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Network neighborhood for query Sequence : DOCK1_HUMAN

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DOCK1_HUMAN
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DOCK1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	191
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DOCK2_HUMAN
θ value	0 (rank : 2)	NC score	0.968881 (rank : 2)
Query Neighborhood Hits	191	Target Neighborhood Hits	90	Shared Neighborhood Hits	54
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
θ value	0 (rank : 3)	NC score	0.964812 (rank : 3)
Query Neighborhood Hits	191	Target Neighborhood Hits	104	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DOCK3_HUMAN
θ value	0 (rank : 4)	NC score	0.946309 (rank : 5)
Query Neighborhood Hits	191	Target Neighborhood Hits	87	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	0 (rank : 5)	NC score	0.946908 (rank : 4)
Query Neighborhood Hits	191	Target Neighborhood Hits	93	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK4_HUMAN
θ value	0 (rank : 6)	NC score	0.935049 (rank : 7)
Query Neighborhood Hits	191	Target Neighborhood Hits	237	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	0 (rank : 7)	NC score	0.936070 (rank : 6)
Query Neighborhood Hits	191	Target Neighborhood Hits	210	Shared Neighborhood Hits	35
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOC10_HUMAN
θ value	8.38298e-14 (rank : 8)	NC score	0.435049 (rank : 8)
Query Neighborhood Hits	191	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DOCK9_MOUSE
θ value	1.133e-10 (rank : 9)	NC score	0.394920 (rank : 9)
Query Neighborhood Hits	191	Target Neighborhood Hits	79	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_HUMAN
θ value	1.9326e-10 (rank : 10)	NC score	0.392638 (rank : 10)
Query Neighborhood Hits	191	Target Neighborhood Hits	82	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK8_MOUSE
θ value	8.11959e-09 (rank : 11)	NC score	0.389259 (rank : 11)
Query Neighborhood Hits	191	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C147, Q6PIS0, Q7TMQ5, Q8K105, Q9DBQ2	Gene names	Dock8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK7_HUMAN
θ value	1.80886e-08 (rank : 12)	NC score	0.377068 (rank : 13)
Query Neighborhood Hits	191	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q96N67, Q6ZV32, Q8TB82, Q96NG6, Q9C092	Gene names	DOCK7, KIAA1771
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 7.

DOCK8_HUMAN
θ value	2.36244e-08 (rank : 13)	NC score	0.381685 (rank : 12)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK6_HUMAN
θ value	4.45536e-07 (rank : 14)	NC score	0.363738 (rank : 14)
Query Neighborhood Hits	191	Target Neighborhood Hits	71	Shared Neighborhood Hits	15
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

M3KL4_HUMAN
θ value	0.000158464 (rank : 15)	NC score	0.064705 (rank : 154)
Query Neighborhood Hits	191	Target Neighborhood Hits	1087	Shared Neighborhood Hits	112
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

DNMBP_HUMAN
θ value	0.00020696 (rank : 16)	NC score	0.227782 (rank : 17)
Query Neighborhood Hits	191	Target Neighborhood Hits	413	Shared Neighborhood Hits	134
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	0.000270298 (rank : 17)	NC score	0.217638 (rank : 19)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	133
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRC8_HUMAN
θ value	0.000270298 (rank : 18)	NC score	0.215728 (rank : 20)
Query Neighborhood Hits	191	Target Neighborhood Hits	269	Shared Neighborhood Hits	115
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

CD2AP_MOUSE
θ value	0.00035302 (rank : 19)	NC score	0.209453 (rank : 26)
Query Neighborhood Hits	191	Target Neighborhood Hits	336	Shared Neighborhood Hits	121
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

M3K9_HUMAN
θ value	0.00035302 (rank : 20)	NC score	0.065583 (rank : 149)
Query Neighborhood Hits	191	Target Neighborhood Hits	1123	Shared Neighborhood Hits	115
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SRC8_MOUSE
θ value	0.00035302 (rank : 21)	NC score	0.214674 (rank : 22)
Query Neighborhood Hits	191	Target Neighborhood Hits	292	Shared Neighborhood Hits	117
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

HCLS1_HUMAN
θ value	0.000461057 (rank : 22)	NC score	0.224287 (rank : 18)
Query Neighborhood Hits	191	Target Neighborhood Hits	358	Shared Neighborhood Hits	111
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

FRK_HUMAN
θ value	0.000786445 (rank : 23)	NC score	0.054874 (rank : 187)
Query Neighborhood Hits	191	Target Neighborhood Hits	1058	Shared Neighborhood Hits	104
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HCLS1_MOUSE
θ value	0.00228821 (rank : 24)	NC score	0.210690 (rank : 25)
Query Neighborhood Hits	191	Target Neighborhood Hits	329	Shared Neighborhood Hits	111
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

MYO1E_HUMAN
θ value	0.00298849 (rank : 25)	NC score	0.082359 (rank : 122)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	112
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

CD2AP_HUMAN
θ value	0.00390308 (rank : 26)	NC score	0.211510 (rank : 24)
Query Neighborhood Hits	191	Target Neighborhood Hits	315	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

LYN_HUMAN
θ value	0.00509761 (rank : 27)	NC score	0.061003 (rank : 165)
Query Neighborhood Hits	191	Target Neighborhood Hits	1022	Shared Neighborhood Hits	105
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

HCK_MOUSE
θ value	0.00665767 (rank : 28)	NC score	0.061349 (rank : 164)
Query Neighborhood Hits	191	Target Neighborhood Hits	1029	Shared Neighborhood Hits	107
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

LYN_MOUSE
θ value	0.00665767 (rank : 29)	NC score	0.061437 (rank : 163)
Query Neighborhood Hits	191	Target Neighborhood Hits	1023	Shared Neighborhood Hits	105
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PPIP1_HUMAN
θ value	0.00665767 (rank : 30)	NC score	0.168147 (rank : 37)
Query Neighborhood Hits	191	Target Neighborhood Hits	389	Shared Neighborhood Hits	124
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

DDEF2_MOUSE
θ value	0.00869519 (rank : 31)	NC score	0.094640 (rank : 106)
Query Neighborhood Hits	191	Target Neighborhood Hits	625	Shared Neighborhood Hits	97
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ITSN1_MOUSE
θ value	0.00869519 (rank : 32)	NC score	0.133608 (rank : 63)
Query Neighborhood Hits	191	Target Neighborhood Hits	1669	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ABI2_HUMAN
θ value	0.0113563 (rank : 33)	NC score	0.180824 (rank : 29)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	116
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ARHGG_MOUSE
θ value	0.0113563 (rank : 34)	NC score	0.081819 (rank : 124)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGR_HUMAN
θ value	0.0113563 (rank : 35)	NC score	0.063238 (rank : 158)
Query Neighborhood Hits	191	Target Neighborhood Hits	1067	Shared Neighborhood Hits	105
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ITSN1_HUMAN
θ value	0.0113563 (rank : 36)	NC score	0.131802 (rank : 70)
Query Neighborhood Hits	191	Target Neighborhood Hits	1757	Shared Neighborhood Hits	144
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

LASP1_HUMAN
θ value	0.0113563 (rank : 37)	NC score	0.163874 (rank : 40)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	109
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.0113563 (rank : 38)	NC score	0.163265 (rank : 41)
Query Neighborhood Hits	191	Target Neighborhood Hits	297	Shared Neighborhood Hits	109
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PPIP1_MOUSE
θ value	0.0113563 (rank : 39)	NC score	0.165801 (rank : 39)
Query Neighborhood Hits	191	Target Neighborhood Hits	377	Shared Neighborhood Hits	121
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ABI2_MOUSE
θ value	0.0148317 (rank : 40)	NC score	0.177184 (rank : 30)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	114
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

BCL9_HUMAN
θ value	0.0148317 (rank : 41)	NC score	0.028249 (rank : 211)
Query Neighborhood Hits	191	Target Neighborhood Hits	1008	Shared Neighborhood Hits	21
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

MYO1F_MOUSE
θ value	0.0148317 (rank : 42)	NC score	0.083214 (rank : 120)
Query Neighborhood Hits	191	Target Neighborhood Hits	262	Shared Neighborhood Hits	114
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SRBS1_HUMAN
θ value	0.0148317 (rank : 43)	NC score	0.214738 (rank : 21)
Query Neighborhood Hits	191	Target Neighborhood Hits	396	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MYO1F_HUMAN
θ value	0.0193708 (rank : 44)	NC score	0.082568 (rank : 121)
Query Neighborhood Hits	191	Target Neighborhood Hits	275	Shared Neighborhood Hits	115
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SH3K1_HUMAN
θ value	0.0193708 (rank : 45)	NC score	0.183458 (rank : 28)
Query Neighborhood Hits	191	Target Neighborhood Hits	341	Shared Neighborhood Hits	120
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0.0193708 (rank : 46)	NC score	0.183618 (rank : 27)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_MOUSE
θ value	0.0193708 (rank : 47)	NC score	0.212398 (rank : 23)
Query Neighborhood Hits	191	Target Neighborhood Hits	409	Shared Neighborhood Hits	123
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
θ value	0.0193708 (rank : 48)	NC score	0.236457 (rank : 15)
Query Neighborhood Hits	191	Target Neighborhood Hits	270	Shared Neighborhood Hits	123
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	0.0193708 (rank : 49)	NC score	0.236445 (rank : 16)
Query Neighborhood Hits	191	Target Neighborhood Hits	286	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

JIP2_HUMAN
θ value	0.0252991 (rank : 50)	NC score	0.092889 (rank : 107)
Query Neighborhood Hits	191	Target Neighborhood Hits	288	Shared Neighborhood Hits	52
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.0252991 (rank : 51)	NC score	0.096034 (rank : 104)
Query Neighborhood Hits	191	Target Neighborhood Hits	144	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

NEBU_HUMAN
θ value	0.0252991 (rank : 52)	NC score	0.133160 (rank : 65)
Query Neighborhood Hits	191	Target Neighborhood Hits	420	Shared Neighborhood Hits	110
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

PTK6_MOUSE
θ value	0.0252991 (rank : 53)	NC score	0.048554 (rank : 197)
Query Neighborhood Hits	191	Target Neighborhood Hits	1026	Shared Neighborhood Hits	94
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

VAV2_HUMAN
θ value	0.0252991 (rank : 54)	NC score	0.140338 (rank : 59)
Query Neighborhood Hits	191	Target Neighborhood Hits	453	Shared Neighborhood Hits	119
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ABI1_HUMAN
θ value	0.0330416 (rank : 55)	NC score	0.171922 (rank : 35)
Query Neighborhood Hits	191	Target Neighborhood Hits	257	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

AHI1_MOUSE
θ value	0.0330416 (rank : 56)	NC score	0.130542 (rank : 71)
Query Neighborhood Hits	191	Target Neighborhood Hits	496	Shared Neighborhood Hits	119
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

HCK_HUMAN
θ value	0.0330416 (rank : 57)	NC score	0.058327 (rank : 178)
Query Neighborhood Hits	191	Target Neighborhood Hits	1035	Shared Neighborhood Hits	105
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

VAV2_MOUSE
θ value	0.0330416 (rank : 58)	NC score	0.137886 (rank : 60)
Query Neighborhood Hits	191	Target Neighborhood Hits	456	Shared Neighborhood Hits	118
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

GRAP2_HUMAN
θ value	0.0431538 (rank : 59)	NC score	0.172446 (rank : 34)
Query Neighborhood Hits	191	Target Neighborhood Hits	304	Shared Neighborhood Hits	112
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	0.0431538 (rank : 60)	NC score	0.171356 (rank : 36)
Query Neighborhood Hits	191	Target Neighborhood Hits	297	Shared Neighborhood Hits	113
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

M3K10_HUMAN
θ value	0.0431538 (rank : 61)	NC score	0.055927 (rank : 185)
Query Neighborhood Hits	191	Target Neighborhood Hits	1071	Shared Neighborhood Hits	109
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	0.0431538 (rank : 62)	NC score	0.056197 (rank : 183)
Query Neighborhood Hits	191	Target Neighborhood Hits	1136	Shared Neighborhood Hits	110
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NEBL_HUMAN
θ value	0.0431538 (rank : 63)	NC score	0.145706 (rank : 55)
Query Neighborhood Hits	191	Target Neighborhood Hits	457	Shared Neighborhood Hits	118
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PACN1_HUMAN
θ value	0.0431538 (rank : 64)	NC score	0.157595 (rank : 45)
Query Neighborhood Hits	191	Target Neighborhood Hits	320	Shared Neighborhood Hits	118
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.0431538 (rank : 65)	NC score	0.158364 (rank : 44)
Query Neighborhood Hits	191	Target Neighborhood Hits	283	Shared Neighborhood Hits	116
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

DDEF2_HUMAN
θ value	0.0563607 (rank : 66)	NC score	0.090054 (rank : 112)
Query Neighborhood Hits	191	Target Neighborhood Hits	599	Shared Neighborhood Hits	101
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP_HUMAN
θ value	0.0563607 (rank : 67)	NC score	0.173536 (rank : 33)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	118
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	0.0563607 (rank : 68)	NC score	0.176848 (rank : 31)
Query Neighborhood Hits	191	Target Neighborhood Hits	309	Shared Neighborhood Hits	119
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SLC2B_HUMAN
θ value	0.0563607 (rank : 69)	NC score	0.042660 (rank : 202)
Query Neighborhood Hits	191	Target Neighborhood Hits	214	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

ABI1_MOUSE
θ value	0.0736092 (rank : 70)	NC score	0.173902 (rank : 32)
Query Neighborhood Hits	191	Target Neighborhood Hits	246	Shared Neighborhood Hits	110
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

BIN3_HUMAN
θ value	0.0736092 (rank : 71)	NC score	0.058941 (rank : 177)
Query Neighborhood Hits	191	Target Neighborhood Hits	95	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQY0, Q9BVG2, Q9NVY9	Gene names	BIN3
Domain Architecture
Description	Bridging integrator 3.

FYN_HUMAN
θ value	0.0961366 (rank : 72)	NC score	0.060949 (rank : 166)
Query Neighborhood Hits	191	Target Neighborhood Hits	1078	Shared Neighborhood Hits	109
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.0961366 (rank : 73)	NC score	0.061902 (rank : 161)
Query Neighborhood Hits	191	Target Neighborhood Hits	1073	Shared Neighborhood Hits	109
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

OSTF1_HUMAN
θ value	0.0961366 (rank : 74)	NC score	0.128376 (rank : 75)
Query Neighborhood Hits	191	Target Neighborhood Hits	466	Shared Neighborhood Hits	114
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

VAV_HUMAN
θ value	0.0961366 (rank : 75)	NC score	0.133531 (rank : 64)
Query Neighborhood Hits	191	Target Neighborhood Hits	452	Shared Neighborhood Hits	116
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

AHI1_HUMAN
θ value	0.125558 (rank : 76)	NC score	0.128370 (rank : 76)
Query Neighborhood Hits	191	Target Neighborhood Hits	537	Shared Neighborhood Hits	116
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

FGR_MOUSE
θ value	0.125558 (rank : 77)	NC score	0.060509 (rank : 169)
Query Neighborhood Hits	191	Target Neighborhood Hits	1069	Shared Neighborhood Hits	106
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ITSN2_HUMAN
θ value	0.125558 (rank : 78)	NC score	0.119898 (rank : 87)
Query Neighborhood Hits	191	Target Neighborhood Hits	1173	Shared Neighborhood Hits	128
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	0.125558 (rank : 79)	NC score	0.115577 (rank : 93)
Query Neighborhood Hits	191	Target Neighborhood Hits	1371	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JIP1_HUMAN
θ value	0.125558 (rank : 80)	NC score	0.076081 (rank : 128)
Query Neighborhood Hits	191	Target Neighborhood Hits	271	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SPTA1_MOUSE
θ value	0.125558 (rank : 81)	NC score	0.063109 (rank : 159)
Query Neighborhood Hits	191	Target Neighborhood Hits	675	Shared Neighborhood Hits	106
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

YES_HUMAN
θ value	0.125558 (rank : 82)	NC score	0.060249 (rank : 172)
Query Neighborhood Hits	191	Target Neighborhood Hits	1059	Shared Neighborhood Hits	102
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHG7_HUMAN
θ value	0.163984 (rank : 83)	NC score	0.141570 (rank : 58)
Query Neighborhood Hits	191	Target Neighborhood Hits	347	Shared Neighborhood Hits	120
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	0.163984 (rank : 84)	NC score	0.145893 (rank : 54)
Query Neighborhood Hits	191	Target Neighborhood Hits	396	Shared Neighborhood Hits	124
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

OSTF1_MOUSE
θ value	0.163984 (rank : 85)	NC score	0.125652 (rank : 77)
Query Neighborhood Hits	191	Target Neighborhood Hits	467	Shared Neighborhood Hits	115
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

YES_MOUSE
θ value	0.163984 (rank : 86)	NC score	0.060402 (rank : 171)
Query Neighborhood Hits	191	Target Neighborhood Hits	1052	Shared Neighborhood Hits	102
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

GRB2_HUMAN
θ value	0.21417 (rank : 87)	NC score	0.160955 (rank : 42)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	113
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.21417 (rank : 88)	NC score	0.160766 (rank : 43)
Query Neighborhood Hits	191	Target Neighborhood Hits	312	Shared Neighborhood Hits	113
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

JIP1_MOUSE
θ value	0.21417 (rank : 89)	NC score	0.074852 (rank : 129)
Query Neighborhood Hits	191	Target Neighborhood Hits	259	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

VAV_MOUSE
θ value	0.21417 (rank : 90)	NC score	0.132714 (rank : 67)
Query Neighborhood Hits	191	Target Neighborhood Hits	430	Shared Neighborhood Hits	118
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CTR9_MOUSE
θ value	0.279714 (rank : 91)	NC score	0.031783 (rank : 209)
Query Neighborhood Hits	191	Target Neighborhood Hits	427	Shared Neighborhood Hits	13
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

K0423_HUMAN
θ value	0.279714 (rank : 92)	NC score	0.037772 (rank : 207)
Query Neighborhood Hits	191	Target Neighborhood Hits	171	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y4F4, Q68D66, Q6PG27	Gene names	KIAA0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

CTR9_HUMAN
θ value	0.365318 (rank : 93)	NC score	0.031503 (rank : 210)
Query Neighborhood Hits	191	Target Neighborhood Hits	383	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PD62, Q15015	Gene names	CTR9, KIAA0155, SH2BP1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1).

DBNL_HUMAN
θ value	0.365318 (rank : 94)	NC score	0.147175 (rank : 53)
Query Neighborhood Hits	191	Target Neighborhood Hits	244	Shared Neighborhood Hits	99
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.365318 (rank : 95)	NC score	0.145403 (rank : 56)
Query Neighborhood Hits	191	Target Neighborhood Hits	306	Shared Neighborhood Hits	100
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

KNTC2_MOUSE
θ value	0.365318 (rank : 96)	NC score	0.014654 (rank : 224)
Query Neighborhood Hits	191	Target Neighborhood Hits	692	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

DDEF1_MOUSE
θ value	0.47712 (rank : 97)	NC score	0.091856 (rank : 108)
Query Neighborhood Hits	191	Target Neighborhood Hits	592	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MYO15_MOUSE
θ value	0.47712 (rank : 98)	NC score	0.026813 (rank : 212)
Query Neighborhood Hits	191	Target Neighborhood Hits	467	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

BIN3_MOUSE
θ value	0.62314 (rank : 99)	NC score	0.048379 (rank : 198)
Query Neighborhood Hits	191	Target Neighborhood Hits	165	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JI08	Gene names	Bin3
Domain Architecture	No domain graphic available
Description	Bridging integrator 3.

LRC18_HUMAN
θ value	0.62314 (rank : 100)	NC score	0.009519 (rank : 243)
Query Neighborhood Hits	191	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N456, Q6UY02	Gene names	LRRC18
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 18.

NGEF_MOUSE
θ value	0.62314 (rank : 101)	NC score	0.080290 (rank : 125)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PACN2_HUMAN
θ value	0.62314 (rank : 102)	NC score	0.150101 (rank : 48)
Query Neighborhood Hits	191	Target Neighborhood Hits	339	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	0.62314 (rank : 103)	NC score	0.152174 (rank : 46)
Query Neighborhood Hits	191	Target Neighborhood Hits	382	Shared Neighborhood Hits	121
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

VAV3_HUMAN
θ value	0.62314 (rank : 104)	NC score	0.120982 (rank : 82)
Query Neighborhood Hits	191	Target Neighborhood Hits	398	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

BTK_HUMAN
θ value	0.813845 (rank : 105)	NC score	0.051367 (rank : 195)
Query Neighborhood Hits	191	Target Neighborhood Hits	1026	Shared Neighborhood Hits	103
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

INGR1_MOUSE
θ value	0.813845 (rank : 106)	NC score	0.025560 (rank : 214)
Query Neighborhood Hits	191	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	P15261	Gene names	Ifngr1, Ifngr
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen).

PACN3_HUMAN
θ value	0.813845 (rank : 107)	NC score	0.148080 (rank : 51)
Query Neighborhood Hits	191	Target Neighborhood Hits	385	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.813845 (rank : 108)	NC score	0.148568 (rank : 50)
Query Neighborhood Hits	191	Target Neighborhood Hits	380	Shared Neighborhood Hits	116
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SNX18_MOUSE
θ value	0.813845 (rank : 109)	NC score	0.103644 (rank : 99)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	84
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

VAV3_MOUSE
θ value	0.813845 (rank : 110)	NC score	0.118835 (rank : 89)
Query Neighborhood Hits	191	Target Neighborhood Hits	404	Shared Neighborhood Hits	113
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARAF_HUMAN
θ value	1.06291 (rank : 111)	NC score	0.025177 (rank : 215)
Query Neighborhood Hits	191	Target Neighborhood Hits	924	Shared Neighborhood Hits	34
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARHGG_HUMAN
θ value	1.06291 (rank : 112)	NC score	0.064915 (rank : 153)
Query Neighborhood Hits	191	Target Neighborhood Hits	129	Shared Neighborhood Hits	42
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

COHA1_HUMAN
θ value	1.06291 (rank : 113)	NC score	0.010243 (rank : 236)
Query Neighborhood Hits	191	Target Neighborhood Hits	400	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

NCK1_HUMAN
θ value	1.06291 (rank : 114)	NC score	0.151015 (rank : 47)
Query Neighborhood Hits	191	Target Neighborhood Hits	312	Shared Neighborhood Hits	116
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

STAC3_HUMAN
θ value	1.06291 (rank : 115)	NC score	0.136508 (rank : 61)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	100
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	1.06291 (rank : 116)	NC score	0.136322 (rank : 62)
Query Neighborhood Hits	191	Target Neighborhood Hits	232	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

KTN1_MOUSE
θ value	1.38821 (rank : 117)	NC score	0.014017 (rank : 225)
Query Neighborhood Hits	191	Target Neighborhood Hits	1324	Shared Neighborhood Hits	32
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

SNX18_HUMAN
θ value	1.38821 (rank : 118)	NC score	0.107844 (rank : 98)
Query Neighborhood Hits	191	Target Neighborhood Hits	207	Shared Neighborhood Hits	90
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

BTK_MOUSE
θ value	1.81305 (rank : 119)	NC score	0.049857 (rank : 196)
Query Neighborhood Hits	191	Target Neighborhood Hits	1017	Shared Neighborhood Hits	101
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CCNB1_MOUSE
θ value	1.81305 (rank : 120)	NC score	0.010229 (rank : 237)
Query Neighborhood Hits	191	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	P24860	Gene names	Ccnb1, Ccn-2, Ccnb1-rs13, Cycb, Cycb1
Domain Architecture
Description	G2/mitotic-specific cyclin-B1.

CSK_HUMAN
θ value	1.81305 (rank : 121)	NC score	0.047895 (rank : 199)
Query Neighborhood Hits	191	Target Neighborhood Hits	1009	Shared Neighborhood Hits	95
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	1.81305 (rank : 122)	NC score	0.047826 (rank : 200)
Query Neighborhood Hits	191	Target Neighborhood Hits	1009	Shared Neighborhood Hits	95
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

ES8L2_HUMAN
θ value	1.81305 (rank : 123)	NC score	0.066265 (rank : 147)
Query Neighborhood Hits	191	Target Neighborhood Hits	193	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	1.81305 (rank : 124)	NC score	0.066829 (rank : 145)
Query Neighborhood Hits	191	Target Neighborhood Hits	169	Shared Neighborhood Hits	79
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

NCOA2_HUMAN
θ value	1.81305 (rank : 125)	NC score	0.010136 (rank : 238)
Query Neighborhood Hits	191	Target Neighborhood Hits	281	Shared Neighborhood Hits	9
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

RYR2_HUMAN
θ value	1.81305 (rank : 126)	NC score	0.010551 (rank : 235)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

STAC_MOUSE
θ value	1.81305 (rank : 127)	NC score	0.149275 (rank : 49)
Query Neighborhood Hits	191	Target Neighborhood Hits	268	Shared Neighborhood Hits	114
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TBCD4_HUMAN
θ value	1.81305 (rank : 128)	NC score	0.010061 (rank : 239)
Query Neighborhood Hits	191	Target Neighborhood Hits	357	Shared Neighborhood Hits	8
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

ZEP1_HUMAN
θ value	1.81305 (rank : 129)	NC score	0.001704 (rank : 255)
Query Neighborhood Hits	191	Target Neighborhood Hits	1036	Shared Neighborhood Hits	12
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

ZN277_HUMAN
θ value	1.81305 (rank : 130)	NC score	0.023585 (rank : 217)
Query Neighborhood Hits	191	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRM2	Gene names	ZNF277
Domain Architecture	No domain graphic available
Description	Zinc finger protein 277.

ARHG6_HUMAN
θ value	2.36792 (rank : 131)	NC score	0.133154 (rank : 66)
Query Neighborhood Hits	191	Target Neighborhood Hits	376	Shared Neighborhood Hits	120
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	2.36792 (rank : 132)	NC score	0.132149 (rank : 68)
Query Neighborhood Hits	191	Target Neighborhood Hits	394	Shared Neighborhood Hits	116
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARI5B_HUMAN
θ value	2.36792 (rank : 133)	NC score	0.013752 (rank : 226)
Query Neighborhood Hits	191	Target Neighborhood Hits	328	Shared Neighborhood Hits	8
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

KTN1_HUMAN
θ value	2.36792 (rank : 134)	NC score	0.009903 (rank : 240)
Query Neighborhood Hits	191	Target Neighborhood Hits	1197	Shared Neighborhood Hits	22
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

NOXO1_MOUSE
θ value	2.36792 (rank : 135)	NC score	0.095436 (rank : 105)
Query Neighborhood Hits	191	Target Neighborhood Hits	114	Shared Neighborhood Hits	71
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SPRL1_HUMAN
θ value	2.36792 (rank : 136)	NC score	0.011262 (rank : 232)
Query Neighborhood Hits	191	Target Neighborhood Hits	231	Shared Neighborhood Hits	6
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

TCGAP_HUMAN
θ value	2.36792 (rank : 137)	NC score	0.053673 (rank : 189)
Query Neighborhood Hits	191	Target Neighborhood Hits	872	Shared Neighborhood Hits	86
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	2.36792 (rank : 138)	NC score	0.059683 (rank : 176)
Query Neighborhood Hits	191	Target Neighborhood Hits	409	Shared Neighborhood Hits	83
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ADX_HUMAN
θ value	3.0926 (rank : 139)	NC score	0.020526 (rank : 219)
Query Neighborhood Hits	191	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P10109, Q53YD6	Gene names	FDX1, ADX
Domain Architecture
Description	Adrenodoxin, mitochondrial precursor (Adrenal ferredoxin) (Ferredoxin- 1) (Hepatoredoxin).

APOB_HUMAN
θ value	3.0926 (rank : 140)	NC score	0.042139 (rank : 203)
Query Neighborhood Hits	191	Target Neighborhood Hits	202	Shared Neighborhood Hits	13
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

BPAEA_HUMAN
θ value	3.0926 (rank : 141)	NC score	0.013290 (rank : 229)
Query Neighborhood Hits	191	Target Neighborhood Hits	1369	Shared Neighborhood Hits	31
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CP4FB_HUMAN
θ value	3.0926 (rank : 142)	NC score	0.002667 (rank : 252)
Query Neighborhood Hits	191	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBI6, O75254, Q96AQ5	Gene names	CYP4F11
Domain Architecture
Description	Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11).

MACF1_HUMAN
θ value	3.0926 (rank : 143)	NC score	0.015941 (rank : 221)
Query Neighborhood Hits	191	Target Neighborhood Hits	1341	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	3.0926 (rank : 144)	NC score	0.013201 (rank : 230)
Query Neighborhood Hits	191	Target Neighborhood Hits	1321	Shared Neighborhood Hits	31
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

NCOA6_HUMAN
θ value	3.0926 (rank : 145)	NC score	0.036447 (rank : 208)
Query Neighborhood Hits	191	Target Neighborhood Hits	1202	Shared Neighborhood Hits	29
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PYGO2_HUMAN
θ value	3.0926 (rank : 146)	NC score	0.016753 (rank : 220)
Query Neighborhood Hits	191	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

RHG04_HUMAN
θ value	3.0926 (rank : 147)	NC score	0.077679 (rank : 127)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	95
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RRFM_HUMAN
θ value	3.0926 (rank : 148)	NC score	0.024323 (rank : 216)
Query Neighborhood Hits	191	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q96E11, Q5RKT1, Q5T7T0, Q5T7T1, Q5T7T2, Q5T7T3, Q5T7T4, Q5T7T5	Gene names	MRRF
Domain Architecture	No domain graphic available
Description	Ribosome recycling factor, mitochondrial precursor.

SNX9_HUMAN
θ value	3.0926 (rank : 149)	NC score	0.067055 (rank : 144)
Query Neighborhood Hits	191	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	3.0926 (rank : 150)	NC score	0.056064 (rank : 184)
Query Neighborhood Hits	191	Target Neighborhood Hits	141	Shared Neighborhood Hits	53
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SRGP2_MOUSE
θ value	3.0926 (rank : 151)	NC score	0.065503 (rank : 150)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	92
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC_HUMAN
θ value	3.0926 (rank : 152)	NC score	0.147208 (rank : 52)
Query Neighborhood Hits	191	Target Neighborhood Hits	276	Shared Neighborhood Hits	113
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CASL_MOUSE
θ value	4.03905 (rank : 153)	NC score	0.078871 (rank : 126)
Query Neighborhood Hits	191	Target Neighborhood Hits	225	Shared Neighborhood Hits	94
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CEP70_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.012300 (rank : 231)
Query Neighborhood Hits	191	Target Neighborhood Hits	432	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

FUT8_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.039869 (rank : 206)
Query Neighborhood Hits	191	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

HUCE1_MOUSE
θ value	4.03905 (rank : 156)	NC score	0.013668 (rank : 227)
Query Neighborhood Hits	191	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DB85, Q8BHW3	Gene names
Domain Architecture	No domain graphic available
Description	Cerebral protein 1 homolog.

NCF2_HUMAN
θ value	4.03905 (rank : 157)	NC score	0.167361 (rank : 38)
Query Neighborhood Hits	191	Target Neighborhood Hits	229	Shared Neighborhood Hits	108
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

RRFM_MOUSE
θ value	4.03905 (rank : 158)	NC score	0.022001 (rank : 218)
Query Neighborhood Hits	191	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D6S7	Gene names	Mrrf
Domain Architecture	No domain graphic available
Description	Ribosome recycling factor, mitochondrial precursor.

ZN435_HUMAN
θ value	4.03905 (rank : 159)	NC score	-0.003990 (rank : 258)
Query Neighborhood Hits	191	Target Neighborhood Hits	774	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H4T2, Q9H6K2	Gene names	ZNF435, ZSCAN16
Domain Architecture
Description	Zinc finger protein 435 (Zinc finger and SCAN domain-containing protein 16).

CRSP7_HUMAN
θ value	5.27518 (rank : 160)	NC score	0.013412 (rank : 228)
Query Neighborhood Hits	191	Target Neighborhood Hits	247	Shared Neighborhood Hits	10
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

GOGA4_MOUSE
θ value	5.27518 (rank : 161)	NC score	0.007499 (rank : 246)
Query Neighborhood Hits	191	Target Neighborhood Hits	1939	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

K0423_MOUSE
θ value	5.27518 (rank : 162)	NC score	0.025978 (rank : 213)
Query Neighborhood Hits	191	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

PEX13_MOUSE
θ value	5.27518 (rank : 163)	NC score	0.090798 (rank : 109)
Query Neighborhood Hits	191	Target Neighborhood Hits	126	Shared Neighborhood Hits	77
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RTEL1_HUMAN
θ value	5.27518 (rank : 164)	NC score	0.009055 (rank : 244)
Query Neighborhood Hits	191	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

SRGP2_HUMAN
θ value	5.27518 (rank : 165)	NC score	0.064172 (rank : 157)
Query Neighborhood Hits	191	Target Neighborhood Hits	331	Shared Neighborhood Hits	91
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRMS_MOUSE
θ value	5.27518 (rank : 166)	NC score	0.040258 (rank : 205)
Query Neighborhood Hits	191	Target Neighborhood Hits	964	Shared Neighborhood Hits	73
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ZBED1_HUMAN
θ value	5.27518 (rank : 167)	NC score	0.014836 (rank : 223)
Query Neighborhood Hits	191	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O96006, Q96BY4	Gene names	ZBED1, ALTE, DREF, KIAA0785, TRAMP
Domain Architecture
Description	Zinc finger BED domain-containing protein 1 (dREF homolog) (Putative Ac-like transposable element).

ANGP2_MOUSE
θ value	6.88961 (rank : 168)	NC score	0.003863 (rank : 249)
Query Neighborhood Hits	191	Target Neighborhood Hits	397	Shared Neighborhood Hits	15
SwissProt Accessions	O35608, Q3U1A1, Q9D2D2	Gene names	Angpt2, Agpt2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

CD2_HUMAN
θ value	6.88961 (rank : 169)	NC score	0.009836 (rank : 242)
Query Neighborhood Hits	191	Target Neighborhood Hits	504	Shared Neighborhood Hits	14
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CI082_MOUSE
θ value	6.88961 (rank : 170)	NC score	0.010909 (rank : 234)
Query Neighborhood Hits	191	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDY9	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf82 homolog.

FLIP1_HUMAN
θ value	6.88961 (rank : 171)	NC score	0.008951 (rank : 245)
Query Neighborhood Hits	191	Target Neighborhood Hits	1405	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

PLCG2_HUMAN
θ value	6.88961 (rank : 172)	NC score	0.100045 (rank : 102)
Query Neighborhood Hits	191	Target Neighborhood Hits	280	Shared Neighborhood Hits	104
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PTK6_HUMAN
θ value	6.88961 (rank : 173)	NC score	0.043825 (rank : 201)
Query Neighborhood Hits	191	Target Neighborhood Hits	1020	Shared Neighborhood Hits	94
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

RBL2_HUMAN
θ value	6.88961 (rank : 174)	NC score	0.005979 (rank : 247)
Query Neighborhood Hits	191	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q08999, Q15073, Q16084, Q92812	Gene names	RBL2, RB2
Domain Architecture
Description	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).

SH3G2_MOUSE
θ value	6.88961 (rank : 175)	NC score	0.120250 (rank : 85)
Query Neighborhood Hits	191	Target Neighborhood Hits	319	Shared Neighborhood Hits	110
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SYNE1_HUMAN
θ value	6.88961 (rank : 176)	NC score	0.009865 (rank : 241)
Query Neighborhood Hits	191	Target Neighborhood Hits	1484	Shared Neighborhood Hits	37
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ASPP1_MOUSE
θ value	8.99809 (rank : 177)	NC score	0.061509 (rank : 162)
Query Neighborhood Hits	191	Target Neighborhood Hits	1244	Shared Neighborhood Hits	119
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAI2_HUMAN
θ value	8.99809 (rank : 178)	NC score	0.000503 (rank : 256)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BIN1_HUMAN
θ value	8.99809 (rank : 179)	NC score	0.053417 (rank : 190)
Query Neighborhood Hits	191	Target Neighborhood Hits	335	Shared Neighborhood Hits	60
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	8.99809 (rank : 180)	NC score	0.052540 (rank : 191)
Query Neighborhood Hits	191	Target Neighborhood Hits	283	Shared Neighborhood Hits	65
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CNOT4_MOUSE
θ value	8.99809 (rank : 181)	NC score	0.015084 (rank : 222)
Query Neighborhood Hits	191	Target Neighborhood Hits	277	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CO5A3_HUMAN
θ value	8.99809 (rank : 182)	NC score	0.002424 (rank : 254)
Query Neighborhood Hits	191	Target Neighborhood Hits	433	Shared Neighborhood Hits	12
SwissProt Accessions	P25940, Q9NZQ6	Gene names	COL5A3
Domain Architecture
Description	Collagen alpha-3(V) chain precursor.

EPS8_MOUSE
θ value	8.99809 (rank : 183)	NC score	0.055457 (rank : 186)
Query Neighborhood Hits	191	Target Neighborhood Hits	157	Shared Neighborhood Hits	77
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

MILK1_MOUSE
θ value	8.99809 (rank : 184)	NC score	0.011016 (rank : 233)
Query Neighborhood Hits	191	Target Neighborhood Hits	788	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NOXO1_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.065795 (rank : 148)
Query Neighborhood Hits	191	Target Neighborhood Hits	100	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SEPT2_HUMAN
θ value	8.99809 (rank : 186)	NC score	0.003468 (rank : 251)
Query Neighborhood Hits	191	Target Neighborhood Hits	101	Shared Neighborhood Hits	3
SwissProt Accessions	Q15019, Q14132, Q8IUK9, Q96CB0	Gene names	SEPT2, DIFF6, KIAA0158, NEDD5
Domain Architecture
Description	Septin-2 (Protein NEDD5).

SEPT2_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.003469 (rank : 250)
Query Neighborhood Hits	191	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	P42208, Q3U9Y5	Gene names	Sept2, Nedd-5, Nedd5
Domain Architecture
Description	Septin-2 (Protein NEDD5) (Neural precursor cell expressed developmentally down-regulated protein 5).

TEC_MOUSE
θ value	8.99809 (rank : 188)	NC score	0.041077 (rank : 204)
Query Neighborhood Hits	191	Target Neighborhood Hits	1006	Shared Neighborhood Hits	92
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TENX_HUMAN
θ value	8.99809 (rank : 189)	NC score	-0.001600 (rank : 257)
Query Neighborhood Hits	191	Target Neighborhood Hits	789	Shared Neighborhood Hits	7
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TP53B_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.005418 (rank : 248)
Query Neighborhood Hits	191	Target Neighborhood Hits	413	Shared Neighborhood Hits	10
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ZHX2_MOUSE
θ value	8.99809 (rank : 191)	NC score	0.002654 (rank : 253)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0C0	Gene names	Zhx2, Afr1, Raf
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

ABI3_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.129221 (rank : 73)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	101
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.129306 (rank : 72)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AMPH_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.057906 (rank : 179)
Query Neighborhood Hits	191	Target Neighborhood Hits	455	Shared Neighborhood Hits	64
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.056978 (rank : 181)
Query Neighborhood Hits	191	Target Neighborhood Hits	291	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.068262 (rank : 141)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	90
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.064236 (rank : 156)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG4_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.090232 (rank : 111)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.070337 (rank : 135)
Query Neighborhood Hits	191	Target Neighborhood Hits	185	Shared Neighborhood Hits	74
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.068927 (rank : 140)
Query Neighborhood Hits	191	Target Neighborhood Hits	172	Shared Neighborhood Hits	68
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG9_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.084043 (rank : 119)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	100
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.084567 (rank : 118)
Query Neighborhood Hits	191	Target Neighborhood Hits	234	Shared Neighborhood Hits	99
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ASPP1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.059703 (rank : 175)
Query Neighborhood Hits	191	Target Neighborhood Hits	956	Shared Neighborhood Hits	113
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.086494 (rank : 116)
Query Neighborhood Hits	191	Target Neighborhood Hits	554	Shared Neighborhood Hits	106
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.087689 (rank : 114)
Query Neighborhood Hits	191	Target Neighborhood Hits	438	Shared Neighborhood Hits	104
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.073908 (rank : 132)
Query Neighborhood Hits	191	Target Neighborhood Hits	259	Shared Neighborhood Hits	95
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CRKL_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.117531 (rank : 91)
Query Neighborhood Hits	191	Target Neighborhood Hits	313	Shared Neighborhood Hits	111
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.115945 (rank : 92)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	109
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.110057 (rank : 97)
Query Neighborhood Hits	191	Target Neighborhood Hits	308	Shared Neighborhood Hits	111
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.112132 (rank : 96)
Query Neighborhood Hits	191	Target Neighborhood Hits	314	Shared Neighborhood Hits	111
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.090666 (rank : 110)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

EFS_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.082296 (rank : 123)
Query Neighborhood Hits	191	Target Neighborhood Hits	348	Shared Neighborhood Hits	99
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.086749 (rank : 115)
Query Neighborhood Hits	191	Target Neighborhood Hits	389	Shared Neighborhood Hits	101
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ES8L3_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.067919 (rank : 142)
Query Neighborhood Hits	191	Target Neighborhood Hits	206	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.068977 (rank : 139)
Query Neighborhood Hits	191	Target Neighborhood Hits	168	Shared Neighborhood Hits	87
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FNBP2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.059839 (rank : 174)
Query Neighborhood Hits	191	Target Neighborhood Hits	432	Shared Neighborhood Hits	99
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

IASPP_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.067071 (rank : 143)
Query Neighborhood Hits	191	Target Neighborhood Hits	688	Shared Neighborhood Hits	102
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.062115 (rank : 160)
Query Neighborhood Hits	191	Target Neighborhood Hits	1024	Shared Neighborhood Hits	107
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NCF1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.121115 (rank : 81)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	94
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.120916 (rank : 83)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	98
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.122274 (rank : 80)
Query Neighborhood Hits	191	Target Neighborhood Hits	161	Shared Neighborhood Hits	89
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.124703 (rank : 78)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	96
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.144001 (rank : 57)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	114
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NGEF_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.066690 (rank : 146)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NPHP1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.088878 (rank : 113)
Query Neighborhood Hits	191	Target Neighborhood Hits	288	Shared Neighborhood Hits	96
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.100262 (rank : 101)
Query Neighborhood Hits	191	Target Neighborhood Hits	267	Shared Neighborhood Hits	104
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

P85A_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.052442 (rank : 192)
Query Neighborhood Hits	191	Target Neighborhood Hits	479	Shared Neighborhood Hits	84
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.054522 (rank : 188)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	86
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PEX13_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.085818 (rank : 117)
Query Neighborhood Hits	191	Target Neighborhood Hits	128	Shared Neighborhood Hits	76
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PLCG1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.096347 (rank : 103)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	103
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.101140 (rank : 100)
Query Neighborhood Hits	191	Target Neighborhood Hits	314	Shared Neighborhood Hits	109
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RHG26_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.064979 (rank : 152)
Query Neighborhood Hits	191	Target Neighborhood Hits	281	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB2_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.072146 (rank : 133)
Query Neighborhood Hits	191	Target Neighborhood Hits	263	Shared Neighborhood Hits	83
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.069836 (rank : 136)
Query Neighborhood Hits	191	Target Neighborhood Hits	246	Shared Neighborhood Hits	74
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.068997 (rank : 138)
Query Neighborhood Hits	191	Target Neighborhood Hits	226	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.064672 (rank : 155)
Query Neighborhood Hits	191	Target Neighborhood Hits	206	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH3G1_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.114461 (rank : 94)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	110
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.114063 (rank : 95)
Query Neighborhood Hits	191	Target Neighborhood Hits	291	Shared Neighborhood Hits	108
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.120054 (rank : 86)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	111
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.117705 (rank : 90)
Query Neighborhood Hits	191	Target Neighborhood Hits	222	Shared Neighborhood Hits	105
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.123138 (rank : 79)
Query Neighborhood Hits	191	Target Neighborhood Hits	236	Shared Neighborhood Hits	108
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SHAN2_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.051555 (rank : 194)
Query Neighborhood Hits	191	Target Neighborhood Hits	446	Shared Neighborhood Hits	78
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLAP1_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.071038 (rank : 134)
Query Neighborhood Hits	191	Target Neighborhood Hits	113	Shared Neighborhood Hits	30
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.069387 (rank : 137)
Query Neighborhood Hits	191	Target Neighborhood Hits	117	Shared Neighborhood Hits	29
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.074594 (rank : 131)
Query Neighborhood Hits	191	Target Neighborhood Hits	139	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.074684 (rank : 130)
Query Neighborhood Hits	191	Target Neighborhood Hits	136	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPN90_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.059935 (rank : 173)
Query Neighborhood Hits	191	Target Neighborhood Hits	157	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.065125 (rank : 151)
Query Neighborhood Hits	191	Target Neighborhood Hits	157	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTA1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.060868 (rank : 167)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	113
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.060827 (rank : 168)
Query Neighborhood Hits	191	Target Neighborhood Hits	888	Shared Neighborhood Hits	116
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRC_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.056527 (rank : 182)
Query Neighborhood Hits	191	Target Neighborhood Hits	1058	Shared Neighborhood Hits	108
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.052132 (rank : 193)
Query Neighborhood Hits	191	Target Neighborhood Hits	1033	Shared Neighborhood Hits	96
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.057592 (rank : 180)
Query Neighborhood Hits	191	Target Neighborhood Hits	390	Shared Neighborhood Hits	92
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAM1_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.131816 (rank : 69)
Query Neighborhood Hits	191	Target Neighborhood Hits	271	Shared Neighborhood Hits	112
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.129102 (rank : 74)
Query Neighborhood Hits	191	Target Neighborhood Hits	273	Shared Neighborhood Hits	113
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.120489 (rank : 84)
Query Neighborhood Hits	191	Target Neighborhood Hits	288	Shared Neighborhood Hits	111
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.119340 (rank : 88)
Query Neighborhood Hits	191	Target Neighborhood Hits	285	Shared Neighborhood Hits	108
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STS2_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.060412 (rank : 170)
Query Neighborhood Hits	191	Target Neighborhood Hits	108	Shared Neighborhood Hits	67
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

Hits sorted by NC score

DOCK1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	191
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DOCK2_HUMAN
NC score	0.968881 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	191	Target Neighborhood Hits	90	Shared Neighborhood Hits	54
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
NC score	0.964812 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	191	Target Neighborhood Hits	104	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DOCK3_MOUSE
NC score	0.946908 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	191	Target Neighborhood Hits	93	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_HUMAN
NC score	0.946309 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	191	Target Neighborhood Hits	87	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK4_MOUSE
NC score	0.936070 (rank : 6)	θ value	0 (rank : 7)
Query Neighborhood Hits	191	Target Neighborhood Hits	210	Shared Neighborhood Hits	35
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_HUMAN
NC score	0.935049 (rank : 7)	θ value	0 (rank : 6)
Query Neighborhood Hits	191	Target Neighborhood Hits	237	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOC10_HUMAN
NC score	0.435049 (rank : 8)	θ value	8.38298e-14 (rank : 8)
Query Neighborhood Hits	191	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DOCK9_MOUSE
NC score	0.394920 (rank : 9)	θ value	1.133e-10 (rank : 9)
Query Neighborhood Hits	191	Target Neighborhood Hits	79	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_HUMAN
NC score	0.392638 (rank : 10)	θ value	1.9326e-10 (rank : 10)
Query Neighborhood Hits	191	Target Neighborhood Hits	82	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK8_MOUSE
NC score	0.389259 (rank : 11)	θ value	8.11959e-09 (rank : 11)
Query Neighborhood Hits	191	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C147, Q6PIS0, Q7TMQ5, Q8K105, Q9DBQ2	Gene names	Dock8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK8_HUMAN
NC score	0.381685 (rank : 12)	θ value	2.36244e-08 (rank : 13)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK7_HUMAN
NC score	0.377068 (rank : 13)	θ value	1.80886e-08 (rank : 12)
Query Neighborhood Hits	191	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q96N67, Q6ZV32, Q8TB82, Q96NG6, Q9C092	Gene names	DOCK7, KIAA1771
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 7.

DOCK6_HUMAN
NC score	0.363738 (rank : 14)	θ value	4.45536e-07 (rank : 14)
Query Neighborhood Hits	191	Target Neighborhood Hits	71	Shared Neighborhood Hits	15
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

VINEX_HUMAN
NC score	0.236457 (rank : 15)	θ value	0.0193708 (rank : 48)
Query Neighborhood Hits	191	Target Neighborhood Hits	270	Shared Neighborhood Hits	123
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.236445 (rank : 16)	θ value	0.0193708 (rank : 49)
Query Neighborhood Hits	191	Target Neighborhood Hits	286	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DNMBP_HUMAN
NC score	0.227782 (rank : 17)	θ value	0.00020696 (rank : 16)
Query Neighborhood Hits	191	Target Neighborhood Hits	413	Shared Neighborhood Hits	134
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

HCLS1_HUMAN
NC score	0.224287 (rank : 18)	θ value	0.000461057 (rank : 22)
Query Neighborhood Hits	191	Target Neighborhood Hits	358	Shared Neighborhood Hits	111
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

DNMBP_MOUSE
NC score	0.217638 (rank : 19)	θ value	0.000270298 (rank : 17)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	133
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRC8_HUMAN
NC score	0.215728 (rank : 20)	θ value	0.000270298 (rank : 18)
Query Neighborhood Hits	191	Target Neighborhood Hits	269	Shared Neighborhood Hits	115
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRBS1_HUMAN
NC score	0.214738 (rank : 21)	θ value	0.0148317 (rank : 43)
Query Neighborhood Hits	191	Target Neighborhood Hits	396	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_MOUSE
NC score	0.214674 (rank : 22)	θ value	0.00035302 (rank : 21)
Query Neighborhood Hits	191	Target Neighborhood Hits	292	Shared Neighborhood Hits	117
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRBS1_MOUSE
NC score	0.212398 (rank : 23)	θ value	0.0193708 (rank : 47)
Query Neighborhood Hits	191	Target Neighborhood Hits	409	Shared Neighborhood Hits	123
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CD2AP_HUMAN
NC score	0.211510 (rank : 24)	θ value	0.00390308 (rank : 26)
Query Neighborhood Hits	191	Target Neighborhood Hits	315	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

HCLS1_MOUSE
NC score	0.210690 (rank : 25)	θ value	0.00228821 (rank : 24)
Query Neighborhood Hits	191	Target Neighborhood Hits	329	Shared Neighborhood Hits	111
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CD2AP_MOUSE
NC score	0.209453 (rank : 26)	θ value	0.00035302 (rank : 19)
Query Neighborhood Hits	191	Target Neighborhood Hits	336	Shared Neighborhood Hits	121
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.183618 (rank : 27)	θ value	0.0193708 (rank : 46)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.183458 (rank : 28)	θ value	0.0193708 (rank : 45)
Query Neighborhood Hits	191	Target Neighborhood Hits	341	Shared Neighborhood Hits	120
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ABI2_HUMAN
NC score	0.180824 (rank : 29)	θ value	0.0113563 (rank : 33)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	116
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.177184 (rank : 30)	θ value	0.0148317 (rank : 40)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	114
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

GRAP_MOUSE
NC score	0.176848 (rank : 31)	θ value	0.0563607 (rank : 68)
Query Neighborhood Hits	191	Target Neighborhood Hits	309	Shared Neighborhood Hits	119
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ABI1_MOUSE
NC score	0.173902 (rank : 32)	θ value	0.0736092 (rank : 70)
Query Neighborhood Hits	191	Target Neighborhood Hits	246	Shared Neighborhood Hits	110
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

GRAP_HUMAN
NC score	0.173536 (rank : 33)	θ value	0.0563607 (rank : 67)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	118
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP2_HUMAN
NC score	0.172446 (rank : 34)	θ value	0.0431538 (rank : 59)
Query Neighborhood Hits	191	Target Neighborhood Hits	304	Shared Neighborhood Hits	112
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ABI1_HUMAN
NC score	0.171922 (rank : 35)	θ value	0.0330416 (rank : 55)
Query Neighborhood Hits	191	Target Neighborhood Hits	257	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

GRAP2_MOUSE
NC score	0.171356 (rank : 36)	θ value	0.0431538 (rank : 60)
Query Neighborhood Hits	191	Target Neighborhood Hits	297	Shared Neighborhood Hits	113
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PPIP1_HUMAN
NC score	0.168147 (rank : 37)	θ value	0.00665767 (rank : 30)
Query Neighborhood Hits	191	Target Neighborhood Hits	389	Shared Neighborhood Hits	124
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

NCF2_HUMAN
NC score	0.167361 (rank : 38)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	191	Target Neighborhood Hits	229	Shared Neighborhood Hits	108
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PPIP1_MOUSE
NC score	0.165801 (rank : 39)	θ value	0.0113563 (rank : 39)
Query Neighborhood Hits	191	Target Neighborhood Hits	377	Shared Neighborhood Hits	121
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

LASP1_HUMAN
NC score	0.163874 (rank : 40)	θ value	0.0113563 (rank : 37)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	109
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.163265 (rank : 41)	θ value	0.0113563 (rank : 38)
Query Neighborhood Hits	191	Target Neighborhood Hits	297	Shared Neighborhood Hits	109
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

GRB2_HUMAN
NC score	0.160955 (rank : 42)	θ value	0.21417 (rank : 87)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	113
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.160766 (rank : 43)	θ value	0.21417 (rank : 88)
Query Neighborhood Hits	191	Target Neighborhood Hits	312	Shared Neighborhood Hits	113
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

PACN1_MOUSE
NC score	0.158364 (rank : 44)	θ value	0.0431538 (rank : 65)
Query Neighborhood Hits	191	Target Neighborhood Hits	283	Shared Neighborhood Hits	116
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.157595 (rank : 45)	θ value	0.0431538 (rank : 64)
Query Neighborhood Hits	191	Target Neighborhood Hits	320	Shared Neighborhood Hits	118
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_MOUSE
NC score	0.152174 (rank : 46)	θ value	0.62314 (rank : 103)
Query Neighborhood Hits	191	Target Neighborhood Hits	382	Shared Neighborhood Hits	121
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

NCK1_HUMAN
NC score	0.151015 (rank : 47)	θ value	1.06291 (rank : 114)
Query Neighborhood Hits	191	Target Neighborhood Hits	312	Shared Neighborhood Hits	116
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PACN2_HUMAN
NC score	0.150101 (rank : 48)	θ value	0.62314 (rank : 102)
Query Neighborhood Hits	191	Target Neighborhood Hits	339	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

STAC_MOUSE
NC score	0.149275 (rank : 49)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	191	Target Neighborhood Hits	268	Shared Neighborhood Hits	114
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PACN3_MOUSE
NC score	0.148568 (rank : 50)	θ value	0.813845 (rank : 108)
Query Neighborhood Hits	191	Target Neighborhood Hits	380	Shared Neighborhood Hits	116
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.148080 (rank : 51)	θ value	0.813845 (rank : 107)
Query Neighborhood Hits	191	Target Neighborhood Hits	385	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

STAC_HUMAN
NC score	0.147208 (rank : 52)	θ value	3.0926 (rank : 152)
Query Neighborhood Hits	191	Target Neighborhood Hits	276	Shared Neighborhood Hits	113
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

DBNL_HUMAN
NC score	0.147175 (rank : 53)	θ value	0.365318 (rank : 94)
Query Neighborhood Hits	191	Target Neighborhood Hits	244	Shared Neighborhood Hits	99
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ARHG7_MOUSE
NC score	0.145893 (rank : 54)	θ value	0.163984 (rank : 84)
Query Neighborhood Hits	191	Target Neighborhood Hits	396	Shared Neighborhood Hits	124
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

NEBL_HUMAN
NC score	0.145706 (rank : 55)	θ value	0.0431538 (rank : 63)
Query Neighborhood Hits	191	Target Neighborhood Hits	457	Shared Neighborhood Hits	118
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

DBNL_MOUSE
NC score	0.145403 (rank : 56)	θ value	0.365318 (rank : 95)
Query Neighborhood Hits	191	Target Neighborhood Hits	306	Shared Neighborhood Hits	100
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NCK2_HUMAN
NC score	0.144001 (rank : 57)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	191	Target Neighborhood Hits	310	Shared Neighborhood Hits	114
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG7_HUMAN
NC score	0.141570 (rank : 58)	θ value	0.163984 (rank : 83)
Query Neighborhood Hits	191	Target Neighborhood Hits	347	Shared Neighborhood Hits	120
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV2_HUMAN
NC score	0.140338 (rank : 59)	θ value	0.0252991 (rank : 54)
Query Neighborhood Hits	191	Target Neighborhood Hits	453	Shared Neighborhood Hits	119
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.137886 (rank : 60)	θ value	0.0330416 (rank : 58)
Query Neighborhood Hits	191	Target Neighborhood Hits	456	Shared Neighborhood Hits	118
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

STAC3_HUMAN
NC score	0.136508 (rank : 61)	θ value	1.06291 (rank : 115)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	100
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
NC score	0.136322 (rank : 62)	θ value	1.06291 (rank : 116)
Query Neighborhood Hits	191	Target Neighborhood Hits	232	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ITSN1_MOUSE
NC score	0.133608 (rank : 63)	θ value	0.00869519 (rank : 32)
Query Neighborhood Hits	191	Target Neighborhood Hits	1669	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VAV_HUMAN
NC score	0.133531 (rank : 64)	θ value	0.0961366 (rank : 75)
Query Neighborhood Hits	191	Target Neighborhood Hits	452	Shared Neighborhood Hits	116
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

NEBU_HUMAN
NC score	0.133160 (rank : 65)	θ value	0.0252991 (rank : 52)
Query Neighborhood Hits	191	Target Neighborhood Hits	420	Shared Neighborhood Hits	110
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ARHG6_HUMAN
NC score	0.133154 (rank : 66)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	191	Target Neighborhood Hits	376	Shared Neighborhood Hits	120
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

VAV_MOUSE
NC score	0.132714 (rank : 67)	θ value	0.21417 (rank : 90)
Query Neighborhood Hits	191	Target Neighborhood Hits	430	Shared Neighborhood Hits	118
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG6_MOUSE
NC score	0.132149 (rank : 68)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	191	Target Neighborhood Hits	394	Shared Neighborhood Hits	116
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

STAM1_HUMAN
NC score	0.131816 (rank : 69)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	191	Target Neighborhood Hits	271	Shared Neighborhood Hits	112
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ITSN1_HUMAN
NC score	0.131802 (rank : 70)	θ value	0.0113563 (rank : 36)
Query Neighborhood Hits	191	Target Neighborhood Hits	1757	Shared Neighborhood Hits	144
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

AHI1_MOUSE
NC score	0.130542 (rank : 71)	θ value	0.0330416 (rank : 56)
Query Neighborhood Hits	191	Target Neighborhood Hits	496	Shared Neighborhood Hits	119
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ABI3_MOUSE
NC score	0.129306 (rank : 72)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_HUMAN
NC score	0.129221 (rank : 73)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	101
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAM1_MOUSE
NC score	0.129102 (rank : 74)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	191	Target Neighborhood Hits	273	Shared Neighborhood Hits	113
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

OSTF1_HUMAN
NC score	0.128376 (rank : 75)	θ value	0.0961366 (rank : 74)
Query Neighborhood Hits	191	Target Neighborhood Hits	466	Shared Neighborhood Hits	114
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

AHI1_HUMAN
NC score	0.128370 (rank : 76)	θ value	0.125558 (rank : 76)
Query Neighborhood Hits	191	Target Neighborhood Hits	537	Shared Neighborhood Hits	116
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

OSTF1_MOUSE
NC score	0.125652 (rank : 77)	θ value	0.163984 (rank : 85)
Query Neighborhood Hits	191	Target Neighborhood Hits	467	Shared Neighborhood Hits	115
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

NCF4_MOUSE
NC score	0.124703 (rank : 78)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	96
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SH3G3_MOUSE
NC score	0.123138 (rank : 79)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	191	Target Neighborhood Hits	236	Shared Neighborhood Hits	108
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

NCF4_HUMAN
NC score	0.122274 (rank : 80)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	191	Target Neighborhood Hits	161	Shared Neighborhood Hits	89
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF1_HUMAN
NC score	0.121115 (rank : 81)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	94
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

VAV3_HUMAN
NC score	0.120982 (rank : 82)	θ value	0.62314 (rank : 104)
Query Neighborhood Hits	191	Target Neighborhood Hits	398	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

NCF1_MOUSE
NC score	0.120916 (rank : 83)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	98
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

STAM2_HUMAN
NC score	0.120489 (rank : 84)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	191	Target Neighborhood Hits	288	Shared Neighborhood Hits	111
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SH3G2_MOUSE
NC score	0.120250 (rank : 85)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	191	Target Neighborhood Hits	319	Shared Neighborhood Hits	110
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G2_HUMAN
NC score	0.120054 (rank : 86)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	111
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ITSN2_HUMAN
NC score	0.119898 (rank : 87)	θ value	0.125558 (rank : 78)
Query Neighborhood Hits	191	Target Neighborhood Hits	1173	Shared Neighborhood Hits	128
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

STAM2_MOUSE
NC score	0.119340 (rank : 88)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	191	Target Neighborhood Hits	285	Shared Neighborhood Hits	108
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VAV3_MOUSE
NC score	0.118835 (rank : 89)	θ value	0.813845 (rank : 110)
Query Neighborhood Hits	191	Target Neighborhood Hits	404	Shared Neighborhood Hits	113
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SH3G3_HUMAN
NC score	0.117705 (rank : 90)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	191	Target Neighborhood Hits	222	Shared Neighborhood Hits	105
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CRKL_HUMAN
NC score	0.117531 (rank : 91)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	191	Target Neighborhood Hits	313	Shared Neighborhood Hits	111
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.115945 (rank : 92)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	109
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ITSN2_MOUSE
NC score	0.115577 (rank : 93)	θ value	0.125558 (rank : 79)
Query Neighborhood Hits	191	Target Neighborhood Hits	1371	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SH3G1_HUMAN
NC score	0.114461 (rank : 94)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	110
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
NC score	0.114063 (rank : 95)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	191	Target Neighborhood Hits	291	Shared Neighborhood Hits	108
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CRK_MOUSE
NC score	0.112132 (rank : 96)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	191	Target Neighborhood Hits	314	Shared Neighborhood Hits	111
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.110057 (rank : 97)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	191	Target Neighborhood Hits	308	Shared Neighborhood Hits	111
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SNX18_HUMAN
NC score	0.107844 (rank : 98)	θ value	1.38821 (rank : 118)
Query Neighborhood Hits	191	Target Neighborhood Hits	207	Shared Neighborhood Hits	90
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
NC score	0.103644 (rank : 99)	θ value	0.813845 (rank : 109)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	84
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PLCG1_MOUSE
NC score	0.101140 (rank : 100)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	191	Target Neighborhood Hits	314	Shared Neighborhood Hits	109
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NPHP1_MOUSE
NC score	0.100262 (rank : 101)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	191	Target Neighborhood Hits	267	Shared Neighborhood Hits	104
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PLCG2_HUMAN
NC score	0.100045 (rank : 102)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	191	Target Neighborhood Hits	280	Shared Neighborhood Hits	104
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_HUMAN
NC score	0.096347 (rank : 103)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	103
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

JIP2_MOUSE
NC score	0.096034 (rank : 104)	θ value	0.0252991 (rank : 51)
Query Neighborhood Hits	191	Target Neighborhood Hits	144	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

NOXO1_MOUSE
NC score	0.095436 (rank : 105)	θ value	2.36792 (rank : 135)
Query Neighborhood Hits	191	Target Neighborhood Hits	114	Shared Neighborhood Hits	71
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

DDEF2_MOUSE
NC score	0.094640 (rank : 106)	θ value	0.00869519 (rank : 31)
Query Neighborhood Hits	191	Target Neighborhood Hits	625	Shared Neighborhood Hits	97
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

JIP2_HUMAN
NC score	0.092889 (rank : 107)	θ value	0.0252991 (rank : 50)
Query Neighborhood Hits	191	Target Neighborhood Hits	288	Shared Neighborhood Hits	52
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

DDEF1_MOUSE
NC score	0.091856 (rank : 108)	θ value	0.47712 (rank : 97)
Query Neighborhood Hits	191	Target Neighborhood Hits	592	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

PEX13_MOUSE
NC score	0.090798 (rank : 109)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	191	Target Neighborhood Hits	126	Shared Neighborhood Hits	77
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CT032_HUMAN
NC score	0.090666 (rank : 110)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

ARHG4_HUMAN
NC score	0.090232 (rank : 111)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

DDEF2_HUMAN
NC score	0.090054 (rank : 112)	θ value	0.0563607 (rank : 66)
Query Neighborhood Hits	191	Target Neighborhood Hits	599	Shared Neighborhood Hits	101
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

NPHP1_HUMAN
NC score	0.088878 (rank : 113)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	191	Target Neighborhood Hits	288	Shared Neighborhood Hits	96
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

BCAR1_MOUSE
NC score	0.087689 (rank : 114)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	191	Target Neighborhood Hits	438	Shared Neighborhood Hits	104
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EFS_MOUSE
NC score	0.086749 (rank : 115)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	191	Target Neighborhood Hits	389	Shared Neighborhood Hits	101
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

BCAR1_HUMAN
NC score	0.086494 (rank : 116)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	191	Target Neighborhood Hits	554	Shared Neighborhood Hits	106
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PEX13_HUMAN
NC score	0.085818 (rank : 117)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	191	Target Neighborhood Hits	128	Shared Neighborhood Hits	76
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ARHG9_MOUSE
NC score	0.084567 (rank : 118)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	191	Target Neighborhood Hits	234	Shared Neighborhood Hits	99
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.084043 (rank : 119)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	100
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

MYO1F_MOUSE
NC score	0.083214 (rank : 120)	θ value	0.0148317 (rank : 42)
Query Neighborhood Hits	191	Target Neighborhood Hits	262	Shared Neighborhood Hits	114
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1F_HUMAN
NC score	0.082568 (rank : 121)	θ value	0.0193708 (rank : 44)
Query Neighborhood Hits	191	Target Neighborhood Hits	275	Shared Neighborhood Hits	115
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1E_HUMAN
NC score	0.082359 (rank : 122)	θ value	0.00298849 (rank : 25)
Query Neighborhood Hits	191	Target Neighborhood Hits	293	Shared Neighborhood Hits	112
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

EFS_HUMAN
NC score	0.082296 (rank : 123)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	191	Target Neighborhood Hits	348	Shared Neighborhood Hits	99
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ARHGG_MOUSE
NC score	0.081819 (rank : 124)	θ value	0.0113563 (rank : 34)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_MOUSE
NC score	0.080290 (rank : 125)	θ value	0.62314 (rank : 101)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

CASL_MOUSE
NC score	0.078871 (rank : 126)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	191	Target Neighborhood Hits	225	Shared Neighborhood Hits	94
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

RHG04_HUMAN
NC score	0.077679 (rank : 127)	θ value	3.0926 (rank : 147)
Query Neighborhood Hits	191	Target Neighborhood Hits	307	Shared Neighborhood Hits	95
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

JIP1_HUMAN
NC score	0.076081 (rank : 128)	θ value	0.125558 (rank : 80)
Query Neighborhood Hits	191	Target Neighborhood Hits	271	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
NC score	0.074852 (rank : 129)	θ value	0.21417 (rank : 89)
Query Neighborhood Hits	191	Target Neighborhood Hits	259	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SLAP2_MOUSE
NC score	0.074684 (rank : 130)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	191	Target Neighborhood Hits	136	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.074594 (rank : 131)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	191	Target Neighborhood Hits	139	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

CASL_HUMAN
NC score	0.073908 (rank : 132)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	191	Target Neighborhood Hits	259	Shared Neighborhood Hits	95
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

RIMB2_HUMAN
NC score	0.072146 (rank : 133)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	191	Target Neighborhood Hits	263	Shared Neighborhood Hits	83
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SLAP1_HUMAN
NC score	0.071038 (rank : 134)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	191	Target Neighborhood Hits	113	Shared Neighborhood Hits	30
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

ARHG4_MOUSE
NC score	0.070337 (rank : 135)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	191	Target Neighborhood Hits	185	Shared Neighborhood Hits	74
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RIMB2_MOUSE
NC score	0.069836 (rank : 136)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	191	Target Neighborhood Hits	246	Shared Neighborhood Hits	74
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SLAP1_MOUSE
NC score	0.069387 (rank : 137)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	191	Target Neighborhood Hits	117	Shared Neighborhood Hits	29
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

RUSC1_HUMAN
NC score	0.068997 (rank : 138)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	191	Target Neighborhood Hits	226	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ES8L3_MOUSE
NC score	0.068977 (rank : 139)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	191	Target Neighborhood Hits	168	Shared Neighborhood Hits	87
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ARHG5_HUMAN
NC score	0.068927 (rank : 140)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	191	Target Neighborhood Hits	172	Shared Neighborhood Hits	68
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ANM2_HUMAN
NC score	0.068262 (rank : 141)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	90
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ES8L3_HUMAN
NC score	0.067919 (rank : 142)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	191	Target Neighborhood Hits	206	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

IASPP_HUMAN
NC score	0.067071 (rank : 143)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	191	Target Neighborhood Hits	688	Shared Neighborhood Hits	102
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SNX9_HUMAN
NC score	0.067055 (rank : 144)	θ value	3.0926 (rank : 149)
Query Neighborhood Hits	191	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

ES8L2_MOUSE
NC score	0.066829 (rank : 145)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	191	Target Neighborhood Hits	169	Shared Neighborhood Hits	79
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

NGEF_HUMAN
NC score	0.066690 (rank : 146)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ES8L2_HUMAN
NC score	0.066265 (rank : 147)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	191	Target Neighborhood Hits	193	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

NOXO1_HUMAN
NC score	0.065795 (rank : 148)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	191	Target Neighborhood Hits	100	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

M3K9_HUMAN
NC score	0.065583 (rank : 149)	θ value	0.00035302 (rank : 20)
Query Neighborhood Hits	191	Target Neighborhood Hits	1123	Shared Neighborhood Hits	115
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SRGP2_MOUSE
NC score	0.065503 (rank : 150)	θ value	3.0926 (rank : 151)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	92
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SPN90_MOUSE
NC score	0.065125 (rank : 151)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	191	Target Neighborhood Hits	157	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

RHG26_HUMAN
NC score	0.064979 (rank : 152)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	191	Target Neighborhood Hits	281	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ARHGG_HUMAN
NC score	0.064915 (rank : 153)	θ value	1.06291 (rank : 112)
Query Neighborhood Hits	191	Target Neighborhood Hits	129	Shared Neighborhood Hits	42
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

M3KL4_HUMAN
NC score	0.064705 (rank : 154)	θ value	0.000158464 (rank : 15)
Query Neighborhood Hits	191	Target Neighborhood Hits	1087	Shared Neighborhood Hits	112
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

RUSC1_MOUSE
NC score	0.064672 (rank : 155)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	191	Target Neighborhood Hits	206	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ANM2_MOUSE
NC score	0.064236 (rank : 156)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SRGP2_HUMAN
NC score	0.064172 (rank : 157)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	191	Target Neighborhood Hits	331	Shared Neighborhood Hits	91
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

FGR_HUMAN
NC score	0.063238 (rank : 158)	θ value	0.0113563 (rank : 35)
Query Neighborhood Hits	191	Target Neighborhood Hits	1067	Shared Neighborhood Hits	105
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SPTA1_MOUSE
NC score	0.063109 (rank : 159)	θ value	0.125558 (rank : 81)
Query Neighborhood Hits	191	Target Neighborhood Hits	675	Shared Neighborhood Hits	106
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

IASPP_MOUSE
NC score	0.062115 (rank : 160)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	191	Target Neighborhood Hits	1024	Shared Neighborhood Hits	107
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

FYN_MOUSE
NC score	0.061902 (rank : 161)	θ value	0.0961366 (rank : 73)
Query Neighborhood Hits	191	Target Neighborhood Hits	1073	Shared Neighborhood Hits	109
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ASPP1_MOUSE
NC score	0.061509 (rank : 162)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	191	Target Neighborhood Hits	1244	Shared Neighborhood Hits	119
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

LYN_MOUSE
NC score	0.061437 (rank : 163)	θ value	0.00665767 (rank : 29)
Query Neighborhood Hits	191	Target Neighborhood Hits	1023	Shared Neighborhood Hits	105
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

HCK_MOUSE
NC score	0.061349 (rank : 164)	θ value	0.00665767 (rank : 28)
Query Neighborhood Hits	191	Target Neighborhood Hits	1029	Shared Neighborhood Hits	107
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

LYN_HUMAN
NC score	0.061003 (rank : 165)	θ value	0.00509761 (rank : 27)
Query Neighborhood Hits	191	Target Neighborhood Hits	1022	Shared Neighborhood Hits	105
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FYN_HUMAN
NC score	0.060949 (rank : 166)	θ value	0.0961366 (rank : 72)
Query Neighborhood Hits	191	Target Neighborhood Hits	1078	Shared Neighborhood Hits	109
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SPTA1_HUMAN
NC score	0.060868 (rank : 167)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	113
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
NC score	0.060827 (rank : 168)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	191	Target Neighborhood Hits	888	Shared Neighborhood Hits	116
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

FGR_MOUSE
NC score	0.060509 (rank : 169)	θ value	0.125558 (rank : 77)
Query Neighborhood Hits	191	Target Neighborhood Hits	1069	Shared Neighborhood Hits	106
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

STS2_HUMAN
NC score	0.060412 (rank : 170)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	191	Target Neighborhood Hits	108	Shared Neighborhood Hits	67
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

YES_MOUSE
NC score	0.060402 (rank : 171)	θ value	0.163984 (rank : 86)
Query Neighborhood Hits	191	Target Neighborhood Hits	1052	Shared Neighborhood Hits	102
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.060249 (rank : 172)	θ value	0.125558 (rank : 82)
Query Neighborhood Hits	191	Target Neighborhood Hits	1059	Shared Neighborhood Hits	102
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SPN90_HUMAN
NC score	0.059935 (rank : 173)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	191	Target Neighborhood Hits	157	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

FNBP2_HUMAN
NC score	0.059839 (rank : 174)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	191	Target Neighborhood Hits	432	Shared Neighborhood Hits	99
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ASPP1_HUMAN
NC score	0.059703 (rank : 175)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	191	Target Neighborhood Hits	956	Shared Neighborhood Hits	113
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

TCGAP_MOUSE
NC score	0.059683 (rank : 176)	θ value	2.36792 (rank : 138)
Query Neighborhood Hits	191	Target Neighborhood Hits	409	Shared Neighborhood Hits	83
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BIN3_HUMAN
NC score	0.058941 (rank : 177)	θ value	0.0736092 (rank : 71)
Query Neighborhood Hits	191	Target Neighborhood Hits	95	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQY0, Q9BVG2, Q9NVY9	Gene names	BIN3
Domain Architecture
Description	Bridging integrator 3.

HCK_HUMAN
NC score	0.058327 (rank : 178)	θ value	0.0330416 (rank : 57)
Query Neighborhood Hits	191	Target Neighborhood Hits	1035	Shared Neighborhood Hits	105
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

AMPH_HUMAN
NC score	0.057906 (rank : 179)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	191	Target Neighborhood Hits	455	Shared Neighborhood Hits	64
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

SRGP1_HUMAN
NC score	0.057592 (rank : 180)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	191	Target Neighborhood Hits	390	Shared Neighborhood Hits	92
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

AMPH_MOUSE
NC score	0.056978 (rank : 181)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	191	Target Neighborhood Hits	291	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

SRC_HUMAN
NC score	0.056527 (rank : 182)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	191	Target Neighborhood Hits	1058	Shared Neighborhood Hits	108
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

M3K11_HUMAN
NC score	0.056197 (rank : 183)	θ value	0.0431538 (rank : 62)
Query Neighborhood Hits	191	Target Neighborhood Hits	1136	Shared Neighborhood Hits	110
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SNX9_MOUSE
NC score	0.056064 (rank : 184)	θ value	3.0926 (rank : 150)
Query Neighborhood Hits	191	Target Neighborhood Hits	141	Shared Neighborhood Hits	53
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

M3K10_HUMAN
NC score	0.055927 (rank : 185)	θ value	0.0431538 (rank : 61)
Query Neighborhood Hits	191	Target Neighborhood Hits	1071	Shared Neighborhood Hits	109
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

EPS8_MOUSE
NC score	0.055457 (rank : 186)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	191	Target Neighborhood Hits	157	Shared Neighborhood Hits	77
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

FRK_HUMAN
NC score	0.054874 (rank : 187)	θ value	0.000786445 (rank : 23)
Query Neighborhood Hits	191	Target Neighborhood Hits	1058	Shared Neighborhood Hits	104
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

P85A_MOUSE
NC score	0.054522 (rank : 188)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	86
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

TCGAP_HUMAN
NC score	0.053673 (rank : 189)	θ value	2.36792 (rank : 137)
Query Neighborhood Hits	191	Target Neighborhood Hits	872	Shared Neighborhood Hits	86
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BIN1_HUMAN
NC score	0.053417 (rank : 190)	θ value	8.99809 (rank : 179)
Query Neighborhood Hits	191	Target Neighborhood Hits	335	Shared Neighborhood Hits	60
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
NC score	0.052540 (rank : 191)	θ value	8.99809 (rank : 180)
Query Neighborhood Hits	191	Target Neighborhood Hits	283	Shared Neighborhood Hits	65
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

P85A_HUMAN
NC score	0.052442 (rank : 192)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	191	Target Neighborhood Hits	479	Shared Neighborhood Hits	84
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SRC_MOUSE
NC score	0.052132 (rank : 193)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	191	Target Neighborhood Hits	1033	Shared Neighborhood Hits	96
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SHAN2_MOUSE
NC score	0.051555 (rank : 194)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	191	Target Neighborhood Hits	446	Shared Neighborhood Hits	78
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

BTK_HUMAN
NC score	0.051367 (rank : 195)	θ value	0.813845 (rank : 105)
Query Neighborhood Hits	191	Target Neighborhood Hits	1026	Shared Neighborhood Hits	103
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.049857 (rank : 196)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	191	Target Neighborhood Hits	1017	Shared Neighborhood Hits	101
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

PTK6_MOUSE
NC score	0.048554 (rank : 197)	θ value	0.0252991 (rank : 53)
Query Neighborhood Hits	191	Target Neighborhood Hits	1026	Shared Neighborhood Hits	94
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

BIN3_MOUSE
NC score	0.048379 (rank : 198)	θ value	0.62314 (rank : 99)
Query Neighborhood Hits	191	Target Neighborhood Hits	165	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JI08	Gene names	Bin3
Domain Architecture	No domain graphic available
Description	Bridging integrator 3.

CSK_HUMAN
NC score	0.047895 (rank : 199)	θ value	1.81305 (rank : 121)
Query Neighborhood Hits	191	Target Neighborhood Hits	1009	Shared Neighborhood Hits	95
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.047826 (rank : 200)	θ value	1.81305 (rank : 122)
Query Neighborhood Hits	191	Target Neighborhood Hits	1009	Shared Neighborhood Hits	95
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

PTK6_HUMAN
NC score	0.043825 (rank : 201)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	191	Target Neighborhood Hits	1020	Shared Neighborhood Hits	94
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SLC2B_HUMAN
NC score	0.042660 (rank : 202)	θ value	0.0563607 (rank : 69)
Query Neighborhood Hits	191	Target Neighborhood Hits	214	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

APOB_HUMAN
NC score	0.042139 (rank : 203)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	191	Target Neighborhood Hits	202	Shared Neighborhood Hits	13
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

TEC_MOUSE
NC score	0.041077 (rank : 204)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	191	Target Neighborhood Hits	1006	Shared Neighborhood Hits	92
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SRMS_MOUSE
NC score	0.040258 (rank : 205)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	191	Target Neighborhood Hits	964	Shared Neighborhood Hits	73
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

FUT8_HUMAN
NC score	0.039869 (rank : 206)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	191	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

K0423_HUMAN
NC score	0.037772 (rank : 207)	θ value	0.279714 (rank : 92)
Query Neighborhood Hits	191	Target Neighborhood Hits	171	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y4F4, Q68D66, Q6PG27	Gene names	KIAA0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

NCOA6_HUMAN
NC score	0.036447 (rank : 208)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	191	Target Neighborhood Hits	1202	Shared Neighborhood Hits	29
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

CTR9_MOUSE
NC score	0.031783 (rank : 209)	θ value	0.279714 (rank : 91)
Query Neighborhood Hits	191	Target Neighborhood Hits	427	Shared Neighborhood Hits	13
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

CTR9_HUMAN
NC score	0.031503 (rank : 210)	θ value	0.365318 (rank : 93)
Query Neighborhood Hits	191	Target Neighborhood Hits	383	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PD62, Q15015	Gene names	CTR9, KIAA0155, SH2BP1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1).

BCL9_HUMAN
NC score	0.028249 (rank : 211)	θ value	0.0148317 (rank : 41)
Query Neighborhood Hits	191	Target Neighborhood Hits	1008	Shared Neighborhood Hits	21
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

MYO15_MOUSE
NC score	0.026813 (rank : 212)	θ value	0.47712 (rank : 98)
Query Neighborhood Hits	191	Target Neighborhood Hits	467	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

K0423_MOUSE
NC score	0.025978 (rank : 213)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	191	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

INGR1_MOUSE
NC score	0.025560 (rank : 214)	θ value	0.813845 (rank : 106)
Query Neighborhood Hits	191	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	P15261	Gene names	Ifngr1, Ifngr
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen).

ARAF_HUMAN
NC score	0.025177 (rank : 215)	θ value	1.06291 (rank : 111)
Query Neighborhood Hits	191	Target Neighborhood Hits	924	Shared Neighborhood Hits	34
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

RRFM_HUMAN
NC score	0.024323 (rank : 216)	θ value	3.0926 (rank : 148)
Query Neighborhood Hits	191	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q96E11, Q5RKT1, Q5T7T0, Q5T7T1, Q5T7T2, Q5T7T3, Q5T7T4, Q5T7T5	Gene names	MRRF
Domain Architecture	No domain graphic available
Description	Ribosome recycling factor, mitochondrial precursor.

ZN277_HUMAN
NC score	0.023585 (rank : 217)	θ value	1.81305 (rank : 130)
Query Neighborhood Hits	191	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRM2	Gene names	ZNF277
Domain Architecture	No domain graphic available
Description	Zinc finger protein 277.

RRFM_MOUSE
NC score	0.022001 (rank : 218)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	191	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D6S7	Gene names	Mrrf
Domain Architecture	No domain graphic available
Description	Ribosome recycling factor, mitochondrial precursor.

ADX_HUMAN
NC score	0.020526 (rank : 219)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	191	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P10109, Q53YD6	Gene names	FDX1, ADX
Domain Architecture
Description	Adrenodoxin, mitochondrial precursor (Adrenal ferredoxin) (Ferredoxin- 1) (Hepatoredoxin).

PYGO2_HUMAN
NC score	0.016753 (rank : 220)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	191	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

MACF1_HUMAN
NC score	0.015941 (rank : 221)	θ value	3.0926 (rank : 143)
Query Neighborhood Hits	191	Target Neighborhood Hits	1341	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

CNOT4_MOUSE
NC score	0.015084 (rank : 222)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	191	Target Neighborhood Hits	277	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

ZBED1_HUMAN
NC score	0.014836 (rank : 223)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	191	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O96006, Q96BY4	Gene names	ZBED1, ALTE, DREF, KIAA0785, TRAMP
Domain Architecture
Description	Zinc finger BED domain-containing protein 1 (dREF homolog) (Putative Ac-like transposable element).

KNTC2_MOUSE
NC score	0.014654 (rank : 224)	θ value	0.365318 (rank : 96)
Query Neighborhood Hits	191	Target Neighborhood Hits	692	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

KTN1_MOUSE
NC score	0.014017 (rank : 225)	θ value	1.38821 (rank : 117)
Query Neighborhood Hits	191	Target Neighborhood Hits	1324	Shared Neighborhood Hits	32
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

ARI5B_HUMAN
NC score	0.013752 (rank : 226)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	191	Target Neighborhood Hits	328	Shared Neighborhood Hits	8
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

HUCE1_MOUSE
NC score	0.013668 (rank : 227)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	191	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DB85, Q8BHW3	Gene names
Domain Architecture	No domain graphic available
Description	Cerebral protein 1 homolog.

CRSP7_HUMAN
NC score	0.013412 (rank : 228)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	191	Target Neighborhood Hits	247	Shared Neighborhood Hits	10
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

BPAEA_HUMAN
NC score	0.013290 (rank : 229)	θ value	3.0926 (rank : 141)
Query Neighborhood Hits	191	Target Neighborhood Hits	1369	Shared Neighborhood Hits	31
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

MACF4_HUMAN
NC score	0.013201 (rank : 230)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	191	Target Neighborhood Hits	1321	Shared Neighborhood Hits	31
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

CEP70_HUMAN
NC score	0.012300 (rank : 231)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	191	Target Neighborhood Hits	432	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

SPRL1_HUMAN
NC score	0.011262 (rank : 232)	θ value	2.36792 (rank : 136)
Query Neighborhood Hits	191	Target Neighborhood Hits	231	Shared Neighborhood Hits	6
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

MILK1_MOUSE
NC score	0.011016 (rank : 233)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	191	Target Neighborhood Hits	788	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

CI082_MOUSE
NC score	0.010909 (rank : 234)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	191	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDY9	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf82 homolog.

RYR2_HUMAN
NC score	0.010551 (rank : 235)	θ value	1.81305 (rank : 126)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

COHA1_HUMAN
NC score	0.010243 (rank : 236)	θ value	1.06291 (rank : 113)
Query Neighborhood Hits	191	Target Neighborhood Hits	400	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CCNB1_MOUSE
NC score	0.010229 (rank : 237)	θ value	1.81305 (rank : 120)
Query Neighborhood Hits	191	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	P24860	Gene names	Ccnb1, Ccn-2, Ccnb1-rs13, Cycb, Cycb1
Domain Architecture
Description	G2/mitotic-specific cyclin-B1.

NCOA2_HUMAN
NC score	0.010136 (rank : 238)	θ value	1.81305 (rank : 125)
Query Neighborhood Hits	191	Target Neighborhood Hits	281	Shared Neighborhood Hits	9
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

TBCD4_HUMAN
NC score	0.010061 (rank : 239)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	191	Target Neighborhood Hits	357	Shared Neighborhood Hits	8
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

KTN1_HUMAN
NC score	0.009903 (rank : 240)	θ value	2.36792 (rank : 134)
Query Neighborhood Hits	191	Target Neighborhood Hits	1197	Shared Neighborhood Hits	22
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

SYNE1_HUMAN
NC score	0.009865 (rank : 241)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	191	Target Neighborhood Hits	1484	Shared Neighborhood Hits	37
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CD2_HUMAN
NC score	0.009836 (rank : 242)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	191	Target Neighborhood Hits	504	Shared Neighborhood Hits	14
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

LRC18_HUMAN
NC score	0.009519 (rank : 243)	θ value	0.62314 (rank : 100)
Query Neighborhood Hits	191	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N456, Q6UY02	Gene names	LRRC18
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 18.

RTEL1_HUMAN
NC score	0.009055 (rank : 244)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	191	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

FLIP1_HUMAN
NC score	0.008951 (rank : 245)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	191	Target Neighborhood Hits	1405	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGA4_MOUSE
NC score	0.007499 (rank : 246)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	191	Target Neighborhood Hits	1939	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

RBL2_HUMAN
NC score	0.005979 (rank : 247)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	191	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q08999, Q15073, Q16084, Q92812	Gene names	RBL2, RB2
Domain Architecture
Description	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).

TP53B_HUMAN
NC score	0.005418 (rank : 248)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	191	Target Neighborhood Hits	413	Shared Neighborhood Hits	10
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ANGP2_MOUSE
NC score	0.003863 (rank : 249)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	191	Target Neighborhood Hits	397	Shared Neighborhood Hits	15
SwissProt Accessions	O35608, Q3U1A1, Q9D2D2	Gene names	Angpt2, Agpt2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

SEPT2_MOUSE
NC score	0.003469 (rank : 250)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	191	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	P42208, Q3U9Y5	Gene names	Sept2, Nedd-5, Nedd5
Domain Architecture
Description	Septin-2 (Protein NEDD5) (Neural precursor cell expressed developmentally down-regulated protein 5).

SEPT2_HUMAN
NC score	0.003468 (rank : 251)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	191	Target Neighborhood Hits	101	Shared Neighborhood Hits	3
SwissProt Accessions	Q15019, Q14132, Q8IUK9, Q96CB0	Gene names	SEPT2, DIFF6, KIAA0158, NEDD5
Domain Architecture
Description	Septin-2 (Protein NEDD5).

CP4FB_HUMAN
NC score	0.002667 (rank : 252)	θ value	3.0926 (rank : 142)
Query Neighborhood Hits	191	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBI6, O75254, Q96AQ5	Gene names	CYP4F11
Domain Architecture
Description	Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11).

ZHX2_MOUSE
NC score	0.002654 (rank : 253)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	191	Target Neighborhood Hits	435	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0C0	Gene names	Zhx2, Afr1, Raf
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

CO5A3_HUMAN
NC score	0.002424 (rank : 254)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	191	Target Neighborhood Hits	433	Shared Neighborhood Hits	12
SwissProt Accessions	P25940, Q9NZQ6	Gene names	COL5A3
Domain Architecture
Description	Collagen alpha-3(V) chain precursor.

ZEP1_HUMAN
NC score	0.001704 (rank : 255)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	191	Target Neighborhood Hits	1036	Shared Neighborhood Hits	12
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

BAI2_HUMAN
NC score	0.000503 (rank : 256)	θ value	8.99809 (rank : 178)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

TENX_HUMAN
NC score	-0.001600 (rank : 257)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	191	Target Neighborhood Hits	789	Shared Neighborhood Hits	7
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

ZN435_HUMAN
NC score	-0.003990 (rank : 258)	θ value	4.03905 (rank : 159)
Query Neighborhood Hits	191	Target Neighborhood Hits	774	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H4T2, Q9H6K2	Gene names	ZNF435, ZSCAN16
Domain Architecture
Description	Zinc finger protein 435 (Zinc finger and SCAN domain-containing protein 16).