Neighborhood Hits	375	Shared Neighborhood Hits	36
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

PLCG1_HUMAN
θ value	0.0563607 (rank : 146)	NC score	0.362105 (rank : 95)
Query Neighborhood Hits	396	Target Neighborhood Hits	293	Shared Neighborhood Hits	158
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RIMB2_MOUSE
θ value	0.0563607 (rank : 147)	NC score	0.328376 (rank : 108)
Query Neighborhood Hits	396	Target Neighborhood Hits	246	Shared Neighborhood Hits	116
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

BCAR1_MOUSE
θ value	0.0736092 (rank : 148)	NC score	0.368247 (rank : 92)
Query Neighborhood Hits	396	Target Neighborhood Hits	438	Shared Neighborhood Hits	176
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DBNL_HUMAN
θ value	0.0736092 (rank : 149)	NC score	0.464482 (rank : 72)
Query Neighborhood Hits	396	Target Neighborhood Hits	244	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.0736092 (rank : 150)	NC score	0.456678 (rank : 75)
Query Neighborhood Hits	396	Target Neighborhood Hits	306	Shared Neighborhood Hits	159
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EFS_MOUSE
θ value	0.0736092 (rank : 151)	NC score	0.387267 (rank : 84)
Query Neighborhood Hits	396	Target Neighborhood Hits	389	Shared Neighborhood Hits	167
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FGR_MOUSE
θ value	0.0736092 (rank : 152)	NC score	0.173689 (rank : 188)
Query Neighborhood Hits	396	Target Neighborhood Hits	1069	Shared Neighborhood Hits	191
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MAGC1_HUMAN
θ value	0.0736092 (rank : 153)	NC score	0.027854 (rank : 517)
Query Neighborhood Hits	396	Target Neighborhood Hits	431	Shared Neighborhood Hits	46
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

RHG26_HUMAN
θ value	0.0736092 (rank : 154)	NC score	0.285414 (rank : 120)
Query Neighborhood Hits	396	Target Neighborhood Hits	281	Shared Neighborhood Hits	148
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

TACC2_HUMAN
θ value	0.0736092 (rank : 155)	NC score	0.057649 (rank : 401)
Query Neighborhood Hits	396	Target Neighborhood Hits	856	Shared Neighborhood Hits	79
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

AMPH_MOUSE
θ value	0.0961366 (rank : 156)	NC score	0.203434 (rank : 162)
Query Neighborhood Hits	396	Target Neighborhood Hits	291	Shared Neighborhood Hits	100
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BAIP2_HUMAN
θ value	0.0961366 (rank : 157)	NC score	0.178405 (rank : 183)
Query Neighborhood Hits	396	Target Neighborhood Hits	192	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	0.0961366 (rank : 158)	NC score	0.179380 (rank : 181)
Query Neighborhood Hits	396	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

CASL_MOUSE
θ value	0.0961366 (rank : 159)	NC score	0.340376 (rank : 103)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	150
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

FUT8_HUMAN
θ value	0.0961366 (rank : 160)	NC score	0.150690 (rank : 212)
Query Neighborhood Hits	396	Target Neighborhood Hits	67	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

TP53B_MOUSE
θ value	0.0961366 (rank : 161)	NC score	0.054884 (rank : 411)
Query Neighborhood Hits	396	Target Neighborhood Hits	644	Shared Neighborhood Hits	55
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ARHG4_HUMAN
θ value	0.125558 (rank : 162)	NC score	0.365213 (rank : 93)
Query Neighborhood Hits	396	Target Neighborhood Hits	242	Shared Neighborhood Hits	161
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CASL_HUMAN
θ value	0.125558 (rank : 163)	NC score	0.336062 (rank : 105)
Query Neighborhood Hits	396	Target Neighborhood Hits	259	Shared Neighborhood Hits	152
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DOCK4_HUMAN
θ value	0.125558 (rank : 164)	NC score	0.087384 (rank : 319)
Query Neighborhood Hits	396	Target Neighborhood Hits	237	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	0.125558 (rank : 165)	NC score	0.088269 (rank : 317)
Query Neighborhood Hits	396	Target Neighborhood Hits	210	Shared Neighborhood Hits	41
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

EPS8_HUMAN
θ value	0.125558 (rank : 166)	NC score	0.215443 (rank : 156)
Query Neighborhood Hits	396	Target Neighborhood Hits	151	Shared Neighborhood Hits	108
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

NKTR_HUMAN
θ value	0.125558 (rank : 167)	NC score	0.028691 (rank : 515)
Query Neighborhood Hits	396	Target Neighborhood Hits	658	Shared Neighborhood Hits	44
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

K0240_MOUSE
θ value	0.163984 (rank : 168)	NC score	0.049657 (rank : 462)
Query Neighborhood Hits	396	Target Neighborhood Hits	211	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CHH5	Gene names	Kiaa0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

PLCG2_HUMAN
θ value	0.163984 (rank : 169)	NC score	0.361429 (rank : 96)
Query Neighborhood Hits	396	Target Neighborhood Hits	280	Shared Neighborhood Hits	156
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SNX9_HUMAN
θ value	0.163984 (rank : 170)	NC score	0.273166 (rank : 126)
Query Neighborhood Hits	396	Target Neighborhood Hits	148	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SRC_MOUSE
θ value	0.163984 (rank : 171)	NC score	0.155479 (rank : 208)
Query Neighborhood Hits	396	Target Neighborhood Hits	1033	Shared Neighborhood Hits	171
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

THAP4_MOUSE
θ value	0.163984 (rank : 172)	NC score	0.037399 (rank : 494)
Query Neighborhood Hits	396	Target Neighborhood Hits	130	Shared Neighborhood Hits	15
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

ASPP1_MOUSE
θ value	0.21417 (rank : 173)	NC score	0.239119 (rank : 146)
Query Neighborhood Hits	396	Target Neighborhood Hits	1244	Shared Neighborhood Hits	204
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	0.21417 (rank : 174)	NC score	0.203485 (rank : 161)
Query Neighborhood Hits	396	Target Neighborhood Hits	1156	Shared Neighborhood Hits	185
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

DDEF2_HUMAN
θ value	0.21417 (rank : 175)	NC score	0.235263 (rank : 149)
Query Neighborhood Hits	396	Target Neighborhood Hits	599	Shared Neighborhood Hits	173
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

HCK_MOUSE
θ value	0.21417 (rank : 176)	NC score	0.154561 (rank : 209)
Query Neighborhood Hits	396	Target Neighborhood Hits	1029	Shared Neighborhood Hits	181
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

RIMB1_HUMAN
θ value	0.21417 (rank : 177)	NC score	0.201080 (rank : 166)
Query Neighborhood Hits	396	Target Neighborhood Hits	1479	Shared Neighborhood Hits	196
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SNX9_MOUSE
θ value	0.21417 (rank : 178)	NC score	0.247484 (rank : 137)
Query Neighborhood Hits	396	Target Neighborhood Hits	141	Shared Neighborhood Hits	93
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

BLK_HUMAN
θ value	0.279714 (rank : 179)	NC score	0.136235 (rank : 223)
Query Neighborhood Hits	396	Target Neighborhood Hits	994	Shared Neighborhood Hits	151
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DIDO1_HUMAN
θ value	0.279714 (rank : 180)	NC score	0.038917 (rank : 487)
Query Neighborhood Hits	396	Target Neighborhood Hits	960	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

ES8L3_HUMAN
θ value	0.279714 (rank : 181)	NC score	0.267119 (rank : 128)
Query Neighborhood Hits	396	Target Neighborhood Hits	206	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FUT8_MOUSE
θ value	0.279714 (rank : 182)	NC score	0.143523 (rank : 216)
Query Neighborhood Hits	396	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

LYN_MOUSE
θ value	0.279714 (rank : 183)	NC score	0.141830 (rank : 219)
Query Neighborhood Hits	396	Target Neighborhood Hits	1023	Shared Neighborhood Hits	167
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NFH_MOUSE
θ value	0.279714 (rank : 184)	NC score	0.044336 (rank : 471)
Query Neighborhood Hits	396	Target Neighborhood Hits	2247	Shared Neighborhood Hits	141
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RBBP6_MOUSE
θ value	0.279714 (rank : 185)	NC score	0.071395 (rank : 370)
Query Neighborhood Hits	396	Target Neighborhood Hits	1014	Shared Neighborhood Hits	67
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

BLK_MOUSE
θ value	0.365318 (rank : 186)	NC score	0.133946 (rank : 226)
Query Neighborhood Hits	396	Target Neighborhood Hits	992	Shared Neighborhood Hits	140
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FRK_HUMAN
θ value	0.365318 (rank : 187)	NC score	0.143484 (rank : 217)
Query Neighborhood Hits	396	Target Neighborhood Hits	1058	Shared Neighborhood Hits	184
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

KCTD8_HUMAN
θ value	0.365318 (rank : 188)	NC score	0.017950 (rank : 550)
Query Neighborhood Hits	396	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZWB6	Gene names	KCTD8
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD8.

RHG09_HUMAN
θ value	0.365318 (rank : 189)	NC score	0.114979 (rank : 259)
Query Neighborhood Hits	396	Target Neighborhood Hits	186	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

SCG2_HUMAN
θ value	0.365318 (rank : 190)	NC score	0.035390 (rank : 502)
Query Neighborhood Hits	396	Target Neighborhood Hits	190	Shared Neighborhood Hits	19
SwissProt Accessions	P13521, Q8TBH3	Gene names	SCG2, CHGC
Domain Architecture
Description	Secretogranin-2 precursor (Secretogranin II) (SgII) (Chromogranin C) [Contains: Secretoneurin (SN)].

SRRM2_HUMAN
θ value	0.365318 (rank : 191)	NC score	0.073585 (rank : 358)
Query Neighborhood Hits	396	Target Neighborhood Hits	1296	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TRIO_HUMAN
θ value	0.365318 (rank : 192)	NC score	0.078711 (rank : 346)
Query Neighborhood Hits	396	Target Neighborhood Hits	1580	Shared Neighborhood Hits	131
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ANM2_HUMAN
θ value	0.47712 (rank : 193)	NC score	0.274552 (rank : 124)
Query Neighborhood Hits	396	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHGG_HUMAN
θ value	0.47712 (rank : 194)	NC score	0.206125 (rank : 160)
Query Neighborhood Hits	396	Target Neighborhood Hits	129	Shared Neighborhood Hits	59
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DOCK3_HUMAN
θ value	0.47712 (rank : 195)	NC score	0.080792 (rank : 337)
Query Neighborhood Hits	396	Target Neighborhood Hits	87	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	0.47712 (rank : 196)	NC score	0.084044 (rank : 326)
Query Neighborhood Hits	396	Target Neighborhood Hits	93	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

K1802_MOUSE
θ value	0.47712 (rank : 197)	NC score	0.035044 (rank : 503)
Query Neighborhood Hits	396	Target Neighborhood Hits	1596	Shared Neighborhood Hits	101
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LYN_HUMAN
θ value	0.47712 (rank : 198)	NC score	0.141754 (rank : 220)
Query Neighborhood Hits	396	Target Neighborhood Hits	1022	Shared Neighborhood Hits	168
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PDE1A_HUMAN
θ value	0.47712 (rank : 199)	NC score	0.015313 (rank : 560)
Query Neighborhood Hits	396	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

RBBP6_HUMAN
θ value	0.47712 (rank : 200)	NC score	0.062449 (rank : 392)
Query Neighborhood Hits	396	Target Neighborhood Hits	1135	Shared Neighborhood Hits	78
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RPB1_HUMAN
θ value	0.47712 (rank : 201)	NC score	0.054430 (rank : 416)
Query Neighborhood Hits	396	Target Neighborhood Hits	362	Shared Neighborhood Hits	48
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	0.47712 (rank : 202)	NC score	0.052888 (rank : 429)
Query Neighborhood Hits	396	Target Neighborhood Hits	363	Shared Neighborhood Hits	46
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SRMS_HUMAN
θ value	0.47712 (rank : 203)	NC score	0.096021 (rank : 303)
Query Neighborhood Hits	396	Target Neighborhood Hits	946	Shared Neighborhood Hits	91
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

TCAL3_HUMAN
θ value	0.47712 (rank : 204)	NC score	0.035671 (rank : 500)
Query Neighborhood Hits	396	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q969E4	Gene names	TCEAL3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

ZFHX2_HUMAN
θ value	0.47712 (rank : 205)	NC score	0.011437 (rank : 572)
Query Neighborhood Hits	396	Target Neighborhood Hits	1178	Shared Neighborhood Hits	32
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

AAT1_MOUSE
θ value	0.62314 (rank : 206)	NC score	0.037036 (rank : 498)
Query Neighborhood Hits	396	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BRC6	Gene names	Aat1
Domain Architecture	No domain graphic available
Description	AMY-1-associating protein expressed in testis 1 homolog (AAT-1).

ARHG9_HUMAN
θ value	0.62314 (rank : 207)	NC score	0.343783 (rank : 100)
Query Neighborhood Hits	396	Target Neighborhood Hits	235	Shared Neighborhood Hits	155
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.62314 (rank : 208)	NC score	0.343431 (rank : 102)
Query Neighborhood Hits	396	Target Neighborhood Hits	234	Shared Neighborhood Hits	154
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGG_MOUSE
θ value	0.62314 (rank : 209)	NC score	0.228025 (rank : 150)
Query Neighborhood Hits	396	Target Neighborhood Hits	152	Shared Neighborhood Hits	74
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	0.62314 (rank : 210)	NC score	0.238090 (rank : 147)
Query Neighborhood Hits	396	Target Neighborhood Hits	956	Shared Neighborhood Hits	191
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAT3_HUMAN
θ value	0.62314 (rank : 211)	NC score	0.039805 (rank : 484)
Query Neighborhood Hits	396	Target Neighborhood Hits	490	Shared Neighborhood Hits	43
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

CT032_HUMAN
θ value	0.62314 (rank : 212)	NC score	0.385032 (rank : 87)
Query Neighborhood Hits	396	Target Neighborhood Hits	235	Shared Neighborhood Hits	142
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

HCK_HUMAN
θ value	0.62314 (rank : 213)	NC score	0.152669 (rank : 211)
Query Neighborhood Hits	396	Target Neighborhood Hits	1035	Shared Neighborhood Hits	180
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

K2027_HUMAN
θ value	0.62314 (rank : 214)	NC score	0.037554 (rank : 493)
Query Neighborhood Hits	396	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

LCK_MOUSE
θ value	0.62314 (rank : 215)	NC score	0.123589 (rank : 239)
Query Neighborhood Hits	396	Target Neighborhood Hits	981	Shared Neighborhood Hits	128
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

NIPBL_HUMAN
θ value	0.62314 (rank : 216)	NC score	0.049218 (rank : 463)
Query Neighborhood Hits	396	Target Neighborhood Hits	1311	Shared Neighborhood Hits	86
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PKHA6_HUMAN
θ value	0.62314 (rank : 217)	NC score	0.022367 (rank : 532)
Query Neighborhood Hits	396	Target Neighborhood Hits	556	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SRMS_MOUSE
θ value	0.62314 (rank : 218)	NC score	0.103016 (rank : 291)
Query Neighborhood Hits	396	Target Neighborhood Hits	964	Shared Neighborhood Hits	113
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TBX2_HUMAN
θ value	0.62314 (rank : 219)	NC score	0.015958 (rank : 557)
Query Neighborhood Hits	396	Target Neighborhood Hits	195	Shared Neighborhood Hits	18
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

TCAL5_HUMAN
θ value	0.62314 (rank : 220)	NC score	0.037372 (rank : 495)
Query Neighborhood Hits	396	Target Neighborhood Hits	806	Shared Neighborhood Hits	55
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TOP1_HUMAN
θ value	0.62314 (rank : 221)	NC score	0.031995 (rank : 509)
Query Neighborhood Hits	396	Target Neighborhood Hits	207	Shared Neighborhood Hits	25
SwissProt Accessions	P11387, O43256, Q12855, Q12856, Q15610, Q5TFY3, Q9UJN0	Gene names	TOP1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

TRIPB_HUMAN
θ value	0.62314 (rank : 222)	NC score	0.039067 (rank : 486)
Query Neighborhood Hits	396	Target Neighborhood Hits	1587	Shared Neighborhood Hits	87
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

UBP29_MOUSE
θ value	0.62314 (rank : 223)	NC score	0.017835 (rank : 551)
Query Neighborhood Hits	396	Target Neighborhood Hits	95	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ES63	Gene names	Usp29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

ZAN_HUMAN
θ value	0.62314 (rank : 224)	NC score	0.024750 (rank : 528)
Query Neighborhood Hits	396	Target Neighborhood Hits	679	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ZN174_HUMAN
θ value	0.62314 (rank : 225)	NC score	-0.007291 (rank : 599)
Query Neighborhood Hits	396	Target Neighborhood Hits	744	Shared Neighborhood Hits	11
SwissProt Accessions	Q15697, Q9BQ34	Gene names	ZNF174, ZSCAN8
Domain Architecture
Description	Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8).

AFF4_HUMAN
θ value	0.813845 (rank : 226)	NC score	0.049686 (rank : 461)
Query Neighborhood Hits	396	Target Neighborhood Hits	611	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

GMIP_MOUSE
θ value	0.813845 (rank : 227)	NC score	0.073476 (rank : 359)
Query Neighborhood Hits	396	Target Neighborhood Hits	202	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

IASPP_MOUSE
θ value	0.813845 (rank : 228)	NC score	0.241487 (rank : 144)
Query Neighborhood Hits	396	Target Neighborhood Hits	1024	Shared Neighborhood Hits	198
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PDE1A_MOUSE
θ value	0.813845 (rank : 229)	NC score	0.014461 (rank : 562)
Query Neighborhood Hits	396	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

RFIP1_HUMAN
θ value	0.813845 (rank : 230)	NC score	0.053416 (rank : 423)
Query Neighborhood Hits	396	Target Neighborhood Hits	236	Shared Neighborhood Hits	31
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

SRRM2_MOUSE
θ value	0.813845 (rank : 231)	NC score	0.072070 (rank : 365)
Query Neighborhood Hits	396	Target Neighborhood Hits	1470	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

STAC3_MOUSE
θ value	0.813845 (rank : 232)	NC score	0.429531 (rank : 81)
Query Neighborhood Hits	396	Target Neighborhood Hits	232	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ANM2_MOUSE
θ value	1.06291 (rank : 233)	NC score	0.260755 (rank : 131)
Query Neighborhood Hits	396	Target Neighborhood Hits	175	Shared Neighborhood Hits	141
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ELK4_HUMAN
θ value	1.06291 (rank : 234)	NC score	0.017351 (rank : 554)
Query Neighborhood Hits	396	Target Neighborhood Hits	184	Shared Neighborhood Hits	19
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

EM55_HUMAN
θ value	1.06291 (rank : 235)	NC score	0.125211 (rank : 235)
Query Neighborhood Hits	396	Target Neighborhood Hits	228	Shared Neighborhood Hits	97
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

ES8L3_MOUSE
θ value	1.06291 (rank : 236)	NC score	0.282911 (rank : 121)
Query Neighborhood Hits	396	Target Neighborhood Hits	168	Shared Neighborhood Hits	141
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

JUN_MOUSE
θ value	1.06291 (rank : 237)	NC score	0.019610 (rank : 539)
Query Neighborhood Hits	396	Target Neighborhood Hits	145	Shared Neighborhood Hits	7
SwissProt Accessions	P05627	Gene names	Jun
Domain Architecture
Description	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A) (AH119).

LCK_HUMAN
θ value	1.06291 (rank : 238)	NC score	0.124576 (rank : 237)
Query Neighborhood Hits	396	Target Neighborhood Hits	987	Shared Neighborhood Hits	129
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

MLL2_HUMAN
θ value	1.06291 (rank : 239)	NC score	0.053021 (rank : 426)
Query Neighborhood Hits	396	Target Neighborhood Hits	1788	Shared Neighborhood Hits	117
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MPP8_HUMAN
θ value	1.06291 (rank : 240)	NC score	0.034503 (rank : 505)
Query Neighborhood Hits	396	Target Neighborhood Hits	948	Shared Neighborhood Hits	74
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

PP4R1_MOUSE
θ value	1.06291 (rank : 241)	NC score	0.027927 (rank : 516)
Query Neighborhood Hits	396	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

PYR1_HUMAN
θ value	1.06291 (rank : 242)	NC score	0.018415 (rank : 548)
Query Neighborhood Hits	396	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

BI2L1_MOUSE
θ value	1.38821 (rank : 243)	NC score	0.164687 (rank : 194)
Query Neighborhood Hits	396	Target Neighborhood Hits	197	Shared Neighborhood Hits	74
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CD248_MOUSE
θ value	1.38821 (rank : 244)	NC score	0.010711 (rank : 576)
Query Neighborhood Hits	396	Target Neighborhood Hits	578	Shared Neighborhood Hits	28
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CEL_HUMAN
θ value	1.38821 (rank : 245)	NC score	0.020782 (rank : 535)
Query Neighborhood Hits	396	Target Neighborhood Hits	896	Shared Neighborhood Hits	62
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

EPS8_MOUSE
θ value	1.38821 (rank : 246)	NC score	0.209829 (rank : 159)
Query Neighborhood Hits	396	Target Neighborhood Hits	157	Shared Neighborhood Hits	120
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

HXB3_HUMAN
θ value	1.38821 (rank : 247)	NC score	0.003327 (rank : 591)
Query Neighborhood Hits	396	Target Neighborhood Hits	559	Shared Neighborhood Hits	24
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

IASPP_HUMAN
θ value	1.38821 (rank : 248)	NC score	0.260480 (rank : 132)
Query Neighborhood Hits	396	Target Neighborhood Hits	688	Shared Neighborhood Hits	178
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MATK_MOUSE
θ value	1.38821 (rank : 249)	NC score	0.098229 (rank : 299)
Query Neighborhood Hits	396	Target Neighborhood Hits	952	Shared Neighborhood Hits	95
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MILK1_HUMAN
θ value	1.38821 (rank : 250)	NC score	0.040903 (rank : 480)
Query Neighborhood Hits	396	Target Neighborhood Hits	427	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

PCLO_HUMAN
θ value	1.38821 (rank : 251)	NC score	0.064999 (rank : 385)
Query Neighborhood Hits	396	Target Neighborhood Hits	2046	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RPGR_HUMAN
θ value	1.38821 (rank : 252)	NC score	0.024298 (rank : 529)
Query Neighborhood Hits	396	Target Neighborhood Hits	279	Shared Neighborhood Hits	22
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RUSC1_HUMAN
θ value	1.38821 (rank : 253)	NC score	0.293665 (rank : 118)
Query Neighborhood Hits	396	Target Neighborhood Hits	226	Shared Neighborhood Hits	139
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SLY_HUMAN
θ value	1.38821 (rank : 254)	NC score	0.163843 (rank : 196)
Query Neighborhood Hits	396	Target Neighborhood Hits	81	Shared Neighborhood Hits	56
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

STAC3_HUMAN
θ value	1.38821 (rank : 255)	NC score	0.426201 (rank : 82)
Query Neighborhood Hits	396	Target Neighborhood Hits	228	Shared Neighborhood Hits	147
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TCGAP_HUMAN
θ value	1.38821 (rank : 256)	NC score	0.201679 (rank : 164)
Query Neighborhood Hits	396	Target Neighborhood Hits	872	Shared Neighborhood Hits	163
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	1.38821 (rank : 257)	NC score	0.222496 (rank : 151)
Query Neighborhood Hits	396	Target Neighborhood Hits	409	Shared Neighborhood Hits	148
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TOPRS_MOUSE
θ value	1.38821 (rank : 258)	NC score	0.018441 (rank : 547)
Query Neighborhood Hits	396	Target Neighborhood Hits	263	Shared Neighborhood Hits	11
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

ANKR6_HUMAN
θ value	1.81305 (rank : 259)	NC score	0.016672 (rank : 555)
Query Neighborhood Hits	396	Target Neighborhood Hits	439	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

EM55_MOUSE
θ value	1.81305 (rank : 260)	NC score	0.119464 (rank : 246)
Query Neighborhood Hits	396	Target Neighborhood Hits	221	Shared Neighborhood Hits	93
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

K0240_HUMAN
θ value	1.81305 (rank : 261)	NC score	0.036797 (rank : 499)
Query Neighborhood Hits	396	Target Neighborhood Hits	96	Shared Neighborhood Hits	7
SwissProt Accessions	Q6AI39, Q5TFZ3, Q92514	Gene names	KIAA0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

MAP9_HUMAN
θ value	1.81305 (rank : 262)	NC score	0.042472 (rank : 477)
Query Neighborhood Hits	396	Target Neighborhood Hits	518	Shared Neighborhood Hits	48
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

MYH10_HUMAN
θ value	1.81305 (rank : 263)	NC score	0.040324 (rank : 483)
Query Neighborhood Hits	396	Target Neighborhood Hits	1620	Shared Neighborhood Hits	88
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	1.81305 (rank : 264)	NC score	0.041299 (rank : 478)
Query Neighborhood Hits	396	Target Neighborhood Hits	1612	Shared Neighborhood Hits	90
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NACAM_MOUSE
θ value	1.81305 (rank : 265)	NC score	0.065220 (rank : 384)
Query Neighborhood Hits	396	Target Neighborhood Hits	1866	Shared Neighborhood Hits	139
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCOR2_HUMAN
θ value	1.81305 (rank : 266)	NC score	0.043372 (rank : 475)
Query Neighborhood Hits	396	Target Neighborhood Hits	870	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NFH_HUMAN
θ value	1.81305 (rank : 267)	NC score	0.032376 (rank : 508)
Query Neighborhood Hits	396	Target Neighborhood Hits	1242	Shared Neighborhood Hits	94
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RHG12_MOUSE
θ value	1.81305 (rank : 268)	NC score	0.105602 (rank : 284)
Query Neighborhood Hits	396	Target Neighborhood Hits	204	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RIMB2_HUMAN
θ value	1.81305 (rank : 269)	NC score	0.317486 (rank : 110)
Query Neighborhood Hits	396	Target Neighborhood Hits	263	Shared Neighborhood Hits	128
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

S3TC2_HUMAN
θ value	1.81305 (rank : 270)	NC score	0.067965 (rank : 380)
Query Neighborhood Hits	396	Target Neighborhood Hits	70	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

SHAN1_HUMAN
θ value	1.81305 (rank : 271)	NC score	0.162200 (rank : 200)
Query Neighborhood Hits	396	Target Neighborhood Hits	1041	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

AMPH_HUMAN
θ value	2.36792 (rank : 272)	NC score	0.212510 (rank : 158)
Query Neighborhood Hits	396	Target Neighborhood Hits	455	Shared Neighborhood Hits	113
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

CD008_HUMAN
θ value	2.36792 (rank : 273)	NC score	0.038399 (rank : 489)
Query Neighborhood Hits	396	Target Neighborhood Hits	330	Shared Neighborhood Hits	31
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

DEN1A_HUMAN
θ value	2.36792 (rank : 274)	NC score	0.017773 (rank : 552)
Query Neighborhood Hits	396	Target Neighborhood Hits	176	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DPOLZ_HUMAN
θ value	2.36792 (rank : 275)	NC score	0.019428 (rank : 542)
Query Neighborhood Hits	396	Target Neighborhood Hits	200	Shared Neighborhood Hits	19
SwissProt Accessions	O60673, O43214	Gene names	REV3L, POLZ, REV3
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (hREV3).

ETV3_HUMAN
θ value	2.36792 (rank : 276)	NC score	0.017593 (rank : 553)
Query Neighborhood Hits	396	Target Neighborhood Hits	312	Shared Neighborhood Hits	32
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

FA21C_HUMAN
θ value	2.36792 (rank : 277)	NC score	0.037269 (rank : 496)
Query Neighborhood Hits	396	Target Neighborhood Hits	194	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

HOMEZ_HUMAN
θ value	2.36792 (rank : 278)	NC score	0.018486 (rank : 545)
Query Neighborhood Hits	396	Target Neighborhood Hits	110	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IX15, Q6P049, Q86XB6, Q9P2A5	Gene names	HOMEZ, KIAA1443
Domain Architecture
Description	Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper- containing factor).

MPP10_MOUSE
θ value	2.36792 (rank : 279)	NC score	0.026291 (rank : 524)
Query Neighborhood Hits	396	Target Neighborhood Hits	251	Shared Neighborhood Hits	22
SwissProt Accessions	Q810V0	Gene names	Mphosph10
Domain Architecture	No domain graphic available
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

MY18A_MOUSE
θ value	2.36792 (rank : 280)	NC score	0.046225 (rank : 469)
Query Neighborhood Hits	396	Target Neighborhood Hits	1989	Shared Neighborhood Hits	105
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PVRL1_HUMAN
θ value	2.36792 (rank : 281)	NC score	0.007867 (rank : 585)
Query Neighborhood Hits	396	Target Neighborhood Hits	219	Shared Neighborhood Hits	4
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

SAMN1_HUMAN
θ value	2.36792 (rank : 282)	NC score	0.108713 (rank : 276)
Query Neighborhood Hits	396	Target Neighborhood Hits	74	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SLY_MOUSE
θ value	2.36792 (rank : 283)	NC score	0.183152 (rank : 175)
Query Neighborhood Hits	396	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

WHRN_HUMAN
θ value	2.36792 (rank : 284)	NC score	0.009885 (rank : 578)
Query Neighborhood Hits	396	Target Neighborhood Hits	325	Shared Neighborhood Hits	23
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

ACINU_HUMAN
θ value	3.0926 (rank : 285)	NC score	0.048783 (rank : 466)
Query Neighborhood Hits	396	Target Neighborhood Hits	828	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

AFF4_MOUSE
θ value	3.0926 (rank : 286)	NC score	0.048816 (rank : 464)
Query Neighborhood Hits	396	Target Neighborhood Hits	581	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

BOC_HUMAN
θ value	3.0926 (rank : 287)	NC score	0.000830 (rank : 595)
Query Neighborhood Hits	396	Target Neighborhood Hits	543	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CHD1_HUMAN
θ value	3.0926 (rank : 288)	NC score	0.012119 (rank : 568)
Query Neighborhood Hits	396	Target Neighborhood Hits	337	Shared Neighborhood Hits	22
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CONA1_HUMAN
θ value	3.0926 (rank : 289)	NC score	0.006587 (rank : 588)
Query Neighborhood Hits	396	Target Neighborhood Hits	281	Shared Neighborhood Hits	20
SwissProt Accessions	Q86Y22, Q8IVR4, Q9NT93	Gene names	COL23A1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

CONA1_MOUSE
θ value	3.0926 (rank : 290)	NC score	0.007092 (rank : 587)
Query Neighborhood Hits	396	Target Neighborhood Hits	254	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

CROCC_MOUSE
θ value	3.0926 (rank : 291)	NC score	0.027480 (rank : 520)
Query Neighborhood Hits	396	Target Neighborhood Hits	1460	Shared Neighborhood Hits	77
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

DOCK2_HUMAN
θ value	3.0926 (rank : 292)	NC score	0.098925 (rank : 298)
Query Neighborhood Hits	396	Target Neighborhood Hits	90	Shared Neighborhood Hits	48
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

IF4B_MOUSE
θ value	3.0926 (rank : 293)	NC score	0.027060 (rank : 522)
Query Neighborhood Hits	396	Target Neighborhood Hits	368	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

MAP1A_HUMAN
θ value	3.0926 (rank : 294)	NC score	0.072458 (rank : 364)
Query Neighborhood Hits	396	Target Neighborhood Hits	1626	Shared Neighborhood Hits	112
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MARK2_HUMAN
θ value	3.0926 (rank : 295)	NC score	0.027287 (rank : 521)
Query Neighborhood Hits	396	Target Neighborhood Hits	1056	Shared Neighborhood Hits	67
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

RPGR1_MOUSE
θ value	3.0926 (rank : 296)	NC score	0.037999 (rank : 492)
Query Neighborhood Hits	396	Target Neighborhood Hits	713	Shared Neighborhood Hits	52
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RSF1_HUMAN
θ value	3.0926 (rank : 297)	NC score	0.037247 (rank : 497)
Query Neighborhood Hits	396	Target Neighborhood Hits	539	Shared Neighborhood Hits	47
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

SHAN2_MOUSE
θ value	3.0926 (rank : 298)	NC score	0.201640 (rank : 165)
Query Neighborhood Hits	396	Target Neighborhood Hits	446	Shared Neighborhood Hits	126
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SORC1_HUMAN
θ value	3.0926 (rank : 299)	NC score	0.008501 (rank : 584)
Query Neighborhood Hits	396	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SOX30_MOUSE
θ value	3.0926 (rank : 300)	NC score	0.013722 (rank : 565)
Query Neighborhood Hits	396	Target Neighborhood Hits	374	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

BCOR_HUMAN
θ value	4.03905 (rank : 301)	NC score	0.021413 (rank : 534)
Query Neighborhood Hits	396	Target Neighborhood Hits	609	Shared Neighborhood Hits	45
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CHD4_HUMAN
θ value	4.03905 (rank : 302)	NC score	0.009836 (rank : 579)
Query Neighborhood Hits	396	Target Neighborhood Hits	365	Shared Neighborhood Hits	25
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	4.03905 (rank : 303)	NC score	0.011345 (rank : 573)
Query Neighborhood Hits	396	Target Neighborhood Hits	408	Shared Neighborhood Hits	31
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

FMN2_HUMAN
θ value	4.03905 (rank : 304)	NC score	0.025450 (rank : 526)
Query Neighborhood Hits	396	Target Neighborhood Hits	484	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

PCDA2_HUMAN
θ value	4.03905 (rank : 305)	NC score	-0.002222 (rank : 598)
Query Neighborhood Hits	396	Target Neighborhood Hits	192	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5H9, O75287, Q9BTV3	Gene names	PCDHA2
Domain Architecture
Description	Protocadherin alpha 2 precursor (PCDH-alpha2).

RUSC1_MOUSE
θ value	4.03905 (rank : 306)	NC score	0.267235 (rank : 127)
Query Neighborhood Hits	396	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SETD2_HUMAN
θ value	4.03905 (rank : 307)	NC score	0.024895 (rank : 527)
Query Neighborhood Hits	396	Target Neighborhood Hits	412	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SMC1A_HUMAN
θ value	4.03905 (rank : 308)	NC score	0.040781 (rank : 481)
Query Neighborhood Hits	396	Target Neighborhood Hits	1346	Shared Neighborhood Hits	82
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	4.03905 (rank : 309)	NC score	0.041165 (rank : 479)
Query Neighborhood Hits	396	Target Neighborhood Hits	1384	Shared Neighborhood Hits	85
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SPT5H_HUMAN
θ value	4.03905 (rank : 310)	NC score	0.039363 (rank : 485)
Query Neighborhood Hits	396	Target Neighborhood Hits	436	Shared Neighborhood Hits	44
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	4.03905 (rank : 311)	NC score	0.038230 (rank : 490)
Query Neighborhood Hits	396	Target Neighborhood Hits	437	Shared Neighborhood Hits	43
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

TARA_MOUSE
θ value	4.03905 (rank : 312)	NC score	0.044933 (rank : 470)
Query Neighborhood Hits	396	Target Neighborhood Hits	1133	Shared Neighborhood Hits	92
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TBX2_MOUSE
θ value	4.03905 (rank : 313)	NC score	0.011790 (rank : 570)
Query Neighborhood Hits	396	Target Neighborhood Hits	97	Shared Neighborhood Hits	12
SwissProt Accessions	Q60707	Gene names	Tbx2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

TGON2_HUMAN
θ value	4.03905 (rank : 314)	NC score	0.050428 (rank : 447)
Query Neighborhood Hits	396	Target Neighborhood Hits	1037	Shared Neighborhood Hits	95
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ADDA_MOUSE
θ value	5.27518 (rank : 315)	NC score	0.020287 (rank : 536)
Query Neighborhood Hits	396	Target Neighborhood Hits	198	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

ANR11_HUMAN
θ value	5.27518 (rank : 316)	NC score	0.038616 (rank : 488)
Query Neighborhood Hits	396	Target Neighborhood Hits	1289	Shared Neighborhood Hits	104
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ARHG1_HUMAN
θ value	5.27518 (rank : 317)	NC score	0.128512 (rank : 232)
Query Neighborhood Hits	396	Target Neighborhood Hits	176	Shared Neighborhood Hits	32
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

BCL9_HUMAN
θ value	5.27518 (rank : 318)	NC score	0.027517 (rank : 519)
Query Neighborhood Hits	396	Target Neighborhood Hits	1008	Shared Neighborhood Hits	67
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BI2L1_HUMAN
θ value	5.27518 (rank : 319)	NC score	0.167556 (rank : 192)
Query Neighborhood Hits	396	Target Neighborhood Hits	156	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BRSK1_HUMAN
θ value	5.27518 (rank : 320)	NC score	0.025642 (rank : 525)
Query Neighborhood Hits	396	Target Neighborhood Hits	942	Shared Neighborhood Hits	60
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

CSKP_MOUSE
θ value	5.27518 (rank : 321)	NC score	0.054856 (rank : 412)
Query Neighborhood Hits	396	Target Neighborhood Hits	1027	Shared Neighborhood Hits	137
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

EBP2_MOUSE
θ value	5.27518 (rank : 322)	NC score	0.019544 (rank : 541)
Query Neighborhood Hits	396	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D903, Q3TKB5	Gene names	Ebna1bp2, Ebp2
Domain Architecture
Description	Probable rRNA-processing protein EBP2.

EF1D_MOUSE
θ value	5.27518 (rank : 323)	NC score	0.021794 (rank : 533)
Query Neighborhood Hits	396	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	P57776, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5	Gene names	Eef1d
Domain Architecture
Description	Elongation factor 1-delta (EF-1-delta).

ELOA1_MOUSE
θ value	5.27518 (rank : 324)	NC score	0.015935 (rank : 558)
Query Neighborhood Hits	396	Target Neighborhood Hits	152	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CB77, Q80VB2, Q9R0Q5	Gene names	Tceb3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

HXC10_MOUSE
θ value	5.27518 (rank : 325)	NC score	0.003051 (rank : 592)
Query Neighborhood Hits	396	Target Neighborhood Hits	417	Shared Neighborhood Hits	21
SwissProt Accessions	P31257, P31312, Q7TMT7	Gene names	Hoxc10, Hox-3.6, Hoxc-10
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C10 (Hox-3.6).

LIPB2_MOUSE
θ value	5.27518 (rank : 326)	NC score	0.014955 (rank : 561)
Query Neighborhood Hits	396	Target Neighborhood Hits	570	Shared Neighborhood Hits	33
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

LPIN2_MOUSE
θ value	5.27518 (rank : 327)	NC score	0.008989 (rank : 582)
Query Neighborhood Hits	396	Target Neighborhood Hits	60	Shared Neighborhood Hits	9
SwissProt Accessions	Q99PI5, Q8C357, Q8C7I8, Q8CC85, Q8CHR7	Gene names	Lpin2
Domain Architecture
Description	Lipin-2.

MARE2_HUMAN
θ value	5.27518 (rank : 328)	NC score	0.009497 (rank : 581)
Query Neighborhood Hits	396	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q15555, Q9UQ33	Gene names	MAPRE2, RP1
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2).

MPP6_HUMAN
θ value	5.27518 (rank : 329)	NC score	0.105724 (rank : 283)
Query Neighborhood Hits	396	Target Neighborhood Hits	180	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	5.27518 (rank : 330)	NC score	0.101620 (rank : 294)
Query Neighborhood Hits	396	Target Neighborhood Hits	187	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MYH7_HUMAN
θ value	5.27518 (rank : 331)	NC score	0.034512 (rank : 504)
Query Neighborhood Hits	396	Target Neighborhood Hits	1559	Shared Neighborhood Hits	71
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

OAS3_HUMAN
θ value	5.27518 (rank : 332)	NC score	0.009638 (rank : 580)
Query Neighborhood Hits	396	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6K5, Q9H3P5	Gene names	OAS3
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 3 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 3) (2-5A synthetase 3) (p100 OAS) (p100OAS).

OXR1_MOUSE
θ value	5.27518 (rank : 333)	NC score	0.035657 (rank : 501)
Query Neighborhood Hits	396	Target Neighborhood Hits	516	Shared Neighborhood Hits	51
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

PASK_MOUSE
θ value	5.27518 (rank : 334)	NC score	0.019603 (rank : 540)
Query Neighborhood Hits	396	Target Neighborhood Hits	867	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PTK6_MOUSE
θ value	5.27518 (rank : 335)	NC score	0.122703 (rank : 241)
Query Neighborhood Hits	396	Target Neighborhood Hits	1026	Shared Neighborhood Hits	161
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SASH1_HUMAN
θ value	5.27518 (rank : 336)	NC score	0.114180 (rank : 262)
Query Neighborhood Hits	396	Target Neighborhood Hits	292	Shared Neighborhood Hits	73
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	5.27518 (rank : 337)	NC score	0.109710 (rank : 270)
Query Neighborhood Hits	396	Target Neighborhood Hits	263	Shared Neighborhood Hits	69
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SNIP_MOUSE
θ value	5.27518 (rank : 338)	NC score	0.020012 (rank : 537)
Query Neighborhood Hits	396	Target Neighborhood Hits	319	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

SON_HUMAN
θ value	5.27518 (rank : 339)	NC score	0.042571 (rank : 476)
Query Neighborhood Hits	396	Target Neighborhood Hits	1568	Shared Neighborhood Hits	114
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

TEC_MOUSE
θ value	5.27518 (rank : 340)	NC score	0.120013 (rank : 245)
Query Neighborhood Hits	396	Target Neighborhood Hits	1006	Shared Neighborhood Hits	149
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZBT11_HUMAN
θ value	5.27518 (rank : 341)	NC score	-0.009006 (rank : 600)
Query Neighborhood Hits	396	Target Neighborhood Hits	873	Shared Neighborhood Hits	12
SwissProt Accessions	O95625	Gene names	ZBTB11
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 11.

ACK1_HUMAN
θ value	6.88961 (rank : 342)	NC score	0.070704 (rank : 374)
Query Neighborhood Hits	396	Target Neighborhood Hits	1140	Shared Neighborhood Hits	112
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	6.88961 (rank : 343)	NC score	0.071201 (rank : 373)
Query Neighborhood Hits	396	Target Neighborhood Hits	1080	Shared Neighborhood Hits	112
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

CAR10_MOUSE
θ value	6.88961 (rank : 344)	NC score	0.018091 (rank : 549)
Query Neighborhood Hits	396	Target Neighborhood Hits	407	Shared Neighborhood Hits	25
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

CC28A_HUMAN
θ value	6.88961 (rank : 345)	NC score	0.014098 (rank : 564)
Query Neighborhood Hits	396	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWP9, Q66K67, Q96E23, Q9Y430	Gene names	CCDC28A, C6orf80
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 28A (CCRL1AP).

CNOT4_HUMAN
θ value	6.88961 (rank : 346)	NC score	0.016082 (rank : 556)
Query Neighborhood Hits	396	Target Neighborhood Hits	207	Shared Neighborhood Hits	14
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CSKI2_MOUSE
θ value	6.88961 (rank : 347)	NC score	0.040477 (rank : 482)
Query Neighborhood Hits	396	Target Neighborhood Hits	812	Shared Neighborhood Hits	93
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKP_HUMAN
θ value	6.88961 (rank : 348)	NC score	0.054826 (rank : 413)
Query Neighborhood Hits	396	Target Neighborhood Hits	1022	Shared Neighborhood Hits	130
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DLX4_HUMAN
θ value	6.88961 (rank : 349)	NC score	-0.000271 (rank : 597)
Query Neighborhood Hits	396	Target Neighborhood Hits	350	Shared Neighborhood Hits	10
SwissProt Accessions	Q92988, O60480, Q13265, Q6PJK0, Q9HBE0	Gene names	DLX4, BP1, DLX7, DLX8
Domain Architecture	No domain graphic available
Description	Homeobox protein DLX-4 (DLX-7) (DLX-8) (Beta protein 1).

DYXC1_MOUSE
θ value	6.88961 (rank : 350)	NC score	0.014404 (rank : 563)
Query Neighborhood Hits	396	Target Neighborhood Hits	172	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R368	Gene names	Dyx1c1, Ekn1
Domain Architecture
Description	Dyslexia susceptibility 1 candidate gene 1 protein homolog.

GGN_HUMAN
θ value	6.88961 (rank : 351)	NC score	0.043972 (rank : 472)
Query Neighborhood Hits	396	Target Neighborhood Hits	269	Shared Neighborhood Hits	37
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GMIP_HUMAN
θ value	6.88961 (rank : 352)	NC score	0.067174 (rank : 381)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

ICAL_HUMAN
θ value	6.88961 (rank : 353)	NC score	0.028760 (rank : 514)
Query Neighborhood Hits	396	Target Neighborhood Hits	275	Shared Neighborhood Hits	35
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

IRS2_MOUSE
θ value	6.88961 (rank : 354)	NC score	0.018563 (rank : 543)
Query Neighborhood Hits	396	Target Neighborhood Hits	248	Shared Neighborhood Hits	31
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

K0323_HUMAN
θ value	6.88961 (rank : 355)	NC score	0.011874 (rank : 569)
Query Neighborhood Hits	396	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	O15037, Q86TZ6, Q8IUQ2, Q96BA9	Gene names	KIAA0323
Domain Architecture	No domain graphic available
Description	Protein KIAA0323.

KIF9_MOUSE
θ value	6.88961 (rank : 356)	NC score	0.002514 (rank : 593)
Query Neighborhood Hits	396	Target Neighborhood Hits	147	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WV04, O35070	Gene names	Kif9
Domain Architecture
Description	Kinesin-like protein KIF9.

MAML2_HUMAN
θ value	6.88961 (rank : 357)	NC score	0.030594 (rank : 513)
Query Neighborhood Hits	396	Target Neighborhood Hits	360	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

MMAC_HUMAN
θ value	6.88961 (rank : 358)	NC score	0.015929 (rank : 559)
Query Neighborhood Hits	396	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4U1, Q5T157, Q9BRQ7	Gene names	MMACHC
Domain Architecture	No domain graphic available
Description	Methylmalonic aciduria and homocystinuria type C protein.

MPP5_HUMAN
θ value	6.88961 (rank : 359)	NC score	0.080216 (rank : 339)
Query Neighborhood Hits	396	Target Neighborhood Hits	231	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	6.88961 (rank : 360)	NC score	0.079428 (rank : 343)
Query Neighborhood Hits	396	Target Neighborhood Hits	226	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

NOC2L_HUMAN
θ value	6.88961 (rank : 361)	NC score	0.011554 (rank : 571)
Query Neighborhood Hits	396	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y3T9, Q5SVA3, Q9BTN6	Gene names	NOC2L
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

NPBL_MOUSE
θ value	6.88961 (rank : 362)	NC score	0.050595 (rank : 446)
Query Neighborhood Hits	396	Target Neighborhood Hits	1041	Shared Neighborhood Hits	77
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PEX13_MOUSE
θ value	6.88961 (rank : 363)	NC score	0.316064 (rank : 111)
Query Neighborhood Hits	396	Target Neighborhood Hits	126	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RGS3_MOUSE
θ value	6.88961 (rank : 364)	NC score	0.043739 (rank : 473)
Query Neighborhood Hits	396	Target Neighborhood Hits	1621	Shared Neighborhood Hits	120
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RP3A_MOUSE
θ value	6.88961 (rank : 365)	NC score	0.022917 (rank : 530)
Query Neighborhood Hits	396	Target Neighborhood Hits	510	Shared Neighborhood Hits	37
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SAMN1_MOUSE
θ value	6.88961 (rank : 366)	NC score	0.100744 (rank : 295)
Query Neighborhood Hits	396	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SNTG2_HUMAN
θ value	6.88961 (rank : 367)	NC score	0.005469 (rank : 589)
Query Neighborhood Hits	396	Target Neighborhood Hits	191	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

WDR60_MOUSE
θ value	6.88961 (rank : 368)	NC score	0.027797 (rank : 518)
Query Neighborhood Hits	396	Target Neighborhood Hits	344	Shared Neighborhood Hits	38
SwissProt Accessions	Q8C761, Q3UNM4	Gene names	Wdr60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

XRCC3_MOUSE
θ value	6.88961 (rank : 369)	NC score	0.010061 (rank : 577)
Query Neighborhood Hits	396	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CXE6	Gene names	Xrcc3
Domain Architecture	No domain graphic available
Description	DNA-repair protein XRCC3 (X-ray repair cross-complementing protein 3).

ZC313_HUMAN
θ value	6.88961 (rank : 370)	NC score	0.048807 (rank : 465)
Query Neighborhood Hits	396	Target Neighborhood Hits	772	Shared Neighborhood Hits	64
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

AFF1_HUMAN
θ value	8.99809 (rank : 371)	NC score	0.043563 (rank : 474)
Query Neighborhood Hits	396	Target Neighborhood Hits	506	Shared Neighborhood Hits	52
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

ARHG4_MOUSE
θ value	8.99809 (rank : 372)	NC score	0.292476 (rank : 119)
Query Neighborhood Hits	396	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ATF4_HUMAN
θ value	8.99809 (rank : 373)	NC score	0.010933 (rank : 575)
Query Neighborhood Hits	396	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P18848, Q9UH31	Gene names	ATF4
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-4 (Activating transcription factor 4) (DNA-binding protein TAXREB67) (Cyclic AMP response element-binding protein 2) (CREB2).

CAC1B_HUMAN
θ value	8.99809 (rank : 374)	NC score	0.003892 (rank : 590)
Query Neighborhood Hits	396	Target Neighborhood Hits	257	Shared Neighborhood Hits	19
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CLIC6_HUMAN
θ value	8.99809 (rank : 375)	NC score	0.007401 (rank : 586)
Query Neighborhood Hits	396	Target Neighborhood Hits	289	Shared Neighborhood Hits	18
SwissProt Accessions	Q96NY7, Q8IX31	Gene names	CLIC6, CLIC1L
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

CNOT4_MOUSE
θ value	8.99809 (rank : 376)	NC score	0.018559 (rank : 544)
Query Neighborhood Hits	396	Target Neighborhood Hits	277	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CT2NL_MOUSE
θ value	8.99809 (rank : 377)	NC score	0.031742 (rank : 510)
Query Neighborhood Hits	396	Target Neighborhood Hits	902	Shared Neighborhood Hits	60
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

DCX_HUMAN
θ value	8.99809 (rank : 378)	NC score	0.008690 (rank : 583)
Query Neighborhood Hits	396	Target Neighborhood Hits	141	Shared Neighborhood Hits	18
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DMD_HUMAN
θ value	8.99809 (rank : 379)	NC score	0.033765 (rank : 507)
Query Neighborhood Hits	396	Target Neighborhood Hits	1135	Shared Neighborhood Hits	60
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	8.99809 (rank : 380)	NC score	0.031262 (rank : 512)
Query Neighborhood Hits	396	Target Neighborhood Hits	1111	Shared Neighborhood Hits	60
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DUX4_HUMAN
θ value	8.99809 (rank : 381)	NC score	0.000370 (rank : 596)
Query Neighborhood Hits	396	Target Neighborhood Hits	403	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UBX2	Gene names	DUX4, DUX10
Domain Architecture	No domain graphic available
Description	Double homeobox protein 4 (Double homeobox protein 10) (Double homeobox protein 4/10).

HXC10_HUMAN
θ value	8.99809 (rank : 382)	NC score	0.002020 (rank : 594)
Query Neighborhood Hits	396	Target Neighborhood Hits	417	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

KIF4A_MOUSE
θ value	8.99809 (rank : 383)	NC score	0.018467 (rank : 546)
Query Neighborhood Hits	396	Target Neighborhood Hits	1033	Shared Neighborhood Hits	51
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MAVS_MOUSE
θ value	8.99809 (rank : 384)	NC score	0.019899 (rank : 538)
Query Neighborhood Hits	396	Target Neighborhood Hits	170	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

MPP2_MOUSE
θ value	8.99809 (rank : 385)	NC score	0.070133 (rank : 375)
Query Neighborhood Hits	396	Target Neighborhood Hits	189	Shared Neighborhood Hits	70
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

NFRKB_MOUSE
θ value	8.99809 (rank : 386)	NC score	0.022810 (rank : 531)
Query Neighborhood Hits	396	Target Neighborhood Hits	393	Shared Neighborhood Hits	34
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

RED_HUMAN
θ value	8.99809 (rank : 387)	NC score	0.013073 (rank : 567)
Query Neighborhood Hits	396	Target Neighborhood Hits	79	Shared Neighborhood Hits	9
SwissProt Accessions	Q13123	Gene names	IK, RED, RER
Domain Architecture	No domain graphic available
Description	Protein Red (Protein RER) (IK factor) (Cytokine IK).

RHG12_HUMAN
θ value	8.99809 (rank : 388)	NC score	0.096360 (rank : 302)
Query Neighborhood Hits	396	Target Neighborhood Hits	190	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RT31_HUMAN
θ value	8.99809 (rank : 389)	NC score	0.011145 (rank : 574)
Query Neighborhood Hits	396	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q92665, Q5VYC8, Q8WTV8	Gene names	MRPS31, IMOGN38
Domain Architecture	No domain graphic available
Description	28S ribosomal protein S31, mitochondrial precursor (S31mt) (MRP-S31) (Imogen 38).

SPEG_HUMAN
θ value	8.99809 (rank : 390)	NC score	0.026694 (rank : 523)
Query Neighborhood Hits	396	Target Neighborhood Hits	1762	Shared Neighborhood Hits	104
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STAR8_HUMAN
θ value	8.99809 (rank : 391)	NC score	0.046871 (rank : 468)
Query Neighborhood Hits	396	Target Neighborhood Hits	216	Shared Neighborhood Hits	31
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STK10_HUMAN
θ value	8.99809 (rank : 392)	NC score	0.034404 (rank : 506)
Query Neighborhood Hits	396	Target Neighborhood Hits	1921	Shared Neighborhood Hits	109
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TEC_HUMAN
θ value	8.99809 (rank : 393)	NC score	0.123601 (rank : 238)
Query Neighborhood Hits	396	Target Neighborhood Hits	1006	Shared Neighborhood Hits	151
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEF_MOUSE
θ value	8.99809 (rank : 394)	NC score	0.013365 (rank : 566)
Query Neighborhood Hits	396	Target Neighborhood Hits	68	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JLC6, Q3U426, Q3UGF4, Q3UM49, Q3URC8, Q6QHT6, Q8C6I0, Q8VD02	Gene names	Tef
Domain Architecture	No domain graphic available
Description	Thyrotroph embryonic factor.

TEX14_HUMAN
θ value	8.99809 (rank : 395)	NC score	0.065997 (rank : 383)
Query Neighborhood Hits	396	Target Neighborhood Hits	1103	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TNIK_HUMAN
θ value	8.99809 (rank : 396)	NC score	0.031448 (rank : 511)
Query Neighborhood Hits	396	Target Neighborhood Hits	1570	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

3BP1_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.091711 (rank : 308)
Query Neighborhood Hits	396	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

3BP1_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.063362 (rank : 389)
Query Neighborhood Hits	396	Target Neighborhood Hits	238	Shared Neighborhood Hits	42
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AATK_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.051056 (rank : 442)
Query Neighborhood Hits	396	Target Neighborhood Hits	1243	Shared Neighborhood Hits	79
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.052602 (rank : 432)
Query Neighborhood Hits	396	Target Neighborhood Hits	942	Shared Neighborhood Hits	62
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.119254 (rank : 248)
Query Neighborhood Hits	396	Target Neighborhood Hits	1220	Shared Neighborhood Hits	158
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.118877 (rank : 249)
Query Neighborhood Hits	396	Target Neighborhood Hits	1178	Shared Neighborhood Hits	158
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.114205 (rank : 261)
Query Neighborhood Hits	396	Target Neighborhood Hits	1045	Shared Neighborhood Hits	135
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABR_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.107541 (rank : 278)
Query Neighborhood Hits	396	Target Neighborhood Hits	166	Shared Neighborhood Hits	43
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ALK_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.052856 (rank : 430)
Query Neighborhood Hits	396	Target Neighborhood Hits	795	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.053612 (rank : 421)
Query Neighborhood Hits	396	Target Neighborhood Hits	811	Shared Neighborhood Hits	52
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

APS_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.115767 (rank : 258)
Query Neighborhood Hits	396	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.085684 (rank : 321)
Query Neighborhood Hits	396	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.116402 (rank : 256)
Query Neighborhood Hits	396	Target Neighborhood Hits	266	Shared Neighborhood Hits	32
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.103618 (rank : 288)
Query Neighborhood Hits	396	Target Neighborhood Hits	142	Shared Neighborhood Hits	31
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.098151 (rank : 300)
Query Neighborhood Hits	396	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.162809 (rank : 198)
Query Neighborhood Hits	396	Target Neighborhood Hits	82	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.162676 (rank : 199)
Query Neighborhood Hits	396	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.149408 (rank : 213)
Query Neighborhood Hits	396	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.159159 (rank : 204)
Query Neighborhood Hits	396	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.128520 (rank : 231)
Query Neighborhood Hits	396	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.130602 (rank : 230)
Query Neighborhood Hits	396	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.117901 (rank : 251)
Query Neighborhood Hits	396	Target Neighborhood Hits	375	Shared Neighborhood Hits	47
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.116863 (rank : 254)
Query Neighborhood Hits	396	Target Neighborhood Hits	351	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.117232 (rank : 253)
Query Neighborhood Hits	396	Target Neighborhood Hits	344	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.133804 (rank : 227)
Query Neighborhood Hits	396	Target Neighborhood Hits	214	Shared Neighborhood Hits	48
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

BCAR3_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.080435 (rank : 338)
Query Neighborhood Hits	396	Target Neighborhood Hits	129	Shared Neighborhood Hits	41
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.080132 (rank : 340)
Query Neighborhood Hits	396	Target Neighborhood Hits	127	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.118113 (rank : 250)
Query Neighborhood Hits	396	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BLNK_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.069897 (rank : 377)
Query Neighborhood Hits	396	Target Neighborhood Hits	228	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.073984 (rank : 354)
Query Neighborhood Hits	396	Target Neighborhood Hits	296	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMX_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.073694 (rank : 357)
Query Neighborhood Hits	396	Target Neighborhood Hits	942	Shared Neighborhood Hits	68
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.073698 (rank : 356)
Query Neighborhood Hits	396	Target Neighborhood Hits	912	Shared Neighborhood Hits	68
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CHIN_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.107013 (rank : 280)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.109587 (rank : 271)
Query Neighborhood Hits	396	Target Neighborhood Hits	229	Shared Neighborhood Hits	61
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.106841 (rank : 281)
Query Neighborhood Hits	396	Target Neighborhood Hits	220	Shared Neighborhood Hits	55
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.075215 (rank : 352)
Query Neighborhood Hits	396	Target Neighborhood Hits	130	Shared Neighborhood Hits	27
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.164869 (rank : 193)
Query Neighborhood Hits	396	Target Neighborhood Hits	374	Shared Neighborhood Hits	91
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CISH_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.069959 (rank : 376)
Query Neighborhood Hits	396	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CISH_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.069253 (rank : 378)
Query Neighborhood Hits	396	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

DAPP1_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.142359 (rank : 218)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.145082 (rank : 215)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDR1_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.051400 (rank : 439)
Query Neighborhood Hits	396	Target Neighborhood Hits	819	Shared Neighborhood Hits	47
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.051856 (rank : 438)
Query Neighborhood Hits	396	Target Neighborhood Hits	818	Shared Neighborhood Hits	47
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DLG2_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.050013 (rank : 460)
Query Neighborhood Hits	396	Target Neighborhood Hits	271	Shared Neighborhood Hits	75
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DOCK2_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.097002 (rank : 301)
Query Neighborhood Hits	396	Target Neighborhood Hits	104	Shared Neighborhood Hits	45
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DUET_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.060775 (rank : 394)
Query Neighborhood Hits	396	Target Neighborhood Hits	1220	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ECT2_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.132091 (rank : 229)
Query Neighborhood Hits	396	Target Neighborhood Hits	98	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.136171 (rank : 224)
Query Neighborhood Hits	396	Target Neighborhood Hits	98	Shared Neighborhood Hits	29
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EPHAA_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.051054 (rank : 443)
Query Neighborhood Hits	396	Target Neighborhood Hits	960	Shared Neighborhood Hits	52
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.050716 (rank : 444)
Query Neighborhood Hits	396	Target Neighborhood Hits	912	Shared Neighborhood Hits	50
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.050359 (rank : 451)
Query Neighborhood Hits	396	Target Neighborhood Hits	1073	Shared Neighborhood Hits	55
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.050103 (rank : 456)
Query Neighborhood Hits	396	Target Neighborhood Hits	918	Shared Neighborhood Hits	48
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.050188 (rank : 455)
Query Neighborhood Hits	396	Target Neighborhood Hits	918	Shared Neighborhood Hits	44
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.050039 (rank : 457)
Query Neighborhood Hits	396	Target Neighborhood Hits	898	Shared Neighborhood Hits	48
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.050349 (rank : 452)
Query Neighborhood Hits	396	Target Neighborhood Hits	910	Shared Neighborhood Hits	50
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L1_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.178649 (rank : 182)
Query Neighborhood Hits	396	Target Neighborhood Hits	162	Shared Neighborhood Hits	104
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.183265 (rank : 174)
Query Neighborhood Hits	396	Target Neighborhood Hits	143	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.200954 (rank : 167)
Query Neighborhood Hits	396	Target Neighborhood Hits	193	Shared Neighborhood Hits	125
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.202810 (rank : 163)
Query Neighborhood Hits	396	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FAK2_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.050420 (rank : 448)
Query Neighborhood Hits	396	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.050392 (rank : 450)
Query Neighborhood Hits	396	Target Neighborhood Hits	851	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FARP1_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.071335 (rank : 372)
Query Neighborhood Hits	396	Target Neighborhood Hits	241	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.073082 (rank : 362)
Query Neighborhood Hits	396	Target Neighborhood Hits	240	Shared Neighborhood Hits	33
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.083748 (rank : 327)
Query Neighborhood Hits	396	Target Neighborhood Hits	209	Shared Neighborhood Hits	36
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.079988 (rank : 341)
Query Neighborhood Hits	396	Target Neighborhood Hits	1278	Shared Neighborhood Hits	104
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.058848 (rank : 397)
Query Neighborhood Hits	396	Target Neighborhood Hits	978	Shared Neighborhood Hits	66
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.055879 (rank : 406)
Query Neighborhood Hits	396	Target Neighborhood Hits	980	Shared Neighborhood Hits	62
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.093058 (rank : 306)
Query Neighborhood Hits	396	Target Neighborhood Hits	367	Shared Neighborhood Hits	48
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.089389 (rank : 312)
Query Neighborhood Hits	396	Target Neighborhood Hits	387	Shared Neighborhood Hits	44
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.099238 (rank : 297)
Query Neighborhood Hits	396	Target Neighborhood Hits	151	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.094218 (rank : 304)
Query Neighborhood Hits	396	Target Neighborhood Hits	163	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.101704 (rank : 293)
Query Neighborhood Hits	396	Target Neighborhood Hits	249	Shared Neighborhood Hits	31
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.109443 (rank : 272)
Query Neighborhood Hits	396	Target Neighborhood Hits	257	Shared Neighborhood Hits	35
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.104654 (rank : 287)
Query Neighborhood Hits	396	Target Neighborhood Hits	219	Shared Neighborhood Hits	33
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.105118 (rank : 286)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.075199 (rank : 353)
Query Neighborhood Hits	396	Target Neighborhood Hits	237	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.086056 (rank : 320)
Query Neighborhood Hits	396	Target Neighborhood Hits	282	Shared Neighborhood Hits	43
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FLT3_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.050029 (rank : 458)
Query Neighborhood Hits	396	Target Neighborhood Hits	843	Shared Neighborhood Hits	45
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.050305 (rank : 453)
Query Neighborhood Hits	396	Target Neighborhood Hits	847	Shared Neighborhood Hits	46
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

GNRP_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.100300 (rank : 296)
Query Neighborhood Hits	396	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.108715 (rank : 275)
Query Neighborhood Hits	396	Target Neighborhood Hits	191	Shared Neighborhood Hits	33
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.082349 (rank : 333)
Query Neighborhood Hits	396	Target Neighborhood Hits	147	Shared Neighborhood Hits	49
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.083302 (rank : 330)
Query Neighborhood Hits	396	Target Neighborhood Hits	156	Shared Neighborhood Hits	47
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.110399 (rank : 269)
Query Neighborhood Hits	396	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.113956 (rank : 263)
Query Neighborhood Hits	396	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.089312 (rank : 313)
Query Neighborhood Hits	396	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.101736 (rank : 292)
Query Neighborhood Hits	396	Target Neighborhood Hits	157	Shared Neighborhood Hits	54
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GSCR1_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.050236 (rank : 454)
Query Neighborhood Hits	396	Target Neighborhood Hits	674	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HAPIP_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.111209 (rank : 266)
Query Neighborhood Hits	396	Target Neighborhood Hits	350	Shared Neighborhood Hits	39
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HSH2D_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.107101 (rank : 279)
Query Neighborhood Hits	396	Target Neighborhood Hits	159	Shared Neighborhood Hits	47
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.077562 (rank : 348)
Query Neighborhood Hits	396	Target Neighborhood Hits	124	Shared Neighborhood Hits	32
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ILK1_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.057859 (rank : 399)
Query Neighborhood Hits	396	Target Neighborhood Hits	857	Shared Neighborhood Hits	58
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.057186 (rank : 403)
Query Neighborhood Hits	396	Target Neighborhood Hits	848	Shared Neighborhood Hits	58
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.058098 (rank : 398)
Query Neighborhood Hits	396	Target Neighborhood Hits	858	Shared Neighborhood Hits	58
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ITK_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.111387 (rank : 265)
Query Neighborhood Hits	396	Target Neighborhood Hits	1016	Shared Neighborhood Hits	143
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.103291 (rank : 290)
Query Neighborhood Hits	396	Target Neighborhood Hits	985	Shared Neighborhood Hits	129
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KSYK_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.071372 (rank : 371)
Query Neighborhood Hits	396	Target Neighborhood Hits	901	Shared Neighborhood Hits	70
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.073450 (rank : 360)
Query Neighborhood Hits	396	Target Neighborhood Hits	944	Shared Neighborhood Hits	78
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.103451 (rank : 289)
Query Neighborhood Hits	396	Target Neighborhood Hits	90	Shared Neighborhood Hits	23
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.081762 (rank : 335)
Query Neighborhood Hits	396	Target Neighborhood Hits	531	Shared Neighborhood Hits	81
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.084417 (rank : 322)
Query Neighborhood Hits	396	Target Neighborhood Hits	177	Shared Neighborhood Hits	51
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LMO7_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.057516 (rank : 402)
Query Neighborhood Hits	396	Target Neighborhood Hits	507	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LNK_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.105267 (rank : 285)
Query Neighborhood Hits	396	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.106090 (rank : 282)
Query Neighborhood Hits	396	Target Neighborhood Hits	132	Shared Neighborhood Hits	44
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LTK_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.054465 (rank : 415)
Query Neighborhood Hits	396	Target Neighborhood Hits	774	Shared Neighborhood Hits	46
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.053980 (rank : 419)
Query Neighborhood Hits	396	Target Neighborhood Hits	770	Shared Neighborhood Hits	47
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

MATK_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.091626 (rank : 309)
Query Neighborhood Hits	396	Target Neighborhood Hits	954	Shared Neighborhood Hits	90
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MCF2L_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.156406 (rank : 206)
Query Neighborhood Hits	396	Target Neighborhood Hits	255	Shared Neighborhood Hits	56
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.133056 (rank : 228)
Query Neighborhood Hits	396	Target Neighborhood Hits	166	Shared Neighborhood Hits	34
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MDC1_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.055220 (rank : 409)
Query Neighborhood Hits	396	Target Neighborhood Hits	998	Shared Neighborhood Hits	86
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MIA_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.052540 (rank : 433)
Query Neighborhood Hits	396	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	θ > 10 (rank : 508)	NC score	0.052626 (rank : 431)
Query Neighborhood Hits	396	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MPP2_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.068991 (rank : 379)
Query Neighborhood Hits	396	Target Neighborhood Hits	173	Shared Neighborhood Hits	70
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP4_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.057073 (rank : 404)
Query Neighborhood Hits	396	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.063087 (rank : 390)
Query Neighborhood Hits	396	Target Neighborhood Hits	188	Shared Neighborhood Hits	65
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MYO9B_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.052292 (rank : 435)
Query Neighborhood Hits	396	Target Neighborhood Hits	641	Shared Neighborhood Hits	66
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NOXO1_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.199316 (rank : 168)
Query Neighborhood Hits	396	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.273590 (rank : 125)
Query Neighborhood Hits	396	Target Neighborhood Hits	114	Shared Neighborhood Hits	102
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NRAP_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.071469 (rank : 369)
Query Neighborhood Hits	396	Target Neighborhood Hits	159	Shared Neighborhood Hits	9
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NRAP_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.072062 (rank : 366)
Query Neighborhood Hits	396	Target Neighborhood Hits	167	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

OPHN1_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.064456 (rank : 386)
Query Neighborhood Hits	396	Target Neighborhood Hits	161	Shared Neighborhood Hits	27
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.061589 (rank : 393)
Query Neighborhood Hits	396	Target Neighborhood Hits	174	Shared Neighborhood Hits	27
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

P55G_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.171008 (rank : 190)
Query Neighborhood Hits	396	Target Neighborhood Hits	451	Shared Neighborhood Hits	76
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.170487 (rank : 191)
Query Neighborhood Hits	396	Target Neighborhood Hits	401	Shared Neighborhood Hits	73
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PEX13_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.310667 (rank : 115)
Query Neighborhood Hits	396	Target Neighborhood Hits	128	Shared Neighborhood Hits	113
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHG1_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.174224 (rank : 187)
Query Neighborhood Hits	396	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.081528 (rank : 336)
Query Neighborhood Hits	396	Target Neighborhood Hits	200	Shared Neighborhood Hits	28
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PPIP2_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.091715 (rank : 307)
Query Neighborhood Hits	396	Target Neighborhood Hits	254	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.083478 (rank : 329)
Query Neighborhood Hits	396	Target Neighborhood Hits	308	Shared Neighborhood Hits	34
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.160149 (rank : 202)
Query Neighborhood Hits	396	Target Neighborhood Hits	177	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTK6_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.120087 (rank : 244)
Query Neighborhood Hits	396	Target Neighborhood Hits	1020	Shared Neighborhood Hits	163
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTN11_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.084070 (rank : 325)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.084082 (rank : 324)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.071476 (rank : 368)
Query Neighborhood Hits	396	Target Neighborhood Hits	234	Shared Neighborhood Hits	57
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.073212 (rank : 361)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.163047 (rank : 197)
Query Neighborhood Hits	396	Target Neighborhood Hits	258	Shared Neighborhood Hits	76
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

REPS2_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.059931 (rank : 396)
Query Neighborhood Hits	396	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.056072 (rank : 405)
Query Neighborhood Hits	396	Target Neighborhood Hits	102	Shared Neighborhood Hits	15
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGAP1_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.051067 (rank : 441)
Query Neighborhood Hits	396	Target Neighborhood Hits	185	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGNEF_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.108617 (rank : 277)
Query Neighborhood Hits	396	Target Neighborhood Hits	641	Shared Neighborhood Hits	64
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG06_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.051314 (rank : 440)
Query Neighborhood Hits	396	Target Neighborhood Hits	114	Shared Neighborhood Hits	23
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG25_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.055460 (rank : 407)
Query Neighborhood Hits	396	Target Neighborhood Hits	550	Shared Neighborhood Hits	45
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.064321 (rank : 388)
Query Neighborhood Hits	396	Target Neighborhood Hits	492	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ROS_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.053012 (rank : 427)
Query Neighborhood Hits	396	Target Neighborhood Hits	907	Shared Neighborhood Hits	50
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RUSC2_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.108722 (rank : 274)
Query Neighborhood Hits	396	Target Neighborhood Hits	205	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.089246 (rank : 314)
Query Neighborhood Hits	396	Target Neighborhood Hits	305	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RYK_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.054752 (rank : 414)
Query Neighborhood Hits	396	Target Neighborhood Hits	701	Shared Neighborhood Hits	42
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.054151 (rank : 417)
Query Neighborhood Hits	396	Target Neighborhood Hits	715	Shared Neighborhood Hits	42
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

S3TC2_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.053084 (rank : 425)
Query Neighborhood Hits	396	Target Neighborhood Hits	83	Shared Neighborhood Hits	47
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

SH21A_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.088131 (rank : 318)
Query Neighborhood Hits	396	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.089080 (rank : 315)
Query Neighborhood Hits	396	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.119460 (rank : 247)
Query Neighborhood Hits	396	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.124724 (rank : 236)
Query Neighborhood Hits	396	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.076934 (rank : 349)
Query Neighborhood Hits	396	Target Neighborhood Hits	144	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.083521 (rank : 328)
Query Neighborhood Hits	396	Target Neighborhood Hits	179	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.073765 (rank : 355)
Query Neighborhood Hits	396	Target Neighborhood Hits	149	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.090505 (rank : 310)
Query Neighborhood Hits	396	Target Neighborhood Hits	455	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.076911 (rank : 350)
Query Neighborhood Hits	396	Target Neighborhood Hits	326	Shared Neighborhood Hits	70
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.079743 (rank : 342)
Query Neighborhood Hits	396	Target Neighborhood Hits	188	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.084200 (rank : 323)
Query Neighborhood Hits	396	Target Neighborhood Hits	174	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.116593 (rank : 255)
Query Neighborhood Hits	396	Target Neighborhood Hits	141	Shared Neighborhood Hits	53
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.120664 (rank : 243)
Query Neighborhood Hits	396	Target Neighborhood Hits	137	Shared Neighborhood Hits	54
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.113555 (rank : 264)
Query Neighborhood Hits	396	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.117674 (rank : 252)
Query Neighborhood Hits	396	Target Neighborhood Hits	180	Shared Neighborhood Hits	60
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.109157 (rank : 273)
Query Neighborhood Hits	396	Target Neighborhood Hits	170	Shared Neighborhood Hits	57
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.110537 (rank : 268)
Query Neighborhood Hits	396	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.114314 (rank : 260)
Query Neighborhood Hits	396	Target Neighborhood Hits	155	Shared Neighborhood Hits	52
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.122579 (rank : 242)
Query Neighborhood Hits	396	Target Neighborhood Hits	151	Shared Neighborhood Hits	55
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.111076 (rank : 267)
Query Neighborhood Hits	396	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.116369 (rank : 257)
Query Neighborhood Hits	396	Target Neighborhood Hits	137	Shared Neighborhood Hits	55
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.123083 (rank : 240)
Query Neighborhood Hits	396	Target Neighborhood Hits	164	Shared Neighborhood Hits	53
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.128017 (rank : 233)
Query Neighborhood Hits	396	Target Neighborhood Hits	169	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.174672 (rank : 186)
Query Neighborhood Hits	396	Target Neighborhood Hits	113	Shared Neighborhood Hits	52
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.173224 (rank : 189)
Query Neighborhood Hits	396	Target Neighborhood Hits	117	Shared Neighborhood Hits	53
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.195329 (rank : 170)
Query Neighborhood Hits	396	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.194929 (rank : 171)
Query Neighborhood Hits	396	Target Neighborhood Hits	136	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SOCS1_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.053314 (rank : 424)
Query Neighborhood Hits	396	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.054060 (rank : 418)
Query Neighborhood Hits	396	Target Neighborhood Hits	82	Shared Neighborhood Hits	28
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS2_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.079009 (rank : 344)
Query Neighborhood Hits	396	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.083015 (rank : 331)
Query Neighborhood Hits	396	Target Neighborhood Hits	94	Shared Neighborhood Hits	36
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS3_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.050017 (rank : 459)
Query Neighborhood Hits	396	Target Neighborhood Hits	77	Shared Neighborhood Hits	29
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS6_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.076116 (rank : 351)
Query Neighborhood Hits	396	Target Neighborhood Hits	126	Shared Neighborhood Hits	39
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.077766 (rank : 347)
Query Neighborhood Hits	396	Target Neighborhood Hits	146	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.081830 (rank : 334)
Query Neighborhood Hits	396	Target Neighborhood Hits	154	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOS1_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.059996 (rank : 395)
Query Neighborhood Hits	396	Target Neighborhood Hits	274	Shared Neighborhood Hits	41
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.057845 (rank : 400)
Query Neighborhood Hits	396	Target Neighborhood Hits	281	Shared Neighborhood Hits	46
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SPN90_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.196564 (rank : 169)
Query Neighborhood Hits	396	Target Neighborhood Hits	157	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.175743 (rank : 185)
Query Neighborhood Hits	396	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRRM1_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.052267 (rank : 436)
Query Neighborhood Hits	396	Target Neighborhood Hits	690	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.053953 (rank : 420)
Query Neighborhood Hits	396	Target Neighborhood Hits	966	Shared Neighborhood Hits	91
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

STYK1_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.052965 (rank : 428)
Query Neighborhood Hits	396	Target Neighborhood Hits	786	Shared Neighborhood Hits	45
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.053521 (rank : 422)
Query Neighborhood Hits	396	Target Neighborhood Hits	779	Shared Neighborhood Hits	45
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TAGAP_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.052403 (rank : 434)
Query Neighborhood Hits	396	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TARA_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.050397 (rank : 449)
Query Neighborhood Hits	396	Target Neighborhood Hits	1626	Shared Neighborhood Hits	115
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TENS4_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.064423 (rank : 387)
Query Neighborhood Hits	396	Target Neighborhood Hits	214	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.063072 (rank : 391)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.066442 (rank : 382)
Query Neighborhood Hits	396	Target Neighborhood Hits	1333	Shared Neighborhood Hits	101
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIAM1_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.156114 (rank : 207)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	41
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.158503 (rank : 205)
Query Neighborhood Hits	396	Target Neighborhood Hits	205	Shared Neighborhood Hits	35
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TNK1_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.055024 (rank : 410)
Query Neighborhood Hits	396	Target Neighborhood Hits	815	Shared Neighborhood Hits	56
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.055331 (rank : 408)
Query Neighborhood Hits	396	Target Neighborhood Hits	806	Shared Neighborhood Hits	53
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TXND2_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.050695 (rank : 445)
Query Neighborhood Hits	396	Target Neighborhood Hits	793	Shared Neighborhood Hits	75
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ZAP70_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.071690 (rank : 367)
Query Neighborhood Hits	396	Target Neighborhood Hits	893	Shared Neighborhood Hits	71
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.072554 (rank : 363)
Query Neighborhood Hits	396	Target Neighborhood Hits	905	Shared Neighborhood Hits	71
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

SRBS1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	396	Target Neighborhood Hits	396	Shared Neighborhood Hits	396
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.934573 (rank : 2)	θ value	1.01238e-168 (rank : 2)
Query Neighborhood Hits	396	Target Neighborhood Hits	409	Shared Neighborhood Hits	250
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.878071 (rank : 3)	θ value	1.04822e-48 (rank : 3)
Query Neighborhood Hits	396	Target Neighborhood Hits	270	Shared Neighborhood Hits	223
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.872547 (rank : 4)	θ value	2.3352e-48 (rank : 4)
Query Neighborhood Hits	396	Target Neighborhood Hits	286	Shared Neighborhood Hits	220
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

CD2AP_HUMAN
NC score	0.695613 (rank : 5)	θ value	1.25267e-09 (rank : 12)
Query Neighborhood Hits	396	Target Neighborhood Hits	315	Shared Neighborhood Hits	216
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_HUMAN
NC score	0.691976 (rank : 6)	θ value	1.80886e-08 (rank : 18)
Query Neighborhood Hits	396	Target Neighborhood Hits	341	Shared Neighborhood Hits	215
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CD2AP_MOUSE
NC score	0.687677 (rank : 7)	θ value	1.38499e-08 (rank : 15)
Query Neighborhood Hits	396	Target Neighborhood Hits	336	Shared Neighborhood Hits	219
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.685266 (rank : 8)	θ value	4.0297e-08 (rank : 22)
Query Neighborhood Hits	396	Target Neighborhood Hits	332	Shared Neighborhood Hits	214
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF2_HUMAN
NC score	0.668850 (rank : 9)	θ value	1.29631e-06 (rank : 41)
Query Neighborhood Hits	396	Target Neighborhood Hits	229	Shared Neighborhood Hits	179
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3G3_MOUSE
NC score	0.630796 (rank : 10)	θ value	6.87365e-08 (rank : 26)
Query Neighborhood Hits	396	Target Neighborhood Hits	236	Shared Neighborhood Hits	196
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G2_HUMAN
NC score	0.623310 (rank : 11)	θ value	1.38499e-08 (rank : 16)
Query Neighborhood Hits	396	Target Neighborhood Hits	324	Shared Neighborhood Hits	198
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
NC score	0.622634 (rank : 12)	θ value	1.80886e-08 (rank : 17)
Query Neighborhood Hits	396	Target Neighborhood Hits	222	Shared Neighborhood Hits	189
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G2_MOUSE
NC score	0.614049 (rank : 13)	θ value	4.0297e-08 (rank : 21)
Query Neighborhood Hits	396	Target Neighborhood Hits	319	Shared Neighborhood Hits	199
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G1_MOUSE
NC score	0.610332 (rank : 14)	θ value	2.36244e-08 (rank : 19)
Query Neighborhood Hits	396	Target Neighborhood Hits	291	Shared Neighborhood Hits	197
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

NCF4_MOUSE
NC score	0.607649 (rank : 15)	θ value	8.40245e-06 (rank : 52)
Query Neighborhood Hits	396	Target Neighborhood Hits	177	Shared Neighborhood Hits	150
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI2_MOUSE
NC score	0.607148 (rank : 16)	θ value	1.09739e-05 (rank : 54)
Query Neighborhood Hits	396	Target Neighborhood Hits	266	Shared Neighborhood Hits	192
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.605059 (rank : 17)	θ value	1.09739e-05 (rank : 53)
Query Neighborhood Hits	396	Target Neighborhood Hits	350	Shared Neighborhood Hits	208
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SH3G1_HUMAN
NC score	0.603128 (rank : 18)	θ value	1.17247e-07 (rank : 29)
Query Neighborhood Hits	396	Target Neighborhood Hits	307	Shared Neighborhood Hits	197
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ABI1_MOUSE
NC score	0.602309 (rank : 19)	θ value	1.99992e-07 (rank : 32)
Query Neighborhood Hits	396	Target Neighborhood Hits	246	Shared Neighborhood Hits	183
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

GRB2_HUMAN
NC score	0.595380 (rank : 20)	θ value	4.45536e-07 (rank : 33)
Query Neighborhood Hits	396	Target Neighborhood Hits	310	Shared Neighborhood Hits	195
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.593903 (rank : 21)	θ value	4.45536e-07 (rank : 34)
Query Neighborhood Hits	396	Target Neighborhood Hits	312	Shared Neighborhood Hits	195
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF4_HUMAN
NC score	0.587255 (rank : 22)	θ value	4.92598e-06 (rank : 48)
Query Neighborhood Hits	396	Target Neighborhood Hits	161	Shared Neighborhood Hits	131
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DNMBP_HUMAN
NC score	0.585615 (rank : 23)	θ value	7.84624e-12 (rank : 5)
Query Neighborhood Hits	396	Target Neighborhood Hits	413	Shared Neighborhood Hits	211
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

HCLS1_MOUSE
NC score	0.582053 (rank : 24)	θ value	0.000121331 (rank : 77)
Query Neighborhood Hits	396	Target Neighborhood Hits	329	Shared Neighborhood Hits	190
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

DNMBP_MOUSE
NC score	0.579817 (rank : 25)	θ value	2.28291e-11 (rank : 6)
Query Neighborhood Hits	396	Target Neighborhood Hits	435	Shared Neighborhood Hits	218
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ABI1_HUMAN
NC score	0.579442 (rank : 26)	θ value	9.92553e-07 (rank : 38)
Query Neighborhood Hits	396	Target Neighborhood Hits	257	Shared Neighborhood Hits	181
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SRC8_HUMAN
NC score	0.578584 (rank : 27)	θ value	0.000270298 (rank : 85)
Query Neighborhood Hits	396	Target Neighborhood Hits	269	Shared Neighborhood Hits	187
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.578197 (rank : 28)	θ value	0.000270298 (rank : 86)
Query Neighborhood Hits	396	Target Neighborhood Hits	292	Shared Neighborhood Hits	189
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

HCLS1_HUMAN
NC score	0.575459 (rank : 29)	θ value	0.00020696 (rank : 80)
Query Neighborhood Hits	396	Target Neighborhood Hits	358	Shared Neighborhood Hits	180
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GRAP_MOUSE
NC score	0.573141 (rank : 30)	θ value	8.97725e-08 (rank : 27)
Query Neighborhood Hits	396	Target Neighborhood Hits	309	Shared Neighborhood Hits	209
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.572651 (rank : 31)	θ value	5.81887e-07 (rank : 36)
Query Neighborhood Hits	396	Target Neighborhood Hits	310	Shared Neighborhood Hits	199
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.571048 (rank : 32)	θ value	4.45536e-07 (rank : 35)
Query Neighborhood Hits	396	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PPIP1_HUMAN
NC score	0.568325 (rank : 33)	θ value	9.92553e-07 (rank : 39)
Query Neighborhood Hits	396	Target Neighborhood Hits	389	Shared Neighborhood Hits	203
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRAP_HUMAN
NC score	0.565197 (rank : 34)	θ value	1.53129e-07 (rank : 31)
Query Neighborhood Hits	396	Target Neighborhood Hits	307	Shared Neighborhood Hits	202
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PPIP1_MOUSE
NC score	0.562908 (rank : 35)	θ value	3.77169e-06 (rank : 47)
Query Neighborhood Hits	396	Target Neighborhood Hits	377	Shared Neighborhood Hits	205
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ARHG7_MOUSE
NC score	0.555046 (rank : 36)	θ value	3.08544e-08 (rank : 20)
Query Neighborhood Hits	396	Target Neighborhood Hits	396	Shared Neighborhood Hits	212
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP2_MOUSE
NC score	0.552003 (rank : 37)	θ value	4.1701e-05 (rank : 70)
Query Neighborhood Hits	396	Target Neighborhood Hits	297	Shared Neighborhood Hits	196
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ABI3_HUMAN
NC score	0.548761 (rank : 38)	θ value	5.44631e-05 (rank : 72)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	155
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

LASP1_HUMAN
NC score	0.547209 (rank : 39)	θ value	5.26297e-08 (rank : 23)
Query Neighborhood Hits	396	Target Neighborhood Hits	293	Shared Neighborhood Hits	169
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.547153 (rank : 40)	θ value	5.26297e-08 (rank : 24)
Query Neighborhood Hits	396	Target Neighborhood Hits	297	Shared Neighborhood Hits	169
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

STAM1_MOUSE
NC score	0.546842 (rank : 41)	θ value	2.88788e-06 (rank : 46)
Query Neighborhood Hits	396	Target Neighborhood Hits	273	Shared Neighborhood Hits	189
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC_HUMAN
NC score	0.546468 (rank : 42)	θ value	4.92598e-06 (rank : 49)
Query Neighborhood Hits	396	Target Neighborhood Hits	276	Shared Neighborhood Hits	183
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
NC score	0.543564 (rank : 43)	θ value	1.43324e-05 (rank : 59)
Query Neighborhood Hits	396	Target Neighborhood Hits	271	Shared Neighborhood Hits	190
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI3_MOUSE
NC score	0.542909 (rank : 44)	θ value	4.1701e-05 (rank : 69)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	153
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

GRAP2_HUMAN
NC score	0.542349 (rank : 45)	θ value	7.1131e-05 (rank : 74)
Query Neighborhood Hits	396	Target Neighborhood Hits	304	Shared Neighborhood Hits	196
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRKL_HUMAN
NC score	0.537640 (rank : 46)	θ value	1.43324e-05 (rank : 57)
Query Neighborhood Hits	396	Target Neighborhood Hits	313	Shared Neighborhood Hits	192
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

STAC_MOUSE
NC score	0.533304 (rank : 47)	θ value	1.09739e-05 (rank : 56)
Query Neighborhood Hits	396	Target Neighborhood Hits	268	Shared Neighborhood Hits	179
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM2_MOUSE
NC score	0.532817 (rank : 48)	θ value	3.19293e-05 (rank : 68)
Query Neighborhood Hits	396	Target Neighborhood Hits	285	Shared Neighborhood Hits	188
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

CRKL_MOUSE
NC score	0.532223 (rank : 49)	θ value	3.19293e-05 (rank : 66)
Query Neighborhood Hits	396	Target Neighborhood Hits	307	Shared Neighborhood Hits	190
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ARHG7_HUMAN
NC score	0.531968 (rank : 50)	θ value	6.43352e-06 (rank : 50)
Query Neighborhood Hits	396	Target Neighborhood Hits	347	Shared Neighborhood Hits	199
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG6_MOUSE
NC score	0.531917 (rank : 51)	θ value	1.53129e-07 (rank : 30)
Query Neighborhood Hits	396	Target Neighborhood Hits	394	Shared Neighborhood Hits	202
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CRK_MOUSE
NC score	0.531429 (rank : 52)	θ value	2.21117e-06 (rank : 44)
Query Neighborhood Hits	396	Target Neighborhood Hits	314	Shared Neighborhood Hits	192
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAM2_HUMAN
NC score	0.526841 (rank : 53)	θ value	1.43324e-05 (rank : 60)
Query Neighborhood Hits	396	Target Neighborhood Hits	288	Shared Neighborhood Hits	188
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ARHG6_HUMAN
NC score	0.524777 (rank : 54)	θ value	1.29631e-06 (rank : 40)
Query Neighborhood Hits	396	Target Neighborhood Hits	376	Shared Neighborhood Hits	203
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CRK_HUMAN
NC score	0.523576 (rank : 55)	θ value	8.40245e-06 (rank : 51)
Query Neighborhood Hits	396	Target Neighborhood Hits	308	Shared Neighborhood Hits	192
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCF1_MOUSE
NC score	0.521918 (rank : 56)	θ value	0.00175202 (rank : 104)
Query Neighborhood Hits	396	Target Neighborhood Hits	198	Shared Neighborhood Hits	167
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NEBL_HUMAN
NC score	0.521906 (rank : 57)	θ value	9.59137e-10 (rank : 11)
Query Neighborhood Hits	396	Target Neighborhood Hits	457	Shared Neighborhood Hits	197
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NCF1_HUMAN
NC score	0.512961 (rank : 58)	θ value	0.0113563 (rank : 129)
Query Neighborhood Hits	396	Target Neighborhood Hits	198	Shared Neighborhood Hits	156
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PACN2_HUMAN
NC score	0.505180 (rank : 59)	θ value	4.1701e-05 (rank : 71)
Query Neighborhood Hits	396	Target Neighborhood Hits	339	Shared Neighborhood Hits	195
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

VAV_MOUSE
NC score	0.501133 (rank : 60)	θ value	2.21117e-06 (rank : 45)
Query Neighborhood Hits	396	Target Neighborhood Hits	430	Shared Neighborhood Hits	207
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.501106 (rank : 61)	θ value	1.69304e-06 (rank : 43)
Query Neighborhood Hits	396	Target Neighborhood Hits	452	Shared Neighborhood Hits	204
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PACN2_MOUSE
NC score	0.500454 (rank : 62)	θ value	0.00020696 (rank : 82)
Query Neighborhood Hits	396	Target Neighborhood Hits	382	Shared Neighborhood Hits	202
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

VAV2_MOUSE
NC score	0.492672 (rank : 63)	θ value	1.06045e-08 (rank : 14)
Query Neighborhood Hits	396	Target Neighborhood Hits	456	Shared Neighborhood Hits	192
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.491721 (rank : 64)	θ value	1.06045e-08 (rank : 13)
Query Neighborhood Hits	396	Target Neighborhood Hits	453	Shared Neighborhood Hits	193
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PACN1_HUMAN
NC score	0.490040 (rank : 65)	θ value	0.00665767 (rank : 119)
Query Neighborhood Hits	396	Target Neighborhood Hits	320	Shared Neighborhood Hits	188
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.489146 (rank : 66)	θ value	0.00665767 (rank : 120)
Query Neighborhood Hits	396	Target Neighborhood Hits	283	Shared Neighborhood Hits	185
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

OSTF1_HUMAN
NC score	0.476176 (rank : 67)	θ value	1.43324e-05 (rank : 58)
Query Neighborhood Hits	396	Target Neighborhood Hits	466	Shared Neighborhood Hits	201
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

VAV3_HUMAN
NC score	0.468654 (rank : 68)	θ value	5.26297e-08 (rank : 25)
Query Neighborhood Hits	396	Target Neighborhood Hits	398	Shared Neighborhood Hits	192
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PACN3_HUMAN
NC score	0.467050 (rank : 69)	θ value	0.00390308 (rank : 111)
Query Neighborhood Hits	396	Target Neighborhood Hits	385	Shared Neighborhood Hits	184
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ITSN2_HUMAN
NC score	0.465032 (rank : 70)	θ value	6.64225e-11 (rank : 7)
Query Neighborhood Hits	396	Target Neighborhood Hits	1173	Shared Neighborhood Hits	250
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PACN3_MOUSE
NC score	0.464944 (rank : 71)	θ value	0.00869519 (rank : 125)
Query Neighborhood Hits	396	Target Neighborhood Hits	380	Shared Neighborhood Hits	187
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

DBNL_HUMAN
NC score	0.464482 (rank : 72)	θ value	0.0736092 (rank : 149)
Query Neighborhood Hits	396	Target Neighborhood Hits	244	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

VAV3_MOUSE
NC score	0.462492 (rank : 73)	θ value	8.97725e-08 (rank : 28)
Query Neighborhood Hits	396	Target Neighborhood Hits	404	Shared Neighborhood Hits	188
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

OSTF1_MOUSE
NC score	0.458612 (rank : 74)	θ value	9.29e-05 (rank : 76)
Query Neighborhood Hits	396	Target Neighborhood Hits	467	Shared Neighborhood Hits	201
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DBNL_MOUSE
NC score	0.456678 (rank : 75)	θ value	0.0736092 (rank : 150)
Query Neighborhood Hits	396	Target Neighborhood Hits	306	Shared Neighborhood Hits	159
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NPHP1_MOUSE
NC score	0.455536 (rank : 76)	θ value	0.00134147 (rank : 102)
Query Neighborhood Hits	396	Target Neighborhood Hits	267	Shared Neighborhood Hits	172
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ITSN2_MOUSE
NC score	0.443245 (rank : 77)	θ value	2.52405e-10 (rank : 9)
Query Neighborhood Hits	396	Target Neighborhood Hits	1371	Shared Neighborhood Hits	250
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NEBU_HUMAN
NC score	0.441708 (rank : 78)	θ value	7.59969e-07 (rank : 37)
Query Neighborhood Hits	396	Target Neighborhood Hits	420	Shared Neighborhood Hits	182
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ITSN1_MOUSE
NC score	0.441262 (rank : 79)	θ value	3.29651e-10 (rank : 10)
Query Neighborhood Hits	396	Target Neighborhood Hits	1669	Shared Neighborhood Hits	284
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.440658 (rank : 80)	θ value	2.52405e-10 (rank : 8)
Query Neighborhood Hits	396	Target Neighborhood Hits	1757	Shared Neighborhood Hits	286
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

STAC3_MOUSE
NC score	0.429531 (rank : 81)	θ value	0.813845 (rank : 232)
Query Neighborhood Hits	396	Target Neighborhood Hits	232	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.426201 (rank : 82)	θ value	1.38821 (rank : 255)
Query Neighborhood Hits	396	Target Neighborhood Hits	228	Shared Neighborhood Hits	147
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NPHP1_HUMAN
NC score	0.406899 (rank : 83)	θ value	0.0330416 (rank : 142)
Query Neighborhood Hits	396	Target Neighborhood Hits	288	Shared Neighborhood Hits	169
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

EFS_MOUSE
NC score	0.387267 (rank : 84)	θ value	0.0736092 (rank : 151)
Query Neighborhood Hits	396	Target Neighborhood Hits	389	Shared Neighborhood Hits	167
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

AHI1_MOUSE
NC score	0.386898 (rank : 85)	θ value	0.00228821 (rank : 105)
Query Neighborhood Hits	396	Target Neighborhood Hits	496	Shared Neighborhood Hits	201
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

SNX18_MOUSE
NC score	0.386552 (rank : 86)	θ value	0.00665767 (rank : 122)
Query Neighborhood Hits	396	Target Neighborhood Hits	198	Shared Neighborhood Hits	133
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CT032_HUMAN
NC score	0.385032 (rank : 87)	θ value	0.62314 (rank : 212)
Query Neighborhood Hits	396	Target Neighborhood Hits	235	Shared Neighborhood Hits	142
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

AHI1_HUMAN
NC score	0.382511 (rank : 88)	θ value	0.0113563 (rank : 127)
Query Neighborhood Hits	396	Target Neighborhood Hits	537	Shared Neighborhood Hits	197
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

PLCG1_MOUSE
NC score	0.381835 (rank : 89)	θ value	0.0113563 (rank : 130)
Query Neighborhood Hits	396	Target Neighborhood Hits	314	Shared Neighborhood Hits	166
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

EFS_HUMAN
NC score	0.381402 (rank : 90)	θ value	0.0330416 (rank : 140)
Query Neighborhood Hits	396	Target Neighborhood Hits	348	Shared Neighborhood Hits	160
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SNX18_HUMAN
NC score	0.377323 (rank : 91)	θ value	0.0252991 (rank : 139)
Query Neighborhood Hits	396	Target Neighborhood Hits	207	Shared Neighborhood Hits	138
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

BCAR1_MOUSE
NC score	0.368247 (rank : 92)	θ value	0.0736092 (rank : 148)
Query Neighborhood Hits	396	Target Neighborhood Hits	438	Shared Neighborhood Hits	176
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ARHG4_HUMAN
NC score	0.365213 (rank : 93)	θ value	0.125558 (rank : 162)
Query Neighborhood Hits	396	Target Neighborhood Hits	242	Shared Neighborhood Hits	161
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RHG04_HUMAN
NC score	0.362506 (rank : 94)	θ value	3.19293e-05 (rank : 67)
Query Neighborhood Hits	396	Target Neighborhood Hits	307	Shared Neighborhood Hits	166
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PLCG1_HUMAN
NC score	0.362105 (rank : 95)	θ value	0.0563607 (rank : 146)
Query Neighborhood Hits	396	Target Neighborhood Hits	293	Shared Neighborhood Hits	158
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
NC score	0.361429 (rank : 96)	θ value	0.163984 (rank : 169)
Query Neighborhood Hits	396	Target Neighborhood Hits	280	Shared Neighborhood Hits	156
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

BCAR1_HUMAN
NC score	0.360721 (rank : 97)	θ value	0.0148317 (rank : 132)
Query Neighborhood Hits	396	Target Neighborhood Hits	554	Shared Neighborhood Hits	176
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

STS2_HUMAN
NC score	0.356008 (rank : 98)	θ value	0.00020696 (rank : 83)
Query Neighborhood Hits	396	Target Neighborhood Hits	108	Shared Neighborhood Hits	95
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SRGP2_MOUSE
NC score	0.345879 (rank : 99)	θ value	2.44474e-05 (rank : 64)
Query Neighborhood Hits	396	Target Neighborhood Hits	324	Shared Neighborhood Hits	162
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ARHG9_HUMAN
NC score	0.343783 (rank : 100)	θ value	0.62314 (rank : 207)
Query Neighborhood Hits	396	Target Neighborhood Hits	235	Shared Neighborhood Hits	155
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

SRGP2_HUMAN
NC score	0.343745 (rank : 101)	θ value	1.87187e-05 (rank : 61)
Query Neighborhood Hits	396	Target Neighborhood Hits	331	Shared Neighborhood Hits	161
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ARHG9_MOUSE
NC score	0.343431 (rank : 102)	θ value	0.62314 (rank : 208)
Query Neighborhood Hits	396	Target Neighborhood Hits	234	Shared Neighborhood Hits	154
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CASL_MOUSE
NC score	0.340376 (rank : 103)	θ value	0.0961366 (rank : 159)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	150
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

SHLB1_MOUSE
NC score	0.339520 (rank : 104)	θ value	0.00509761 (rank : 114)
Query Neighborhood Hits	396	Target Neighborhood Hits	101	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

CASL_HUMAN
NC score	0.336062 (rank : 105)	θ value	0.125558 (rank : 163)
Query Neighborhood Hits	396	Target Neighborhood Hits	259	Shared Neighborhood Hits	152
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

SHLB1_HUMAN
NC score	0.331809 (rank : 106)	θ value	0.0113563 (rank : 131)
Query Neighborhood Hits	396	Target Neighborhood Hits	96	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

FNBP2_HUMAN
NC score	0.328450 (rank : 107)	θ value	1.09739e-05 (rank : 55)
Query Neighborhood Hits	396	Target Neighborhood Hits	432	Shared Neighborhood Hits	162
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RIMB2_MOUSE
NC score	0.328376 (rank : 108)	θ value	0.0563607 (rank : 147)
Query Neighborhood Hits	396	Target Neighborhood Hits	246	Shared Neighborhood Hits	116
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SRGP1_HUMAN
NC score	0.327533 (rank : 109)	θ value	2.44474e-05 (rank : 63)
Query Neighborhood Hits	396	Target Neighborhood Hits	390	Shared Neighborhood Hits	154
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RIMB2_HUMAN
NC score	0.317486 (rank : 110)	θ value	1.81305 (rank : 269)
Query Neighborhood Hits	396	Target Neighborhood Hits	263	Shared Neighborhood Hits	128
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PEX13_MOUSE
NC score	0.316064 (rank : 111)	θ value	6.88961 (rank : 363)
Query Neighborhood Hits	396	Target Neighborhood Hits	126	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

STS1_HUMAN
NC score	0.314909 (rank : 112)	θ value	1.87187e-05 (rank : 62)
Query Neighborhood Hits	396	Target Neighborhood Hits	106	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.313292 (rank : 113)	θ value	2.44474e-05 (rank : 65)
Query Neighborhood Hits	396	Target Neighborhood Hits	104	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SHLB2_MOUSE
NC score	0.312094 (rank : 114)	θ value	0.00509761 (rank : 116)
Query Neighborhood Hits	396	Target Neighborhood Hits	88	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

PEX13_HUMAN
NC score	0.310667 (rank : 115)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	396	Target Neighborhood Hits	128	Shared Neighborhood Hits	113
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SHLB2_HUMAN
NC score	0.310128 (rank : 116)	θ value	0.00509761 (rank : 115)
Query Neighborhood Hits	396	Target Neighborhood Hits	86	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ARHG5_HUMAN
NC score	0.295073 (rank : 117)	θ value	0.0113563 (rank : 128)
Query Neighborhood Hits	396	Target Neighborhood Hits	172	Shared Neighborhood Hits	105
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

RUSC1_HUMAN
NC score	0.293665 (rank : 118)	θ value	1.38821 (rank : 253)
Query Neighborhood Hits	396	Target Neighborhood Hits	226	Shared Neighborhood Hits	139
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ARHG4_MOUSE
NC score	0.292476 (rank : 119)	θ value	8.99809 (rank : 372)
Query Neighborhood Hits	396	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RHG26_HUMAN
NC score	0.285414 (rank : 120)	θ value	0.0736092 (rank : 154)
Query Neighborhood Hits	396	Target Neighborhood Hits	281	Shared Neighborhood Hits	148
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ES8L3_MOUSE
NC score	0.282911 (rank : 121)	θ value	1.06291 (rank : 236)
Query Neighborhood Hits	396	Target Neighborhood Hits	168	Shared Neighborhood Hits	141
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NGEF_MOUSE
NC score	0.278456 (rank : 122)	θ value	0.000270298 (rank : 84)
Query Neighborhood Hits	396	Target Neighborhood Hits	228	Shared Neighborhood Hits	107
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
NC score	0.275835 (rank : 123)	θ value	0.00020696 (rank : 81)
Query Neighborhood Hits	396	Target Neighborhood Hits	166	Shared Neighborhood Hits	90
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ANM2_HUMAN
NC score	0.274552 (rank : 124)	θ value	0.47712 (rank : 193)
Query Neighborhood Hits	396	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

NOXO1_MOUSE
NC score	0.273590 (rank : 125)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	396	Target Neighborhood Hits	114	Shared Neighborhood Hits	102
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SNX9_HUMAN
NC score	0.273166 (rank : 126)	θ value	0.163984 (rank : 170)
Query Neighborhood Hits	396	Target Neighborhood Hits	148	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

RUSC1_MOUSE
NC score	0.267235 (rank : 127)	θ value	4.03905 (rank : 306)
Query Neighborhood Hits	396	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ES8L3_HUMAN
NC score	0.267119 (rank : 128)	θ value	0.279714 (rank : 181)
Query Neighborhood Hits	396	Target Neighborhood Hits	206	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SPTA2_HUMAN
NC score	0.265131 (rank : 129)	θ value	1.69304e-06 (rank : 42)
Query Neighborhood Hits	396	Target Neighborhood Hits	888	Shared Neighborhood Hits	197
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

P85A_MOUSE
NC score	0.264077 (rank : 130)	θ value	0.00869519 (rank : 124)
Query Neighborhood Hits	396	Target Neighborhood Hits	435	Shared Neighborhood Hits	130
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ANM2_MOUSE
NC score	0.260755 (rank : 131)	θ value	1.06291 (rank : 233)
Query Neighborhood Hits	396	Target Neighborhood Hits	175	Shared Neighborhood Hits	141
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

IASPP_HUMAN
NC score	0.260480 (rank : 132)	θ value	1.38821 (rank : 248)
Query Neighborhood Hits	396	Target Neighborhood Hits	688	Shared Neighborhood Hits	178
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DDEF1_MOUSE
NC score	0.257600 (rank : 133)	θ value	0.0148317 (rank : 133)
Query Neighborhood Hits	396	Target Neighborhood Hits	592	Shared Neighborhood Hits	166
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MYO1F_HUMAN
NC score	0.253260 (rank : 134)	θ value	0.000461057 (rank : 90)
Query Neighborhood Hits	396	Target Neighborhood Hits	275	Shared Neighborhood Hits	194
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.251787 (rank : 135)	θ value	0.00035302 (rank : 87)
Query Neighborhood Hits	396	Target Neighborhood Hits	262	Shared Neighborhood Hits	193
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

P85A_HUMAN
NC score	0.250003 (rank : 136)	θ value	0.0252991 (rank : 138)
Query Neighborhood Hits	396	Target Neighborhood Hits	479	Shared Neighborhood Hits	127
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNX9_MOUSE
NC score	0.247484 (rank : 137)	θ value	0.21417 (rank : 178)
Query Neighborhood Hits	396	Target Neighborhood Hits	141	Shared Neighborhood Hits	93
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPTA1_MOUSE
NC score	0.247190 (rank : 138)	θ value	0.00228821 (rank : 107)
Query Neighborhood Hits	396	Target Neighborhood Hits	675	Shared Neighborhood Hits	174
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

DDEF2_MOUSE
NC score	0.245952 (rank : 139)	θ value	0.00390308 (rank : 109)
Query Neighborhood Hits	396	Target Neighborhood Hits	625	Shared Neighborhood Hits	177
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

MYO1E_HUMAN
NC score	0.245528 (rank : 140)	θ value	0.000121331 (rank : 78)
Query Neighborhood Hits	396	Target Neighborhood Hits	293	Shared Neighborhood Hits	196
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

P85B_HUMAN
NC score	0.243150 (rank : 141)	θ value	0.000158464 (rank : 79)
Query Neighborhood Hits	396	Target Neighborhood Hits	543	Shared Neighborhood Hits	109
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SPTA1_HUMAN
NC score	0.242800 (rank : 142)	θ value	0.000786445 (rank : 96)
Query Neighborhood Hits	396	Target Neighborhood Hits	748	Shared Neighborhood Hits	184
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

JIP2_MOUSE
NC score	0.241616 (rank : 143)	θ value	0.000461057 (rank : 89)
Query Neighborhood Hits	396	Target Neighborhood Hits	144	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

IASPP_MOUSE
NC score	0.241487 (rank : 144)	θ value	0.813845 (rank : 228)
Query Neighborhood Hits	396	Target Neighborhood Hits	1024	Shared Neighborhood Hits	198
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

JIP2_HUMAN
NC score	0.239997 (rank : 145)	θ value	0.000461057 (rank : 88)
Query Neighborhood Hits	396	Target Neighborhood Hits	288	Shared Neighborhood Hits	81
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ASPP1_MOUSE
NC score	0.239119 (rank : 146)	θ value	0.21417 (rank : 173)
Query Neighborhood Hits	396	Target Neighborhood Hits	1244	Shared Neighborhood Hits	204
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_HUMAN
NC score	0.238090 (rank : 147)	θ value	0.62314 (rank : 210)
Query Neighborhood Hits	396	Target Neighborhood Hits	956	Shared Neighborhood Hits	191
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

P85B_MOUSE
NC score	0.236505 (rank : 148)	θ value	0.000786445 (rank : 95)
Query Neighborhood Hits	396	Target Neighborhood Hits	519	Shared Neighborhood Hits	105
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DDEF2_HUMAN
NC score	0.235263 (rank : 149)	θ value	0.21417 (rank : 175)
Query Neighborhood Hits	396	Target Neighborhood Hits	599	Shared Neighborhood Hits	173
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ARHGG_MOUSE
NC score	0.228025 (rank : 150)	θ value	0.62314 (rank : 209)
Query Neighborhood Hits	396	Target Neighborhood Hits	152	Shared Neighborhood Hits	74
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

TCGAP_MOUSE
NC score	0.222496 (rank : 151)	θ value	1.38821 (rank : 257)
Query Neighborhood Hits	396	Target Neighborhood Hits	409	Shared Neighborhood Hits	148
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BIN1_MOUSE
NC score	0.219542 (rank : 152)	θ value	0.0193708 (rank : 136)
Query Neighborhood Hits	396	Target Neighborhood Hits	283	Shared Neighborhood Hits	107
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

JIP1_MOUSE
NC score	0.218731 (rank : 153)	θ value	0.00665767 (rank : 118)
Query Neighborhood Hits	396	Target Neighborhood Hits	259	Shared Neighborhood Hits	78
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_HUMAN
NC score	0.216395 (rank : 154)	θ value	0.00665767 (rank : 117)
Query Neighborhood Hits	396	Target Neighborhood Hits	271	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

BIN1_HUMAN
NC score	0.216314 (rank : 155)	θ value	0.0431538 (rank : 143)
Query Neighborhood Hits	396	Target Neighborhood Hits	335	Shared Neighborhood Hits	104
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

EPS8_HUMAN
NC score	0.215443 (rank : 156)	θ value	0.125558 (rank : 166)
Query Neighborhood Hits	396	Target Neighborhood Hits	151	Shared Neighborhood Hits	108
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

DOCK1_HUMAN
NC score	0.214738 (rank : 157)	θ value	0.0148317 (rank : 134)
Query Neighborhood Hits	396	Target Neighborhood Hits	191	Shared Neighborhood Hits	124
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

AMPH_HUMAN
NC score	0.212510 (rank : 158)	θ value	2.36792 (rank : 272)
Query Neighborhood Hits	396	Target Neighborhood Hits	455	Shared Neighborhood Hits	113
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

EPS8_MOUSE
NC score	0.209829 (rank : 159)	θ value	1.38821 (rank : 246)
Query Neighborhood Hits	396	Target Neighborhood Hits	157	Shared Neighborhood Hits	120
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ARHGG_HUMAN
NC score	0.206125 (rank : 160)	θ value	0.47712 (rank : 194)
Query Neighborhood Hits	396	Target Neighborhood Hits	129	Shared Neighborhood Hits	59
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP2_HUMAN
NC score	0.203485 (rank : 161)	θ value	0.21417 (rank : 174)
Query Neighborhood Hits	396	Target Neighborhood Hits	1156	Shared Neighborhood Hits	185
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

AMPH_MOUSE
NC score	0.203434 (rank : 162)	θ value	0.0961366 (rank : 156)
Query Neighborhood Hits	396	Target Neighborhood Hits	291	Shared Neighborhood Hits	100
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ES8L2_MOUSE
NC score	0.202810 (rank : 163)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	396	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

TCGAP_HUMAN
NC score	0.201679 (rank : 164)	θ value	1.38821 (rank : 256)
Query Neighborhood Hits	396	Target Neighborhood Hits	872	Shared Neighborhood Hits	163
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SHAN2_MOUSE
NC score	0.201640 (rank : 165)	θ value	3.0926 (rank : 298)
Query Neighborhood Hits	396	Target Neighborhood Hits	446	Shared Neighborhood Hits	126
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

RIMB1_HUMAN
NC score	0.201080 (rank : 166)	θ value	0.21417 (rank : 177)
Query Neighborhood Hits	396	Target Neighborhood Hits	1479	Shared Neighborhood Hits	196
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ES8L2_HUMAN
NC score	0.200954 (rank : 167)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	396	Target Neighborhood Hits	193	Shared Neighborhood Hits	125
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

NOXO1_HUMAN
NC score	0.199316 (rank : 168)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	396	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SPN90_HUMAN
NC score	0.196564 (rank : 169)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	396	Target Neighborhood Hits	157	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SLAP2_HUMAN
NC score	0.195329 (rank : 170)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	396	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
NC score	0.194929 (rank : 171)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	396	Target Neighborhood Hits	136	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

RIMB1_MOUSE
NC score	0.194062 (rank : 172)	θ value	0.00390308 (rank : 112)
Query Neighborhood Hits	396	Target Neighborhood Hits	1376	Shared Neighborhood Hits	200
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

FYN_MOUSE
NC score	0.184167 (rank : 173)	θ value	0.00175202 (rank : 103)
Query Neighborhood Hits	396	Target Neighborhood Hits	1073	Shared Neighborhood Hits	194
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ES8L1_MOUSE
NC score	0.183265 (rank : 174)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	396	Target Neighborhood Hits	143	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SLY_MOUSE
NC score	0.183152 (rank : 175)	θ value	2.36792 (rank : 283)
Query Neighborhood Hits	396	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

FGR_HUMAN
NC score	0.181514 (rank : 176)	θ value	0.0148317 (rank : 135)
Query Neighborhood Hits	396	Target Neighborhood Hits	1067	Shared Neighborhood Hits	191
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_MOUSE
NC score	0.181219 (rank : 177)	θ value	0.00102713 (rank : 100)
Query Neighborhood Hits	396	Target Neighborhood Hits	1052	Shared Neighborhood Hits	192
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_HUMAN
NC score	0.180944 (rank : 178)	θ value	0.00228821 (rank : 106)
Query Neighborhood Hits	396	Target Neighborhood Hits	1078	Shared Neighborhood Hits	194
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SRC_HUMAN
NC score	0.179744 (rank : 179)	θ value	0.000602161 (rank : 94)
Query Neighborhood Hits	396	Target Neighborhood Hits	1058	Shared Neighborhood Hits	192
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

YES_HUMAN
NC score	0.179605 (rank : 180)	θ value	0.00102713 (rank : 99)
Query Neighborhood Hits	396	Target Neighborhood Hits	1059	Shared Neighborhood Hits	192
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BAIP2_MOUSE
NC score	0.179380 (rank : 181)	θ value	0.0961366 (rank : 158)
Query Neighborhood Hits	396	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

ES8L1_HUMAN
NC score	0.178649 (rank : 182)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	396	Target Neighborhood Hits	162	Shared Neighborhood Hits	104
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

BAIP2_HUMAN
NC score	0.178405 (rank : 183)	θ value	0.0961366 (rank : 157)
Query Neighborhood Hits	396	Target Neighborhood Hits	192	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

M3KL4_HUMAN
NC score	0.178149 (rank : 184)	θ value	5.44631e-05 (rank : 73)
Query Neighborhood Hits	396	Target Neighborhood Hits	1087	Shared Neighborhood Hits	191
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SPN90_MOUSE
NC score	0.175743 (rank : 185)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	396	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SLAP1_HUMAN
NC score	0.174672 (rank : 186)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	396	Target Neighborhood Hits	113	Shared Neighborhood Hits	52
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

PKHG1_HUMAN
NC score	0.174224 (rank : 187)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	396	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FGR_MOUSE
NC score	0.173689 (rank : 188)	θ value	0.0736092 (rank : 152)
Query Neighborhood Hits	396	Target Neighborhood Hits	1069	Shared Neighborhood Hits	191
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLAP1_MOUSE
NC score	0.173224 (rank : 189)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	396	Target Neighborhood Hits	117	Shared Neighborhood Hits	53
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

P55G_HUMAN
NC score	0.171008 (rank : 190)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	396	Target Neighborhood Hits	451	Shared Neighborhood Hits	76
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
NC score	0.170487 (rank : 191)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	396	Target Neighborhood Hits	401	Shared Neighborhood Hits	73
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

BI2L1_HUMAN
NC score	0.167556 (rank : 192)	θ value	5.27518 (rank : 319)
Query Neighborhood Hits	396	Target Neighborhood Hits	156	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CIP4_HUMAN
NC score	0.164869 (rank : 193)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	396	Target Neighborhood Hits	374	Shared Neighborhood Hits	91
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

BI2L1_MOUSE
NC score	0.164687 (rank : 194)	θ value	1.38821 (rank : 243)
Query Neighborhood Hits	396	Target Neighborhood Hits	197	Shared Neighborhood Hits	74
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

M3K11_HUMAN
NC score	0.164167 (rank : 195)	θ value	0.000602161 (rank : 93)
Query Neighborhood Hits	396	Target Neighborhood Hits	1136	Shared Neighborhood Hits	201
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SLY_HUMAN
NC score	0.163843 (rank : 196)	θ value	1.38821 (rank : 254)
Query Neighborhood Hits	396	Target Neighborhood Hits	81	Shared Neighborhood Hits	56
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

RASA1_HUMAN
NC score	0.163047 (rank : 197)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	396	Target Neighborhood Hits	258	Shared Neighborhood Hits	76
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

ARHG3_HUMAN
NC score	0.162809 (rank : 198)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	396	Target Neighborhood Hits	82	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.162676 (rank : 199)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	396	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

SHAN1_HUMAN
NC score	0.162200 (rank : 200)	θ value	1.81305 (rank : 271)
Query Neighborhood Hits	396	Target Neighborhood Hits	1041	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

BTK_HUMAN
NC score	0.160203 (rank : 201)	θ value	0.00509761 (rank : 113)
Query Neighborhood Hits	396	Target Neighborhood Hits	1026	Shared Neighborhood Hits	189
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

PREX1_HUMAN
NC score	0.160149 (rank : 202)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	396	Target Neighborhood Hits	177	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

M3K9_HUMAN
NC score	0.160038 (rank : 203)	θ value	7.1131e-05 (rank : 75)
Query Neighborhood Hits	396	Target Neighborhood Hits	1123	Shared Neighborhood Hits	196
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ARHG8_MOUSE
NC score	0.159159 (rank : 204)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	396	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

TIAM1_MOUSE
NC score	0.158503 (rank : 205)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	396	Target Neighborhood Hits	205	Shared Neighborhood Hits	35
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

MCF2L_MOUSE
NC score	0.156406 (rank : 206)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	396	Target Neighborhood Hits	255	Shared Neighborhood Hits	56
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

TIAM1_HUMAN
NC score	0.156114 (rank : 207)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	41
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SRC_MOUSE
NC score	0.155479 (rank : 208)	θ value	0.163984 (rank : 171)
Query Neighborhood Hits	396	Target Neighborhood Hits	1033	Shared Neighborhood Hits	171
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HCK_MOUSE
NC score	0.154561 (rank : 209)	θ value	0.21417 (rank : 176)
Query Neighborhood Hits	396	Target Neighborhood Hits	1029	Shared Neighborhood Hits	181
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

BTK_MOUSE
NC score	0.153969 (rank : 210)	θ value	0.0252991 (rank : 137)
Query Neighborhood Hits	396	Target Neighborhood Hits	1017	Shared Neighborhood Hits	178
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

HCK_HUMAN
NC score	0.152669 (rank : 211)	θ value	0.62314 (rank : 213)
Query Neighborhood Hits	396	Target Neighborhood Hits	1035	Shared Neighborhood Hits	180
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FUT8_HUMAN
NC score	0.150690 (rank : 212)	θ value	0.0961366 (rank : 160)
Query Neighborhood Hits	396	Target Neighborhood Hits	67	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

ARHG8_HUMAN
NC score	0.149408 (rank : 213)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	396	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

M3K10_HUMAN
NC score	0.145804 (rank : 214)	θ value	0.00134147 (rank : 101)
Query Neighborhood Hits	396	Target Neighborhood Hits	1071	Shared Neighborhood Hits	179
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

DAPP1_MOUSE
NC score	0.145082 (rank : 215)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

FUT8_MOUSE
NC score	0.143523 (rank : 216)	θ value	0.279714 (rank : 182)
Query Neighborhood Hits	396	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FRK_HUMAN
NC score	0.143484 (rank : 217)	θ value	0.365318 (rank : 187)
Query Neighborhood Hits	396	Target Neighborhood Hits	1058	Shared Neighborhood Hits	184
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

DAPP1_HUMAN
NC score	0.142359 (rank : 218)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

LYN_MOUSE
NC score	0.141830 (rank : 219)	θ value	0.279714 (rank : 183)
Query Neighborhood Hits	396	Target Neighborhood Hits	1023	Shared Neighborhood Hits	167
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.141754 (rank : 220)	θ value	0.47712 (rank : 198)
Query Neighborhood Hits	396	Target Neighborhood Hits	1022	Shared Neighborhood Hits	168
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CSK_MOUSE
NC score	0.140650 (rank : 221)	θ value	0.000602161 (rank : 92)
Query Neighborhood Hits	396	Target Neighborhood Hits	1009	Shared Neighborhood Hits	147
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.140522 (rank : 222)	θ value	0.000602161 (rank : 91)
Query Neighborhood Hits	396	Target Neighborhood Hits	1009	Shared Neighborhood Hits	147
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

BLK_HUMAN
NC score	0.136235 (rank : 223)	θ value	0.279714 (rank : 179)
Query Neighborhood Hits	396	Target Neighborhood Hits	994	Shared Neighborhood Hits	151
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ECT2_MOUSE
NC score	0.136171 (rank : 224)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	396	Target Neighborhood Hits	98	Shared Neighborhood Hits	29
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

TXK_MOUSE
NC score	0.135781 (rank : 225)	θ value	0.00102713 (rank : 98)
Query Neighborhood Hits	396	Target Neighborhood Hits	980	Shared Neighborhood Hits	152
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

BLK_MOUSE
NC score	0.133946 (rank : 226)	θ value	0.365318 (rank : 186)
Query Neighborhood Hits	396	Target Neighborhood Hits	992	Shared Neighborhood Hits	140
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ARHGF_HUMAN
NC score	0.133804 (rank : 227)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	396	Target Neighborhood Hits	214	Shared Neighborhood Hits	48
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

MCF2_HUMAN
NC score	0.133056 (rank : 228)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	396	Target Neighborhood Hits	166	Shared Neighborhood Hits	34
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ECT2_HUMAN
NC score	0.132091 (rank : 229)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	396	Target Neighborhood Hits	98	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_MOUSE
NC score	0.130602 (rank : 230)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	396	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.128520 (rank : 231)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	396	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG1_HUMAN
NC score	0.128512 (rank : 232)	θ value	5.27518 (rank : 317)
Query Neighborhood Hits	396	Target Neighborhood Hits	176	Shared Neighborhood Hits	32
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

SHE_MOUSE
NC score	0.128017 (rank : 233)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	396	Target Neighborhood Hits	169	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

TXK_HUMAN
NC score	0.125741 (rank : 234)	θ value	0.0431538 (rank : 144)
Query Neighborhood Hits	396	Target Neighborhood Hits	971	Shared Neighborhood Hits	137
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

EM55_HUMAN
NC score	0.125211 (rank : 235)	θ value	1.06291 (rank : 235)
Query Neighborhood Hits	396	Target Neighborhood Hits	228	Shared Neighborhood Hits	97
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SH21B_MOUSE
NC score	0.124724 (rank : 236)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	396	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

LCK_HUMAN
NC score	0.124576 (rank : 237)	θ value	1.06291 (rank : 238)
Query Neighborhood Hits	396	Target Neighborhood Hits	987	Shared Neighborhood Hits	129
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

TEC_HUMAN
NC score	0.123601 (rank : 238)	θ value	8.99809 (rank : 393)
Query Neighborhood Hits	396	Target Neighborhood Hits	1006	Shared Neighborhood Hits	151
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LCK_MOUSE
NC score	0.123589 (rank : 239)	θ value	0.62314 (rank : 215)
Query Neighborhood Hits	396	Target Neighborhood Hits	981	Shared Neighborhood Hits	128
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SHE_HUMAN
NC score	0.123083 (rank : 240)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	396	Target Neighborhood Hits	164	Shared Neighborhood Hits	53
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PTK6_MOUSE
NC score	0.122703 (rank : 241)	θ value	5.27518 (rank : 335)
Query Neighborhood Hits	396	Target Neighborhood Hits	1026	Shared Neighborhood Hits	161
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SHC3_MOUSE
NC score	0.122579 (rank : 242)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	396	Target Neighborhood Hits	151	Shared Neighborhood Hits	55
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHB_MOUSE
NC score	0.120664 (rank : 243)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	396	Target Neighborhood Hits	137	Shared Neighborhood Hits	54
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PTK6_HUMAN
NC score	0.120087 (rank : 244)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	396	Target Neighborhood Hits	1020	Shared Neighborhood Hits	163
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TEC_MOUSE
NC score	0.120013 (rank : 245)	θ value	5.27518 (rank : 340)
Query Neighborhood Hits	396	Target Neighborhood Hits	1006	Shared Neighborhood Hits	149
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

EM55_MOUSE
NC score	0.119464 (rank : 246)	θ value	1.81305 (rank : 260)
Query Neighborhood Hits	396	Target Neighborhood Hits	221	Shared Neighborhood Hits	93
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SH21B_HUMAN
NC score	0.119460 (rank : 247)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	396	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ABL1_HUMAN
NC score	0.119254 (rank : 248)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	396	Target Neighborhood Hits	1220	Shared Neighborhood Hits	158
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.118877 (rank : 249)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	396	Target Neighborhood Hits	1178	Shared Neighborhood Hits	158
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BCR_HUMAN
NC score	0.118113 (rank : 250)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	396	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHGB_HUMAN
NC score	0.117901 (rank : 251)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	396	Target Neighborhood Hits	375	Shared Neighborhood Hits	47
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SHC1_MOUSE
NC score	0.117674 (rank : 252)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	396	Target Neighborhood Hits	180	Shared Neighborhood Hits	60
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ARHGC_MOUSE
NC score	0.117232 (rank : 253)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	396	Target Neighborhood Hits	344	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.116863 (rank : 254)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	396	Target Neighborhood Hits	351	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SHB_HUMAN
NC score	0.116593 (rank : 255)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	396	Target Neighborhood Hits	141	Shared Neighborhood Hits	53
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

ARHG1_MOUSE
NC score	0.116402 (rank : 256)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	396	Target Neighborhood Hits	266	Shared Neighborhood Hits	32
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

SHD_MOUSE
NC score	0.116369 (rank : 257)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	396	Target Neighborhood Hits	137	Shared Neighborhood Hits	55
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

APS_HUMAN
NC score	0.115767 (rank : 258)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	396	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

RHG09_HUMAN
NC score	0.114979 (rank : 259)	θ value	0.365318 (rank : 189)
Query Neighborhood Hits	396	Target Neighborhood Hits	186	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

SHC3_HUMAN
NC score	0.114314 (rank : 260)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	396	Target Neighborhood Hits	155	Shared Neighborhood Hits	52
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

ABL2_HUMAN
NC score	0.114205 (rank : 261)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	396	Target Neighborhood Hits	1045	Shared Neighborhood Hits	135
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

SASH1_HUMAN
NC score	0.114180 (rank : 262)	θ value	5.27518 (rank : 336)
Query Neighborhood Hits	396	Target Neighborhood Hits	292	Shared Neighborhood Hits	73
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

GRB14_MOUSE
NC score	0.113956 (rank : 263)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	396	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHC1_HUMAN
NC score	0.113555 (rank : 264)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	396	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ITK_HUMAN
NC score	0.111387 (rank : 265)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	396	Target Neighborhood Hits	1016	Shared Neighborhood Hits	143
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

HAPIP_HUMAN
NC score	0.111209 (rank : 266)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	396	Target Neighborhood Hits	350	Shared Neighborhood Hits	39
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

SHD_HUMAN
NC score	0.111076 (rank : 267)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	396	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC2_MOUSE
NC score	0.110537 (rank : 268)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	396	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

GRB14_HUMAN
NC score	0.110399 (rank : 269)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	396	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SASH1_MOUSE
NC score	0.109710 (rank : 270)	θ value	5.27518 (rank : 337)
Query Neighborhood Hits	396	Target Neighborhood Hits	263	Shared Neighborhood Hits	69
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CHIN_MOUSE
NC score	0.109587 (rank : 271)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	396	Target Neighborhood Hits	229	Shared Neighborhood Hits	61
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

FGD3_MOUSE
NC score	0.109443 (rank : 272)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	396	Target Neighborhood Hits	257	Shared Neighborhood Hits	35
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

SHC2_HUMAN
NC score	0.109157 (rank : 273)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	396	Target Neighborhood Hits	170	Shared Neighborhood Hits	57
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

RUSC2_HUMAN
NC score	0.108722 (rank : 274)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	396	Target Neighborhood Hits	205	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

GNRP_MOUSE
NC score	0.108715 (rank : 275)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	396	Target Neighborhood Hits	191	Shared Neighborhood Hits	33
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SAMN1_HUMAN
NC score	0.108713 (rank : 276)	θ value	2.36792 (rank : 282)
Query Neighborhood Hits	396	Target Neighborhood Hits	74	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

RGNEF_MOUSE
NC score	0.108617 (rank : 277)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	396	Target Neighborhood Hits	641	Shared Neighborhood Hits	64
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ABR_HUMAN
NC score	0.107541 (rank : 278)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	396	Target Neighborhood Hits	166	Shared Neighborhood Hits	43
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

HSH2D_HUMAN
NC score	0.107101 (rank : 279)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	396	Target Neighborhood Hits	159	Shared Neighborhood Hits	47
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

CHIN_HUMAN
NC score	0.107013 (rank : 280)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.106841 (rank : 281)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	396	Target Neighborhood Hits	220	Shared Neighborhood Hits	55
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

LNK_MOUSE
NC score	0.106090 (rank : 282)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	396	Target Neighborhood Hits	132	Shared Neighborhood Hits	44
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MPP6_HUMAN
NC score	0.105724 (rank : 283)	θ value	5.27518 (rank : 329)
Query Neighborhood Hits	396	Target Neighborhood Hits	180	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

RHG12_MOUSE
NC score	0.105602 (rank : 284)	θ value	1.81305 (rank : 268)
Query Neighborhood Hits	396	Target Neighborhood Hits	204	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

LNK_HUMAN
NC score	0.105267 (rank : 285)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	396	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

FGD4_MOUSE
NC score	0.105118 (rank : 286)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
NC score	0.104654 (rank : 287)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	396	Target Neighborhood Hits	219	Shared Neighborhood Hits	33
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHG2_HUMAN
NC score	0.103618 (rank : 288)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	396	Target Neighborhood Hits	142	Shared Neighborhood Hits	31
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

LBC_HUMAN
NC score	0.103451 (rank : 289)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	396	Target Neighborhood Hits	90	Shared Neighborhood Hits	23
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ITK_MOUSE
NC score	0.103291 (rank : 290)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	396	Target Neighborhood Hits	985	Shared Neighborhood Hits	129
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SRMS_MOUSE
NC score	0.103016 (rank : 291)	θ value	0.62314 (rank : 218)
Query Neighborhood Hits	396	Target Neighborhood Hits	964	Shared Neighborhood Hits	113
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

GRB7_MOUSE
NC score	0.101736 (rank : 292)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	396	Target Neighborhood Hits	157	Shared Neighborhood Hits	54
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

FGD3_HUMAN
NC score	0.101704 (rank : 293)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	396	Target Neighborhood Hits	249	Shared Neighborhood Hits	31
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

MPP6_MOUSE
NC score	0.101620 (rank : 294)	θ value	5.27518 (rank : 330)
Query Neighborhood Hits	396	Target Neighborhood Hits	187	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

SAMN1_MOUSE
NC score	0.100744 (rank : 295)	θ value	6.88961 (rank : 366)
Query Neighborhood Hits	396	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

GNRP_HUMAN
NC score	0.100300 (rank : 296)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	396	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

FGD2_HUMAN
NC score	0.099238 (rank : 297)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	396	Target Neighborhood Hits	151	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

DOCK2_HUMAN
NC score	0.098925 (rank : 298)	θ value	3.0926 (rank : 292)
Query Neighborhood Hits	396	Target Neighborhood Hits	90	Shared Neighborhood Hits	48
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

MATK_MOUSE
NC score	0.098229 (rank : 299)	θ value	1.38821 (rank : 249)
Query Neighborhood Hits	396	Target Neighborhood Hits	952	Shared Neighborhood Hits	95
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

ARHG2_MOUSE
NC score	0.098151 (rank : 300)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	396	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

DOCK2_MOUSE
NC score	0.097002 (rank : 301)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	396	Target Neighborhood Hits	104	Shared Neighborhood Hits	45
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

RHG12_HUMAN
NC score	0.096360 (rank : 302)	θ value	8.99809 (rank : 388)
Query Neighborhood Hits	396	Target Neighborhood Hits	190	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SRMS_HUMAN
NC score	0.096021 (rank : 303)	θ value	0.47712 (rank : 203)
Query Neighborhood Hits	396	Target Neighborhood Hits	946	Shared Neighborhood Hits	91
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FGD2_MOUSE
NC score	0.094218 (rank : 304)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	396	Target Neighborhood Hits	163	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

MAP1B_HUMAN
NC score	0.094102 (rank : 305)	θ value	0.00869519 (rank : 123)
Query Neighborhood Hits	396	Target Neighborhood Hits	903	Shared Neighborhood Hits	79
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

FGD1_HUMAN
NC score	0.093058 (rank : 306)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	396	Target Neighborhood Hits	367	Shared Neighborhood Hits	48
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

PPIP2_HUMAN
NC score	0.091715 (rank : 307)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	396	Target Neighborhood Hits	254	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

3BP1_HUMAN
NC score	0.091711 (rank : 308)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	396	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

MATK_HUMAN
NC score	0.091626 (rank : 309)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	396	Target Neighborhood Hits	954	Shared Neighborhood Hits	90
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SH24A_HUMAN
NC score	0.090505 (rank : 310)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	396	Target Neighborhood Hits	455	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

MAP1B_MOUSE
NC score	0.089801 (rank : 311)	θ value	0.00390308 (rank : 110)
Query Neighborhood Hits	396	Target Neighborhood Hits	977	Shared Neighborhood Hits	74
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

FGD1_MOUSE
NC score	0.089389 (rank : 312)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	396	Target Neighborhood Hits	387	Shared Neighborhood Hits	44
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GRB7_HUMAN
NC score	0.089312 (rank : 313)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	396	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

RUSC2_MOUSE
NC score	0.089246 (rank : 314)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	396	Target Neighborhood Hits	305	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SH21A_MOUSE
NC score	0.089080 (rank : 315)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	396	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

MDC1_HUMAN
NC score	0.089043 (rank : 316)	θ value	0.00102713 (rank : 97)
Query Neighborhood Hits	396	Target Neighborhood Hits	1446	Shared Neighborhood Hits	111
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

DOCK4_MOUSE
NC score	0.088269 (rank : 317)	θ value	0.125558 (rank : 165)
Query Neighborhood Hits	396	Target Neighborhood Hits	210	Shared Neighborhood Hits	41
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

SH21A_HUMAN
NC score	0.088131 (rank : 318)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	396	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

DOCK4_HUMAN
NC score	0.087384 (rank : 319)	θ value	0.125558 (rank : 164)
Query Neighborhood Hits	396	Target Neighborhood Hits	237	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

FGD6_MOUSE
NC score	0.086056 (rank : 320)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	396	Target Neighborhood Hits	282	Shared Neighborhood Hits	43
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

APS_MOUSE
NC score	0.085684 (rank : 321)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	396	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

LCP2_MOUSE
NC score	0.084417 (rank : 322)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	396	Target Neighborhood Hits	177	Shared Neighborhood Hits	51
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SH2D3_MOUSE
NC score	0.084200 (rank : 323)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	396	Target Neighborhood Hits	174	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

PTN11_MOUSE
NC score	0.084082 (rank : 324)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.084070 (rank : 325)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	396	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

DOCK3_MOUSE
NC score	0.084044 (rank : 326)	θ value	0.47712 (rank : 196)
Query Neighborhood Hits	396	Target Neighborhood Hits	93	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

FARP2_MOUSE
NC score	0.083748 (rank : 327)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	396	Target Neighborhood Hits	209	Shared Neighborhood Hits	36
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SH22A_MOUSE
NC score	0.083521 (rank : 328)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	396	Target Neighborhood Hits	179	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

PPIP2_MOUSE
NC score	0.083478 (rank : 329)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	396	Target Neighborhood Hits	308	Shared Neighborhood Hits	34
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

GRB10_MOUSE
NC score	0.083302 (rank : 330)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	396	Target Neighborhood Hits	156	Shared Neighborhood Hits	47
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

SOCS2_MOUSE
NC score	0.083015 (rank : 331)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	396	Target Neighborhood Hits	94	Shared Neighborhood Hits	36
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

CYLC1_HUMAN
NC score	0.082851 (rank : 332)	θ value	0.00390308 (rank : 108)
Query Neighborhood Hits	396	Target Neighborhood Hits	408	Shared Neighborhood Hits	44
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

GRB10_HUMAN
NC score	0.082349 (rank : 333)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	396	Target Neighborhood Hits	147	Shared Neighborhood Hits	49
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

SOCS7_MOUSE
NC score	0.081830 (rank : 334)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	396	Target Neighborhood Hits	154	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

LCP2_HUMAN
NC score	0.081762 (rank : 335)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	396	Target Neighborhood Hits	531	Shared Neighborhood Hits	81
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PKHG4_HUMAN
NC score	0.081528 (rank : 336)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	396	Target Neighborhood Hits	200	Shared Neighborhood Hits	28
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

DOCK3_HUMAN
NC score	0.080792 (rank : 337)	θ value	0.47712 (rank : 195)
Query Neighborhood Hits	396	Target Neighborhood Hits	87	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

BCAR3_HUMAN
NC score	0.080435 (rank : 338)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	396	Target Neighborhood Hits	129	Shared Neighborhood Hits	41
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

MPP5_HUMAN
NC score	0.080216 (rank : 339)	θ value	6.88961 (rank : 359)
Query Neighborhood Hits	396	Target Neighborhood Hits	231	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

BCAR3_MOUSE
NC score	0.080132 (rank : 340)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	396	Target Neighborhood Hits	127	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

FER_HUMAN
NC score	0.079988 (rank : 341)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	396	Target Neighborhood Hits	1278	Shared Neighborhood Hits	104
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SH2D3_HUMAN
NC score	0.079743 (rank : 342)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	396	Target Neighborhood Hits	188	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

MPP5_MOUSE
NC score	0.079428 (rank : 343)	θ value	6.88961 (rank : 360)
Query Neighborhood Hits	396	Target Neighborhood Hits	226	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

SOCS2_HUMAN
NC score	0.079009 (rank : 344)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	396	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

REN3B_HUMAN
NC score	0.079005 (rank : 345)	θ value	0.00869519 (rank : 126)
Query Neighborhood Hits	396	Target Neighborhood Hits	412	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

TRIO_HUMAN
NC score	0.078711 (rank : 346)	θ value	0.365318 (rank : 192)
Query Neighborhood Hits	396	Target Neighborhood Hits	1580	Shared Neighborhood Hits	131
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SOCS6_MOUSE
NC score	0.077766 (rank : 347)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	396	Target Neighborhood Hits	146	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

HSH2D_MOUSE
NC score	0.077562 (rank : 348)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	396	Target Neighborhood Hits	124	Shared Neighborhood Hits	32
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SH22A_HUMAN
NC score	0.076934 (rank : 349)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	396	Target Neighborhood Hits	144	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH24A_MOUSE
NC score	0.076911 (rank : 350)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	396	Target Neighborhood Hits	326	Shared Neighborhood Hits	70
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SOCS6_HUMAN
NC score	0.076116 (rank : 351)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	396	Target Neighborhood Hits	126	Shared Neighborhood Hits	39
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

CHIO_MOUSE
NC score	0.075215 (rank : 352)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	396	Target Neighborhood Hits	130	Shared Neighborhood Hits	27
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

FGD6_HUMAN
NC score	0.075199 (rank : 353)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	396	Target Neighborhood Hits	237	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

BLNK_MOUSE
NC score	0.073984 (rank : 354)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	396	Target Neighborhood Hits	296	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

SH23A_HUMAN
NC score	0.073765 (rank : 355)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	396	Target Neighborhood Hits	149	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

BMX_MOUSE
NC score	0.073698 (rank : 356)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	396	Target Neighborhood Hits	912	Shared Neighborhood Hits	68
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BMX_HUMAN
NC score	0.073694 (rank : 357)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	396	Target Neighborhood Hits	942	Shared Neighborhood Hits	68
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SRRM2_HUMAN
NC score	0.073585 (rank : 358)	θ value	0.365318 (rank : 191)
Query Neighborhood Hits	396	Target Neighborhood Hits	1296	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

GMIP_MOUSE
NC score	0.073476 (rank : 359)	θ value	0.813845 (rank : 227)
Query Neighborhood Hits	396	Target Neighborhood Hits	202	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

KSYK_MOUSE
NC score	0.073450 (rank : 360)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	396	Target Neighborhood Hits	944	Shared Neighborhood Hits	78
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

PTN6_MOUSE
NC score	0.073212 (rank : 361)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

FARP2_HUMAN
NC score	0.073082 (rank : 362)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	396	Target Neighborhood Hits	240	Shared Neighborhood Hits	33
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ZAP70_MOUSE
NC score	0.072554 (rank : 363)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	396	Target Neighborhood Hits	905	Shared Neighborhood Hits	71
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

MAP1A_HUMAN
NC score	0.072458 (rank : 364)	θ value	3.0926 (rank : 294)
Query Neighborhood Hits	396	Target Neighborhood Hits	1626	Shared Neighborhood Hits	112
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

SRRM2_MOUSE
NC score	0.072070 (rank : 365)	θ value	0.813845 (rank : 231)
Query Neighborhood Hits	396	Target Neighborhood Hits	1470	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

NRAP_MOUSE
NC score	0.072062 (rank : 366)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	396	Target Neighborhood Hits	167	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

ZAP70_HUMAN
NC score	0.071690 (rank : 367)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	396	Target Neighborhood Hits	893	Shared Neighborhood Hits	71
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

PTN6_HUMAN
NC score	0.071476 (rank : 368)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	396	Target Neighborhood Hits	234	Shared Neighborhood Hits	57
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

NRAP_HUMAN
NC score	0.071469 (rank : 369)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	396	Target Neighborhood Hits	159	Shared Neighborhood Hits	9
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

RBBP6_MOUSE
NC score	0.071395 (rank : 370)	θ value	0.279714 (rank : 185)
Query Neighborhood Hits	396	Target Neighborhood Hits	1014	Shared Neighborhood Hits	67
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

KSYK_HUMAN
NC score	0.071372 (rank : 371)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	396	Target Neighborhood Hits	901	Shared Neighborhood Hits	70
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FARP1_HUMAN
NC score	0.071335 (rank : 372)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	396	Target Neighborhood Hits	241	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ACK1_MOUSE
NC score	0.071201 (rank : 373)	θ value	6.88961 (rank : 343)
Query Neighborhood Hits	396	Target Neighborhood Hits	1080	Shared Neighborhood Hits	112
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACK1_HUMAN
NC score	0.070704 (rank : 374)	θ value	6.88961 (rank : 342)
Query Neighborhood Hits	396	Target Neighborhood Hits	1140	Shared Neighborhood Hits	112
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

MPP2_MOUSE
NC score	0.070133 (rank : 375)	θ value	8.99809 (rank : 385)
Query Neighborhood Hits	396	Target Neighborhood Hits	189	Shared Neighborhood Hits	70
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

CISH_HUMAN
NC score	0.069959 (rank : 376)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	396	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

BLNK_HUMAN
NC score	0.069897 (rank : 377)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	396	Target Neighborhood Hits	228	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CISH_MOUSE
NC score	0.069253 (rank : 378)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	396	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

MPP2_HUMAN
NC score	0.068991 (rank : 379)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	396	Target Neighborhood Hits	173	Shared Neighborhood Hits	70
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

S3TC2_HUMAN
NC score	0.067965 (rank : 380)	θ value	1.81305 (rank : 270)
Query Neighborhood Hits	396	Target Neighborhood Hits	70	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

GMIP_HUMAN
NC score	0.067174 (rank : 381)	θ value	6.88961 (rank : 352)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

TEX14_MOUSE
NC score	0.066442 (rank : 382)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	396	Target Neighborhood Hits	1333	Shared Neighborhood Hits	101
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_HUMAN
NC score	0.065997 (rank : 383)	θ value	8.99809 (rank : 395)
Query Neighborhood Hits	396	Target Neighborhood Hits	1103	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

NACAM_MOUSE
NC score	0.065220 (rank : 384)	θ value	1.81305 (rank : 265)
Query Neighborhood Hits	396	Target Neighborhood Hits	1866	Shared Neighborhood Hits	139
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PCLO_HUMAN
NC score	0.064999 (rank : 385)	θ value	1.38821 (rank : 251)
Query Neighborhood Hits	396	Target Neighborhood Hits	2046	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

OPHN1_HUMAN
NC score	0.064456 (rank : 386)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	396	Target Neighborhood Hits	161	Shared Neighborhood Hits	27
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

TENS4_HUMAN
NC score	0.064423 (rank : 387)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	396	Target Neighborhood Hits	214	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

RHG25_MOUSE
NC score	0.064321 (rank : 388)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	396	Target Neighborhood Hits	492	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

3BP1_MOUSE
NC score	0.063362 (rank : 389)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	396	Target Neighborhood Hits	238	Shared Neighborhood Hits	42
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

MPP4_MOUSE
NC score	0.063087 (rank : 390)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	396	Target Neighborhood Hits	188	Shared Neighborhood Hits	65
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

TENS4_MOUSE
NC score	0.063072 (rank : 391)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	396	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

RBBP6_HUMAN
NC score	0.062449 (rank : 392)	θ value	0.47712 (rank : 200)
Query Neighborhood Hits	396	Target Neighborhood Hits	1135	Shared Neighborhood Hits	78
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

OPHN1_MOUSE
NC score	0.061589 (rank : 393)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	396	Target Neighborhood Hits	174	Shared Neighborhood Hits	27
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

DUET_HUMAN
NC score	0.060775 (rank : 394)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	396	Target Neighborhood Hits	1220	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

SOS1_HUMAN
NC score	0.059996 (rank : 395)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	396	Target Neighborhood Hits	274	Shared Neighborhood Hits	41
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

REPS2_HUMAN
NC score	0.059931 (rank : 396)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	396	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

FES_HUMAN
NC score	0.058848 (rank : 397)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	396	Target Neighborhood Hits	978	Shared Neighborhood Hits	66
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ILK_MOUSE
NC score	0.058098 (rank : 398)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	396	Target Neighborhood Hits	858	Shared Neighborhood Hits	58
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.057859 (rank : 399)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	396	Target Neighborhood Hits	857	Shared Neighborhood Hits	58
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

SOS1_MOUSE
NC score	0.057845 (rank : 400)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	396	Target Neighborhood Hits	281	Shared Neighborhood Hits	46
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TACC2_HUMAN
NC score	0.057649 (rank : 401)	θ value	0.0736092 (rank : 155)
Query Neighborhood Hits	396	Target Neighborhood Hits	856	Shared Neighborhood Hits	79
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

LMO7_HUMAN
NC score	0.057516 (rank : 402)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	396	Target Neighborhood Hits	507	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

ILK2_HUMAN
NC score	0.057186 (rank : 403)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	396	Target Neighborhood Hits	848	Shared Neighborhood Hits	58
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

MPP4_HUMAN
NC score	0.057073 (rank : 404)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	396	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

REPS2_MOUSE
NC score	0.056072 (rank : 405)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	396	Target Neighborhood Hits	102	Shared Neighborhood Hits	15
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

FES_MOUSE
NC score	0.055879 (rank : 406)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	396	Target Neighborhood Hits	980	Shared Neighborhood Hits	62
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

RHG25_HUMAN
NC score	0.055460 (rank : 407)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	396	Target Neighborhood Hits	550	Shared Neighborhood Hits	45
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TNK1_MOUSE
NC score	0.055331 (rank : 408)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	396	Target Neighborhood Hits	806	Shared Neighborhood Hits	53
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

MDC1_MOUSE
NC score	0.055220 (rank : 409)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	396	Target Neighborhood Hits	998	Shared Neighborhood Hits	86
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

TNK1_HUMAN
NC score	0.055024 (rank : 410)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	396	Target Neighborhood Hits	815	Shared Neighborhood Hits	56
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TP53B_MOUSE
NC score	0.054884 (rank : 411)	θ value	0.0961366 (rank : 161)
Query Neighborhood Hits	396	Target Neighborhood Hits	644	Shared Neighborhood Hits	55
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

CSKP_MOUSE
NC score	0.054856 (rank : 412)	θ value	5.27518 (rank : 321)
Query Neighborhood Hits	396	Target Neighborhood Hits	1027	Shared Neighborhood Hits	137
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSKP_HUMAN
NC score	0.054826 (rank : 413)	θ value	6.88961 (rank : 348)
Query Neighborhood Hits	396	Target Neighborhood Hits	1022	Shared Neighborhood Hits	130
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

RYK_HUMAN
NC score	0.054752 (rank : 414)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	396	Target Neighborhood Hits	701	Shared Neighborhood Hits	42
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

LTK_HUMAN
NC score	0.054465 (rank : 415)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	396	Target Neighborhood Hits	774	Shared Neighborhood Hits	46
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

RPB1_HUMAN
NC score	0.054430 (rank : 416)	θ value	0.47712 (rank : 201)
Query Neighborhood Hits	396	Target Neighborhood Hits	362	Shared Neighborhood Hits	48
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RYK_MOUSE
NC score	0.054151 (rank : 417)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	396	Target Neighborhood Hits	715	Shared Neighborhood Hits	42
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SOCS1_MOUSE
NC score	0.054060 (rank : 418)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	396	Target Neighborhood Hits	82	Shared Neighborhood Hits	28
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

LTK_MOUSE
NC score	0.053980 (rank : 419)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	396	Target Neighborhood Hits	770	Shared Neighborhood Hits	47
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

SRRM1_MOUSE
NC score	0.053953 (rank : 420)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	396	Target Neighborhood Hits	966	Shared Neighborhood Hits	91
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ALK_MOUSE
NC score	0.053612 (rank : 421)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	396	Target Neighborhood Hits	811	Shared Neighborhood Hits	52
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

STYK1_MOUSE
NC score	0.053521 (rank : 422)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	396	Target Neighborhood Hits	779	Shared Neighborhood Hits	45
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

RFIP1_HUMAN
NC score	0.053416 (rank : 423)	θ value	0.813845 (rank : 230)
Query Neighborhood Hits	396	Target Neighborhood Hits	236	Shared Neighborhood Hits	31
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

SOCS1_HUMAN
NC score	0.053314 (rank : 424)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	396	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

S3TC2_MOUSE
NC score	0.053084 (rank : 425)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	396	Target Neighborhood Hits	83	Shared Neighborhood Hits	47
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

MLL2_HUMAN
NC score	0.053021 (rank : 426)	θ value	1.06291 (rank : 239)
Query Neighborhood Hits	396	Target Neighborhood Hits	1788	Shared Neighborhood Hits	117
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ROS_HUMAN
NC score	0.053012 (rank : 427)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	396	Target Neighborhood Hits	907	Shared Neighborhood Hits	50
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

STYK1_HUMAN
NC score	0.052965 (rank : 428)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	396	Target Neighborhood Hits	786	Shared Neighborhood Hits	45
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

RPB1_MOUSE
NC score	0.052888 (rank : 429)	θ value	0.47712 (rank : 202)
Query Neighborhood Hits	396	Target Neighborhood Hits	363	Shared Neighborhood Hits	46
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

ALK_HUMAN
NC score	0.052856 (rank : 430)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	396	Target Neighborhood Hits	795	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

MIA_MOUSE
NC score	0.052626 (rank : 431)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	396	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

AATK_MOUSE
NC score	0.052602 (rank : 432)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	396	Target Neighborhood Hits	942	Shared Neighborhood Hits	62
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

MIA_HUMAN
NC score	0.052540 (rank : 433)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	396	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

TAGAP_HUMAN
NC score	0.052403 (rank : 434)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	396	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

MYO9B_HUMAN
NC score	0.052292 (rank : 435)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	396	Target Neighborhood Hits	641	Shared Neighborhood Hits	66
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

SRRM1_HUMAN
NC score	0.052267 (rank : 436)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	396	Target Neighborhood Hits	690	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

PI5PA_HUMAN
NC score	0.052021 (rank : 437)	θ value	0.00665767 (rank : 121)
Query Neighborhood Hits	396	Target Neighborhood Hits	749	Shared Neighborhood Hits	57
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

DDR1_MOUSE
NC score	0.051856 (rank : 438)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	396	Target Neighborhood Hits	818	Shared Neighborhood Hits	47
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.051400 (rank : 439)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	396	Target Neighborhood Hits	819	Shared Neighborhood Hits	47
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

RHG06_HUMAN
NC score	0.051314 (rank : 440)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	396	Target Neighborhood Hits	114	Shared Neighborhood Hits	23
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RGAP1_MOUSE
NC score	0.051067 (rank : 441)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	396	Target Neighborhood Hits	185	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

AATK_HUMAN
NC score	0.051056 (rank : 442)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	396	Target Neighborhood Hits	1243	Shared Neighborhood Hits	79
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

EPHAA_HUMAN
NC score	0.051054 (rank : 443)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	396	Target Neighborhood Hits	960	Shared Neighborhood Hits	52
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_HUMAN
NC score	0.050716 (rank : 444)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	396	Target Neighborhood Hits	912	Shared Neighborhood Hits	50
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

TXND2_HUMAN
NC score	0.050695 (rank : 445)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	396	Target Neighborhood Hits	793	Shared Neighborhood Hits	75
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

NPBL_MOUSE
NC score	0.050595 (rank : 446)	θ value	6.88961 (rank : 362)
Query Neighborhood Hits	396	Target Neighborhood Hits	1041	Shared Neighborhood Hits	77
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

TGON2_HUMAN
NC score	0.050428 (rank : 447)	θ value	4.03905 (rank : 314)
Query Neighborhood Hits	396	Target Neighborhood Hits	1037	Shared Neighborhood Hits	95
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

FAK2_HUMAN
NC score	0.050420 (rank : 448)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	396	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TARA_HUMAN
NC score	0.050397 (rank : 449)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	396	Target Neighborhood Hits	1626	Shared Neighborhood Hits	115
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

FAK2_MOUSE
NC score	0.050392 (rank : 450)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	396	Target Neighborhood Hits	851	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ERBB2_HUMAN
NC score	0.050359 (rank : 451)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	396	Target Neighborhood Hits	1073	Shared Neighborhood Hits	55
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB4_HUMAN
NC score	0.050349 (rank : 452)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	396	Target Neighborhood Hits	910	Shared Neighborhood Hits	50
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

FLT3_MOUSE
NC score	0.050305 (rank : 453)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	396	Target Neighborhood Hits	847	Shared Neighborhood Hits	46
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

GSCR1_HUMAN
NC score	0.050236 (rank : 454)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	396	Target Neighborhood Hits	674	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

ERBB3_HUMAN
NC score	0.050188 (rank : 455)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	396	Target Neighborhood Hits	918	Shared Neighborhood Hits	44
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB2_MOUSE
NC score	0.050103 (rank : 456)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	396	Target Neighborhood Hits	918	Shared Neighborhood Hits	48
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_MOUSE
NC score	0.050039 (rank : 457)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	396	Target Neighborhood Hits	898	Shared Neighborhood Hits	48
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

FLT3_HUMAN
NC score	0.050029 (rank : 458)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	396	Target Neighborhood Hits	843	Shared Neighborhood Hits	45
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

SOCS3_HUMAN
NC score	0.050017 (rank : 459)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	396	Target Neighborhood Hits	77	Shared Neighborhood Hits	29
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

DLG2_MOUSE
NC score	0.050013 (rank : 460)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	396	Target Neighborhood Hits	271	Shared Neighborhood Hits	75
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

AFF4_HUMAN
NC score	0.049686 (rank : 461)	θ value	0.813845 (rank : 226)
Query Neighborhood Hits	396	Target Neighborhood Hits	611	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

K0240_MOUSE
NC score	0.049657 (rank : 462)	θ value	0.163984 (rank : 168)
Query Neighborhood Hits	396	Target Neighborhood Hits	211	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CHH5	Gene names	Kiaa0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

NIPBL_HUMAN
NC score	0.049218 (rank : 463)	θ value	0.62314 (rank : 216)
Query Neighborhood Hits	396	Target Neighborhood Hits	1311	Shared Neighborhood Hits	86
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

AFF4_MOUSE
NC score	0.048816 (rank : 464)	θ value	3.0926 (rank : 286)
Query Neighborhood Hits	396	Target Neighborhood Hits	581	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ZC313_HUMAN
NC score	0.048807 (rank : 465)	θ value	6.88961 (rank : 370)
Query Neighborhood Hits	396	Target Neighborhood Hits	772	Shared Neighborhood Hits	64
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ACINU_HUMAN
NC score	0.048783 (rank : 466)	θ value	3.0926 (rank : 285)
Query Neighborhood Hits	396	Target Neighborhood Hits	828	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ATX2_HUMAN
NC score	0.048114 (rank : 467)	θ value	0.0563607 (rank : 145)
Query Neighborhood Hits	396	Target Neighborhood Hits	375	Shared Neighborhood Hits	36
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

STAR8_HUMAN
NC score	0.046871 (rank : 468)	θ value	8.99809 (rank : 391)
Query Neighborhood Hits	396	Target Neighborhood Hits	216	Shared Neighborhood Hits	31
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

MY18A_MOUSE
NC score	0.046225 (rank : 469)	θ value	2.36792 (rank : 280)
Query Neighborhood Hits	396	Target Neighborhood Hits	1989	Shared Neighborhood Hits	105
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

TARA_MOUSE
NC score	0.044933 (rank : 470)	θ value	4.03905 (rank : 312)
Query Neighborhood Hits	396	Target Neighborhood Hits	1133	Shared Neighborhood Hits	92
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

NFH_MOUSE
NC score	0.044336 (rank : 471)	θ value	0.279714 (rank : 184)
Query Neighborhood Hits	396	Target Neighborhood Hits	2247	Shared Neighborhood Hits	141
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

GGN_HUMAN
NC score	0.043972 (rank : 472)	θ value	6.88961 (rank : 351)
Query Neighborhood Hits	396	Target Neighborhood Hits	269	Shared Neighborhood Hits	37
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

RGS3_MOUSE
NC score	0.043739 (rank : 473)	θ value	6.88961 (rank : 364)
Query Neighborhood Hits	396	Target Neighborhood Hits	1621	Shared Neighborhood Hits	120
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

AFF1_HUMAN
NC score	0.043563 (rank : 474)	θ value	8.99809 (rank : 371)
Query Neighborhood Hits	396	Target Neighborhood Hits	506	Shared Neighborhood Hits	52
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

NCOR2_HUMAN
NC score	0.043372 (rank : 475)	θ value	1.81305 (rank : 266)
Query Neighborhood Hits	396	Target Neighborhood Hits	870	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

SON_HUMAN
NC score	0.042571 (rank : 476)	θ value	5.27518 (rank : 339)
Query Neighborhood Hits	396	Target Neighborhood Hits	1568	Shared Neighborhood Hits	114
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

MAP9_HUMAN
NC score	0.042472 (rank : 477)	θ value	1.81305 (rank : 262)
Query Neighborhood Hits	396	Target Neighborhood Hits	518	Shared Neighborhood Hits	48
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

MYH10_MOUSE
NC score	0.041299 (rank : 478)	θ value	1.81305 (rank : 264)
Query Neighborhood Hits	396	Target Neighborhood Hits	1612	Shared Neighborhood Hits	90
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

SMC1A_MOUSE
NC score	0.041165 (rank : 479)	θ value	4.03905 (rank : 309)
Query Neighborhood Hits	396	Target Neighborhood Hits	1384	Shared Neighborhood Hits	85
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

MILK1_HUMAN
NC score	0.040903 (rank : 480)	θ value	1.38821 (rank : 250)
Query Neighborhood Hits	396	Target Neighborhood Hits	427	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SMC1A_HUMAN
NC score	0.040781 (rank : 481)	θ value	4.03905 (rank : 308)
Query Neighborhood Hits	396	Target Neighborhood Hits	1346	Shared Neighborhood Hits	82
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

CSKI2_MOUSE
NC score	0.040477 (rank : 482)	θ value	6.88961 (rank : 347)
Query Neighborhood Hits	396	Target Neighborhood Hits	812	Shared Neighborhood Hits	93
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

MYH10_HUMAN
NC score	0.040324 (rank : 483)	θ value	1.81305 (rank : 263)
Query Neighborhood Hits	396	Target Neighborhood Hits	1620	Shared Neighborhood Hits	88
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

BAT3_HUMAN
NC score	0.039805 (rank : 484)	θ value	0.62314 (rank : 211)
Query Neighborhood Hits	396	Target Neighborhood Hits	490	Shared Neighborhood Hits	43
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

SPT5H_HUMAN
NC score	0.039363 (rank : 485)	θ value	4.03905 (rank : 310)
Query Neighborhood Hits	396	Target Neighborhood Hits	436	Shared Neighborhood Hits	44
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

TRIPB_HUMAN
NC score	0.039067 (rank : 486)	θ value	0.62314 (rank : 222)
Query Neighborhood Hits	396	Target Neighborhood Hits	1587	Shared Neighborhood Hits	87
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

DIDO1_HUMAN
NC score	0.038917 (rank : 487)	θ value	0.279714 (rank : 180)
Query Neighborhood Hits	396	Target Neighborhood Hits	960	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

ANR11_HUMAN
NC score	0.038616 (rank : 488)	θ value	5.27518 (rank : 316)
Query Neighborhood Hits	396	Target Neighborhood Hits	1289	Shared Neighborhood Hits	104
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

CD008_HUMAN
NC score	0.038399 (rank : 489)	θ value	2.36792 (rank : 273)
Query Neighborhood Hits	396	Target Neighborhood Hits	330	Shared Neighborhood Hits	31
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

SPT5H_MOUSE
NC score	0.038230 (rank : 490)	θ value	4.03905 (rank : 311)
Query Neighborhood Hits	396	Target Neighborhood Hits	437	Shared Neighborhood Hits	43
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

MX1_MOUSE
NC score	0.038019 (rank : 491)	θ value	0.0330416 (rank : 141)
Query Neighborhood Hits	396	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P09922	Gene names	Mx1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein).

RPGR1_MOUSE
NC score	0.037999 (rank : 492)	θ value	3.0926 (rank : 296)
Query Neighborhood Hits	396	Target Neighborhood Hits	713	Shared Neighborhood Hits	52
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

K2027_HUMAN
NC score	0.037554 (rank : 493)	θ value	0.62314 (rank : 214)
Query Neighborhood Hits	396	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

THAP4_MOUSE
NC score	0.037399 (rank : 494)	θ value	0.163984 (rank : 172)
Query Neighborhood Hits	396	Target Neighborhood Hits	130	Shared Neighborhood Hits	15
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

TCAL5_HUMAN
NC score	0.037372 (rank : 495)	θ value	0.62314 (rank : 220)
Query Neighborhood Hits	396	Target Neighborhood Hits	806	Shared Neighborhood Hits	55
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

FA21C_HUMAN
NC score	0.037269 (rank : 496)	θ value	2.36792 (rank : 277)
Query Neighborhood Hits	396	Target Neighborhood Hits	194	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

RSF1_HUMAN
NC score	0.037247 (rank : 497)	θ value	3.0926 (rank : 297)
Query Neighborhood Hits	396	Target Neighborhood Hits	539	Shared Neighborhood Hits	47
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

AAT1_MOUSE
NC score	0.037036 (rank : 498)	θ value	0.62314 (rank : 206)
Query Neighborhood Hits	396	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BRC6	Gene names	Aat1
Domain Architecture	No domain graphic available
Description	AMY-1-associating protein expressed in testis 1 homolog (AAT-1).

K0240_HUMAN
NC score	0.036797 (rank : 499)	θ value	1.81305 (rank : 261)
Query Neighborhood Hits	396	Target Neighborhood Hits	96	Shared Neighborhood Hits	7
SwissProt Accessions	Q6AI39, Q5TFZ3, Q92514	Gene names	KIAA0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

TCAL3_HUMAN
NC score	0.035671 (rank : 500)	θ value	0.47712 (rank : 204)
Query Neighborhood Hits	396	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q969E4	Gene names	TCEAL3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

OXR1_MOUSE
NC score	0.035657 (rank : 501)	θ value	5.27518 (rank : 333)
Query Neighborhood Hits	396	Target Neighborhood Hits	516	Shared Neighborhood Hits	51
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

SCG2_HUMAN
NC score	0.035390 (rank : 502)	θ value	0.365318 (rank : 190)
Query Neighborhood Hits	396	Target Neighborhood Hits	190	Shared Neighborhood Hits	19
SwissProt Accessions	P13521, Q8TBH3	Gene names	SCG2, CHGC
Domain Architecture
Description	Secretogranin-2 precursor (Secretogranin II) (SgII) (Chromogranin C) [Contains: Secretoneurin (SN)].

K1802_MOUSE
NC score	0.035044 (rank : 503)	θ value	0.47712 (rank : 197)
Query Neighborhood Hits	396	Target Neighborhood Hits	1596	Shared Neighborhood Hits	101
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MYH7_HUMAN
NC score	0.034512 (rank : 504)	θ value	5.27518 (rank : 331)
Query Neighborhood Hits	396	Target Neighborhood Hits	1559	Shared Neighborhood Hits	71
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MPP8_HUMAN
NC score	0.034503 (rank : 505)	θ value	1.06291 (rank : 240)
Query Neighborhood Hits	396	Target Neighborhood Hits	948	Shared Neighborhood Hits	74
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

STK10_HUMAN
NC score	0.034404 (rank : 506)	θ value	8.99809 (rank : 392)
Query Neighborhood Hits	396	Target Neighborhood Hits	1921	Shared Neighborhood Hits	109
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

DMD_HUMAN
NC score	0.033765 (rank : 507)	θ value	8.99809 (rank : 379)
Query Neighborhood Hits	396	Target Neighborhood Hits	1135	Shared Neighborhood Hits	60
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

NFH_HUMAN
NC score	0.032376 (rank : 508)	θ value	1.81305 (rank : 267)
Query Neighborhood Hits	396	Target Neighborhood Hits	1242	Shared Neighborhood Hits	94
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TOP1_HUMAN
NC score	0.031995 (rank : 509)	θ value	0.62314 (rank : 221)
Query Neighborhood Hits	396	Target Neighborhood Hits	207	Shared Neighborhood Hits	25
SwissProt Accessions	P11387, O43256, Q12855, Q12856, Q15610, Q5TFY3, Q9UJN0	Gene names	TOP1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

CT2NL_MOUSE
NC score	0.031742 (rank : 510)	θ value	8.99809 (rank : 377)
Query Neighborhood Hits	396	Target Neighborhood Hits	902	Shared Neighborhood Hits	60
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

TNIK_HUMAN
NC score	0.031448 (rank : 511)	θ value	8.99809 (rank : 396)
Query Neighborhood Hits	396	Target Neighborhood Hits	1570	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

DMD_MOUSE
NC score	0.031262 (rank : 512)	θ value	8.99809 (rank : 380)
Query Neighborhood Hits	396	Target Neighborhood Hits	1111	Shared Neighborhood Hits	60
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

MAML2_HUMAN
NC score	0.030594 (rank : 513)	θ value	6.88961 (rank : 357)
Query Neighborhood Hits	396	Target Neighborhood Hits	360	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

ICAL_HUMAN
NC score	0.028760 (rank : 514)	θ value	6.88961 (rank : 353)
Query Neighborhood Hits	396	Target Neighborhood Hits	275	Shared Neighborhood Hits	35
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

NKTR_HUMAN
NC score	0.028691 (rank : 515)	θ value	0.125558 (rank : 167)
Query Neighborhood Hits	396	Target Neighborhood Hits	658	Shared Neighborhood Hits	44
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PP4R1_MOUSE
NC score	0.027927 (rank : 516)	θ value	1.06291 (rank : 241)
Query Neighborhood Hits	396	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

MAGC1_HUMAN
NC score	0.027854 (rank : 517)	θ value	0.0736092 (rank : 153)
Query Neighborhood Hits	396	Target Neighborhood Hits	431	Shared Neighborhood Hits	46
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

WDR60_MOUSE
NC score	0.027797 (rank : 518)	θ value	6.88961 (rank : 368)
Query Neighborhood Hits	396	Target Neighborhood Hits	344	Shared Neighborhood Hits	38
SwissProt Accessions	Q8C761, Q3UNM4	Gene names	Wdr60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

BCL9_HUMAN
NC score	0.027517 (rank : 519)	θ value	5.27518 (rank : 318)
Query Neighborhood Hits	396	Target Neighborhood Hits	1008	Shared Neighborhood Hits	67
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CROCC_MOUSE
NC score	0.027480 (rank : 520)	θ value	3.0926 (rank : 291)
Query Neighborhood Hits	396	Target Neighborhood Hits	1460	Shared Neighborhood Hits	77
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

MARK2_HUMAN
NC score	0.027287 (rank : 521)	θ value	3.0926 (rank : 295)
Query Neighborhood Hits	396	Target Neighborhood Hits	1056	Shared Neighborhood Hits	67
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

IF4B_MOUSE
NC score	0.027060 (rank : 522)	θ value	3.0926 (rank : 293)
Query Neighborhood Hits	396	Target Neighborhood Hits	368	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

SPEG_HUMAN
NC score	0.026694 (rank : 523)	θ value	8.99809 (rank : 390)
Query Neighborhood Hits	396	Target Neighborhood Hits	1762	Shared Neighborhood Hits	104
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MPP10_MOUSE
NC score	0.026291 (rank : 524)	θ value	2.36792 (rank : 279)
Query Neighborhood Hits	396	Target Neighborhood Hits	251	Shared Neighborhood Hits	22
SwissProt Accessions	Q810V0	Gene names	Mphosph10
Domain Architecture	No domain graphic available
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

BRSK1_HUMAN
NC score	0.025642 (rank : 525)	θ value	5.27518 (rank : 320)
Query Neighborhood Hits	396	Target Neighborhood Hits	942	Shared Neighborhood Hits	60
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

FMN2_HUMAN
NC score	0.025450 (rank : 526)	θ value	4.03905 (rank : 304)
Query Neighborhood Hits	396	Target Neighborhood Hits	484	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

SETD2_HUMAN
NC score	0.024895 (rank : 527)	θ value	4.03905 (rank : 307)
Query Neighborhood Hits	396	Target Neighborhood Hits	412	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

ZAN_HUMAN
NC score	0.024750 (rank : 528)	θ value	0.62314 (rank : 224)
Query Neighborhood Hits	396	Target Neighborhood Hits	679	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

RPGR_HUMAN
NC score	0.024298 (rank : 529)	θ value	1.38821 (rank : 252)
Query Neighborhood Hits	396	Target Neighborhood Hits	279	Shared Neighborhood Hits	22
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RP3A_MOUSE
NC score	0.022917 (rank : 530)	θ value	6.88961 (rank : 365)
Query Neighborhood Hits	396	Target Neighborhood Hits	510	Shared Neighborhood Hits	37
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

NFRKB_MOUSE
NC score	0.022810 (rank : 531)	θ value	8.99809 (rank : 386)
Query Neighborhood Hits	396	Target Neighborhood Hits	393	Shared Neighborhood Hits	34
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

PKHA6_HUMAN
NC score	0.022367 (rank : 532)	θ value	0.62314 (rank : 217)
Query Neighborhood Hits	396	Target Neighborhood Hits	556	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

EF1D_MOUSE
NC score	0.021794 (rank : 533)	θ value	5.27518 (rank : 323)
Query Neighborhood Hits	396	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	P57776, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5	Gene names	Eef1d
Domain Architecture
Description	Elongation factor 1-delta (EF-1-delta).

BCOR_HUMAN
NC score	0.021413 (rank : 534)	θ value	4.03905 (rank : 301)
Query Neighborhood Hits	396	Target Neighborhood Hits	609	Shared Neighborhood Hits	45
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CEL_HUMAN
NC score	0.020782 (rank : 535)	θ value	1.38821 (rank : 245)
Query Neighborhood Hits	396	Target Neighborhood Hits	896	Shared Neighborhood Hits	62
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

ADDA_MOUSE
NC score	0.020287 (rank : 536)	θ value	5.27518 (rank : 315)
Query Neighborhood Hits	396	Target Neighborhood Hits	198	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

SNIP_MOUSE
NC score	0.020012 (rank : 537)	θ value	5.27518 (rank : 338)
Query Neighborhood Hits	396	Target Neighborhood Hits	319	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

MAVS_MOUSE
NC score	0.019899 (rank : 538)	θ value	8.99809 (rank : 384)
Query Neighborhood Hits	396	Target Neighborhood Hits	170	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

JUN_MOUSE
NC score	0.019610 (rank : 539)	θ value	1.06291 (rank : 237)
Query Neighborhood Hits	396	Target Neighborhood Hits	145	Shared Neighborhood Hits	7
SwissProt Accessions	P05627	Gene names	Jun
Domain Architecture
Description	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A) (AH119).

PASK_MOUSE
NC score	0.019603 (rank : 540)	θ value	5.27518 (rank : 334)
Query Neighborhood Hits	396	Target Neighborhood Hits	867	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

EBP2_MOUSE
NC score	0.019544 (rank : 541)	θ value	5.27518 (rank : 322)
Query Neighborhood Hits	396	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D903, Q3TKB5	Gene names	Ebna1bp2, Ebp2
Domain Architecture
Description	Probable rRNA-processing protein EBP2.

DPOLZ_HUMAN
NC score	0.019428 (rank : 542)	θ value	2.36792 (rank : 275)
Query Neighborhood Hits	396	Target Neighborhood Hits	200	Shared Neighborhood Hits	19
SwissProt Accessions	O60673, O43214	Gene names	REV3L, POLZ, REV3
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (hREV3).

IRS2_MOUSE
NC score	0.018563 (rank : 543)	θ value	6.88961 (rank : 354)
Query Neighborhood Hits	396	Target Neighborhood Hits	248	Shared Neighborhood Hits	31
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

CNOT4_MOUSE
NC score	0.018559 (rank : 544)	θ value	8.99809 (rank : 376)
Query Neighborhood Hits	396	Target Neighborhood Hits	277	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

HOMEZ_HUMAN
NC score	0.018486 (rank : 545)	θ value	2.36792 (rank : 278)
Query Neighborhood Hits	396	Target Neighborhood Hits	110	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IX15, Q6P049, Q86XB6, Q9P2A5	Gene names	HOMEZ, KIAA1443
Domain Architecture
Description	Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper- containing factor).

KIF4A_MOUSE
NC score	0.018467 (rank : 546)	θ value	8.99809 (rank : 383)
Query Neighborhood Hits	396	Target Neighborhood Hits	1033	Shared Neighborhood Hits	51
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

TOPRS_MOUSE
NC score	0.018441 (rank : 547)	θ value	1.38821 (rank : 258)
Query Neighborhood Hits	396	Target Neighborhood Hits	263	Shared Neighborhood Hits	11
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

PYR1_HUMAN
NC score	0.018415 (rank : 548)	θ value	1.06291 (rank : 242)
Query Neighborhood Hits	396	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

CAR10_MOUSE
NC score	0.018091 (rank : 549)	θ value	6.88961 (rank : 344)
Query Neighborhood Hits	396	Target Neighborhood Hits	407	Shared Neighborhood Hits	25
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

KCTD8_HUMAN
NC score	0.017950 (rank : 550)	θ value	0.365318 (rank : 188)
Query Neighborhood Hits	396	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZWB6	Gene names	KCTD8
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD8.

UBP29_MOUSE
NC score	0.017835 (rank : 551)	θ value	0.62314 (rank : 223)
Query Neighborhood Hits	396	Target Neighborhood Hits	95	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ES63	Gene names	Usp29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

DEN1A_HUMAN
NC score	0.017773 (rank : 552)	θ value	2.36792 (rank : 274)
Query Neighborhood Hits	396	Target Neighborhood Hits	176	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

ETV3_HUMAN
NC score	0.017593 (rank : 553)	θ value	2.36792 (rank : 276)
Query Neighborhood Hits	396	Target Neighborhood Hits	312	Shared Neighborhood Hits	32
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

ELK4_HUMAN
NC score	0.017351 (rank : 554)	θ value	1.06291 (rank : 234)
Query Neighborhood Hits	396	Target Neighborhood Hits	184	Shared Neighborhood Hits	19
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

ANKR6_HUMAN
NC score	0.016672 (rank : 555)	θ value	1.81305 (rank : 259)
Query Neighborhood Hits	396	Target Neighborhood Hits	439	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

CNOT4_HUMAN
NC score	0.016082 (rank : 556)	θ value	6.88961 (rank : 346)
Query Neighborhood Hits	396	Target Neighborhood Hits	207	Shared Neighborhood Hits	14
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

TBX2_HUMAN
NC score	0.015958 (rank : 557)	θ value	0.62314 (rank : 219)
Query Neighborhood Hits	396	Target Neighborhood Hits	195	Shared Neighborhood Hits	18
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

ELOA1_MOUSE
NC score	0.015935 (rank : 558)	θ value	5.27518 (rank : 324)
Query Neighborhood Hits	396	Target Neighborhood Hits	152	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CB77, Q80VB2, Q9R0Q5	Gene names	Tceb3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

MMAC_HUMAN
NC score	0.015929 (rank : 559)	θ value	6.88961 (rank : 358)
Query Neighborhood Hits	396	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4U1, Q5T157, Q9BRQ7	Gene names	MMACHC
Domain Architecture	No domain graphic available
Description	Methylmalonic aciduria and homocystinuria type C protein.

PDE1A_HUMAN
NC score	0.015313 (rank : 560)	θ value	0.47712 (rank : 199)
Query Neighborhood Hits	396	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

LIPB2_MOUSE
NC score	0.014955 (rank : 561)	θ value	5.27518 (rank : 326)
Query Neighborhood Hits	396	Target Neighborhood Hits	570	Shared Neighborhood Hits	33
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

PDE1A_MOUSE
NC score	0.014461 (rank : 562)	θ value	0.813845 (rank : 229)
Query Neighborhood Hits	396	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

DYXC1_MOUSE
NC score	0.014404 (rank : 563)	θ value	6.88961 (rank : 350)
Query Neighborhood Hits	396	Target Neighborhood Hits	172	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R368	Gene names	Dyx1c1, Ekn1
Domain Architecture
Description	Dyslexia susceptibility 1 candidate gene 1 protein homolog.

CC28A_HUMAN
NC score	0.014098 (rank : 564)	θ value	6.88961 (rank : 345)
Query Neighborhood Hits	396	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWP9, Q66K67, Q96E23, Q9Y430	Gene names	CCDC28A, C6orf80
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 28A (CCRL1AP).

SOX30_MOUSE
NC score	0.013722 (rank : 565)	θ value	3.0926 (rank : 300)
Query Neighborhood Hits	396	Target Neighborhood Hits	374	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

TEF_MOUSE
NC score	0.013365 (rank : 566)	θ value	8.99809 (rank : 394)
Query Neighborhood Hits	396	Target Neighborhood Hits	68	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JLC6, Q3U426, Q3UGF4, Q3UM49, Q3URC8, Q6QHT6, Q8C6I0, Q8VD02	Gene names	Tef
Domain Architecture	No domain graphic available
Description	Thyrotroph embryonic factor.

RED_HUMAN
NC score	0.013073 (rank : 567)	θ value	8.99809 (rank : 387)
Query Neighborhood Hits	396	Target Neighborhood Hits	79	Shared Neighborhood Hits	9
SwissProt Accessions	Q13123	Gene names	IK, RED, RER
Domain Architecture	No domain graphic available
Description	Protein Red (Protein RER) (IK factor) (Cytokine IK).

CHD1_HUMAN
NC score	0.012119 (rank : 568)	θ value	3.0926 (rank : 288)
Query Neighborhood Hits	396	Target Neighborhood Hits	337	Shared Neighborhood Hits	22
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

K0323_HUMAN
NC score	0.011874 (rank : 569)	θ value	6.88961 (rank : 355)
Query Neighborhood Hits	396	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	O15037, Q86TZ6, Q8IUQ2, Q96BA9	Gene names	KIAA0323
Domain Architecture	No domain graphic available
Description	Protein KIAA0323.

TBX2_MOUSE
NC score	0.011790 (rank : 570)	θ value	4.03905 (rank : 313)
Query Neighborhood Hits	396	Target Neighborhood Hits	97	Shared Neighborhood Hits	12
SwissProt Accessions	Q60707	Gene names	Tbx2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

NOC2L_HUMAN
NC score	0.011554 (rank : 571)	θ value	6.88961 (rank : 361)
Query Neighborhood Hits	396	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y3T9, Q5SVA3, Q9BTN6	Gene names	NOC2L
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

ZFHX2_HUMAN
NC score	0.011437 (rank : 572)	θ value	0.47712 (rank : 205)
Query Neighborhood Hits	396	Target Neighborhood Hits	1178	Shared Neighborhood Hits	32
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

CHD4_MOUSE
NC score	0.011345 (rank : 573)	θ value	4.03905 (rank : 303)
Query Neighborhood Hits	396	Target Neighborhood Hits	408	Shared Neighborhood Hits	31
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

RT31_HUMAN
NC score	0.011145 (rank : 574)	θ value	8.99809 (rank : 389)
Query Neighborhood Hits	396	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q92665, Q5VYC8, Q8WTV8	Gene names	MRPS31, IMOGN38
Domain Architecture	No domain graphic available
Description	28S ribosomal protein S31, mitochondrial precursor (S31mt) (MRP-S31) (Imogen 38).

ATF4_HUMAN
NC score	0.010933 (rank : 575)	θ value	8.99809 (rank : 373)
Query Neighborhood Hits	396	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P18848, Q9UH31	Gene names	ATF4
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-4 (Activating transcription factor 4) (DNA-binding protein TAXREB67) (Cyclic AMP response element-binding protein 2) (CREB2).

CD248_MOUSE
NC score	0.010711 (rank : 576)	θ value	1.38821 (rank : 244)
Query Neighborhood Hits	396	Target Neighborhood Hits	578	Shared Neighborhood Hits	28
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

XRCC3_MOUSE
NC score	0.010061 (rank : 577)	θ value	6.88961 (rank : 369)
Query Neighborhood Hits	396	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CXE6	Gene names	Xrcc3
Domain Architecture	No domain graphic available
Description	DNA-repair protein XRCC3 (X-ray repair cross-complementing protein 3).

WHRN_HUMAN
NC score	0.009885 (rank : 578)	θ value	2.36792 (rank : 284)
Query Neighborhood Hits	396	Target Neighborhood Hits	325	Shared Neighborhood Hits	23
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

CHD4_HUMAN
NC score	0.009836 (rank : 579)	θ value	4.03905 (rank : 302)
Query Neighborhood Hits	396	Target Neighborhood Hits	365	Shared Neighborhood Hits	25
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

OAS3_HUMAN
NC score	0.009638 (rank : 580)	θ value	5.27518 (rank : 332)
Query Neighborhood Hits	396	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6K5, Q9H3P5	Gene names	OAS3
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 3 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 3) (2-5A synthetase 3) (p100 OAS) (p100OAS).

MARE2_HUMAN
NC score	0.009497 (rank : 581)	θ value	5.27518 (rank : 328)
Query Neighborhood Hits	396	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q15555, Q9UQ33	Gene names	MAPRE2, RP1
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2).

LPIN2_MOUSE
NC score	0.008989 (rank : 582)	θ value	5.27518 (rank : 327)
Query Neighborhood Hits	396	Target Neighborhood Hits	60	Shared Neighborhood Hits	9
SwissProt Accessions	Q99PI5, Q8C357, Q8C7I8, Q8CC85, Q8CHR7	Gene names	Lpin2
Domain Architecture
Description	Lipin-2.

DCX_HUMAN
NC score	0.008690 (rank : 583)	θ value	8.99809 (rank : 378)
Query Neighborhood Hits	396	Target Neighborhood Hits	141	Shared Neighborhood Hits	18
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

SORC1_HUMAN
NC score	0.008501 (rank : 584)	θ value	3.0926 (rank : 299)
Query Neighborhood Hits	396	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

PVRL1_HUMAN
NC score	0.007867 (rank : 585)	θ value	2.36792 (rank : 281)
Query Neighborhood Hits	396	Target Neighborhood Hits	219	Shared Neighborhood Hits	4
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

CLIC6_HUMAN
NC score	0.007401 (rank : 586)	θ value	8.99809 (rank : 375)
Query Neighborhood Hits	396	Target Neighborhood Hits	289	Shared Neighborhood Hits	18
SwissProt Accessions	Q96NY7, Q8IX31	Gene names	CLIC6, CLIC1L
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

CONA1_MOUSE
NC score	0.007092 (rank : 587)	θ value	3.0926 (rank : 290)
Query Neighborhood Hits	396	Target Neighborhood Hits	254	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

CONA1_HUMAN
NC score	0.006587 (rank : 588)	θ value	3.0926 (rank : 289)
Query Neighborhood Hits	396	Target Neighborhood Hits	281	Shared Neighborhood Hits	20
SwissProt Accessions	Q86Y22, Q8IVR4, Q9NT93	Gene names	COL23A1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

SNTG2_HUMAN
NC score	0.005469 (rank : 589)	θ value	6.88961 (rank : 367)
Query Neighborhood Hits	396	Target Neighborhood Hits	191	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

CAC1B_HUMAN
NC score	0.003892 (rank : 590)	θ value	8.99809 (rank : 374)
Query Neighborhood Hits	396	Target Neighborhood Hits	257	Shared Neighborhood Hits	19
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

HXB3_HUMAN
NC score	0.003327 (rank : 591)	θ value	1.38821 (rank : 247)
Query Neighborhood Hits	396	Target Neighborhood Hits	559	Shared Neighborhood Hits	24
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

HXC10_MOUSE
NC score	0.003051 (rank : 592)	θ value	5.27518 (rank : 325)
Query Neighborhood Hits	396	Target Neighborhood Hits	417	Shared Neighborhood Hits	21
SwissProt Accessions	P31257, P31312, Q7TMT7	Gene names	Hoxc10, Hox-3.6, Hoxc-10
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C10 (Hox-3.6).

KIF9_MOUSE
NC score	0.002514 (rank : 593)	θ value	6.88961 (rank : 356)
Query Neighborhood Hits	396	Target Neighborhood Hits	147	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WV04, O35070	Gene names	Kif9
Domain Architecture
Description	Kinesin-like protein KIF9.

HXC10_HUMAN
NC score	0.002020 (rank : 594)	θ value	8.99809 (rank : 382)
Query Neighborhood Hits	396	Target Neighborhood Hits	417	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

BOC_HUMAN
NC score	0.000830 (rank : 595)	θ value	3.0926 (rank : 287)
Query Neighborhood Hits	396	Target Neighborhood Hits	543	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

DUX4_HUMAN
NC score	0.000370 (rank : 596)	θ value	8.99809 (rank : 381)
Query Neighborhood Hits	396	Target Neighborhood Hits	403	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UBX2	Gene names	DUX4, DUX10
Domain Architecture	No domain graphic available
Description	Double homeobox protein 4 (Double homeobox protein 10) (Double homeobox protein 4/10).

DLX4_HUMAN
NC score	-0.000271 (rank : 597)	θ value	6.88961 (rank : 349)
Query Neighborhood Hits	396	Target Neighborhood Hits	350	Shared Neighborhood Hits	10
SwissProt Accessions	Q92988, O60480, Q13265, Q6PJK0, Q9HBE0	Gene names	DLX4, BP1, DLX7, DLX8
Domain Architecture	No domain graphic available
Description	Homeobox protein DLX-4 (DLX-7) (DLX-8) (Beta protein 1).

PCDA2_HUMAN
NC score	-0.002222 (rank : 598)	θ value	4.03905 (rank : 305)
Query Neighborhood Hits	396	Target Neighborhood Hits	192	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5H9, O75287, Q9BTV3	Gene names	PCDHA2
Domain Architecture
Description	Protocadherin alpha 2 precursor (PCDH-alpha2).

ZN174_HUMAN
NC score	-0.007291 (rank : 599)	θ value	0.62314 (rank : 225)
Query Neighborhood Hits	396	Target Neighborhood Hits	744	Shared Neighborhood Hits	11
SwissProt Accessions	Q15697, Q9BQ34	Gene names	ZNF174, ZSCAN8
Domain Architecture
Description	Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8).

ZBT11_HUMAN
NC score	-0.009006 (rank : 600)	θ value	5.27518 (rank : 341)
Query Neighborhood Hits	396	Target Neighborhood Hits	873	Shared Neighborhood Hits	12
SwissProt Accessions	O95625	Gene names	ZBTB11
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 11.