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Network neighborhood for query Sequence : DOCK3_HUMAN

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DOCK3_HUMAN
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DOCK1_HUMAN
θ value	0 (rank : 1)	NC score	0.946309 (rank : 7)
Query Neighborhood Hits	87	Target Neighborhood Hits	191	Shared Neighborhood Hits	31
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DOCK2_HUMAN
θ value	0 (rank : 2)	NC score	0.967079 (rank : 5)
Query Neighborhood Hits	87	Target Neighborhood Hits	90	Shared Neighborhood Hits	29
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
θ value	0 (rank : 3)	NC score	0.964422 (rank : 6)
Query Neighborhood Hits	87	Target Neighborhood Hits	104	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DOCK3_HUMAN
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	0 (rank : 5)	NC score	0.998419 (rank : 2)
Query Neighborhood Hits	87	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK4_HUMAN
θ value	0 (rank : 6)	NC score	0.977561 (rank : 4)
Query Neighborhood Hits	87	Target Neighborhood Hits	237	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	0 (rank : 7)	NC score	0.978150 (rank : 3)
Query Neighborhood Hits	87	Target Neighborhood Hits	210	Shared Neighborhood Hits	32
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOC10_HUMAN
θ value	1.13037e-18 (rank : 8)	NC score	0.492703 (rank : 8)
Query Neighborhood Hits	87	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DOCK9_MOUSE
θ value	3.63628e-17 (rank : 9)	NC score	0.455938 (rank : 9)
Query Neighborhood Hits	87	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_HUMAN
θ value	1.80466e-16 (rank : 10)	NC score	0.452725 (rank : 11)
Query Neighborhood Hits	87	Target Neighborhood Hits	82	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK8_MOUSE
θ value	6.41864e-14 (rank : 11)	NC score	0.453237 (rank : 10)
Query Neighborhood Hits	87	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C147, Q6PIS0, Q7TMQ5, Q8K105, Q9DBQ2	Gene names	Dock8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK7_HUMAN
θ value	1.86753e-13 (rank : 12)	NC score	0.440049 (rank : 13)
Query Neighborhood Hits	87	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q96N67, Q6ZV32, Q8TB82, Q96NG6, Q9C092	Gene names	DOCK7, KIAA1771
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 7.

DOCK8_HUMAN
θ value	4.16044e-13 (rank : 13)	NC score	0.443549 (rank : 12)
Query Neighborhood Hits	87	Target Neighborhood Hits	42	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK6_HUMAN
θ value	5.43371e-13 (rank : 14)	NC score	0.426459 (rank : 14)
Query Neighborhood Hits	87	Target Neighborhood Hits	71	Shared Neighborhood Hits	14
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

DNMBP_MOUSE
θ value	0.0563607 (rank : 15)	NC score	0.095728 (rank : 16)
Query Neighborhood Hits	87	Target Neighborhood Hits	435	Shared Neighborhood Hits	27
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRBS1_MOUSE
θ value	0.163984 (rank : 16)	NC score	0.078488 (rank : 20)
Query Neighborhood Hits	87	Target Neighborhood Hits	409	Shared Neighborhood Hits	26
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

DNMBP_HUMAN
θ value	0.279714 (rank : 17)	NC score	0.101930 (rank : 15)
Query Neighborhood Hits	87	Target Neighborhood Hits	413	Shared Neighborhood Hits	23
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

IMB1_MOUSE
θ value	0.279714 (rank : 18)	NC score	0.054425 (rank : 22)
Query Neighborhood Hits	87	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

IMB1_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.052860 (rank : 23)
Query Neighborhood Hits	87	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

SAPS1_HUMAN
θ value	0.47712 (rank : 20)	NC score	0.022823 (rank : 37)
Query Neighborhood Hits	87	Target Neighborhood Hits	704	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SRBS1_HUMAN
θ value	0.47712 (rank : 21)	NC score	0.080792 (rank : 19)
Query Neighborhood Hits	87	Target Neighborhood Hits	396	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

M3K9_HUMAN
θ value	0.62314 (rank : 22)	NC score	0.013999 (rank : 48)
Query Neighborhood Hits	87	Target Neighborhood Hits	1123	Shared Neighborhood Hits	27
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

VINEX_HUMAN
θ value	0.62314 (rank : 23)	NC score	0.089725 (rank : 17)
Query Neighborhood Hits	87	Target Neighborhood Hits	270	Shared Neighborhood Hits	24
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	0.62314 (rank : 24)	NC score	0.088825 (rank : 18)
Query Neighborhood Hits	87	Target Neighborhood Hits	286	Shared Neighborhood Hits	22
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

APOB_HUMAN
θ value	0.813845 (rank : 25)	NC score	0.046511 (rank : 24)
Query Neighborhood Hits	87	Target Neighborhood Hits	202	Shared Neighborhood Hits	7
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

CBP_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.019090 (rank : 43)
Query Neighborhood Hits	87	Target Neighborhood Hits	1051	Shared Neighborhood Hits	18
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

NCOA6_HUMAN
θ value	1.06291 (rank : 27)	NC score	0.037807 (rank : 29)
Query Neighborhood Hits	87	Target Neighborhood Hits	1202	Shared Neighborhood Hits	25
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NUMA1_HUMAN
θ value	1.06291 (rank : 28)	NC score	0.005548 (rank : 75)
Query Neighborhood Hits	87	Target Neighborhood Hits	1523	Shared Neighborhood Hits	16
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

S40A1_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.042388 (rank : 27)
Query Neighborhood Hits	87	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NP59, Q7Z4F8, Q8IVB2, Q9NRL0	Gene names	SLC40A1, FPN1, IREG1, SLC11A3
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1).

ARLY_MOUSE
θ value	1.81305 (rank : 30)	NC score	0.028352 (rank : 35)
Query Neighborhood Hits	87	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YI0, Q3UFA2	Gene names	Asl
Domain Architecture
Description	Argininosuccinate lyase (EC 4.3.2.1) (Arginosuccinase) (ASAL).

LYN_HUMAN
θ value	1.81305 (rank : 31)	NC score	0.010617 (rank : 58)
Query Neighborhood Hits	87	Target Neighborhood Hits	1022	Shared Neighborhood Hits	26
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MLL3_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.020201 (rank : 42)
Query Neighborhood Hits	87	Target Neighborhood Hits	1644	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SAS6_MOUSE
θ value	1.81305 (rank : 33)	NC score	0.009991 (rank : 59)
Query Neighborhood Hits	87	Target Neighborhood Hits	931	Shared Neighborhood Hits	9
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

AKA12_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.012700 (rank : 50)
Query Neighborhood Hits	87	Target Neighborhood Hits	825	Shared Neighborhood Hits	13
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

ANK2_HUMAN
θ value	2.36792 (rank : 35)	NC score	0.006920 (rank : 73)
Query Neighborhood Hits	87	Target Neighborhood Hits	1615	Shared Neighborhood Hits	29
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CP11A_MOUSE
θ value	2.36792 (rank : 36)	NC score	0.008345 (rank : 66)
Query Neighborhood Hits	87	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QZ82	Gene names	Cyp11a1, Cyp11a
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

ITSN1_MOUSE
θ value	2.36792 (rank : 37)	NC score	0.034330 (rank : 31)
Query Neighborhood Hits	87	Target Neighborhood Hits	1669	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NDST1_MOUSE
θ value	2.36792 (rank : 38)	NC score	0.011076 (rank : 56)
Query Neighborhood Hits	87	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UHN9, O70353, Q3TBX3, Q3TDS3, Q8BZE5, Q9R206	Gene names	Ndst1
Domain Architecture	No domain graphic available
Description	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST- 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) (N- heparan sulfate sulfotransferase 1) (N-HSST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.-.-.-); Heparan sulfate N- sulfotransferase 1 (EC 2.8.2.-)].

S40A1_MOUSE
θ value	2.36792 (rank : 39)	NC score	0.036231 (rank : 30)
Query Neighborhood Hits	87	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHI9, Q3UHZ9, Q8BME5, Q8BUM5, Q9JIM9, Q9JKP4	Gene names	Slc40a1, Fpn1, Ireg1, Slc11a3, Slc39a1
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1).

TNAP2_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.025026 (rank : 36)
Query Neighborhood Hits	87	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q03169, Q86VI0	Gene names	TNFAIP2
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 2 (Primary response gene B94 protein).

ASXL1_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.012834 (rank : 49)
Query Neighborhood Hits	87	Target Neighborhood Hits	260	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

ITSN1_HUMAN
θ value	3.0926 (rank : 42)	NC score	0.032709 (rank : 32)
Query Neighborhood Hits	87	Target Neighborhood Hits	1757	Shared Neighborhood Hits	39
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

LYN_MOUSE
θ value	3.0926 (rank : 43)	NC score	0.011270 (rank : 55)
Query Neighborhood Hits	87	Target Neighborhood Hits	1023	Shared Neighborhood Hits	26
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NELFB_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.029629 (rank : 33)
Query Neighborhood Hits	87	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WX92, Q96EW5, Q9H9R4, Q9ULN8, Q9Y3W0	Gene names	NELFB, COBRA1, KIAA1182
Domain Architecture
Description	Negative elongation factor B (NELF-B) (Cofactor of BRCA1).

NELFB_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.029452 (rank : 34)
Query Neighborhood Hits	87	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C4Y3, Q99J41, Q9JJA5	Gene names	Nelfb
Domain Architecture
Description	Negative elongation factor B (NELF-B).

OXR1_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.017161 (rank : 45)
Query Neighborhood Hits	87	Target Neighborhood Hits	516	Shared Neighborhood Hits	13
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

RRBP1_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.005081 (rank : 76)
Query Neighborhood Hits	87	Target Neighborhood Hits	1650	Shared Neighborhood Hits	19
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

TITIN_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.002539 (rank : 84)
Query Neighborhood Hits	87	Target Neighborhood Hits	2923	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ULK1_HUMAN
θ value	3.0926 (rank : 49)	NC score	0.001974 (rank : 86)
Query Neighborhood Hits	87	Target Neighborhood Hits	1121	Shared Neighborhood Hits	15
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ATF1_MOUSE
θ value	4.03905 (rank : 50)	NC score	0.015781 (rank : 47)
Query Neighborhood Hits	87	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	P81269	Gene names	Atf1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-1 (Activating transcription factor 1) (TCR-ATF1).

MUC1_MOUSE
θ value	4.03905 (rank : 51)	NC score	0.017776 (rank : 44)
Query Neighborhood Hits	87	Target Neighborhood Hits	388	Shared Neighborhood Hits	14
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

MYO15_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.009832 (rank : 61)
Query Neighborhood Hits	87	Target Neighborhood Hits	467	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

AT131_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.008986 (rank : 64)
Query Neighborhood Hits	87	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HD20, Q9H6C6	Gene names	ATP13A1, ATP13A, KIAA1825
Domain Architecture
Description	Probable cation-transporting ATPase 13A1 (EC 3.6.3.-).

AT131_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.009061 (rank : 63)
Query Neighborhood Hits	87	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPE9	Gene names	Atp13a1, Atp13a
Domain Architecture
Description	Probable cation-transporting ATPase 13A1 (EC 3.6.3.-) (CATP).

IRK4_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.007280 (rank : 70)
Query Neighborhood Hits	87	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	P48050	Gene names	KCNJ4
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2).

IRK4_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.007283 (rank : 69)
Query Neighborhood Hits	87	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	P52189	Gene names	Kcnj4, Irk3
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (IRK3).

KIF1A_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.002680 (rank : 83)
Query Neighborhood Hits	87	Target Neighborhood Hits	239	Shared Neighborhood Hits	4
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

RNF12_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.010848 (rank : 57)
Query Neighborhood Hits	87	Target Neighborhood Hits	173	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

3BP1_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.022113 (rank : 38)
Query Neighborhood Hits	87	Target Neighborhood Hits	376	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AL2SB_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.009096 (rank : 62)
Query Neighborhood Hits	87	Target Neighborhood Hits	294	Shared Neighborhood Hits	9
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

GP115_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.007157 (rank : 72)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IZF3, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6	Gene names	GPR115, PGR18
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 115 (G-protein coupled receptor PGR18).

HRX_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.022087 (rank : 39)
Query Neighborhood Hits	87	Target Neighborhood Hits	825	Shared Neighborhood Hits	20
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

IMPG1_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.009988 (rank : 60)
Query Neighborhood Hits	87	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R1W8, Q9CTP8, Q9ES62, Q9ET31	Gene names	Impg1, Spacr
Domain Architecture	No domain graphic available
Description	Interphotoreceptor matrix proteoglycan 1 precursor (IPM 150 proteoglycan) (Sialoprotein associated with cones and rods).

NELFA_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.041795 (rank : 28)
Query Neighborhood Hits	87	Target Neighborhood Hits	195	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9	Gene names	Whsc2, Nelfa, Whsc2h
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2).

PTN14_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.003519 (rank : 80)
Query Neighborhood Hits	87	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

S6A14_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.004271 (rank : 78)
Query Neighborhood Hits	87	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMA9, Q91Y60, Q9D317, Q9R183	Gene names	Slc6a14
Domain Architecture
Description	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Colonic system B0+ amino acid transporter CATB0+) (Solute carrier family 6 member 14).

SI1L1_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.016660 (rank : 46)
Query Neighborhood Hits	87	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SPRE3_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.011340 (rank : 54)
Query Neighborhood Hits	87	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

SPTA1_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.011655 (rank : 53)
Query Neighborhood Hits	87	Target Neighborhood Hits	748	Shared Neighborhood Hits	22
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRC8_HUMAN
θ value	6.88961 (rank : 70)	NC score	0.045389 (rank : 25)
Query Neighborhood Hits	87	Target Neighborhood Hits	269	Shared Neighborhood Hits	21
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	6.88961 (rank : 71)	NC score	0.043862 (rank : 26)
Query Neighborhood Hits	87	Target Neighborhood Hits	292	Shared Neighborhood Hits	21
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRRM2_MOUSE
θ value	6.88961 (rank : 72)	NC score	0.020276 (rank : 41)
Query Neighborhood Hits	87	Target Neighborhood Hits	1470	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SYNP2_MOUSE
θ value	6.88961 (rank : 73)	NC score	0.007900 (rank : 67)
Query Neighborhood Hits	87	Target Neighborhood Hits	252	Shared Neighborhood Hits	14
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

WNK4_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.002246 (rank : 85)
Query Neighborhood Hits	87	Target Neighborhood Hits	961	Shared Neighborhood Hits	18
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

APC_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.008926 (rank : 65)
Query Neighborhood Hits	87	Target Neighborhood Hits	603	Shared Neighborhood Hits	12
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

BUB1B_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.006894 (rank : 74)
Query Neighborhood Hits	87	Target Neighborhood Hits	208	Shared Neighborhood Hits	7
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

EHMT2_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.007163 (rank : 71)
Query Neighborhood Hits	87	Target Neighborhood Hits	750	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

FOXC2_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.004024 (rank : 79)
Query Neighborhood Hits	87	Target Neighborhood Hits	236	Shared Neighborhood Hits	10
SwissProt Accessions	Q99958	Gene names	FOXC2, FKHL14, MFH1
Domain Architecture
Description	Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14).

LRRK2_HUMAN
θ value	8.99809 (rank : 79)	NC score	-0.000530 (rank : 88)
Query Neighborhood Hits	87	Target Neighborhood Hits	1382	Shared Neighborhood Hits	11
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

PCX1_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.011791 (rank : 52)
Query Neighborhood Hits	87	Target Neighborhood Hits	102	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RV3, O94897, Q96AI7, Q9Y2J9	Gene names	PCNX, KIAA0805, KIAA0995, PCNXL1
Domain Architecture
Description	Pecanex-like protein 1 (Pecanex homolog).

RHPN1_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.007643 (rank : 68)
Query Neighborhood Hits	87	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SEPT9_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.003498 (rank : 81)
Query Neighborhood Hits	87	Target Neighborhood Hits	706	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SNX18_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.021480 (rank : 40)
Query Neighborhood Hits	87	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

TLK2_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.000999 (rank : 87)
Query Neighborhood Hits	87	Target Neighborhood Hits	1044	Shared Neighborhood Hits	14
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLR4_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.003095 (rank : 82)
Query Neighborhood Hits	87	Target Neighborhood Hits	298	Shared Neighborhood Hits	4
SwissProt Accessions	O00206, Q9UK78, Q9UM57	Gene names	TLR4
Domain Architecture
Description	Toll-like receptor 4 precursor (hToll) (CD284 antigen).

TTLL5_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.004879 (rank : 77)
Query Neighborhood Hits	87	Target Neighborhood Hits	141	Shared Neighborhood Hits	5
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

U383_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.012119 (rank : 51)
Query Neighborhood Hits	87	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2Q2, Q3V1K3	Gene names
Domain Architecture	No domain graphic available
Description	Putative methyltransferase UPF0383 (EC 2.1.1.-).

HCLS1_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.056285 (rank : 21)
Query Neighborhood Hits	87	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

Hits sorted by NC score

DOCK3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
NC score	0.998419 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	87	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK4_MOUSE
NC score	0.978150 (rank : 3)	θ value	0 (rank : 7)
Query Neighborhood Hits	87	Target Neighborhood Hits	210	Shared Neighborhood Hits	32
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_HUMAN
NC score	0.977561 (rank : 4)	θ value	0 (rank : 6)
Query Neighborhood Hits	87	Target Neighborhood Hits	237	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK2_HUMAN
NC score	0.967079 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	87	Target Neighborhood Hits	90	Shared Neighborhood Hits	29
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
NC score	0.964422 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	87	Target Neighborhood Hits	104	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DOCK1_HUMAN
NC score	0.946309 (rank : 7)	θ value	0 (rank : 1)
Query Neighborhood Hits	87	Target Neighborhood Hits	191	Shared Neighborhood Hits	31
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DOC10_HUMAN
NC score	0.492703 (rank : 8)	θ value	1.13037e-18 (rank : 8)
Query Neighborhood Hits	87	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DOCK9_MOUSE
NC score	0.455938 (rank : 9)	θ value	3.63628e-17 (rank : 9)
Query Neighborhood Hits	87	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK8_MOUSE
NC score	0.453237 (rank : 10)	θ value	6.41864e-14 (rank : 11)
Query Neighborhood Hits	87	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C147, Q6PIS0, Q7TMQ5, Q8K105, Q9DBQ2	Gene names	Dock8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK9_HUMAN
NC score	0.452725 (rank : 11)	θ value	1.80466e-16 (rank : 10)
Query Neighborhood Hits	87	Target Neighborhood Hits	82	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK8_HUMAN
NC score	0.443549 (rank : 12)	θ value	4.16044e-13 (rank : 13)
Query Neighborhood Hits	87	Target Neighborhood Hits	42	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK7_HUMAN
NC score	0.440049 (rank : 13)	θ value	1.86753e-13 (rank : 12)
Query Neighborhood Hits	87	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q96N67, Q6ZV32, Q8TB82, Q96NG6, Q9C092	Gene names	DOCK7, KIAA1771
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 7.

DOCK6_HUMAN
NC score	0.426459 (rank : 14)	θ value	5.43371e-13 (rank : 14)
Query Neighborhood Hits	87	Target Neighborhood Hits	71	Shared Neighborhood Hits	14
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

DNMBP_HUMAN
NC score	0.101930 (rank : 15)	θ value	0.279714 (rank : 17)
Query Neighborhood Hits	87	Target Neighborhood Hits	413	Shared Neighborhood Hits	23
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
NC score	0.095728 (rank : 16)	θ value	0.0563607 (rank : 15)
Query Neighborhood Hits	87	Target Neighborhood Hits	435	Shared Neighborhood Hits	27
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VINEX_HUMAN
NC score	0.089725 (rank : 17)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	87	Target Neighborhood Hits	270	Shared Neighborhood Hits	24
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.088825 (rank : 18)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	87	Target Neighborhood Hits	286	Shared Neighborhood Hits	22
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRBS1_HUMAN
NC score	0.080792 (rank : 19)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	87	Target Neighborhood Hits	396	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.078488 (rank : 20)	θ value	0.163984 (rank : 16)
Query Neighborhood Hits	87	Target Neighborhood Hits	409	Shared Neighborhood Hits	26
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

HCLS1_HUMAN
NC score	0.056285 (rank : 21)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	87	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

IMB1_MOUSE
NC score	0.054425 (rank : 22)	θ value	0.279714 (rank : 18)
Query Neighborhood Hits	87	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

IMB1_HUMAN
NC score	0.052860 (rank : 23)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	87	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

APOB_HUMAN
NC score	0.046511 (rank : 24)	θ value	0.813845 (rank : 25)
Query Neighborhood Hits	87	Target Neighborhood Hits	202	Shared Neighborhood Hits	7
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

SRC8_HUMAN
NC score	0.045389 (rank : 25)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	87	Target Neighborhood Hits	269	Shared Neighborhood Hits	21
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.043862 (rank : 26)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	87	Target Neighborhood Hits	292	Shared Neighborhood Hits	21
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

S40A1_HUMAN
NC score	0.042388 (rank : 27)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	87	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NP59, Q7Z4F8, Q8IVB2, Q9NRL0	Gene names	SLC40A1, FPN1, IREG1, SLC11A3
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1).

NELFA_MOUSE
NC score	0.041795 (rank : 28)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	87	Target Neighborhood Hits	195	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9	Gene names	Whsc2, Nelfa, Whsc2h
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2).

NCOA6_HUMAN
NC score	0.037807 (rank : 29)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	87	Target Neighborhood Hits	1202	Shared Neighborhood Hits	25
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

S40A1_MOUSE
NC score	0.036231 (rank : 30)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	87	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHI9, Q3UHZ9, Q8BME5, Q8BUM5, Q9JIM9, Q9JKP4	Gene names	Slc40a1, Fpn1, Ireg1, Slc11a3, Slc39a1
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1).

ITSN1_MOUSE
NC score	0.034330 (rank : 31)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	87	Target Neighborhood Hits	1669	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.032709 (rank : 32)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	87	Target Neighborhood Hits	1757	Shared Neighborhood Hits	39
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NELFB_HUMAN
NC score	0.029629 (rank : 33)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	87	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WX92, Q96EW5, Q9H9R4, Q9ULN8, Q9Y3W0	Gene names	NELFB, COBRA1, KIAA1182
Domain Architecture
Description	Negative elongation factor B (NELF-B) (Cofactor of BRCA1).

NELFB_MOUSE
NC score	0.029452 (rank : 34)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	87	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C4Y3, Q99J41, Q9JJA5	Gene names	Nelfb
Domain Architecture
Description	Negative elongation factor B (NELF-B).

ARLY_MOUSE
NC score	0.028352 (rank : 35)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	87	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YI0, Q3UFA2	Gene names	Asl
Domain Architecture
Description	Argininosuccinate lyase (EC 4.3.2.1) (Arginosuccinase) (ASAL).

TNAP2_HUMAN
NC score	0.025026 (rank : 36)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	87	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q03169, Q86VI0	Gene names	TNFAIP2
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 2 (Primary response gene B94 protein).

SAPS1_HUMAN
NC score	0.022823 (rank : 37)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	87	Target Neighborhood Hits	704	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

3BP1_HUMAN
NC score	0.022113 (rank : 38)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	87	Target Neighborhood Hits	376	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

HRX_HUMAN
NC score	0.022087 (rank : 39)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	87	Target Neighborhood Hits	825	Shared Neighborhood Hits	20
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

SNX18_HUMAN
NC score	0.021480 (rank : 40)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	87	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SRRM2_MOUSE
NC score	0.020276 (rank : 41)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	87	Target Neighborhood Hits	1470	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

MLL3_HUMAN
NC score	0.020201 (rank : 42)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	87	Target Neighborhood Hits	1644	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

CBP_MOUSE
NC score	0.019090 (rank : 43)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	87	Target Neighborhood Hits	1051	Shared Neighborhood Hits	18
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

MUC1_MOUSE
NC score	0.017776 (rank : 44)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	87	Target Neighborhood Hits	388	Shared Neighborhood Hits	14
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

OXR1_MOUSE
NC score	0.017161 (rank : 45)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	87	Target Neighborhood Hits	516	Shared Neighborhood Hits	13
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

SI1L1_MOUSE
NC score	0.016660 (rank : 46)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	87	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

ATF1_MOUSE
NC score	0.015781 (rank : 47)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	87	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	P81269	Gene names	Atf1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-1 (Activating transcription factor 1) (TCR-ATF1).

M3K9_HUMAN
NC score	0.013999 (rank : 48)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	87	Target Neighborhood Hits	1123	Shared Neighborhood Hits	27
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ASXL1_HUMAN
NC score	0.012834 (rank : 49)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	87	Target Neighborhood Hits	260	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

AKA12_HUMAN
NC score	0.012700 (rank : 50)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	87	Target Neighborhood Hits	825	Shared Neighborhood Hits	13
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

U383_MOUSE
NC score	0.012119 (rank : 51)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	87	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2Q2, Q3V1K3	Gene names
Domain Architecture	No domain graphic available
Description	Putative methyltransferase UPF0383 (EC 2.1.1.-).

PCX1_HUMAN
NC score	0.011791 (rank : 52)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	87	Target Neighborhood Hits	102	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RV3, O94897, Q96AI7, Q9Y2J9	Gene names	PCNX, KIAA0805, KIAA0995, PCNXL1
Domain Architecture
Description	Pecanex-like protein 1 (Pecanex homolog).

SPTA1_HUMAN
NC score	0.011655 (rank : 53)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	87	Target Neighborhood Hits	748	Shared Neighborhood Hits	22
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPRE3_MOUSE
NC score	0.011340 (rank : 54)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	87	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

LYN_MOUSE
NC score	0.011270 (rank : 55)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	87	Target Neighborhood Hits	1023	Shared Neighborhood Hits	26
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NDST1_MOUSE
NC score	0.011076 (rank : 56)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	87	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UHN9, O70353, Q3TBX3, Q3TDS3, Q8BZE5, Q9R206	Gene names	Ndst1
Domain Architecture	No domain graphic available
Description	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST- 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) (N- heparan sulfate sulfotransferase 1) (N-HSST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.-.-.-); Heparan sulfate N- sulfotransferase 1 (EC 2.8.2.-)].

RNF12_HUMAN
NC score	0.010848 (rank : 57)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	87	Target Neighborhood Hits	173	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

LYN_HUMAN
NC score	0.010617 (rank : 58)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	87	Target Neighborhood Hits	1022	Shared Neighborhood Hits	26
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SAS6_MOUSE
NC score	0.009991 (rank : 59)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	87	Target Neighborhood Hits	931	Shared Neighborhood Hits	9
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

IMPG1_MOUSE
NC score	0.009988 (rank : 60)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	87	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R1W8, Q9CTP8, Q9ES62, Q9ET31	Gene names	Impg1, Spacr
Domain Architecture	No domain graphic available
Description	Interphotoreceptor matrix proteoglycan 1 precursor (IPM 150 proteoglycan) (Sialoprotein associated with cones and rods).

MYO15_MOUSE
NC score	0.009832 (rank : 61)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	87	Target Neighborhood Hits	467	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

AL2SB_HUMAN
NC score	0.009096 (rank : 62)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	87	Target Neighborhood Hits	294	Shared Neighborhood Hits	9
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

AT131_MOUSE
NC score	0.009061 (rank : 63)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	87	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPE9	Gene names	Atp13a1, Atp13a
Domain Architecture
Description	Probable cation-transporting ATPase 13A1 (EC 3.6.3.-) (CATP).

AT131_HUMAN
NC score	0.008986 (rank : 64)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	87	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HD20, Q9H6C6	Gene names	ATP13A1, ATP13A, KIAA1825
Domain Architecture
Description	Probable cation-transporting ATPase 13A1 (EC 3.6.3.-).

APC_HUMAN
NC score	0.008926 (rank : 65)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	87	Target Neighborhood Hits	603	Shared Neighborhood Hits	12
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

CP11A_MOUSE
NC score	0.008345 (rank : 66)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	87	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QZ82	Gene names	Cyp11a1, Cyp11a
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

SYNP2_MOUSE
NC score	0.007900 (rank : 67)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	87	Target Neighborhood Hits	252	Shared Neighborhood Hits	14
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

RHPN1_MOUSE
NC score	0.007643 (rank : 68)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	87	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

IRK4_MOUSE
NC score	0.007283 (rank : 69)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	87	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	P52189	Gene names	Kcnj4, Irk3
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (IRK3).

IRK4_HUMAN
NC score	0.007280 (rank : 70)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	87	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	P48050	Gene names	KCNJ4
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2).

EHMT2_MOUSE
NC score	0.007163 (rank : 71)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	87	Target Neighborhood Hits	750	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

GP115_HUMAN
NC score	0.007157 (rank : 72)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IZF3, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6	Gene names	GPR115, PGR18
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 115 (G-protein coupled receptor PGR18).

ANK2_HUMAN
NC score	0.006920 (rank : 73)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	87	Target Neighborhood Hits	1615	Shared Neighborhood Hits	29
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

BUB1B_HUMAN
NC score	0.006894 (rank : 74)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	87	Target Neighborhood Hits	208	Shared Neighborhood Hits	7
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

NUMA1_HUMAN
NC score	0.005548 (rank : 75)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	87	Target Neighborhood Hits	1523	Shared Neighborhood Hits	16
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RRBP1_MOUSE
NC score	0.005081 (rank : 76)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	87	Target Neighborhood Hits	1650	Shared Neighborhood Hits	19
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

TTLL5_HUMAN
NC score	0.004879 (rank : 77)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	87	Target Neighborhood Hits	141	Shared Neighborhood Hits	5
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

S6A14_MOUSE
NC score	0.004271 (rank : 78)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	87	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMA9, Q91Y60, Q9D317, Q9R183	Gene names	Slc6a14
Domain Architecture
Description	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Colonic system B0+ amino acid transporter CATB0+) (Solute carrier family 6 member 14).

FOXC2_HUMAN
NC score	0.004024 (rank : 79)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	87	Target Neighborhood Hits	236	Shared Neighborhood Hits	10
SwissProt Accessions	Q99958	Gene names	FOXC2, FKHL14, MFH1
Domain Architecture
Description	Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14).

PTN14_HUMAN
NC score	0.003519 (rank : 80)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	87	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

SEPT9_HUMAN
NC score	0.003498 (rank : 81)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	87	Target Neighborhood Hits	706	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

TLR4_HUMAN
NC score	0.003095 (rank : 82)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	87	Target Neighborhood Hits	298	Shared Neighborhood Hits	4
SwissProt Accessions	O00206, Q9UK78, Q9UM57	Gene names	TLR4
Domain Architecture
Description	Toll-like receptor 4 precursor (hToll) (CD284 antigen).

KIF1A_MOUSE
NC score	0.002680 (rank : 83)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	87	Target Neighborhood Hits	239	Shared Neighborhood Hits	4
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

TITIN_HUMAN
NC score	0.002539 (rank : 84)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	87	Target Neighborhood Hits	2923	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

WNK4_MOUSE
NC score	0.002246 (rank : 85)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	87	Target Neighborhood Hits	961	Shared Neighborhood Hits	18
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ULK1_HUMAN
NC score	0.001974 (rank : 86)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	87	Target Neighborhood Hits	1121	Shared Neighborhood Hits	15
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

TLK2_HUMAN
NC score	0.000999 (rank : 87)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	87	Target Neighborhood Hits	1044	Shared Neighborhood Hits	14
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

LRRK2_HUMAN
NC score	-0.000530 (rank : 88)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	87	Target Neighborhood Hits	1382	Shared Neighborhood Hits	11
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).