Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : ARHG6_HUMAN

For an explanation of this page, click here

ARHG6_HUMAN
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARHG6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	376	Target Neighborhood Hits	376	Shared Neighborhood Hits	376
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0 (rank : 2)	NC score	0.986476 (rank : 2)
Query Neighborhood Hits	376	Target Neighborhood Hits	394	Shared Neighborhood Hits	327
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	0 (rank : 3)	NC score	0.954858 (rank : 3)
Query Neighborhood Hits	376	Target Neighborhood Hits	347	Shared Neighborhood Hits	265
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	3.96267e-181 (rank : 4)	NC score	0.941658 (rank : 4)
Query Neighborhood Hits	376	Target Neighborhood Hits	396	Shared Neighborhood Hits	270
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

PKHG1_HUMAN
θ value	3.62785e-25 (rank : 5)	NC score	0.631240 (rank : 13)
Query Neighborhood Hits	376	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG4_HUMAN
θ value	1.99067e-23 (rank : 6)	NC score	0.741355 (rank : 5)
Query Neighborhood Hits	376	Target Neighborhood Hits	242	Shared Neighborhood Hits	197
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	1.42661e-21 (rank : 7)	NC score	0.710356 (rank : 8)
Query Neighborhood Hits	376	Target Neighborhood Hits	185	Shared Neighborhood Hits	153
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ITSN1_HUMAN
θ value	3.17815e-21 (rank : 8)	NC score	0.551372 (rank : 26)
Query Neighborhood Hits	376	Target Neighborhood Hits	1757	Shared Neighborhood Hits	329
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PREX1_HUMAN
θ value	5.42112e-21 (rank : 9)	NC score	0.580298 (rank : 23)
Query Neighborhood Hits	376	Target Neighborhood Hits	177	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ITSN2_HUMAN
θ value	1.2077e-20 (rank : 10)	NC score	0.589423 (rank : 22)
Query Neighborhood Hits	376	Target Neighborhood Hits	1173	Shared Neighborhood Hits	314
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_MOUSE
θ value	2.06002e-20 (rank : 11)	NC score	0.550859 (rank : 27)
Query Neighborhood Hits	376	Target Neighborhood Hits	1669	Shared Neighborhood Hits	327
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_MOUSE
θ value	1.74391e-19 (rank : 12)	NC score	0.560207 (rank : 24)
Query Neighborhood Hits	376	Target Neighborhood Hits	1371	Shared Neighborhood Hits	317
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG9_HUMAN
θ value	9.56915e-18 (rank : 13)	NC score	0.719311 (rank : 6)
Query Neighborhood Hits	376	Target Neighborhood Hits	235	Shared Neighborhood Hits	189
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	1.24977e-17 (rank : 14)	NC score	0.718644 (rank : 7)
Query Neighborhood Hits	376	Target Neighborhood Hits	234	Shared Neighborhood Hits	189
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

TRIO_HUMAN
θ value	1.38178e-16 (rank : 15)	NC score	0.220381 (rank : 188)
Query Neighborhood Hits	376	Target Neighborhood Hits	1580	Shared Neighborhood Hits	186
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

HAPIP_HUMAN
θ value	2.35696e-16 (rank : 16)	NC score	0.479173 (rank : 60)
Query Neighborhood Hits	376	Target Neighborhood Hits	350	Shared Neighborhood Hits	111
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

VAV3_MOUSE
θ value	1.99529e-15 (rank : 17)	NC score	0.618507 (rank : 17)
Query Neighborhood Hits	376	Target Neighborhood Hits	404	Shared Neighborhood Hits	240
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
θ value	3.76295e-14 (rank : 18)	NC score	0.616288 (rank : 18)
Query Neighborhood Hits	376	Target Neighborhood Hits	398	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

TIAM1_HUMAN
θ value	2.43908e-13 (rank : 19)	NC score	0.546413 (rank : 28)
Query Neighborhood Hits	376	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	3.18553e-13 (rank : 20)	NC score	0.551723 (rank : 25)
Query Neighborhood Hits	376	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD4_MOUSE
θ value	5.43371e-13 (rank : 21)	NC score	0.429183 (rank : 87)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

VAV2_HUMAN
θ value	2.0648e-12 (rank : 22)	NC score	0.624841 (rank : 14)
Query Neighborhood Hits	376	Target Neighborhood Hits	453	Shared Neighborhood Hits	242
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

FGD4_HUMAN
θ value	4.59992e-12 (rank : 23)	NC score	0.428815 (rank : 88)
Query Neighborhood Hits	376	Target Neighborhood Hits	219	Shared Neighborhood Hits	78
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

SH3K1_HUMAN
θ value	7.84624e-12 (rank : 24)	NC score	0.620464 (rank : 15)
Query Neighborhood Hits	376	Target Neighborhood Hits	341	Shared Neighborhood Hits	212
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

FARP2_MOUSE
θ value	1.33837e-11 (rank : 25)	NC score	0.351602 (rank : 119)
Query Neighborhood Hits	376	Target Neighborhood Hits	209	Shared Neighborhood Hits	67
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

DNMBP_MOUSE
θ value	1.74796e-11 (rank : 26)	NC score	0.687934 (rank : 9)
Query Neighborhood Hits	376	Target Neighborhood Hits	435	Shared Neighborhood Hits	233
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
θ value	2.98157e-11 (rank : 27)	NC score	0.685832 (rank : 10)
Query Neighborhood Hits	376	Target Neighborhood Hits	413	Shared Neighborhood Hits	241
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV_HUMAN
θ value	2.98157e-11 (rank : 28)	NC score	0.634449 (rank : 12)
Query Neighborhood Hits	376	Target Neighborhood Hits	452	Shared Neighborhood Hits	249
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

FARP2_HUMAN
θ value	5.08577e-11 (rank : 29)	NC score	0.335442 (rank : 123)
Query Neighborhood Hits	376	Target Neighborhood Hits	240	Shared Neighborhood Hits	65
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SH3K1_MOUSE
θ value	6.64225e-11 (rank : 30)	NC score	0.611943 (rank : 19)
Query Neighborhood Hits	376	Target Neighborhood Hits	332	Shared Neighborhood Hits	213
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

DUET_HUMAN
θ value	1.133e-10 (rank : 31)	NC score	0.195842 (rank : 201)
Query Neighborhood Hits	376	Target Neighborhood Hits	1220	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

CD2AP_MOUSE
θ value	1.9326e-10 (rank : 32)	NC score	0.607560 (rank : 20)
Query Neighborhood Hits	376	Target Neighborhood Hits	336	Shared Neighborhood Hits	203
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ARHG8_MOUSE
θ value	4.30538e-10 (rank : 33)	NC score	0.477938 (rank : 61)
Query Neighborhood Hits	376	Target Neighborhood Hits	79	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

FGD3_MOUSE
θ value	4.30538e-10 (rank : 34)	NC score	0.416003 (rank : 93)
Query Neighborhood Hits	376	Target Neighborhood Hits	257	Shared Neighborhood Hits	67
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FARP1_HUMAN
θ value	5.62301e-10 (rank : 35)	NC score	0.311292 (rank : 133)
Query Neighborhood Hits	376	Target Neighborhood Hits	241	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MCF2_HUMAN
θ value	7.34386e-10 (rank : 36)	NC score	0.534762 (rank : 31)
Query Neighborhood Hits	376	Target Neighborhood Hits	166	Shared Neighborhood Hits	77
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

OSTF1_MOUSE
θ value	9.59137e-10 (rank : 37)	NC score	0.423178 (rank : 90)
Query Neighborhood Hits	376	Target Neighborhood Hits	467	Shared Neighborhood Hits	192
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OSTF1_HUMAN
θ value	1.25267e-09 (rank : 38)	NC score	0.432010 (rank : 84)
Query Neighborhood Hits	376	Target Neighborhood Hits	466	Shared Neighborhood Hits	191
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

NCK1_HUMAN
θ value	4.76016e-09 (rank : 39)	NC score	0.523674 (rank : 37)
Query Neighborhood Hits	376	Target Neighborhood Hits	312	Shared Neighborhood Hits	188
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CD2AP_HUMAN
θ value	6.21693e-09 (rank : 40)	NC score	0.606366 (rank : 21)
Query Neighborhood Hits	376	Target Neighborhood Hits	315	Shared Neighborhood Hits	208
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

FGD2_HUMAN
θ value	1.38499e-08 (rank : 41)	NC score	0.414543 (rank : 94)
Query Neighborhood Hits	376	Target Neighborhood Hits	151	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

MCF2L_MOUSE
θ value	1.80886e-08 (rank : 42)	NC score	0.525845 (rank : 34)
Query Neighborhood Hits	376	Target Neighborhood Hits	255	Shared Neighborhood Hits	107
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

PLCG1_HUMAN
θ value	1.80886e-08 (rank : 43)	NC score	0.382952 (rank : 108)
Query Neighborhood Hits	376	Target Neighborhood Hits	293	Shared Neighborhood Hits	152
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV_MOUSE
θ value	3.08544e-08 (rank : 44)	NC score	0.639878 (rank : 11)
Query Neighborhood Hits	376	Target Neighborhood Hits	430	Shared Neighborhood Hits	250
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ABI2_HUMAN
θ value	4.0297e-08 (rank : 45)	NC score	0.526178 (rank : 33)
Query Neighborhood Hits	376	Target Neighborhood Hits	350	Shared Neighborhood Hits	178
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	4.0297e-08 (rank : 46)	NC score	0.530739 (rank : 32)
Query Neighborhood Hits	376	Target Neighborhood Hits	266	Shared Neighborhood Hits	178
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PLCG1_MOUSE
θ value	4.0297e-08 (rank : 47)	NC score	0.390353 (rank : 100)
Query Neighborhood Hits	376	Target Neighborhood Hits	314	Shared Neighborhood Hits	156
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	5.26297e-08 (rank : 48)	NC score	0.383721 (rank : 106)
Query Neighborhood Hits	376	Target Neighborhood Hits	280	Shared Neighborhood Hits	149
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV2_MOUSE
θ value	5.26297e-08 (rank : 49)	NC score	0.620122 (rank : 16)
Query Neighborhood Hits	376	Target Neighborhood Hits	456	Shared Neighborhood Hits	242
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

NCK2_HUMAN
θ value	6.87365e-08 (rank : 50)	NC score	0.512858 (rank : 39)
Query Neighborhood Hits	376	Target Neighborhood Hits	310	Shared Neighborhood Hits	187
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHGA_HUMAN
θ value	1.99992e-07 (rank : 51)	NC score	0.445309 (rank : 77)
Query Neighborhood Hits	376	Target Neighborhood Hits	187	Shared Neighborhood Hits	71
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SHAN1_HUMAN
θ value	1.99992e-07 (rank : 52)	NC score	0.212920 (rank : 191)
Query Neighborhood Hits	376	Target Neighborhood Hits	1041	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ARHG3_HUMAN
θ value	3.41135e-07 (rank : 53)	NC score	0.484361 (rank : 55)
Query Neighborhood Hits	376	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

CNN1_HUMAN
θ value	3.41135e-07 (rank : 54)	NC score	0.243398 (rank : 163)
Query Neighborhood Hits	376	Target Neighborhood Hits	38	Shared Neighborhood Hits	30
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

VINEX_MOUSE
θ value	3.41135e-07 (rank : 55)	NC score	0.542990 (rank : 30)
Query Neighborhood Hits	376	Target Neighborhood Hits	286	Shared Neighborhood Hits	189
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ARHG3_MOUSE
θ value	4.45536e-07 (rank : 56)	NC score	0.484354 (rank : 56)
Query Neighborhood Hits	376	Target Neighborhood Hits	85	Shared Neighborhood Hits	58
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

CNN1_MOUSE
θ value	4.45536e-07 (rank : 57)	NC score	0.243209 (rank : 164)
Query Neighborhood Hits	376	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

VINEX_HUMAN
θ value	7.59969e-07 (rank : 58)	NC score	0.543063 (rank : 29)
Query Neighborhood Hits	376	Target Neighborhood Hits	270	Shared Neighborhood Hits	187
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABI1_HUMAN
θ value	9.92553e-07 (rank : 59)	NC score	0.493516 (rank : 49)
Query Neighborhood Hits	376	Target Neighborhood Hits	257	Shared Neighborhood Hits	167
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G2_HUMAN
θ value	1.29631e-06 (rank : 60)	NC score	0.488212 (rank : 52)
Query Neighborhood Hits	376	Target Neighborhood Hits	324	Shared Neighborhood Hits	197
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SRBS1_HUMAN
θ value	1.29631e-06 (rank : 61)	NC score	0.524777 (rank : 36)
Query Neighborhood Hits	376	Target Neighborhood Hits	396	Shared Neighborhood Hits	203
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G1_HUMAN
θ value	1.69304e-06 (rank : 62)	NC score	0.475471 (rank : 63)
Query Neighborhood Hits	376	Target Neighborhood Hits	307	Shared Neighborhood Hits	196
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G3_MOUSE
θ value	1.69304e-06 (rank : 63)	NC score	0.502637 (rank : 44)
Query Neighborhood Hits	376	Target Neighborhood Hits	236	Shared Neighborhood Hits	189
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ABI1_MOUSE
θ value	2.21117e-06 (rank : 64)	NC score	0.505026 (rank : 43)
Query Neighborhood Hits	376	Target Neighborhood Hits	246	Shared Neighborhood Hits	169
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G2_MOUSE
θ value	2.21117e-06 (rank : 65)	NC score	0.482442 (rank : 59)
Query Neighborhood Hits	376	Target Neighborhood Hits	319	Shared Neighborhood Hits	202
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SRBS1_MOUSE
θ value	2.21117e-06 (rank : 66)	NC score	0.525823 (rank : 35)
Query Neighborhood Hits	376	Target Neighborhood Hits	409	Shared Neighborhood Hits	192
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ARHGA_MOUSE
θ value	2.88788e-06 (rank : 67)	NC score	0.448572 (rank : 73)
Query Neighborhood Hits	376	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

GRAP_MOUSE
θ value	3.77169e-06 (rank : 68)	NC score	0.497075 (rank : 46)
Query Neighborhood Hits	376	Target Neighborhood Hits	309	Shared Neighborhood Hits	191
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

MYO1E_HUMAN
θ value	3.77169e-06 (rank : 69)	NC score	0.236562 (rank : 173)
Query Neighborhood Hits	376	Target Neighborhood Hits	293	Shared Neighborhood Hits	196
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

CNN3_HUMAN
θ value	6.43352e-06 (rank : 70)	NC score	0.239723 (rank : 170)
Query Neighborhood Hits	376	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_MOUSE
θ value	6.43352e-06 (rank : 71)	NC score	0.239655 (rank : 171)
Query Neighborhood Hits	376	Target Neighborhood Hits	45	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

FYN_HUMAN
θ value	8.40245e-06 (rank : 72)	NC score	0.169962 (rank : 223)
Query Neighborhood Hits	376	Target Neighborhood Hits	1078	Shared Neighborhood Hits	188
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	8.40245e-06 (rank : 73)	NC score	0.173248 (rank : 217)
Query Neighborhood Hits	376	Target Neighborhood Hits	1073	Shared Neighborhood Hits	188
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GRB2_HUMAN
θ value	8.40245e-06 (rank : 74)	NC score	0.506003 (rank : 41)
Query Neighborhood Hits	376	Target Neighborhood Hits	310	Shared Neighborhood Hits	185
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	8.40245e-06 (rank : 75)	NC score	0.505849 (rank : 42)
Query Neighborhood Hits	376	Target Neighborhood Hits	312	Shared Neighborhood Hits	185
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SH3G3_HUMAN
θ value	8.40245e-06 (rank : 76)	NC score	0.483897 (rank : 58)
Query Neighborhood Hits	376	Target Neighborhood Hits	222	Shared Neighborhood Hits	178
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

AHI1_HUMAN
θ value	1.09739e-05 (rank : 77)	NC score	0.364838 (rank : 115)
Query Neighborhood Hits	376	Target Neighborhood Hits	537	Shared Neighborhood Hits	187
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CNN2_MOUSE
θ value	1.09739e-05 (rank : 78)	NC score	0.240907 (rank : 168)
Query Neighborhood Hits	376	Target Neighborhood Hits	39	Shared Neighborhood Hits	30
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

FGD2_MOUSE
θ value	1.43324e-05 (rank : 79)	NC score	0.394713 (rank : 98)
Query Neighborhood Hits	376	Target Neighborhood Hits	163	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ECT2_MOUSE
θ value	1.87187e-05 (rank : 80)	NC score	0.448605 (rank : 72)
Query Neighborhood Hits	376	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PKHG4_HUMAN
θ value	1.87187e-05 (rank : 81)	NC score	0.445263 (rank : 78)
Query Neighborhood Hits	376	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SOS1_HUMAN
θ value	1.87187e-05 (rank : 82)	NC score	0.269464 (rank : 151)
Query Neighborhood Hits	376	Target Neighborhood Hits	274	Shared Neighborhood Hits	39
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ALS2_MOUSE
θ value	2.44474e-05 (rank : 83)	NC score	0.111366 (rank : 294)
Query Neighborhood Hits	376	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ECT2_HUMAN
θ value	2.44474e-05 (rank : 84)	NC score	0.439069 (rank : 80)
Query Neighborhood Hits	376	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SH3G1_MOUSE
θ value	2.44474e-05 (rank : 85)	NC score	0.472251 (rank : 65)
Query Neighborhood Hits	376	Target Neighborhood Hits	291	Shared Neighborhood Hits	188
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CNN2_HUMAN
θ value	3.19293e-05 (rank : 86)	NC score	0.234874 (rank : 177)
Query Neighborhood Hits	376	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

SOS1_MOUSE
θ value	3.19293e-05 (rank : 87)	NC score	0.259905 (rank : 157)
Query Neighborhood Hits	376	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

LMO7_HUMAN
θ value	4.1701e-05 (rank : 88)	NC score	0.213792 (rank : 190)
Query Neighborhood Hits	376	Target Neighborhood Hits	507	Shared Neighborhood Hits	92
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

M3K9_HUMAN
θ value	4.1701e-05 (rank : 89)	NC score	0.152884 (rank : 240)
Query Neighborhood Hits	376	Target Neighborhood Hits	1123	Shared Neighborhood Hits	194
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MYO1F_MOUSE
θ value	5.44631e-05 (rank : 90)	NC score	0.235660 (rank : 175)
Query Neighborhood Hits	376	Target Neighborhood Hits	262	Shared Neighborhood Hits	199
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	5.44631e-05 (rank : 91)	NC score	0.510281 (rank : 40)
Query Neighborhood Hits	376	Target Neighborhood Hits	198	Shared Neighborhood Hits	159
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SHAN2_MOUSE
θ value	5.44631e-05 (rank : 92)	NC score	0.268327 (rank : 152)
Query Neighborhood Hits	376	Target Neighborhood Hits	446	Shared Neighborhood Hits	113
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

MYO1F_HUMAN
θ value	7.1131e-05 (rank : 93)	NC score	0.236392 (rank : 174)
Query Neighborhood Hits	376	Target Neighborhood Hits	275	Shared Neighborhood Hits	199
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

HCK_HUMAN
θ value	9.29e-05 (rank : 94)	NC score	0.142908 (rank : 253)
Query Neighborhood Hits	376	Target Neighborhood Hits	1035	Shared Neighborhood Hits	173
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

OBSCN_HUMAN
θ value	9.29e-05 (rank : 95)	NC score	0.107403 (rank : 297)
Query Neighborhood Hits	376	Target Neighborhood Hits	1931	Shared Neighborhood Hits	107
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

GRAP_HUMAN
θ value	0.000121331 (rank : 96)	NC score	0.488604 (rank : 51)
Query Neighborhood Hits	376	Target Neighborhood Hits	307	Shared Neighborhood Hits	189
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCF1_MOUSE
θ value	0.000121331 (rank : 97)	NC score	0.496469 (rank : 47)
Query Neighborhood Hits	376	Target Neighborhood Hits	198	Shared Neighborhood Hits	168
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

AHI1_MOUSE
θ value	0.000158464 (rank : 98)	NC score	0.358761 (rank : 117)
Query Neighborhood Hits	376	Target Neighborhood Hits	496	Shared Neighborhood Hits	186
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

M3K11_HUMAN
θ value	0.000158464 (rank : 99)	NC score	0.154442 (rank : 238)
Query Neighborhood Hits	376	Target Neighborhood Hits	1136	Shared Neighborhood Hits	186
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3KL4_HUMAN
θ value	0.000158464 (rank : 100)	NC score	0.163417 (rank : 230)
Query Neighborhood Hits	376	Target Neighborhood Hits	1087	Shared Neighborhood Hits	198
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SRC8_HUMAN
θ value	0.000158464 (rank : 101)	NC score	0.499021 (rank : 45)
Query Neighborhood Hits	376	Target Neighborhood Hits	269	Shared Neighborhood Hits	188
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	0.000158464 (rank : 102)	NC score	0.494162 (rank : 48)
Query Neighborhood Hits	376	Target Neighborhood Hits	292	Shared Neighborhood Hits	185
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

FGR_HUMAN
θ value	0.00020696 (rank : 103)	NC score	0.170406 (rank : 221)
Query Neighborhood Hits	376	Target Neighborhood Hits	1067	Shared Neighborhood Hits	180
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GRAP2_MOUSE
θ value	0.00020696 (rank : 104)	NC score	0.490927 (rank : 50)
Query Neighborhood Hits	376	Target Neighborhood Hits	297	Shared Neighborhood Hits	183
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PPIP1_MOUSE
θ value	0.00020696 (rank : 105)	NC score	0.445375 (rank : 76)
Query Neighborhood Hits	376	Target Neighborhood Hits	377	Shared Neighborhood Hits	221
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ALS2_HUMAN
θ value	0.000270298 (rank : 106)	NC score	0.106530 (rank : 301)
Query Neighborhood Hits	376	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

SPTA2_HUMAN
θ value	0.000270298 (rank : 107)	NC score	0.253162 (rank : 161)
Query Neighborhood Hits	376	Target Neighborhood Hits	888	Shared Neighborhood Hits	244
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAM2_MOUSE
θ value	0.000270298 (rank : 108)	NC score	0.456239 (rank : 70)
Query Neighborhood Hits	376	Target Neighborhood Hits	285	Shared Neighborhood Hits	183
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAC_HUMAN
θ value	0.00035302 (rank : 109)	NC score	0.476151 (rank : 62)
Query Neighborhood Hits	376	Target Neighborhood Hits	276	Shared Neighborhood Hits	187
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BCR_HUMAN
θ value	0.000461057 (rank : 110)	NC score	0.279207 (rank : 145)
Query Neighborhood Hits	376	Target Neighborhood Hits	204	Shared Neighborhood Hits	60
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

GRAP2_HUMAN
θ value	0.000461057 (rank : 111)	NC score	0.485758 (rank : 53)
Query Neighborhood Hits	376	Target Neighborhood Hits	304	Shared Neighborhood Hits	185
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PPIP1_HUMAN
θ value	0.000461057 (rank : 112)	NC score	0.446002 (rank : 74)
Query Neighborhood Hits	376	Target Neighborhood Hits	389	Shared Neighborhood Hits	224
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

STAM1_HUMAN
θ value	0.000461057 (rank : 113)	NC score	0.461953 (rank : 67)
Query Neighborhood Hits	376	Target Neighborhood Hits	271	Shared Neighborhood Hits	187
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

CSKP_HUMAN
θ value	0.000602161 (rank : 114)	NC score	0.075348 (rank : 356)
Query Neighborhood Hits	376	Target Neighborhood Hits	1022	Shared Neighborhood Hits	123
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

GNRP_MOUSE
θ value	0.000602161 (rank : 115)	NC score	0.339562 (rank : 122)
Query Neighborhood Hits	376	Target Neighborhood Hits	191	Shared Neighborhood Hits	62
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RHG26_HUMAN
θ value	0.000602161 (rank : 116)	NC score	0.241711 (rank : 166)
Query Neighborhood Hits	376	Target Neighborhood Hits	281	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

STAC_MOUSE
θ value	0.000602161 (rank : 117)	NC score	0.466374 (rank : 66)
Query Neighborhood Hits	376	Target Neighborhood Hits	268	Shared Neighborhood Hits	182
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

HCLS1_HUMAN
θ value	0.000786445 (rank : 118)	NC score	0.483962 (rank : 57)
Query Neighborhood Hits	376	Target Neighborhood Hits	358	Shared Neighborhood Hits	165
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	0.000786445 (rank : 119)	NC score	0.484666 (rank : 54)
Query Neighborhood Hits	376	Target Neighborhood Hits	329	Shared Neighborhood Hits	166
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABL1_HUMAN
θ value	0.00102713 (rank : 120)	NC score	0.122603 (rank : 277)
Query Neighborhood Hits	376	Target Neighborhood Hits	1220	Shared Neighborhood Hits	137
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	0.00102713 (rank : 121)	NC score	0.122704 (rank : 275)
Query Neighborhood Hits	376	Target Neighborhood Hits	1178	Shared Neighborhood Hits	134
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

DDEF2_HUMAN
θ value	0.00102713 (rank : 122)	NC score	0.227706 (rank : 183)
Query Neighborhood Hits	376	Target Neighborhood Hits	599	Shared Neighborhood Hits	165
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.00102713 (rank : 123)	NC score	0.230878 (rank : 179)
Query Neighborhood Hits	376	Target Neighborhood Hits	625	Shared Neighborhood Hits	160
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

HCK_MOUSE
θ value	0.00102713 (rank : 124)	NC score	0.145509 (rank : 250)
Query Neighborhood Hits	376	Target Neighborhood Hits	1029	Shared Neighborhood Hits	172
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ABI3_HUMAN
θ value	0.00134147 (rank : 125)	NC score	0.449639 (rank : 71)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BLK_MOUSE
θ value	0.00134147 (rank : 126)	NC score	0.131103 (rank : 267)
Query Neighborhood Hits	376	Target Neighborhood Hits	992	Shared Neighborhood Hits	132
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

STAM1_MOUSE
θ value	0.00134147 (rank : 127)	NC score	0.459722 (rank : 68)
Query Neighborhood Hits	376	Target Neighborhood Hits	273	Shared Neighborhood Hits	183
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG5_HUMAN
θ value	0.00175202 (rank : 128)	NC score	0.429352 (rank : 86)
Query Neighborhood Hits	376	Target Neighborhood Hits	172	Shared Neighborhood Hits	131
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGG_MOUSE
θ value	0.00175202 (rank : 129)	NC score	0.403369 (rank : 97)
Query Neighborhood Hits	376	Target Neighborhood Hits	152	Shared Neighborhood Hits	98
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

GNRP_HUMAN
θ value	0.00175202 (rank : 130)	NC score	0.307615 (rank : 135)
Query Neighborhood Hits	376	Target Neighborhood Hits	239	Shared Neighborhood Hits	70
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

NEBU_HUMAN
θ value	0.00175202 (rank : 131)	NC score	0.313621 (rank : 131)
Query Neighborhood Hits	376	Target Neighborhood Hits	420	Shared Neighborhood Hits	180
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

RIMB2_HUMAN
θ value	0.00175202 (rank : 132)	NC score	0.313197 (rank : 132)
Query Neighborhood Hits	376	Target Neighborhood Hits	263	Shared Neighborhood Hits	123
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

STAC3_HUMAN
θ value	0.00175202 (rank : 133)	NC score	0.431596 (rank : 85)
Query Neighborhood Hits	376	Target Neighborhood Hits	228	Shared Neighborhood Hits	152
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.00175202 (rank : 134)	NC score	0.434371 (rank : 82)
Query Neighborhood Hits	376	Target Neighborhood Hits	232	Shared Neighborhood Hits	153
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CSK_HUMAN
θ value	0.00228821 (rank : 135)	NC score	0.127185 (rank : 271)
Query Neighborhood Hits	376	Target Neighborhood Hits	1009	Shared Neighborhood Hits	141
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.00228821 (rank : 136)	NC score	0.127526 (rank : 270)
Query Neighborhood Hits	376	Target Neighborhood Hits	1009	Shared Neighborhood Hits	141
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	0.00228821 (rank : 137)	NC score	0.360201 (rank : 116)
Query Neighborhood Hits	376	Target Neighborhood Hits	235	Shared Neighborhood Hits	133
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

M3K10_HUMAN
θ value	0.00228821 (rank : 138)	NC score	0.135438 (rank : 258)
Query Neighborhood Hits	376	Target Neighborhood Hits	1071	Shared Neighborhood Hits	180
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

STAM2_HUMAN
θ value	0.00228821 (rank : 139)	NC score	0.445867 (rank : 75)
Query Neighborhood Hits	376	Target Neighborhood Hits	288	Shared Neighborhood Hits	181
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

YES_MOUSE
θ value	0.00228821 (rank : 140)	NC score	0.165203 (rank : 228)
Query Neighborhood Hits	376	Target Neighborhood Hits	1052	Shared Neighborhood Hits	181
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

DDEF1_MOUSE
θ value	0.00298849 (rank : 141)	NC score	0.240841 (rank : 169)
Query Neighborhood Hits	376	Target Neighborhood Hits	592	Shared Neighborhood Hits	154
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

NCF4_MOUSE
θ value	0.00298849 (rank : 142)	NC score	0.474597 (rank : 64)
Query Neighborhood Hits	376	Target Neighborhood Hits	177	Shared Neighborhood Hits	139
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

RIMB2_MOUSE
θ value	0.00298849 (rank : 143)	NC score	0.310738 (rank : 134)
Query Neighborhood Hits	376	Target Neighborhood Hits	246	Shared Neighborhood Hits	119
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CRKL_HUMAN
θ value	0.00390308 (rank : 144)	NC score	0.433715 (rank : 83)
Query Neighborhood Hits	376	Target Neighborhood Hits	313	Shared Neighborhood Hits	183
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	0.00390308 (rank : 145)	NC score	0.427654 (rank : 89)
Query Neighborhood Hits	376	Target Neighborhood Hits	307	Shared Neighborhood Hits	179
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

RIMB1_MOUSE
θ value	0.00390308 (rank : 146)	NC score	0.200005 (rank : 198)
Query Neighborhood Hits	376	Target Neighborhood Hits	1376	Shared Neighborhood Hits	236
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ABI3_MOUSE
θ value	0.00509761 (rank : 147)	NC score	0.443384 (rank : 79)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	147
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NEBL_HUMAN
θ value	0.00509761 (rank : 148)	NC score	0.368200 (rank : 114)
Query Neighborhood Hits	376	Target Neighborhood Hits	457	Shared Neighborhood Hits	212
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PTK6_MOUSE
θ value	0.00509761 (rank : 149)	NC score	0.129230 (rank : 269)
Query Neighborhood Hits	376	Target Neighborhood Hits	1026	Shared Neighborhood Hits	155
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SAMN1_HUMAN
θ value	0.00509761 (rank : 150)	NC score	0.167337 (rank : 225)
Query Neighborhood Hits	376	Target Neighborhood Hits	74	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SRC_HUMAN
θ value	0.00509761 (rank : 151)	NC score	0.161192 (rank : 233)
Query Neighborhood Hits	376	Target Neighborhood Hits	1058	Shared Neighborhood Hits	184
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

CSKP_MOUSE
θ value	0.00665767 (rank : 152)	NC score	0.072260 (rank : 372)
Query Neighborhood Hits	376	Target Neighborhood Hits	1027	Shared Neighborhood Hits	129
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

LASP1_MOUSE
θ value	0.00665767 (rank : 153)	NC score	0.378342 (rank : 111)
Query Neighborhood Hits	376	Target Neighborhood Hits	297	Shared Neighborhood Hits	154
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCF4_HUMAN
θ value	0.00665767 (rank : 154)	NC score	0.458387 (rank : 69)
Query Neighborhood Hits	376	Target Neighborhood Hits	161	Shared Neighborhood Hits	126
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

BI2L1_HUMAN
θ value	0.00869519 (rank : 155)	NC score	0.207713 (rank : 192)
Query Neighborhood Hits	376	Target Neighborhood Hits	156	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BTK_HUMAN
θ value	0.00869519 (rank : 156)	NC score	0.146570 (rank : 248)
Query Neighborhood Hits	376	Target Neighborhood Hits	1026	Shared Neighborhood Hits	178
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

IASPP_MOUSE
θ value	0.00869519 (rank : 157)	NC score	0.238464 (rank : 172)
Query Neighborhood Hits	376	Target Neighborhood Hits	1024	Shared Neighborhood Hits	166
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	0.00869519 (rank : 158)	NC score	0.379935 (rank : 110)
Query Neighborhood Hits	376	Target Neighborhood Hits	293	Shared Neighborhood Hits	154
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

BI2L1_MOUSE
θ value	0.0113563 (rank : 159)	NC score	0.169238 (rank : 224)
Query Neighborhood Hits	376	Target Neighborhood Hits	197	Shared Neighborhood Hits	71
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

LRCH1_HUMAN
θ value	0.0113563 (rank : 160)	NC score	0.097730 (rank : 315)
Query Neighborhood Hits	376	Target Neighborhood Hits	266	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y2L9, Q7Z5F6, Q7Z5F7	Gene names	LRCH1, CHDC1, KIAA1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81).

PACN2_MOUSE
θ value	0.0113563 (rank : 161)	NC score	0.405306 (rank : 96)
Query Neighborhood Hits	376	Target Neighborhood Hits	382	Shared Neighborhood Hits	215
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PTK6_HUMAN
θ value	0.0113563 (rank : 162)	NC score	0.125644 (rank : 273)
Query Neighborhood Hits	376	Target Neighborhood Hits	1020	Shared Neighborhood Hits	160
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

YES_HUMAN
θ value	0.0113563 (rank : 163)	NC score	0.163597 (rank : 229)
Query Neighborhood Hits	376	Target Neighborhood Hits	1059	Shared Neighborhood Hits	183
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

NCF2_HUMAN
θ value	0.0148317 (rank : 164)	NC score	0.514316 (rank : 38)
Query Neighborhood Hits	376	Target Neighborhood Hits	229	Shared Neighborhood Hits	166
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PACN2_HUMAN
θ value	0.0148317 (rank : 165)	NC score	0.407349 (rank : 95)
Query Neighborhood Hits	376	Target Neighborhood Hits	339	Shared Neighborhood Hits	214
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RIMB1_HUMAN
θ value	0.0148317 (rank : 166)	NC score	0.203459 (rank : 195)
Query Neighborhood Hits	376	Target Neighborhood Hits	1479	Shared Neighborhood Hits	230
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SPTA1_MOUSE
θ value	0.0148317 (rank : 167)	NC score	0.230645 (rank : 180)
Query Neighborhood Hits	376	Target Neighborhood Hits	675	Shared Neighborhood Hits	212
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ARHGC_HUMAN
θ value	0.0193708 (rank : 168)	NC score	0.305813 (rank : 136)
Query Neighborhood Hits	376	Target Neighborhood Hits	351	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CRK_MOUSE
θ value	0.0193708 (rank : 169)	NC score	0.422678 (rank : 91)
Query Neighborhood Hits	376	Target Neighborhood Hits	314	Shared Neighborhood Hits	184
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FGR_MOUSE
θ value	0.0193708 (rank : 170)	NC score	0.160552 (rank : 234)
Query Neighborhood Hits	376	Target Neighborhood Hits	1069	Shared Neighborhood Hits	181
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

PACN3_MOUSE
θ value	0.0193708 (rank : 171)	NC score	0.372294 (rank : 112)
Query Neighborhood Hits	376	Target Neighborhood Hits	380	Shared Neighborhood Hits	203
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

TAGL3_HUMAN
θ value	0.0193708 (rank : 172)	NC score	0.179750 (rank : 209)
Query Neighborhood Hits	376	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UI15, Q96A74	Gene names	TAGLN3, NP25
Domain Architecture
Description	Transgelin-3 (Neuronal protein NP25) (Neuronal protein 22) (NP22).

ARHGB_HUMAN
θ value	0.0252991 (rank : 173)	NC score	0.315368 (rank : 130)
Query Neighborhood Hits	376	Target Neighborhood Hits	375	Shared Neighborhood Hits	70
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

PACN1_MOUSE
θ value	0.0252991 (rank : 174)	NC score	0.381902 (rank : 109)
Query Neighborhood Hits	376	Target Neighborhood Hits	283	Shared Neighborhood Hits	185
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ABL2_HUMAN
θ value	0.0330416 (rank : 175)	NC score	0.117859 (rank : 283)
Query Neighborhood Hits	376	Target Neighborhood Hits	1045	Shared Neighborhood Hits	121
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ASPP1_MOUSE
θ value	0.0330416 (rank : 176)	NC score	0.241293 (rank : 167)
Query Neighborhood Hits	376	Target Neighborhood Hits	1244	Shared Neighborhood Hits	220
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BLK_HUMAN
θ value	0.0330416 (rank : 177)	NC score	0.131297 (rank : 266)
Query Neighborhood Hits	376	Target Neighborhood Hits	994	Shared Neighborhood Hits	142
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BTK_MOUSE
θ value	0.0330416 (rank : 178)	NC score	0.139719 (rank : 256)
Query Neighborhood Hits	376	Target Neighborhood Hits	1017	Shared Neighborhood Hits	168
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

NOXO1_MOUSE
θ value	0.0330416 (rank : 179)	NC score	0.320496 (rank : 126)
Query Neighborhood Hits	376	Target Neighborhood Hits	114	Shared Neighborhood Hits	100
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PACN1_HUMAN
θ value	0.0330416 (rank : 180)	NC score	0.385514 (rank : 104)
Query Neighborhood Hits	376	Target Neighborhood Hits	320	Shared Neighborhood Hits	194
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN3_HUMAN
θ value	0.0330416 (rank : 181)	NC score	0.371521 (rank : 113)
Query Neighborhood Hits	376	Target Neighborhood Hits	385	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

CRK_HUMAN
θ value	0.0431538 (rank : 182)	NC score	0.416769 (rank : 92)
Query Neighborhood Hits	376	Target Neighborhood Hits	308	Shared Neighborhood Hits	184
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PEX13_HUMAN
θ value	0.0431538 (rank : 183)	NC score	0.324343 (rank : 124)
Query Neighborhood Hits	376	Target Neighborhood Hits	128	Shared Neighborhood Hits	110
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SPTA1_HUMAN
θ value	0.0431538 (rank : 184)	NC score	0.222721 (rank : 185)
Query Neighborhood Hits	376	Target Neighborhood Hits	748	Shared Neighborhood Hits	231
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ANM2_MOUSE
θ value	0.0563607 (rank : 185)	NC score	0.266123 (rank : 154)
Query Neighborhood Hits	376	Target Neighborhood Hits	175	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHGC_MOUSE
θ value	0.0563607 (rank : 186)	NC score	0.295784 (rank : 138)
Query Neighborhood Hits	376	Target Neighborhood Hits	344	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ASPP1_HUMAN
θ value	0.0563607 (rank : 187)	NC score	0.242003 (rank : 165)
Query Neighborhood Hits	376	Target Neighborhood Hits	956	Shared Neighborhood Hits	215
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

LYN_HUMAN
θ value	0.0563607 (rank : 188)	NC score	0.134561 (rank : 261)
Query Neighborhood Hits	376	Target Neighborhood Hits	1022	Shared Neighborhood Hits	157
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SRC_MOUSE
θ value	0.0563607 (rank : 189)	NC score	0.143202 (rank : 252)
Query Neighborhood Hits	376	Target Neighborhood Hits	1033	Shared Neighborhood Hits	164
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TAGL_MOUSE
θ value	0.0563607 (rank : 190)	NC score	0.179723 (rank : 210)
Query Neighborhood Hits	376	Target Neighborhood Hits	33	Shared Neighborhood Hits	29
SwissProt Accessions	P37804, Q545W0	Gene names	Tagln, Sm22, Sm22a
Domain Architecture
Description	Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (Actin- associated protein p27).

ANM2_HUMAN
θ value	0.0736092 (rank : 191)	NC score	0.281856 (rank : 144)
Query Neighborhood Hits	376	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHGG_HUMAN
θ value	0.0736092 (rank : 192)	NC score	0.383356 (rank : 107)
Query Neighborhood Hits	376	Target Neighborhood Hits	129	Shared Neighborhood Hits	86
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BCAR1_HUMAN
θ value	0.0736092 (rank : 193)	NC score	0.315685 (rank : 129)
Query Neighborhood Hits	376	Target Neighborhood Hits	554	Shared Neighborhood Hits	162
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	0.0736092 (rank : 194)	NC score	0.319672 (rank : 128)
Query Neighborhood Hits	376	Target Neighborhood Hits	438	Shared Neighborhood Hits	160
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

FGD6_MOUSE
θ value	0.0736092 (rank : 195)	NC score	0.319987 (rank : 127)
Query Neighborhood Hits	376	Target Neighborhood Hits	282	Shared Neighborhood Hits	63
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SAMN1_MOUSE
θ value	0.0736092 (rank : 196)	NC score	0.149139 (rank : 245)
Query Neighborhood Hits	376	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

TAGL3_MOUSE
θ value	0.0736092 (rank : 197)	NC score	0.173697 (rank : 215)
Query Neighborhood Hits	376	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1Q8	Gene names	Tagln3, Np25
Domain Architecture
Description	Transgelin-3 (Neuronal protein NP25).

DBNL_HUMAN
θ value	0.0961366 (rank : 198)	NC score	0.391915 (rank : 99)
Query Neighborhood Hits	376	Target Neighborhood Hits	244	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.0961366 (rank : 199)	NC score	0.387616 (rank : 102)
Query Neighborhood Hits	376	Target Neighborhood Hits	306	Shared Neighborhood Hits	154
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ASPP2_HUMAN
θ value	0.125558 (rank : 200)	NC score	0.207014 (rank : 193)
Query Neighborhood Hits	376	Target Neighborhood Hits	1156	Shared Neighborhood Hits	220
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

CASL_MOUSE
θ value	0.125558 (rank : 201)	NC score	0.293856 (rank : 140)
Query Neighborhood Hits	376	Target Neighborhood Hits	225	Shared Neighborhood Hits	144
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CCD46_MOUSE
θ value	0.125558 (rank : 202)	NC score	0.074894 (rank : 358)
Query Neighborhood Hits	376	Target Neighborhood Hits	1405	Shared Neighborhood Hits	130
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

LRCH2_HUMAN
θ value	0.125558 (rank : 203)	NC score	0.085523 (rank : 329)
Query Neighborhood Hits	376	Target Neighborhood Hits	315	Shared Neighborhood Hits	35
SwissProt Accessions	Q5VUJ6, Q9HA88, Q9P233	Gene names	LRCH2, KIAA1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

LRCH3_HUMAN
θ value	0.125558 (rank : 204)	NC score	0.082451 (rank : 338)
Query Neighborhood Hits	376	Target Neighborhood Hits	270	Shared Neighborhood Hits	31
SwissProt Accessions	Q96II8, Q96FP9, Q9NT52	Gene names	LRCH3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

LYN_MOUSE
θ value	0.125558 (rank : 205)	NC score	0.133334 (rank : 264)
Query Neighborhood Hits	376	Target Neighborhood Hits	1023	Shared Neighborhood Hits	156
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ROCK2_MOUSE
θ value	0.125558 (rank : 206)	NC score	0.056653 (rank : 522)
Query Neighborhood Hits	376	Target Neighborhood Hits	2072	Shared Neighborhood Hits	152
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SASH1_MOUSE
θ value	0.125558 (rank : 207)	NC score	0.140785 (rank : 254)
Query Neighborhood Hits	376	Target Neighborhood Hits	263	Shared Neighborhood Hits	58
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

TAGL_HUMAN
θ value	0.125558 (rank : 208)	NC score	0.178356 (rank : 211)
Query Neighborhood Hits	376	Target Neighborhood Hits	32	Shared Neighborhood Hits	29
SwissProt Accessions	Q01995, O15542	Gene names	TAGLN, SM22, WS3-10
Domain Architecture
Description	Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (WS3-10) (22 kDa actin-binding protein).

TCGAP_MOUSE
θ value	0.125558 (rank : 209)	NC score	0.200115 (rank : 197)
Query Neighborhood Hits	376	Target Neighborhood Hits	409	Shared Neighborhood Hits	124
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ABR_HUMAN
θ value	0.163984 (rank : 210)	NC score	0.260760 (rank : 156)
Query Neighborhood Hits	376	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

CASL_HUMAN
θ value	0.163984 (rank : 211)	NC score	0.293335 (rank : 141)
Query Neighborhood Hits	376	Target Neighborhood Hits	259	Shared Neighborhood Hits	145
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

IASPP_HUMAN
θ value	0.163984 (rank : 212)	NC score	0.248920 (rank : 162)
Query Neighborhood Hits	376	Target Neighborhood Hits	688	Shared Neighborhood Hits	157
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LRCH1_MOUSE
θ value	0.163984 (rank : 213)	NC score	0.088960 (rank : 326)
Query Neighborhood Hits	376	Target Neighborhood Hits	264	Shared Neighborhood Hits	37
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

LRCH2_MOUSE
θ value	0.163984 (rank : 214)	NC score	0.083358 (rank : 333)
Query Neighborhood Hits	376	Target Neighborhood Hits	287	Shared Neighborhood Hits	30
SwissProt Accessions	Q3UMG5, Q7TNP9, Q80TC9	Gene names	Lrch2, Kiaa1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

RNF8_MOUSE
θ value	0.163984 (rank : 215)	NC score	0.037884 (rank : 678)
Query Neighborhood Hits	376	Target Neighborhood Hits	618	Shared Neighborhood Hits	71
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

SASH1_HUMAN
θ value	0.163984 (rank : 216)	NC score	0.146084 (rank : 249)
Query Neighborhood Hits	376	Target Neighborhood Hits	292	Shared Neighborhood Hits	64
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SLY_HUMAN
θ value	0.163984 (rank : 217)	NC score	0.187517 (rank : 205)
Query Neighborhood Hits	376	Target Neighborhood Hits	81	Shared Neighborhood Hits	56
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

STS2_HUMAN
θ value	0.163984 (rank : 218)	NC score	0.194778 (rank : 202)
Query Neighborhood Hits	376	Target Neighborhood Hits	108	Shared Neighborhood Hits	84
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

CCD91_HUMAN
θ value	0.21417 (rank : 219)	NC score	0.073858 (rank : 362)
Query Neighborhood Hits	376	Target Neighborhood Hits	868	Shared Neighborhood Hits	99
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

LRCH4_MOUSE
θ value	0.21417 (rank : 220)	NC score	0.074234 (rank : 361)
Query Neighborhood Hits	376	Target Neighborhood Hits	302	Shared Neighborhood Hits	33
SwissProt Accessions	Q921G6	Gene names	Lrch4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4.

MPP6_MOUSE
θ value	0.21417 (rank : 221)	NC score	0.118714 (rank : 282)
Query Neighborhood Hits	376	Target Neighborhood Hits	187	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

PEX13_MOUSE
θ value	0.21417 (rank : 222)	NC score	0.322690 (rank : 125)
Query Neighborhood Hits	376	Target Neighborhood Hits	126	Shared Neighborhood Hits	113
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SLY_MOUSE
θ value	0.21417 (rank : 223)	NC score	0.203419 (rank : 196)
Query Neighborhood Hits	376	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SYCP1_MOUSE
θ value	0.21417 (rank : 224)	NC score	0.070245 (rank : 379)
Query Neighborhood Hits	376	Target Neighborhood Hits	1456	Shared Neighborhood Hits	125
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CCD46_HUMAN
θ value	0.279714 (rank : 225)	NC score	0.077655 (rank : 347)
Query Neighborhood Hits	376	Target Neighborhood Hits	1430	Shared Neighborhood Hits	128
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

FNBP2_HUMAN
θ value	0.279714 (rank : 226)	NC score	0.223931 (rank : 184)
Query Neighborhood Hits	376	Target Neighborhood Hits	432	Shared Neighborhood Hits	176
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

LAMA5_HUMAN
θ value	0.279714 (rank : 227)	NC score	0.012372 (rank : 696)
Query Neighborhood Hits	376	Target Neighborhood Hits	976	Shared Neighborhood Hits	62
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LRCH3_MOUSE
θ value	0.279714 (rank : 228)	NC score	0.081831 (rank : 340)
Query Neighborhood Hits	376	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

ROCK2_HUMAN
θ value	0.279714 (rank : 229)	NC score	0.054414 (rank : 565)
Query Neighborhood Hits	376	Target Neighborhood Hits	2073	Shared Neighborhood Hits	155
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SMC1A_HUMAN
θ value	0.279714 (rank : 230)	NC score	0.065515 (rank : 413)
Query Neighborhood Hits	376	Target Neighborhood Hits	1346	Shared Neighborhood Hits	123
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	0.279714 (rank : 231)	NC score	0.065722 (rank : 409)
Query Neighborhood Hits	376	Target Neighborhood Hits	1384	Shared Neighborhood Hits	124
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SNX18_MOUSE
θ value	0.279714 (rank : 232)	NC score	0.270351 (rank : 150)
Query Neighborhood Hits	376	Target Neighborhood Hits	198	Shared Neighborhood Hits	124
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

AMPH_MOUSE
θ value	0.365318 (rank : 233)	NC score	0.146784 (rank : 247)
Query Neighborhood Hits	376	Target Neighborhood Hits	291	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BPAEA_HUMAN
θ value	0.365318 (rank : 234)	NC score	0.061968 (rank : 445)
Query Neighborhood Hits	376	Target Neighborhood Hits	1369	Shared Neighborhood Hits	119
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

EPS8_HUMAN
θ value	0.365318 (rank : 235)	NC score	0.186270 (rank : 206)
Query Neighborhood Hits	376	Target Neighborhood Hits	151	Shared Neighborhood Hits	104
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

HCN3_HUMAN
θ value	0.365318 (rank : 236)	NC score	0.011734 (rank : 698)
Query Neighborhood Hits	376	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

LRCH4_HUMAN
θ value	0.365318 (rank : 237)	NC score	0.071590 (rank : 375)
Query Neighborhood Hits	376	Target Neighborhood Hits	305	Shared Neighborhood Hits	26
SwissProt Accessions	O75427, Q8WV85, Q96ID0	Gene names	LRCH4, LRN, LRRN4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4 (Leucine-rich neuronal protein).

RHG04_HUMAN
θ value	0.365318 (rank : 238)	NC score	0.258809 (rank : 159)
Query Neighborhood Hits	376	Target Neighborhood Hits	307	Shared Neighborhood Hits	160
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRGP2_HUMAN
θ value	0.365318 (rank : 239)	NC score	0.228592 (rank : 182)
Query Neighborhood Hits	376	Target Neighborhood Hits	331	Shared Neighborhood Hits	164
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

TAGL2_HUMAN
θ value	0.365318 (rank : 240)	NC score	0.165886 (rank : 226)
Query Neighborhood Hits	376	Target Neighborhood Hits	35	Shared Neighborhood Hits	26
SwissProt Accessions	P37802, Q5JRQ6, Q5JRQ7, Q9BUH5, Q9H4P0	Gene names	TAGLN2, KIAA0120
Domain Architecture
Description	Transgelin-2 (SM22-alpha homolog).

ALO17_HUMAN
θ value	0.47712 (rank : 241)	NC score	0.037174 (rank : 679)
Query Neighborhood Hits	376	Target Neighborhood Hits	317	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCF4, Q69YK7, Q8IWF4, Q8IZX1, Q8IZX2, Q8N406	Gene names	KIAA1618, ALO17
Domain Architecture	No domain graphic available
Description	Protein ALO17 (ALK lymphoma oligomerization partner on chromosome 17).

ANR18_HUMAN
θ value	0.47712 (rank : 242)	NC score	0.044998 (rank : 675)
Query Neighborhood Hits	376	Target Neighborhood Hits	1106	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

EM55_HUMAN
θ value	0.47712 (rank : 243)	NC score	0.137390 (rank : 257)
Query Neighborhood Hits	376	Target Neighborhood Hits	228	Shared Neighborhood Hits	89
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	0.47712 (rank : 244)	NC score	0.133528 (rank : 263)
Query Neighborhood Hits	376	Target Neighborhood Hits	221	Shared Neighborhood Hits	88
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ES8L2_MOUSE
θ value	0.47712 (rank : 245)	NC score	0.193398 (rank : 203)
Query Neighborhood Hits	376	Target Neighborhood Hits	169	Shared Neighborhood Hits	118
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FRK_HUMAN
θ value	0.47712 (rank : 246)	NC score	0.133737 (rank : 262)
Query Neighborhood Hits	376	Target Neighborhood Hits	1058	Shared Neighborhood Hits	178
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LIN9_HUMAN
θ value	0.47712 (rank : 247)	NC score	0.034285 (rank : 680)
Query Neighborhood Hits	376	Target Neighborhood Hits	35	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TKA1, Q5U5L8, Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1	Gene names	LIN9, BARA, TGS
Domain Architecture	No domain graphic available
Description	Lin-9 homolog (huLin-9) (hLin-9) (Beta-subunit associated regulator of apoptosis) (Type I interferon receptor beta chain-associated protein) (TUDOR gene similar protein) (pRB-associated protein).

SRGP1_HUMAN
θ value	0.47712 (rank : 248)	NC score	0.220457 (rank : 187)
Query Neighborhood Hits	376	Target Neighborhood Hits	390	Shared Neighborhood Hits	170
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_MOUSE
θ value	0.47712 (rank : 249)	NC score	0.230572 (rank : 181)
Query Neighborhood Hits	376	Target Neighborhood Hits	324	Shared Neighborhood Hits	169
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

TAGL2_MOUSE
θ value	0.47712 (rank : 250)	NC score	0.165304 (rank : 227)
Query Neighborhood Hits	376	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVA4	Gene names	Tagln2
Domain Architecture
Description	Transgelin-2.

TEC_HUMAN
θ value	0.47712 (rank : 251)	NC score	0.115699 (rank : 286)
Query Neighborhood Hits	376	Target Neighborhood Hits	1006	Shared Neighborhood Hits	139
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

AMPE_HUMAN
θ value	0.62314 (rank : 252)	NC score	0.023933 (rank : 690)
Query Neighborhood Hits	376	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

ES8L2_HUMAN
θ value	0.62314 (rank : 253)	NC score	0.198782 (rank : 200)
Query Neighborhood Hits	376	Target Neighborhood Hits	193	Shared Neighborhood Hits	121
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FUT8_MOUSE
θ value	0.62314 (rank : 254)	NC score	0.113843 (rank : 288)
Query Neighborhood Hits	376	Target Neighborhood Hits	115	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

MYH9_MOUSE
θ value	0.62314 (rank : 255)	NC score	0.067657 (rank : 393)
Query Neighborhood Hits	376	Target Neighborhood Hits	1829	Shared Neighborhood Hits	141
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SNX18_HUMAN
θ value	0.62314 (rank : 256)	NC score	0.262325 (rank : 155)
Query Neighborhood Hits	376	Target Neighborhood Hits	207	Shared Neighborhood Hits	127
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SOS2_HUMAN
θ value	0.62314 (rank : 257)	NC score	0.218124 (rank : 189)
Query Neighborhood Hits	376	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

CENPE_HUMAN
θ value	0.813845 (rank : 258)	NC score	0.059220 (rank : 477)
Query Neighborhood Hits	376	Target Neighborhood Hits	2060	Shared Neighborhood Hits	147
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

EPS8_MOUSE
θ value	0.813845 (rank : 259)	NC score	0.184012 (rank : 208)
Query Neighborhood Hits	376	Target Neighborhood Hits	157	Shared Neighborhood Hits	118
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L3_MOUSE
θ value	0.813845 (rank : 260)	NC score	0.235105 (rank : 176)
Query Neighborhood Hits	376	Target Neighborhood Hits	168	Shared Neighborhood Hits	135
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

GRAP1_HUMAN
θ value	0.813845 (rank : 261)	NC score	0.061002 (rank : 455)
Query Neighborhood Hits	376	Target Neighborhood Hits	944	Shared Neighborhood Hits	106
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

LAMA2_MOUSE
θ value	0.813845 (rank : 262)	NC score	0.032592 (rank : 682)
Query Neighborhood Hits	376	Target Neighborhood Hits	1198	Shared Neighborhood Hits	94
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

MYH9_HUMAN
θ value	0.813845 (rank : 263)	NC score	0.069218 (rank : 383)
Query Neighborhood Hits	376	Target Neighborhood Hits	1762	Shared Neighborhood Hits	144
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RGNEF_MOUSE
θ value	0.813845 (rank : 264)	NC score	0.267669 (rank : 153)
Query Neighborhood Hits	376	Target Neighborhood Hits	641	Shared Neighborhood Hits	121
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SKIL_MOUSE
θ value	0.813845 (rank : 265)	NC score	0.059790 (rank : 467)
Query Neighborhood Hits	376	Target Neighborhood Hits	719	Shared Neighborhood Hits	93
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SNX9_HUMAN
θ value	0.813845 (rank : 266)	NC score	0.198803 (rank : 199)
Query Neighborhood Hits	376	Target Neighborhood Hits	148	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

STS1_MOUSE
θ value	0.813845 (rank : 267)	NC score	0.163049 (rank : 231)
Query Neighborhood Hits	376	Target Neighborhood Hits	104	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

AMPH_HUMAN
θ value	1.06291 (rank : 268)	NC score	0.150532 (rank : 241)
Query Neighborhood Hits	376	Target Neighborhood Hits	455	Shared Neighborhood Hits	111
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

EVPL_MOUSE
θ value	1.06291 (rank : 269)	NC score	0.059946 (rank : 464)
Query Neighborhood Hits	376	Target Neighborhood Hits	952	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

FUT8_HUMAN
θ value	1.06291 (rank : 270)	NC score	0.115848 (rank : 285)
Query Neighborhood Hits	376	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GOGA4_HUMAN
θ value	1.06291 (rank : 271)	NC score	0.069039 (rank : 385)
Query Neighborhood Hits	376	Target Neighborhood Hits	2034	Shared Neighborhood Hits	145
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GRAP1_MOUSE
θ value	1.06291 (rank : 272)	NC score	0.063160 (rank : 440)
Query Neighborhood Hits	376	Target Neighborhood Hits	1234	Shared Neighborhood Hits	114
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

LIN9_MOUSE
θ value	1.06291 (rank : 273)	NC score	0.031877 (rank : 683)
Query Neighborhood Hits	376	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C735, Q5TKA0, Q8C9D8	Gene names	Lin9, Bara, Tgs1
Domain Architecture	No domain graphic available
Description	Lin-9 homolog (mLin-9) (Type I interferon receptor beta chain- associated protein) (TUDOR gene similar 1 protein).

MPP6_HUMAN
θ value	1.06291 (rank : 274)	NC score	0.120576 (rank : 280)
Query Neighborhood Hits	376	Target Neighborhood Hits	180	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

SNX9_MOUSE
θ value	1.06291 (rank : 275)	NC score	0.176938 (rank : 213)
Query Neighborhood Hits	376	Target Neighborhood Hits	141	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

STS1_HUMAN
θ value	1.06291 (rank : 276)	NC score	0.161451 (rank : 232)
Query Neighborhood Hits	376	Target Neighborhood Hits	106	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

TCGAP_HUMAN
θ value	1.06291 (rank : 277)	NC score	0.176997 (rank : 212)
Query Neighborhood Hits	376	Target Neighborhood Hits	872	Shared Neighborhood Hits	128
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TEC_MOUSE
θ value	1.06291 (rank : 278)	NC score	0.111575 (rank : 293)
Query Neighborhood Hits	376	Target Neighborhood Hits	1006	Shared Neighborhood Hits	140
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEX14_MOUSE
θ value	1.06291 (rank : 279)	NC score	0.072306 (rank : 371)
Query Neighborhood Hits	376	Target Neighborhood Hits	1333	Shared Neighborhood Hits	111
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

HOOK2_MOUSE
θ value	1.38821 (rank : 280)	NC score	0.056282 (rank : 532)
Query Neighborhood Hits	376	Target Neighborhood Hits	736	Shared Neighborhood Hits	100
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

KMHN1_HUMAN
θ value	1.38821 (rank : 281)	NC score	0.058317 (rank : 492)
Query Neighborhood Hits	376	Target Neighborhood Hits	950	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

CAF1A_MOUSE
θ value	1.81305 (rank : 282)	NC score	0.061244 (rank : 451)
Query Neighborhood Hits	376	Target Neighborhood Hits	736	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

HXK4_HUMAN
θ value	1.81305 (rank : 283)	NC score	0.008808 (rank : 701)
Query Neighborhood Hits	376	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P35557, Q05810	Gene names	GCK
Domain Architecture
Description	Glucokinase (EC 2.7.1.2) (Hexokinase-4) (Hexokinase type IV) (HK IV) (HK4) (Hexokinase-D).

JIP2_MOUSE
θ value	1.81305 (rank : 284)	NC score	0.090477 (rank : 323)
Query Neighborhood Hits	376	Target Neighborhood Hits	144	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MPP2_MOUSE
θ value	1.81305 (rank : 285)	NC score	0.092617 (rank : 321)
Query Neighborhood Hits	376	Target Neighborhood Hits	189	Shared Neighborhood Hits	65
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MYH8_HUMAN
θ value	1.81305 (rank : 286)	NC score	0.067999 (rank : 390)
Query Neighborhood Hits	376	Target Neighborhood Hits	1610	Shared Neighborhood Hits	135
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SMC3_HUMAN
θ value	1.81305 (rank : 287)	NC score	0.069048 (rank : 384)
Query Neighborhood Hits	376	Target Neighborhood Hits	1186	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	1.81305 (rank : 288)	NC score	0.068931 (rank : 386)
Query Neighborhood Hits	376	Target Neighborhood Hits	1187	Shared Neighborhood Hits	112
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

DOCK1_HUMAN
θ value	2.36792 (rank : 289)	NC score	0.133154 (rank : 265)
Query Neighborhood Hits	376	Target Neighborhood Hits	191	Shared Neighborhood Hits	120
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

K1802_MOUSE
θ value	2.36792 (rank : 290)	NC score	0.007435 (rank : 704)
Query Neighborhood Hits	376	Target Neighborhood Hits	1596	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MYH7_HUMAN
θ value	2.36792 (rank : 291)	NC score	0.066193 (rank : 404)
Query Neighborhood Hits	376	Target Neighborhood Hits	1559	Shared Neighborhood Hits	127
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

PCNT_HUMAN
θ value	2.36792 (rank : 292)	NC score	0.068132 (rank : 389)
Query Neighborhood Hits	376	Target Neighborhood Hits	1551	Shared Neighborhood Hits	135
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PEPL_HUMAN
θ value	2.36792 (rank : 293)	NC score	0.055562 (rank : 549)
Query Neighborhood Hits	376	Target Neighborhood Hits	1141	Shared Neighborhood Hits	113
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

PEPL_MOUSE
θ value	2.36792 (rank : 294)	NC score	0.062233 (rank : 444)
Query Neighborhood Hits	376	Target Neighborhood Hits	1105	Shared Neighborhood Hits	117
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

REN3A_HUMAN
θ value	2.36792 (rank : 295)	NC score	0.039927 (rank : 677)
Query Neighborhood Hits	376	Target Neighborhood Hits	248	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H1J1, Q5T8C3, Q5T8C9, Q7Z6N3, Q86YK1, Q9BZI8	Gene names	UPF3A, RENT3A, UPF3
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3).

RF1M_HUMAN
θ value	2.36792 (rank : 296)	NC score	0.029653 (rank : 685)
Query Neighborhood Hits	376	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	O75570, Q5T6Y5, Q8IUQ6	Gene names	MTRF1
Domain Architecture
Description	Peptide chain release factor 1, mitochondrial precursor (MRF-1).

SLK_HUMAN
θ value	2.36792 (rank : 297)	NC score	0.046221 (rank : 673)
Query Neighborhood Hits	376	Target Neighborhood Hits	1775	Shared Neighborhood Hits	139
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

CAR14_HUMAN
θ value	3.0926 (rank : 298)	NC score	0.032650 (rank : 681)
Query Neighborhood Hits	376	Target Neighborhood Hits	449	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CN145_HUMAN
θ value	3.0926 (rank : 299)	NC score	0.058963 (rank : 482)
Query Neighborhood Hits	376	Target Neighborhood Hits	1196	Shared Neighborhood Hits	114
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

DMD_HUMAN
θ value	3.0926 (rank : 300)	NC score	0.058647 (rank : 487)
Query Neighborhood Hits	376	Target Neighborhood Hits	1135	Shared Neighborhood Hits	117
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

HOOK2_HUMAN
θ value	3.0926 (rank : 301)	NC score	0.052478 (rank : 607)
Query Neighborhood Hits	376	Target Neighborhood Hits	714	Shared Neighborhood Hits	92
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

MYH11_HUMAN
θ value	3.0926 (rank : 302)	NC score	0.068232 (rank : 388)
Query Neighborhood Hits	376	Target Neighborhood Hits	1806	Shared Neighborhood Hits	140
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
θ value	3.0926 (rank : 303)	NC score	0.066155 (rank : 406)
Query Neighborhood Hits	376	Target Neighborhood Hits	1777	Shared Neighborhood Hits	138
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH6_MOUSE
θ value	3.0926 (rank : 304)	NC score	0.066679 (rank : 399)
Query Neighborhood Hits	376	Target Neighborhood Hits	1501	Shared Neighborhood Hits	133
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

AZI1_MOUSE
θ value	4.03905 (rank : 305)	NC score	0.057070 (rank : 513)
Query Neighborhood Hits	376	Target Neighborhood Hits	990	Shared Neighborhood Hits	113
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

CDT1_MOUSE
θ value	4.03905 (rank : 306)	NC score	0.015736 (rank : 693)
Query Neighborhood Hits	376	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

CK5P2_HUMAN
θ value	4.03905 (rank : 307)	NC score	0.058158 (rank : 496)
Query Neighborhood Hits	376	Target Neighborhood Hits	1433	Shared Neighborhood Hits	127
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CROCC_HUMAN
θ value	4.03905 (rank : 308)	NC score	0.050934 (rank : 644)
Query Neighborhood Hits	376	Target Neighborhood Hits	1409	Shared Neighborhood Hits	117
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

DMD_MOUSE
θ value	4.03905 (rank : 309)	NC score	0.059076 (rank : 481)
Query Neighborhood Hits	376	Target Neighborhood Hits	1111	Shared Neighborhood Hits	111
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DSG1B_MOUSE
θ value	4.03905 (rank : 310)	NC score	-0.001870 (rank : 708)
Query Neighborhood Hits	376	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TSF1, Q7TQ60	Gene names	Dsg1b, Dsg5
Domain Architecture	No domain graphic available
Description	Desmoglein-1 beta precursor (Dsg1-beta) (Desmoglein-5).

IF2P_HUMAN
θ value	4.03905 (rank : 311)	NC score	0.049498 (rank : 669)
Query Neighborhood Hits	376	Target Neighborhood Hits	889	Shared Neighborhood Hits	100
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

JIP2_HUMAN
θ value	4.03905 (rank : 312)	NC score	0.088663 (rank : 327)
Query Neighborhood Hits	376	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MRCKB_MOUSE
θ value	4.03905 (rank : 313)	NC score	0.058627 (rank : 488)
Query Neighborhood Hits	376	Target Neighborhood Hits	2180	Shared Neighborhood Hits	165
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

RFIP4_HUMAN
θ value	4.03905 (rank : 314)	NC score	0.055713 (rank : 546)
Query Neighborhood Hits	376	Target Neighborhood Hits	785	Shared Neighborhood Hits	94
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RFIP4_MOUSE
θ value	4.03905 (rank : 315)	NC score	0.051949 (rank : 625)
Query Neighborhood Hits	376	Target Neighborhood Hits	708	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

SPN90_HUMAN
θ value	4.03905 (rank : 316)	NC score	0.176794 (rank : 214)
Query Neighborhood Hits	376	Target Neighborhood Hits	157	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

AMPE_MOUSE
θ value	5.27518 (rank : 317)	NC score	0.010100 (rank : 699)
Query Neighborhood Hits	376	Target Neighborhood Hits	35	Shared Neighborhood Hits	7
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

CCD13_HUMAN
θ value	5.27518 (rank : 318)	NC score	0.057050 (rank : 515)
Query Neighborhood Hits	376	Target Neighborhood Hits	721	Shared Neighborhood Hits	94
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CCD41_MOUSE
θ value	5.27518 (rank : 319)	NC score	0.061604 (rank : 447)
Query Neighborhood Hits	376	Target Neighborhood Hits	1399	Shared Neighborhood Hits	118
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CF182_HUMAN
θ value	5.27518 (rank : 320)	NC score	0.050756 (rank : 648)
Query Neighborhood Hits	376	Target Neighborhood Hits	474	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

CYTSA_MOUSE
θ value	5.27518 (rank : 321)	NC score	0.058022 (rank : 500)
Query Neighborhood Hits	376	Target Neighborhood Hits	1104	Shared Neighborhood Hits	113
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

DDX49_HUMAN
θ value	5.27518 (rank : 322)	NC score	0.004154 (rank : 706)
Query Neighborhood Hits	376	Target Neighborhood Hits	223	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

KIF11_HUMAN
θ value	5.27518 (rank : 323)	NC score	0.024465 (rank : 689)
Query Neighborhood Hits	376	Target Neighborhood Hits	583	Shared Neighborhood Hits	88
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

MPP9_HUMAN
θ value	5.27518 (rank : 324)	NC score	0.043814 (rank : 676)
Query Neighborhood Hits	376	Target Neighborhood Hits	529	Shared Neighborhood Hits	79
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

MYH10_HUMAN
θ value	5.27518 (rank : 325)	NC score	0.065722 (rank : 410)
Query Neighborhood Hits	376	Target Neighborhood Hits	1620	Shared Neighborhood Hits	136
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	5.27518 (rank : 326)	NC score	0.066086 (rank : 407)
Query Neighborhood Hits	376	Target Neighborhood Hits	1612	Shared Neighborhood Hits	136
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH4_MOUSE
θ value	5.27518 (rank : 327)	NC score	0.063683 (rank : 433)
Query Neighborhood Hits	376	Target Neighborhood Hits	1476	Shared Neighborhood Hits	133
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH6_HUMAN
θ value	5.27518 (rank : 328)	NC score	0.063929 (rank : 431)
Query Neighborhood Hits	376	Target Neighborhood Hits	1426	Shared Neighborhood Hits	125
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH8_MOUSE
θ value	5.27518 (rank : 329)	NC score	0.066794 (rank : 397)
Query Neighborhood Hits	376	Target Neighborhood Hits	1600	Shared Neighborhood Hits	133
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

NOC2L_MOUSE
θ value	5.27518 (rank : 330)	NC score	0.011934 (rank : 697)
Query Neighborhood Hits	376	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WV70, Q8VE16	Gene names	Noc2l
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

SAS6_MOUSE
θ value	5.27518 (rank : 331)	NC score	0.053739 (rank : 574)
Query Neighborhood Hits	376	Target Neighborhood Hits	931	Shared Neighborhood Hits	99
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

STIM1_HUMAN
θ value	5.27518 (rank : 332)	NC score	0.049616 (rank : 668)
Query Neighborhood Hits	376	Target Neighborhood Hits	665	Shared Neighborhood Hits	91
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STIM1_MOUSE
θ value	5.27518 (rank : 333)	NC score	0.047619 (rank : 672)
Query Neighborhood Hits	376	Target Neighborhood Hits	660	Shared Neighborhood Hits	90
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

SYNE2_HUMAN
θ value	5.27518 (rank : 334)	NC score	0.056349 (rank : 531)
Query Neighborhood Hits	376	Target Neighborhood Hits	1323	Shared Neighborhood Hits	119
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TRIPB_HUMAN
θ value	5.27518 (rank : 335)	NC score	0.067691 (rank : 392)
Query Neighborhood Hits	376	Target Neighborhood Hits	1587	Shared Neighborhood Hits	136
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ARHG2_MOUSE
θ value	6.88961 (rank : 336)	NC score	0.275272 (rank : 148)
Query Neighborhood Hits	376	Target Neighborhood Hits	120	Shared Neighborhood Hits	57
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

EFS_HUMAN
θ value	6.88961 (rank : 337)	NC score	0.277764 (rank : 147)
Query Neighborhood Hits	376	Target Neighborhood Hits	348	Shared Neighborhood Hits	147
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

FLIP1_HUMAN
θ value	6.88961 (rank : 338)	NC score	0.067053 (rank : 395)
Query Neighborhood Hits	376	Target Neighborhood Hits	1405	Shared Neighborhood Hits	136
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLIP1_MOUSE
θ value	6.88961 (rank : 339)	NC score	0.059895 (rank : 465)
Query Neighborhood Hits	376	Target Neighborhood Hits	1176	Shared Neighborhood Hits	122
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GCC2_MOUSE
θ value	6.88961 (rank : 340)	NC score	0.059702 (rank : 469)
Query Neighborhood Hits	376	Target Neighborhood Hits	1619	Shared Neighborhood Hits	126
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

HMMR_HUMAN
θ value	6.88961 (rank : 341)	NC score	0.058946 (rank : 483)
Query Neighborhood Hits	376	Target Neighborhood Hits	1082	Shared Neighborhood Hits	116
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

HOOK1_HUMAN
θ value	6.88961 (rank : 342)	NC score	0.059579 (rank : 472)
Query Neighborhood Hits	376	Target Neighborhood Hits	942	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

JIP1_MOUSE
θ value	6.88961 (rank : 343)	NC score	0.080054 (rank : 344)
Query Neighborhood Hits	376	Target Neighborhood Hits	259	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LAMB1_MOUSE
θ value	6.88961 (rank : 344)	NC score	0.014643 (rank : 694)
Query Neighborhood Hits	376	Target Neighborhood Hits	919	Shared Neighborhood Hits	82
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LUZP1_MOUSE
θ value	6.88961 (rank : 345)	NC score	0.059585 (rank : 471)
Query Neighborhood Hits	376	Target Neighborhood Hits	940	Shared Neighborhood Hits	107
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

MYH13_HUMAN
θ value	6.88961 (rank : 346)	NC score	0.065482 (rank : 415)
Query Neighborhood Hits	376	Target Neighborhood Hits	1504	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH2_HUMAN
θ value	6.88961 (rank : 347)	NC score	0.065407 (rank : 417)
Query Neighborhood Hits	376	Target Neighborhood Hits	1491	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYST4_MOUSE
θ value	6.88961 (rank : 348)	NC score	0.007869 (rank : 703)
Query Neighborhood Hits	376	Target Neighborhood Hits	416	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

NFM_HUMAN
θ value	6.88961 (rank : 349)	NC score	0.026982 (rank : 687)
Query Neighborhood Hits	376	Target Neighborhood Hits	1328	Shared Neighborhood Hits	111
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NFM_MOUSE
θ value	6.88961 (rank : 350)	NC score	0.026549 (rank : 688)
Query Neighborhood Hits	376	Target Neighborhood Hits	1159	Shared Neighborhood Hits	108
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

NGEF_MOUSE
θ value	6.88961 (rank : 351)	NC score	0.388556 (rank : 101)
Query Neighborhood Hits	376	Target Neighborhood Hits	228	Shared Neighborhood Hits	124
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	6.88961 (rank : 352)	NC score	0.231834 (rank : 178)
Query Neighborhood Hits	376	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NUMA1_HUMAN
θ value	6.88961 (rank : 353)	NC score	0.062238 (rank : 443)
Query Neighborhood Hits	376	Target Neighborhood Hits	1523	Shared Neighborhood Hits	128
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RFIP3_HUMAN
θ value	6.88961 (rank : 354)	NC score	0.059188 (rank : 478)
Query Neighborhood Hits	376	Target Neighborhood Hits	1055	Shared Neighborhood Hits	110
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

STK10_MOUSE
θ value	6.88961 (rank : 355)	NC score	0.052381 (rank : 613)
Query Neighborhood Hits	376	Target Neighborhood Hits	2132	Shared Neighborhood Hits	147
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TRI16_HUMAN
θ value	6.88961 (rank : 356)	NC score	0.008220 (rank : 702)
Query Neighborhood Hits	376	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

BICD1_MOUSE
θ value	8.99809 (rank : 357)	NC score	0.048117 (rank : 671)
Query Neighborhood Hits	376	Target Neighborhood Hits	837	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CD2L5_HUMAN
θ value	8.99809 (rank : 358)	NC score	0.028554 (rank : 686)
Query Neighborhood Hits	376	Target Neighborhood Hits	987	Shared Neighborhood Hits	46
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CM007_HUMAN
θ value	8.99809 (rank : 359)	NC score	0.019790 (rank : 692)
Query Neighborhood Hits	376	Target Neighborhood Hits	422	Shared Neighborhood Hits	58
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

CSKI1_HUMAN
θ value	8.99809 (rank : 360)	NC score	0.029882 (rank : 684)
Query Neighborhood Hits	376	Target Neighborhood Hits	997	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

EFS_MOUSE
θ value	8.99809 (rank : 361)	NC score	0.277846 (rank : 146)
Query Neighborhood Hits	376	Target Neighborhood Hits	389	Shared Neighborhood Hits	148
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ES8L3_HUMAN
θ value	8.99809 (rank : 362)	NC score	0.220632 (rank : 186)
Query Neighborhood Hits	376	Target Neighborhood Hits	206	Shared Neighborhood Hits	119
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

GOGB1_HUMAN
θ value	8.99809 (rank : 363)	NC score	0.064945 (rank : 422)
Query Neighborhood Hits	376	Target Neighborhood Hits	2297	Shared Neighborhood Hits	154
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

GORS2_MOUSE
θ value	8.99809 (rank : 364)	NC score	0.006297 (rank : 705)
Query Neighborhood Hits	376	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

HTF4_HUMAN
θ value	8.99809 (rank : 365)	NC score	0.003782 (rank : 707)
Query Neighborhood Hits	376	Target Neighborhood Hits	152	Shared Neighborhood Hits	9
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

MOES_HUMAN
θ value	8.99809 (rank : 366)	NC score	0.053713 (rank : 576)
Query Neighborhood Hits	376	Target Neighborhood Hits	892	Shared Neighborhood Hits	102
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MPP2_HUMAN
θ value	8.99809 (rank : 367)	NC score	0.089218 (rank : 325)
Query Neighborhood Hits	376	Target Neighborhood Hits	173	Shared Neighborhood Hits	65
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MYH1_HUMAN
θ value	8.99809 (rank : 368)	NC score	0.065433 (rank : 416)
Query Neighborhood Hits	376	Target Neighborhood Hits	1478	Shared Neighborhood Hits	130
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	8.99809 (rank : 369)	NC score	0.065303 (rank : 418)
Query Neighborhood Hits	376	Target Neighborhood Hits	1461	Shared Neighborhood Hits	129
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH3_HUMAN
θ value	8.99809 (rank : 370)	NC score	0.065634 (rank : 412)
Query Neighborhood Hits	376	Target Neighborhood Hits	1660	Shared Neighborhood Hits	137
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

NCOR1_MOUSE
θ value	8.99809 (rank : 371)	NC score	0.013388 (rank : 695)
Query Neighborhood Hits	376	Target Neighborhood Hits	521	Shared Neighborhood Hits	40
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

NCOR2_MOUSE
θ value	8.99809 (rank : 372)	NC score	0.023669 (rank : 691)
Query Neighborhood Hits	376	Target Neighborhood Hits	790	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NEST_HUMAN
θ value	8.99809 (rank : 373)	NC score	0.045602 (rank : 674)
Query Neighborhood Hits	376	Target Neighborhood Hits	1305	Shared Neighborhood Hits	101
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NPHP1_HUMAN
θ value	8.99809 (rank : 374)	NC score	0.299398 (rank : 137)
Query Neighborhood Hits	376	Target Neighborhood Hits	288	Shared Neighborhood Hits	169
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PO121_MOUSE
θ value	8.99809 (rank : 375)	NC score	0.009832 (rank : 700)
Query Neighborhood Hits	376	Target Neighborhood Hits	345	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

UACA_MOUSE
θ value	8.99809 (rank : 376)	NC score	0.048327 (rank : 670)
Query Neighborhood Hits	376	Target Neighborhood Hits	1620	Shared Neighborhood Hits	130
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

AATK_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.050542 (rank : 659)
Query Neighborhood Hits	376	Target Neighborhood Hits	942	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ACK1_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.064880 (rank : 423)
Query Neighborhood Hits	376	Target Neighborhood Hits	1140	Shared Neighborhood Hits	85
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.065060 (rank : 421)
Query Neighborhood Hits	376	Target Neighborhood Hits	1080	Shared Neighborhood Hits	89
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

AKAP9_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.058647 (rank : 486)
Query Neighborhood Hits	376	Target Neighborhood Hits	1710	Shared Neighborhood Hits	132
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ALK_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.052177 (rank : 619)
Query Neighborhood Hits	376	Target Neighborhood Hits	795	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.052451 (rank : 610)
Query Neighborhood Hits	376	Target Neighborhood Hits	811	Shared Neighborhood Hits	47
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ANR26_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.052454 (rank : 609)
Query Neighborhood Hits	376	Target Neighborhood Hits	1614	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANR26_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.050633 (rank : 653)
Query Neighborhood Hits	376	Target Neighborhood Hits	1554	Shared Neighborhood Hits	120
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

APS_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.106857 (rank : 299)
Query Neighborhood Hits	376	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.077100 (rank : 351)
Query Neighborhood Hits	376	Target Neighborhood Hits	134	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.287165 (rank : 142)
Query Neighborhood Hits	376	Target Neighborhood Hits	176	Shared Neighborhood Hits	52
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.253929 (rank : 160)
Query Neighborhood Hits	376	Target Neighborhood Hits	266	Shared Neighborhood Hits	50
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.259726 (rank : 158)
Query Neighborhood Hits	376	Target Neighborhood Hits	142	Shared Neighborhood Hits	60
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG8_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.435481 (rank : 81)
Query Neighborhood Hits	376	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGF_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.286568 (rank : 143)
Query Neighborhood Hits	376	Target Neighborhood Hits	214	Shared Neighborhood Hits	60
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

AZI1_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.061898 (rank : 446)
Query Neighborhood Hits	376	Target Neighborhood Hits	1000	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

BAIP2_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.121021 (rank : 279)
Query Neighborhood Hits	376	Target Neighborhood Hits	192	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.121789 (rank : 278)
Query Neighborhood Hits	376	Target Neighborhood Hits	185	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR3_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.064528 (rank : 425)
Query Neighborhood Hits	376	Target Neighborhood Hits	129	Shared Neighborhood Hits	37
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.064039 (rank : 430)
Query Neighborhood Hits	376	Target Neighborhood Hits	127	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BICD2_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.051683 (rank : 629)
Query Neighborhood Hits	376	Target Neighborhood Hits	856	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BIN1_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.115606 (rank : 287)
Query Neighborhood Hits	376	Target Neighborhood Hits	335	Shared Neighborhood Hits	92
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.116050 (rank : 284)
Query Neighborhood Hits	376	Target Neighborhood Hits	283	Shared Neighborhood Hits	96
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLNK_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.053842 (rank : 573)
Query Neighborhood Hits	376	Target Neighborhood Hits	228	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 401)	NC score	0.058618 (rank : 489)
Query Neighborhood Hits	376	Target Neighborhood Hits	296	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMX_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.072943 (rank : 367)
Query Neighborhood Hits	376	Target Neighborhood Hits	942	Shared Neighborhood Hits	61
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.072821 (rank : 368)
Query Neighborhood Hits	376	Target Neighborhood Hits	912	Shared Neighborhood Hits	61
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BPA1_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.056606 (rank : 523)
Query Neighborhood Hits	376	Target Neighborhood Hits	1477	Shared Neighborhood Hits	119
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BPAEA_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.057348 (rank : 509)
Query Neighborhood Hits	376	Target Neighborhood Hits	1480	Shared Neighborhood Hits	124
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BRE1B_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.050560 (rank : 658)
Query Neighborhood Hits	376	Target Neighborhood Hits	1040	Shared Neighborhood Hits	103
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

CARD9_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.053712 (rank : 577)
Query Neighborhood Hits	376	Target Neighborhood Hits	602	Shared Neighborhood Hits	91
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CASP_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.051420 (rank : 634)
Query Neighborhood Hits	376	Target Neighborhood Hits	1131	Shared Neighborhood Hits	115
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CASP_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.051566 (rank : 632)
Query Neighborhood Hits	376	Target Neighborhood Hits	1152	Shared Neighborhood Hits	118
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CCD19_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.054553 (rank : 562)
Query Neighborhood Hits	376	Target Neighborhood Hits	639	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CCD21_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.052969 (rank : 592)
Query Neighborhood Hits	376	Target Neighborhood Hits	1228	Shared Neighborhood Hits	118
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.054534 (rank : 563)
Query Neighborhood Hits	376	Target Neighborhood Hits	1135	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD39_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.050831 (rank : 647)
Query Neighborhood Hits	376	Target Neighborhood Hits	868	Shared Neighborhood Hits	98
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD39_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.052616 (rank : 605)
Query Neighborhood Hits	376	Target Neighborhood Hits	1026	Shared Neighborhood Hits	101
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD41_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.056739 (rank : 521)
Query Neighborhood Hits	376	Target Neighborhood Hits	1139	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD91_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.058038 (rank : 499)
Query Neighborhood Hits	376	Target Neighborhood Hits	699	Shared Neighborhood Hits	91
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CCD96_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.052740 (rank : 600)
Query Neighborhood Hits	376	Target Neighborhood Hits	704	Shared Neighborhood Hits	82
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CE152_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.065227 (rank : 419)
Query Neighborhood Hits	376	Target Neighborhood Hits	976	Shared Neighborhood Hits	111
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CE290_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.061121 (rank : 452)
Query Neighborhood Hits	376	Target Neighborhood Hits	1553	Shared Neighborhood Hits	125
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CENPF_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.066784 (rank : 398)
Query Neighborhood Hits	376	Target Neighborhood Hits	1932	Shared Neighborhood Hits	142
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CEP63_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.063300 (rank : 438)
Query Neighborhood Hits	376	Target Neighborhood Hits	1005	Shared Neighborhood Hits	112
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CF060_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.055767 (rank : 545)
Query Neighborhood Hits	376	Target Neighborhood Hits	1270	Shared Neighborhood Hits	112
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CHIN_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.077510 (rank : 348)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.078987 (rank : 345)
Query Neighborhood Hits	376	Target Neighborhood Hits	229	Shared Neighborhood Hits	53
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.075096 (rank : 357)
Query Neighborhood Hits	376	Target Neighborhood Hits	220	Shared Neighborhood Hits	50
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CI039_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.057862 (rank : 502)
Query Neighborhood Hits	376	Target Neighborhood Hits	1171	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CI093_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.060148 (rank : 462)
Query Neighborhood Hits	376	Target Neighborhood Hits	1088	Shared Neighborhood Hits	111
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CING_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.052239 (rank : 617)
Query Neighborhood Hits	376	Target Neighborhood Hits	1275	Shared Neighborhood Hits	120
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CING_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.052704 (rank : 603)
Query Neighborhood Hits	376	Target Neighborhood Hits	1432	Shared Neighborhood Hits	124
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CIP4_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.129905 (rank : 268)
Query Neighborhood Hits	376	Target Neighborhood Hits	374	Shared Neighborhood Hits	123
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CJ118_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.052473 (rank : 608)
Query Neighborhood Hits	376	Target Neighborhood Hits	1132	Shared Neighborhood Hits	110
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CK5P2_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.053488 (rank : 580)
Query Neighborhood Hits	376	Target Neighborhood Hits	1151	Shared Neighborhood Hits	111
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CNTRB_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.052779 (rank : 598)
Query Neighborhood Hits	376	Target Neighborhood Hits	1029	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP135_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.057149 (rank : 511)
Query Neighborhood Hits	376	Target Neighborhood Hits	1290	Shared Neighborhood Hits	113
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP135_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.057400 (rank : 507)
Query Neighborhood Hits	376	Target Neighborhood Hits	1278	Shared Neighborhood Hits	118
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP250_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.061525 (rank : 449)
Query Neighborhood Hits	376	Target Neighborhood Hits	1805	Shared Neighborhood Hits	135
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CP250_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.060692 (rank : 458)
Query Neighborhood Hits	376	Target Neighborhood Hits	1583	Shared Neighborhood Hits	132
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CT2NL_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.056049 (rank : 537)
Query Neighborhood Hits	376	Target Neighborhood Hits	1059	Shared Neighborhood Hits	109
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CTRO_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.053357 (rank : 581)
Query Neighborhood Hits	376	Target Neighborhood Hits	2344	Shared Neighborhood Hits	167
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CYLN2_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.052822 (rank : 596)
Query Neighborhood Hits	376	Target Neighborhood Hits	1004	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CYLN2_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.052213 (rank : 618)
Query Neighborhood Hits	376	Target Neighborhood Hits	1002	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

CYTSA_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.054407 (rank : 566)
Query Neighborhood Hits	376	Target Neighborhood Hits	1138	Shared Neighborhood Hits	118
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

DAPP1_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.126357 (rank : 272)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.125644 (rank : 274)
Query Neighborhood Hits	376	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDR1_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.051169 (rank : 637)
Query Neighborhood Hits	376	Target Neighborhood Hits	819	Shared Neighborhood Hits	41
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.051986 (rank : 623)
Query Neighborhood Hits	376	Target Neighborhood Hits	818	Shared Neighborhood Hits	41
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.050091 (rank : 666)
Query Neighborhood Hits	376	Target Neighborhood Hits	818	Shared Neighborhood Hits	44
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DESP_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.059664 (rank : 470)
Query Neighborhood Hits	376	Target Neighborhood Hits	1470	Shared Neighborhood Hits	130
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

DLG1_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.053992 (rank : 570)
Query Neighborhood Hits	376	Target Neighborhood Hits	290	Shared Neighborhood Hits	70
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.051040 (rank : 640)
Query Neighborhood Hits	376	Target Neighborhood Hits	285	Shared Neighborhood Hits	66
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG2_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.057107 (rank : 512)
Query Neighborhood Hits	376	Target Neighborhood Hits	279	Shared Neighborhood Hits	74
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.057362 (rank : 508)
Query Neighborhood Hits	376	Target Neighborhood Hits	271	Shared Neighborhood Hits	73
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.056370 (rank : 529)
Query Neighborhood Hits	376	Target Neighborhood Hits	269	Shared Neighborhood Hits	72
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.055965 (rank : 538)
Query Neighborhood Hits	376	Target Neighborhood Hits	274	Shared Neighborhood Hits	72
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG4_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.051003 (rank : 643)
Query Neighborhood Hits	376	Target Neighborhood Hits	286	Shared Neighborhood Hits	71
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG5_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.054476 (rank : 564)
Query Neighborhood Hits	376	Target Neighborhood Hits	1088	Shared Neighborhood Hits	145
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

EEA1_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.073038 (rank : 365)
Query Neighborhood Hits	376	Target Neighborhood Hits	1796	Shared Neighborhood Hits	138
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.081505 (rank : 341)
Query Neighborhood Hits	376	Target Neighborhood Hits	1637	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EP15R_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.069599 (rank : 382)
Query Neighborhood Hits	376	Target Neighborhood Hits	1083	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.071535 (rank : 376)
Query Neighborhood Hits	376	Target Neighborhood Hits	1135	Shared Neighborhood Hits	109
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.071177 (rank : 377)
Query Neighborhood Hits	376	Target Neighborhood Hits	1021	Shared Neighborhood Hits	110
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.073424 (rank : 364)
Query Neighborhood Hits	376	Target Neighborhood Hits	820	Shared Neighborhood Hits	100
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EPHA1_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.050863 (rank : 645)
Query Neighborhood Hits	376	Target Neighborhood Hits	997	Shared Neighborhood Hits	49
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.050335 (rank : 662)
Query Neighborhood Hits	376	Target Neighborhood Hits	958	Shared Neighborhood Hits	49
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHAA_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.051252 (rank : 636)
Query Neighborhood Hits	376	Target Neighborhood Hits	960	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.052440 (rank : 612)
Query Neighborhood Hits	376	Target Neighborhood Hits	912	Shared Neighborhood Hits	47
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.051984 (rank : 624)
Query Neighborhood Hits	376	Target Neighborhood Hits	906	Shared Neighborhood Hits	47
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.050741 (rank : 649)
Query Neighborhood Hits	376	Target Neighborhood Hits	1073	Shared Neighborhood Hits	47
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.050697 (rank : 650)
Query Neighborhood Hits	376	Target Neighborhood Hits	918	Shared Neighborhood Hits	44
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB4_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.051695 (rank : 628)
Query Neighborhood Hits	376	Target Neighborhood Hits	910	Shared Neighborhood Hits	46
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERC2_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.055648 (rank : 548)
Query Neighborhood Hits	376	Target Neighborhood Hits	1156	Shared Neighborhood Hits	118
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.058173 (rank : 495)
Query Neighborhood Hits	376	Target Neighborhood Hits	1166	Shared Neighborhood Hits	120
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ES8L1_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.149765 (rank : 243)
Query Neighborhood Hits	376	Target Neighborhood Hits	162	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.149098 (rank : 246)
Query Neighborhood Hits	376	Target Neighborhood Hits	143	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

EVPL_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.059997 (rank : 463)
Query Neighborhood Hits	376	Target Neighborhood Hits	895	Shared Neighborhood Hits	107
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

FAK1_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.050838 (rank : 646)
Query Neighborhood Hits	376	Target Neighborhood Hits	850	Shared Neighborhood Hits	43
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.050693 (rank : 651)
Query Neighborhood Hits	376	Target Neighborhood Hits	850	Shared Neighborhood Hits	42
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.053180 (rank : 586)
Query Neighborhood Hits	376	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.053158 (rank : 587)
Query Neighborhood Hits	376	Target Neighborhood Hits	851	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FER_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.077793 (rank : 346)
Query Neighborhood Hits	376	Target Neighborhood Hits	1278	Shared Neighborhood Hits	143
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.059520 (rank : 473)
Query Neighborhood Hits	376	Target Neighborhood Hits	978	Shared Neighborhood Hits	70
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.056858 (rank : 520)
Query Neighborhood Hits	376	Target Neighborhood Hits	980	Shared Neighborhood Hits	77
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.353132 (rank : 118)
Query Neighborhood Hits	376	Target Neighborhood Hits	367	Shared Neighborhood Hits	74
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.349883 (rank : 120)
Query Neighborhood Hits	376	Target Neighborhood Hits	387	Shared Neighborhood Hits	70
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.384922 (rank : 105)
Query Neighborhood Hits	376	Target Neighborhood Hits	249	Shared Neighborhood Hits	62
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD5_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.206414 (rank : 194)
Query Neighborhood Hits	376	Target Neighborhood Hits	235	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.186028 (rank : 207)
Query Neighborhood Hits	376	Target Neighborhood Hits	170	Shared Neighborhood Hits	43
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.294739 (rank : 139)
Query Neighborhood Hits	376	Target Neighborhood Hits	237	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FLT3_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.050292 (rank : 663)
Query Neighborhood Hits	376	Target Neighborhood Hits	843	Shared Neighborhood Hits	42
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.050427 (rank : 660)
Query Neighborhood Hits	376	Target Neighborhood Hits	847	Shared Neighborhood Hits	41
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FYCO1_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.052252 (rank : 616)
Query Neighborhood Hits	376	Target Neighborhood Hits	1149	Shared Neighborhood Hits	112
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.054668 (rank : 560)
Query Neighborhood Hits	376	Target Neighborhood Hits	1059	Shared Neighborhood Hits	112
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GAS8_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.055836 (rank : 541)
Query Neighborhood Hits	376	Target Neighborhood Hits	819	Shared Neighborhood Hits	98
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GCC2_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.058788 (rank : 484)
Query Neighborhood Hits	376	Target Neighborhood Hits	1558	Shared Neighborhood Hits	132
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GOGA1_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.056358 (rank : 530)
Query Neighborhood Hits	376	Target Neighborhood Hits	1222	Shared Neighborhood Hits	116
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA1_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.054090 (rank : 568)
Query Neighborhood Hits	376	Target Neighborhood Hits	994	Shared Neighborhood Hits	108
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA2_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.051940 (rank : 626)
Query Neighborhood Hits	376	Target Neighborhood Hits	944	Shared Neighborhood Hits	111
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

GOGA3_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.053927 (rank : 572)
Query Neighborhood Hits	376	Target Neighborhood Hits	1317	Shared Neighborhood Hits	120
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA3_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.062285 (rank : 442)
Query Neighborhood Hits	376	Target Neighborhood Hits	1437	Shared Neighborhood Hits	126
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GOGA4_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.059874 (rank : 466)
Query Neighborhood Hits	376	Target Neighborhood Hits	1939	Shared Neighborhood Hits	136
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

GOGA5_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.053941 (rank : 571)
Query Neighborhood Hits	376	Target Neighborhood Hits	1168	Shared Neighborhood Hits	110
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

GOGA5_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.056578 (rank : 525)
Query Neighborhood Hits	376	Target Neighborhood Hits	1434	Shared Neighborhood Hits	126
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

GOGA6_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.052873 (rank : 595)
Query Neighborhood Hits	376	Target Neighborhood Hits	1007	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

GRB10_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.076475 (rank : 353)
Query Neighborhood Hits	376	Target Neighborhood Hits	147	Shared Neighborhood Hits	46
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.076724 (rank : 352)
Query Neighborhood Hits	376	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.098287 (rank : 314)
Query Neighborhood Hits	376	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.099953 (rank : 311)
Query Neighborhood Hits	376	Target Neighborhood Hits	149	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.080139 (rank : 343)
Query Neighborhood Hits	376	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.090234 (rank : 324)
Query Neighborhood Hits	376	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRP3_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.064335 (rank : 427)
Query Neighborhood Hits	376	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HGS_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.055893 (rank : 540)
Query Neighborhood Hits	376	Target Neighborhood Hits	517	Shared Neighborhood Hits	42
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.056504 (rank : 527)
Query Neighborhood Hits	376	Target Neighborhood Hits	589	Shared Neighborhood Hits	48
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HMMR_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.061054 (rank : 453)
Query Neighborhood Hits	376	Target Neighborhood Hits	1178	Shared Neighborhood Hits	116
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

HOOK1_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.055777 (rank : 543)
Query Neighborhood Hits	376	Target Neighborhood Hits	910	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

HOOK3_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.063909 (rank : 432)
Query Neighborhood Hits	376	Target Neighborhood Hits	1070	Shared Neighborhood Hits	123
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

HOOK3_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.064109 (rank : 428)
Query Neighborhood Hits	376	Target Neighborhood Hits	1007	Shared Neighborhood Hits	119
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

HSH2D_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.092180 (rank : 322)
Query Neighborhood Hits	376	Target Neighborhood Hits	159	Shared Neighborhood Hits	36
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.064430 (rank : 426)
Query Neighborhood Hits	376	Target Neighborhood Hits	124	Shared Neighborhood Hits	27
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IF3A_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.051579 (rank : 631)
Query Neighborhood Hits	376	Target Neighborhood Hits	871	Shared Neighborhood Hits	103
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

IFT74_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.057489 (rank : 506)
Query Neighborhood Hits	376	Target Neighborhood Hits	949	Shared Neighborhood Hits	98
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT74_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.056591 (rank : 524)
Query Neighborhood Hits	376	Target Neighborhood Hits	939	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT81_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.052306 (rank : 615)
Query Neighborhood Hits	376	Target Neighborhood Hits	893	Shared Neighborhood Hits	101
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IFT81_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.057901 (rank : 501)
Query Neighborhood Hits	376	Target Neighborhood Hits	959	Shared Neighborhood Hits	104
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IGF1R_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.051003 (rank : 642)
Query Neighborhood Hits	376	Target Neighborhood Hits	977	Shared Neighborhood Hits	44
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.051145 (rank : 638)
Query Neighborhood Hits	376	Target Neighborhood Hits	973	Shared Neighborhood Hits	43
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ILK1_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.059129 (rank : 480)
Query Neighborhood Hits	376	Target Neighborhood Hits	857	Shared Neighborhood Hits	55
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.058240 (rank : 494)
Query Neighborhood Hits	376	Target Neighborhood Hits	848	Shared Neighborhood Hits	55
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.059296 (rank : 475)
Query Neighborhood Hits	376	Target Neighborhood Hits	858	Shared Neighborhood Hits	55
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INCE_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.054223 (rank : 567)
Query Neighborhood Hits	376	Target Neighborhood Hits	978	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

INCE_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.055685 (rank : 547)
Query Neighborhood Hits	376	Target Neighborhood Hits	903	Shared Neighborhood Hits	110
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

INVO_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.052714 (rank : 602)
Query Neighborhood Hits	376	Target Neighborhood Hits	636	Shared Neighborhood Hits	84
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

ITK_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.103244 (rank : 305)
Query Neighborhood Hits	376	Target Neighborhood Hits	1016	Shared Neighborhood Hits	136
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.096667 (rank : 317)
Query Neighborhood Hits	376	Target Neighborhood Hits	985	Shared Neighborhood Hits	120
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JIP1_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.074287 (rank : 360)
Query Neighborhood Hits	376	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

K0555_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.057023 (rank : 516)
Query Neighborhood Hits	376	Target Neighborhood Hits	880	Shared Neighborhood Hits	107
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

KMHN1_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.054860 (rank : 556)
Query Neighborhood Hits	376	Target Neighborhood Hits	949	Shared Neighborhood Hits	106
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

KSYK_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.070554 (rank : 378)
Query Neighborhood Hits	376	Target Neighborhood Hits	901	Shared Neighborhood Hits	63
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.071812 (rank : 374)
Query Neighborhood Hits	376	Target Neighborhood Hits	944	Shared Neighborhood Hits	65
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KTN1_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.050578 (rank : 657)
Query Neighborhood Hits	376	Target Neighborhood Hits	1197	Shared Neighborhood Hits	111
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

KTN1_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.055211 (rank : 553)
Query Neighborhood Hits	376	Target Neighborhood Hits	1324	Shared Neighborhood Hits	120
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LBC_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.274843 (rank : 149)
Query Neighborhood Hits	376	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.112241 (rank : 290)
Query Neighborhood Hits	376	Target Neighborhood Hits	987	Shared Neighborhood Hits	122
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.111590 (rank : 292)
Query Neighborhood Hits	376	Target Neighborhood Hits	981	Shared Neighborhood Hits	122
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.066508 (rank : 401)
Query Neighborhood Hits	376	Target Neighborhood Hits	531	Shared Neighborhood Hits	50
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.072561 (rank : 369)
Query Neighborhood Hits	376	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.098861 (rank : 312)
Query Neighborhood Hits	376	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.096530 (rank : 318)
Query Neighborhood Hits	376	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LTK_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.053730 (rank : 575)
Query Neighborhood Hits	376	Target Neighborhood Hits	774	Shared Neighborhood Hits	42
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.053153 (rank : 589)
Query Neighborhood Hits	376	Target Neighborhood Hits	770	Shared Neighborhood Hits	43
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

MACF1_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.055800 (rank : 542)
Query Neighborhood Hits	376	Target Neighborhood Hits	1341	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.062534 (rank : 441)
Query Neighborhood Hits	376	Target Neighborhood Hits	1321	Shared Neighborhood Hits	121
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MATK_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.083332 (rank : 334)
Query Neighborhood Hits	376	Target Neighborhood Hits	954	Shared Neighborhood Hits	83
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.084721 (rank : 331)
Query Neighborhood Hits	376	Target Neighborhood Hits	952	Shared Neighborhood Hits	88
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MD1L1_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.053602 (rank : 579)
Query Neighborhood Hits	376	Target Neighborhood Hits	1001	Shared Neighborhood Hits	102
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MIA_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.057662 (rank : 505)
Query Neighborhood Hits	376	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.055088 (rank : 554)
Query Neighborhood Hits	376	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MOES_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.054027 (rank : 569)
Query Neighborhood Hits	376	Target Neighborhood Hits	923	Shared Neighborhood Hits	106
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MPP3_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.050035 (rank : 667)
Query Neighborhood Hits	376	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP4_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.060604 (rank : 459)
Query Neighborhood Hits	376	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.066507 (rank : 402)
Query Neighborhood Hits	376	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP5_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.082552 (rank : 337)
Query Neighborhood Hits	376	Target Neighborhood Hits	231	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.082016 (rank : 339)
Query Neighborhood Hits	376	Target Neighborhood Hits	226	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MRCKA_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.052733 (rank : 601)
Query Neighborhood Hits	376	Target Neighborhood Hits	1999	Shared Neighborhood Hits	155
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MRCKB_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.056192 (rank : 536)
Query Neighborhood Hits	376	Target Neighborhood Hits	2239	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MY18A_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.070014 (rank : 381)
Query Neighborhood Hits	376	Target Neighborhood Hits	1929	Shared Neighborhood Hits	147
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.066169 (rank : 405)
Query Neighborhood Hits	376	Target Neighborhood Hits	1989	Shared Neighborhood Hits	147
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18B_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.058379 (rank : 491)
Query Neighborhood Hits	376	Target Neighborhood Hits	1299	Shared Neighborhood Hits	118
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYH14_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.057663 (rank : 504)
Query Neighborhood Hits	376	Target Neighborhood Hits	995	Shared Neighborhood Hits	109
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH14_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.058542 (rank : 490)
Query Neighborhood Hits	376	Target Neighborhood Hits	1225	Shared Neighborhood Hits	118
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH4_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.059188 (rank : 479)
Query Neighborhood Hits	376	Target Neighborhood Hits	1377	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYO10_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.056514 (rank : 526)
Query Neighborhood Hits	376	Target Neighborhood Hits	920	Shared Neighborhood Hits	107
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYO5A_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.053313 (rank : 583)
Query Neighborhood Hits	376	Target Neighborhood Hits	1092	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MYO5A_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.051124 (rank : 639)
Query Neighborhood Hits	376	Target Neighborhood Hits	1117	Shared Neighborhood Hits	109
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5B_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.050580 (rank : 655)
Query Neighborhood Hits	376	Target Neighborhood Hits	911	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

MYO5C_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.059245 (rank : 476)
Query Neighborhood Hits	376	Target Neighborhood Hits	1206	Shared Neighborhood Hits	118
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYO6_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.052891 (rank : 594)
Query Neighborhood Hits	376	Target Neighborhood Hits	727	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO6_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.051592 (rank : 630)
Query Neighborhood Hits	376	Target Neighborhood Hits	586	Shared Neighborhood Hits	81
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

NGEF_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.386667 (rank : 103)
Query Neighborhood Hits	376	Target Neighborhood Hits	166	Shared Neighborhood Hits	120
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NIN_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.053099 (rank : 591)
Query Neighborhood Hits	376	Target Neighborhood Hits	1416	Shared Neighborhood Hits	121
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.343276 (rank : 121)
Query Neighborhood Hits	376	Target Neighborhood Hits	267	Shared Neighborhood Hits	187
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OPTN_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.052944 (rank : 593)
Query Neighborhood Hits	376	Target Neighborhood Hits	827	Shared Neighborhood Hits	99
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

OPTN_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.053683 (rank : 578)
Query Neighborhood Hits	376	Target Neighborhood Hits	1120	Shared Neighborhood Hits	108
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

P55G_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.122623 (rank : 276)
Query Neighborhood Hits	376	Target Neighborhood Hits	451	Shared Neighborhood Hits	110
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.119312 (rank : 281)
Query Neighborhood Hits	376	Target Neighborhood Hits	401	Shared Neighborhood Hits	107
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.153534 (rank : 239)
Query Neighborhood Hits	376	Target Neighborhood Hits	479	Shared Neighborhood Hits	145
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.156045 (rank : 237)
Query Neighborhood Hits	376	Target Neighborhood Hits	435	Shared Neighborhood Hits	133
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.143903 (rank : 251)
Query Neighborhood Hits	376	Target Neighborhood Hits	543	Shared Neighborhood Hits	139
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.140033 (rank : 255)
Query Neighborhood Hits	376	Target Neighborhood Hits	519	Shared Neighborhood Hits	137
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCNT_MOUSE
θ value	θ > 10 (rank : 589)	NC score	0.053336 (rank : 582)
Query Neighborhood Hits	376	Target Neighborhood Hits	1207	Shared Neighborhood Hits	114
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PIBF1_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.060456 (rank : 460)
Query Neighborhood Hits	376	Target Neighborhood Hits	1041	Shared Neighborhood Hits	111
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

PKHF1_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.080682 (rank : 342)
Query Neighborhood Hits	376	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.076356 (rank : 354)
Query Neighborhood Hits	376	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.083271 (rank : 336)
Query Neighborhood Hits	376	Target Neighborhood Hits	75	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.083319 (rank : 335)
Query Neighborhood Hits	376	Target Neighborhood Hits	77	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCB1_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.054905 (rank : 555)
Query Neighborhood Hits	376	Target Neighborhood Hits	614	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB1_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.052368 (rank : 614)
Query Neighborhood Hits	376	Target Neighborhood Hits	531	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB2_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.057070 (rank : 514)
Query Neighborhood Hits	376	Target Neighborhood Hits	608	Shared Neighborhood Hits	88
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLCB3_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.052592 (rank : 606)
Query Neighborhood Hits	376	Target Neighborhood Hits	445	Shared Neighborhood Hits	70
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCB4_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.063635 (rank : 435)
Query Neighborhood Hits	376	Target Neighborhood Hits	658	Shared Neighborhood Hits	86
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PPIP2_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.074417 (rank : 359)
Query Neighborhood Hits	376	Target Neighborhood Hits	254	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.068272 (rank : 387)
Query Neighborhood Hits	376	Target Neighborhood Hits	308	Shared Neighborhood Hits	64
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PTN11_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.077355 (rank : 350)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.077366 (rank : 349)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.065868 (rank : 408)
Query Neighborhood Hits	376	Target Neighborhood Hits	234	Shared Neighborhood Hits	51
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 605)	NC score	0.066404 (rank : 403)
Query Neighborhood Hits	376	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RABE1_HUMAN
θ value	θ > 10 (rank : 606)	NC score	0.052027 (rank : 621)
Query Neighborhood Hits	376	Target Neighborhood Hits	1104	Shared Neighborhood Hits	112
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RAD50_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.059371 (rank : 474)
Query Neighborhood Hits	376	Target Neighborhood Hits	1317	Shared Neighborhood Hits	118
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAD50_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.061458 (rank : 450)
Query Neighborhood Hits	376	Target Neighborhood Hits	1366	Shared Neighborhood Hits	121
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RADI_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.052449 (rank : 611)
Query Neighborhood Hits	376	Target Neighborhood Hits	741	Shared Neighborhood Hits	102
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.050123 (rank : 665)
Query Neighborhood Hits	376	Target Neighborhood Hits	773	Shared Neighborhood Hits	96
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

RASA1_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.134782 (rank : 260)
Query Neighborhood Hits	376	Target Neighborhood Hits	258	Shared Neighborhood Hits	69
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RB6I2_HUMAN
θ value	θ > 10 (rank : 612)	NC score	0.052754 (rank : 599)
Query Neighborhood Hits	376	Target Neighborhood Hits	1584	Shared Neighborhood Hits	120
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
θ value	θ > 10 (rank : 613)	NC score	0.053215 (rank : 585)
Query Neighborhood Hits	376	Target Neighborhood Hits	1433	Shared Neighborhood Hits	116
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RBCC1_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.050194 (rank : 664)
Query Neighborhood Hits	376	Target Neighborhood Hits	1048	Shared Neighborhood Hits	105
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RBP24_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.058719 (rank : 485)
Query Neighborhood Hits	376	Target Neighborhood Hits	1559	Shared Neighborhood Hits	131
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

REN3B_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.060806 (rank : 456)
Query Neighborhood Hits	376	Target Neighborhood Hits	412	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

REPS1_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.057686 (rank : 503)
Query Neighborhood Hits	376	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.058088 (rank : 498)
Query Neighborhood Hits	376	Target Neighborhood Hits	204	Shared Neighborhood Hits	18
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.066982 (rank : 396)
Query Neighborhood Hits	376	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.066535 (rank : 400)
Query Neighborhood Hits	376	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REST_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.056249 (rank : 534)
Query Neighborhood Hits	376	Target Neighborhood Hits	1605	Shared Neighborhood Hits	127
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

REST_MOUSE
θ value	θ > 10 (rank : 622)	NC score	0.055318 (rank : 552)
Query Neighborhood Hits	376	Target Neighborhood Hits	1506	Shared Neighborhood Hits	122
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RHG09_HUMAN
θ value	θ > 10 (rank : 623)	NC score	0.055915 (rank : 539)
Query Neighborhood Hits	376	Target Neighborhood Hits	186	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.056253 (rank : 533)
Query Neighborhood Hits	376	Target Neighborhood Hits	190	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.058316 (rank : 493)
Query Neighborhood Hits	376	Target Neighborhood Hits	204	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

ROCK1_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.051509 (rank : 633)
Query Neighborhood Hits	376	Target Neighborhood Hits	2000	Shared Neighborhood Hits	152
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.053219 (rank : 584)
Query Neighborhood Hits	376	Target Neighborhood Hits	2126	Shared Neighborhood Hits	154
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RON_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.050420 (rank : 661)
Query Neighborhood Hits	376	Target Neighborhood Hits	842	Shared Neighborhood Hits	43
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.050608 (rank : 654)
Query Neighborhood Hits	376	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR2_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.050644 (rank : 652)
Query Neighborhood Hits	376	Target Neighborhood Hits	1014	Shared Neighborhood Hits	42
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.051038 (rank : 641)
Query Neighborhood Hits	376	Target Neighborhood Hits	1000	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.053137 (rank : 590)
Query Neighborhood Hits	376	Target Neighborhood Hits	907	Shared Neighborhood Hits	45
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RUFY1_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.056877 (rank : 519)
Query Neighborhood Hits	376	Target Neighborhood Hits	848	Shared Neighborhood Hits	108
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.053156 (rank : 588)
Query Neighborhood Hits	376	Target Neighborhood Hits	765	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.064632 (rank : 424)
Query Neighborhood Hits	376	Target Neighborhood Hits	1208	Shared Neighborhood Hits	116
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.054806 (rank : 557)
Query Neighborhood Hits	376	Target Neighborhood Hits	820	Shared Neighborhood Hits	103
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUSC1_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.190494 (rank : 204)
Query Neighborhood Hits	376	Target Neighborhood Hits	226	Shared Neighborhood Hits	129
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 638)	NC score	0.172826 (rank : 218)
Query Neighborhood Hits	376	Target Neighborhood Hits	206	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_HUMAN
θ value	θ > 10 (rank : 639)	NC score	0.073427 (rank : 363)
Query Neighborhood Hits	376	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 640)	NC score	0.070200 (rank : 380)
Query Neighborhood Hits	376	Target Neighborhood Hits	305	Shared Neighborhood Hits	62
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RYK_HUMAN
θ value	θ > 10 (rank : 641)	NC score	0.052676 (rank : 604)
Query Neighborhood Hits	376	Target Neighborhood Hits	701	Shared Neighborhood Hits	36
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 642)	NC score	0.052063 (rank : 620)
Query Neighborhood Hits	376	Target Neighborhood Hits	715	Shared Neighborhood Hits	36
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SDCG8_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.055415 (rank : 551)
Query Neighborhood Hits	376	Target Neighborhood Hits	1002	Shared Neighborhood Hits	102
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

SH21A_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.084888 (rank : 330)
Query Neighborhood Hits	376	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.084626 (rank : 332)
Query Neighborhood Hits	376	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.101410 (rank : 309)
Query Neighborhood Hits	376	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.110183 (rank : 295)
Query Neighborhood Hits	376	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.065508 (rank : 414)
Query Neighborhood Hits	376	Target Neighborhood Hits	144	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.075822 (rank : 355)
Query Neighborhood Hits	376	Target Neighborhood Hits	179	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.060761 (rank : 457)
Query Neighborhood Hits	376	Target Neighborhood Hits	149	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.095101 (rank : 319)
Query Neighborhood Hits	376	Target Neighborhood Hits	455	Shared Neighborhood Hits	94
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.067341 (rank : 394)
Query Neighborhood Hits	376	Target Neighborhood Hits	326	Shared Neighborhood Hits	62
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 653)	NC score	0.067924 (rank : 391)
Query Neighborhood Hits	376	Target Neighborhood Hits	188	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 654)	NC score	0.072964 (rank : 366)
Query Neighborhood Hits	376	Target Neighborhood Hits	174	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.104491 (rank : 303)
Query Neighborhood Hits	376	Target Neighborhood Hits	141	Shared Neighborhood Hits	45
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.107228 (rank : 298)
Query Neighborhood Hits	376	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.102294 (rank : 306)
Query Neighborhood Hits	376	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 658)	NC score	0.101817 (rank : 307)
Query Neighborhood Hits	376	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.100657 (rank : 310)
Query Neighborhood Hits	376	Target Neighborhood Hits	170	Shared Neighborhood Hits	49
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 660)	NC score	0.098576 (rank : 313)
Query Neighborhood Hits	376	Target Neighborhood Hits	144	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.096802 (rank : 316)
Query Neighborhood Hits	376	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 662)	NC score	0.104497 (rank : 302)
Query Neighborhood Hits	376	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.101609 (rank : 308)
Query Neighborhood Hits	376	Target Neighborhood Hits	204	Shared Neighborhood Hits	44
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 664)	NC score	0.103430 (rank : 304)
Query Neighborhood Hits	376	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.109617 (rank : 296)
Query Neighborhood Hits	376	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 666)	NC score	0.113066 (rank : 289)
Query Neighborhood Hits	376	Target Neighborhood Hits	169	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.170159 (rank : 222)
Query Neighborhood Hits	376	Target Neighborhood Hits	96	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 668)	NC score	0.171851 (rank : 220)
Query Neighborhood Hits	376	Target Neighborhood Hits	101	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.149170 (rank : 244)
Query Neighborhood Hits	376	Target Neighborhood Hits	86	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 670)	NC score	0.150060 (rank : 242)
Query Neighborhood Hits	376	Target Neighborhood Hits	88	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.158999 (rank : 235)
Query Neighborhood Hits	376	Target Neighborhood Hits	113	Shared Neighborhood Hits	45
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.157811 (rank : 236)
Query Neighborhood Hits	376	Target Neighborhood Hits	117	Shared Neighborhood Hits	46
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.173310 (rank : 216)
Query Neighborhood Hits	376	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 674)	NC score	0.172117 (rank : 219)
Query Neighborhood Hits	376	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SM1L2_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.061560 (rank : 448)
Query Neighborhood Hits	376	Target Neighborhood Hits	1019	Shared Neighborhood Hits	107
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SM1L2_MOUSE
θ value	θ > 10 (rank : 676)	NC score	0.060446 (rank : 461)
Query Neighborhood Hits	376	Target Neighborhood Hits	918	Shared Neighborhood Hits	109
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SMC2_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.058132 (rank : 497)
Query Neighborhood Hits	376	Target Neighborhood Hits	1405	Shared Neighborhood Hits	124
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SOCS2_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.051728 (rank : 627)
Query Neighborhood Hits	376	Target Neighborhood Hits	104	Shared Neighborhood Hits	32
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.055416 (rank : 550)
Query Neighborhood Hits	376	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.063200 (rank : 439)
Query Neighborhood Hits	376	Target Neighborhood Hits	126	Shared Neighborhood Hits	34
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 681)	NC score	0.063655 (rank : 434)
Query Neighborhood Hits	376	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.065717 (rank : 411)
Query Neighborhood Hits	376	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPN90_MOUSE
θ value	θ > 10 (rank : 683)	NC score	0.135321 (rank : 259)
Query Neighborhood Hits	376	Target Neighborhood Hits	157	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTB2_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.063423 (rank : 436)
Query Neighborhood Hits	376	Target Neighborhood Hits	748	Shared Neighborhood Hits	111
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.063320 (rank : 437)
Query Neighborhood Hits	376	Target Neighborhood Hits	770	Shared Neighborhood Hits	114
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTN5_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.050579 (rank : 656)
Query Neighborhood Hits	376	Target Neighborhood Hits	674	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

SRMS_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.086523 (rank : 328)
Query Neighborhood Hits	376	Target Neighborhood Hits	946	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.092861 (rank : 320)
Query Neighborhood Hits	376	Target Neighborhood Hits	964	Shared Neighborhood Hits	109
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STYK1_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.056887 (rank : 518)
Query Neighborhood Hits	376	Target Neighborhood Hits	786	Shared Neighborhood Hits	42
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 690)	NC score	0.056998 (rank : 517)
Query Neighborhood Hits	376	Target Neighborhood Hits	779	Shared Neighborhood Hits	42
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SWP70_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.061050 (rank : 454)
Query Neighborhood Hits	376	Target Neighborhood Hits	973	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 692)	NC score	0.059736 (rank : 468)
Query Neighborhood Hits	376	Target Neighborhood Hits	1097	Shared Neighborhood Hits	117
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYCP1_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.056240 (rank : 535)
Query Neighborhood Hits	376	Target Neighborhood Hits	1313	Shared Neighborhood Hits	117
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYNE1_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.064085 (rank : 429)
Query Neighborhood Hits	376	Target Neighborhood Hits	1484	Shared Neighborhood Hits	131
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TAXB1_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.057191 (rank : 510)
Query Neighborhood Hits	376	Target Neighborhood Hits	829	Shared Neighborhood Hits	98
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TAXB1_MOUSE
θ value	θ > 10 (rank : 696)	NC score	0.055771 (rank : 544)
Query Neighborhood Hits	376	Target Neighborhood Hits	886	Shared Neighborhood Hits	106
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

TEX14_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.065099 (rank : 420)
Query Neighborhood Hits	376	Target Neighborhood Hits	1103	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TMF1_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.051291 (rank : 635)
Query Neighborhood Hits	376	Target Neighborhood Hits	987	Shared Neighborhood Hits	104
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

TNK1_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.054571 (rank : 561)
Query Neighborhood Hits	376	Target Neighborhood Hits	815	Shared Neighborhood Hits	48
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.056382 (rank : 528)
Query Neighborhood Hits	376	Target Neighborhood Hits	806	Shared Neighborhood Hits	48
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TPR_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.054715 (rank : 559)
Query Neighborhood Hits	376	Target Neighborhood Hits	1921	Shared Neighborhood Hits	134
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TRHY_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.054732 (rank : 558)
Query Neighborhood Hits	376	Target Neighborhood Hits	1385	Shared Neighborhood Hits	122
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

TUFT1_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.052820 (rank : 597)
Query Neighborhood Hits	376	Target Neighborhood Hits	686	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

TXK_HUMAN
θ value	θ > 10 (rank : 704)	NC score	0.106636 (rank : 300)
Query Neighborhood Hits	376	Target Neighborhood Hits	971	Shared Neighborhood Hits	128
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 705)	NC score	0.112166 (rank : 291)
Query Neighborhood Hits	376	Target Neighborhood Hits	980	Shared Neighborhood Hits	144
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

XE7_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.052011 (rank : 622)
Query Neighborhood Hits	376	Target Neighborhood Hits	738	Shared Neighborhood Hits	95
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

ZAP70_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.072175 (rank : 373)
Query Neighborhood Hits	376	Target Neighborhood Hits	893	Shared Neighborhood Hits	64
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 708)	NC score	0.072361 (rank : 370)
Query Neighborhood Hits	376	Target Neighborhood Hits	905	Shared Neighborhood Hits	63
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

ARHG6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	376	Target Neighborhood Hits	376	Shared Neighborhood Hits	376
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
NC score	0.986476 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	376	Target Neighborhood Hits	394	Shared Neighborhood Hits	327
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
NC score	0.954858 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	376	Target Neighborhood Hits	347	Shared Neighborhood Hits	265
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.941658 (rank : 4)	θ value	3.96267e-181 (rank : 4)
Query Neighborhood Hits	376	Target Neighborhood Hits	396	Shared Neighborhood Hits	270
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG4_HUMAN
NC score	0.741355 (rank : 5)	θ value	1.99067e-23 (rank : 6)
Query Neighborhood Hits	376	Target Neighborhood Hits	242	Shared Neighborhood Hits	197
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
NC score	0.719311 (rank : 6)	θ value	9.56915e-18 (rank : 13)
Query Neighborhood Hits	376	Target Neighborhood Hits	235	Shared Neighborhood Hits	189
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.718644 (rank : 7)	θ value	1.24977e-17 (rank : 14)
Query Neighborhood Hits	376	Target Neighborhood Hits	234	Shared Neighborhood Hits	189
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG4_MOUSE
NC score	0.710356 (rank : 8)	θ value	1.42661e-21 (rank : 7)
Query Neighborhood Hits	376	Target Neighborhood Hits	185	Shared Neighborhood Hits	153
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

DNMBP_MOUSE
NC score	0.687934 (rank : 9)	θ value	1.74796e-11 (rank : 26)
Query Neighborhood Hits	376	Target Neighborhood Hits	435	Shared Neighborhood Hits	233
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
NC score	0.685832 (rank : 10)	θ value	2.98157e-11 (rank : 27)
Query Neighborhood Hits	376	Target Neighborhood Hits	413	Shared Neighborhood Hits	241
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV_MOUSE
NC score	0.639878 (rank : 11)	θ value	3.08544e-08 (rank : 44)
Query Neighborhood Hits	376	Target Neighborhood Hits	430	Shared Neighborhood Hits	250
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.634449 (rank : 12)	θ value	2.98157e-11 (rank : 28)
Query Neighborhood Hits	376	Target Neighborhood Hits	452	Shared Neighborhood Hits	249
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PKHG1_HUMAN
NC score	0.631240 (rank : 13)	θ value	3.62785e-25 (rank : 5)
Query Neighborhood Hits	376	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

VAV2_HUMAN
NC score	0.624841 (rank : 14)	θ value	2.0648e-12 (rank : 22)
Query Neighborhood Hits	376	Target Neighborhood Hits	453	Shared Neighborhood Hits	242
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SH3K1_HUMAN
NC score	0.620464 (rank : 15)	θ value	7.84624e-12 (rank : 24)
Query Neighborhood Hits	376	Target Neighborhood Hits	341	Shared Neighborhood Hits	212
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

VAV2_MOUSE
NC score	0.620122 (rank : 16)	θ value	5.26297e-08 (rank : 49)
Query Neighborhood Hits	376	Target Neighborhood Hits	456	Shared Neighborhood Hits	242
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.618507 (rank : 17)	θ value	1.99529e-15 (rank : 17)
Query Neighborhood Hits	376	Target Neighborhood Hits	404	Shared Neighborhood Hits	240
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.616288 (rank : 18)	θ value	3.76295e-14 (rank : 18)
Query Neighborhood Hits	376	Target Neighborhood Hits	398	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SH3K1_MOUSE
NC score	0.611943 (rank : 19)	θ value	6.64225e-11 (rank : 30)
Query Neighborhood Hits	376	Target Neighborhood Hits	332	Shared Neighborhood Hits	213
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.607560 (rank : 20)	θ value	1.9326e-10 (rank : 32)
Query Neighborhood Hits	376	Target Neighborhood Hits	336	Shared Neighborhood Hits	203
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.606366 (rank : 21)	θ value	6.21693e-09 (rank : 40)
Query Neighborhood Hits	376	Target Neighborhood Hits	315	Shared Neighborhood Hits	208
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ITSN2_HUMAN
NC score	0.589423 (rank : 22)	θ value	1.2077e-20 (rank : 10)
Query Neighborhood Hits	376	Target Neighborhood Hits	1173	Shared Neighborhood Hits	314
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PREX1_HUMAN
NC score	0.580298 (rank : 23)	θ value	5.42112e-21 (rank : 9)
Query Neighborhood Hits	376	Target Neighborhood Hits	177	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ITSN2_MOUSE
NC score	0.560207 (rank : 24)	θ value	1.74391e-19 (rank : 12)
Query Neighborhood Hits	376	Target Neighborhood Hits	1371	Shared Neighborhood Hits	317
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

TIAM1_MOUSE
NC score	0.551723 (rank : 25)	θ value	3.18553e-13 (rank : 20)
Query Neighborhood Hits	376	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ITSN1_HUMAN
NC score	0.551372 (rank : 26)	θ value	3.17815e-21 (rank : 8)
Query Neighborhood Hits	376	Target Neighborhood Hits	1757	Shared Neighborhood Hits	329
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.550859 (rank : 27)	θ value	2.06002e-20 (rank : 11)
Query Neighborhood Hits	376	Target Neighborhood Hits	1669	Shared Neighborhood Hits	327
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TIAM1_HUMAN
NC score	0.546413 (rank : 28)	θ value	2.43908e-13 (rank : 19)
Query Neighborhood Hits	376	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VINEX_HUMAN
NC score	0.543063 (rank : 29)	θ value	7.59969e-07 (rank : 58)
Query Neighborhood Hits	376	Target Neighborhood Hits	270	Shared Neighborhood Hits	187
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.542990 (rank : 30)	θ value	3.41135e-07 (rank : 55)
Query Neighborhood Hits	376	Target Neighborhood Hits	286	Shared Neighborhood Hits	189
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

MCF2_HUMAN
NC score	0.534762 (rank : 31)	θ value	7.34386e-10 (rank : 36)
Query Neighborhood Hits	376	Target Neighborhood Hits	166	Shared Neighborhood Hits	77
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ABI2_MOUSE
NC score	0.530739 (rank : 32)	θ value	4.0297e-08 (rank : 46)
Query Neighborhood Hits	376	Target Neighborhood Hits	266	Shared Neighborhood Hits	178
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.526178 (rank : 33)	θ value	4.0297e-08 (rank : 45)
Query Neighborhood Hits	376	Target Neighborhood Hits	350	Shared Neighborhood Hits	178
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

MCF2L_MOUSE
NC score	0.525845 (rank : 34)	θ value	1.80886e-08 (rank : 42)
Query Neighborhood Hits	376	Target Neighborhood Hits	255	Shared Neighborhood Hits	107
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

SRBS1_MOUSE
NC score	0.525823 (rank : 35)	θ value	2.21117e-06 (rank : 66)
Query Neighborhood Hits	376	Target Neighborhood Hits	409	Shared Neighborhood Hits	192
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.524777 (rank : 36)	θ value	1.29631e-06 (rank : 61)
Query Neighborhood Hits	376	Target Neighborhood Hits	396	Shared Neighborhood Hits	203
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCK1_HUMAN
NC score	0.523674 (rank : 37)	θ value	4.76016e-09 (rank : 39)
Query Neighborhood Hits	376	Target Neighborhood Hits	312	Shared Neighborhood Hits	188
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCF2_HUMAN
NC score	0.514316 (rank : 38)	θ value	0.0148317 (rank : 164)
Query Neighborhood Hits	376	Target Neighborhood Hits	229	Shared Neighborhood Hits	166
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCK2_HUMAN
NC score	0.512858 (rank : 39)	θ value	6.87365e-08 (rank : 50)
Query Neighborhood Hits	376	Target Neighborhood Hits	310	Shared Neighborhood Hits	187
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCF1_HUMAN
NC score	0.510281 (rank : 40)	θ value	5.44631e-05 (rank : 91)
Query Neighborhood Hits	376	Target Neighborhood Hits	198	Shared Neighborhood Hits	159
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

GRB2_HUMAN
NC score	0.506003 (rank : 41)	θ value	8.40245e-06 (rank : 74)
Query Neighborhood Hits	376	Target Neighborhood Hits	310	Shared Neighborhood Hits	185
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.505849 (rank : 42)	θ value	8.40245e-06 (rank : 75)
Query Neighborhood Hits	376	Target Neighborhood Hits	312	Shared Neighborhood Hits	185
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ABI1_MOUSE
NC score	0.505026 (rank : 43)	θ value	2.21117e-06 (rank : 64)
Query Neighborhood Hits	376	Target Neighborhood Hits	246	Shared Neighborhood Hits	169
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G3_MOUSE
NC score	0.502637 (rank : 44)	θ value	1.69304e-06 (rank : 63)
Query Neighborhood Hits	376	Target Neighborhood Hits	236	Shared Neighborhood Hits	189
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRC8_HUMAN
NC score	0.499021 (rank : 45)	θ value	0.000158464 (rank : 101)
Query Neighborhood Hits	376	Target Neighborhood Hits	269	Shared Neighborhood Hits	188
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

GRAP_MOUSE
NC score	0.497075 (rank : 46)	θ value	3.77169e-06 (rank : 68)
Query Neighborhood Hits	376	Target Neighborhood Hits	309	Shared Neighborhood Hits	191
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCF1_MOUSE
NC score	0.496469 (rank : 47)	θ value	0.000121331 (rank : 97)
Query Neighborhood Hits	376	Target Neighborhood Hits	198	Shared Neighborhood Hits	168
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SRC8_MOUSE
NC score	0.494162 (rank : 48)	θ value	0.000158464 (rank : 102)
Query Neighborhood Hits	376	Target Neighborhood Hits	292	Shared Neighborhood Hits	185
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ABI1_HUMAN
NC score	0.493516 (rank : 49)	θ value	9.92553e-07 (rank : 59)
Query Neighborhood Hits	376	Target Neighborhood Hits	257	Shared Neighborhood Hits	167
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

GRAP2_MOUSE
NC score	0.490927 (rank : 50)	θ value	0.00020696 (rank : 104)
Query Neighborhood Hits	376	Target Neighborhood Hits	297	Shared Neighborhood Hits	183
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
NC score	0.488604 (rank : 51)	θ value	0.000121331 (rank : 96)
Query Neighborhood Hits	376	Target Neighborhood Hits	307	Shared Neighborhood Hits	189
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SH3G2_HUMAN
NC score	0.488212 (rank : 52)	θ value	1.29631e-06 (rank : 60)
Query Neighborhood Hits	376	Target Neighborhood Hits	324	Shared Neighborhood Hits	197
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

GRAP2_HUMAN
NC score	0.485758 (rank : 53)	θ value	0.000461057 (rank : 111)
Query Neighborhood Hits	376	Target Neighborhood Hits	304	Shared Neighborhood Hits	185
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

HCLS1_MOUSE
NC score	0.484666 (rank : 54)	θ value	0.000786445 (rank : 119)
Query Neighborhood Hits	376	Target Neighborhood Hits	329	Shared Neighborhood Hits	166
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ARHG3_HUMAN
NC score	0.484361 (rank : 55)	θ value	3.41135e-07 (rank : 53)
Query Neighborhood Hits	376	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.484354 (rank : 56)	θ value	4.45536e-07 (rank : 56)
Query Neighborhood Hits	376	Target Neighborhood Hits	85	Shared Neighborhood Hits	58
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

HCLS1_HUMAN
NC score	0.483962 (rank : 57)	θ value	0.000786445 (rank : 118)
Query Neighborhood Hits	376	Target Neighborhood Hits	358	Shared Neighborhood Hits	165
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SH3G3_HUMAN
NC score	0.483897 (rank : 58)	θ value	8.40245e-06 (rank : 76)
Query Neighborhood Hits	376	Target Neighborhood Hits	222	Shared Neighborhood Hits	178
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G2_MOUSE
NC score	0.482442 (rank : 59)	θ value	2.21117e-06 (rank : 65)
Query Neighborhood Hits	376	Target Neighborhood Hits	319	Shared Neighborhood Hits	202
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

HAPIP_HUMAN
NC score	0.479173 (rank : 60)	θ value	2.35696e-16 (rank : 16)
Query Neighborhood Hits	376	Target Neighborhood Hits	350	Shared Neighborhood Hits	111
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG8_MOUSE
NC score	0.477938 (rank : 61)	θ value	4.30538e-10 (rank : 33)
Query Neighborhood Hits	376	Target Neighborhood Hits	79	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

STAC_HUMAN
NC score	0.476151 (rank : 62)	θ value	0.00035302 (rank : 109)
Query Neighborhood Hits	376	Target Neighborhood Hits	276	Shared Neighborhood Hits	187
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SH3G1_HUMAN
NC score	0.475471 (rank : 63)	θ value	1.69304e-06 (rank : 62)
Query Neighborhood Hits	376	Target Neighborhood Hits	307	Shared Neighborhood Hits	196
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

NCF4_MOUSE
NC score	0.474597 (rank : 64)	θ value	0.00298849 (rank : 142)
Query Neighborhood Hits	376	Target Neighborhood Hits	177	Shared Neighborhood Hits	139
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SH3G1_MOUSE
NC score	0.472251 (rank : 65)	θ value	2.44474e-05 (rank : 85)
Query Neighborhood Hits	376	Target Neighborhood Hits	291	Shared Neighborhood Hits	188
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

STAC_MOUSE
NC score	0.466374 (rank : 66)	θ value	0.000602161 (rank : 117)
Query Neighborhood Hits	376	Target Neighborhood Hits	268	Shared Neighborhood Hits	182
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
NC score	0.461953 (rank : 67)	θ value	0.000461057 (rank : 113)
Query Neighborhood Hits	376	Target Neighborhood Hits	271	Shared Neighborhood Hits	187
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.459722 (rank : 68)	θ value	0.00134147 (rank : 127)
Query Neighborhood Hits	376	Target Neighborhood Hits	273	Shared Neighborhood Hits	183
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF4_HUMAN
NC score	0.458387 (rank : 69)	θ value	0.00665767 (rank : 154)
Query Neighborhood Hits	376	Target Neighborhood Hits	161	Shared Neighborhood Hits	126
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM2_MOUSE
NC score	0.456239 (rank : 70)	θ value	0.000270298 (rank : 108)
Query Neighborhood Hits	376	Target Neighborhood Hits	285	Shared Neighborhood Hits	183
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ABI3_HUMAN
NC score	0.449639 (rank : 71)	θ value	0.00134147 (rank : 125)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ECT2_MOUSE
NC score	0.448605 (rank : 72)	θ value	1.87187e-05 (rank : 80)
Query Neighborhood Hits	376	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_MOUSE
NC score	0.448572 (rank : 73)	θ value	2.88788e-06 (rank : 67)
Query Neighborhood Hits	376	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PPIP1_HUMAN
NC score	0.446002 (rank : 74)	θ value	0.000461057 (rank : 112)
Query Neighborhood Hits	376	Target Neighborhood Hits	389	Shared Neighborhood Hits	224
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

STAM2_HUMAN
NC score	0.445867 (rank : 75)	θ value	0.00228821 (rank : 139)
Query Neighborhood Hits	376	Target Neighborhood Hits	288	Shared Neighborhood Hits	181
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

PPIP1_MOUSE
NC score	0.445375 (rank : 76)	θ value	0.00020696 (rank : 105)
Query Neighborhood Hits	376	Target Neighborhood Hits	377	Shared Neighborhood Hits	221
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ARHGA_HUMAN
NC score	0.445309 (rank : 77)	θ value	1.99992e-07 (rank : 51)
Query Neighborhood Hits	376	Target Neighborhood Hits	187	Shared Neighborhood Hits	71
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PKHG4_HUMAN
NC score	0.445263 (rank : 78)	θ value	1.87187e-05 (rank : 81)
Query Neighborhood Hits	376	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ABI3_MOUSE
NC score	0.443384 (rank : 79)	θ value	0.00509761 (rank : 147)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	147
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ECT2_HUMAN
NC score	0.439069 (rank : 80)	θ value	2.44474e-05 (rank : 84)
Query Neighborhood Hits	376	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG8_HUMAN
NC score	0.435481 (rank : 81)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	376	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

STAC3_MOUSE
NC score	0.434371 (rank : 82)	θ value	0.00175202 (rank : 134)
Query Neighborhood Hits	376	Target Neighborhood Hits	232	Shared Neighborhood Hits	153
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CRKL_HUMAN
NC score	0.433715 (rank : 83)	θ value	0.00390308 (rank : 144)
Query Neighborhood Hits	376	Target Neighborhood Hits	313	Shared Neighborhood Hits	183
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

OSTF1_HUMAN
NC score	0.432010 (rank : 84)	θ value	1.25267e-09 (rank : 38)
Query Neighborhood Hits	376	Target Neighborhood Hits	466	Shared Neighborhood Hits	191
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

STAC3_HUMAN
NC score	0.431596 (rank : 85)	θ value	0.00175202 (rank : 133)
Query Neighborhood Hits	376	Target Neighborhood Hits	228	Shared Neighborhood Hits	152
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG5_HUMAN
NC score	0.429352 (rank : 86)	θ value	0.00175202 (rank : 128)
Query Neighborhood Hits	376	Target Neighborhood Hits	172	Shared Neighborhood Hits	131
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FGD4_MOUSE
NC score	0.429183 (rank : 87)	θ value	5.43371e-13 (rank : 21)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
NC score	0.428815 (rank : 88)	θ value	4.59992e-12 (rank : 23)
Query Neighborhood Hits	376	Target Neighborhood Hits	219	Shared Neighborhood Hits	78
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

CRKL_MOUSE
NC score	0.427654 (rank : 89)	θ value	0.00390308 (rank : 145)
Query Neighborhood Hits	376	Target Neighborhood Hits	307	Shared Neighborhood Hits	179
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

OSTF1_MOUSE
NC score	0.423178 (rank : 90)	θ value	9.59137e-10 (rank : 37)
Query Neighborhood Hits	376	Target Neighborhood Hits	467	Shared Neighborhood Hits	192
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

CRK_MOUSE
NC score	0.422678 (rank : 91)	θ value	0.0193708 (rank : 169)
Query Neighborhood Hits	376	Target Neighborhood Hits	314	Shared Neighborhood Hits	184
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.416769 (rank : 92)	θ value	0.0431538 (rank : 182)
Query Neighborhood Hits	376	Target Neighborhood Hits	308	Shared Neighborhood Hits	184
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FGD3_MOUSE
NC score	0.416003 (rank : 93)	θ value	4.30538e-10 (rank : 34)
Query Neighborhood Hits	376	Target Neighborhood Hits	257	Shared Neighborhood Hits	67
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
NC score	0.414543 (rank : 94)	θ value	1.38499e-08 (rank : 41)
Query Neighborhood Hits	376	Target Neighborhood Hits	151	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

PACN2_HUMAN
NC score	0.407349 (rank : 95)	θ value	0.0148317 (rank : 165)
Query Neighborhood Hits	376	Target Neighborhood Hits	339	Shared Neighborhood Hits	214
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.405306 (rank : 96)	θ value	0.0113563 (rank : 161)
Query Neighborhood Hits	376	Target Neighborhood Hits	382	Shared Neighborhood Hits	215
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ARHGG_MOUSE
NC score	0.403369 (rank : 97)	θ value	0.00175202 (rank : 129)
Query Neighborhood Hits	376	Target Neighborhood Hits	152	Shared Neighborhood Hits	98
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD2_MOUSE
NC score	0.394713 (rank : 98)	θ value	1.43324e-05 (rank : 79)
Query Neighborhood Hits	376	Target Neighborhood Hits	163	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

DBNL_HUMAN
NC score	0.391915 (rank : 99)	θ value	0.0961366 (rank : 198)
Query Neighborhood Hits	376	Target Neighborhood Hits	244	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PLCG1_MOUSE
NC score	0.390353 (rank : 100)	θ value	4.0297e-08 (rank : 47)
Query Neighborhood Hits	376	Target Neighborhood Hits	314	Shared Neighborhood Hits	156
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NGEF_MOUSE
NC score	0.388556 (rank : 101)	θ value	6.88961 (rank : 351)
Query Neighborhood Hits	376	Target Neighborhood Hits	228	Shared Neighborhood Hits	124
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

DBNL_MOUSE
NC score	0.387616 (rank : 102)	θ value	0.0961366 (rank : 199)
Query Neighborhood Hits	376	Target Neighborhood Hits	306	Shared Neighborhood Hits	154
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NGEF_HUMAN
NC score	0.386667 (rank : 103)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	376	Target Neighborhood Hits	166	Shared Neighborhood Hits	120
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PACN1_HUMAN
NC score	0.385514 (rank : 104)	θ value	0.0330416 (rank : 180)
Query Neighborhood Hits	376	Target Neighborhood Hits	320	Shared Neighborhood Hits	194
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

FGD3_HUMAN
NC score	0.384922 (rank : 105)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	376	Target Neighborhood Hits	249	Shared Neighborhood Hits	62
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

PLCG2_HUMAN
NC score	0.383721 (rank : 106)	θ value	5.26297e-08 (rank : 48)
Query Neighborhood Hits	376	Target Neighborhood Hits	280	Shared Neighborhood Hits	149
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ARHGG_HUMAN
NC score	0.383356 (rank : 107)	θ value	0.0736092 (rank : 192)
Query Neighborhood Hits	376	Target Neighborhood Hits	129	Shared Neighborhood Hits	86
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

PLCG1_HUMAN
NC score	0.382952 (rank : 108)	θ value	1.80886e-08 (rank : 43)
Query Neighborhood Hits	376	Target Neighborhood Hits	293	Shared Neighborhood Hits	152
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PACN1_MOUSE
NC score	0.381902 (rank : 109)	θ value	0.0252991 (rank : 174)
Query Neighborhood Hits	376	Target Neighborhood Hits	283	Shared Neighborhood Hits	185
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

LASP1_HUMAN
NC score	0.379935 (rank : 110)	θ value	0.00869519 (rank : 158)
Query Neighborhood Hits	376	Target Neighborhood Hits	293	Shared Neighborhood Hits	154
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.378342 (rank : 111)	θ value	0.00665767 (rank : 153)
Query Neighborhood Hits	376	Target Neighborhood Hits	297	Shared Neighborhood Hits	154
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PACN3_MOUSE
NC score	0.372294 (rank : 112)	θ value	0.0193708 (rank : 171)
Query Neighborhood Hits	376	Target Neighborhood Hits	380	Shared Neighborhood Hits	203
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.371521 (rank : 113)	θ value	0.0330416 (rank : 181)
Query Neighborhood Hits	376	Target Neighborhood Hits	385	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NEBL_HUMAN
NC score	0.368200 (rank : 114)	θ value	0.00509761 (rank : 148)
Query Neighborhood Hits	376	Target Neighborhood Hits	457	Shared Neighborhood Hits	212
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

AHI1_HUMAN
NC score	0.364838 (rank : 115)	θ value	1.09739e-05 (rank : 77)
Query Neighborhood Hits	376	Target Neighborhood Hits	537	Shared Neighborhood Hits	187
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CT032_HUMAN
NC score	0.360201 (rank : 116)	θ value	0.00228821 (rank : 137)
Query Neighborhood Hits	376	Target Neighborhood Hits	235	Shared Neighborhood Hits	133
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

AHI1_MOUSE
NC score	0.358761 (rank : 117)	θ value	0.000158464 (rank : 98)
Query Neighborhood Hits	376	Target Neighborhood Hits	496	Shared Neighborhood Hits	186
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

FGD1_HUMAN
NC score	0.353132 (rank : 118)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	376	Target Neighborhood Hits	367	Shared Neighborhood Hits	74
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FARP2_MOUSE
NC score	0.351602 (rank : 119)	θ value	1.33837e-11 (rank : 25)
Query Neighborhood Hits	376	Target Neighborhood Hits	209	Shared Neighborhood Hits	67
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD1_MOUSE
NC score	0.349883 (rank : 120)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	376	Target Neighborhood Hits	387	Shared Neighborhood Hits	70
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

NPHP1_MOUSE
NC score	0.343276 (rank : 121)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	376	Target Neighborhood Hits	267	Shared Neighborhood Hits	187
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

GNRP_MOUSE
NC score	0.339562 (rank : 122)	θ value	0.000602161 (rank : 115)
Query Neighborhood Hits	376	Target Neighborhood Hits	191	Shared Neighborhood Hits	62
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FARP2_HUMAN
NC score	0.335442 (rank : 123)	θ value	5.08577e-11 (rank : 29)
Query Neighborhood Hits	376	Target Neighborhood Hits	240	Shared Neighborhood Hits	65
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PEX13_HUMAN
NC score	0.324343 (rank : 124)	θ value	0.0431538 (rank : 183)
Query Neighborhood Hits	376	Target Neighborhood Hits	128	Shared Neighborhood Hits	110
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
NC score	0.322690 (rank : 125)	θ value	0.21417 (rank : 222)
Query Neighborhood Hits	376	Target Neighborhood Hits	126	Shared Neighborhood Hits	113
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

NOXO1_MOUSE
NC score	0.320496 (rank : 126)	θ value	0.0330416 (rank : 179)
Query Neighborhood Hits	376	Target Neighborhood Hits	114	Shared Neighborhood Hits	100
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

FGD6_MOUSE
NC score	0.319987 (rank : 127)	θ value	0.0736092 (rank : 195)
Query Neighborhood Hits	376	Target Neighborhood Hits	282	Shared Neighborhood Hits	63
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

BCAR1_MOUSE
NC score	0.319672 (rank : 128)	θ value	0.0736092 (rank : 194)
Query Neighborhood Hits	376	Target Neighborhood Hits	438	Shared Neighborhood Hits	160
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_HUMAN
NC score	0.315685 (rank : 129)	θ value	0.0736092 (rank : 193)
Query Neighborhood Hits	376	Target Neighborhood Hits	554	Shared Neighborhood Hits	162
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ARHGB_HUMAN
NC score	0.315368 (rank : 130)	θ value	0.0252991 (rank : 173)
Query Neighborhood Hits	376	Target Neighborhood Hits	375	Shared Neighborhood Hits	70
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

NEBU_HUMAN
NC score	0.313621 (rank : 131)	θ value	0.00175202 (rank : 131)
Query Neighborhood Hits	376	Target Neighborhood Hits	420	Shared Neighborhood Hits	180
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

RIMB2_HUMAN
NC score	0.313197 (rank : 132)	θ value	0.00175202 (rank : 132)
Query Neighborhood Hits	376	Target Neighborhood Hits	263	Shared Neighborhood Hits	123
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

FARP1_HUMAN
NC score	0.311292 (rank : 133)	θ value	5.62301e-10 (rank : 35)
Query Neighborhood Hits	376	Target Neighborhood Hits	241	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

RIMB2_MOUSE
NC score	0.310738 (rank : 134)	θ value	0.00298849 (rank : 143)
Query Neighborhood Hits	376	Target Neighborhood Hits	246	Shared Neighborhood Hits	119
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

GNRP_HUMAN
NC score	0.307615 (rank : 135)	θ value	0.00175202 (rank : 130)
Query Neighborhood Hits	376	Target Neighborhood Hits	239	Shared Neighborhood Hits	70
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHGC_HUMAN
NC score	0.305813 (rank : 136)	θ value	0.0193708 (rank : 168)
Query Neighborhood Hits	376	Target Neighborhood Hits	351	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

NPHP1_HUMAN
NC score	0.299398 (rank : 137)	θ value	8.99809 (rank : 374)
Query Neighborhood Hits	376	Target Neighborhood Hits	288	Shared Neighborhood Hits	169
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ARHGC_MOUSE
NC score	0.295784 (rank : 138)	θ value	0.0563607 (rank : 186)
Query Neighborhood Hits	376	Target Neighborhood Hits	344	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FGD6_HUMAN
NC score	0.294739 (rank : 139)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	376	Target Neighborhood Hits	237	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

CASL_MOUSE
NC score	0.293856 (rank : 140)	θ value	0.125558 (rank : 201)
Query Neighborhood Hits	376	Target Neighborhood Hits	225	Shared Neighborhood Hits	144
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CASL_HUMAN
NC score	0.293335 (rank : 141)	θ value	0.163984 (rank : 211)
Query Neighborhood Hits	376	Target Neighborhood Hits	259	Shared Neighborhood Hits	145
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

ARHG1_HUMAN
NC score	0.287165 (rank : 142)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	376	Target Neighborhood Hits	176	Shared Neighborhood Hits	52
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHGF_HUMAN
NC score	0.286568 (rank : 143)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	376	Target Neighborhood Hits	214	Shared Neighborhood Hits	60
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ANM2_HUMAN
NC score	0.281856 (rank : 144)	θ value	0.0736092 (rank : 191)
Query Neighborhood Hits	376	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

BCR_HUMAN
NC score	0.279207 (rank : 145)	θ value	0.000461057 (rank : 110)
Query Neighborhood Hits	376	Target Neighborhood Hits	204	Shared Neighborhood Hits	60
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

EFS_MOUSE
NC score	0.277846 (rank : 146)	θ value	8.99809 (rank : 361)
Query Neighborhood Hits	376	Target Neighborhood Hits	389	Shared Neighborhood Hits	148
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EFS_HUMAN
NC score	0.277764 (rank : 147)	θ value	6.88961 (rank : 337)
Query Neighborhood Hits	376	Target Neighborhood Hits	348	Shared Neighborhood Hits	147
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ARHG2_MOUSE
NC score	0.275272 (rank : 148)	θ value	6.88961 (rank : 336)
Query Neighborhood Hits	376	Target Neighborhood Hits	120	Shared Neighborhood Hits	57
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

LBC_HUMAN
NC score	0.274843 (rank : 149)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	376	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

SNX18_MOUSE
NC score	0.270351 (rank : 150)	θ value	0.279714 (rank : 232)
Query Neighborhood Hits	376	Target Neighborhood Hits	198	Shared Neighborhood Hits	124
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SOS1_HUMAN
NC score	0.269464 (rank : 151)	θ value	1.87187e-05 (rank : 82)
Query Neighborhood Hits	376	Target Neighborhood Hits	274	Shared Neighborhood Hits	39
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SHAN2_MOUSE
NC score	0.268327 (rank : 152)	θ value	5.44631e-05 (rank : 92)
Query Neighborhood Hits	376	Target Neighborhood Hits	446	Shared Neighborhood Hits	113
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

RGNEF_MOUSE
NC score	0.267669 (rank : 153)	θ value	0.813845 (rank : 264)
Query Neighborhood Hits	376	Target Neighborhood Hits	641	Shared Neighborhood Hits	121
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ANM2_MOUSE
NC score	0.266123 (rank : 154)	θ value	0.0563607 (rank : 185)
Query Neighborhood Hits	376	Target Neighborhood Hits	175	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SNX18_HUMAN
NC score	0.262325 (rank : 155)	θ value	0.62314 (rank : 256)
Query Neighborhood Hits	376	Target Neighborhood Hits	207	Shared Neighborhood Hits	127
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ABR_HUMAN
NC score	0.260760 (rank : 156)	θ value	0.163984 (rank : 210)
Query Neighborhood Hits	376	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

SOS1_MOUSE
NC score	0.259905 (rank : 157)	θ value	3.19293e-05 (rank : 87)
Query Neighborhood Hits	376	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ARHG2_HUMAN
NC score	0.259726 (rank : 158)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	376	Target Neighborhood Hits	142	Shared Neighborhood Hits	60
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

RHG04_HUMAN
NC score	0.258809 (rank : 159)	θ value	0.365318 (rank : 238)
Query Neighborhood Hits	376	Target Neighborhood Hits	307	Shared Neighborhood Hits	160
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ARHG1_MOUSE
NC score	0.253929 (rank : 160)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	376	Target Neighborhood Hits	266	Shared Neighborhood Hits	50
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

SPTA2_HUMAN
NC score	0.253162 (rank : 161)	θ value	0.000270298 (rank : 107)
Query Neighborhood Hits	376	Target Neighborhood Hits	888	Shared Neighborhood Hits	244
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

IASPP_HUMAN
NC score	0.248920 (rank : 162)	θ value	0.163984 (rank : 212)
Query Neighborhood Hits	376	Target Neighborhood Hits	688	Shared Neighborhood Hits	157
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CNN1_HUMAN
NC score	0.243398 (rank : 163)	θ value	3.41135e-07 (rank : 54)
Query Neighborhood Hits	376	Target Neighborhood Hits	38	Shared Neighborhood Hits	30
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN1_MOUSE
NC score	0.243209 (rank : 164)	θ value	4.45536e-07 (rank : 57)
Query Neighborhood Hits	376	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

ASPP1_HUMAN
NC score	0.242003 (rank : 165)	θ value	0.0563607 (rank : 187)
Query Neighborhood Hits	376	Target Neighborhood Hits	956	Shared Neighborhood Hits	215
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

RHG26_HUMAN
NC score	0.241711 (rank : 166)	θ value	0.000602161 (rank : 116)
Query Neighborhood Hits	376	Target Neighborhood Hits	281	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ASPP1_MOUSE
NC score	0.241293 (rank : 167)	θ value	0.0330416 (rank : 176)
Query Neighborhood Hits	376	Target Neighborhood Hits	1244	Shared Neighborhood Hits	220
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CNN2_MOUSE
NC score	0.240907 (rank : 168)	θ value	1.09739e-05 (rank : 78)
Query Neighborhood Hits	376	Target Neighborhood Hits	39	Shared Neighborhood Hits	30
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

DDEF1_MOUSE
NC score	0.240841 (rank : 169)	θ value	0.00298849 (rank : 141)
Query Neighborhood Hits	376	Target Neighborhood Hits	592	Shared Neighborhood Hits	154
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CNN3_HUMAN
NC score	0.239723 (rank : 170)	θ value	6.43352e-06 (rank : 70)
Query Neighborhood Hits	376	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_MOUSE
NC score	0.239655 (rank : 171)	θ value	6.43352e-06 (rank : 71)
Query Neighborhood Hits	376	Target Neighborhood Hits	45	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

IASPP_MOUSE
NC score	0.238464 (rank : 172)	θ value	0.00869519 (rank : 157)
Query Neighborhood Hits	376	Target Neighborhood Hits	1024	Shared Neighborhood Hits	166
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MYO1E_HUMAN
NC score	0.236562 (rank : 173)	θ value	3.77169e-06 (rank : 69)
Query Neighborhood Hits	376	Target Neighborhood Hits	293	Shared Neighborhood Hits	196
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
NC score	0.236392 (rank : 174)	θ value	7.1131e-05 (rank : 93)
Query Neighborhood Hits	376	Target Neighborhood Hits	275	Shared Neighborhood Hits	199
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.235660 (rank : 175)	θ value	5.44631e-05 (rank : 90)
Query Neighborhood Hits	376	Target Neighborhood Hits	262	Shared Neighborhood Hits	199
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ES8L3_MOUSE
NC score	0.235105 (rank : 176)	θ value	0.813845 (rank : 260)
Query Neighborhood Hits	376	Target Neighborhood Hits	168	Shared Neighborhood Hits	135
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

CNN2_HUMAN
NC score	0.234874 (rank : 177)	θ value	3.19293e-05 (rank : 86)
Query Neighborhood Hits	376	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

NOXO1_HUMAN
NC score	0.231834 (rank : 178)	θ value	6.88961 (rank : 352)
Query Neighborhood Hits	376	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

DDEF2_MOUSE
NC score	0.230878 (rank : 179)	θ value	0.00102713 (rank : 123)
Query Neighborhood Hits	376	Target Neighborhood Hits	625	Shared Neighborhood Hits	160
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SPTA1_MOUSE
NC score	0.230645 (rank : 180)	θ value	0.0148317 (rank : 167)
Query Neighborhood Hits	376	Target Neighborhood Hits	675	Shared Neighborhood Hits	212
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRGP2_MOUSE
NC score	0.230572 (rank : 181)	θ value	0.47712 (rank : 249)
Query Neighborhood Hits	376	Target Neighborhood Hits	324	Shared Neighborhood Hits	169
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.228592 (rank : 182)	θ value	0.365318 (rank : 239)
Query Neighborhood Hits	376	Target Neighborhood Hits	331	Shared Neighborhood Hits	164
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

DDEF2_HUMAN
NC score	0.227706 (rank : 183)	θ value	0.00102713 (rank : 122)
Query Neighborhood Hits	376	Target Neighborhood Hits	599	Shared Neighborhood Hits	165
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

FNBP2_HUMAN
NC score	0.223931 (rank : 184)	θ value	0.279714 (rank : 226)
Query Neighborhood Hits	376	Target Neighborhood Hits	432	Shared Neighborhood Hits	176
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SPTA1_HUMAN
NC score	0.222721 (rank : 185)	θ value	0.0431538 (rank : 184)
Query Neighborhood Hits	376	Target Neighborhood Hits	748	Shared Neighborhood Hits	231
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ES8L3_HUMAN
NC score	0.220632 (rank : 186)	θ value	8.99809 (rank : 362)
Query Neighborhood Hits	376	Target Neighborhood Hits	206	Shared Neighborhood Hits	119
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SRGP1_HUMAN
NC score	0.220457 (rank : 187)	θ value	0.47712 (rank : 248)
Query Neighborhood Hits	376	Target Neighborhood Hits	390	Shared Neighborhood Hits	170
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

TRIO_HUMAN
NC score	0.220381 (rank : 188)	θ value	1.38178e-16 (rank : 15)
Query Neighborhood Hits	376	Target Neighborhood Hits	1580	Shared Neighborhood Hits	186
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SOS2_HUMAN
NC score	0.218124 (rank : 189)	θ value	0.62314 (rank : 257)
Query Neighborhood Hits	376	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

LMO7_HUMAN
NC score	0.213792 (rank : 190)	θ value	4.1701e-05 (rank : 88)
Query Neighborhood Hits	376	Target Neighborhood Hits	507	Shared Neighborhood Hits	92
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

SHAN1_HUMAN
NC score	0.212920 (rank : 191)	θ value	1.99992e-07 (rank : 52)
Query Neighborhood Hits	376	Target Neighborhood Hits	1041	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

BI2L1_HUMAN
NC score	0.207713 (rank : 192)	θ value	0.00869519 (rank : 155)
Query Neighborhood Hits	376	Target Neighborhood Hits	156	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ASPP2_HUMAN
NC score	0.207014 (rank : 193)	θ value	0.125558 (rank : 200)
Query Neighborhood Hits	376	Target Neighborhood Hits	1156	Shared Neighborhood Hits	220
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

FGD5_HUMAN
NC score	0.206414 (rank : 194)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	376	Target Neighborhood Hits	235	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

RIMB1_HUMAN
NC score	0.203459 (rank : 195)	θ value	0.0148317 (rank : 166)
Query Neighborhood Hits	376	Target Neighborhood Hits	1479	Shared Neighborhood Hits	230
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SLY_MOUSE
NC score	0.203419 (rank : 196)	θ value	0.21417 (rank : 223)
Query Neighborhood Hits	376	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

TCGAP_MOUSE
NC score	0.200115 (rank : 197)	θ value	0.125558 (rank : 209)
Query Neighborhood Hits	376	Target Neighborhood Hits	409	Shared Neighborhood Hits	124
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RIMB1_MOUSE
NC score	0.200005 (rank : 198)	θ value	0.00390308 (rank : 146)
Query Neighborhood Hits	376	Target Neighborhood Hits	1376	Shared Neighborhood Hits	236
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SNX9_HUMAN
NC score	0.198803 (rank : 199)	θ value	0.813845 (rank : 266)
Query Neighborhood Hits	376	Target Neighborhood Hits	148	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

ES8L2_HUMAN
NC score	0.198782 (rank : 200)	θ value	0.62314 (rank : 253)
Query Neighborhood Hits	376	Target Neighborhood Hits	193	Shared Neighborhood Hits	121
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

DUET_HUMAN
NC score	0.195842 (rank : 201)	θ value	1.133e-10 (rank : 31)
Query Neighborhood Hits	376	Target Neighborhood Hits	1220	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

STS2_HUMAN
NC score	0.194778 (rank : 202)	θ value	0.163984 (rank : 218)
Query Neighborhood Hits	376	Target Neighborhood Hits	108	Shared Neighborhood Hits	84
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ES8L2_MOUSE
NC score	0.193398 (rank : 203)	θ value	0.47712 (rank : 245)
Query Neighborhood Hits	376	Target Neighborhood Hits	169	Shared Neighborhood Hits	118
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

RUSC1_HUMAN
NC score	0.190494 (rank : 204)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	376	Target Neighborhood Hits	226	Shared Neighborhood Hits	129
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SLY_HUMAN
NC score	0.187517 (rank : 205)	θ value	0.163984 (rank : 217)
Query Neighborhood Hits	376	Target Neighborhood Hits	81	Shared Neighborhood Hits	56
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

EPS8_HUMAN
NC score	0.186270 (rank : 206)	θ value	0.365318 (rank : 235)
Query Neighborhood Hits	376	Target Neighborhood Hits	151	Shared Neighborhood Hits	104
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

FGD5_MOUSE
NC score	0.186028 (rank : 207)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	376	Target Neighborhood Hits	170	Shared Neighborhood Hits	43
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

EPS8_MOUSE
NC score	0.184012 (rank : 208)	θ value	0.813845 (rank : 259)
Query Neighborhood Hits	376	Target Neighborhood Hits	157	Shared Neighborhood Hits	118
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

TAGL3_HUMAN
NC score	0.179750 (rank : 209)	θ value	0.0193708 (rank : 172)
Query Neighborhood Hits	376	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UI15, Q96A74	Gene names	TAGLN3, NP25
Domain Architecture
Description	Transgelin-3 (Neuronal protein NP25) (Neuronal protein 22) (NP22).

TAGL_MOUSE
NC score	0.179723 (rank : 210)	θ value	0.0563607 (rank : 190)
Query Neighborhood Hits	376	Target Neighborhood Hits	33	Shared Neighborhood Hits	29
SwissProt Accessions	P37804, Q545W0	Gene names	Tagln, Sm22, Sm22a
Domain Architecture
Description	Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (Actin- associated protein p27).

TAGL_HUMAN
NC score	0.178356 (rank : 211)	θ value	0.125558 (rank : 208)
Query Neighborhood Hits	376	Target Neighborhood Hits	32	Shared Neighborhood Hits	29
SwissProt Accessions	Q01995, O15542	Gene names	TAGLN, SM22, WS3-10
Domain Architecture
Description	Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (WS3-10) (22 kDa actin-binding protein).

TCGAP_HUMAN
NC score	0.176997 (rank : 212)	θ value	1.06291 (rank : 277)
Query Neighborhood Hits	376	Target Neighborhood Hits	872	Shared Neighborhood Hits	128
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SNX9_MOUSE
NC score	0.176938 (rank : 213)	θ value	1.06291 (rank : 275)
Query Neighborhood Hits	376	Target Neighborhood Hits	141	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPN90_HUMAN
NC score	0.176794 (rank : 214)	θ value	4.03905 (rank : 316)
Query Neighborhood Hits	376	Target Neighborhood Hits	157	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

TAGL3_MOUSE
NC score	0.173697 (rank : 215)	θ value	0.0736092 (rank : 197)
Query Neighborhood Hits	376	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1Q8	Gene names	Tagln3, Np25
Domain Architecture
Description	Transgelin-3 (Neuronal protein NP25).

SLAP2_HUMAN
NC score	0.173310 (rank : 216)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	376	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

FYN_MOUSE
NC score	0.173248 (rank : 217)	θ value	8.40245e-06 (rank : 73)
Query Neighborhood Hits	376	Target Neighborhood Hits	1073	Shared Neighborhood Hits	188
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

RUSC1_MOUSE
NC score	0.172826 (rank : 218)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	376	Target Neighborhood Hits	206	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SLAP2_MOUSE
NC score	0.172117 (rank : 219)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	376	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SHLB1_MOUSE
NC score	0.171851 (rank : 220)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	376	Target Neighborhood Hits	101	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

FGR_HUMAN
NC score	0.170406 (rank : 221)	θ value	0.00020696 (rank : 103)
Query Neighborhood Hits	376	Target Neighborhood Hits	1067	Shared Neighborhood Hits	180
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SHLB1_HUMAN
NC score	0.170159 (rank : 222)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	376	Target Neighborhood Hits	96	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

FYN_HUMAN
NC score	0.169962 (rank : 223)	θ value	8.40245e-06 (rank : 72)
Query Neighborhood Hits	376	Target Neighborhood Hits	1078	Shared Neighborhood Hits	188
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

BI2L1_MOUSE
NC score	0.169238 (rank : 224)	θ value	0.0113563 (rank : 159)
Query Neighborhood Hits	376	Target Neighborhood Hits	197	Shared Neighborhood Hits	71
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SAMN1_HUMAN
NC score	0.167337 (rank : 225)	θ value	0.00509761 (rank : 150)
Query Neighborhood Hits	376	Target Neighborhood Hits	74	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

TAGL2_HUMAN
NC score	0.165886 (rank : 226)	θ value	0.365318 (rank : 240)
Query Neighborhood Hits	376	Target Neighborhood Hits	35	Shared Neighborhood Hits	26
SwissProt Accessions	P37802, Q5JRQ6, Q5JRQ7, Q9BUH5, Q9H4P0	Gene names	TAGLN2, KIAA0120
Domain Architecture
Description	Transgelin-2 (SM22-alpha homolog).

TAGL2_MOUSE
NC score	0.165304 (rank : 227)	θ value	0.47712 (rank : 250)
Query Neighborhood Hits	376	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVA4	Gene names	Tagln2
Domain Architecture
Description	Transgelin-2.

YES_MOUSE
NC score	0.165203 (rank : 228)	θ value	0.00228821 (rank : 140)
Query Neighborhood Hits	376	Target Neighborhood Hits	1052	Shared Neighborhood Hits	181
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.163597 (rank : 229)	θ value	0.0113563 (rank : 163)
Query Neighborhood Hits	376	Target Neighborhood Hits	1059	Shared Neighborhood Hits	183
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

M3KL4_HUMAN
NC score	0.163417 (rank : 230)	θ value	0.000158464 (rank : 100)
Query Neighborhood Hits	376	Target Neighborhood Hits	1087	Shared Neighborhood Hits	198
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

STS1_MOUSE
NC score	0.163049 (rank : 231)	θ value	0.813845 (rank : 267)
Query Neighborhood Hits	376	Target Neighborhood Hits	104	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_HUMAN
NC score	0.161451 (rank : 232)	θ value	1.06291 (rank : 276)
Query Neighborhood Hits	376	Target Neighborhood Hits	106	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SRC_HUMAN
NC score	0.161192 (rank : 233)	θ value	0.00509761 (rank : 151)
Query Neighborhood Hits	376	Target Neighborhood Hits	1058	Shared Neighborhood Hits	184
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FGR_MOUSE
NC score	0.160552 (rank : 234)	θ value	0.0193708 (rank : 170)
Query Neighborhood Hits	376	Target Neighborhood Hits	1069	Shared Neighborhood Hits	181
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLAP1_HUMAN
NC score	0.158999 (rank : 235)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	376	Target Neighborhood Hits	113	Shared Neighborhood Hits	45
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.157811 (rank : 236)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	376	Target Neighborhood Hits	117	Shared Neighborhood Hits	46
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

P85A_MOUSE
NC score	0.156045 (rank : 237)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	376	Target Neighborhood Hits	435	Shared Neighborhood Hits	133
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

M3K11_HUMAN
NC score	0.154442 (rank : 238)	θ value	0.000158464 (rank : 99)
Query Neighborhood Hits	376	Target Neighborhood Hits	1136	Shared Neighborhood Hits	186
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

P85A_HUMAN
NC score	0.153534 (rank : 239)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	376	Target Neighborhood Hits	479	Shared Neighborhood Hits	145
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

M3K9_HUMAN
NC score	0.152884 (rank : 240)	θ value	4.1701e-05 (rank : 89)
Query Neighborhood Hits	376	Target Neighborhood Hits	1123	Shared Neighborhood Hits	194
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

AMPH_HUMAN
NC score	0.150532 (rank : 241)	θ value	1.06291 (rank : 268)
Query Neighborhood Hits	376	Target Neighborhood Hits	455	Shared Neighborhood Hits	111
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

SHLB2_MOUSE
NC score	0.150060 (rank : 242)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	376	Target Neighborhood Hits	88	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ES8L1_HUMAN
NC score	0.149765 (rank : 243)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	376	Target Neighborhood Hits	162	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SHLB2_HUMAN
NC score	0.149170 (rank : 244)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	376	Target Neighborhood Hits	86	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SAMN1_MOUSE
NC score	0.149139 (rank : 245)	θ value	0.0736092 (rank : 196)
Query Neighborhood Hits	376	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

ES8L1_MOUSE
NC score	0.149098 (rank : 246)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	376	Target Neighborhood Hits	143	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

AMPH_MOUSE
NC score	0.146784 (rank : 247)	θ value	0.365318 (rank : 233)
Query Neighborhood Hits	376	Target Neighborhood Hits	291	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BTK_HUMAN
NC score	0.146570 (rank : 248)	θ value	0.00869519 (rank : 156)
Query Neighborhood Hits	376	Target Neighborhood Hits	1026	Shared Neighborhood Hits	178
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SASH1_HUMAN
NC score	0.146084 (rank : 249)	θ value	0.163984 (rank : 216)
Query Neighborhood Hits	376	Target Neighborhood Hits	292	Shared Neighborhood Hits	64
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

HCK_MOUSE
NC score	0.145509 (rank : 250)	θ value	0.00102713 (rank : 124)
Query Neighborhood Hits	376	Target Neighborhood Hits	1029	Shared Neighborhood Hits	172
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

P85B_HUMAN
NC score	0.143903 (rank : 251)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	376	Target Neighborhood Hits	543	Shared Neighborhood Hits	139
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SRC_MOUSE
NC score	0.143202 (rank : 252)	θ value	0.0563607 (rank : 189)
Query Neighborhood Hits	376	Target Neighborhood Hits	1033	Shared Neighborhood Hits	164
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HCK_HUMAN
NC score	0.142908 (rank : 253)	θ value	9.29e-05 (rank : 94)
Query Neighborhood Hits	376	Target Neighborhood Hits	1035	Shared Neighborhood Hits	173
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SASH1_MOUSE
NC score	0.140785 (rank : 254)	θ value	0.125558 (rank : 207)
Query Neighborhood Hits	376	Target Neighborhood Hits	263	Shared Neighborhood Hits	58
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

P85B_MOUSE
NC score	0.140033 (rank : 255)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	376	Target Neighborhood Hits	519	Shared Neighborhood Hits	137
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

BTK_MOUSE
NC score	0.139719 (rank : 256)	θ value	0.0330416 (rank : 178)
Query Neighborhood Hits	376	Target Neighborhood Hits	1017	Shared Neighborhood Hits	168
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

EM55_HUMAN
NC score	0.137390 (rank : 257)	θ value	0.47712 (rank : 243)
Query Neighborhood Hits	376	Target Neighborhood Hits	228	Shared Neighborhood Hits	89
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

M3K10_HUMAN
NC score	0.135438 (rank : 258)	θ value	0.00228821 (rank : 138)
Query Neighborhood Hits	376	Target Neighborhood Hits	1071	Shared Neighborhood Hits	180
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

SPN90_MOUSE
NC score	0.135321 (rank : 259)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	376	Target Neighborhood Hits	157	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

RASA1_HUMAN
NC score	0.134782 (rank : 260)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	376	Target Neighborhood Hits	258	Shared Neighborhood Hits	69
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

LYN_HUMAN
NC score	0.134561 (rank : 261)	θ value	0.0563607 (rank : 188)
Query Neighborhood Hits	376	Target Neighborhood Hits	1022	Shared Neighborhood Hits	157
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FRK_HUMAN
NC score	0.133737 (rank : 262)	θ value	0.47712 (rank : 246)
Query Neighborhood Hits	376	Target Neighborhood Hits	1058	Shared Neighborhood Hits	178
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

EM55_MOUSE
NC score	0.133528 (rank : 263)	θ value	0.47712 (rank : 244)
Query Neighborhood Hits	376	Target Neighborhood Hits	221	Shared Neighborhood Hits	88
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

LYN_MOUSE
NC score	0.133334 (rank : 264)	θ value	0.125558 (rank : 205)
Query Neighborhood Hits	376	Target Neighborhood Hits	1023	Shared Neighborhood Hits	156
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

DOCK1_HUMAN
NC score	0.133154 (rank : 265)	θ value	2.36792 (rank : 289)
Query Neighborhood Hits	376	Target Neighborhood Hits	191	Shared Neighborhood Hits	120
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

BLK_HUMAN
NC score	0.131297 (rank : 266)	θ value	0.0330416 (rank : 177)
Query Neighborhood Hits	376	Target Neighborhood Hits	994	Shared Neighborhood Hits	142
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
NC score	0.131103 (rank : 267)	θ value	0.00134147 (rank : 126)
Query Neighborhood Hits	376	Target Neighborhood Hits	992	Shared Neighborhood Hits	132
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CIP4_HUMAN
NC score	0.129905 (rank : 268)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	376	Target Neighborhood Hits	374	Shared Neighborhood Hits	123
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

PTK6_MOUSE
NC score	0.129230 (rank : 269)	θ value	0.00509761 (rank : 149)
Query Neighborhood Hits	376	Target Neighborhood Hits	1026	Shared Neighborhood Hits	155
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

CSK_MOUSE
NC score	0.127526 (rank : 270)	θ value	0.00228821 (rank : 136)
Query Neighborhood Hits	376	Target Neighborhood Hits	1009	Shared Neighborhood Hits	141
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.127185 (rank : 271)	θ value	0.00228821 (rank : 135)
Query Neighborhood Hits	376	Target Neighborhood Hits	1009	Shared Neighborhood Hits	141
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

DAPP1_HUMAN
NC score	0.126357 (rank : 272)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PTK6_HUMAN
NC score	0.125644 (rank : 273)	θ value	0.0113563 (rank : 162)
Query Neighborhood Hits	376	Target Neighborhood Hits	1020	Shared Neighborhood Hits	160
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

DAPP1_MOUSE
NC score	0.125644 (rank : 274)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	376	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ABL1_MOUSE
NC score	0.122704 (rank : 275)	θ value	0.00102713 (rank : 121)
Query Neighborhood Hits	376	Target Neighborhood Hits	1178	Shared Neighborhood Hits	134
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

P55G_HUMAN
NC score	0.122623 (rank : 276)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	376	Target Neighborhood Hits	451	Shared Neighborhood Hits	110
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

ABL1_HUMAN
NC score	0.122603 (rank : 277)	θ value	0.00102713 (rank : 120)
Query Neighborhood Hits	376	Target Neighborhood Hits	1220	Shared Neighborhood Hits	137
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BAIP2_MOUSE
NC score	0.121789 (rank : 278)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	376	Target Neighborhood Hits	185	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAIP2_HUMAN
NC score	0.121021 (rank : 279)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	376	Target Neighborhood Hits	192	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

MPP6_HUMAN
NC score	0.120576 (rank : 280)	θ value	1.06291 (rank : 274)
Query Neighborhood Hits	376	Target Neighborhood Hits	180	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

P55G_MOUSE
NC score	0.119312 (rank : 281)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	376	Target Neighborhood Hits	401	Shared Neighborhood Hits	107
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

MPP6_MOUSE
NC score	0.118714 (rank : 282)	θ value	0.21417 (rank : 221)
Query Neighborhood Hits	376	Target Neighborhood Hits	187	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

ABL2_HUMAN
NC score	0.117859 (rank : 283)	θ value	0.0330416 (rank : 175)
Query Neighborhood Hits	376	Target Neighborhood Hits	1045	Shared Neighborhood Hits	121
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

BIN1_MOUSE
NC score	0.116050 (rank : 284)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	376	Target Neighborhood Hits	283	Shared Neighborhood Hits	96
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

FUT8_HUMAN
NC score	0.115848 (rank : 285)	θ value	1.06291 (rank : 270)
Query Neighborhood Hits	376	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

TEC_HUMAN
NC score	0.115699 (rank : 286)	θ value	0.47712 (rank : 251)
Query Neighborhood Hits	376	Target Neighborhood Hits	1006	Shared Neighborhood Hits	139
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BIN1_HUMAN
NC score	0.115606 (rank : 287)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	376	Target Neighborhood Hits	335	Shared Neighborhood Hits	92
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

FUT8_MOUSE
NC score	0.113843 (rank : 288)	θ value	0.62314 (rank : 254)
Query Neighborhood Hits	376	Target Neighborhood Hits	115	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

SHE_MOUSE
NC score	0.113066 (rank : 289)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	376	Target Neighborhood Hits	169	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

LCK_HUMAN
NC score	0.112241 (rank : 290)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	376	Target Neighborhood Hits	987	Shared Neighborhood Hits	122
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

TXK_MOUSE
NC score	0.112166 (rank : 291)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	376	Target Neighborhood Hits	980	Shared Neighborhood Hits	144
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LCK_MOUSE
NC score	0.111590 (rank : 292)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	376	Target Neighborhood Hits	981	Shared Neighborhood Hits	122
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

TEC_MOUSE
NC score	0.111575 (rank : 293)	θ value	1.06291 (rank : 278)
Query Neighborhood Hits	376	Target Neighborhood Hits	1006	Shared Neighborhood Hits	140
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ALS2_MOUSE
NC score	0.111366 (rank : 294)	θ value	2.44474e-05 (rank : 83)
Query Neighborhood Hits	376	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SH21B_MOUSE
NC score	0.110183 (rank : 295)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	376	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHE_HUMAN
NC score	0.109617 (rank : 296)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	376	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

OBSCN_HUMAN
NC score	0.107403 (rank : 297)	θ value	9.29e-05 (rank : 95)
Query Neighborhood Hits	376	Target Neighborhood Hits	1931	Shared Neighborhood Hits	107
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SHB_MOUSE
NC score	0.107228 (rank : 298)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	376	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

APS_HUMAN
NC score	0.106857 (rank : 299)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	376	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

TXK_HUMAN
NC score	0.106636 (rank : 300)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	376	Target Neighborhood Hits	971	Shared Neighborhood Hits	128
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ALS2_HUMAN
NC score	0.106530 (rank : 301)	θ value	0.000270298 (rank : 106)
Query Neighborhood Hits	376	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

SHC3_MOUSE
NC score	0.104497 (rank : 302)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	376	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHB_HUMAN
NC score	0.104491 (rank : 303)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	376	Target Neighborhood Hits	141	Shared Neighborhood Hits	45
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_MOUSE
NC score	0.103430 (rank : 304)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	376	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ITK_HUMAN
NC score	0.103244 (rank : 305)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	376	Target Neighborhood Hits	1016	Shared Neighborhood Hits	136
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SHC1_HUMAN
NC score	0.102294 (rank : 306)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	376	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
NC score	0.101817 (rank : 307)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	376	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHD_HUMAN
NC score	0.101609 (rank : 308)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	376	Target Neighborhood Hits	204	Shared Neighborhood Hits	44
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SH21B_HUMAN
NC score	0.101410 (rank : 309)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	376	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHC2_HUMAN
NC score	0.100657 (rank : 310)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	376	Target Neighborhood Hits	170	Shared Neighborhood Hits	49
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

GRB14_MOUSE
NC score	0.099953 (rank : 311)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	376	Target Neighborhood Hits	149	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

LNK_HUMAN
NC score	0.098861 (rank : 312)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	376	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SHC2_MOUSE
NC score	0.098576 (rank : 313)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	376	Target Neighborhood Hits	144	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

GRB14_HUMAN
NC score	0.098287 (rank : 314)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	376	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

LRCH1_HUMAN
NC score	0.097730 (rank : 315)	θ value	0.0113563 (rank : 160)
Query Neighborhood Hits	376	Target Neighborhood Hits	266	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y2L9, Q7Z5F6, Q7Z5F7	Gene names	LRCH1, CHDC1, KIAA1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81).

SHC3_HUMAN
NC score	0.096802 (rank : 316)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	376	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

ITK_MOUSE
NC score	0.096667 (rank : 317)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	376	Target Neighborhood Hits	985	Shared Neighborhood Hits	120
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LNK_MOUSE
NC score	0.096530 (rank : 318)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	376	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SH24A_HUMAN
NC score	0.095101 (rank : 319)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	376	Target Neighborhood Hits	455	Shared Neighborhood Hits	94
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SRMS_MOUSE
NC score	0.092861 (rank : 320)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	376	Target Neighborhood Hits	964	Shared Neighborhood Hits	109
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

MPP2_MOUSE
NC score	0.092617 (rank : 321)	θ value	1.81305 (rank : 285)
Query Neighborhood Hits	376	Target Neighborhood Hits	189	Shared Neighborhood Hits	65
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

HSH2D_HUMAN
NC score	0.092180 (rank : 322)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	376	Target Neighborhood Hits	159	Shared Neighborhood Hits	36
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

JIP2_MOUSE
NC score	0.090477 (rank : 323)	θ value	1.81305 (rank : 284)
Query Neighborhood Hits	376	Target Neighborhood Hits	144	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

GRB7_MOUSE
NC score	0.090234 (rank : 324)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	376	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

MPP2_HUMAN
NC score	0.089218 (rank : 325)	θ value	8.99809 (rank : 367)
Query Neighborhood Hits	376	Target Neighborhood Hits	173	Shared Neighborhood Hits	65
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

LRCH1_MOUSE
NC score	0.088960 (rank : 326)	θ value	0.163984 (rank : 213)
Query Neighborhood Hits	376	Target Neighborhood Hits	264	Shared Neighborhood Hits	37
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

JIP2_HUMAN
NC score	0.088663 (rank : 327)	θ value	4.03905 (rank : 312)
Query Neighborhood Hits	376	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SRMS_HUMAN
NC score	0.086523 (rank : 328)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	376	Target Neighborhood Hits	946	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

LRCH2_HUMAN
NC score	0.085523 (rank : 329)	θ value	0.125558 (rank : 203)
Query Neighborhood Hits	376	Target Neighborhood Hits	315	Shared Neighborhood Hits	35
SwissProt Accessions	Q5VUJ6, Q9HA88, Q9P233	Gene names	LRCH2, KIAA1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

SH21A_HUMAN
NC score	0.084888 (rank : 330)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	376	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

MATK_MOUSE
NC score	0.084721 (rank : 331)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	376	Target Neighborhood Hits	952	Shared Neighborhood Hits	88
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

SH21A_MOUSE
NC score	0.084626 (rank : 332)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	376	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

LRCH2_MOUSE
NC score	0.083358 (rank : 333)	θ value	0.163984 (rank : 214)
Query Neighborhood Hits	376	Target Neighborhood Hits	287	Shared Neighborhood Hits	30
SwissProt Accessions	Q3UMG5, Q7TNP9, Q80TC9	Gene names	Lrch2, Kiaa1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

MATK_HUMAN
NC score	0.083332 (rank : 334)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	376	Target Neighborhood Hits	954	Shared Neighborhood Hits	83
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

PKHF2_MOUSE
NC score	0.083319 (rank : 335)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	376	Target Neighborhood Hits	77	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.083271 (rank : 336)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	376	Target Neighborhood Hits	75	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

MPP5_HUMAN
NC score	0.082552 (rank : 337)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	376	Target Neighborhood Hits	231	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

LRCH3_HUMAN
NC score	0.082451 (rank : 338)	θ value	0.125558 (rank : 204)
Query Neighborhood Hits	376	Target Neighborhood Hits	270	Shared Neighborhood Hits	31
SwissProt Accessions	Q96II8, Q96FP9, Q9NT52	Gene names	LRCH3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

MPP5_MOUSE
NC score	0.082016 (rank : 339)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	376	Target Neighborhood Hits	226	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

LRCH3_MOUSE
NC score	0.081831 (rank : 340)	θ value	0.279714 (rank : 228)
Query Neighborhood Hits	376	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

EEA1_MOUSE
NC score	0.081505 (rank : 341)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	376	Target Neighborhood Hits	1637	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

PKHF1_HUMAN
NC score	0.080682 (rank : 342)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	376	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

GRB7_HUMAN
NC score	0.080139 (rank : 343)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	376	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

JIP1_MOUSE
NC score	0.080054 (rank : 344)	θ value	6.88961 (rank : 343)
Query Neighborhood Hits	376	Target Neighborhood Hits	259	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

CHIN_MOUSE
NC score	0.078987 (rank : 345)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	376	Target Neighborhood Hits	229	Shared Neighborhood Hits	53
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

FER_HUMAN
NC score	0.077793 (rank : 346)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	376	Target Neighborhood Hits	1278	Shared Neighborhood Hits	143
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CCD46_HUMAN
NC score	0.077655 (rank : 347)	θ value	0.279714 (rank : 225)
Query Neighborhood Hits	376	Target Neighborhood Hits	1430	Shared Neighborhood Hits	128
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CHIN_HUMAN
NC score	0.077510 (rank : 348)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

PTN11_MOUSE
NC score	0.077366 (rank : 349)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.077355 (rank : 350)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	376	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

APS_MOUSE
NC score	0.077100 (rank : 351)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	376	Target Neighborhood Hits	134	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GRB10_MOUSE
NC score	0.076724 (rank : 352)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	376	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB10_HUMAN
NC score	0.076475 (rank : 353)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	376	Target Neighborhood Hits	147	Shared Neighborhood Hits	46
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

PKHF1_MOUSE
NC score	0.076356 (rank : 354)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	376	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SH22A_MOUSE
NC score	0.075822 (rank : 355)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	376	Target Neighborhood Hits	179	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

CSKP_HUMAN
NC score	0.075348 (rank : 356)	θ value	0.000602161 (rank : 114)
Query Neighborhood Hits	376	Target Neighborhood Hits	1022	Shared Neighborhood Hits	123
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CHIO_HUMAN
NC score	0.075096 (rank : 357)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	376	Target Neighborhood Hits	220	Shared Neighborhood Hits	50
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CCD46_MOUSE
NC score	0.074894 (rank : 358)	θ value	0.125558 (rank : 202)
Query Neighborhood Hits	376	Target Neighborhood Hits	1405	Shared Neighborhood Hits	130
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

PPIP2_HUMAN
NC score	0.074417 (rank : 359)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	376	Target Neighborhood Hits	254	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

JIP1_HUMAN
NC score	0.074287 (rank : 360)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	376	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LRCH4_MOUSE
NC score	0.074234 (rank : 361)	θ value	0.21417 (rank : 220)
Query Neighborhood Hits	376	Target Neighborhood Hits	302	Shared Neighborhood Hits	33
SwissProt Accessions	Q921G6	Gene names	Lrch4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4.

CCD91_HUMAN
NC score	0.073858 (rank : 362)	θ value	0.21417 (rank : 219)
Query Neighborhood Hits	376	Target Neighborhood Hits	868	Shared Neighborhood Hits	99
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

RUSC2_HUMAN
NC score	0.073427 (rank : 363)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	376	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

EP15_MOUSE
NC score	0.073424 (rank : 364)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	376	Target Neighborhood Hits	820	Shared Neighborhood Hits	100
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EEA1_HUMAN
NC score	0.073038 (rank : 365)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	376	Target Neighborhood Hits	1796	Shared Neighborhood Hits	138
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

SH2D3_MOUSE
NC score	0.072964 (rank : 366)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	376	Target Neighborhood Hits	174	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

BMX_HUMAN
NC score	0.072943 (rank : 367)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	376	Target Neighborhood Hits	942	Shared Neighborhood Hits	61
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.072821 (rank : 368)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	376	Target Neighborhood Hits	912	Shared Neighborhood Hits	61
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

LCP2_MOUSE
NC score	0.072561 (rank : 369)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	376	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

ZAP70_MOUSE
NC score	0.072361 (rank : 370)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	376	Target Neighborhood Hits	905	Shared Neighborhood Hits	63
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

TEX14_MOUSE
NC score	0.072306 (rank : 371)	θ value	1.06291 (rank : 279)
Query Neighborhood Hits	376	Target Neighborhood Hits	1333	Shared Neighborhood Hits	111
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

CSKP_MOUSE
NC score	0.072260 (rank : 372)	θ value	0.00665767 (rank : 152)
Query Neighborhood Hits	376	Target Neighborhood Hits	1027	Shared Neighborhood Hits	129
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

ZAP70_HUMAN
NC score	0.072175 (rank : 373)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	376	Target Neighborhood Hits	893	Shared Neighborhood Hits	64
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

KSYK_MOUSE
NC score	0.071812 (rank : 374)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	376	Target Neighborhood Hits	944	Shared Neighborhood Hits	65
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LRCH4_HUMAN
NC score	0.071590 (rank : 375)	θ value	0.365318 (rank : 237)
Query Neighborhood Hits	376	Target Neighborhood Hits	305	Shared Neighborhood Hits	26
SwissProt Accessions	O75427, Q8WV85, Q96ID0	Gene names	LRCH4, LRN, LRRN4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4 (Leucine-rich neuronal protein).

EP15R_MOUSE
NC score	0.071535 (rank : 376)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	376	Target Neighborhood Hits	1135	Shared Neighborhood Hits	109
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
NC score	0.071177 (rank : 377)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	376	Target Neighborhood Hits	1021	Shared Neighborhood Hits	110
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

KSYK_HUMAN
NC score	0.070554 (rank : 378)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	376	Target Neighborhood Hits	901	Shared Neighborhood Hits	63
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SYCP1_MOUSE
NC score	0.070245 (rank : 379)	θ value	0.21417 (rank : 224)
Query Neighborhood Hits	376	Target Neighborhood Hits	1456	Shared Neighborhood Hits	125
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

RUSC2_MOUSE
NC score	0.070200 (rank : 380)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	376	Target Neighborhood Hits	305	Shared Neighborhood Hits	62
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

MY18A_HUMAN
NC score	0.070014 (rank : 381)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	376	Target Neighborhood Hits	1929	Shared Neighborhood Hits	147
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

EP15R_HUMAN
NC score	0.069599 (rank : 382)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	376	Target Neighborhood Hits	1083	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

MYH9_HUMAN
NC score	0.069218 (rank : 383)	θ value	0.813845 (rank : 263)
Query Neighborhood Hits	376	Target Neighborhood Hits	1762	Shared Neighborhood Hits	144
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SMC3_HUMAN
NC score	0.069048 (rank : 384)	θ value	1.81305 (rank : 287)
Query Neighborhood Hits	376	Target Neighborhood Hits	1186	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

GOGA4_HUMAN
NC score	0.069039 (rank : 385)	θ value	1.06291 (rank : 271)
Query Neighborhood Hits	376	Target Neighborhood Hits	2034	Shared Neighborhood Hits	145
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

SMC3_MOUSE
NC score	0.068931 (rank : 386)	θ value	1.81305 (rank : 288)
Query Neighborhood Hits	376	Target Neighborhood Hits	1187	Shared Neighborhood Hits	112
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

PPIP2_MOUSE
NC score	0.068272 (rank : 387)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	376	Target Neighborhood Hits	308	Shared Neighborhood Hits	64
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

MYH11_HUMAN
NC score	0.068232 (rank : 388)	θ value	3.0926 (rank : 302)
Query Neighborhood Hits	376	Target Neighborhood Hits	1806	Shared Neighborhood Hits	140
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PCNT_HUMAN
NC score	0.068132 (rank : 389)	θ value	2.36792 (rank : 292)
Query Neighborhood Hits	376	Target Neighborhood Hits	1551	Shared Neighborhood Hits	135
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

MYH8_HUMAN
NC score	0.067999 (rank : 390)	θ value	1.81305 (rank : 286)
Query Neighborhood Hits	376	Target Neighborhood Hits	1610	Shared Neighborhood Hits	135
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SH2D3_HUMAN
NC score	0.067924 (rank : 391)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	376	Target Neighborhood Hits	188	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

TRIPB_HUMAN
NC score	0.067691 (rank : 392)	θ value	5.27518 (rank : 335)
Query Neighborhood Hits	376	Target Neighborhood Hits	1587	Shared Neighborhood Hits	136
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

MYH9_MOUSE
NC score	0.067657 (rank : 393)	θ value	0.62314 (rank : 255)
Query Neighborhood Hits	376	Target Neighborhood Hits	1829	Shared Neighborhood Hits	141
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SH24A_MOUSE
NC score	0.067341 (rank : 394)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	376	Target Neighborhood Hits	326	Shared Neighborhood Hits	62
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

FLIP1_HUMAN
NC score	0.067053 (rank : 395)	θ value	6.88961 (rank : 338)
Query Neighborhood Hits	376	Target Neighborhood Hits	1405	Shared Neighborhood Hits	136
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

REPS2_HUMAN
NC score	0.066982 (rank : 396)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	376	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

MYH8_MOUSE
NC score	0.066794 (rank : 397)	θ value	5.27518 (rank : 329)
Query Neighborhood Hits	376	Target Neighborhood Hits	1600	Shared Neighborhood Hits	133
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

CENPF_HUMAN
NC score	0.066784 (rank : 398)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	376	Target Neighborhood Hits	1932	Shared Neighborhood Hits	142
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

MYH6_MOUSE
NC score	0.066679 (rank : 399)	θ value	3.0926 (rank : 304)
Query Neighborhood Hits	376	Target Neighborhood Hits	1501	Shared Neighborhood Hits	133
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

REPS2_MOUSE
NC score	0.066535 (rank : 400)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	376	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

LCP2_HUMAN
NC score	0.066508 (rank : 401)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	376	Target Neighborhood Hits	531	Shared Neighborhood Hits	50
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MPP4_MOUSE
NC score	0.066507 (rank : 402)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	376	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PTN6_MOUSE
NC score	0.066404 (rank : 403)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	376	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

MYH7_HUMAN
NC score	0.066193 (rank : 404)	θ value	2.36792 (rank : 291)
Query Neighborhood Hits	376	Target Neighborhood Hits	1559	Shared Neighborhood Hits	127
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MY18A_MOUSE
NC score	0.066169 (rank : 405)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	376	Target Neighborhood Hits	1989	Shared Neighborhood Hits	147
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH11_MOUSE
NC score	0.066155 (rank : 406)	θ value	3.0926 (rank : 303)
Query Neighborhood Hits	376	Target Neighborhood Hits	1777	Shared Neighborhood Hits	138
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH10_MOUSE
NC score	0.066086 (rank : 407)	θ value	5.27518 (rank : 326)
Query Neighborhood Hits	376	Target Neighborhood Hits	1612	Shared Neighborhood Hits	136
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PTN6_HUMAN
NC score	0.065868 (rank : 408)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	376	Target Neighborhood Hits	234	Shared Neighborhood Hits	51
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SMC1A_MOUSE
NC score	0.065722 (rank : 409)	θ value	0.279714 (rank : 231)
Query Neighborhood Hits	376	Target Neighborhood Hits	1384	Shared Neighborhood Hits	124
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

MYH10_HUMAN
NC score	0.065722 (rank : 410)	θ value	5.27518 (rank : 325)
Query Neighborhood Hits	376	Target Neighborhood Hits	1620	Shared Neighborhood Hits	136
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

SOCS7_MOUSE
NC score	0.065717 (rank : 411)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	376	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

MYH3_HUMAN
NC score	0.065634 (rank : 412)	θ value	8.99809 (rank : 370)
Query Neighborhood Hits	376	Target Neighborhood Hits	1660	Shared Neighborhood Hits	137
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

SMC1A_HUMAN
NC score	0.065515 (rank : 413)	θ value	0.279714 (rank : 230)
Query Neighborhood Hits	376	Target Neighborhood Hits	1346	Shared Neighborhood Hits	123
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SH22A_HUMAN
NC score	0.065508 (rank : 414)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	376	Target Neighborhood Hits	144	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

MYH13_HUMAN
NC score	0.065482 (rank : 415)	θ value	6.88961 (rank : 346)
Query Neighborhood Hits	376	Target Neighborhood Hits	1504	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH1_HUMAN
NC score	0.065433 (rank : 416)	θ value	8.99809 (rank : 368)
Query Neighborhood Hits	376	Target Neighborhood Hits	1478	Shared Neighborhood Hits	130
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH2_HUMAN
NC score	0.065407 (rank : 417)	θ value	6.88961 (rank : 347)
Query Neighborhood Hits	376	Target Neighborhood Hits	1491	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH1_MOUSE
NC score	0.065303 (rank : 418)	θ value	8.99809 (rank : 369)
Query Neighborhood Hits	376	Target Neighborhood Hits	1461	Shared Neighborhood Hits	129
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

CE152_HUMAN
NC score	0.065227 (rank : 419)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	376	Target Neighborhood Hits	976	Shared Neighborhood Hits	111
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

TEX14_HUMAN
NC score	0.065099 (rank : 420)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	376	Target Neighborhood Hits	1103	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ACK1_MOUSE
NC score	0.065060 (rank : 421)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	376	Target Neighborhood Hits	1080	Shared Neighborhood Hits	89
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

GOGB1_HUMAN
NC score	0.064945 (rank : 422)	θ value	8.99809 (rank : 363)
Query Neighborhood Hits	376	Target Neighborhood Hits	2297	Shared Neighborhood Hits	154
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ACK1_HUMAN
NC score	0.064880 (rank : 423)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	376	Target Neighborhood Hits	1140	Shared Neighborhood Hits	85
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

RUFY2_HUMAN
NC score	0.064632 (rank : 424)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	376	Target Neighborhood Hits	1208	Shared Neighborhood Hits	116
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

BCAR3_HUMAN
NC score	0.064528 (rank : 425)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	376	Target Neighborhood Hits	129	Shared Neighborhood Hits	37
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

HSH2D_MOUSE
NC score	0.064430 (rank : 426)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	376	Target Neighborhood Hits	124	Shared Neighborhood Hits	27
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

GRP3_HUMAN
NC score	0.064335 (rank : 427)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	376	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HOOK3_MOUSE
NC score	0.064109 (rank : 428)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	376	Target Neighborhood Hits	1007	Shared Neighborhood Hits	119
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

SYNE1_HUMAN
NC score	0.064085 (rank : 429)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	376	Target Neighborhood Hits	1484	Shared Neighborhood Hits	131
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

BCAR3_MOUSE
NC score	0.064039 (rank : 430)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	376	Target Neighborhood Hits	127	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

MYH6_HUMAN
NC score	0.063929 (rank : 431)	θ value	5.27518 (rank : 328)
Query Neighborhood Hits	376	Target Neighborhood Hits	1426	Shared Neighborhood Hits	125
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

HOOK3_HUMAN
NC score	0.063909 (rank : 432)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	376	Target Neighborhood Hits	1070	Shared Neighborhood Hits	123
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

MYH4_MOUSE
NC score	0.063683 (rank : 433)	θ value	5.27518 (rank : 327)
Query Neighborhood Hits	376	Target Neighborhood Hits	1476	Shared Neighborhood Hits	133
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

SOCS6_MOUSE
NC score	0.063655 (rank : 434)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	376	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

PLCB4_HUMAN
NC score	0.063635 (rank : 435)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	376	Target Neighborhood Hits	658	Shared Neighborhood Hits	86
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

SPTB2_HUMAN
NC score	0.063423 (rank : 436)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	376	Target Neighborhood Hits	748	Shared Neighborhood Hits	111
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.063320 (rank : 437)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	376	Target Neighborhood Hits	770	Shared Neighborhood Hits	114
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

CEP63_HUMAN
NC score	0.063300 (rank : 438)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	376	Target Neighborhood Hits	1005	Shared Neighborhood Hits	112
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

SOCS6_HUMAN
NC score	0.063200 (rank : 439)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	376	Target Neighborhood Hits	126	Shared Neighborhood Hits	34
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

GRAP1_MOUSE
NC score	0.063160 (rank : 440)	θ value	1.06291 (rank : 272)
Query Neighborhood Hits	376	Target Neighborhood Hits	1234	Shared Neighborhood Hits	114
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

MACF4_HUMAN
NC score	0.062534 (rank : 441)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	376	Target Neighborhood Hits	1321	Shared Neighborhood Hits	121
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

GOGA3_MOUSE
NC score	0.062285 (rank : 442)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	376	Target Neighborhood Hits	1437	Shared Neighborhood Hits	126
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

NUMA1_HUMAN
NC score	0.062238 (rank : 443)	θ value	6.88961 (rank : 353)
Query Neighborhood Hits	376	Target Neighborhood Hits	1523	Shared Neighborhood Hits	128
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

PEPL_MOUSE
NC score	0.062233 (rank : 444)	θ value	2.36792 (rank : 294)
Query Neighborhood Hits	376	Target Neighborhood Hits	1105	Shared Neighborhood Hits	117
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

BPAEA_HUMAN
NC score	0.061968 (rank : 445)	θ value	0.365318 (rank : 234)
Query Neighborhood Hits	376	Target Neighborhood Hits	1369	Shared Neighborhood Hits	119
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

AZI1_HUMAN
NC score	0.061898 (rank : 446)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	376	Target Neighborhood Hits	1000	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CCD41_MOUSE
NC score	0.061604 (rank : 447)	θ value	5.27518 (rank : 319)
Query Neighborhood Hits	376	Target Neighborhood Hits	1399	Shared Neighborhood Hits	118
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

SM1L2_HUMAN
NC score	0.061560 (rank : 448)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	376	Target Neighborhood Hits	1019	Shared Neighborhood Hits	107
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

CP250_HUMAN
NC score	0.061525 (rank : 449)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	376	Target Neighborhood Hits	1805	Shared Neighborhood Hits	135
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

RAD50_MOUSE
NC score	0.061458 (rank : 450)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	376	Target Neighborhood Hits	1366	Shared Neighborhood Hits	121
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

CAF1A_MOUSE
NC score	0.061244 (rank : 451)	θ value	1.81305 (rank : 282)
Query Neighborhood Hits	376	Target Neighborhood Hits	736	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CE290_HUMAN
NC score	0.061121 (rank : 452)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	376	Target Neighborhood Hits	1553	Shared Neighborhood Hits	125
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

HMMR_MOUSE
NC score	0.061054 (rank : 453)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	376	Target Neighborhood Hits	1178	Shared Neighborhood Hits	116
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

SWP70_HUMAN
NC score	0.061050 (rank : 454)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	376	Target Neighborhood Hits	973	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GRAP1_HUMAN
NC score	0.061002 (rank : 455)	θ value	0.813845 (rank : 261)
Query Neighborhood Hits	376	Target Neighborhood Hits	944	Shared Neighborhood Hits	106
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

REN3B_HUMAN
NC score	0.060806 (rank : 456)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	376	Target Neighborhood Hits	412	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

SH23A_HUMAN
NC score	0.060761 (rank : 457)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	376	Target Neighborhood Hits	149	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

CP250_MOUSE
NC score	0.060692 (rank : 458)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	376	Target Neighborhood Hits	1583	Shared Neighborhood Hits	132
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

MPP4_HUMAN
NC score	0.060604 (rank : 459)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	376	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

PIBF1_HUMAN
NC score	0.060456 (rank : 460)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	376	Target Neighborhood Hits	1041	Shared Neighborhood Hits	111
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

SM1L2_MOUSE
NC score	0.060446 (rank : 461)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	376	Target Neighborhood Hits	918	Shared Neighborhood Hits	109
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

CI093_HUMAN
NC score	0.060148 (rank : 462)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	376	Target Neighborhood Hits	1088	Shared Neighborhood Hits	111
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

EVPL_HUMAN
NC score	0.059997 (rank : 463)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	376	Target Neighborhood Hits	895	Shared Neighborhood Hits	107
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

EVPL_MOUSE
NC score	0.059946 (rank : 464)	θ value	1.06291 (rank : 269)
Query Neighborhood Hits	376	Target Neighborhood Hits	952	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

FLIP1_MOUSE
NC score	0.059895 (rank : 465)	θ value	6.88961 (rank : 339)
Query Neighborhood Hits	376	Target Neighborhood Hits	1176	Shared Neighborhood Hits	122
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGA4_MOUSE
NC score	0.059874 (rank : 466)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	376	Target Neighborhood Hits	1939	Shared Neighborhood Hits	136
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

SKIL_MOUSE
NC score	0.059790 (rank : 467)	θ value	0.813845 (rank : 265)
Query Neighborhood Hits	376	Target Neighborhood Hits	719	Shared Neighborhood Hits	93
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SWP70_MOUSE
NC score	0.059736 (rank : 468)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	376	Target Neighborhood Hits	1097	Shared Neighborhood Hits	117
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GCC2_MOUSE
NC score	0.059702 (rank : 469)	θ value	6.88961 (rank : 340)
Query Neighborhood Hits	376	Target Neighborhood Hits	1619	Shared Neighborhood Hits	126
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

DESP_HUMAN
NC score	0.059664 (rank : 470)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	376	Target Neighborhood Hits	1470	Shared Neighborhood Hits	130
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

LUZP1_MOUSE
NC score	0.059585 (rank : 471)	θ value	6.88961 (rank : 345)
Query Neighborhood Hits	376	Target Neighborhood Hits	940	Shared Neighborhood Hits	107
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

HOOK1_HUMAN
NC score	0.059579 (rank : 472)	θ value	6.88961 (rank : 342)
Query Neighborhood Hits	376	Target Neighborhood Hits	942	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

FES_HUMAN
NC score	0.059520 (rank : 473)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	376	Target Neighborhood Hits	978	Shared Neighborhood Hits	70
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

RAD50_HUMAN
NC score	0.059371 (rank : 474)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	376	Target Neighborhood Hits	1317	Shared Neighborhood Hits	118
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

ILK_MOUSE
NC score	0.059296 (rank : 475)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	376	Target Neighborhood Hits	858	Shared Neighborhood Hits	55
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

MYO5C_HUMAN
NC score	0.059245 (rank : 476)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	376	Target Neighborhood Hits	1206	Shared Neighborhood Hits	118
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

CENPE_HUMAN
NC score	0.059220 (rank : 477)	θ value	0.813845 (rank : 258)
Query Neighborhood Hits	376	Target Neighborhood Hits	2060	Shared Neighborhood Hits	147
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

RFIP3_HUMAN
NC score	0.059188 (rank : 478)	θ value	6.88961 (rank : 354)
Query Neighborhood Hits	376	Target Neighborhood Hits	1055	Shared Neighborhood Hits	110
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

MYH4_HUMAN
NC score	0.059188 (rank : 479)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	376	Target Neighborhood Hits	1377	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

ILK1_HUMAN
NC score	0.059129 (rank : 480)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	376	Target Neighborhood Hits	857	Shared Neighborhood Hits	55
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

DMD_MOUSE
NC score	0.059076 (rank : 481)	θ value	4.03905 (rank : 309)
Query Neighborhood Hits	376	Target Neighborhood Hits	1111	Shared Neighborhood Hits	111
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

CN145_HUMAN
NC score	0.058963 (rank : 482)	θ value	3.0926 (rank : 299)
Query Neighborhood Hits	376	Target Neighborhood Hits	1196	Shared Neighborhood Hits	114
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

HMMR_HUMAN
NC score	0.058946 (rank : 483)	θ value	6.88961 (rank : 341)
Query Neighborhood Hits	376	Target Neighborhood Hits	1082	Shared Neighborhood Hits	116
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

GCC2_HUMAN
NC score	0.058788 (rank : 484)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	376	Target Neighborhood Hits	1558	Shared Neighborhood Hits	132
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
NC score	0.058719 (rank : 485)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	376	Target Neighborhood Hits	1559	Shared Neighborhood Hits	131
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

AKAP9_HUMAN
NC score	0.058647 (rank : 486)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	376	Target Neighborhood Hits	1710	Shared Neighborhood Hits	132
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

DMD_HUMAN
NC score	0.058647 (rank : 487)	θ value	3.0926 (rank : 300)
Query Neighborhood Hits	376	Target Neighborhood Hits	1135	Shared Neighborhood Hits	117
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

MRCKB_MOUSE
NC score	0.058627 (rank : 488)	θ value	4.03905 (rank : 313)
Query Neighborhood Hits	376	Target Neighborhood Hits	2180	Shared Neighborhood Hits	165
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

BLNK_MOUSE
NC score	0.058618 (rank : 489)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	376	Target Neighborhood Hits	296	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

MYH14_MOUSE
NC score	0.058542 (rank : 490)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	376	Target Neighborhood Hits	1225	Shared Neighborhood Hits	118
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MY18B_HUMAN
NC score	0.058379 (rank : 491)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	376	Target Neighborhood Hits	1299	Shared Neighborhood Hits	118
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

KMHN1_HUMAN
NC score	0.058317 (rank : 492)	θ value	1.38821 (rank : 281)
Query Neighborhood Hits	376	Target Neighborhood Hits	950	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

RHG12_MOUSE
NC score	0.058316 (rank : 493)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	376	Target Neighborhood Hits	204	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

ILK2_HUMAN
NC score	0.058240 (rank : 494)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	376	Target Neighborhood Hits	848	Shared Neighborhood Hits	55
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ERC2_MOUSE
NC score	0.058173 (rank : 495)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	376	Target Neighborhood Hits	1166	Shared Neighborhood Hits	120
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

CK5P2_HUMAN
NC score	0.058158 (rank : 496)	θ value	4.03905 (rank : 307)
Query Neighborhood Hits	376	Target Neighborhood Hits	1433	Shared Neighborhood Hits	127
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

SMC2_HUMAN
NC score	0.058132 (rank : 497)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	376	Target Neighborhood Hits	1405	Shared Neighborhood Hits	124
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

REPS1_MOUSE
NC score	0.058088 (rank : 498)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	376	Target Neighborhood Hits	204	Shared Neighborhood Hits	18
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

CCD91_MOUSE
NC score	0.058038 (rank : 499)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	376	Target Neighborhood Hits	699	Shared Neighborhood Hits	91
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CYTSA_MOUSE
NC score	0.058022 (rank : 500)	θ value	5.27518 (rank : 321)
Query Neighborhood Hits	376	Target Neighborhood Hits	1104	Shared Neighborhood Hits	113
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

IFT81_MOUSE
NC score	0.057901 (rank : 501)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	376	Target Neighborhood Hits	959	Shared Neighborhood Hits	104
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CI039_HUMAN
NC score	0.057862 (rank : 502)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	376	Target Neighborhood Hits	1171	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

REPS1_HUMAN
NC score	0.057686 (rank : 503)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	376	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

MYH14_HUMAN
NC score	0.057663 (rank : 504)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	376	Target Neighborhood Hits	995	Shared Neighborhood Hits	109
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MIA_HUMAN
NC score	0.057662 (rank : 505)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	376	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

IFT74_HUMAN
NC score	0.057489 (rank : 506)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	376	Target Neighborhood Hits	949	Shared Neighborhood Hits	98
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

CP135_MOUSE
NC score	0.057400 (rank : 507)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	376	Target Neighborhood Hits	1278	Shared Neighborhood Hits	118
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

DLG2_MOUSE
NC score	0.057362 (rank : 508)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	376	Target Neighborhood Hits	271	Shared Neighborhood Hits	73
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

BPAEA_MOUSE
NC score	0.057348 (rank : 509)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	376	Target Neighborhood Hits	1480	Shared Neighborhood Hits	124
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

TAXB1_HUMAN
NC score	0.057191 (rank : 510)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	376	Target Neighborhood Hits	829	Shared Neighborhood Hits	98
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

CP135_HUMAN
NC score	0.057149 (rank : 511)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	376	Target Neighborhood Hits	1290	Shared Neighborhood Hits	113
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

DLG2_HUMAN
NC score	0.057107 (rank : 512)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	376	Target Neighborhood Hits	279	Shared Neighborhood Hits	74
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

AZI1_MOUSE
NC score	0.057070 (rank : 513)	θ value	4.03905 (rank : 305)
Query Neighborhood Hits	376	Target Neighborhood Hits	990	Shared Neighborhood Hits	113
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

PLCB2_HUMAN
NC score	0.057070 (rank : 514)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	376	Target Neighborhood Hits	608	Shared Neighborhood Hits	88
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

CCD13_HUMAN
NC score	0.057050 (rank : 515)	θ value	5.27518 (rank : 318)
Query Neighborhood Hits	376	Target Neighborhood Hits	721	Shared Neighborhood Hits	94
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

K0555_HUMAN
NC score	0.057023 (rank : 516)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	376	Target Neighborhood Hits	880	Shared Neighborhood Hits	107
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

STYK1_MOUSE
NC score	0.056998 (rank : 517)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	376	Target Neighborhood Hits	779	Shared Neighborhood Hits	42
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

STYK1_HUMAN
NC score	0.056887 (rank : 518)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	376	Target Neighborhood Hits	786	Shared Neighborhood Hits	42
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

RUFY1_HUMAN
NC score	0.056877 (rank : 519)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	376	Target Neighborhood Hits	848	Shared Neighborhood Hits	108
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

FES_MOUSE
NC score	0.056858 (rank : 520)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	376	Target Neighborhood Hits	980	Shared Neighborhood Hits	77
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

CCD41_HUMAN
NC score	0.056739 (rank : 521)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	376	Target Neighborhood Hits	1139	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

ROCK2_MOUSE
NC score	0.056653 (rank : 522)	θ value	0.125558 (rank : 206)
Query Neighborhood Hits	376	Target Neighborhood Hits	2072	Shared Neighborhood Hits	152
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

BPA1_MOUSE
NC score	0.056606 (rank : 523)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	376	Target Neighborhood Hits	1477	Shared Neighborhood Hits	119
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

IFT74_MOUSE
NC score	0.056591 (rank : 524)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	376	Target Neighborhood Hits	939	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

GOGA5_MOUSE
NC score	0.056578 (rank : 525)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	376	Target Neighborhood Hits	1434	Shared Neighborhood Hits	126
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

MYO10_HUMAN
NC score	0.056514 (rank : 526)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	376	Target Neighborhood Hits	920	Shared Neighborhood Hits	107
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

HGS_MOUSE
NC score	0.056504 (rank : 527)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	376	Target Neighborhood Hits	589	Shared Neighborhood Hits	48
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

TNK1_MOUSE
NC score	0.056382 (rank : 528)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	376	Target Neighborhood Hits	806	Shared Neighborhood Hits	48
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

DLG3_HUMAN
NC score	0.056370 (rank : 529)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	376	Target Neighborhood Hits	269	Shared Neighborhood Hits	72
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

GOGA1_HUMAN
NC score	0.056358 (rank : 530)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	376	Target Neighborhood Hits	1222	Shared Neighborhood Hits	116
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

SYNE2_HUMAN
NC score	0.056349 (rank : 531)	θ value	5.27518 (rank : 334)
Query Neighborhood Hits	376	Target Neighborhood Hits	1323	Shared Neighborhood Hits	119
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

HOOK2_MOUSE
NC score	0.056282 (rank : 532)	θ value	1.38821 (rank : 280)
Query Neighborhood Hits	376	Target Neighborhood Hits	736	Shared Neighborhood Hits	100
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

RHG12_HUMAN
NC score	0.056253 (rank : 533)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	376	Target Neighborhood Hits	190	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

REST_HUMAN
NC score	0.056249 (rank : 534)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	376	Target Neighborhood Hits	1605	Shared Neighborhood Hits	127
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SYCP1_HUMAN
NC score	0.056240 (rank : 535)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	376	Target Neighborhood Hits	1313	Shared Neighborhood Hits	117
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

MRCKB_HUMAN
NC score	0.056192 (rank : 536)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	376	Target Neighborhood Hits	2239	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

CT2NL_HUMAN
NC score	0.056049 (rank : 537)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	376	Target Neighborhood Hits	1059	Shared Neighborhood Hits	109
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

DLG3_MOUSE
NC score	0.055965 (rank : 538)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	376	Target Neighborhood Hits	274	Shared Neighborhood Hits	72
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

RHG09_HUMAN
NC score	0.055915 (rank : 539)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	376	Target Neighborhood Hits	186	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

HGS_HUMAN
NC score	0.055893 (rank : 540)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	376	Target Neighborhood Hits	517	Shared Neighborhood Hits	42
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

GAS8_HUMAN
NC score	0.055836 (rank : 541)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	376	Target Neighborhood Hits	819	Shared Neighborhood Hits	98
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

MACF1_HUMAN
NC score	0.055800 (rank : 542)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	376	Target Neighborhood Hits	1341	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

HOOK1_MOUSE
NC score	0.055777 (rank : 543)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	376	Target Neighborhood Hits	910	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

TAXB1_MOUSE
NC score	0.055771 (rank : 544)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	376	Target Neighborhood Hits	886	Shared Neighborhood Hits	106
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

CF060_HUMAN
NC score	0.055767 (rank : 545)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	376	Target Neighborhood Hits	1270	Shared Neighborhood Hits	112
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

RFIP4_HUMAN
NC score	0.055713 (rank : 546)	θ value	4.03905 (rank : 314)
Query Neighborhood Hits	376	Target Neighborhood Hits	785	Shared Neighborhood Hits	94
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

INCE_MOUSE
NC score	0.055685 (rank : 547)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	376	Target Neighborhood Hits	903	Shared Neighborhood Hits	110
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

ERC2_HUMAN
NC score	0.055648 (rank : 548)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	376	Target Neighborhood Hits	1156	Shared Neighborhood Hits	118
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

PEPL_HUMAN
NC score	0.055562 (rank : 549)	θ value	2.36792 (rank : 293)
Query Neighborhood Hits	376	Target Neighborhood Hits	1141	Shared Neighborhood Hits	113
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

SOCS2_MOUSE
NC score	0.055416 (rank : 550)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	376	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SDCG8_HUMAN
NC score	0.055415 (rank : 551)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	376	Target Neighborhood Hits	1002	Shared Neighborhood Hits	102
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

REST_MOUSE
NC score	0.055318 (rank : 552)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	376	Target Neighborhood Hits	1506	Shared Neighborhood Hits	122
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

KTN1_MOUSE
NC score	0.055211 (rank : 553)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	376	Target Neighborhood Hits	1324	Shared Neighborhood Hits	120
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

MIA_MOUSE
NC score	0.055088 (rank : 554)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	376	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

PLCB1_HUMAN
NC score	0.054905 (rank : 555)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	376	Target Neighborhood Hits	614	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

KMHN1_MOUSE
NC score	0.054860 (rank : 556)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	376	Target Neighborhood Hits	949	Shared Neighborhood Hits	106
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

RUFY2_MOUSE
NC score	0.054806 (rank : 557)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	376	Target Neighborhood Hits	820	Shared Neighborhood Hits	103
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

TRHY_HUMAN
NC score	0.054732 (rank : 558)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	376	Target Neighborhood Hits	1385	Shared Neighborhood Hits	122
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

TPR_HUMAN
NC score	0.054715 (rank : 559)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	376	Target Neighborhood Hits	1921	Shared Neighborhood Hits	134
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

FYCO1_MOUSE
NC score	0.054668 (rank : 560)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	376	Target Neighborhood Hits	1059	Shared Neighborhood Hits	112
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

TNK1_HUMAN
NC score	0.054571 (rank : 561)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	376	Target Neighborhood Hits	815	Shared Neighborhood Hits	48
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

CCD19_HUMAN
NC score	0.054553 (rank : 562)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	376	Target Neighborhood Hits	639	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CCD21_MOUSE
NC score	0.054534 (rank : 563)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	376	Target Neighborhood Hits	1135	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

DLG5_HUMAN
NC score	0.054476 (rank : 564)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	376	Target Neighborhood Hits	1088	Shared Neighborhood Hits	145
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ROCK2_HUMAN
NC score	0.054414 (rank : 565)	θ value	0.279714 (rank : 229)
Query Neighborhood Hits	376	Target Neighborhood Hits	2073	Shared Neighborhood Hits	155
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

CYTSA_HUMAN
NC score	0.054407 (rank : 566)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	376	Target Neighborhood Hits	1138	Shared Neighborhood Hits	118
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

INCE_HUMAN
NC score	0.054223 (rank : 567)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	376	Target Neighborhood Hits	978	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

GOGA1_MOUSE
NC score	0.054090 (rank : 568)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	376	Target Neighborhood Hits	994	Shared Neighborhood Hits	108
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

MOES_MOUSE
NC score	0.054027 (rank : 569)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	376	Target Neighborhood Hits	923	Shared Neighborhood Hits	106
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

DLG1_HUMAN
NC score	0.053992 (rank : 570)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	376	Target Neighborhood Hits	290	Shared Neighborhood Hits	70
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

GOGA5_HUMAN
NC score	0.053941 (rank : 571)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	376	Target Neighborhood Hits	1168	Shared Neighborhood Hits	110
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

GOGA3_HUMAN
NC score	0.053927 (rank : 572)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	376	Target Neighborhood Hits	1317	Shared Neighborhood Hits	120
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

BLNK_HUMAN
NC score	0.053842 (rank : 573)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	376	Target Neighborhood Hits	228	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

SAS6_MOUSE
NC score	0.053739 (rank : 574)	θ value	5.27518 (rank : 331)
Query Neighborhood Hits	376	Target Neighborhood Hits	931	Shared Neighborhood Hits	99
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

LTK_HUMAN
NC score	0.053730 (rank : 575)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	376	Target Neighborhood Hits	774	Shared Neighborhood Hits	42
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

MOES_HUMAN
NC score	0.053713 (rank : 576)	θ value	8.99809 (rank : 366)
Query Neighborhood Hits	376	Target Neighborhood Hits	892	Shared Neighborhood Hits	102
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

CARD9_HUMAN
NC score	0.053712 (rank : 577)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	376	Target Neighborhood Hits	602	Shared Neighborhood Hits	91
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

OPTN_MOUSE
NC score	0.053683 (rank : 578)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	376	Target Neighborhood Hits	1120	Shared Neighborhood Hits	108
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

MD1L1_MOUSE
NC score	0.053602 (rank : 579)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	376	Target Neighborhood Hits	1001	Shared Neighborhood Hits	102
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

CK5P2_MOUSE
NC score	0.053488 (rank : 580)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	376	Target Neighborhood Hits	1151	Shared Neighborhood Hits	111
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CTRO_MOUSE
NC score	0.053357 (rank : 581)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	376	Target Neighborhood Hits	2344	Shared Neighborhood Hits	167
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

PCNT_MOUSE
NC score	0.053336 (rank : 582)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	376	Target Neighborhood Hits	1207	Shared Neighborhood Hits	114
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

MYO5A_HUMAN
NC score	0.053313 (rank : 583)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	376	Target Neighborhood Hits	1092	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

ROCK1_MOUSE
NC score	0.053219 (rank : 584)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	376	Target Neighborhood Hits	2126	Shared Neighborhood Hits	154
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RB6I2_MOUSE
NC score	0.053215 (rank : 585)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	376	Target Neighborhood Hits	1433	Shared Neighborhood Hits	116
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

FAK2_HUMAN
NC score	0.053180 (rank : 586)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	376	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
NC score	0.053158 (rank : 587)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	376	Target Neighborhood Hits	851	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

RUFY1_MOUSE
NC score	0.053156 (rank : 588)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	376	Target Neighborhood Hits	765	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

LTK_MOUSE
NC score	0.053153 (rank : 589)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	376	Target Neighborhood Hits	770	Shared Neighborhood Hits	43
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ROS_HUMAN
NC score	0.053137 (rank : 590)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	376	Target Neighborhood Hits	907	Shared Neighborhood Hits	45
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

NIN_HUMAN
NC score	0.053099 (rank : 591)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	376	Target Neighborhood Hits	1416	Shared Neighborhood Hits	121
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

CCD21_HUMAN
NC score	0.052969 (rank : 592)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	376	Target Neighborhood Hits	1228	Shared Neighborhood Hits	118
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

OPTN_HUMAN
NC score	0.052944 (rank : 593)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	376	Target Neighborhood Hits	827	Shared Neighborhood Hits	99
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

MYO6_HUMAN
NC score	0.052891 (rank : 594)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	376	Target Neighborhood Hits	727	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

GOGA6_HUMAN
NC score	0.052873 (rank : 595)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	376	Target Neighborhood Hits	1007	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

CYLN2_HUMAN
NC score	0.052822 (rank : 596)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	376	Target Neighborhood Hits	1004	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

TUFT1_HUMAN
NC score	0.052820 (rank : 597)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	376	Target Neighborhood Hits	686	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

CNTRB_MOUSE
NC score	0.052779 (rank : 598)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	376	Target Neighborhood Hits	1029	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

RB6I2_HUMAN
NC score	0.052754 (rank : 599)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	376	Target Neighborhood Hits	1584	Shared Neighborhood Hits	120
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

CCD96_MOUSE
NC score	0.052740 (rank : 600)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	376	Target Neighborhood Hits	704	Shared Neighborhood Hits	82
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

MRCKA_HUMAN
NC score	0.052733 (rank : 601)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	376	Target Neighborhood Hits	1999	Shared Neighborhood Hits	155
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

INVO_HUMAN
NC score	0.052714 (rank : 602)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	376	Target Neighborhood Hits	636	Shared Neighborhood Hits	84
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

CING_MOUSE
NC score	0.052704 (rank : 603)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	376	Target Neighborhood Hits	1432	Shared Neighborhood Hits	124
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

RYK_HUMAN
NC score	0.052676 (rank : 604)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	376	Target Neighborhood Hits	701	Shared Neighborhood Hits	36
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

CCD39_MOUSE
NC score	0.052616 (rank : 605)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	376	Target Neighborhood Hits	1026	Shared Neighborhood Hits	101
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

PLCB3_HUMAN
NC score	0.052592 (rank : 606)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	376	Target Neighborhood Hits	445	Shared Neighborhood Hits	70
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

HOOK2_HUMAN
NC score	0.052478 (rank : 607)	θ value	3.0926 (rank : 301)
Query Neighborhood Hits	376	Target Neighborhood Hits	714	Shared Neighborhood Hits	92
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

CJ118_MOUSE
NC score	0.052473 (rank : 608)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	376	Target Neighborhood Hits	1132	Shared Neighborhood Hits	110
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

ANR26_HUMAN
NC score	0.052454 (rank : 609)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	376	Target Neighborhood Hits	1614	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ALK_MOUSE
NC score	0.052451 (rank : 610)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	376	Target Neighborhood Hits	811	Shared Neighborhood Hits	47
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

RADI_HUMAN
NC score	0.052449 (rank : 611)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	376	Target Neighborhood Hits	741	Shared Neighborhood Hits	102
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

EPHB6_HUMAN
NC score	0.052440 (rank : 612)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	376	Target Neighborhood Hits	912	Shared Neighborhood Hits	47
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

STK10_MOUSE
NC score	0.052381 (rank : 613)	θ value	6.88961 (rank : 355)
Query Neighborhood Hits	376	Target Neighborhood Hits	2132	Shared Neighborhood Hits	147
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

PLCB1_MOUSE
NC score	0.052368 (rank : 614)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	376	Target Neighborhood Hits	531	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

IFT81_HUMAN
NC score	0.052306 (rank : 615)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	376	Target Neighborhood Hits	893	Shared Neighborhood Hits	101
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

FYCO1_HUMAN
NC score	0.052252 (rank : 616)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	376	Target Neighborhood Hits	1149	Shared Neighborhood Hits	112
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

CING_HUMAN
NC score	0.052239 (rank : 617)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	376	Target Neighborhood Hits	1275	Shared Neighborhood Hits	120
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CYLN2_MOUSE
NC score	0.052213 (rank : 618)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	376	Target Neighborhood Hits	1002	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

ALK_HUMAN
NC score	0.052177 (rank : 619)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	376	Target Neighborhood Hits	795	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

RYK_MOUSE
NC score	0.052063 (rank : 620)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	376	Target Neighborhood Hits	715	Shared Neighborhood Hits	36
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

RABE1_HUMAN
NC score	0.052027 (rank : 621)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	376	Target Neighborhood Hits	1104	Shared Neighborhood Hits	112
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

XE7_HUMAN
NC score	0.052011 (rank : 622)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	376	Target Neighborhood Hits	738	Shared Neighborhood Hits	95
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

DDR1_MOUSE
NC score	0.051986 (rank : 623)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	376	Target Neighborhood Hits	818	Shared Neighborhood Hits	41
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

EPHB6_MOUSE
NC score	0.051984 (rank : 624)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	376	Target Neighborhood Hits	906	Shared Neighborhood Hits	47
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

RFIP4_MOUSE
NC score	0.051949 (rank : 625)	θ value	4.03905 (rank : 315)
Query Neighborhood Hits	376	Target Neighborhood Hits	708	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

GOGA2_MOUSE
NC score	0.051940 (rank : 626)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	376	Target Neighborhood Hits	944	Shared Neighborhood Hits	111
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

SOCS2_HUMAN
NC score	0.051728 (rank : 627)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	376	Target Neighborhood Hits	104	Shared Neighborhood Hits	32
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

ERBB4_HUMAN
NC score	0.051695 (rank : 628)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	376	Target Neighborhood Hits	910	Shared Neighborhood Hits	46
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

BICD2_HUMAN
NC score	0.051683 (rank : 629)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	376	Target Neighborhood Hits	856	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

MYO6_MOUSE
NC score	0.051592 (rank : 630)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	376	Target Neighborhood Hits	586	Shared Neighborhood Hits	81
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

IF3A_MOUSE
NC score	0.051579 (rank : 631)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	376	Target Neighborhood Hits	871	Shared Neighborhood Hits	103
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

CASP_MOUSE
NC score	0.051566 (rank : 632)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	376	Target Neighborhood Hits	1152	Shared Neighborhood Hits	118
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

ROCK1_HUMAN
NC score	0.051509 (rank : 633)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	376	Target Neighborhood Hits	2000	Shared Neighborhood Hits	152
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

CASP_HUMAN
NC score	0.051420 (rank : 634)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	376	Target Neighborhood Hits	1131	Shared Neighborhood Hits	115
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

TMF1_HUMAN
NC score	0.051291 (rank : 635)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	376	Target Neighborhood Hits	987	Shared Neighborhood Hits	104
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

EPHAA_HUMAN
NC score	0.051252 (rank : 636)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	376	Target Neighborhood Hits	960	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

DDR1_HUMAN
NC score	0.051169 (rank : 637)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	376	Target Neighborhood Hits	819	Shared Neighborhood Hits	41
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

IGF1R_MOUSE
NC score	0.051145 (rank : 638)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	376	Target Neighborhood Hits	973	Shared Neighborhood Hits	43
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

MYO5A_MOUSE
NC score	0.051124 (rank : 639)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	376	Target Neighborhood Hits	1117	Shared Neighborhood Hits	109
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

DLG1_MOUSE
NC score	0.051040 (rank : 640)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	376	Target Neighborhood Hits	285	Shared Neighborhood Hits	66
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

ROR2_MOUSE
NC score	0.051038 (rank : 641)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	376	Target Neighborhood Hits	1000	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

IGF1R_HUMAN
NC score	0.051003 (rank : 642)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	376	Target Neighborhood Hits	977	Shared Neighborhood Hits	44
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

DLG4_HUMAN
NC score	0.051003 (rank : 643)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	376	Target Neighborhood Hits	286	Shared Neighborhood Hits	71
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

CROCC_HUMAN
NC score	0.050934 (rank : 644)	θ value	4.03905 (rank : 308)
Query Neighborhood Hits	376	Target Neighborhood Hits	1409	Shared Neighborhood Hits	117
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

EPHA1_HUMAN
NC score	0.050863 (rank : 645)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	376	Target Neighborhood Hits	997	Shared Neighborhood Hits	49
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

FAK1_HUMAN
NC score	0.050838 (rank : 646)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	376	Target Neighborhood Hits	850	Shared Neighborhood Hits	43
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

CCD39_HUMAN
NC score	0.050831 (rank : 647)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	376	Target Neighborhood Hits	868	Shared Neighborhood Hits	98
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CF182_HUMAN
NC score	0.050756 (rank : 648)	θ value	5.27518 (rank : 320)
Query Neighborhood Hits	376	Target Neighborhood Hits	474	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

ERBB2_HUMAN
NC score	0.050741 (rank : 649)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	376	Target Neighborhood Hits	1073	Shared Neighborhood Hits	47
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
NC score	0.050697 (rank : 650)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	376	Target Neighborhood Hits	918	Shared Neighborhood Hits	44
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

FAK1_MOUSE
NC score	0.050693 (rank : 651)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	376	Target Neighborhood Hits	850	Shared Neighborhood Hits	42
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

ROR2_HUMAN
NC score	0.050644 (rank : 652)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	376	Target Neighborhood Hits	1014	Shared Neighborhood Hits	42
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ANR26_MOUSE
NC score	0.050633 (rank : 653)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	376	Target Neighborhood Hits	1554	Shared Neighborhood Hits	120
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

RON_MOUSE
NC score	0.050608 (rank : 654)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	376	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

MYO5B_HUMAN
NC score	0.050580 (rank : 655)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	376	Target Neighborhood Hits	911	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

SPTN5_HUMAN
NC score	0.050579 (rank : 656)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	376	Target Neighborhood Hits	674	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

KTN1_HUMAN
NC score	0.050578 (rank : 657)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	376	Target Neighborhood Hits	1197	Shared Neighborhood Hits	111
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

BRE1B_HUMAN
NC score	0.050560 (rank : 658)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	376	Target Neighborhood Hits	1040	Shared Neighborhood Hits	103
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

AATK_MOUSE
NC score	0.050542 (rank : 659)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	376	Target Neighborhood Hits	942	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

FLT3_MOUSE
NC score	0.050427 (rank : 660)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	376	Target Neighborhood Hits	847	Shared Neighborhood Hits	41
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

RON_HUMAN
NC score	0.050420 (rank : 661)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	376	Target Neighborhood Hits	842	Shared Neighborhood Hits	43
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

EPHA1_MOUSE
NC score	0.050335 (rank : 662)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	376	Target Neighborhood Hits	958	Shared Neighborhood Hits	49
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

FLT3_HUMAN
NC score	0.050292 (rank : 663)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	376	Target Neighborhood Hits	843	Shared Neighborhood Hits	42
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

RBCC1_MOUSE
NC score	0.050194 (rank : 664)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	376	Target Neighborhood Hits	1048	Shared Neighborhood Hits	105
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RADI_MOUSE
NC score	0.050123 (rank : 665)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	376	Target Neighborhood Hits	773	Shared Neighborhood Hits	96
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

DDR2_HUMAN
NC score	0.050091 (rank : 666)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	376	Target Neighborhood Hits	818	Shared Neighborhood Hits	44
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

MPP3_HUMAN
NC score	0.050035 (rank : 667)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	376	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

STIM1_HUMAN
NC score	0.049616 (rank : 668)	θ value	5.27518 (rank : 332)
Query Neighborhood Hits	376	Target Neighborhood Hits	665	Shared Neighborhood Hits	91
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

IF2P_HUMAN
NC score	0.049498 (rank : 669)	θ value	4.03905 (rank : 311)
Query Neighborhood Hits	376	Target Neighborhood Hits	889	Shared Neighborhood Hits	100
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

UACA_MOUSE
NC score	0.048327 (rank : 670)	θ value	8.99809 (rank : 376)
Query Neighborhood Hits	376	Target Neighborhood Hits	1620	Shared Neighborhood Hits	130
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

BICD1_MOUSE
NC score	0.048117 (rank : 671)	θ value	8.99809 (rank : 357)
Query Neighborhood Hits	376	Target Neighborhood Hits	837	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

STIM1_MOUSE
NC score	0.047619 (rank : 672)	θ value	5.27518 (rank : 333)
Query Neighborhood Hits	376	Target Neighborhood Hits	660	Shared Neighborhood Hits	90
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

SLK_HUMAN
NC score	0.046221 (rank : 673)	θ value	2.36792 (rank : 297)
Query Neighborhood Hits	376	Target Neighborhood Hits	1775	Shared Neighborhood Hits	139
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

NEST_HUMAN
NC score	0.045602 (rank : 674)	θ value	8.99809 (rank : 373)
Query Neighborhood Hits	376	Target Neighborhood Hits	1305	Shared Neighborhood Hits	101
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

ANR18_HUMAN
NC score	0.044998 (rank : 675)	θ value	0.47712 (rank : 242)
Query Neighborhood Hits	376	Target Neighborhood Hits	1106	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

MPP9_HUMAN
NC score	0.043814 (rank : 676)	θ value	5.27518 (rank : 324)
Query Neighborhood Hits	376	Target Neighborhood Hits	529	Shared Neighborhood Hits	79
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

REN3A_HUMAN
NC score	0.039927 (rank : 677)	θ value	2.36792 (rank : 295)
Query Neighborhood Hits	376	Target Neighborhood Hits	248	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H1J1, Q5T8C3, Q5T8C9, Q7Z6N3, Q86YK1, Q9BZI8	Gene names	UPF3A, RENT3A, UPF3
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3).

RNF8_MOUSE
NC score	0.037884 (rank : 678)	θ value	0.163984 (rank : 215)
Query Neighborhood Hits	376	Target Neighborhood Hits	618	Shared Neighborhood Hits	71
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

ALO17_HUMAN
NC score	0.037174 (rank : 679)	θ value	0.47712 (rank : 241)
Query Neighborhood Hits	376	Target Neighborhood Hits	317	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCF4, Q69YK7, Q8IWF4, Q8IZX1, Q8IZX2, Q8N406	Gene names	KIAA1618, ALO17
Domain Architecture	No domain graphic available
Description	Protein ALO17 (ALK lymphoma oligomerization partner on chromosome 17).

LIN9_HUMAN
NC score	0.034285 (rank : 680)	θ value	0.47712 (rank : 247)
Query Neighborhood Hits	376	Target Neighborhood Hits	35	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TKA1, Q5U5L8, Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1	Gene names	LIN9, BARA, TGS
Domain Architecture	No domain graphic available
Description	Lin-9 homolog (huLin-9) (hLin-9) (Beta-subunit associated regulator of apoptosis) (Type I interferon receptor beta chain-associated protein) (TUDOR gene similar protein) (pRB-associated protein).

CAR14_HUMAN
NC score	0.032650 (rank : 681)	θ value	3.0926 (rank : 298)
Query Neighborhood Hits	376	Target Neighborhood Hits	449	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

LAMA2_MOUSE
NC score	0.032592 (rank : 682)	θ value	0.813845 (rank : 262)
Query Neighborhood Hits	376	Target Neighborhood Hits	1198	Shared Neighborhood Hits	94
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LIN9_MOUSE
NC score	0.031877 (rank : 683)	θ value	1.06291 (rank : 273)
Query Neighborhood Hits	376	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C735, Q5TKA0, Q8C9D8	Gene names	Lin9, Bara, Tgs1
Domain Architecture	No domain graphic available
Description	Lin-9 homolog (mLin-9) (Type I interferon receptor beta chain- associated protein) (TUDOR gene similar 1 protein).

CSKI1_HUMAN
NC score	0.029882 (rank : 684)	θ value	8.99809 (rank : 360)
Query Neighborhood Hits	376	Target Neighborhood Hits	997	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

RF1M_HUMAN
NC score	0.029653 (rank : 685)	θ value	2.36792 (rank : 296)
Query Neighborhood Hits	376	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	O75570, Q5T6Y5, Q8IUQ6	Gene names	MTRF1
Domain Architecture
Description	Peptide chain release factor 1, mitochondrial precursor (MRF-1).

CD2L5_HUMAN
NC score	0.028554 (rank : 686)	θ value	8.99809 (rank : 358)
Query Neighborhood Hits	376	Target Neighborhood Hits	987	Shared Neighborhood Hits	46
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

NFM_HUMAN
NC score	0.026982 (rank : 687)	θ value	6.88961 (rank : 349)
Query Neighborhood Hits	376	Target Neighborhood Hits	1328	Shared Neighborhood Hits	111
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NFM_MOUSE
NC score	0.026549 (rank : 688)	θ value	6.88961 (rank : 350)
Query Neighborhood Hits	376	Target Neighborhood Hits	1159	Shared Neighborhood Hits	108
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

KIF11_HUMAN
NC score	0.024465 (rank : 689)	θ value	5.27518 (rank : 323)
Query Neighborhood Hits	376	Target Neighborhood Hits	583	Shared Neighborhood Hits	88
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

AMPE_HUMAN
NC score	0.023933 (rank : 690)	θ value	0.62314 (rank : 252)
Query Neighborhood Hits	376	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

NCOR2_MOUSE
NC score	0.023669 (rank : 691)	θ value	8.99809 (rank : 372)
Query Neighborhood Hits	376	Target Neighborhood Hits	790	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

CM007_HUMAN
NC score	0.019790 (rank : 692)	θ value	8.99809 (rank : 359)
Query Neighborhood Hits	376	Target Neighborhood Hits	422	Shared Neighborhood Hits	58
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

CDT1_MOUSE
NC score	0.015736 (rank : 693)	θ value	4.03905 (rank : 306)
Query Neighborhood Hits	376	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

LAMB1_MOUSE
NC score	0.014643 (rank : 694)	θ value	6.88961 (rank : 344)
Query Neighborhood Hits	376	Target Neighborhood Hits	919	Shared Neighborhood Hits	82
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

NCOR1_MOUSE
NC score	0.013388 (rank : 695)	θ value	8.99809 (rank : 371)
Query Neighborhood Hits	376	Target Neighborhood Hits	521	Shared Neighborhood Hits	40
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

LAMA5_HUMAN
NC score	0.012372 (rank : 696)	θ value	0.279714 (rank : 227)
Query Neighborhood Hits	376	Target Neighborhood Hits	976	Shared Neighborhood Hits	62
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

NOC2L_MOUSE
NC score	0.011934 (rank : 697)	θ value	5.27518 (rank : 330)
Query Neighborhood Hits	376	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WV70, Q8VE16	Gene names	Noc2l
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

HCN3_HUMAN
NC score	0.011734 (rank : 698)	θ value	0.365318 (rank : 236)
Query Neighborhood Hits	376	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

AMPE_MOUSE
NC score	0.010100 (rank : 699)	θ value	5.27518 (rank : 317)
Query Neighborhood Hits	376	Target Neighborhood Hits	35	Shared Neighborhood Hits	7
SwissProt Accessions	P16406	Gene names	Enpep
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (BP-1/6C3 antigen).

PO121_MOUSE
NC score	0.009832 (rank : 700)	θ value	8.99809 (rank : 375)
Query Neighborhood Hits	376	Target Neighborhood Hits	345	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

HXK4_HUMAN
NC score	0.008808 (rank : 701)	θ value	1.81305 (rank : 283)
Query Neighborhood Hits	376	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P35557, Q05810	Gene names	GCK
Domain Architecture
Description	Glucokinase (EC 2.7.1.2) (Hexokinase-4) (Hexokinase type IV) (HK IV) (HK4) (Hexokinase-D).

TRI16_HUMAN
NC score	0.008220 (rank : 702)	θ value	6.88961 (rank : 356)
Query Neighborhood Hits	376	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

MYST4_MOUSE
NC score	0.007869 (rank : 703)	θ value	6.88961 (rank : 348)
Query Neighborhood Hits	376	Target Neighborhood Hits	416	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

K1802_MOUSE
NC score	0.007435 (rank : 704)	θ value	2.36792 (rank : 290)
Query Neighborhood Hits	376	Target Neighborhood Hits	1596	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

GORS2_MOUSE
NC score	0.006297 (rank : 705)	θ value	8.99809 (rank : 364)
Query Neighborhood Hits	376	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

DDX49_HUMAN
NC score	0.004154 (rank : 706)	θ value	5.27518 (rank : 322)
Query Neighborhood Hits	376	Target Neighborhood Hits	223	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

HTF4_HUMAN
NC score	0.003782 (rank : 707)	θ value	8.99809 (rank : 365)
Query Neighborhood Hits	376	Target Neighborhood Hits	152	Shared Neighborhood Hits	9
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

DSG1B_MOUSE
NC score	-0.001870 (rank : 708)	θ value	4.03905 (rank : 310)
Query Neighborhood Hits	376	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TSF1, Q7TQ60	Gene names	Dsg1b, Dsg5
Domain Architecture	No domain graphic available
Description	Desmoglein-1 beta precursor (Dsg1-beta) (Desmoglein-5).