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Network neighborhood for query Sequence : ARHGG_HUMAN

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ARHGG_HUMAN
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARHGG_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	129	Target Neighborhood Hits	129	Shared Neighborhood Hits	129
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	0 (rank : 2)	NC score	0.988458 (rank : 2)
Query Neighborhood Hits	129	Target Neighborhood Hits	152	Shared Neighborhood Hits	101
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_MOUSE
θ value	3.93732e-88 (rank : 3)	NC score	0.915839 (rank : 5)
Query Neighborhood Hits	129	Target Neighborhood Hits	228	Shared Neighborhood Hits	97
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
θ value	1.49618e-87 (rank : 4)	NC score	0.921373 (rank : 4)
Query Neighborhood Hits	129	Target Neighborhood Hits	166	Shared Neighborhood Hits	95
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG5_HUMAN
θ value	4.36332e-79 (rank : 5)	NC score	0.924523 (rank : 3)
Query Neighborhood Hits	129	Target Neighborhood Hits	172	Shared Neighborhood Hits	97
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGF_HUMAN
θ value	2.03627e-60 (rank : 6)	NC score	0.879263 (rank : 6)
Query Neighborhood Hits	129	Target Neighborhood Hits	214	Shared Neighborhood Hits	64
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ITSN2_HUMAN
θ value	8.93572e-24 (rank : 7)	NC score	0.523382 (rank : 40)
Query Neighborhood Hits	129	Target Neighborhood Hits	1173	Shared Neighborhood Hits	108
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_HUMAN
θ value	1.16704e-23 (rank : 8)	NC score	0.481907 (rank : 49)
Query Neighborhood Hits	129	Target Neighborhood Hits	1757	Shared Neighborhood Hits	110
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	1.99067e-23 (rank : 9)	NC score	0.481919 (rank : 48)
Query Neighborhood Hits	129	Target Neighborhood Hits	1669	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_MOUSE
θ value	2.20094e-22 (rank : 10)	NC score	0.497251 (rank : 43)
Query Neighborhood Hits	129	Target Neighborhood Hits	1371	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

FGD4_MOUSE
θ value	3.88503e-19 (rank : 11)	NC score	0.654487 (rank : 19)
Query Neighborhood Hits	129	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
θ value	1.92812e-18 (rank : 12)	NC score	0.656941 (rank : 18)
Query Neighborhood Hits	129	Target Neighborhood Hits	219	Shared Neighborhood Hits	70
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHGC_HUMAN
θ value	2.60593e-15 (rank : 13)	NC score	0.642912 (rank : 20)
Query Neighborhood Hits	129	Target Neighborhood Hits	351	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	9.90251e-15 (rank : 14)	NC score	0.641083 (rank : 22)
Query Neighborhood Hits	129	Target Neighborhood Hits	344	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG8_MOUSE
θ value	8.38298e-14 (rank : 15)	NC score	0.677409 (rank : 12)
Query Neighborhood Hits	129	Target Neighborhood Hits	79	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

FGD1_HUMAN
θ value	1.09485e-13 (rank : 16)	NC score	0.623624 (rank : 30)
Query Neighborhood Hits	129	Target Neighborhood Hits	367	Shared Neighborhood Hits	68
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGB_HUMAN
θ value	1.86753e-13 (rank : 17)	NC score	0.659218 (rank : 16)
Query Neighborhood Hits	129	Target Neighborhood Hits	375	Shared Neighborhood Hits	70
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG1_HUMAN
θ value	5.43371e-13 (rank : 18)	NC score	0.689688 (rank : 8)
Query Neighborhood Hits	129	Target Neighborhood Hits	176	Shared Neighborhood Hits	62
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG8_HUMAN
θ value	7.09661e-13 (rank : 19)	NC score	0.692352 (rank : 7)
Query Neighborhood Hits	129	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FGD1_MOUSE
θ value	9.26847e-13 (rank : 20)	NC score	0.623025 (rank : 31)
Query Neighborhood Hits	129	Target Neighborhood Hits	387	Shared Neighborhood Hits	68
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

PREX1_HUMAN
θ value	9.26847e-13 (rank : 21)	NC score	0.661398 (rank : 15)
Query Neighborhood Hits	129	Target Neighborhood Hits	177	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG2_MOUSE
θ value	2.69671e-12 (rank : 22)	NC score	0.671810 (rank : 13)
Query Neighborhood Hits	129	Target Neighborhood Hits	120	Shared Neighborhood Hits	65
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	2.69671e-12 (rank : 23)	NC score	0.687621 (rank : 9)
Query Neighborhood Hits	129	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG4_HUMAN
θ value	2.69671e-12 (rank : 24)	NC score	0.627414 (rank : 29)
Query Neighborhood Hits	129	Target Neighborhood Hits	242	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG1_MOUSE
θ value	4.59992e-12 (rank : 25)	NC score	0.658485 (rank : 17)
Query Neighborhood Hits	129	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

PKHG1_HUMAN
θ value	2.28291e-11 (rank : 26)	NC score	0.636236 (rank : 24)
Query Neighborhood Hits	129	Target Neighborhood Hits	174	Shared Neighborhood Hits	67
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG3_MOUSE
θ value	2.98157e-11 (rank : 27)	NC score	0.684073 (rank : 10)
Query Neighborhood Hits	129	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

VAV2_MOUSE
θ value	2.98157e-11 (rank : 28)	NC score	0.494874 (rank : 45)
Query Neighborhood Hits	129	Target Neighborhood Hits	456	Shared Neighborhood Hits	91
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FGD2_MOUSE
θ value	3.89403e-11 (rank : 29)	NC score	0.633726 (rank : 26)
Query Neighborhood Hits	129	Target Neighborhood Hits	163	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

VAV2_HUMAN
θ value	3.89403e-11 (rank : 30)	NC score	0.498162 (rank : 42)
Query Neighborhood Hits	129	Target Neighborhood Hits	453	Shared Neighborhood Hits	90
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

TIAM1_MOUSE
θ value	6.64225e-11 (rank : 31)	NC score	0.622988 (rank : 32)
Query Neighborhood Hits	129	Target Neighborhood Hits	205	Shared Neighborhood Hits	70
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

LBC_HUMAN
θ value	8.67504e-11 (rank : 32)	NC score	0.629764 (rank : 28)
Query Neighborhood Hits	129	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_HUMAN
θ value	1.133e-10 (rank : 33)	NC score	0.638909 (rank : 23)
Query Neighborhood Hits	129	Target Neighborhood Hits	142	Shared Neighborhood Hits	62
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

RGNEF_MOUSE
θ value	1.9326e-10 (rank : 34)	NC score	0.553369 (rank : 37)
Query Neighborhood Hits	129	Target Neighborhood Hits	641	Shared Neighborhood Hits	69
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG9_MOUSE
θ value	2.52405e-10 (rank : 35)	NC score	0.619484 (rank : 34)
Query Neighborhood Hits	129	Target Neighborhood Hits	234	Shared Neighborhood Hits	88
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
θ value	3.29651e-10 (rank : 36)	NC score	0.619212 (rank : 35)
Query Neighborhood Hits	129	Target Neighborhood Hits	235	Shared Neighborhood Hits	90
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

FARP2_MOUSE
θ value	3.29651e-10 (rank : 37)	NC score	0.445598 (rank : 55)
Query Neighborhood Hits	129	Target Neighborhood Hits	209	Shared Neighborhood Hits	68
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG4_MOUSE
θ value	5.62301e-10 (rank : 38)	NC score	0.634121 (rank : 25)
Query Neighborhood Hits	129	Target Neighborhood Hits	185	Shared Neighborhood Hits	81
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD2_HUMAN
θ value	5.62301e-10 (rank : 39)	NC score	0.632093 (rank : 27)
Query Neighborhood Hits	129	Target Neighborhood Hits	151	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ECT2_HUMAN
θ value	9.59137e-10 (rank : 40)	NC score	0.668138 (rank : 14)
Query Neighborhood Hits	129	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP2_HUMAN
θ value	1.25267e-09 (rank : 41)	NC score	0.412503 (rank : 62)
Query Neighborhood Hits	129	Target Neighborhood Hits	240	Shared Neighborhood Hits	62
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

TIAM1_HUMAN
θ value	1.63604e-09 (rank : 42)	NC score	0.609959 (rank : 36)
Query Neighborhood Hits	129	Target Neighborhood Hits	225	Shared Neighborhood Hits	70
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ECT2_MOUSE
θ value	2.79066e-09 (rank : 43)	NC score	0.677990 (rank : 11)
Query Neighborhood Hits	129	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD3_MOUSE
θ value	6.21693e-09 (rank : 44)	NC score	0.641181 (rank : 21)
Query Neighborhood Hits	129	Target Neighborhood Hits	257	Shared Neighborhood Hits	69
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

VAV_HUMAN
θ value	1.06045e-08 (rank : 45)	NC score	0.473941 (rank : 53)
Query Neighborhood Hits	129	Target Neighborhood Hits	452	Shared Neighborhood Hits	97
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

FGD6_MOUSE
θ value	1.38499e-08 (rank : 46)	NC score	0.551310 (rank : 38)
Query Neighborhood Hits	129	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

DUET_HUMAN
θ value	4.0297e-08 (rank : 47)	NC score	0.191717 (rank : 82)
Query Neighborhood Hits	129	Target Neighborhood Hits	1220	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

FGD3_HUMAN
θ value	4.0297e-08 (rank : 48)	NC score	0.621317 (rank : 33)
Query Neighborhood Hits	129	Target Neighborhood Hits	249	Shared Neighborhood Hits	67
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD6_HUMAN
θ value	6.87365e-08 (rank : 49)	NC score	0.548788 (rank : 39)
Query Neighborhood Hits	129	Target Neighborhood Hits	237	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FARP1_HUMAN
θ value	1.53129e-07 (rank : 50)	NC score	0.390993 (rank : 65)
Query Neighborhood Hits	129	Target Neighborhood Hits	241	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FGD5_MOUSE
θ value	3.41135e-07 (rank : 51)	NC score	0.411149 (rank : 64)
Query Neighborhood Hits	129	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

VAV_MOUSE
θ value	4.45536e-07 (rank : 52)	NC score	0.482539 (rank : 47)
Query Neighborhood Hits	129	Target Neighborhood Hits	430	Shared Neighborhood Hits	97
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GNRP_MOUSE
θ value	9.92553e-07 (rank : 53)	NC score	0.475221 (rank : 51)
Query Neighborhood Hits	129	Target Neighborhood Hits	191	Shared Neighborhood Hits	58
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
θ value	1.29631e-06 (rank : 54)	NC score	0.441077 (rank : 56)
Query Neighborhood Hits	129	Target Neighborhood Hits	239	Shared Neighborhood Hits	56
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

FGD5_HUMAN
θ value	1.69304e-06 (rank : 55)	NC score	0.423543 (rank : 60)
Query Neighborhood Hits	129	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

TRIO_HUMAN
θ value	2.88788e-06 (rank : 56)	NC score	0.175179 (rank : 88)
Query Neighborhood Hits	129	Target Neighborhood Hits	1580	Shared Neighborhood Hits	88
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

HAPIP_HUMAN
θ value	8.40245e-06 (rank : 57)	NC score	0.438907 (rank : 57)
Query Neighborhood Hits	129	Target Neighborhood Hits	350	Shared Neighborhood Hits	72
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

DNMBP_HUMAN
θ value	2.44474e-05 (rank : 58)	NC score	0.478251 (rank : 50)
Query Neighborhood Hits	129	Target Neighborhood Hits	413	Shared Neighborhood Hits	98
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ABR_HUMAN
θ value	9.29e-05 (rank : 59)	NC score	0.334225 (rank : 70)
Query Neighborhood Hits	129	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

MCF2_HUMAN
θ value	0.000158464 (rank : 60)	NC score	0.519399 (rank : 41)
Query Neighborhood Hits	129	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

VAV3_MOUSE
θ value	0.00035302 (rank : 61)	NC score	0.433372 (rank : 58)
Query Neighborhood Hits	129	Target Neighborhood Hits	404	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

DNMBP_MOUSE
θ value	0.000602161 (rank : 62)	NC score	0.497220 (rank : 44)
Query Neighborhood Hits	129	Target Neighborhood Hits	435	Shared Neighborhood Hits	96
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MCF2L_MOUSE
θ value	0.000602161 (rank : 63)	NC score	0.491509 (rank : 46)
Query Neighborhood Hits	129	Target Neighborhood Hits	255	Shared Neighborhood Hits	68
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

LASP1_HUMAN
θ value	0.00175202 (rank : 64)	NC score	0.173424 (rank : 92)
Query Neighborhood Hits	129	Target Neighborhood Hits	293	Shared Neighborhood Hits	52
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00175202 (rank : 65)	NC score	0.171628 (rank : 94)
Query Neighborhood Hits	129	Target Neighborhood Hits	297	Shared Neighborhood Hits	52
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

VAV3_HUMAN
θ value	0.00228821 (rank : 66)	NC score	0.426727 (rank : 59)
Query Neighborhood Hits	129	Target Neighborhood Hits	398	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

AMPH_HUMAN
θ value	0.00390308 (rank : 67)	NC score	0.131125 (rank : 109)
Query Neighborhood Hits	129	Target Neighborhood Hits	455	Shared Neighborhood Hits	39
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

NEBL_HUMAN
θ value	0.00509761 (rank : 68)	NC score	0.144861 (rank : 99)
Query Neighborhood Hits	129	Target Neighborhood Hits	457	Shared Neighborhood Hits	51
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

BCR_HUMAN
θ value	0.0113563 (rank : 69)	NC score	0.335339 (rank : 69)
Query Neighborhood Hits	129	Target Neighborhood Hits	204	Shared Neighborhood Hits	61
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

AMPH_MOUSE
θ value	0.0148317 (rank : 70)	NC score	0.123492 (rank : 117)
Query Neighborhood Hits	129	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BI2L1_MOUSE
θ value	0.0252991 (rank : 71)	NC score	0.176200 (rank : 86)
Query Neighborhood Hits	129	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_HUMAN
θ value	0.0330416 (rank : 72)	NC score	0.196429 (rank : 79)
Query Neighborhood Hits	129	Target Neighborhood Hits	156	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

TCGAP_MOUSE
θ value	0.0431538 (rank : 73)	NC score	0.108792 (rank : 139)
Query Neighborhood Hits	129	Target Neighborhood Hits	409	Shared Neighborhood Hits	50
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ARHG6_HUMAN
θ value	0.0736092 (rank : 74)	NC score	0.383356 (rank : 66)
Query Neighborhood Hits	129	Target Neighborhood Hits	376	Shared Neighborhood Hits	86
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SH3K1_MOUSE
θ value	0.0736092 (rank : 75)	NC score	0.214603 (rank : 72)
Query Neighborhood Hits	129	Target Neighborhood Hits	332	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

BAIP2_HUMAN
θ value	0.125558 (rank : 76)	NC score	0.151811 (rank : 98)
Query Neighborhood Hits	129	Target Neighborhood Hits	192	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	0.125558 (rank : 77)	NC score	0.152408 (rank : 97)
Query Neighborhood Hits	129	Target Neighborhood Hits	185	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

ARHG7_MOUSE
θ value	0.21417 (rank : 78)	NC score	0.411822 (rank : 63)
Query Neighborhood Hits	129	Target Neighborhood Hits	396	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

SH3K1_HUMAN
θ value	0.21417 (rank : 79)	NC score	0.223543 (rank : 71)
Query Neighborhood Hits	129	Target Neighborhood Hits	341	Shared Neighborhood Hits	56
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ARHG6_MOUSE
θ value	0.365318 (rank : 80)	NC score	0.368320 (rank : 67)
Query Neighborhood Hits	129	Target Neighborhood Hits	394	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

NCK2_HUMAN
θ value	0.365318 (rank : 81)	NC score	0.173215 (rank : 93)
Query Neighborhood Hits	129	Target Neighborhood Hits	310	Shared Neighborhood Hits	50
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

AHI1_MOUSE
θ value	0.47712 (rank : 82)	NC score	0.126969 (rank : 111)
Query Neighborhood Hits	129	Target Neighborhood Hits	496	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG7_HUMAN
θ value	0.47712 (rank : 83)	NC score	0.414778 (rank : 61)
Query Neighborhood Hits	129	Target Neighborhood Hits	347	Shared Neighborhood Hits	92
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

NCK1_HUMAN
θ value	0.47712 (rank : 84)	NC score	0.175255 (rank : 87)
Query Neighborhood Hits	129	Target Neighborhood Hits	312	Shared Neighborhood Hits	57
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SRBS1_HUMAN
θ value	0.47712 (rank : 85)	NC score	0.206125 (rank : 76)
Query Neighborhood Hits	129	Target Neighborhood Hits	396	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	0.47712 (rank : 86)	NC score	0.212476 (rank : 73)
Query Neighborhood Hits	129	Target Neighborhood Hits	409	Shared Neighborhood Hits	54
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF2_HUMAN
θ value	0.62314 (rank : 87)	NC score	0.205784 (rank : 77)
Query Neighborhood Hits	129	Target Neighborhood Hits	229	Shared Neighborhood Hits	52
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ZN546_HUMAN
θ value	0.62314 (rank : 88)	NC score	-0.004321 (rank : 287)
Query Neighborhood Hits	129	Target Neighborhood Hits	772	Shared Neighborhood Hits	4
SwissProt Accessions	Q86UE3	Gene names	ZNF546, ZNF49
Domain Architecture	No domain graphic available
Description	Zinc finger protein 546.

BIN1_HUMAN
θ value	0.813845 (rank : 89)	NC score	0.122003 (rank : 120)
Query Neighborhood Hits	129	Target Neighborhood Hits	335	Shared Neighborhood Hits	40
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	0.813845 (rank : 90)	NC score	0.126532 (rank : 113)
Query Neighborhood Hits	129	Target Neighborhood Hits	283	Shared Neighborhood Hits	42
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

GOGA2_MOUSE
θ value	0.813845 (rank : 91)	NC score	0.023081 (rank : 266)
Query Neighborhood Hits	129	Target Neighborhood Hits	944	Shared Neighborhood Hits	20
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

NEBU_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.121824 (rank : 122)
Query Neighborhood Hits	129	Target Neighborhood Hits	420	Shared Neighborhood Hits	55
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

CD2AP_HUMAN
θ value	1.06291 (rank : 93)	NC score	0.209829 (rank : 74)
Query Neighborhood Hits	129	Target Neighborhood Hits	315	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	1.06291 (rank : 94)	NC score	0.208632 (rank : 75)
Query Neighborhood Hits	129	Target Neighborhood Hits	336	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

DOCK1_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.064915 (rank : 208)
Query Neighborhood Hits	129	Target Neighborhood Hits	191	Shared Neighborhood Hits	42
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

2A5D_HUMAN
θ value	1.38821 (rank : 96)	NC score	0.018766 (rank : 268)
Query Neighborhood Hits	129	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	Q14738, O00494, O00696, Q15171	Gene names	PPP2R5D
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (PP2A, B subunit, B56 delta isoform) (PP2A, B subunit, PR61 delta isoform) (PP2A, B subunit, R5 delta isoform).

FOXN4_MOUSE
θ value	1.38821 (rank : 97)	NC score	0.008120 (rank : 280)
Query Neighborhood Hits	129	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K3Q3, Q920C0	Gene names	Foxn4
Domain Architecture
Description	Forkhead box protein N4.

AHI1_HUMAN
θ value	2.36792 (rank : 98)	NC score	0.126610 (rank : 112)
Query Neighborhood Hits	129	Target Neighborhood Hits	537	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ANGP2_MOUSE
θ value	2.36792 (rank : 99)	NC score	0.003700 (rank : 284)
Query Neighborhood Hits	129	Target Neighborhood Hits	397	Shared Neighborhood Hits	6
SwissProt Accessions	O35608, Q3U1A1, Q9D2D2	Gene names	Angpt2, Agpt2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

RGS3_HUMAN
θ value	2.36792 (rank : 100)	NC score	0.026372 (rank : 263)
Query Neighborhood Hits	129	Target Neighborhood Hits	1375	Shared Neighborhood Hits	27
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

VINEX_HUMAN
θ value	2.36792 (rank : 101)	NC score	0.191802 (rank : 81)
Query Neighborhood Hits	129	Target Neighborhood Hits	270	Shared Neighborhood Hits	54
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	2.36792 (rank : 102)	NC score	0.186662 (rank : 84)
Query Neighborhood Hits	129	Target Neighborhood Hits	286	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

AXN2_MOUSE
θ value	3.0926 (rank : 103)	NC score	0.009874 (rank : 276)
Query Neighborhood Hits	129	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

CENPJ_HUMAN
θ value	3.0926 (rank : 104)	NC score	0.029380 (rank : 262)
Query Neighborhood Hits	129	Target Neighborhood Hits	721	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

CAN7_MOUSE
θ value	4.03905 (rank : 105)	NC score	0.017588 (rank : 269)
Query Neighborhood Hits	129	Target Neighborhood Hits	66	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1S8, Q9Z0P9	Gene names	Capn7, Palbh
Domain Architecture
Description	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH).

RASA1_HUMAN
θ value	4.03905 (rank : 106)	NC score	0.035825 (rank : 261)
Query Neighborhood Hits	129	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

DDEF2_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.075444 (rank : 188)
Query Neighborhood Hits	129	Target Neighborhood Hits	599	Shared Neighborhood Hits	58
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DYNA_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.015569 (rank : 270)
Query Neighborhood Hits	129	Target Neighborhood Hits	1194	Shared Neighborhood Hits	23
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

HAP1_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.009731 (rank : 278)
Query Neighborhood Hits	129	Target Neighborhood Hits	388	Shared Neighborhood Hits	12
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

HOOK1_HUMAN
θ value	5.27518 (rank : 110)	NC score	0.023145 (rank : 265)
Query Neighborhood Hits	129	Target Neighborhood Hits	942	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

HOOK1_MOUSE
θ value	5.27518 (rank : 111)	NC score	0.021135 (rank : 267)
Query Neighborhood Hits	129	Target Neighborhood Hits	910	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

IQEC1_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.012457 (rank : 274)
Query Neighborhood Hits	129	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

K0056_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.009765 (rank : 277)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

SHAN1_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.076246 (rank : 185)
Query Neighborhood Hits	129	Target Neighborhood Hits	1041	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

2A5G_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.013175 (rank : 272)
Query Neighborhood Hits	129	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q13362, Q14391, Q15060, Q15174	Gene names	PPP2R5C, KIAA0044
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (NY-REN-29 antigen).

2A5G_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.013183 (rank : 271)
Query Neighborhood Hits	129	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q60996, O35708, Q99KW8, Q99N67, Q99N68	Gene names	Ppp2r5c
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (PP2A, B subunit, B'alpha3 isoform).

CA026_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.008797 (rank : 279)
Query Neighborhood Hits	129	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T5J6, Q8NEK9, Q9BZQ7, Q9NXQ0	Gene names	C1orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf26.

DOC10_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.006313 (rank : 281)
Query Neighborhood Hits	129	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

E2AK4_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.002052 (rank : 285)
Query Neighborhood Hits	129	Target Neighborhood Hits	1012	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

PKHG4_HUMAN
θ value	6.88961 (rank : 120)	NC score	0.339099 (rank : 68)
Query Neighborhood Hits	129	Target Neighborhood Hits	200	Shared Neighborhood Hits	54
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SYNG_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.044990 (rank : 260)
Query Neighborhood Hits	129	Target Neighborhood Hits	160	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

MINK1_HUMAN
θ value	8.99809 (rank : 122)	NC score	0.004796 (rank : 282)
Query Neighborhood Hits	129	Target Neighborhood Hits	1477	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	8.99809 (rank : 123)	NC score	0.003904 (rank : 283)
Query Neighborhood Hits	129	Target Neighborhood Hits	1451	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

PCOC1_HUMAN
θ value	8.99809 (rank : 124)	NC score	0.001564 (rank : 286)
Query Neighborhood Hits	129	Target Neighborhood Hits	146	Shared Neighborhood Hits	3
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

POF1B_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.013128 (rank : 273)
Query Neighborhood Hits	129	Target Neighborhood Hits	494	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

SF3B2_HUMAN
θ value	8.99809 (rank : 126)	NC score	0.011053 (rank : 275)
Query Neighborhood Hits	129	Target Neighborhood Hits	157	Shared Neighborhood Hits	3
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

STS1_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.076523 (rank : 184)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	8.99809 (rank : 128)	NC score	0.075706 (rank : 187)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

TRIPB_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.023818 (rank : 264)
Query Neighborhood Hits	129	Target Neighborhood Hits	1587	Shared Neighborhood Hits	39
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ABI1_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.124920 (rank : 114)
Query Neighborhood Hits	129	Target Neighborhood Hits	257	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.134974 (rank : 105)
Query Neighborhood Hits	129	Target Neighborhood Hits	246	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.135813 (rank : 104)
Query Neighborhood Hits	129	Target Neighborhood Hits	350	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.136494 (rank : 103)
Query Neighborhood Hits	129	Target Neighborhood Hits	266	Shared Neighborhood Hits	49
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.115555 (rank : 130)
Query Neighborhood Hits	129	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.115218 (rank : 132)
Query Neighborhood Hits	129	Target Neighborhood Hits	227	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ANM2_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.081061 (rank : 175)
Query Neighborhood Hits	129	Target Neighborhood Hits	175	Shared Neighborhood Hits	36
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.076155 (rank : 186)
Query Neighborhood Hits	129	Target Neighborhood Hits	175	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHGA_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.474836 (rank : 52)
Query Neighborhood Hits	129	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.452470 (rank : 54)
Query Neighborhood Hits	129	Target Neighborhood Hits	125	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ASPP1_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.053885 (rank : 244)
Query Neighborhood Hits	129	Target Neighborhood Hits	956	Shared Neighborhood Hits	50
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.057061 (rank : 235)
Query Neighborhood Hits	129	Target Neighborhood Hits	1244	Shared Neighborhood Hits	54
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.073218 (rank : 192)
Query Neighborhood Hits	129	Target Neighborhood Hits	554	Shared Neighborhood Hits	42
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.078194 (rank : 180)
Query Neighborhood Hits	129	Target Neighborhood Hits	438	Shared Neighborhood Hits	43
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.072435 (rank : 195)
Query Neighborhood Hits	129	Target Neighborhood Hits	259	Shared Neighborhood Hits	39
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.068060 (rank : 200)
Query Neighborhood Hits	129	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CRKL_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.105887 (rank : 146)
Query Neighborhood Hits	129	Target Neighborhood Hits	313	Shared Neighborhood Hits	42
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.102995 (rank : 147)
Query Neighborhood Hits	129	Target Neighborhood Hits	307	Shared Neighborhood Hits	41
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.095182 (rank : 159)
Query Neighborhood Hits	129	Target Neighborhood Hits	308	Shared Neighborhood Hits	43
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.098542 (rank : 153)
Query Neighborhood Hits	129	Target Neighborhood Hits	314	Shared Neighborhood Hits	44
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.074008 (rank : 189)
Query Neighborhood Hits	129	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.101614 (rank : 151)
Query Neighborhood Hits	129	Target Neighborhood Hits	244	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.096667 (rank : 155)
Query Neighborhood Hits	129	Target Neighborhood Hits	306	Shared Neighborhood Hits	39
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.066859 (rank : 204)
Query Neighborhood Hits	129	Target Neighborhood Hits	592	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.072829 (rank : 194)
Query Neighborhood Hits	129	Target Neighborhood Hits	625	Shared Neighborhood Hits	54
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EEA1_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.051381 (rank : 255)
Query Neighborhood Hits	129	Target Neighborhood Hits	1796	Shared Neighborhood Hits	42
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.051714 (rank : 254)
Query Neighborhood Hits	129	Target Neighborhood Hits	1637	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.070036 (rank : 197)
Query Neighborhood Hits	129	Target Neighborhood Hits	348	Shared Neighborhood Hits	40
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.078140 (rank : 181)
Query Neighborhood Hits	129	Target Neighborhood Hits	389	Shared Neighborhood Hits	43
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EHD1_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.055158 (rank : 238)
Query Neighborhood Hits	129	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.055067 (rank : 239)
Query Neighborhood Hits	129	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EHD2_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.054465 (rank : 241)
Query Neighborhood Hits	129	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD3_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.054424 (rank : 242)
Query Neighborhood Hits	129	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD3_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.053985 (rank : 243)
Query Neighborhood Hits	129	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD4_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.050696 (rank : 256)
Query Neighborhood Hits	129	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H223, Q9HAR1, Q9NZN2	Gene names	EHD4, HCA10, HCA11
Domain Architecture
Description	EH-domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11).

EHD4_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.053817 (rank : 245)
Query Neighborhood Hits	129	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

EP15R_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.050103 (rank : 259)
Query Neighborhood Hits	129	Target Neighborhood Hits	1083	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.053328 (rank : 248)
Query Neighborhood Hits	129	Target Neighborhood Hits	1135	Shared Neighborhood Hits	21
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.051749 (rank : 253)
Query Neighborhood Hits	129	Target Neighborhood Hits	1021	Shared Neighborhood Hits	22
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.054525 (rank : 240)
Query Neighborhood Hits	129	Target Neighborhood Hits	820	Shared Neighborhood Hits	21
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

ES8L3_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.050379 (rank : 257)
Query Neighborhood Hits	129	Target Neighborhood Hits	168	Shared Neighborhood Hits	34
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FNBP2_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.063668 (rank : 211)
Query Neighborhood Hits	129	Target Neighborhood Hits	432	Shared Neighborhood Hits	42
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYV1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.059950 (rank : 225)
Query Neighborhood Hits	129	Target Neighborhood Hits	217	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.058454 (rank : 232)
Query Neighborhood Hits	129	Target Neighborhood Hits	191	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GRAP2_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.111021 (rank : 137)
Query Neighborhood Hits	129	Target Neighborhood Hits	304	Shared Neighborhood Hits	45
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.111461 (rank : 136)
Query Neighborhood Hits	129	Target Neighborhood Hits	297	Shared Neighborhood Hits	46
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.134047 (rank : 106)
Query Neighborhood Hits	129	Target Neighborhood Hits	307	Shared Neighborhood Hits	47
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.133217 (rank : 107)
Query Neighborhood Hits	129	Target Neighborhood Hits	309	Shared Neighborhood Hits	48
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.120631 (rank : 124)
Query Neighborhood Hits	129	Target Neighborhood Hits	310	Shared Neighborhood Hits	47
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.120487 (rank : 125)
Query Neighborhood Hits	129	Target Neighborhood Hits	312	Shared Neighborhood Hits	47
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.050323 (rank : 258)
Query Neighborhood Hits	129	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.119086 (rank : 126)
Query Neighborhood Hits	129	Target Neighborhood Hits	358	Shared Neighborhood Hits	46
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.121353 (rank : 123)
Query Neighborhood Hits	129	Target Neighborhood Hits	329	Shared Neighborhood Hits	44
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.084971 (rank : 172)
Query Neighborhood Hits	129	Target Neighborhood Hits	517	Shared Neighborhood Hits	23
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.085016 (rank : 171)
Query Neighborhood Hits	129	Target Neighborhood Hits	589	Shared Neighborhood Hits	23
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IASPP_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.062728 (rank : 216)
Query Neighborhood Hits	129	Target Neighborhood Hits	688	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.060934 (rank : 223)
Query Neighborhood Hits	129	Target Neighborhood Hits	1024	Shared Neighborhood Hits	48
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

JIP2_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.073795 (rank : 191)
Query Neighborhood Hits	129	Target Neighborhood Hits	288	Shared Neighborhood Hits	30
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.073027 (rank : 193)
Query Neighborhood Hits	129	Target Neighborhood Hits	144	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MYO1E_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.060565 (rank : 224)
Query Neighborhood Hits	129	Target Neighborhood Hits	293	Shared Neighborhood Hits	51
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.058333 (rank : 233)
Query Neighborhood Hits	129	Target Neighborhood Hits	275	Shared Neighborhood Hits	44
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.058971 (rank : 230)
Query Neighborhood Hits	129	Target Neighborhood Hits	262	Shared Neighborhood Hits	44
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.192220 (rank : 80)
Query Neighborhood Hits	129	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.189264 (rank : 83)
Query Neighborhood Hits	129	Target Neighborhood Hits	198	Shared Neighborhood Hits	49
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.138703 (rank : 101)
Query Neighborhood Hits	129	Target Neighborhood Hits	161	Shared Neighborhood Hits	40
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.141142 (rank : 100)
Query Neighborhood Hits	129	Target Neighborhood Hits	177	Shared Neighborhood Hits	45
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NOXO1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.088435 (rank : 168)
Query Neighborhood Hits	129	Target Neighborhood Hits	100	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.102501 (rank : 148)
Query Neighborhood Hits	129	Target Neighborhood Hits	114	Shared Neighborhood Hits	29
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.080105 (rank : 178)
Query Neighborhood Hits	129	Target Neighborhood Hits	288	Shared Neighborhood Hits	40
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.095084 (rank : 160)
Query Neighborhood Hits	129	Target Neighborhood Hits	267	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OBSCN_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.061641 (rank : 220)
Query Neighborhood Hits	129	Target Neighborhood Hits	1931	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OSTF1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.096382 (rank : 156)
Query Neighborhood Hits	129	Target Neighborhood Hits	466	Shared Neighborhood Hits	44
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.094389 (rank : 162)
Query Neighborhood Hits	129	Target Neighborhood Hits	467	Shared Neighborhood Hits	44
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.063531 (rank : 212)
Query Neighborhood Hits	129	Target Neighborhood Hits	479	Shared Neighborhood Hits	39
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.062363 (rank : 217)
Query Neighborhood Hits	129	Target Neighborhood Hits	435	Shared Neighborhood Hits	38
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.052863 (rank : 251)
Query Neighborhood Hits	129	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.090870 (rank : 165)
Query Neighborhood Hits	129	Target Neighborhood Hits	320	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.089356 (rank : 166)
Query Neighborhood Hits	129	Target Neighborhood Hits	283	Shared Neighborhood Hits	55
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.095945 (rank : 157)
Query Neighborhood Hits	129	Target Neighborhood Hits	339	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.101735 (rank : 150)
Query Neighborhood Hits	129	Target Neighborhood Hits	382	Shared Neighborhood Hits	54
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.093114 (rank : 164)
Query Neighborhood Hits	129	Target Neighborhood Hits	385	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.094093 (rank : 163)
Query Neighborhood Hits	129	Target Neighborhood Hits	380	Shared Neighborhood Hits	50
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.076904 (rank : 183)
Query Neighborhood Hits	129	Target Neighborhood Hits	128	Shared Neighborhood Hits	32
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.081098 (rank : 174)
Query Neighborhood Hits	129	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA6_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.063030 (rank : 214)
Query Neighborhood Hits	129	Target Neighborhood Hits	556	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.064585 (rank : 209)
Query Neighborhood Hits	129	Target Neighborhood Hits	591	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.167219 (rank : 95)
Query Neighborhood Hits	129	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.166582 (rank : 96)
Query Neighborhood Hits	129	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.174548 (rank : 89)
Query Neighborhood Hits	129	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.173891 (rank : 90)
Query Neighborhood Hits	129	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.106599 (rank : 145)
Query Neighborhood Hits	129	Target Neighborhood Hits	293	Shared Neighborhood Hits	41
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.112566 (rank : 134)
Query Neighborhood Hits	129	Target Neighborhood Hits	314	Shared Neighborhood Hits	43
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.080472 (rank : 177)
Query Neighborhood Hits	129	Target Neighborhood Hits	280	Shared Neighborhood Hits	38
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.138135 (rank : 102)
Query Neighborhood Hits	129	Target Neighborhood Hits	389	Shared Neighborhood Hits	53
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.131672 (rank : 108)
Query Neighborhood Hits	129	Target Neighborhood Hits	377	Shared Neighborhood Hits	53
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RBNS5_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.088522 (rank : 167)
Query Neighborhood Hits	129	Target Neighborhood Hits	242	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.077874 (rank : 182)
Query Neighborhood Hits	129	Target Neighborhood Hits	266	Shared Neighborhood Hits	16
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.068996 (rank : 199)
Query Neighborhood Hits	129	Target Neighborhood Hits	205	Shared Neighborhood Hits	8
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.073944 (rank : 190)
Query Neighborhood Hits	129	Target Neighborhood Hits	204	Shared Neighborhood Hits	8
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.081288 (rank : 173)
Query Neighborhood Hits	129	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.080990 (rank : 176)
Query Neighborhood Hits	129	Target Neighborhood Hits	102	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.079231 (rank : 179)
Query Neighborhood Hits	129	Target Neighborhood Hits	307	Shared Neighborhood Hits	38
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.064992 (rank : 207)
Query Neighborhood Hits	129	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB2_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.067843 (rank : 202)
Query Neighborhood Hits	129	Target Neighborhood Hits	263	Shared Neighborhood Hits	33
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.068051 (rank : 201)
Query Neighborhood Hits	129	Target Neighborhood Hits	246	Shared Neighborhood Hits	30
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.059270 (rank : 229)
Query Neighborhood Hits	129	Target Neighborhood Hits	848	Shared Neighborhood Hits	31
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.059481 (rank : 227)
Query Neighborhood Hits	129	Target Neighborhood Hits	765	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.059467 (rank : 228)
Query Neighborhood Hits	129	Target Neighborhood Hits	1208	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.061387 (rank : 221)
Query Neighborhood Hits	129	Target Neighborhood Hits	820	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUSC1_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.058474 (rank : 231)
Query Neighborhood Hits	129	Target Neighborhood Hits	226	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.059716 (rank : 226)
Query Neighborhood Hits	129	Target Neighborhood Hits	206	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH3G1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.116336 (rank : 129)
Query Neighborhood Hits	129	Target Neighborhood Hits	307	Shared Neighborhood Hits	49
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.108222 (rank : 140)
Query Neighborhood Hits	129	Target Neighborhood Hits	291	Shared Neighborhood Hits	48
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.107984 (rank : 142)
Query Neighborhood Hits	129	Target Neighborhood Hits	324	Shared Neighborhood Hits	48
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.108168 (rank : 141)
Query Neighborhood Hits	129	Target Neighborhood Hits	319	Shared Neighborhood Hits	50
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.113620 (rank : 133)
Query Neighborhood Hits	129	Target Neighborhood Hits	222	Shared Neighborhood Hits	47
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.117416 (rank : 127)
Query Neighborhood Hits	129	Target Neighborhood Hits	236	Shared Neighborhood Hits	49
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SHAN2_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.095027 (rank : 161)
Query Neighborhood Hits	129	Target Neighborhood Hits	446	Shared Neighborhood Hits	43
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHLB1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.053588 (rank : 246)
Query Neighborhood Hits	129	Target Neighborhood Hits	96	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.053114 (rank : 250)
Query Neighborhood Hits	129	Target Neighborhood Hits	86	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.053314 (rank : 249)
Query Neighborhood Hits	129	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SNX18_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.069175 (rank : 198)
Query Neighborhood Hits	129	Target Neighborhood Hits	207	Shared Neighborhood Hits	35
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.070894 (rank : 196)
Query Neighborhood Hits	129	Target Neighborhood Hits	198	Shared Neighborhood Hits	34
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.062165 (rank : 218)
Query Neighborhood Hits	129	Target Neighborhood Hits	148	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SOS1_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.197161 (rank : 78)
Query Neighborhood Hits	129	Target Neighborhood Hits	274	Shared Neighborhood Hits	35
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.179851 (rank : 85)
Query Neighborhood Hits	129	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.173605 (rank : 91)
Query Neighborhood Hits	129	Target Neighborhood Hits	193	Shared Neighborhood Hits	38
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SPTA1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.056062 (rank : 237)
Query Neighborhood Hits	129	Target Neighborhood Hits	748	Shared Neighborhood Hits	51
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.057267 (rank : 234)
Query Neighborhood Hits	129	Target Neighborhood Hits	675	Shared Neighborhood Hits	47
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.060978 (rank : 222)
Query Neighborhood Hits	129	Target Neighborhood Hits	888	Shared Neighborhood Hits	57
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRC8_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.124382 (rank : 115)
Query Neighborhood Hits	129	Target Neighborhood Hits	269	Shared Neighborhood Hits	46
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.121902 (rank : 121)
Query Neighborhood Hits	129	Target Neighborhood Hits	292	Shared Neighborhood Hits	46
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.065552 (rank : 205)
Query Neighborhood Hits	129	Target Neighborhood Hits	390	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.064488 (rank : 210)
Query Neighborhood Hits	129	Target Neighborhood Hits	331	Shared Neighborhood Hits	39
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.065510 (rank : 206)
Query Neighborhood Hits	129	Target Neighborhood Hits	324	Shared Neighborhood Hits	40
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.110671 (rank : 138)
Query Neighborhood Hits	129	Target Neighborhood Hits	228	Shared Neighborhood Hits	42
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.111535 (rank : 135)
Query Neighborhood Hits	129	Target Neighborhood Hits	232	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.127864 (rank : 110)
Query Neighborhood Hits	129	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.123691 (rank : 116)
Query Neighborhood Hits	129	Target Neighborhood Hits	268	Shared Neighborhood Hits	49
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.122774 (rank : 119)
Query Neighborhood Hits	129	Target Neighborhood Hits	271	Shared Neighborhood Hits	45
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.123355 (rank : 118)
Query Neighborhood Hits	129	Target Neighborhood Hits	273	Shared Neighborhood Hits	44
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.115325 (rank : 131)
Query Neighborhood Hits	129	Target Neighborhood Hits	288	Shared Neighborhood Hits	44
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.116482 (rank : 128)
Query Neighborhood Hits	129	Target Neighborhood Hits	285	Shared Neighborhood Hits	44
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STS2_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.087462 (rank : 169)
Query Neighborhood Hits	129	Target Neighborhood Hits	108	Shared Neighborhood Hits	35
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCGAP_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.087218 (rank : 170)
Query Neighborhood Hits	129	Target Neighborhood Hits	872	Shared Neighborhood Hits	50
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

WDFY1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.056173 (rank : 236)
Query Neighborhood Hits	129	Target Neighborhood Hits	305	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY3_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.053411 (rank : 247)
Query Neighborhood Hits	129	Target Neighborhood Hits	348	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.052830 (rank : 252)
Query Neighborhood Hits	129	Target Neighborhood Hits	332	Shared Neighborhood Hits	13
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ZFY16_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.099910 (rank : 152)
Query Neighborhood Hits	129	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.102239 (rank : 149)
Query Neighborhood Hits	129	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.067834 (rank : 203)
Query Neighborhood Hits	129	Target Neighborhood Hits	206	Shared Neighborhood Hits	14
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.063126 (rank : 213)
Query Neighborhood Hits	129	Target Neighborhood Hits	143	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.095743 (rank : 158)
Query Neighborhood Hits	129	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.097851 (rank : 154)
Query Neighborhood Hits	129	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.107434 (rank : 143)
Query Neighborhood Hits	129	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.062920 (rank : 215)
Query Neighborhood Hits	129	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.061730 (rank : 219)
Query Neighborhood Hits	129	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.106960 (rank : 144)
Query Neighborhood Hits	129	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

ARHGG_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	129	Target Neighborhood Hits	129	Shared Neighborhood Hits	129
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.988458 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	129	Target Neighborhood Hits	152	Shared Neighborhood Hits	101
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG5_HUMAN
NC score	0.924523 (rank : 3)	θ value	4.36332e-79 (rank : 5)
Query Neighborhood Hits	129	Target Neighborhood Hits	172	Shared Neighborhood Hits	97
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_HUMAN
NC score	0.921373 (rank : 4)	θ value	1.49618e-87 (rank : 4)
Query Neighborhood Hits	129	Target Neighborhood Hits	166	Shared Neighborhood Hits	95
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
NC score	0.915839 (rank : 5)	θ value	3.93732e-88 (rank : 3)
Query Neighborhood Hits	129	Target Neighborhood Hits	228	Shared Neighborhood Hits	97
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGF_HUMAN
NC score	0.879263 (rank : 6)	θ value	2.03627e-60 (rank : 6)
Query Neighborhood Hits	129	Target Neighborhood Hits	214	Shared Neighborhood Hits	64
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG8_HUMAN
NC score	0.692352 (rank : 7)	θ value	7.09661e-13 (rank : 19)
Query Neighborhood Hits	129	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG1_HUMAN
NC score	0.689688 (rank : 8)	θ value	5.43371e-13 (rank : 18)
Query Neighborhood Hits	129	Target Neighborhood Hits	176	Shared Neighborhood Hits	62
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG3_HUMAN
NC score	0.687621 (rank : 9)	θ value	2.69671e-12 (rank : 23)
Query Neighborhood Hits	129	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.684073 (rank : 10)	θ value	2.98157e-11 (rank : 27)
Query Neighborhood Hits	129	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ECT2_MOUSE
NC score	0.677990 (rank : 11)	θ value	2.79066e-09 (rank : 43)
Query Neighborhood Hits	129	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG8_MOUSE
NC score	0.677409 (rank : 12)	θ value	8.38298e-14 (rank : 15)
Query Neighborhood Hits	129	Target Neighborhood Hits	79	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG2_MOUSE
NC score	0.671810 (rank : 13)	θ value	2.69671e-12 (rank : 22)
Query Neighborhood Hits	129	Target Neighborhood Hits	120	Shared Neighborhood Hits	65
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ECT2_HUMAN
NC score	0.668138 (rank : 14)	θ value	9.59137e-10 (rank : 40)
Query Neighborhood Hits	129	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.661398 (rank : 15)	θ value	9.26847e-13 (rank : 21)
Query Neighborhood Hits	129	Target Neighborhood Hits	177	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHGB_HUMAN
NC score	0.659218 (rank : 16)	θ value	1.86753e-13 (rank : 17)
Query Neighborhood Hits	129	Target Neighborhood Hits	375	Shared Neighborhood Hits	70
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG1_MOUSE
NC score	0.658485 (rank : 17)	θ value	4.59992e-12 (rank : 25)
Query Neighborhood Hits	129	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

FGD4_HUMAN
NC score	0.656941 (rank : 18)	θ value	1.92812e-18 (rank : 12)
Query Neighborhood Hits	129	Target Neighborhood Hits	219	Shared Neighborhood Hits	70
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.654487 (rank : 19)	θ value	3.88503e-19 (rank : 11)
Query Neighborhood Hits	129	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ARHGC_HUMAN
NC score	0.642912 (rank : 20)	θ value	2.60593e-15 (rank : 13)
Query Neighborhood Hits	129	Target Neighborhood Hits	351	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FGD3_MOUSE
NC score	0.641181 (rank : 21)	θ value	6.21693e-09 (rank : 44)
Query Neighborhood Hits	129	Target Neighborhood Hits	257	Shared Neighborhood Hits	69
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHGC_MOUSE
NC score	0.641083 (rank : 22)	θ value	9.90251e-15 (rank : 14)
Query Neighborhood Hits	129	Target Neighborhood Hits	344	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG2_HUMAN
NC score	0.638909 (rank : 23)	θ value	1.133e-10 (rank : 33)
Query Neighborhood Hits	129	Target Neighborhood Hits	142	Shared Neighborhood Hits	62
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

PKHG1_HUMAN
NC score	0.636236 (rank : 24)	θ value	2.28291e-11 (rank : 26)
Query Neighborhood Hits	129	Target Neighborhood Hits	174	Shared Neighborhood Hits	67
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG4_MOUSE
NC score	0.634121 (rank : 25)	θ value	5.62301e-10 (rank : 38)
Query Neighborhood Hits	129	Target Neighborhood Hits	185	Shared Neighborhood Hits	81
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD2_MOUSE
NC score	0.633726 (rank : 26)	θ value	3.89403e-11 (rank : 29)
Query Neighborhood Hits	129	Target Neighborhood Hits	163	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.632093 (rank : 27)	θ value	5.62301e-10 (rank : 39)
Query Neighborhood Hits	129	Target Neighborhood Hits	151	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

LBC_HUMAN
NC score	0.629764 (rank : 28)	θ value	8.67504e-11 (rank : 32)
Query Neighborhood Hits	129	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG4_HUMAN
NC score	0.627414 (rank : 29)	θ value	2.69671e-12 (rank : 24)
Query Neighborhood Hits	129	Target Neighborhood Hits	242	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD1_HUMAN
NC score	0.623624 (rank : 30)	θ value	1.09485e-13 (rank : 16)
Query Neighborhood Hits	129	Target Neighborhood Hits	367	Shared Neighborhood Hits	68
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.623025 (rank : 31)	θ value	9.26847e-13 (rank : 20)
Query Neighborhood Hits	129	Target Neighborhood Hits	387	Shared Neighborhood Hits	68
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

TIAM1_MOUSE
NC score	0.622988 (rank : 32)	θ value	6.64225e-11 (rank : 31)
Query Neighborhood Hits	129	Target Neighborhood Hits	205	Shared Neighborhood Hits	70
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD3_HUMAN
NC score	0.621317 (rank : 33)	θ value	4.0297e-08 (rank : 48)
Query Neighborhood Hits	129	Target Neighborhood Hits	249	Shared Neighborhood Hits	67
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ARHG9_MOUSE
NC score	0.619484 (rank : 34)	θ value	2.52405e-10 (rank : 35)
Query Neighborhood Hits	129	Target Neighborhood Hits	234	Shared Neighborhood Hits	88
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.619212 (rank : 35)	θ value	3.29651e-10 (rank : 36)
Query Neighborhood Hits	129	Target Neighborhood Hits	235	Shared Neighborhood Hits	90
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

TIAM1_HUMAN
NC score	0.609959 (rank : 36)	θ value	1.63604e-09 (rank : 42)
Query Neighborhood Hits	129	Target Neighborhood Hits	225	Shared Neighborhood Hits	70
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

RGNEF_MOUSE
NC score	0.553369 (rank : 37)	θ value	1.9326e-10 (rank : 34)
Query Neighborhood Hits	129	Target Neighborhood Hits	641	Shared Neighborhood Hits	69
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

FGD6_MOUSE
NC score	0.551310 (rank : 38)	θ value	1.38499e-08 (rank : 46)
Query Neighborhood Hits	129	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.548788 (rank : 39)	θ value	6.87365e-08 (rank : 49)
Query Neighborhood Hits	129	Target Neighborhood Hits	237	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ITSN2_HUMAN
NC score	0.523382 (rank : 40)	θ value	8.93572e-24 (rank : 7)
Query Neighborhood Hits	129	Target Neighborhood Hits	1173	Shared Neighborhood Hits	108
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MCF2_HUMAN
NC score	0.519399 (rank : 41)	θ value	0.000158464 (rank : 60)
Query Neighborhood Hits	129	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

VAV2_HUMAN
NC score	0.498162 (rank : 42)	θ value	3.89403e-11 (rank : 30)
Query Neighborhood Hits	129	Target Neighborhood Hits	453	Shared Neighborhood Hits	90
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ITSN2_MOUSE
NC score	0.497251 (rank : 43)	θ value	2.20094e-22 (rank : 10)
Query Neighborhood Hits	129	Target Neighborhood Hits	1371	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DNMBP_MOUSE
NC score	0.497220 (rank : 44)	θ value	0.000602161 (rank : 62)
Query Neighborhood Hits	129	Target Neighborhood Hits	435	Shared Neighborhood Hits	96
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_MOUSE
NC score	0.494874 (rank : 45)	θ value	2.98157e-11 (rank : 28)
Query Neighborhood Hits	129	Target Neighborhood Hits	456	Shared Neighborhood Hits	91
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

MCF2L_MOUSE
NC score	0.491509 (rank : 46)	θ value	0.000602161 (rank : 63)
Query Neighborhood Hits	129	Target Neighborhood Hits	255	Shared Neighborhood Hits	68
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

VAV_MOUSE
NC score	0.482539 (rank : 47)	θ value	4.45536e-07 (rank : 52)
Query Neighborhood Hits	129	Target Neighborhood Hits	430	Shared Neighborhood Hits	97
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ITSN1_MOUSE
NC score	0.481919 (rank : 48)	θ value	1.99067e-23 (rank : 9)
Query Neighborhood Hits	129	Target Neighborhood Hits	1669	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.481907 (rank : 49)	θ value	1.16704e-23 (rank : 8)
Query Neighborhood Hits	129	Target Neighborhood Hits	1757	Shared Neighborhood Hits	110
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

DNMBP_HUMAN
NC score	0.478251 (rank : 50)	θ value	2.44474e-05 (rank : 58)
Query Neighborhood Hits	129	Target Neighborhood Hits	413	Shared Neighborhood Hits	98
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GNRP_MOUSE
NC score	0.475221 (rank : 51)	θ value	9.92553e-07 (rank : 53)
Query Neighborhood Hits	129	Target Neighborhood Hits	191	Shared Neighborhood Hits	58
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGA_HUMAN
NC score	0.474836 (rank : 52)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	129	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

VAV_HUMAN
NC score	0.473941 (rank : 53)	θ value	1.06045e-08 (rank : 45)
Query Neighborhood Hits	129	Target Neighborhood Hits	452	Shared Neighborhood Hits	97
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHGA_MOUSE
NC score	0.452470 (rank : 54)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	129	Target Neighborhood Hits	125	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FARP2_MOUSE
NC score	0.445598 (rank : 55)	θ value	3.29651e-10 (rank : 37)
Query Neighborhood Hits	129	Target Neighborhood Hits	209	Shared Neighborhood Hits	68
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GNRP_HUMAN
NC score	0.441077 (rank : 56)	θ value	1.29631e-06 (rank : 54)
Query Neighborhood Hits	129	Target Neighborhood Hits	239	Shared Neighborhood Hits	56
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

HAPIP_HUMAN
NC score	0.438907 (rank : 57)	θ value	8.40245e-06 (rank : 57)
Query Neighborhood Hits	129	Target Neighborhood Hits	350	Shared Neighborhood Hits	72
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

VAV3_MOUSE
NC score	0.433372 (rank : 58)	θ value	0.00035302 (rank : 61)
Query Neighborhood Hits	129	Target Neighborhood Hits	404	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.426727 (rank : 59)	θ value	0.00228821 (rank : 66)
Query Neighborhood Hits	129	Target Neighborhood Hits	398	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FGD5_HUMAN
NC score	0.423543 (rank : 60)	θ value	1.69304e-06 (rank : 55)
Query Neighborhood Hits	129	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHG7_HUMAN
NC score	0.414778 (rank : 61)	θ value	0.47712 (rank : 83)
Query Neighborhood Hits	129	Target Neighborhood Hits	347	Shared Neighborhood Hits	92
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

FARP2_HUMAN
NC score	0.412503 (rank : 62)	θ value	1.25267e-09 (rank : 41)
Query Neighborhood Hits	129	Target Neighborhood Hits	240	Shared Neighborhood Hits	62
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG7_MOUSE
NC score	0.411822 (rank : 63)	θ value	0.21417 (rank : 78)
Query Neighborhood Hits	129	Target Neighborhood Hits	396	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

FGD5_MOUSE
NC score	0.411149 (rank : 64)	θ value	3.41135e-07 (rank : 51)
Query Neighborhood Hits	129	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP1_HUMAN
NC score	0.390993 (rank : 65)	θ value	1.53129e-07 (rank : 50)
Query Neighborhood Hits	129	Target Neighborhood Hits	241	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG6_HUMAN
NC score	0.383356 (rank : 66)	θ value	0.0736092 (rank : 74)
Query Neighborhood Hits	129	Target Neighborhood Hits	376	Shared Neighborhood Hits	86
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
NC score	0.368320 (rank : 67)	θ value	0.365318 (rank : 80)
Query Neighborhood Hits	129	Target Neighborhood Hits	394	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PKHG4_HUMAN
NC score	0.339099 (rank : 68)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	129	Target Neighborhood Hits	200	Shared Neighborhood Hits	54
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

BCR_HUMAN
NC score	0.335339 (rank : 69)	θ value	0.0113563 (rank : 69)
Query Neighborhood Hits	129	Target Neighborhood Hits	204	Shared Neighborhood Hits	61
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.334225 (rank : 70)	θ value	9.29e-05 (rank : 59)
Query Neighborhood Hits	129	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

SH3K1_HUMAN
NC score	0.223543 (rank : 71)	θ value	0.21417 (rank : 79)
Query Neighborhood Hits	129	Target Neighborhood Hits	341	Shared Neighborhood Hits	56
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.214603 (rank : 72)	θ value	0.0736092 (rank : 75)
Query Neighborhood Hits	129	Target Neighborhood Hits	332	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_MOUSE
NC score	0.212476 (rank : 73)	θ value	0.47712 (rank : 86)
Query Neighborhood Hits	129	Target Neighborhood Hits	409	Shared Neighborhood Hits	54
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CD2AP_HUMAN
NC score	0.209829 (rank : 74)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	129	Target Neighborhood Hits	315	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.208632 (rank : 75)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	129	Target Neighborhood Hits	336	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SRBS1_HUMAN
NC score	0.206125 (rank : 76)	θ value	0.47712 (rank : 85)
Query Neighborhood Hits	129	Target Neighborhood Hits	396	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF2_HUMAN
NC score	0.205784 (rank : 77)	θ value	0.62314 (rank : 87)
Query Neighborhood Hits	129	Target Neighborhood Hits	229	Shared Neighborhood Hits	52
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SOS1_HUMAN
NC score	0.197161 (rank : 78)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	129	Target Neighborhood Hits	274	Shared Neighborhood Hits	35
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

BI2L1_HUMAN
NC score	0.196429 (rank : 79)	θ value	0.0330416 (rank : 72)
Query Neighborhood Hits	129	Target Neighborhood Hits	156	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

NCF1_HUMAN
NC score	0.192220 (rank : 80)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	129	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

VINEX_HUMAN
NC score	0.191802 (rank : 81)	θ value	2.36792 (rank : 101)
Query Neighborhood Hits	129	Target Neighborhood Hits	270	Shared Neighborhood Hits	54
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

DUET_HUMAN
NC score	0.191717 (rank : 82)	θ value	4.0297e-08 (rank : 47)
Query Neighborhood Hits	129	Target Neighborhood Hits	1220	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NCF1_MOUSE
NC score	0.189264 (rank : 83)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	129	Target Neighborhood Hits	198	Shared Neighborhood Hits	49
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

VINEX_MOUSE
NC score	0.186662 (rank : 84)	θ value	2.36792 (rank : 102)
Query Neighborhood Hits	129	Target Neighborhood Hits	286	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SOS1_MOUSE
NC score	0.179851 (rank : 85)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	129	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

BI2L1_MOUSE
NC score	0.176200 (rank : 86)	θ value	0.0252991 (rank : 71)
Query Neighborhood Hits	129	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

NCK1_HUMAN
NC score	0.175255 (rank : 87)	θ value	0.47712 (rank : 84)
Query Neighborhood Hits	129	Target Neighborhood Hits	312	Shared Neighborhood Hits	57
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

TRIO_HUMAN
NC score	0.175179 (rank : 88)	θ value	2.88788e-06 (rank : 56)
Query Neighborhood Hits	129	Target Neighborhood Hits	1580	Shared Neighborhood Hits	88
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PKHF2_HUMAN
NC score	0.174548 (rank : 89)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	129	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.173891 (rank : 90)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	129	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

SOS2_HUMAN
NC score	0.173605 (rank : 91)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	129	Target Neighborhood Hits	193	Shared Neighborhood Hits	38
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

LASP1_HUMAN
NC score	0.173424 (rank : 92)	θ value	0.00175202 (rank : 64)
Query Neighborhood Hits	129	Target Neighborhood Hits	293	Shared Neighborhood Hits	52
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCK2_HUMAN
NC score	0.173215 (rank : 93)	θ value	0.365318 (rank : 81)
Query Neighborhood Hits	129	Target Neighborhood Hits	310	Shared Neighborhood Hits	50
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

LASP1_MOUSE
NC score	0.171628 (rank : 94)	θ value	0.00175202 (rank : 65)
Query Neighborhood Hits	129	Target Neighborhood Hits	297	Shared Neighborhood Hits	52
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PKHF1_HUMAN
NC score	0.167219 (rank : 95)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	129	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.166582 (rank : 96)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	129	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

BAIP2_MOUSE
NC score	0.152408 (rank : 97)	θ value	0.125558 (rank : 77)
Query Neighborhood Hits	129	Target Neighborhood Hits	185	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAIP2_HUMAN
NC score	0.151811 (rank : 98)	θ value	0.125558 (rank : 76)
Query Neighborhood Hits	129	Target Neighborhood Hits	192	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

NEBL_HUMAN
NC score	0.144861 (rank : 99)	θ value	0.00509761 (rank : 68)
Query Neighborhood Hits	129	Target Neighborhood Hits	457	Shared Neighborhood Hits	51
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NCF4_MOUSE
NC score	0.141142 (rank : 100)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	129	Target Neighborhood Hits	177	Shared Neighborhood Hits	45
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_HUMAN
NC score	0.138703 (rank : 101)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	129	Target Neighborhood Hits	161	Shared Neighborhood Hits	40
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PPIP1_HUMAN
NC score	0.138135 (rank : 102)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	129	Target Neighborhood Hits	389	Shared Neighborhood Hits	53
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI2_MOUSE
NC score	0.136494 (rank : 103)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	129	Target Neighborhood Hits	266	Shared Neighborhood Hits	49
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.135813 (rank : 104)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	129	Target Neighborhood Hits	350	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI1_MOUSE
NC score	0.134974 (rank : 105)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	129	Target Neighborhood Hits	246	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

GRAP_HUMAN
NC score	0.134047 (rank : 106)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	129	Target Neighborhood Hits	307	Shared Neighborhood Hits	47
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.133217 (rank : 107)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	129	Target Neighborhood Hits	309	Shared Neighborhood Hits	48
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PPIP1_MOUSE
NC score	0.131672 (rank : 108)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	129	Target Neighborhood Hits	377	Shared Neighborhood Hits	53
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

AMPH_HUMAN
NC score	0.131125 (rank : 109)	θ value	0.00390308 (rank : 67)
Query Neighborhood Hits	129	Target Neighborhood Hits	455	Shared Neighborhood Hits	39
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

STAC_HUMAN
NC score	0.127864 (rank : 110)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	129	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

AHI1_MOUSE
NC score	0.126969 (rank : 111)	θ value	0.47712 (rank : 82)
Query Neighborhood Hits	129	Target Neighborhood Hits	496	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AHI1_HUMAN
NC score	0.126610 (rank : 112)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	129	Target Neighborhood Hits	537	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

BIN1_MOUSE
NC score	0.126532 (rank : 113)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	129	Target Neighborhood Hits	283	Shared Neighborhood Hits	42
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

ABI1_HUMAN
NC score	0.124920 (rank : 114)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	129	Target Neighborhood Hits	257	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SRC8_HUMAN
NC score	0.124382 (rank : 115)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	129	Target Neighborhood Hits	269	Shared Neighborhood Hits	46
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAC_MOUSE
NC score	0.123691 (rank : 116)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	129	Target Neighborhood Hits	268	Shared Neighborhood Hits	49
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

AMPH_MOUSE
NC score	0.123492 (rank : 117)	θ value	0.0148317 (rank : 70)
Query Neighborhood Hits	129	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

STAM1_MOUSE
NC score	0.123355 (rank : 118)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	129	Target Neighborhood Hits	273	Shared Neighborhood Hits	44
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.122774 (rank : 119)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	129	Target Neighborhood Hits	271	Shared Neighborhood Hits	45
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

BIN1_HUMAN
NC score	0.122003 (rank : 120)	θ value	0.813845 (rank : 89)
Query Neighborhood Hits	129	Target Neighborhood Hits	335	Shared Neighborhood Hits	40
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SRC8_MOUSE
NC score	0.121902 (rank : 121)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	129	Target Neighborhood Hits	292	Shared Neighborhood Hits	46
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

NEBU_HUMAN
NC score	0.121824 (rank : 122)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	129	Target Neighborhood Hits	420	Shared Neighborhood Hits	55
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

HCLS1_MOUSE
NC score	0.121353 (rank : 123)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	129	Target Neighborhood Hits	329	Shared Neighborhood Hits	44
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

GRB2_HUMAN
NC score	0.120631 (rank : 124)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	129	Target Neighborhood Hits	310	Shared Neighborhood Hits	47
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.120487 (rank : 125)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	129	Target Neighborhood Hits	312	Shared Neighborhood Hits	47
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
NC score	0.119086 (rank : 126)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	129	Target Neighborhood Hits	358	Shared Neighborhood Hits	46
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SH3G3_MOUSE
NC score	0.117416 (rank : 127)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	129	Target Neighborhood Hits	236	Shared Neighborhood Hits	49
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

STAM2_MOUSE
NC score	0.116482 (rank : 128)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	129	Target Neighborhood Hits	285	Shared Neighborhood Hits	44
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SH3G1_HUMAN
NC score	0.116336 (rank : 129)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	129	Target Neighborhood Hits	307	Shared Neighborhood Hits	49
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ABI3_HUMAN
NC score	0.115555 (rank : 130)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	129	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAM2_HUMAN
NC score	0.115325 (rank : 131)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	129	Target Neighborhood Hits	288	Shared Neighborhood Hits	44
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ABI3_MOUSE
NC score	0.115218 (rank : 132)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	129	Target Neighborhood Hits	227	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G3_HUMAN
NC score	0.113620 (rank : 133)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	129	Target Neighborhood Hits	222	Shared Neighborhood Hits	47
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

PLCG1_MOUSE
NC score	0.112566 (rank : 134)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	129	Target Neighborhood Hits	314	Shared Neighborhood Hits	43
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

STAC3_MOUSE
NC score	0.111535 (rank : 135)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	129	Target Neighborhood Hits	232	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRAP2_MOUSE
NC score	0.111461 (rank : 136)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	129	Target Neighborhood Hits	297	Shared Neighborhood Hits	46
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.111021 (rank : 137)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	129	Target Neighborhood Hits	304	Shared Neighborhood Hits	45
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

STAC3_HUMAN
NC score	0.110671 (rank : 138)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	129	Target Neighborhood Hits	228	Shared Neighborhood Hits	42
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TCGAP_MOUSE
NC score	0.108792 (rank : 139)	θ value	0.0431538 (rank : 73)
Query Neighborhood Hits	129	Target Neighborhood Hits	409	Shared Neighborhood Hits	50
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SH3G1_MOUSE
NC score	0.108222 (rank : 140)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	129	Target Neighborhood Hits	291	Shared Neighborhood Hits	48
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_MOUSE
NC score	0.108168 (rank : 141)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	129	Target Neighborhood Hits	319	Shared Neighborhood Hits	50
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G2_HUMAN
NC score	0.107984 (rank : 142)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	129	Target Neighborhood Hits	324	Shared Neighborhood Hits	48
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ZFY28_HUMAN
NC score	0.107434 (rank : 143)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	129	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.106960 (rank : 144)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	129	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PLCG1_HUMAN
NC score	0.106599 (rank : 145)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	129	Target Neighborhood Hits	293	Shared Neighborhood Hits	41
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CRKL_HUMAN
NC score	0.105887 (rank : 146)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	129	Target Neighborhood Hits	313	Shared Neighborhood Hits	42
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.102995 (rank : 147)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	129	Target Neighborhood Hits	307	Shared Neighborhood Hits	41
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

NOXO1_MOUSE
NC score	0.102501 (rank : 148)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	129	Target Neighborhood Hits	114	Shared Neighborhood Hits	29
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ZFY16_MOUSE
NC score	0.102239 (rank : 149)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	129	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

PACN2_MOUSE
NC score	0.101735 (rank : 150)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	129	Target Neighborhood Hits	382	Shared Neighborhood Hits	54
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

DBNL_HUMAN
NC score	0.101614 (rank : 151)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	129	Target Neighborhood Hits	244	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ZFY16_HUMAN
NC score	0.099910 (rank : 152)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	129	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

CRK_MOUSE
NC score	0.098542 (rank : 153)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	129	Target Neighborhood Hits	314	Shared Neighborhood Hits	44
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ZFY21_MOUSE
NC score	0.097851 (rank : 154)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	129	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

DBNL_MOUSE
NC score	0.096667 (rank : 155)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	129	Target Neighborhood Hits	306	Shared Neighborhood Hits	39
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

OSTF1_HUMAN
NC score	0.096382 (rank : 156)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	129	Target Neighborhood Hits	466	Shared Neighborhood Hits	44
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PACN2_HUMAN
NC score	0.095945 (rank : 157)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	129	Target Neighborhood Hits	339	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ZFY21_HUMAN
NC score	0.095743 (rank : 158)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	129	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

CRK_HUMAN
NC score	0.095182 (rank : 159)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	129	Target Neighborhood Hits	308	Shared Neighborhood Hits	43
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NPHP1_MOUSE
NC score	0.095084 (rank : 160)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	129	Target Neighborhood Hits	267	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SHAN2_MOUSE
NC score	0.095027 (rank : 161)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	129	Target Neighborhood Hits	446	Shared Neighborhood Hits	43
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

OSTF1_MOUSE
NC score	0.094389 (rank : 162)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	129	Target Neighborhood Hits	467	Shared Neighborhood Hits	44
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN3_MOUSE
NC score	0.094093 (rank : 163)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	129	Target Neighborhood Hits	380	Shared Neighborhood Hits	50
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.093114 (rank : 164)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	129	Target Neighborhood Hits	385	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN1_HUMAN
NC score	0.090870 (rank : 165)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	129	Target Neighborhood Hits	320	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.089356 (rank : 166)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	129	Target Neighborhood Hits	283	Shared Neighborhood Hits	55
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RBNS5_HUMAN
NC score	0.088522 (rank : 167)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	129	Target Neighborhood Hits	242	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

NOXO1_HUMAN
NC score	0.088435 (rank : 168)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	129	Target Neighborhood Hits	100	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

STS2_HUMAN
NC score	0.087462 (rank : 169)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	129	Target Neighborhood Hits	108	Shared Neighborhood Hits	35
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCGAP_HUMAN
NC score	0.087218 (rank : 170)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	129	Target Neighborhood Hits	872	Shared Neighborhood Hits	50
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

HGS_MOUSE
NC score	0.085016 (rank : 171)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	129	Target Neighborhood Hits	589	Shared Neighborhood Hits	23
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.084971 (rank : 172)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	129	Target Neighborhood Hits	517	Shared Neighborhood Hits	23
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

REPS2_HUMAN
NC score	0.081288 (rank : 173)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	129	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

PEX13_MOUSE
NC score	0.081098 (rank : 174)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	129	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ANM2_HUMAN
NC score	0.081061 (rank : 175)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	129	Target Neighborhood Hits	175	Shared Neighborhood Hits	36
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

REPS2_MOUSE
NC score	0.080990 (rank : 176)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	129	Target Neighborhood Hits	102	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

PLCG2_HUMAN
NC score	0.080472 (rank : 177)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	129	Target Neighborhood Hits	280	Shared Neighborhood Hits	38
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NPHP1_HUMAN
NC score	0.080105 (rank : 178)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	129	Target Neighborhood Hits	288	Shared Neighborhood Hits	40
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RHG04_HUMAN
NC score	0.079231 (rank : 179)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	129	Target Neighborhood Hits	307	Shared Neighborhood Hits	38
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

BCAR1_MOUSE
NC score	0.078194 (rank : 180)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	129	Target Neighborhood Hits	438	Shared Neighborhood Hits	43
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EFS_MOUSE
NC score	0.078140 (rank : 181)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	129	Target Neighborhood Hits	389	Shared Neighborhood Hits	43
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

RBNS5_MOUSE
NC score	0.077874 (rank : 182)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	129	Target Neighborhood Hits	266	Shared Neighborhood Hits	16
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

PEX13_HUMAN
NC score	0.076904 (rank : 183)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	129	Target Neighborhood Hits	128	Shared Neighborhood Hits	32
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

STS1_HUMAN
NC score	0.076523 (rank : 184)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SHAN1_HUMAN
NC score	0.076246 (rank : 185)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	129	Target Neighborhood Hits	1041	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ANM2_MOUSE
NC score	0.076155 (rank : 186)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	129	Target Neighborhood Hits	175	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

STS1_MOUSE
NC score	0.075706 (rank : 187)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

DDEF2_HUMAN
NC score	0.075444 (rank : 188)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	129	Target Neighborhood Hits	599	Shared Neighborhood Hits	58
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CT032_HUMAN
NC score	0.074008 (rank : 189)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	129	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

REPS1_MOUSE
NC score	0.073944 (rank : 190)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	129	Target Neighborhood Hits	204	Shared Neighborhood Hits	8
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

JIP2_HUMAN
NC score	0.073795 (rank : 191)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	129	Target Neighborhood Hits	288	Shared Neighborhood Hits	30
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

BCAR1_HUMAN
NC score	0.073218 (rank : 192)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	129	Target Neighborhood Hits	554	Shared Neighborhood Hits	42
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

JIP2_MOUSE
NC score	0.073027 (rank : 193)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	129	Target Neighborhood Hits	144	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

DDEF2_MOUSE
NC score	0.072829 (rank : 194)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	129	Target Neighborhood Hits	625	Shared Neighborhood Hits	54
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CASL_HUMAN
NC score	0.072435 (rank : 195)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	129	Target Neighborhood Hits	259	Shared Neighborhood Hits	39
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

SNX18_MOUSE
NC score	0.070894 (rank : 196)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	129	Target Neighborhood Hits	198	Shared Neighborhood Hits	34
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

EFS_HUMAN
NC score	0.070036 (rank : 197)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	129	Target Neighborhood Hits	348	Shared Neighborhood Hits	40
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SNX18_HUMAN
NC score	0.069175 (rank : 198)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	129	Target Neighborhood Hits	207	Shared Neighborhood Hits	35
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

REPS1_HUMAN
NC score	0.068996 (rank : 199)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	129	Target Neighborhood Hits	205	Shared Neighborhood Hits	8
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

CASL_MOUSE
NC score	0.068060 (rank : 200)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	129	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

RIMB2_MOUSE
NC score	0.068051 (rank : 201)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	129	Target Neighborhood Hits	246	Shared Neighborhood Hits	30
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_HUMAN
NC score	0.067843 (rank : 202)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	129	Target Neighborhood Hits	263	Shared Neighborhood Hits	33
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ZFY19_HUMAN
NC score	0.067834 (rank : 203)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	129	Target Neighborhood Hits	206	Shared Neighborhood Hits	14
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

DDEF1_MOUSE
NC score	0.066859 (rank : 204)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	129	Target Neighborhood Hits	592	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

SRGP1_HUMAN
NC score	0.065552 (rank : 205)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	129	Target Neighborhood Hits	390	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_MOUSE
NC score	0.065510 (rank : 206)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	129	Target Neighborhood Hits	324	Shared Neighborhood Hits	40
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RHG26_HUMAN
NC score	0.064992 (rank : 207)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	129	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

DOCK1_HUMAN
NC score	0.064915 (rank : 208)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	129	Target Neighborhood Hits	191	Shared Neighborhood Hits	42
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

PKHA6_MOUSE
NC score	0.064585 (rank : 209)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	129	Target Neighborhood Hits	591	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SRGP2_HUMAN
NC score	0.064488 (rank : 210)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	129	Target Neighborhood Hits	331	Shared Neighborhood Hits	39
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

FNBP2_HUMAN
NC score	0.063668 (rank : 211)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	129	Target Neighborhood Hits	432	Shared Neighborhood Hits	42
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

P85A_HUMAN
NC score	0.063531 (rank : 212)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	129	Target Neighborhood Hits	479	Shared Neighborhood Hits	39
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ZFY19_MOUSE
NC score	0.063126 (rank : 213)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	129	Target Neighborhood Hits	143	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

PKHA6_HUMAN
NC score	0.063030 (rank : 214)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	129	Target Neighborhood Hits	556	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ZFYV1_HUMAN
NC score	0.062920 (rank : 215)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	129	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

IASPP_HUMAN
NC score	0.062728 (rank : 216)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	129	Target Neighborhood Hits	688	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

P85A_MOUSE
NC score	0.062363 (rank : 217)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	129	Target Neighborhood Hits	435	Shared Neighborhood Hits	38
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNX9_HUMAN
NC score	0.062165 (rank : 218)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	129	Target Neighborhood Hits	148	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

ZFYV1_MOUSE
NC score	0.061730 (rank : 219)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	129	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

OBSCN_HUMAN
NC score	0.061641 (rank : 220)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	129	Target Neighborhood Hits	1931	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

RUFY2_MOUSE
NC score	0.061387 (rank : 221)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	129	Target Neighborhood Hits	820	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SPTA2_HUMAN
NC score	0.060978 (rank : 222)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	129	Target Neighborhood Hits	888	Shared Neighborhood Hits	57
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

IASPP_MOUSE
NC score	0.060934 (rank : 223)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	129	Target Neighborhood Hits	1024	Shared Neighborhood Hits	48
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MYO1E_HUMAN
NC score	0.060565 (rank : 224)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	129	Target Neighborhood Hits	293	Shared Neighborhood Hits	51
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

FYV1_HUMAN
NC score	0.059950 (rank : 225)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	129	Target Neighborhood Hits	217	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

RUSC1_MOUSE
NC score	0.059716 (rank : 226)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	129	Target Neighborhood Hits	206	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUFY1_MOUSE
NC score	0.059481 (rank : 227)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	129	Target Neighborhood Hits	765	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
NC score	0.059467 (rank : 228)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	129	Target Neighborhood Hits	1208	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY1_HUMAN
NC score	0.059270 (rank : 229)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	129	Target Neighborhood Hits	848	Shared Neighborhood Hits	31
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

MYO1F_MOUSE
NC score	0.058971 (rank : 230)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	129	Target Neighborhood Hits	262	Shared Neighborhood Hits	44
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

RUSC1_HUMAN
NC score	0.058474 (rank : 231)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	129	Target Neighborhood Hits	226	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

FYV1_MOUSE
NC score	0.058454 (rank : 232)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	129	Target Neighborhood Hits	191	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

MYO1F_HUMAN
NC score	0.058333 (rank : 233)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	129	Target Neighborhood Hits	275	Shared Neighborhood Hits	44
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SPTA1_MOUSE
NC score	0.057267 (rank : 234)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	129	Target Neighborhood Hits	675	Shared Neighborhood Hits	47
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ASPP1_MOUSE
NC score	0.057061 (rank : 235)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	129	Target Neighborhood Hits	1244	Shared Neighborhood Hits	54
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

WDFY1_HUMAN
NC score	0.056173 (rank : 236)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	129	Target Neighborhood Hits	305	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

SPTA1_HUMAN
NC score	0.056062 (rank : 237)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	129	Target Neighborhood Hits	748	Shared Neighborhood Hits	51
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

EHD1_HUMAN
NC score	0.055158 (rank : 238)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	129	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
NC score	0.055067 (rank : 239)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	129	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EP15_MOUSE
NC score	0.054525 (rank : 240)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	129	Target Neighborhood Hits	820	Shared Neighborhood Hits	21
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EHD2_HUMAN
NC score	0.054465 (rank : 241)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	129	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD3_HUMAN
NC score	0.054424 (rank : 242)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	129	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD3_MOUSE
NC score	0.053985 (rank : 243)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	129	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

ASPP1_HUMAN
NC score	0.053885 (rank : 244)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	129	Target Neighborhood Hits	956	Shared Neighborhood Hits	50
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

EHD4_MOUSE
NC score	0.053817 (rank : 245)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	129	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

SHLB1_HUMAN
NC score	0.053588 (rank : 246)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	129	Target Neighborhood Hits	96	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

WDFY3_HUMAN
NC score	0.053411 (rank : 247)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	129	Target Neighborhood Hits	348	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

EP15R_MOUSE
NC score	0.053328 (rank : 248)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	129	Target Neighborhood Hits	1135	Shared Neighborhood Hits	21
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

SHLB2_MOUSE
NC score	0.053314 (rank : 249)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	129	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.053114 (rank : 250)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	129	Target Neighborhood Hits	86	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

P85B_HUMAN
NC score	0.052863 (rank : 251)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	129	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

WDFY3_MOUSE
NC score	0.052830 (rank : 252)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	129	Target Neighborhood Hits	332	Shared Neighborhood Hits	13
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

EP15_HUMAN
NC score	0.051749 (rank : 253)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	129	Target Neighborhood Hits	1021	Shared Neighborhood Hits	22
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EEA1_MOUSE
NC score	0.051714 (rank : 254)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	129	Target Neighborhood Hits	1637	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EEA1_HUMAN
NC score	0.051381 (rank : 255)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	129	Target Neighborhood Hits	1796	Shared Neighborhood Hits	42
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EHD4_HUMAN
NC score	0.050696 (rank : 256)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	129	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H223, Q9HAR1, Q9NZN2	Gene names	EHD4, HCA10, HCA11
Domain Architecture
Description	EH-domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11).

ES8L3_MOUSE
NC score	0.050379 (rank : 257)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	129	Target Neighborhood Hits	168	Shared Neighborhood Hits	34
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

GRP3_HUMAN
NC score	0.050323 (rank : 258)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	129	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

EP15R_HUMAN
NC score	0.050103 (rank : 259)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	129	Target Neighborhood Hits	1083	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

SYNG_HUMAN
NC score	0.044990 (rank : 260)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	129	Target Neighborhood Hits	160	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

RASA1_HUMAN
NC score	0.035825 (rank : 261)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	129	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

CENPJ_HUMAN
NC score	0.029380 (rank : 262)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	129	Target Neighborhood Hits	721	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

RGS3_HUMAN
NC score	0.026372 (rank : 263)	θ value	2.36792 (rank : 100)
Query Neighborhood Hits	129	Target Neighborhood Hits	1375	Shared Neighborhood Hits	27
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TRIPB_HUMAN
NC score	0.023818 (rank : 264)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	129	Target Neighborhood Hits	1587	Shared Neighborhood Hits	39
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

HOOK1_HUMAN
NC score	0.023145 (rank : 265)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	129	Target Neighborhood Hits	942	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

GOGA2_MOUSE
NC score	0.023081 (rank : 266)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	129	Target Neighborhood Hits	944	Shared Neighborhood Hits	20
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

HOOK1_MOUSE
NC score	0.021135 (rank : 267)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	129	Target Neighborhood Hits	910	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

2A5D_HUMAN
NC score	0.018766 (rank : 268)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	129	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	Q14738, O00494, O00696, Q15171	Gene names	PPP2R5D
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (PP2A, B subunit, B56 delta isoform) (PP2A, B subunit, PR61 delta isoform) (PP2A, B subunit, R5 delta isoform).

CAN7_MOUSE
NC score	0.017588 (rank : 269)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	129	Target Neighborhood Hits	66	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1S8, Q9Z0P9	Gene names	Capn7, Palbh
Domain Architecture
Description	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH).

DYNA_HUMAN
NC score	0.015569 (rank : 270)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	129	Target Neighborhood Hits	1194	Shared Neighborhood Hits	23
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

2A5G_MOUSE
NC score	0.013183 (rank : 271)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	129	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q60996, O35708, Q99KW8, Q99N67, Q99N68	Gene names	Ppp2r5c
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (PP2A, B subunit, B'alpha3 isoform).

2A5G_HUMAN
NC score	0.013175 (rank : 272)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	129	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q13362, Q14391, Q15060, Q15174	Gene names	PPP2R5C, KIAA0044
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (NY-REN-29 antigen).

POF1B_HUMAN
NC score	0.013128 (rank : 273)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	129	Target Neighborhood Hits	494	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

IQEC1_HUMAN
NC score	0.012457 (rank : 274)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	129	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

SF3B2_HUMAN
NC score	0.011053 (rank : 275)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	129	Target Neighborhood Hits	157	Shared Neighborhood Hits	3
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

AXN2_MOUSE
NC score	0.009874 (rank : 276)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	129	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

K0056_HUMAN
NC score	0.009765 (rank : 277)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

HAP1_MOUSE
NC score	0.009731 (rank : 278)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	129	Target Neighborhood Hits	388	Shared Neighborhood Hits	12
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

CA026_HUMAN
NC score	0.008797 (rank : 279)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	129	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T5J6, Q8NEK9, Q9BZQ7, Q9NXQ0	Gene names	C1orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf26.

FOXN4_MOUSE
NC score	0.008120 (rank : 280)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	129	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K3Q3, Q920C0	Gene names	Foxn4
Domain Architecture
Description	Forkhead box protein N4.

DOC10_HUMAN
NC score	0.006313 (rank : 281)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	129	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

MINK1_HUMAN
NC score	0.004796 (rank : 282)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	129	Target Neighborhood Hits	1477	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
NC score	0.003904 (rank : 283)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	129	Target Neighborhood Hits	1451	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

ANGP2_MOUSE
NC score	0.003700 (rank : 284)	θ value	2.36792 (rank : 99)
Query Neighborhood Hits	129	Target Neighborhood Hits	397	Shared Neighborhood Hits	6
SwissProt Accessions	O35608, Q3U1A1, Q9D2D2	Gene names	Angpt2, Agpt2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

E2AK4_HUMAN
NC score	0.002052 (rank : 285)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	129	Target Neighborhood Hits	1012	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

PCOC1_HUMAN
NC score	0.001564 (rank : 286)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	129	Target Neighborhood Hits	146	Shared Neighborhood Hits	3
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

ZN546_HUMAN
NC score	-0.004321 (rank : 287)	θ value	0.62314 (rank : 88)
Query Neighborhood Hits	129	Target Neighborhood Hits	772	Shared Neighborhood Hits	4
SwissProt Accessions	Q86UE3	Gene names	ZNF546, ZNF49
Domain Architecture	No domain graphic available
Description	Zinc finger protein 546.