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Network neighborhood for query Sequence : S40A1_HUMAN

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S40A1_HUMAN
SwissProt Accessions	Q9NP59, Q7Z4F8, Q8IVB2, Q9NRL0	Gene names	SLC40A1, FPN1, IREG1, SLC11A3
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

S40A1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NP59, Q7Z4F8, Q8IVB2, Q9NRL0	Gene names	SLC40A1, FPN1, IREG1, SLC11A3
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1).

S40A1_MOUSE
θ value	0 (rank : 2)	NC score	0.998192 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JHI9, Q3UHZ9, Q8BME5, Q8BUM5, Q9JIM9, Q9JKP4	Gene names	Slc40a1, Fpn1, Ireg1, Slc11a3, Slc39a1
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1).

DOCK3_HUMAN
θ value	1.06291 (rank : 3)	NC score	0.042388 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	1.06291 (rank : 4)	NC score	0.042360 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

IL1R1_HUMAN
θ value	1.81305 (rank : 5)	NC score	0.018610 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	140	Shared Neighborhood Hits	2
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

M3K1_MOUSE
θ value	5.27518 (rank : 6)	NC score	0.004743 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	952	Shared Neighborhood Hits	3
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

HMCS2_HUMAN
θ value	6.88961 (rank : 7)	NC score	0.014609 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	P54868	Gene names	HMGCS2
Domain Architecture
Description	Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

P2RY8_HUMAN
θ value	6.88961 (rank : 8)	NC score	0.010560 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	630	Shared Neighborhood Hits	3
SwissProt Accessions	Q86VZ1	Gene names	P2RY8
Domain Architecture	No domain graphic available
Description	P2Y purinoceptor 8 (P2Y8).

PK3CD_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.008665 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

ENAM_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.014255 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	227	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

Hits sorted by NC score

S40A1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NP59, Q7Z4F8, Q8IVB2, Q9NRL0	Gene names	SLC40A1, FPN1, IREG1, SLC11A3
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1).

S40A1_MOUSE
NC score	0.998192 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JHI9, Q3UHZ9, Q8BME5, Q8BUM5, Q9JIM9, Q9JKP4	Gene names	Slc40a1, Fpn1, Ireg1, Slc11a3, Slc39a1
Domain Architecture
Description	Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1).

DOCK3_HUMAN
NC score	0.042388 (rank : 3)	θ value	1.06291 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
NC score	0.042360 (rank : 4)	θ value	1.06291 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

IL1R1_HUMAN
NC score	0.018610 (rank : 5)	θ value	1.81305 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	140	Shared Neighborhood Hits	2
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

HMCS2_HUMAN
NC score	0.014609 (rank : 6)	θ value	6.88961 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	P54868	Gene names	HMGCS2
Domain Architecture
Description	Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

ENAM_HUMAN
NC score	0.014255 (rank : 7)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	227	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

P2RY8_HUMAN
NC score	0.010560 (rank : 8)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	630	Shared Neighborhood Hits	3
SwissProt Accessions	Q86VZ1	Gene names	P2RY8
Domain Architecture	No domain graphic available
Description	P2Y purinoceptor 8 (P2Y8).

PK3CD_MOUSE
NC score	0.008665 (rank : 9)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

M3K1_MOUSE
NC score	0.004743 (rank : 10)	θ value	5.27518 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	952	Shared Neighborhood Hits	3
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).