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Network neighborhood for query Sequence : EHD1_HUMAN

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EHD1_HUMAN
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EHD1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
θ value	0 (rank : 2)	NC score	0.999830 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	37	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EHD2_HUMAN
θ value	0 (rank : 3)	NC score	0.997109 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	29	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD3_HUMAN
θ value	0 (rank : 4)	NC score	0.998575 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD3_MOUSE
θ value	0 (rank : 5)	NC score	0.998866 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	34	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD4_HUMAN
θ value	0 (rank : 6)	NC score	0.995492 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H223, Q9HAR1, Q9NZN2	Gene names	EHD4, HCA10, HCA11
Domain Architecture
Description	EH-domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11).

EHD4_MOUSE
θ value	0 (rank : 7)	NC score	0.996259 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	40	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

SRCA_MOUSE
θ value	6.55044e-59 (rank : 8)	NC score	0.771546 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	212	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SRCA_HUMAN
θ value	1.45929e-58 (rank : 9)	NC score	0.716162 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	380	Shared Neighborhood Hits	9
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

EP15_HUMAN
θ value	1.86321e-21 (rank : 10)	NC score	0.406831 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	1021	Shared Neighborhood Hits	27
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	4.15078e-21 (rank : 11)	NC score	0.427924 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	820	Shared Neighborhood Hits	27
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15R_HUMAN
θ value	2.69047e-20 (rank : 12)	NC score	0.352762 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	1083	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	3.51386e-20 (rank : 13)	NC score	0.358584 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	1135	Shared Neighborhood Hits	27
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

ITSN1_HUMAN
θ value	1.52774e-15 (rank : 14)	NC score	0.255049 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	1757	Shared Neighborhood Hits	27
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	4.44505e-15 (rank : 15)	NC score	0.254094 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	1669	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	1.29331e-14 (rank : 16)	NC score	0.264646 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	1173	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	1.29331e-14 (rank : 17)	NC score	0.255546 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	1371	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

REPS1_HUMAN
θ value	2.69671e-12 (rank : 18)	NC score	0.537061 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	7.84624e-12 (rank : 19)	NC score	0.532343 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	204	Shared Neighborhood Hits	20
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_MOUSE
θ value	3.08544e-08 (rank : 20)	NC score	0.524172 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	102	Shared Neighborhood Hits	19
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_HUMAN
θ value	4.0297e-08 (rank : 21)	NC score	0.506406 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

LIN1_HUMAN
θ value	0.0113563 (rank : 22)	NC score	0.085817 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	187	Shared Neighborhood Hits	10
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

APOB_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.068798 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	202	Shared Neighborhood Hits	9
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

CPSM_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.028091 (rank : 49)
Query Neighborhood Hits	36	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
θ value	1.38821 (rank : 25)	NC score	0.029655 (rank : 48)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

DRG2_MOUSE
θ value	1.38821 (rank : 26)	NC score	0.062035 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	22	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXB9	Gene names	Drg2
Domain Architecture
Description	Developmentally-regulated GTP-binding protein 2 (DRG 2).

DRG2_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.053959 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	P55039, Q9BWB2	Gene names	DRG2
Domain Architecture
Description	Developmentally-regulated GTP-binding protein 2 (DRG 2).

DESP_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.033789 (rank : 45)
Query Neighborhood Hits	36	Target Neighborhood Hits	1470	Shared Neighborhood Hits	17
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

GCC2_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.026116 (rank : 50)
Query Neighborhood Hits	36	Target Neighborhood Hits	1619	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

NUF2_MOUSE
θ value	4.03905 (rank : 30)	NC score	0.034514 (rank : 44)
Query Neighborhood Hits	36	Target Neighborhood Hits	585	Shared Neighborhood Hits	15
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

SMC2_HUMAN
θ value	4.03905 (rank : 31)	NC score	0.036891 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	1405	Shared Neighborhood Hits	17
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

MIRO1_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.010709 (rank : 51)
Query Neighborhood Hits	36	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BG51, Q3TJB7, Q3UGU4, Q5SYC3, Q5SYC6, Q8BLW3, Q8BMH1, Q922N0, Q9D2R1, Q9JKB9	Gene names	Rhot1, Arht1
Domain Architecture	No domain graphic available
Description	Mitochondrial Rho GTPase 1 (EC 3.6.5.-) (MIRO-1) (Ras homolog gene family member T1).

SYNG_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.084153 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	160	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

KNTC2_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.032415 (rank : 46)
Query Neighborhood Hits	36	Target Neighborhood Hits	673	Shared Neighborhood Hits	14
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

PLVAP_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.031130 (rank : 47)
Query Neighborhood Hits	36	Target Neighborhood Hits	210	Shared Neighborhood Hits	10
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

SYNG_MOUSE
θ value	8.99809 (rank : 36)	NC score	0.093596 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	206	Shared Neighborhood Hits	18
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

ARHG1_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.052779 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	176	Shared Neighborhood Hits	4
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.052335 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	266	Shared Neighborhood Hits	4
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG3_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.057077 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.056412 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.057564 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.056875 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGB_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.051400 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	375	Shared Neighborhood Hits	6
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.050428 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	214	Shared Neighborhood Hits	5
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.055158 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.057299 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NCF1_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.050798 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NGEF_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.051510 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	166	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.052126 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RGNEF_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.051568 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	641	Shared Neighborhood Hits	10
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SH3K1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.053889 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	341	Shared Neighborhood Hits	6
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

Hits sorted by NC score

EHD1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
NC score	0.999830 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	37	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EHD3_MOUSE
NC score	0.998866 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	34	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD3_HUMAN
NC score	0.998575 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD2_HUMAN
NC score	0.997109 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	29	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD4_MOUSE
NC score	0.996259 (rank : 6)	θ value	0 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	40	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

EHD4_HUMAN
NC score	0.995492 (rank : 7)	θ value	0 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H223, Q9HAR1, Q9NZN2	Gene names	EHD4, HCA10, HCA11
Domain Architecture
Description	EH-domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11).

SRCA_MOUSE
NC score	0.771546 (rank : 8)	θ value	6.55044e-59 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	212	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SRCA_HUMAN
NC score	0.716162 (rank : 9)	θ value	1.45929e-58 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	380	Shared Neighborhood Hits	9
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

REPS1_HUMAN
NC score	0.537061 (rank : 10)	θ value	2.69671e-12 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
NC score	0.532343 (rank : 11)	θ value	7.84624e-12 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	204	Shared Neighborhood Hits	20
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_MOUSE
NC score	0.524172 (rank : 12)	θ value	3.08544e-08 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	102	Shared Neighborhood Hits	19
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_HUMAN
NC score	0.506406 (rank : 13)	θ value	4.0297e-08 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

EP15_MOUSE
NC score	0.427924 (rank : 14)	θ value	4.15078e-21 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	820	Shared Neighborhood Hits	27
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_HUMAN
NC score	0.406831 (rank : 15)	θ value	1.86321e-21 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	1021	Shared Neighborhood Hits	27
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15R_MOUSE
NC score	0.358584 (rank : 16)	θ value	3.51386e-20 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	1135	Shared Neighborhood Hits	27
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15R_HUMAN
NC score	0.352762 (rank : 17)	θ value	2.69047e-20 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	1083	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

ITSN2_HUMAN
NC score	0.264646 (rank : 18)	θ value	1.29331e-14 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	1173	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
NC score	0.255546 (rank : 19)	θ value	1.29331e-14 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	1371	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.255049 (rank : 20)	θ value	1.52774e-15 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	1757	Shared Neighborhood Hits	27
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.254094 (rank : 21)	θ value	4.44505e-15 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	1669	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SYNG_MOUSE
NC score	0.093596 (rank : 22)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	206	Shared Neighborhood Hits	18
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

LIN1_HUMAN
NC score	0.085817 (rank : 23)	θ value	0.0113563 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	187	Shared Neighborhood Hits	10
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

SYNG_HUMAN
NC score	0.084153 (rank : 24)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	160	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

APOB_HUMAN
NC score	0.068798 (rank : 25)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	202	Shared Neighborhood Hits	9
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

DRG2_MOUSE
NC score	0.062035 (rank : 26)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	22	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXB9	Gene names	Drg2
Domain Architecture
Description	Developmentally-regulated GTP-binding protein 2 (DRG 2).

ARHG8_HUMAN
NC score	0.057564 (rank : 27)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGG_MOUSE
NC score	0.057299 (rank : 28)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	36	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG3_HUMAN
NC score	0.057077 (rank : 29)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG8_MOUSE
NC score	0.056875 (rank : 30)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG3_MOUSE
NC score	0.056412 (rank : 31)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHGG_HUMAN
NC score	0.055158 (rank : 32)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	36	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DRG2_HUMAN
NC score	0.053959 (rank : 33)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	P55039, Q9BWB2	Gene names	DRG2
Domain Architecture
Description	Developmentally-regulated GTP-binding protein 2 (DRG 2).

SH3K1_HUMAN
NC score	0.053889 (rank : 34)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	36	Target Neighborhood Hits	341	Shared Neighborhood Hits	6
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ARHG1_HUMAN
NC score	0.052779 (rank : 35)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	176	Shared Neighborhood Hits	4
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.052335 (rank : 36)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	266	Shared Neighborhood Hits	4
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

NGEF_MOUSE
NC score	0.052126 (rank : 37)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	36	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RGNEF_MOUSE
NC score	0.051568 (rank : 38)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	36	Target Neighborhood Hits	641	Shared Neighborhood Hits	10
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

NGEF_HUMAN
NC score	0.051510 (rank : 39)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	36	Target Neighborhood Hits	166	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGB_HUMAN
NC score	0.051400 (rank : 40)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	375	Shared Neighborhood Hits	6
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

NCF1_MOUSE
NC score	0.050798 (rank : 41)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	36	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ARHGF_HUMAN
NC score	0.050428 (rank : 42)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	36	Target Neighborhood Hits	214	Shared Neighborhood Hits	5
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

SMC2_HUMAN
NC score	0.036891 (rank : 43)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	1405	Shared Neighborhood Hits	17
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

NUF2_MOUSE
NC score	0.034514 (rank : 44)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	585	Shared Neighborhood Hits	15
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

DESP_HUMAN
NC score	0.033789 (rank : 45)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	1470	Shared Neighborhood Hits	17
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

KNTC2_HUMAN
NC score	0.032415 (rank : 46)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	673	Shared Neighborhood Hits	14
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

PLVAP_MOUSE
NC score	0.031130 (rank : 47)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	210	Shared Neighborhood Hits	10
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

CPSM_MOUSE
NC score	0.029655 (rank : 48)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_HUMAN
NC score	0.028091 (rank : 49)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

GCC2_MOUSE
NC score	0.026116 (rank : 50)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	1619	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

MIRO1_MOUSE
NC score	0.010709 (rank : 51)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BG51, Q3TJB7, Q3UGU4, Q5SYC3, Q5SYC6, Q8BLW3, Q8BMH1, Q922N0, Q9D2R1, Q9JKB9	Gene names	Rhot1, Arht1
Domain Architecture	No domain graphic available
Description	Mitochondrial Rho GTPase 1 (EC 3.6.5.-) (MIRO-1) (Ras homolog gene family member T1).