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Network neighborhood for query Sequence : REPS2_MOUSE

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REPS2_MOUSE
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

REPS2_HUMAN
θ value	0 (rank : 1)	NC score	0.967026 (rank : 2)
Query Neighborhood Hits	102	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	102	Target Neighborhood Hits	102	Shared Neighborhood Hits	102
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS1_MOUSE
θ value	3.16345e-37 (rank : 3)	NC score	0.805620 (rank : 3)
Query Neighborhood Hits	102	Target Neighborhood Hits	204	Shared Neighborhood Hits	26
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_HUMAN
θ value	1.57e-36 (rank : 4)	NC score	0.797333 (rank : 4)
Query Neighborhood Hits	102	Target Neighborhood Hits	205	Shared Neighborhood Hits	29
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

ITSN1_HUMAN
θ value	8.38298e-14 (rank : 5)	NC score	0.280216 (rank : 19)
Query Neighborhood Hits	102	Target Neighborhood Hits	1757	Shared Neighborhood Hits	46
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	1.58096e-12 (rank : 6)	NC score	0.280509 (rank : 18)
Query Neighborhood Hits	102	Target Neighborhood Hits	1669	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_MOUSE
θ value	3.52202e-12 (rank : 7)	NC score	0.284351 (rank : 17)
Query Neighborhood Hits	102	Target Neighborhood Hits	1371	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN2_HUMAN
θ value	6.00763e-12 (rank : 8)	NC score	0.295800 (rank : 16)
Query Neighborhood Hits	102	Target Neighborhood Hits	1173	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

EHD4_HUMAN
θ value	2.28291e-11 (rank : 9)	NC score	0.535548 (rank : 6)
Query Neighborhood Hits	102	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H223, Q9HAR1, Q9NZN2	Gene names	EHD4, HCA10, HCA11
Domain Architecture
Description	EH-domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11).

EHD4_MOUSE
θ value	2.28291e-11 (rank : 10)	NC score	0.539737 (rank : 5)
Query Neighborhood Hits	102	Target Neighborhood Hits	40	Shared Neighborhood Hits	19
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

EP15_HUMAN
θ value	6.64225e-11 (rank : 11)	NC score	0.375559 (rank : 13)
Query Neighborhood Hits	102	Target Neighborhood Hits	1021	Shared Neighborhood Hits	32
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	6.64225e-11 (rank : 12)	NC score	0.394571 (rank : 12)
Query Neighborhood Hits	102	Target Neighborhood Hits	820	Shared Neighborhood Hits	35
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15R_HUMAN
θ value	1.25267e-09 (rank : 13)	NC score	0.330586 (rank : 15)
Query Neighborhood Hits	102	Target Neighborhood Hits	1083	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EHD2_HUMAN
θ value	2.79066e-09 (rank : 14)	NC score	0.533576 (rank : 7)
Query Neighborhood Hits	102	Target Neighborhood Hits	29	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EP15R_MOUSE
θ value	6.21693e-09 (rank : 15)	NC score	0.336233 (rank : 14)
Query Neighborhood Hits	102	Target Neighborhood Hits	1135	Shared Neighborhood Hits	38
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EHD1_HUMAN
θ value	3.08544e-08 (rank : 16)	NC score	0.524172 (rank : 8)
Query Neighborhood Hits	102	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
θ value	4.0297e-08 (rank : 17)	NC score	0.523569 (rank : 9)
Query Neighborhood Hits	102	Target Neighborhood Hits	37	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EHD3_MOUSE
θ value	8.97725e-08 (rank : 18)	NC score	0.519738 (rank : 10)
Query Neighborhood Hits	102	Target Neighborhood Hits	34	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD3_HUMAN
θ value	4.45536e-07 (rank : 19)	NC score	0.515419 (rank : 11)
Query Neighborhood Hits	102	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

SEPT9_HUMAN
θ value	0.00665767 (rank : 20)	NC score	0.049250 (rank : 126)
Query Neighborhood Hits	102	Target Neighborhood Hits	706	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SHAN2_HUMAN
θ value	0.0193708 (rank : 21)	NC score	0.068221 (rank : 55)
Query Neighborhood Hits	102	Target Neighborhood Hits	346	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

PITM2_HUMAN
θ value	0.0330416 (rank : 22)	NC score	0.046795 (rank : 129)
Query Neighborhood Hits	102	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZ72, Q9P271	Gene names	PITPNM2, KIAA1457, NIR3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3).

TP53B_HUMAN
θ value	0.0330416 (rank : 23)	NC score	0.064963 (rank : 71)
Query Neighborhood Hits	102	Target Neighborhood Hits	413	Shared Neighborhood Hits	13
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

RC3H1_MOUSE
θ value	0.0563607 (rank : 24)	NC score	0.038547 (rank : 142)
Query Neighborhood Hits	102	Target Neighborhood Hits	244	Shared Neighborhood Hits	3
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

CSPG3_HUMAN
θ value	0.0961366 (rank : 25)	NC score	0.021487 (rank : 170)
Query Neighborhood Hits	102	Target Neighborhood Hits	676	Shared Neighborhood Hits	8
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

RGS3_MOUSE
θ value	0.0961366 (rank : 26)	NC score	0.045632 (rank : 130)
Query Neighborhood Hits	102	Target Neighborhood Hits	1621	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

BLNK_MOUSE
θ value	0.21417 (rank : 27)	NC score	0.069005 (rank : 52)
Query Neighborhood Hits	102	Target Neighborhood Hits	296	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

ICK_HUMAN
θ value	0.21417 (rank : 28)	NC score	0.013131 (rank : 179)
Query Neighborhood Hits	102	Target Neighborhood Hits	867	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

GOGA2_MOUSE
θ value	0.279714 (rank : 29)	NC score	0.071235 (rank : 46)
Query Neighborhood Hits	102	Target Neighborhood Hits	944	Shared Neighborhood Hits	27
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

MYT1_HUMAN
θ value	0.279714 (rank : 30)	NC score	0.032020 (rank : 151)
Query Neighborhood Hits	102	Target Neighborhood Hits	475	Shared Neighborhood Hits	10
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

K1543_MOUSE
θ value	0.365318 (rank : 31)	NC score	0.050457 (rank : 120)
Query Neighborhood Hits	102	Target Neighborhood Hits	497	Shared Neighborhood Hits	19
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

SHAN2_MOUSE
θ value	0.365318 (rank : 32)	NC score	0.079809 (rank : 33)
Query Neighborhood Hits	102	Target Neighborhood Hits	446	Shared Neighborhood Hits	21
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

STK6_MOUSE
θ value	0.365318 (rank : 33)	NC score	0.008498 (rank : 188)
Query Neighborhood Hits	102	Target Neighborhood Hits	886	Shared Neighborhood Hits	13
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

GAB2_MOUSE
θ value	0.47712 (rank : 34)	NC score	0.029752 (rank : 156)
Query Neighborhood Hits	102	Target Neighborhood Hits	220	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

SFRIP_HUMAN
θ value	0.47712 (rank : 35)	NC score	0.057714 (rank : 82)
Query Neighborhood Hits	102	Target Neighborhood Hits	530	Shared Neighborhood Hits	20
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

CD2L7_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.015085 (rank : 176)
Query Neighborhood Hits	102	Target Neighborhood Hits	1275	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

EFS_MOUSE
θ value	0.813845 (rank : 37)	NC score	0.067686 (rank : 56)
Query Neighborhood Hits	102	Target Neighborhood Hits	389	Shared Neighborhood Hits	20
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

LPIN2_HUMAN
θ value	0.813845 (rank : 38)	NC score	0.032115 (rank : 150)
Query Neighborhood Hits	102	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q92539	Gene names	LPIN2, KIAA0249
Domain Architecture	No domain graphic available
Description	Lipin-2.

MILK1_MOUSE
θ value	0.813845 (rank : 39)	NC score	0.031580 (rank : 152)
Query Neighborhood Hits	102	Target Neighborhood Hits	788	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MRCKG_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.018197 (rank : 174)
Query Neighborhood Hits	102	Target Neighborhood Hits	1519	Shared Neighborhood Hits	27
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

NACAM_MOUSE
θ value	0.813845 (rank : 41)	NC score	0.040945 (rank : 138)
Query Neighborhood Hits	102	Target Neighborhood Hits	1866	Shared Neighborhood Hits	42
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ASXL1_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.044787 (rank : 133)
Query Neighborhood Hits	102	Target Neighborhood Hits	182	Shared Neighborhood Hits	10
SwissProt Accessions	P59598	Gene names	Asxl1, Kiaa0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

KPSH1_HUMAN
θ value	1.06291 (rank : 43)	NC score	0.007951 (rank : 192)
Query Neighborhood Hits	102	Target Neighborhood Hits	842	Shared Neighborhood Hits	12
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

SN1L1_MOUSE
θ value	1.06291 (rank : 44)	NC score	0.009071 (rank : 187)
Query Neighborhood Hits	102	Target Neighborhood Hits	895	Shared Neighborhood Hits	17
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

ENSA_MOUSE
θ value	1.38821 (rank : 45)	NC score	0.051060 (rank : 112)
Query Neighborhood Hits	102	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P60840, Q9CQZ9, Q9Z0G1	Gene names	Ensa
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

LPIN2_MOUSE
θ value	1.38821 (rank : 46)	NC score	0.030595 (rank : 155)
Query Neighborhood Hits	102	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PI5, Q8C357, Q8C7I8, Q8CC85, Q8CHR7	Gene names	Lpin2
Domain Architecture
Description	Lipin-2.

MA1B1_HUMAN
θ value	1.38821 (rank : 47)	NC score	0.029696 (rank : 157)
Query Neighborhood Hits	102	Target Neighborhood Hits	125	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

MCPH1_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.030950 (rank : 154)
Query Neighborhood Hits	102	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEM0, Q66GU1, Q9H9C7	Gene names	MCPH1
Domain Architecture
Description	Microcephalin.

NCOA6_MOUSE
θ value	1.38821 (rank : 49)	NC score	0.049191 (rank : 127)
Query Neighborhood Hits	102	Target Neighborhood Hits	1076	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RBBP6_MOUSE
θ value	1.38821 (rank : 50)	NC score	0.037191 (rank : 144)
Query Neighborhood Hits	102	Target Neighborhood Hits	1014	Shared Neighborhood Hits	23
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

SKI_MOUSE
θ value	1.38821 (rank : 51)	NC score	0.051356 (rank : 111)
Query Neighborhood Hits	102	Target Neighborhood Hits	423	Shared Neighborhood Hits	13
SwissProt Accessions	Q60698, Q8VIL5	Gene names	Ski
Domain Architecture	No domain graphic available
Description	Ski oncogene (C-ski).

TARA_HUMAN
θ value	1.38821 (rank : 52)	NC score	0.043017 (rank : 136)
Query Neighborhood Hits	102	Target Neighborhood Hits	1626	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ABL1_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.014078 (rank : 178)
Query Neighborhood Hits	102	Target Neighborhood Hits	1220	Shared Neighborhood Hits	33
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CHD5_HUMAN
θ value	1.81305 (rank : 54)	NC score	0.008498 (rank : 189)
Query Neighborhood Hits	102	Target Neighborhood Hits	349	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

MDC1_MOUSE
θ value	1.81305 (rank : 55)	NC score	0.029367 (rank : 158)
Query Neighborhood Hits	102	Target Neighborhood Hits	998	Shared Neighborhood Hits	31
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PCYOX_MOUSE
θ value	1.81305 (rank : 56)	NC score	0.028537 (rank : 159)
Query Neighborhood Hits	102	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQF9, Q3UHV6, Q69ZW0, Q8BZX1	Gene names	Pcyox1, Kiaa0908
Domain Architecture	No domain graphic available
Description	Prenylcysteine oxidase precursor (EC 1.8.3.5).

RS6_HUMAN
θ value	1.81305 (rank : 57)	NC score	0.064523 (rank : 72)
Query Neighborhood Hits	102	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	P62753, P08227, P10660, Q4VBY7, Q8N6Z7	Gene names	RPS6
Domain Architecture	No domain graphic available
Description	40S ribosomal protein S6 (Phosphoprotein NP33).

RS6_MOUSE
θ value	1.81305 (rank : 58)	NC score	0.064523 (rank : 73)
Query Neighborhood Hits	102	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	P62754, P08227, P10660	Gene names	Rps6
Domain Architecture	No domain graphic available
Description	40S ribosomal protein S6 (Phosphoprotein NP33).

SHD_HUMAN
θ value	1.81305 (rank : 59)	NC score	0.019604 (rank : 173)
Query Neighborhood Hits	102	Target Neighborhood Hits	204	Shared Neighborhood Hits	7
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ENSA_HUMAN
θ value	2.36792 (rank : 60)	NC score	0.047764 (rank : 128)
Query Neighborhood Hits	102	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	O43768, Q9NRZ0	Gene names	ENSA
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

ERRFI_MOUSE
θ value	2.36792 (rank : 61)	NC score	0.036846 (rank : 146)
Query Neighborhood Hits	102	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

KIFC3_MOUSE
θ value	2.36792 (rank : 62)	NC score	0.037776 (rank : 143)
Query Neighborhood Hits	102	Target Neighborhood Hits	571	Shared Neighborhood Hits	19
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

NCOA6_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.040823 (rank : 139)
Query Neighborhood Hits	102	Target Neighborhood Hits	1202	Shared Neighborhood Hits	30
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PLSL_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.051527 (rank : 110)
Query Neighborhood Hits	102	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	Q61233, Q3UE24, Q8R1X3, Q9CV77	Gene names	Lcp1, Pls2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (pp65).

RBBP6_HUMAN
θ value	2.36792 (rank : 65)	NC score	0.039016 (rank : 141)
Query Neighborhood Hits	102	Target Neighborhood Hits	1135	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

SLC2B_HUMAN
θ value	2.36792 (rank : 66)	NC score	0.036866 (rank : 145)
Query Neighborhood Hits	102	Target Neighborhood Hits	214	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

YAF2_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.026533 (rank : 162)
Query Neighborhood Hits	102	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IY57, Q99710	Gene names	YAF2
Domain Architecture
Description	YY1-associated factor 2.

ZCH11_HUMAN
θ value	2.36792 (rank : 68)	NC score	0.022904 (rank : 168)
Query Neighborhood Hits	102	Target Neighborhood Hits	278	Shared Neighborhood Hits	9
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

BAT2_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.045625 (rank : 131)
Query Neighborhood Hits	102	Target Neighborhood Hits	931	Shared Neighborhood Hits	32
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAT2_MOUSE
θ value	3.0926 (rank : 70)	NC score	0.043444 (rank : 135)
Query Neighborhood Hits	102	Target Neighborhood Hits	947	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

FMN2_HUMAN
θ value	3.0926 (rank : 71)	NC score	0.025397 (rank : 164)
Query Neighborhood Hits	102	Target Neighborhood Hits	484	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

PAX9_HUMAN
θ value	3.0926 (rank : 72)	NC score	0.011688 (rank : 183)
Query Neighborhood Hits	102	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P55771, Q99582, Q9UQR4	Gene names	PAX9
Domain Architecture
Description	Paired box protein Pax-9.

ROCK2_MOUSE
θ value	3.0926 (rank : 73)	NC score	0.031526 (rank : 153)
Query Neighborhood Hits	102	Target Neighborhood Hits	2072	Shared Neighborhood Hits	36
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

RUNX1_HUMAN
θ value	3.0926 (rank : 74)	NC score	0.025954 (rank : 163)
Query Neighborhood Hits	102	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q01196, O60472, O60473, O76047, O76089, Q13081, Q13755, Q13756, Q13757, Q13758, Q13759, Q15341, Q15343, Q16122, Q16284, Q16285, Q16286, Q16346, Q16347, Q92479	Gene names	RUNX1, AML1, CBFA2
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

TGON2_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.032850 (rank : 149)
Query Neighborhood Hits	102	Target Neighborhood Hits	1037	Shared Neighborhood Hits	26
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TRAK1_HUMAN
θ value	3.0926 (rank : 76)	NC score	0.062367 (rank : 78)
Query Neighborhood Hits	102	Target Neighborhood Hits	660	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

K0141_HUMAN
θ value	4.03905 (rank : 77)	NC score	0.020426 (rank : 171)
Query Neighborhood Hits	102	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q14154, Q969R4, Q96EU9	Gene names	KIAA0141
Domain Architecture
Description	Protein KIAA0141.

PLSL_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.044648 (rank : 134)
Query Neighborhood Hits	102	Target Neighborhood Hits	168	Shared Neighborhood Hits	12
SwissProt Accessions	P13796	Gene names	LCP1, PLS2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P).

SAPS1_HUMAN
θ value	4.03905 (rank : 79)	NC score	0.022849 (rank : 169)
Query Neighborhood Hits	102	Target Neighborhood Hits	704	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

TSH3_MOUSE
θ value	4.03905 (rank : 80)	NC score	0.012608 (rank : 180)
Query Neighborhood Hits	102	Target Neighborhood Hits	590	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CGV9, Q5DTX4	Gene names	Tshz3, Kiaa1474, Tsh3, Zfp537, Znf537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

ANC1_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.023964 (rank : 167)
Query Neighborhood Hits	102	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H1A4, Q9BSE6, Q9H8D0	Gene names	ANAPC1, TSG24
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Protein Tsg24) (Mitotic checkpoint regulator).

ANC1_MOUSE
θ value	5.27518 (rank : 82)	NC score	0.023968 (rank : 166)
Query Neighborhood Hits	102	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P53995, Q8BP33, Q8C772	Gene names	Anapc1, Mcpr, Tsg24
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Protein Tsg24) (Mitotic checkpoint regulator).

CBP_MOUSE
θ value	5.27518 (rank : 83)	NC score	0.019681 (rank : 172)
Query Neighborhood Hits	102	Target Neighborhood Hits	1051	Shared Neighborhood Hits	25
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

ICK_MOUSE
θ value	5.27518 (rank : 84)	NC score	0.008121 (rank : 191)
Query Neighborhood Hits	102	Target Neighborhood Hits	860	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

SKI_HUMAN
θ value	5.27518 (rank : 85)	NC score	0.053560 (rank : 101)
Query Neighborhood Hits	102	Target Neighborhood Hits	423	Shared Neighborhood Hits	17
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

DPOLL_MOUSE
θ value	6.88961 (rank : 86)	NC score	0.011167 (rank : 185)
Query Neighborhood Hits	102	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXE2, Q9CTJ1	Gene names	Poll, Polk
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa).

FA5_HUMAN
θ value	6.88961 (rank : 87)	NC score	0.014430 (rank : 177)
Query Neighborhood Hits	102	Target Neighborhood Hits	172	Shared Neighborhood Hits	8
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

KIFC3_HUMAN
θ value	6.88961 (rank : 88)	NC score	0.039089 (rank : 140)
Query Neighborhood Hits	102	Target Neighborhood Hits	619	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KPSH1_MOUSE
θ value	6.88961 (rank : 89)	NC score	0.006609 (rank : 193)
Query Neighborhood Hits	102	Target Neighborhood Hits	839	Shared Neighborhood Hits	12
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

MAP9_MOUSE
θ value	6.88961 (rank : 90)	NC score	0.027048 (rank : 161)
Query Neighborhood Hits	102	Target Neighborhood Hits	529	Shared Neighborhood Hits	15
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

ROCK2_HUMAN
θ value	6.88961 (rank : 91)	NC score	0.027256 (rank : 160)
Query Neighborhood Hits	102	Target Neighborhood Hits	2073	Shared Neighborhood Hits	33
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

RPGR1_HUMAN
θ value	6.88961 (rank : 92)	NC score	0.042212 (rank : 137)
Query Neighborhood Hits	102	Target Neighborhood Hits	578	Shared Neighborhood Hits	19
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

TRIPB_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.044862 (rank : 132)
Query Neighborhood Hits	102	Target Neighborhood Hits	1587	Shared Neighborhood Hits	27
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ZO1_MOUSE
θ value	6.88961 (rank : 94)	NC score	0.008201 (rank : 190)
Query Neighborhood Hits	102	Target Neighborhood Hits	453	Shared Neighborhood Hits	14
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ARP19_HUMAN
θ value	8.99809 (rank : 95)	NC score	0.036298 (rank : 148)
Query Neighborhood Hits	102	Target Neighborhood Hits	6	Shared Neighborhood Hits	5
SwissProt Accessions	P56211, Q6IAM2, Q86TA6, Q9UD70	Gene names	ARPP19
Domain Architecture
Description	cAMP-regulated phosphoprotein 19 (ARPP-19).

ARP19_MOUSE
θ value	8.99809 (rank : 96)	NC score	0.036303 (rank : 147)
Query Neighborhood Hits	102	Target Neighborhood Hits	6	Shared Neighborhood Hits	5
SwissProt Accessions	P56212, Q543L2	Gene names	Arpp19
Domain Architecture
Description	cAMP-regulated phosphoprotein 19 (ARPP-19).

CTND2_HUMAN
θ value	8.99809 (rank : 97)	NC score	0.012308 (rank : 182)
Query Neighborhood Hits	102	Target Neighborhood Hits	333	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

CTND2_MOUSE
θ value	8.99809 (rank : 98)	NC score	0.009907 (rank : 186)
Query Neighborhood Hits	102	Target Neighborhood Hits	227	Shared Neighborhood Hits	10
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

FBX46_MOUSE
θ value	8.99809 (rank : 99)	NC score	0.011233 (rank : 184)
Query Neighborhood Hits	102	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

IF4B_HUMAN
θ value	8.99809 (rank : 100)	NC score	0.016838 (rank : 175)
Query Neighborhood Hits	102	Target Neighborhood Hits	417	Shared Neighborhood Hits	14
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

K1802_MOUSE
θ value	8.99809 (rank : 101)	NC score	0.012450 (rank : 181)
Query Neighborhood Hits	102	Target Neighborhood Hits	1596	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SEPT9_MOUSE
θ value	8.99809 (rank : 102)	NC score	0.024561 (rank : 165)
Query Neighborhood Hits	102	Target Neighborhood Hits	238	Shared Neighborhood Hits	7
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

ABI1_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.054975 (rank : 94)
Query Neighborhood Hits	102	Target Neighborhood Hits	257	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.054203 (rank : 95)
Query Neighborhood Hits	102	Target Neighborhood Hits	246	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.057427 (rank : 83)
Query Neighborhood Hits	102	Target Neighborhood Hits	350	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.055574 (rank : 89)
Query Neighborhood Hits	102	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.053423 (rank : 102)
Query Neighborhood Hits	102	Target Neighborhood Hits	227	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.053991 (rank : 98)
Query Neighborhood Hits	102	Target Neighborhood Hits	227	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG1_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.077964 (rank : 36)
Query Neighborhood Hits	102	Target Neighborhood Hits	176	Shared Neighborhood Hits	8
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.077304 (rank : 37)
Query Neighborhood Hits	102	Target Neighborhood Hits	266	Shared Neighborhood Hits	8
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.067256 (rank : 58)
Query Neighborhood Hits	102	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.068890 (rank : 54)
Query Neighborhood Hits	102	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.083489 (rank : 27)
Query Neighborhood Hits	102	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.082520 (rank : 29)
Query Neighborhood Hits	102	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.062906 (rank : 77)
Query Neighborhood Hits	102	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.066633 (rank : 63)
Query Neighborhood Hits	102	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.065897 (rank : 66)
Query Neighborhood Hits	102	Target Neighborhood Hits	172	Shared Neighborhood Hits	5
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG6_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.066535 (rank : 64)
Query Neighborhood Hits	102	Target Neighborhood Hits	376	Shared Neighborhood Hits	11
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.066794 (rank : 60)
Query Neighborhood Hits	102	Target Neighborhood Hits	394	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.064478 (rank : 74)
Query Neighborhood Hits	102	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.066749 (rank : 61)
Query Neighborhood Hits	102	Target Neighborhood Hits	396	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.084087 (rank : 24)
Query Neighborhood Hits	102	Target Neighborhood Hits	85	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.083098 (rank : 28)
Query Neighborhood Hits	102	Target Neighborhood Hits	79	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.065161 (rank : 68)
Query Neighborhood Hits	102	Target Neighborhood Hits	235	Shared Neighborhood Hits	7
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.065043 (rank : 70)
Query Neighborhood Hits	102	Target Neighborhood Hits	234	Shared Neighborhood Hits	7
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.067438 (rank : 57)
Query Neighborhood Hits	102	Target Neighborhood Hits	187	Shared Neighborhood Hits	8
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.069240 (rank : 51)
Query Neighborhood Hits	102	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.079905 (rank : 32)
Query Neighborhood Hits	102	Target Neighborhood Hits	375	Shared Neighborhood Hits	10
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.078217 (rank : 35)
Query Neighborhood Hits	102	Target Neighborhood Hits	351	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.078514 (rank : 34)
Query Neighborhood Hits	102	Target Neighborhood Hits	344	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.083507 (rank : 26)
Query Neighborhood Hits	102	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.080990 (rank : 31)
Query Neighborhood Hits	102	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.083552 (rank : 25)
Query Neighborhood Hits	102	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

AZI1_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.053810 (rank : 100)
Query Neighborhood Hits	102	Target Neighborhood Hits	1000	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CCD96_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.051900 (rank : 108)
Query Neighborhood Hits	102	Target Neighborhood Hits	704	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCDC6_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.054118 (rank : 96)
Query Neighborhood Hits	102	Target Neighborhood Hits	723	Shared Neighborhood Hits	26
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CD2AP_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.072952 (rank : 43)
Query Neighborhood Hits	102	Target Neighborhood Hits	315	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.076063 (rank : 40)
Query Neighborhood Hits	102	Target Neighborhood Hits	336	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CEP57_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.055502 (rank : 90)
Query Neighborhood Hits	102	Target Neighborhood Hits	576	Shared Neighborhood Hits	17
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

CEP57_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.056782 (rank : 84)
Query Neighborhood Hits	102	Target Neighborhood Hits	580	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

CT096_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.050627 (rank : 116)
Query Neighborhood Hits	102	Target Neighborhood Hits	438	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

CT2NL_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.053274 (rank : 103)
Query Neighborhood Hits	102	Target Neighborhood Hits	1059	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

DNMBP_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.060117 (rank : 79)
Query Neighborhood Hits	102	Target Neighborhood Hits	413	Shared Neighborhood Hits	12
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.066482 (rank : 65)
Query Neighborhood Hits	102	Target Neighborhood Hits	435	Shared Neighborhood Hits	17
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ECT2_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.050511 (rank : 119)
Query Neighborhood Hits	102	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EFS_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.050011 (rank : 125)
Query Neighborhood Hits	102	Target Neighborhood Hits	348	Shared Neighborhood Hits	18
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

FGD6_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.056653 (rank : 85)
Query Neighborhood Hits	102	Target Neighborhood Hits	282	Shared Neighborhood Hits	10
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GNRP_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.054010 (rank : 97)
Query Neighborhood Hits	102	Target Neighborhood Hits	239	Shared Neighborhood Hits	7
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.052912 (rank : 105)
Query Neighborhood Hits	102	Target Neighborhood Hits	191	Shared Neighborhood Hits	5
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GOGA2_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.059660 (rank : 80)
Query Neighborhood Hits	102	Target Neighborhood Hits	856	Shared Neighborhood Hits	24
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

GRAP_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.050108 (rank : 123)
Query Neighborhood Hits	102	Target Neighborhood Hits	307	Shared Neighborhood Hits	9
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.050015 (rank : 124)
Query Neighborhood Hits	102	Target Neighborhood Hits	309	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

HCLS1_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.053912 (rank : 99)
Query Neighborhood Hits	102	Target Neighborhood Hits	358	Shared Neighborhood Hits	13
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.056466 (rank : 86)
Query Neighborhood Hits	102	Target Neighborhood Hits	329	Shared Neighborhood Hits	16
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IFT74_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.050564 (rank : 117)
Query Neighborhood Hits	102	Target Neighborhood Hits	949	Shared Neighborhood Hits	20
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

LBC_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.065344 (rank : 67)
Query Neighborhood Hits	102	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

NCF1_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.073660 (rank : 42)
Query Neighborhood Hits	102	Target Neighborhood Hits	198	Shared Neighborhood Hits	7
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.076212 (rank : 39)
Query Neighborhood Hits	102	Target Neighborhood Hits	198	Shared Neighborhood Hits	7
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.065096 (rank : 69)
Query Neighborhood Hits	102	Target Neighborhood Hits	229	Shared Neighborhood Hits	5
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.056057 (rank : 88)
Query Neighborhood Hits	102	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.050960 (rank : 113)
Query Neighborhood Hits	102	Target Neighborhood Hits	177	Shared Neighborhood Hits	5
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.071829 (rank : 45)
Query Neighborhood Hits	102	Target Neighborhood Hits	312	Shared Neighborhood Hits	9
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.067069 (rank : 59)
Query Neighborhood Hits	102	Target Neighborhood Hits	310	Shared Neighborhood Hits	9
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NGEF_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.075256 (rank : 41)
Query Neighborhood Hits	102	Target Neighborhood Hits	166	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.077025 (rank : 38)
Query Neighborhood Hits	102	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.063857 (rank : 76)
Query Neighborhood Hits	102	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.070260 (rank : 49)
Query Neighborhood Hits	102	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PCQAP_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.050513 (rank : 118)
Query Neighborhood Hits	102	Target Neighborhood Hits	549	Shared Neighborhood Hits	26
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PCQAP_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.055484 (rank : 91)
Query Neighborhood Hits	102	Target Neighborhood Hits	506	Shared Neighborhood Hits	23
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PKHG1_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.051557 (rank : 109)
Query Neighborhood Hits	102	Target Neighborhood Hits	174	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PREX1_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.055450 (rank : 92)
Query Neighborhood Hits	102	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RFIP3_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.052466 (rank : 106)
Query Neighborhood Hits	102	Target Neighborhood Hits	1055	Shared Neighborhood Hits	25
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RGNEF_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.072480 (rank : 44)
Query Neighborhood Hits	102	Target Neighborhood Hits	641	Shared Neighborhood Hits	17
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SH3K1_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.082255 (rank : 30)
Query Neighborhood Hits	102	Target Neighborhood Hits	341	Shared Neighborhood Hits	12
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.070639 (rank : 47)
Query Neighborhood Hits	102	Target Neighborhood Hits	332	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.056072 (rank : 87)
Query Neighborhood Hits	102	Target Neighborhood Hits	396	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.069736 (rank : 50)
Query Neighborhood Hits	102	Target Neighborhood Hits	409	Shared Neighborhood Hits	14
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRCA_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.201262 (rank : 21)
Query Neighborhood Hits	102	Target Neighborhood Hits	380	Shared Neighborhood Hits	19
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SRCA_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.211988 (rank : 20)
Query Neighborhood Hits	102	Target Neighborhood Hits	212	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

STAC3_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.050164 (rank : 122)
Query Neighborhood Hits	102	Target Neighborhood Hits	228	Shared Neighborhood Hits	7
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.050807 (rank : 115)
Query Neighborhood Hits	102	Target Neighborhood Hits	232	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.050878 (rank : 114)
Query Neighborhood Hits	102	Target Neighborhood Hits	273	Shared Neighborhood Hits	7
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SYNG_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.090871 (rank : 23)
Query Neighborhood Hits	102	Target Neighborhood Hits	160	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

SYNG_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.106172 (rank : 22)
Query Neighborhood Hits	102	Target Neighborhood Hits	206	Shared Neighborhood Hits	23
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

TAXB1_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.050368 (rank : 121)
Query Neighborhood Hits	102	Target Neighborhood Hits	829	Shared Neighborhood Hits	18
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TIAM1_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.064130 (rank : 75)
Query Neighborhood Hits	102	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.066674 (rank : 62)
Query Neighborhood Hits	102	Target Neighborhood Hits	205	Shared Neighborhood Hits	8
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRAIP_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.055363 (rank : 93)
Query Neighborhood Hits	102	Target Neighborhood Hits	745	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

TSC1_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.053103 (rank : 104)
Query Neighborhood Hits	102	Target Neighborhood Hits	765	Shared Neighborhood Hits	25
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

TUFT1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.057935 (rank : 81)
Query Neighborhood Hits	102	Target Neighborhood Hits	686	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

TUFT1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.052082 (rank : 107)
Query Neighborhood Hits	102	Target Neighborhood Hits	732	Shared Neighborhood Hits	19
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

VINEX_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.069003 (rank : 53)
Query Neighborhood Hits	102	Target Neighborhood Hits	270	Shared Neighborhood Hits	7
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.070336 (rank : 48)
Query Neighborhood Hits	102	Target Neighborhood Hits	286	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

REPS2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	102	Target Neighborhood Hits	102	Shared Neighborhood Hits	102
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_HUMAN
NC score	0.967026 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	102	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS1_MOUSE
NC score	0.805620 (rank : 3)	θ value	3.16345e-37 (rank : 3)
Query Neighborhood Hits	102	Target Neighborhood Hits	204	Shared Neighborhood Hits	26
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_HUMAN
NC score	0.797333 (rank : 4)	θ value	1.57e-36 (rank : 4)
Query Neighborhood Hits	102	Target Neighborhood Hits	205	Shared Neighborhood Hits	29
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

EHD4_MOUSE
NC score	0.539737 (rank : 5)	θ value	2.28291e-11 (rank : 10)
Query Neighborhood Hits	102	Target Neighborhood Hits	40	Shared Neighborhood Hits	19
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

EHD4_HUMAN
NC score	0.535548 (rank : 6)	θ value	2.28291e-11 (rank : 9)
Query Neighborhood Hits	102	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H223, Q9HAR1, Q9NZN2	Gene names	EHD4, HCA10, HCA11
Domain Architecture
Description	EH-domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11).

EHD2_HUMAN
NC score	0.533576 (rank : 7)	θ value	2.79066e-09 (rank : 14)
Query Neighborhood Hits	102	Target Neighborhood Hits	29	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD1_HUMAN
NC score	0.524172 (rank : 8)	θ value	3.08544e-08 (rank : 16)
Query Neighborhood Hits	102	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
NC score	0.523569 (rank : 9)	θ value	4.0297e-08 (rank : 17)
Query Neighborhood Hits	102	Target Neighborhood Hits	37	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EHD3_MOUSE
NC score	0.519738 (rank : 10)	θ value	8.97725e-08 (rank : 18)
Query Neighborhood Hits	102	Target Neighborhood Hits	34	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD3_HUMAN
NC score	0.515419 (rank : 11)	θ value	4.45536e-07 (rank : 19)
Query Neighborhood Hits	102	Target Neighborhood Hits	33	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

EP15_MOUSE
NC score	0.394571 (rank : 12)	θ value	6.64225e-11 (rank : 12)
Query Neighborhood Hits	102	Target Neighborhood Hits	820	Shared Neighborhood Hits	35
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_HUMAN
NC score	0.375559 (rank : 13)	θ value	6.64225e-11 (rank : 11)
Query Neighborhood Hits	102	Target Neighborhood Hits	1021	Shared Neighborhood Hits	32
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15R_MOUSE
NC score	0.336233 (rank : 14)	θ value	6.21693e-09 (rank : 15)
Query Neighborhood Hits	102	Target Neighborhood Hits	1135	Shared Neighborhood Hits	38
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15R_HUMAN
NC score	0.330586 (rank : 15)	θ value	1.25267e-09 (rank : 13)
Query Neighborhood Hits	102	Target Neighborhood Hits	1083	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

ITSN2_HUMAN
NC score	0.295800 (rank : 16)	θ value	6.00763e-12 (rank : 8)
Query Neighborhood Hits	102	Target Neighborhood Hits	1173	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
NC score	0.284351 (rank : 17)	θ value	3.52202e-12 (rank : 7)
Query Neighborhood Hits	102	Target Neighborhood Hits	1371	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_MOUSE
NC score	0.280509 (rank : 18)	θ value	1.58096e-12 (rank : 6)
Query Neighborhood Hits	102	Target Neighborhood Hits	1669	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.280216 (rank : 19)	θ value	8.38298e-14 (rank : 5)
Query Neighborhood Hits	102	Target Neighborhood Hits	1757	Shared Neighborhood Hits	46
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SRCA_MOUSE
NC score	0.211988 (rank : 20)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	102	Target Neighborhood Hits	212	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SRCA_HUMAN
NC score	0.201262 (rank : 21)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	102	Target Neighborhood Hits	380	Shared Neighborhood Hits	19
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SYNG_MOUSE
NC score	0.106172 (rank : 22)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	102	Target Neighborhood Hits	206	Shared Neighborhood Hits	23
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

SYNG_HUMAN
NC score	0.090871 (rank : 23)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	102	Target Neighborhood Hits	160	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

ARHG8_HUMAN
NC score	0.084087 (rank : 24)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	102	Target Neighborhood Hits	85	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGG_MOUSE
NC score	0.083552 (rank : 25)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	102	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGF_HUMAN
NC score	0.083507 (rank : 26)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	102	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG3_HUMAN
NC score	0.083489 (rank : 27)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	102	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG8_MOUSE
NC score	0.083098 (rank : 28)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	102	Target Neighborhood Hits	79	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG3_MOUSE
NC score	0.082520 (rank : 29)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	102	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

SH3K1_HUMAN
NC score	0.082255 (rank : 30)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	102	Target Neighborhood Hits	341	Shared Neighborhood Hits	12
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ARHGG_HUMAN
NC score	0.080990 (rank : 31)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	102	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGB_HUMAN
NC score	0.079905 (rank : 32)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	102	Target Neighborhood Hits	375	Shared Neighborhood Hits	10
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SHAN2_MOUSE
NC score	0.079809 (rank : 33)	θ value	0.365318 (rank : 32)
Query Neighborhood Hits	102	Target Neighborhood Hits	446	Shared Neighborhood Hits	21
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ARHGC_MOUSE
NC score	0.078514 (rank : 34)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	102	Target Neighborhood Hits	344	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.078217 (rank : 35)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	102	Target Neighborhood Hits	351	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_HUMAN
NC score	0.077964 (rank : 36)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	102	Target Neighborhood Hits	176	Shared Neighborhood Hits	8
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.077304 (rank : 37)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	102	Target Neighborhood Hits	266	Shared Neighborhood Hits	8
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

NGEF_MOUSE
NC score	0.077025 (rank : 38)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	102	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NCF1_MOUSE
NC score	0.076212 (rank : 39)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	102	Target Neighborhood Hits	198	Shared Neighborhood Hits	7
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CD2AP_MOUSE
NC score	0.076063 (rank : 40)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	102	Target Neighborhood Hits	336	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NGEF_HUMAN
NC score	0.075256 (rank : 41)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	102	Target Neighborhood Hits	166	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NCF1_HUMAN
NC score	0.073660 (rank : 42)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	102	Target Neighborhood Hits	198	Shared Neighborhood Hits	7
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CD2AP_HUMAN
NC score	0.072952 (rank : 43)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	102	Target Neighborhood Hits	315	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

RGNEF_MOUSE
NC score	0.072480 (rank : 44)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	102	Target Neighborhood Hits	641	Shared Neighborhood Hits	17
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

NCK1_HUMAN
NC score	0.071829 (rank : 45)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	102	Target Neighborhood Hits	312	Shared Neighborhood Hits	9
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GOGA2_MOUSE
NC score	0.071235 (rank : 46)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	102	Target Neighborhood Hits	944	Shared Neighborhood Hits	27
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

SH3K1_MOUSE
NC score	0.070639 (rank : 47)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	102	Target Neighborhood Hits	332	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

VINEX_MOUSE
NC score	0.070336 (rank : 48)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	102	Target Neighborhood Hits	286	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NOXO1_MOUSE
NC score	0.070260 (rank : 49)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	102	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SRBS1_MOUSE
NC score	0.069736 (rank : 50)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	102	Target Neighborhood Hits	409	Shared Neighborhood Hits	14
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ARHGA_MOUSE
NC score	0.069240 (rank : 51)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	102	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

BLNK_MOUSE
NC score	0.069005 (rank : 52)	θ value	0.21417 (rank : 27)
Query Neighborhood Hits	102	Target Neighborhood Hits	296	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

VINEX_HUMAN
NC score	0.069003 (rank : 53)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	102	Target Neighborhood Hits	270	Shared Neighborhood Hits	7
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ARHG2_MOUSE
NC score	0.068890 (rank : 54)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	102	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

SHAN2_HUMAN
NC score	0.068221 (rank : 55)	θ value	0.0193708 (rank : 21)
Query Neighborhood Hits	102	Target Neighborhood Hits	346	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

EFS_MOUSE
NC score	0.067686 (rank : 56)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	102	Target Neighborhood Hits	389	Shared Neighborhood Hits	20
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ARHGA_HUMAN
NC score	0.067438 (rank : 57)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	102	Target Neighborhood Hits	187	Shared Neighborhood Hits	8
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG2_HUMAN
NC score	0.067256 (rank : 58)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	102	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

NCK2_HUMAN
NC score	0.067069 (rank : 59)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	102	Target Neighborhood Hits	310	Shared Neighborhood Hits	9
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG6_MOUSE
NC score	0.066794 (rank : 60)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	102	Target Neighborhood Hits	394	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_MOUSE
NC score	0.066749 (rank : 61)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	102	Target Neighborhood Hits	396	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

TIAM1_MOUSE
NC score	0.066674 (rank : 62)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	102	Target Neighborhood Hits	205	Shared Neighborhood Hits	8
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG4_MOUSE
NC score	0.066633 (rank : 63)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	102	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
NC score	0.066535 (rank : 64)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	102	Target Neighborhood Hits	376	Shared Neighborhood Hits	11
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

DNMBP_MOUSE
NC score	0.066482 (rank : 65)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	102	Target Neighborhood Hits	435	Shared Neighborhood Hits	17
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG5_HUMAN
NC score	0.065897 (rank : 66)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	102	Target Neighborhood Hits	172	Shared Neighborhood Hits	5
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

LBC_HUMAN
NC score	0.065344 (rank : 67)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	102	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG9_HUMAN
NC score	0.065161 (rank : 68)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	102	Target Neighborhood Hits	235	Shared Neighborhood Hits	7
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

NCF2_HUMAN
NC score	0.065096 (rank : 69)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	102	Target Neighborhood Hits	229	Shared Neighborhood Hits	5
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ARHG9_MOUSE
NC score	0.065043 (rank : 70)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	102	Target Neighborhood Hits	234	Shared Neighborhood Hits	7
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

TP53B_HUMAN
NC score	0.064963 (rank : 71)	θ value	0.0330416 (rank : 23)
Query Neighborhood Hits	102	Target Neighborhood Hits	413	Shared Neighborhood Hits	13
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

RS6_HUMAN
NC score	0.064523 (rank : 72)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	102	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	P62753, P08227, P10660, Q4VBY7, Q8N6Z7	Gene names	RPS6
Domain Architecture	No domain graphic available
Description	40S ribosomal protein S6 (Phosphoprotein NP33).

RS6_MOUSE
NC score	0.064523 (rank : 73)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	102	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	P62754, P08227, P10660	Gene names	Rps6
Domain Architecture	No domain graphic available
Description	40S ribosomal protein S6 (Phosphoprotein NP33).

ARHG7_HUMAN
NC score	0.064478 (rank : 74)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	102	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

TIAM1_HUMAN
NC score	0.064130 (rank : 75)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	102	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

NOXO1_HUMAN
NC score	0.063857 (rank : 76)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	102	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

ARHG4_HUMAN
NC score	0.062906 (rank : 77)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	102	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TRAK1_HUMAN
NC score	0.062367 (rank : 78)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	102	Target Neighborhood Hits	660	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

DNMBP_HUMAN
NC score	0.060117 (rank : 79)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	102	Target Neighborhood Hits	413	Shared Neighborhood Hits	12
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GOGA2_HUMAN
NC score	0.059660 (rank : 80)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	102	Target Neighborhood Hits	856	Shared Neighborhood Hits	24
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

TUFT1_HUMAN
NC score	0.057935 (rank : 81)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	102	Target Neighborhood Hits	686	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

SFRIP_HUMAN
NC score	0.057714 (rank : 82)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	102	Target Neighborhood Hits	530	Shared Neighborhood Hits	20
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

ABI2_HUMAN
NC score	0.057427 (rank : 83)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	102	Target Neighborhood Hits	350	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

CEP57_MOUSE
NC score	0.056782 (rank : 84)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	102	Target Neighborhood Hits	580	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

FGD6_MOUSE
NC score	0.056653 (rank : 85)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	102	Target Neighborhood Hits	282	Shared Neighborhood Hits	10
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

HCLS1_MOUSE
NC score	0.056466 (rank : 86)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	102	Target Neighborhood Hits	329	Shared Neighborhood Hits	16
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRBS1_HUMAN
NC score	0.056072 (rank : 87)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	102	Target Neighborhood Hits	396	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF4_HUMAN
NC score	0.056057 (rank : 88)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	102	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI2_MOUSE
NC score	0.055574 (rank : 89)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	102	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CEP57_HUMAN
NC score	0.055502 (rank : 90)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	102	Target Neighborhood Hits	576	Shared Neighborhood Hits	17
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

PCQAP_MOUSE
NC score	0.055484 (rank : 91)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	102	Target Neighborhood Hits	506	Shared Neighborhood Hits	23
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PREX1_HUMAN
NC score	0.055450 (rank : 92)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	102	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TRAIP_MOUSE
NC score	0.055363 (rank : 93)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	102	Target Neighborhood Hits	745	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

ABI1_HUMAN
NC score	0.054975 (rank : 94)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	102	Target Neighborhood Hits	257	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
NC score	0.054203 (rank : 95)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	102	Target Neighborhood Hits	246	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CCDC6_HUMAN
NC score	0.054118 (rank : 96)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	102	Target Neighborhood Hits	723	Shared Neighborhood Hits	26
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

GNRP_HUMAN
NC score	0.054010 (rank : 97)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	102	Target Neighborhood Hits	239	Shared Neighborhood Hits	7
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ABI3_MOUSE
NC score	0.053991 (rank : 98)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	102	Target Neighborhood Hits	227	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

HCLS1_HUMAN
NC score	0.053912 (rank : 99)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	102	Target Neighborhood Hits	358	Shared Neighborhood Hits	13
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

AZI1_HUMAN
NC score	0.053810 (rank : 100)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	102	Target Neighborhood Hits	1000	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

SKI_HUMAN
NC score	0.053560 (rank : 101)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	102	Target Neighborhood Hits	423	Shared Neighborhood Hits	17
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

ABI3_HUMAN
NC score	0.053423 (rank : 102)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	102	Target Neighborhood Hits	227	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CT2NL_HUMAN
NC score	0.053274 (rank : 103)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	102	Target Neighborhood Hits	1059	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

TSC1_HUMAN
NC score	0.053103 (rank : 104)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	102	Target Neighborhood Hits	765	Shared Neighborhood Hits	25
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

GNRP_MOUSE
NC score	0.052912 (rank : 105)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	102	Target Neighborhood Hits	191	Shared Neighborhood Hits	5
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RFIP3_HUMAN
NC score	0.052466 (rank : 106)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	102	Target Neighborhood Hits	1055	Shared Neighborhood Hits	25
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

TUFT1_MOUSE
NC score	0.052082 (rank : 107)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	102	Target Neighborhood Hits	732	Shared Neighborhood Hits	19
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

CCD96_MOUSE
NC score	0.051900 (rank : 108)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	102	Target Neighborhood Hits	704	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

PKHG1_HUMAN
NC score	0.051557 (rank : 109)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	102	Target Neighborhood Hits	174	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLSL_MOUSE
NC score	0.051527 (rank : 110)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	102	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	Q61233, Q3UE24, Q8R1X3, Q9CV77	Gene names	Lcp1, Pls2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (pp65).

SKI_MOUSE
NC score	0.051356 (rank : 111)	θ value	1.38821 (rank : 51)
Query Neighborhood Hits	102	Target Neighborhood Hits	423	Shared Neighborhood Hits	13
SwissProt Accessions	Q60698, Q8VIL5	Gene names	Ski
Domain Architecture	No domain graphic available
Description	Ski oncogene (C-ski).

ENSA_MOUSE
NC score	0.051060 (rank : 112)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	102	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P60840, Q9CQZ9, Q9Z0G1	Gene names	Ensa
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

NCF4_MOUSE
NC score	0.050960 (rank : 113)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	102	Target Neighborhood Hits	177	Shared Neighborhood Hits	5
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM1_MOUSE
NC score	0.050878 (rank : 114)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	102	Target Neighborhood Hits	273	Shared Neighborhood Hits	7
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC3_MOUSE
NC score	0.050807 (rank : 115)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	102	Target Neighborhood Hits	232	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CT096_HUMAN
NC score	0.050627 (rank : 116)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	102	Target Neighborhood Hits	438	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

IFT74_HUMAN
NC score	0.050564 (rank : 117)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	102	Target Neighborhood Hits	949	Shared Neighborhood Hits	20
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

PCQAP_HUMAN
NC score	0.050513 (rank : 118)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	102	Target Neighborhood Hits	549	Shared Neighborhood Hits	26
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

ECT2_MOUSE
NC score	0.050511 (rank : 119)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	102	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

K1543_MOUSE
NC score	0.050457 (rank : 120)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	102	Target Neighborhood Hits	497	Shared Neighborhood Hits	19
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

TAXB1_HUMAN
NC score	0.050368 (rank : 121)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	102	Target Neighborhood Hits	829	Shared Neighborhood Hits	18
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

STAC3_HUMAN
NC score	0.050164 (rank : 122)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	102	Target Neighborhood Hits	228	Shared Neighborhood Hits	7
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRAP_HUMAN
NC score	0.050108 (rank : 123)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	102	Target Neighborhood Hits	307	Shared Neighborhood Hits	9
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.050015 (rank : 124)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	102	Target Neighborhood Hits	309	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

EFS_HUMAN
NC score	0.050011 (rank : 125)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	102	Target Neighborhood Hits	348	Shared Neighborhood Hits	18
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SEPT9_HUMAN
NC score	0.049250 (rank : 126)	θ value	0.00665767 (rank : 20)
Query Neighborhood Hits	102	Target Neighborhood Hits	706	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

NCOA6_MOUSE
NC score	0.049191 (rank : 127)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	102	Target Neighborhood Hits	1076	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ENSA_HUMAN
NC score	0.047764 (rank : 128)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	102	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	O43768, Q9NRZ0	Gene names	ENSA
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

PITM2_HUMAN
NC score	0.046795 (rank : 129)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	102	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZ72, Q9P271	Gene names	PITPNM2, KIAA1457, NIR3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3).

RGS3_MOUSE
NC score	0.045632 (rank : 130)	θ value	0.0961366 (rank : 26)
Query Neighborhood Hits	102	Target Neighborhood Hits	1621	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

BAT2_HUMAN
NC score	0.045625 (rank : 131)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	102	Target Neighborhood Hits	931	Shared Neighborhood Hits	32
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

TRIPB_HUMAN
NC score	0.044862 (rank : 132)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	102	Target Neighborhood Hits	1587	Shared Neighborhood Hits	27
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ASXL1_MOUSE
NC score	0.044787 (rank : 133)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	102	Target Neighborhood Hits	182	Shared Neighborhood Hits	10
SwissProt Accessions	P59598	Gene names	Asxl1, Kiaa0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

PLSL_HUMAN
NC score	0.044648 (rank : 134)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	102	Target Neighborhood Hits	168	Shared Neighborhood Hits	12
SwissProt Accessions	P13796	Gene names	LCP1, PLS2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P).

BAT2_MOUSE
NC score	0.043444 (rank : 135)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	102	Target Neighborhood Hits	947	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

TARA_HUMAN
NC score	0.043017 (rank : 136)	θ value	1.38821 (rank : 52)
Query Neighborhood Hits	102	Target Neighborhood Hits	1626	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

RPGR1_HUMAN
NC score	0.042212 (rank : 137)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	102	Target Neighborhood Hits	578	Shared Neighborhood Hits	19
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

NACAM_MOUSE
NC score	0.040945 (rank : 138)	θ value	0.813845 (rank : 41)
Query Neighborhood Hits	102	Target Neighborhood Hits	1866	Shared Neighborhood Hits	42
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCOA6_HUMAN
NC score	0.040823 (rank : 139)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	102	Target Neighborhood Hits	1202	Shared Neighborhood Hits	30
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

KIFC3_HUMAN
NC score	0.039089 (rank : 140)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	102	Target Neighborhood Hits	619	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

RBBP6_HUMAN
NC score	0.039016 (rank : 141)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	102	Target Neighborhood Hits	1135	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RC3H1_MOUSE
NC score	0.038547 (rank : 142)	θ value	0.0563607 (rank : 24)
Query Neighborhood Hits	102	Target Neighborhood Hits	244	Shared Neighborhood Hits	3
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

KIFC3_MOUSE
NC score	0.037776 (rank : 143)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	102	Target Neighborhood Hits	571	Shared Neighborhood Hits	19
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

RBBP6_MOUSE
NC score	0.037191 (rank : 144)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	102	Target Neighborhood Hits	1014	Shared Neighborhood Hits	23
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

SLC2B_HUMAN
NC score	0.036866 (rank : 145)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	102	Target Neighborhood Hits	214	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

ERRFI_MOUSE
NC score	0.036846 (rank : 146)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	102	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

ARP19_MOUSE
NC score	0.036303 (rank : 147)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	102	Target Neighborhood Hits	6	Shared Neighborhood Hits	5
SwissProt Accessions	P56212, Q543L2	Gene names	Arpp19
Domain Architecture
Description	cAMP-regulated phosphoprotein 19 (ARPP-19).

ARP19_HUMAN
NC score	0.036298 (rank : 148)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	102	Target Neighborhood Hits	6	Shared Neighborhood Hits	5
SwissProt Accessions	P56211, Q6IAM2, Q86TA6, Q9UD70	Gene names	ARPP19
Domain Architecture
Description	cAMP-regulated phosphoprotein 19 (ARPP-19).

TGON2_HUMAN
NC score	0.032850 (rank : 149)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	102	Target Neighborhood Hits	1037	Shared Neighborhood Hits	26
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

LPIN2_HUMAN
NC score	0.032115 (rank : 150)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	102	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q92539	Gene names	LPIN2, KIAA0249
Domain Architecture	No domain graphic available
Description	Lipin-2.

MYT1_HUMAN
NC score	0.032020 (rank : 151)	θ value	0.279714 (rank : 30)
Query Neighborhood Hits	102	Target Neighborhood Hits	475	Shared Neighborhood Hits	10
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

MILK1_MOUSE
NC score	0.031580 (rank : 152)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	102	Target Neighborhood Hits	788	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

ROCK2_MOUSE
NC score	0.031526 (rank : 153)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	102	Target Neighborhood Hits	2072	Shared Neighborhood Hits	36
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

MCPH1_HUMAN
NC score	0.030950 (rank : 154)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	102	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEM0, Q66GU1, Q9H9C7	Gene names	MCPH1
Domain Architecture
Description	Microcephalin.

LPIN2_MOUSE
NC score	0.030595 (rank : 155)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	102	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PI5, Q8C357, Q8C7I8, Q8CC85, Q8CHR7	Gene names	Lpin2
Domain Architecture
Description	Lipin-2.

GAB2_MOUSE
NC score	0.029752 (rank : 156)	θ value	0.47712 (rank : 34)
Query Neighborhood Hits	102	Target Neighborhood Hits	220	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

MA1B1_HUMAN
NC score	0.029696 (rank : 157)	θ value	1.38821 (rank : 47)
Query Neighborhood Hits	102	Target Neighborhood Hits	125	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

MDC1_MOUSE
NC score	0.029367 (rank : 158)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	102	Target Neighborhood Hits	998	Shared Neighborhood Hits	31
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PCYOX_MOUSE
NC score	0.028537 (rank : 159)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	102	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQF9, Q3UHV6, Q69ZW0, Q8BZX1	Gene names	Pcyox1, Kiaa0908
Domain Architecture	No domain graphic available
Description	Prenylcysteine oxidase precursor (EC 1.8.3.5).

ROCK2_HUMAN
NC score	0.027256 (rank : 160)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	102	Target Neighborhood Hits	2073	Shared Neighborhood Hits	33
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

MAP9_MOUSE
NC score	0.027048 (rank : 161)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	102	Target Neighborhood Hits	529	Shared Neighborhood Hits	15
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

YAF2_HUMAN
NC score	0.026533 (rank : 162)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	102	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IY57, Q99710	Gene names	YAF2
Domain Architecture
Description	YY1-associated factor 2.

RUNX1_HUMAN
NC score	0.025954 (rank : 163)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	102	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q01196, O60472, O60473, O76047, O76089, Q13081, Q13755, Q13756, Q13757, Q13758, Q13759, Q15341, Q15343, Q16122, Q16284, Q16285, Q16286, Q16346, Q16347, Q92479	Gene names	RUNX1, AML1, CBFA2
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

FMN2_HUMAN
NC score	0.025397 (rank : 164)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	102	Target Neighborhood Hits	484	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

SEPT9_MOUSE
NC score	0.024561 (rank : 165)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	102	Target Neighborhood Hits	238	Shared Neighborhood Hits	7
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

ANC1_MOUSE
NC score	0.023968 (rank : 166)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	102	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P53995, Q8BP33, Q8C772	Gene names	Anapc1, Mcpr, Tsg24
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Protein Tsg24) (Mitotic checkpoint regulator).

ANC1_HUMAN
NC score	0.023964 (rank : 167)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	102	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H1A4, Q9BSE6, Q9H8D0	Gene names	ANAPC1, TSG24
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Protein Tsg24) (Mitotic checkpoint regulator).

ZCH11_HUMAN
NC score	0.022904 (rank : 168)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	102	Target Neighborhood Hits	278	Shared Neighborhood Hits	9
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

SAPS1_HUMAN
NC score	0.022849 (rank : 169)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	102	Target Neighborhood Hits	704	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

CSPG3_HUMAN
NC score	0.021487 (rank : 170)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	102	Target Neighborhood Hits	676	Shared Neighborhood Hits	8
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

K0141_HUMAN
NC score	0.020426 (rank : 171)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	102	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q14154, Q969R4, Q96EU9	Gene names	KIAA0141
Domain Architecture
Description	Protein KIAA0141.

CBP_MOUSE
NC score	0.019681 (rank : 172)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	102	Target Neighborhood Hits	1051	Shared Neighborhood Hits	25
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SHD_HUMAN
NC score	0.019604 (rank : 173)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	102	Target Neighborhood Hits	204	Shared Neighborhood Hits	7
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

MRCKG_HUMAN
NC score	0.018197 (rank : 174)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	102	Target Neighborhood Hits	1519	Shared Neighborhood Hits	27
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

IF4B_HUMAN
NC score	0.016838 (rank : 175)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	102	Target Neighborhood Hits	417	Shared Neighborhood Hits	14
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

CD2L7_HUMAN
NC score	0.015085 (rank : 176)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	102	Target Neighborhood Hits	1275	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

FA5_HUMAN
NC score	0.014430 (rank : 177)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	102	Target Neighborhood Hits	172	Shared Neighborhood Hits	8
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

ABL1_HUMAN
NC score	0.014078 (rank : 178)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	102	Target Neighborhood Hits	1220	Shared Neighborhood Hits	33
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ICK_HUMAN
NC score	0.013131 (rank : 179)	θ value	0.21417 (rank : 28)
Query Neighborhood Hits	102	Target Neighborhood Hits	867	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

TSH3_MOUSE
NC score	0.012608 (rank : 180)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	102	Target Neighborhood Hits	590	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CGV9, Q5DTX4	Gene names	Tshz3, Kiaa1474, Tsh3, Zfp537, Znf537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

K1802_MOUSE
NC score	0.012450 (rank : 181)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	102	Target Neighborhood Hits	1596	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

CTND2_HUMAN
NC score	0.012308 (rank : 182)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	102	Target Neighborhood Hits	333	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

PAX9_HUMAN
NC score	0.011688 (rank : 183)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	102	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P55771, Q99582, Q9UQR4	Gene names	PAX9
Domain Architecture
Description	Paired box protein Pax-9.

FBX46_MOUSE
NC score	0.011233 (rank : 184)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	102	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

DPOLL_MOUSE
NC score	0.011167 (rank : 185)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	102	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXE2, Q9CTJ1	Gene names	Poll, Polk
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa).

CTND2_MOUSE
NC score	0.009907 (rank : 186)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	102	Target Neighborhood Hits	227	Shared Neighborhood Hits	10
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

SN1L1_MOUSE
NC score	0.009071 (rank : 187)	θ value	1.06291 (rank : 44)
Query Neighborhood Hits	102	Target Neighborhood Hits	895	Shared Neighborhood Hits	17
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

STK6_MOUSE
NC score	0.008498 (rank : 188)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	102	Target Neighborhood Hits	886	Shared Neighborhood Hits	13
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

CHD5_HUMAN
NC score	0.008498 (rank : 189)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	102	Target Neighborhood Hits	349	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

ZO1_MOUSE
NC score	0.008201 (rank : 190)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	102	Target Neighborhood Hits	453	Shared Neighborhood Hits	14
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ICK_MOUSE
NC score	0.008121 (rank : 191)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	102	Target Neighborhood Hits	860	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

KPSH1_HUMAN
NC score	0.007951 (rank : 192)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	102	Target Neighborhood Hits	842	Shared Neighborhood Hits	12
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
NC score	0.006609 (rank : 193)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	102	Target Neighborhood Hits	839	Shared Neighborhood Hits	12
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).