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Network neighborhood for query Sequence : FYV1_HUMAN

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FYV1_HUMAN
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FYV1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	217	Target Neighborhood Hits	217	Shared Neighborhood Hits	217
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	0 (rank : 2)	NC score	0.990390 (rank : 2)
Query Neighborhood Hits	217	Target Neighborhood Hits	191	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

TCPG_MOUSE
θ value	1.09232e-21 (rank : 3)	NC score	0.319078 (rank : 40)
Query Neighborhood Hits	217	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	P80318	Gene names	Cct3, Cctg
Domain Architecture
Description	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Matricin) (mTRiC-P5).

TCPG_HUMAN
θ value	1.2077e-20 (rank : 4)	NC score	0.316107 (rank : 42)
Query Neighborhood Hits	217	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	P49368, Q5SZY1, Q9BR64	Gene names	CCT3, CCTG, TRIC5
Domain Architecture
Description	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5).

ZFY21_HUMAN
θ value	2.60593e-15 (rank : 5)	NC score	0.623906 (rank : 3)
Query Neighborhood Hits	217	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	1.86753e-13 (rank : 6)	NC score	0.615828 (rank : 4)
Query Neighborhood Hits	217	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	4.16044e-13 (rank : 7)	NC score	0.578991 (rank : 5)
Query Neighborhood Hits	217	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFY16_HUMAN
θ value	2.69671e-12 (rank : 8)	NC score	0.509479 (rank : 8)
Query Neighborhood Hits	217	Target Neighborhood Hits	125	Shared Neighborhood Hits	55
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	1.02475e-11 (rank : 9)	NC score	0.511108 (rank : 7)
Query Neighborhood Hits	217	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

MTMR3_HUMAN
θ value	2.98157e-11 (rank : 10)	NC score	0.331786 (rank : 33)
Query Neighborhood Hits	217	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY1_HUMAN
θ value	3.89403e-11 (rank : 11)	NC score	0.330594 (rank : 34)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	87
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	3.89403e-11 (rank : 12)	NC score	0.333997 (rank : 31)
Query Neighborhood Hits	217	Target Neighborhood Hits	765	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

ZFYV9_HUMAN
θ value	5.08577e-11 (rank : 13)	NC score	0.516728 (rank : 6)
Query Neighborhood Hits	217	Target Neighborhood Hits	134	Shared Neighborhood Hits	60
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

FYCO1_HUMAN
θ value	1.47974e-10 (rank : 14)	NC score	0.245232 (rank : 58)
Query Neighborhood Hits	217	Target Neighborhood Hits	1149	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

PI52A_HUMAN
θ value	2.52405e-10 (rank : 15)	NC score	0.353709 (rank : 25)
Query Neighborhood Hits	217	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P48426, P53807, Q5VUX3	Gene names	PIP5K2A, PIP5K2
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha) (PtdIns(4)P-5-kinase B isoform) (PIP5KIII) (PtdIns(4)P-5-kinase C isoform).

PI52A_MOUSE
θ value	3.29651e-10 (rank : 16)	NC score	0.353079 (rank : 26)
Query Neighborhood Hits	217	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	O70172	Gene names	Pip5k2a
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha).

FYCO1_MOUSE
θ value	3.64472e-09 (rank : 17)	NC score	0.231168 (rank : 64)
Query Neighborhood Hits	217	Target Neighborhood Hits	1059	Shared Neighborhood Hits	90
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ZFYV1_HUMAN
θ value	3.64472e-09 (rank : 18)	NC score	0.479062 (rank : 11)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	6.21693e-09 (rank : 19)	NC score	0.476448 (rank : 12)
Query Neighborhood Hits	217	Target Neighborhood Hits	153	Shared Neighborhood Hits	56
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

FGD6_MOUSE
θ value	1.06045e-08 (rank : 20)	NC score	0.368536 (rank : 23)
Query Neighborhood Hits	217	Target Neighborhood Hits	282	Shared Neighborhood Hits	60
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

TCPW_MOUSE
θ value	1.38499e-08 (rank : 21)	NC score	0.249590 (rank : 57)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q61390, Q9R1U2	Gene names	Cct6b
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (Cctz- 2).

RUFY2_HUMAN
θ value	1.80886e-08 (rank : 22)	NC score	0.259456 (rank : 55)
Query Neighborhood Hits	217	Target Neighborhood Hits	1208	Shared Neighborhood Hits	97
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PI51A_MOUSE
θ value	2.36244e-08 (rank : 23)	NC score	0.323739 (rank : 36)
Query Neighborhood Hits	217	Target Neighborhood Hits	21	Shared Neighborhood Hits	12
SwissProt Accessions	P70182, Q8K0D3, Q99L80	Gene names	Pip5k1a, Pip5k1b
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (Phosphatidylinositol-4-phosphate 5- kinase type I beta) (PI4P5KIbeta) (68 kDa type I phosphatidylinositol- 4-phosphate 5-kinase).

PI51C_MOUSE
θ value	2.36244e-08 (rank : 24)	NC score	0.319890 (rank : 38)
Query Neighborhood Hits	217	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI52B_HUMAN
θ value	5.26297e-08 (rank : 25)	NC score	0.339495 (rank : 30)
Query Neighborhood Hits	217	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P78356, Q5U0E8, Q8TBP2	Gene names	PIP5K2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

PI52B_MOUSE
θ value	5.26297e-08 (rank : 26)	NC score	0.339543 (rank : 29)
Query Neighborhood Hits	217	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XI4, Q8VHB2	Gene names	Pip5k2b
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

RUFY2_MOUSE
θ value	5.26297e-08 (rank : 27)	NC score	0.322268 (rank : 37)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PI51C_HUMAN
θ value	6.87365e-08 (rank : 28)	NC score	0.314778 (rank : 44)
Query Neighborhood Hits	217	Target Neighborhood Hits	109	Shared Neighborhood Hits	17
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

FGD6_HUMAN
θ value	8.97725e-08 (rank : 29)	NC score	0.374256 (rank : 20)
Query Neighborhood Hits	217	Target Neighborhood Hits	237	Shared Neighborhood Hits	61
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PI51B_HUMAN
θ value	8.97725e-08 (rank : 30)	NC score	0.319226 (rank : 39)
Query Neighborhood Hits	217	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	O14986, P78518, P78519, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749	Gene names	PIP5K1B, STM7
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Type I phosphatidylinositol-4-phosphate 5- kinase beta) (Protein STM-7).

WDFY3_HUMAN
θ value	8.97725e-08 (rank : 31)	NC score	0.298552 (rank : 48)
Query Neighborhood Hits	217	Target Neighborhood Hits	348	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	8.97725e-08 (rank : 32)	NC score	0.299497 (rank : 47)
Query Neighborhood Hits	217	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

PKHF2_MOUSE
θ value	1.17247e-07 (rank : 33)	NC score	0.491018 (rank : 9)
Query Neighborhood Hits	217	Target Neighborhood Hits	77	Shared Neighborhood Hits	53
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PI51B_MOUSE
θ value	1.53129e-07 (rank : 34)	NC score	0.317616 (rank : 41)
Query Neighborhood Hits	217	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	P70181, O70335, Q8JZY6	Gene names	Pip5k1b, Pip5k1a
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PIP5KIalpha).

TCPW_HUMAN
θ value	1.53129e-07 (rank : 35)	NC score	0.241597 (rank : 59)
Query Neighborhood Hits	217	Target Neighborhood Hits	29	Shared Neighborhood Hits	13
SwissProt Accessions	Q92526, Q8TC34	Gene names	CCT6B
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (TCP-1- zeta-like) (CCT-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303).

ANFY1_MOUSE
θ value	4.45536e-07 (rank : 36)	NC score	0.205671 (rank : 67)
Query Neighborhood Hits	217	Target Neighborhood Hits	480	Shared Neighborhood Hits	54
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

HGS_MOUSE
θ value	4.45536e-07 (rank : 37)	NC score	0.398473 (rank : 17)
Query Neighborhood Hits	217	Target Neighborhood Hits	589	Shared Neighborhood Hits	76
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

PKHF2_HUMAN
θ value	5.81887e-07 (rank : 38)	NC score	0.485723 (rank : 10)
Query Neighborhood Hits	217	Target Neighborhood Hits	75	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ANFY1_HUMAN
θ value	9.92553e-07 (rank : 39)	NC score	0.203649 (rank : 68)
Query Neighborhood Hits	217	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

HGS_HUMAN
θ value	9.92553e-07 (rank : 40)	NC score	0.398031 (rank : 18)
Query Neighborhood Hits	217	Target Neighborhood Hits	517	Shared Neighborhood Hits	69
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

PI51A_HUMAN
θ value	9.92553e-07 (rank : 41)	NC score	0.312593 (rank : 46)
Query Neighborhood Hits	217	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

RBNS5_HUMAN
θ value	1.29631e-06 (rank : 42)	NC score	0.405111 (rank : 15)
Query Neighborhood Hits	217	Target Neighborhood Hits	242	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	1.29631e-06 (rank : 43)	NC score	0.401430 (rank : 16)
Query Neighborhood Hits	217	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

TCPE_MOUSE
θ value	2.21117e-06 (rank : 44)	NC score	0.239595 (rank : 60)
Query Neighborhood Hits	217	Target Neighborhood Hits	37	Shared Neighborhood Hits	13
SwissProt Accessions	P80316	Gene names	Cct5, Ccte
Domain Architecture
Description	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon).

TCPH_HUMAN
θ value	2.21117e-06 (rank : 45)	NC score	0.239408 (rank : 61)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q99832, O14871	Gene names	CCT7, CCTH, NIP7-1
Domain Architecture
Description	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef- interacting protein).

TCPH_MOUSE
θ value	2.88788e-06 (rank : 46)	NC score	0.238607 (rank : 62)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	P80313	Gene names	Cct7, Ccth
Domain Architecture
Description	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta).

EEA1_MOUSE
θ value	3.77169e-06 (rank : 47)	NC score	0.192289 (rank : 70)
Query Neighborhood Hits	217	Target Neighborhood Hits	1637	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

TCPE_HUMAN
θ value	3.77169e-06 (rank : 48)	NC score	0.238449 (rank : 63)
Query Neighborhood Hits	217	Target Neighborhood Hits	39	Shared Neighborhood Hits	13
SwissProt Accessions	P48643	Gene names	CCT5, CCTE, KIAA0098
Domain Architecture
Description	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon).

EEA1_HUMAN
θ value	4.92598e-06 (rank : 49)	NC score	0.178721 (rank : 71)
Query Neighborhood Hits	217	Target Neighborhood Hits	1796	Shared Neighborhood Hits	103
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

FGD2_HUMAN
θ value	4.92598e-06 (rank : 50)	NC score	0.332409 (rank : 32)
Query Neighborhood Hits	217	Target Neighborhood Hits	151	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
θ value	8.40245e-06 (rank : 51)	NC score	0.313408 (rank : 45)
Query Neighborhood Hits	217	Target Neighborhood Hits	227	Shared Neighborhood Hits	55
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

PKHF1_MOUSE
θ value	8.40245e-06 (rank : 52)	NC score	0.470146 (rank : 13)
Query Neighborhood Hits	217	Target Neighborhood Hits	80	Shared Neighborhood Hits	53
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

FGD4_HUMAN
θ value	1.09739e-05 (rank : 53)	NC score	0.314851 (rank : 43)
Query Neighborhood Hits	217	Target Neighborhood Hits	219	Shared Neighborhood Hits	56
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ZFY27_HUMAN
θ value	1.87187e-05 (rank : 54)	NC score	0.372000 (rank : 22)
Query Neighborhood Hits	217	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

RPGF4_HUMAN
θ value	3.19293e-05 (rank : 55)	NC score	0.119263 (rank : 84)
Query Neighborhood Hits	217	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	3.19293e-05 (rank : 56)	NC score	0.119593 (rank : 83)
Query Neighborhood Hits	217	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

ZFY27_MOUSE
θ value	4.1701e-05 (rank : 57)	NC score	0.367201 (rank : 24)
Query Neighborhood Hits	217	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

PKHF1_HUMAN
θ value	7.1131e-05 (rank : 58)	NC score	0.467032 (rank : 14)
Query Neighborhood Hits	217	Target Neighborhood Hits	76	Shared Neighborhood Hits	55
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

FGD2_MOUSE
θ value	9.29e-05 (rank : 59)	NC score	0.325980 (rank : 35)
Query Neighborhood Hits	217	Target Neighborhood Hits	163	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	0.000121331 (rank : 60)	NC score	0.289472 (rank : 49)
Query Neighborhood Hits	217	Target Neighborhood Hits	249	Shared Neighborhood Hits	59
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

GP155_HUMAN
θ value	0.000121331 (rank : 61)	NC score	0.194045 (rank : 69)
Query Neighborhood Hits	217	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

PREX1_HUMAN
θ value	0.000121331 (rank : 62)	NC score	0.157883 (rank : 79)
Query Neighborhood Hits	217	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ZFY19_HUMAN
θ value	0.00020696 (rank : 63)	NC score	0.378187 (rank : 19)
Query Neighborhood Hits	217	Target Neighborhood Hits	206	Shared Neighborhood Hits	56
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

WDFY1_HUMAN
θ value	0.000461057 (rank : 64)	NC score	0.282828 (rank : 52)
Query Neighborhood Hits	217	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_MOUSE
θ value	0.000786445 (rank : 65)	NC score	0.276785 (rank : 53)
Query Neighborhood Hits	217	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

FGD5_HUMAN
θ value	0.00102713 (rank : 66)	NC score	0.345711 (rank : 28)
Query Neighborhood Hits	217	Target Neighborhood Hits	235	Shared Neighborhood Hits	58
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

WDFY2_HUMAN
θ value	0.00102713 (rank : 67)	NC score	0.273663 (rank : 54)
Query Neighborhood Hits	217	Target Neighborhood Hits	332	Shared Neighborhood Hits	49
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

TCPB_HUMAN
θ value	0.00228821 (rank : 68)	NC score	0.210384 (rank : 65)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P78371, Q6IAT3	Gene names	CCT2, 99D8.1, CCTB
Domain Architecture
Description	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta).

TCPB_MOUSE
θ value	0.00298849 (rank : 69)	NC score	0.209479 (rank : 66)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P80314, Q9R1U0	Gene names	Cct2, Cctb
Domain Architecture
Description	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta).

TGON2_HUMAN
θ value	0.00298849 (rank : 70)	NC score	0.049563 (rank : 185)
Query Neighborhood Hits	217	Target Neighborhood Hits	1037	Shared Neighborhood Hits	40
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ZFY19_MOUSE
θ value	0.00298849 (rank : 71)	NC score	0.372012 (rank : 21)
Query Neighborhood Hits	217	Target Neighborhood Hits	143	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

FGD5_MOUSE
θ value	0.00390308 (rank : 72)	NC score	0.347352 (rank : 27)
Query Neighborhood Hits	217	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

CRF_MOUSE
θ value	0.00665767 (rank : 73)	NC score	0.086528 (rank : 94)
Query Neighborhood Hits	217	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CIT0	Gene names	Crh
Domain Architecture	No domain graphic available
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

CASP_HUMAN
θ value	0.00869519 (rank : 74)	NC score	0.090247 (rank : 91)
Query Neighborhood Hits	217	Target Neighborhood Hits	1131	Shared Neighborhood Hits	59
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_HUMAN
θ value	0.00869519 (rank : 75)	NC score	0.085328 (rank : 95)
Query Neighborhood Hits	217	Target Neighborhood Hits	1574	Shared Neighborhood Hits	63
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CUTL1_MOUSE
θ value	0.0113563 (rank : 76)	NC score	0.086558 (rank : 93)
Query Neighborhood Hits	217	Target Neighborhood Hits	1620	Shared Neighborhood Hits	66
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

FGD1_HUMAN
θ value	0.0148317 (rank : 77)	NC score	0.287545 (rank : 51)
Query Neighborhood Hits	217	Target Neighborhood Hits	367	Shared Neighborhood Hits	57
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	0.0148317 (rank : 78)	NC score	0.287577 (rank : 50)
Query Neighborhood Hits	217	Target Neighborhood Hits	387	Shared Neighborhood Hits	61
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RGS7_HUMAN
θ value	0.0148317 (rank : 79)	NC score	0.074659 (rank : 109)
Query Neighborhood Hits	217	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

RGS7_MOUSE
θ value	0.0148317 (rank : 80)	NC score	0.074941 (rank : 108)
Query Neighborhood Hits	217	Target Neighborhood Hits	79	Shared Neighborhood Hits	12
SwissProt Accessions	O54829	Gene names	Rgs7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

CASP_MOUSE
θ value	0.0252991 (rank : 81)	NC score	0.087297 (rank : 92)
Query Neighborhood Hits	217	Target Neighborhood Hits	1152	Shared Neighborhood Hits	62
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

GCC2_MOUSE
θ value	0.0252991 (rank : 82)	NC score	0.064778 (rank : 121)
Query Neighborhood Hits	217	Target Neighborhood Hits	1619	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

FGD3_MOUSE
θ value	0.0431538 (rank : 83)	NC score	0.249719 (rank : 56)
Query Neighborhood Hits	217	Target Neighborhood Hits	257	Shared Neighborhood Hits	56
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FNBP2_HUMAN
θ value	0.0431538 (rank : 84)	NC score	0.057199 (rank : 146)
Query Neighborhood Hits	217	Target Neighborhood Hits	432	Shared Neighborhood Hits	26
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SRGP1_HUMAN
θ value	0.0431538 (rank : 85)	NC score	0.051043 (rank : 176)
Query Neighborhood Hits	217	Target Neighborhood Hits	390	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

DEPD5_MOUSE
θ value	0.0961366 (rank : 86)	NC score	0.085207 (rank : 96)
Query Neighborhood Hits	217	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

ZMYM3_HUMAN
θ value	0.0961366 (rank : 87)	NC score	0.064100 (rank : 123)
Query Neighborhood Hits	217	Target Neighborhood Hits	223	Shared Neighborhood Hits	12
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ZMYM3_MOUSE
θ value	0.0961366 (rank : 88)	NC score	0.064188 (rank : 122)
Query Neighborhood Hits	217	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

RGS6_HUMAN
θ value	0.125558 (rank : 89)	NC score	0.069081 (rank : 113)
Query Neighborhood Hits	217	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

RGS6_MOUSE
θ value	0.125558 (rank : 90)	NC score	0.066968 (rank : 119)
Query Neighborhood Hits	217	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

SLK_HUMAN
θ value	0.125558 (rank : 91)	NC score	0.017618 (rank : 246)
Query Neighborhood Hits	217	Target Neighborhood Hits	1775	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

DEPD5_HUMAN
θ value	0.163984 (rank : 92)	NC score	0.084026 (rank : 99)
Query Neighborhood Hits	217	Target Neighborhood Hits	40	Shared Neighborhood Hits	14
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

MYH10_HUMAN
θ value	0.163984 (rank : 93)	NC score	0.046166 (rank : 192)
Query Neighborhood Hits	217	Target Neighborhood Hits	1620	Shared Neighborhood Hits	68
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

DVL3_HUMAN
θ value	0.21417 (rank : 94)	NC score	0.057375 (rank : 144)
Query Neighborhood Hits	217	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.21417 (rank : 95)	NC score	0.055836 (rank : 153)
Query Neighborhood Hits	217	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

RPGF5_MOUSE
θ value	0.21417 (rank : 96)	NC score	0.083362 (rank : 102)
Query Neighborhood Hits	217	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

ZYX_HUMAN
θ value	0.21417 (rank : 97)	NC score	0.015701 (rank : 259)
Query Neighborhood Hits	217	Target Neighborhood Hits	387	Shared Neighborhood Hits	8
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

ZNF70_HUMAN
θ value	0.279714 (rank : 98)	NC score	-0.000225 (rank : 294)
Query Neighborhood Hits	217	Target Neighborhood Hits	760	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

MYH10_MOUSE
θ value	0.365318 (rank : 99)	NC score	0.045513 (rank : 193)
Query Neighborhood Hits	217	Target Neighborhood Hits	1612	Shared Neighborhood Hits	67
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

SOCS5_MOUSE
θ value	0.365318 (rank : 100)	NC score	0.024436 (rank : 228)
Query Neighborhood Hits	217	Target Neighborhood Hits	93	Shared Neighborhood Hits	3
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SPTN5_HUMAN
θ value	0.365318 (rank : 101)	NC score	0.049656 (rank : 184)
Query Neighborhood Hits	217	Target Neighborhood Hits	674	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

ANR11_HUMAN
θ value	0.47712 (rank : 102)	NC score	0.024451 (rank : 227)
Query Neighborhood Hits	217	Target Neighborhood Hits	1289	Shared Neighborhood Hits	41
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

SLK_MOUSE
θ value	0.47712 (rank : 103)	NC score	0.016432 (rank : 253)
Query Neighborhood Hits	217	Target Neighborhood Hits	1798	Shared Neighborhood Hits	55
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

CTDP1_HUMAN
θ value	0.62314 (rank : 104)	NC score	0.047567 (rank : 189)
Query Neighborhood Hits	217	Target Neighborhood Hits	416	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DSPP_HUMAN
θ value	0.62314 (rank : 105)	NC score	0.044762 (rank : 195)
Query Neighborhood Hits	217	Target Neighborhood Hits	645	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

BPTF_HUMAN
θ value	0.813845 (rank : 106)	NC score	0.029506 (rank : 217)
Query Neighborhood Hits	217	Target Neighborhood Hits	786	Shared Neighborhood Hits	35
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

DSPP_MOUSE
θ value	0.813845 (rank : 107)	NC score	0.044667 (rank : 196)
Query Neighborhood Hits	217	Target Neighborhood Hits	491	Shared Neighborhood Hits	29
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

KKCC2_MOUSE
θ value	0.813845 (rank : 108)	NC score	0.000636 (rank : 291)
Query Neighborhood Hits	217	Target Neighborhood Hits	855	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

RNF34_MOUSE
θ value	0.813845 (rank : 109)	NC score	0.116589 (rank : 86)
Query Neighborhood Hits	217	Target Neighborhood Hits	160	Shared Neighborhood Hits	34
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

SNX23_HUMAN
θ value	0.813845 (rank : 110)	NC score	0.034789 (rank : 206)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	52
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

APOA4_MOUSE
θ value	1.06291 (rank : 111)	NC score	0.045183 (rank : 194)
Query Neighborhood Hits	217	Target Neighborhood Hits	435	Shared Neighborhood Hits	27
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

TRIO_HUMAN
θ value	1.06291 (rank : 112)	NC score	0.032459 (rank : 207)
Query Neighborhood Hits	217	Target Neighborhood Hits	1580	Shared Neighborhood Hits	56
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ZCH10_HUMAN
θ value	1.38821 (rank : 113)	NC score	0.039784 (rank : 203)
Query Neighborhood Hits	217	Target Neighborhood Hits	123	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

BAZ2B_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.027903 (rank : 218)
Query Neighborhood Hits	217	Target Neighborhood Hits	803	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

CAC1I_HUMAN
θ value	1.81305 (rank : 115)	NC score	0.010852 (rank : 277)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

FREA_MOUSE
θ value	1.81305 (rank : 116)	NC score	0.006533 (rank : 287)
Query Neighborhood Hits	217	Target Neighborhood Hits	147	Shared Neighborhood Hits	5
SwissProt Accessions	Q61574, Q8C5N7	Gene names	Fkhl18, Fkh3, Freac10
Domain Architecture	No domain graphic available
Description	Forkhead-related transcription factor 10 (FREAC-10) (Forkhead-like 18 protein) (Transcription factor FKH-3).

INVO_HUMAN
θ value	1.81305 (rank : 117)	NC score	0.060384 (rank : 131)
Query Neighborhood Hits	217	Target Neighborhood Hits	636	Shared Neighborhood Hits	43
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

MYH11_HUMAN
θ value	1.81305 (rank : 118)	NC score	0.043827 (rank : 198)
Query Neighborhood Hits	217	Target Neighborhood Hits	1806	Shared Neighborhood Hits	65
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

SH3G2_HUMAN
θ value	1.81305 (rank : 119)	NC score	0.029694 (rank : 216)
Query Neighborhood Hits	217	Target Neighborhood Hits	324	Shared Neighborhood Hits	23
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	1.81305 (rank : 120)	NC score	0.027734 (rank : 219)
Query Neighborhood Hits	217	Target Neighborhood Hits	319	Shared Neighborhood Hits	22
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SOX6_HUMAN
θ value	1.81305 (rank : 121)	NC score	0.027042 (rank : 222)
Query Neighborhood Hits	217	Target Neighborhood Hits	332	Shared Neighborhood Hits	21
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

SOX6_MOUSE
θ value	1.81305 (rank : 122)	NC score	0.027266 (rank : 221)
Query Neighborhood Hits	217	Target Neighborhood Hits	341	Shared Neighborhood Hits	23
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

UBXD7_HUMAN
θ value	1.81305 (rank : 123)	NC score	0.022983 (rank : 229)
Query Neighborhood Hits	217	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	O94888, Q6ZP77, Q86X20, Q8N327	Gene names	UBXD7, KIAA0794
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 7.

ARP5_MOUSE
θ value	2.36792 (rank : 124)	NC score	0.031077 (rank : 210)
Query Neighborhood Hits	217	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	Q80US4, Q8BL26	Gene names	Actr5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5.

CHD4_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.010947 (rank : 276)
Query Neighborhood Hits	217	Target Neighborhood Hits	365	Shared Neighborhood Hits	16
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	2.36792 (rank : 126)	NC score	0.016678 (rank : 251)
Query Neighborhood Hits	217	Target Neighborhood Hits	408	Shared Neighborhood Hits	19
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

DMP1_HUMAN
θ value	2.36792 (rank : 127)	NC score	0.030525 (rank : 213)
Query Neighborhood Hits	217	Target Neighborhood Hits	491	Shared Neighborhood Hits	26
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

MYCPP_HUMAN
θ value	2.36792 (rank : 128)	NC score	0.016210 (rank : 255)
Query Neighborhood Hits	217	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z401, Q14655, Q86T77, Q8IVX2, Q8NB93	Gene names	MYCPBP, IRLB
Domain Architecture	No domain graphic available
Description	C-myc promoter-binding protein.

NEK1_MOUSE
θ value	2.36792 (rank : 129)	NC score	0.003325 (rank : 289)
Query Neighborhood Hits	217	Target Neighborhood Hits	1311	Shared Neighborhood Hits	37
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

RNF34_HUMAN
θ value	2.36792 (rank : 130)	NC score	0.105527 (rank : 88)
Query Neighborhood Hits	217	Target Neighborhood Hits	153	Shared Neighborhood Hits	31
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

SPTA1_HUMAN
θ value	2.36792 (rank : 131)	NC score	0.047135 (rank : 190)
Query Neighborhood Hits	217	Target Neighborhood Hits	748	Shared Neighborhood Hits	47
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

YLPM1_HUMAN
θ value	2.36792 (rank : 132)	NC score	0.022240 (rank : 232)
Query Neighborhood Hits	217	Target Neighborhood Hits	670	Shared Neighborhood Hits	26
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZN507_HUMAN
θ value	2.36792 (rank : 133)	NC score	0.003002 (rank : 290)
Query Neighborhood Hits	217	Target Neighborhood Hits	739	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

ARP5_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.027550 (rank : 220)
Query Neighborhood Hits	217	Target Neighborhood Hits	107	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H9F9, Q86WF7, Q8IUY5, Q8N724, Q9BRN0, Q9BVB7	Gene names	ACTR5, ARP5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16).

ATX2L_HUMAN
θ value	3.0926 (rank : 135)	NC score	0.021005 (rank : 235)
Query Neighborhood Hits	217	Target Neighborhood Hits	443	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

K1HB_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.021621 (rank : 233)
Query Neighborhood Hits	217	Target Neighborhood Hits	470	Shared Neighborhood Hits	33
SwissProt Accessions	Q14525, O76010	Gene names	KRTHA3B, HHA3-II, HKA3B
Domain Architecture
Description	Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II).

KNTC2_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.051465 (rank : 172)
Query Neighborhood Hits	217	Target Neighborhood Hits	673	Shared Neighborhood Hits	41
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

LRC50_MOUSE
θ value	3.0926 (rank : 138)	NC score	0.025551 (rank : 226)
Query Neighborhood Hits	217	Target Neighborhood Hits	190	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D2H9, Q9CVS9	Gene names	Lrrc50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

MYH11_MOUSE
θ value	3.0926 (rank : 139)	NC score	0.043143 (rank : 199)
Query Neighborhood Hits	217	Target Neighborhood Hits	1777	Shared Neighborhood Hits	67
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PASK_MOUSE
θ value	3.0926 (rank : 140)	NC score	0.000305 (rank : 293)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PAX8_HUMAN
θ value	3.0926 (rank : 141)	NC score	0.008538 (rank : 282)
Query Neighborhood Hits	217	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q06710, Q09155, Q16337, Q16338, Q16339, Q96J49	Gene names	PAX8
Domain Architecture
Description	Paired box protein Pax-8.

PCLO_HUMAN
θ value	3.0926 (rank : 142)	NC score	0.019024 (rank : 240)
Query Neighborhood Hits	217	Target Neighborhood Hits	2046	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SL9A3_HUMAN
θ value	3.0926 (rank : 143)	NC score	0.019131 (rank : 239)
Query Neighborhood Hits	217	Target Neighborhood Hits	63	Shared Neighborhood Hits	7
SwissProt Accessions	P48764	Gene names	SLC9A3, NHE3
Domain Architecture
Description	Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3).

UB7I4_MOUSE
θ value	3.0926 (rank : 144)	NC score	0.026320 (rank : 223)
Query Neighborhood Hits	217	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

VCAM1_MOUSE
θ value	3.0926 (rank : 145)	NC score	0.010734 (rank : 278)
Query Neighborhood Hits	217	Target Neighborhood Hits	320	Shared Neighborhood Hits	5
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

WDHD1_MOUSE
θ value	3.0926 (rank : 146)	NC score	0.012883 (rank : 268)
Query Neighborhood Hits	217	Target Neighborhood Hits	414	Shared Neighborhood Hits	15
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

AFF4_MOUSE
θ value	4.03905 (rank : 147)	NC score	0.017937 (rank : 245)
Query Neighborhood Hits	217	Target Neighborhood Hits	581	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

AKAP2_HUMAN
θ value	4.03905 (rank : 148)	NC score	0.030872 (rank : 211)
Query Neighborhood Hits	217	Target Neighborhood Hits	507	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

BCAR1_HUMAN
θ value	4.03905 (rank : 149)	NC score	0.015750 (rank : 258)
Query Neighborhood Hits	217	Target Neighborhood Hits	554	Shared Neighborhood Hits	25
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DCP1A_HUMAN
θ value	4.03905 (rank : 150)	NC score	0.015356 (rank : 261)
Query Neighborhood Hits	217	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

DCTN4_MOUSE
θ value	4.03905 (rank : 151)	NC score	0.016964 (rank : 250)
Query Neighborhood Hits	217	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CBY8, Q923A0, Q9D4X0	Gene names	Dctn4
Domain Architecture	No domain graphic available
Description	Dynactin subunit 4 (Dynactin subunit p62).

DDX21_MOUSE
θ value	4.03905 (rank : 152)	NC score	0.012455 (rank : 271)
Query Neighborhood Hits	217	Target Neighborhood Hits	350	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DYH5_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.017375 (rank : 247)
Query Neighborhood Hits	217	Target Neighborhood Hits	323	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

LIMA1_MOUSE
θ value	4.03905 (rank : 154)	NC score	0.012086 (rank : 274)
Query Neighborhood Hits	217	Target Neighborhood Hits	298	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ERG0, Q9ERG1	Gene names	Lima1, D15Ertd366e, Eplin
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN).

MY18A_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.049008 (rank : 187)
Query Neighborhood Hits	217	Target Neighborhood Hits	1929	Shared Neighborhood Hits	88
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NOC2L_HUMAN
θ value	4.03905 (rank : 156)	NC score	0.025699 (rank : 225)
Query Neighborhood Hits	217	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3T9, Q5SVA3, Q9BTN6	Gene names	NOC2L
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

PTPRG_HUMAN
θ value	4.03905 (rank : 157)	NC score	0.003816 (rank : 288)
Query Neighborhood Hits	217	Target Neighborhood Hits	231	Shared Neighborhood Hits	11
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

SAP_HUMAN
θ value	4.03905 (rank : 158)	NC score	0.025706 (rank : 224)
Query Neighborhood Hits	217	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	P07602, P07292, P15793, P78538, P78541, P78546, P78547, P78558, Q6IBQ6, Q92739, Q92740, Q92741, Q92742	Gene names	PSAP
Domain Architecture
Description	Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)].

SPTB2_HUMAN
θ value	4.03905 (rank : 159)	NC score	0.040229 (rank : 201)
Query Neighborhood Hits	217	Target Neighborhood Hits	748	Shared Neighborhood Hits	43
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

STON2_HUMAN
θ value	4.03905 (rank : 160)	NC score	0.012816 (rank : 269)
Query Neighborhood Hits	217	Target Neighborhood Hits	115	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

UB7I4_HUMAN
θ value	4.03905 (rank : 161)	NC score	0.022377 (rank : 231)
Query Neighborhood Hits	217	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

AFF4_HUMAN
θ value	5.27518 (rank : 162)	NC score	0.018346 (rank : 244)
Query Neighborhood Hits	217	Target Neighborhood Hits	611	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

AIM1_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.015810 (rank : 257)
Query Neighborhood Hits	217	Target Neighborhood Hits	247	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

ANKS6_HUMAN
θ value	5.27518 (rank : 164)	NC score	0.010344 (rank : 279)
Query Neighborhood Hits	217	Target Neighborhood Hits	411	Shared Neighborhood Hits	6
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

BRD3_HUMAN
θ value	5.27518 (rank : 165)	NC score	0.016416 (rank : 254)
Query Neighborhood Hits	217	Target Neighborhood Hits	369	Shared Neighborhood Hits	25
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

CI037_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.022430 (rank : 230)
Query Neighborhood Hits	217	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2J1, Q5T368	Gene names	C9orf37
Domain Architecture	No domain graphic available
Description	Protein C9orf37.

DVL2_MOUSE
θ value	5.27518 (rank : 167)	NC score	0.035633 (rank : 204)
Query Neighborhood Hits	217	Target Neighborhood Hits	233	Shared Neighborhood Hits	20
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

F125A_MOUSE
θ value	5.27518 (rank : 168)	NC score	0.014638 (rank : 263)
Query Neighborhood Hits	217	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q78HU3	Gene names	Fam125a
Domain Architecture	No domain graphic available
Description	Protein FAM125A.

GOGA5_HUMAN
θ value	5.27518 (rank : 169)	NC score	0.056368 (rank : 150)
Query Neighborhood Hits	217	Target Neighborhood Hits	1168	Shared Neighborhood Hits	55
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

HOOK2_MOUSE
θ value	5.27518 (rank : 170)	NC score	0.044505 (rank : 197)
Query Neighborhood Hits	217	Target Neighborhood Hits	736	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

RERE_HUMAN
θ value	5.27518 (rank : 171)	NC score	0.012896 (rank : 267)
Query Neighborhood Hits	217	Target Neighborhood Hits	779	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SI1L2_HUMAN
θ value	5.27518 (rank : 172)	NC score	0.012252 (rank : 272)
Query Neighborhood Hits	217	Target Neighborhood Hits	131	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

TRI32_HUMAN
θ value	5.27518 (rank : 173)	NC score	0.018836 (rank : 241)
Query Neighborhood Hits	217	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	5.27518 (rank : 174)	NC score	0.018512 (rank : 243)
Query Neighborhood Hits	217	Target Neighborhood Hits	271	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

WDR34_HUMAN
θ value	5.27518 (rank : 175)	NC score	0.015954 (rank : 256)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	4
SwissProt Accessions	Q96EX3, Q5VXV4, Q9BV46	Gene names	WDR34
Domain Architecture
Description	WD repeat protein 34.

ZCPW1_HUMAN
θ value	5.27518 (rank : 176)	NC score	0.015688 (rank : 260)
Query Neighborhood Hits	217	Target Neighborhood Hits	116	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

ZO2_MOUSE
θ value	5.27518 (rank : 177)	NC score	0.012637 (rank : 270)
Query Neighborhood Hits	217	Target Neighborhood Hits	296	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

CP250_MOUSE
θ value	6.88961 (rank : 178)	NC score	0.049172 (rank : 186)
Query Neighborhood Hits	217	Target Neighborhood Hits	1583	Shared Neighborhood Hits	63
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

DMD_MOUSE
θ value	6.88961 (rank : 179)	NC score	0.049917 (rank : 183)
Query Neighborhood Hits	217	Target Neighborhood Hits	1111	Shared Neighborhood Hits	57
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DVL2_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.034946 (rank : 205)
Query Neighborhood Hits	217	Target Neighborhood Hits	223	Shared Neighborhood Hits	19
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

GMIP_MOUSE
θ value	6.88961 (rank : 181)	NC score	0.017287 (rank : 249)
Query Neighborhood Hits	217	Target Neighborhood Hits	202	Shared Neighborhood Hits	17
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

MBB1A_MOUSE
θ value	6.88961 (rank : 182)	NC score	0.021193 (rank : 234)
Query Neighborhood Hits	217	Target Neighborhood Hits	233	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

MCPH1_MOUSE
θ value	6.88961 (rank : 183)	NC score	0.012117 (rank : 273)
Query Neighborhood Hits	217	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

MY18A_MOUSE
θ value	6.88961 (rank : 184)	NC score	0.048280 (rank : 188)
Query Neighborhood Hits	217	Target Neighborhood Hits	1989	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NCOAT_MOUSE
θ value	6.88961 (rank : 185)	NC score	0.011901 (rank : 275)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQQ9, Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7	Gene names	Mgea5, Hexc, Kiaa0679
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

NRIP1_HUMAN
θ value	6.88961 (rank : 186)	NC score	0.016548 (rank : 252)
Query Neighborhood Hits	217	Target Neighborhood Hits	88	Shared Neighborhood Hits	11
SwissProt Accessions	P48552, Q8IWE8	Gene names	NRIP1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

OXSR1_HUMAN
θ value	6.88961 (rank : 187)	NC score	-0.001743 (rank : 296)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PELP1_MOUSE
θ value	6.88961 (rank : 188)	NC score	0.020682 (rank : 236)
Query Neighborhood Hits	217	Target Neighborhood Hits	709	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PLCB3_MOUSE
θ value	6.88961 (rank : 189)	NC score	0.013906 (rank : 265)
Query Neighborhood Hits	217	Target Neighborhood Hits	344	Shared Neighborhood Hits	27
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PRGC2_HUMAN
θ value	6.88961 (rank : 190)	NC score	0.010120 (rank : 280)
Query Neighborhood Hits	217	Target Neighborhood Hits	272	Shared Neighborhood Hits	9
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

SET1A_HUMAN
θ value	6.88961 (rank : 191)	NC score	0.014274 (rank : 264)
Query Neighborhood Hits	217	Target Neighborhood Hits	690	Shared Neighborhood Hits	26
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SOX12_HUMAN
θ value	6.88961 (rank : 192)	NC score	0.006909 (rank : 286)
Query Neighborhood Hits	217	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	O15370, Q9NUD4	Gene names	SOX12, SOX22
Domain Architecture
Description	SOX-12 protein (SOX-22 protein).

STAU1_HUMAN
θ value	6.88961 (rank : 193)	NC score	0.009053 (rank : 281)
Query Neighborhood Hits	217	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	O95793, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2	Gene names	STAU1, STAU
Domain Architecture
Description	Double-stranded RNA-binding protein Staufen homolog 1.

TITIN_HUMAN
θ value	6.88961 (rank : 194)	NC score	0.000441 (rank : 292)
Query Neighborhood Hits	217	Target Neighborhood Hits	2923	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

UBF1_MOUSE
θ value	6.88961 (rank : 195)	NC score	0.017374 (rank : 248)
Query Neighborhood Hits	217	Target Neighborhood Hits	419	Shared Neighborhood Hits	29
SwissProt Accessions	P25976	Gene names	Ubtf, Tcfubf, Ubf-1, Ubf1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1).

UBP34_HUMAN
θ value	6.88961 (rank : 196)	NC score	0.006966 (rank : 285)
Query Neighborhood Hits	217	Target Neighborhood Hits	210	Shared Neighborhood Hits	10
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UN84B_HUMAN
θ value	6.88961 (rank : 197)	NC score	0.018751 (rank : 242)
Query Neighborhood Hits	217	Target Neighborhood Hits	172	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UH99, O75156, Q6B4H1, Q7Z3E3	Gene names	UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2
Domain Architecture	No domain graphic available
Description	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP).

ZN434_HUMAN
θ value	6.88961 (rank : 198)	NC score	-0.004121 (rank : 298)
Query Neighborhood Hits	217	Target Neighborhood Hits	747	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NX65, Q7Z6G2	Gene names	ZNF434
Domain Architecture
Description	Zinc finger protein 434.

ZN483_HUMAN
θ value	6.88961 (rank : 199)	NC score	-0.004261 (rank : 299)
Query Neighborhood Hits	217	Target Neighborhood Hits	785	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TF39	Gene names	ZNF483, KIAA1962
Domain Architecture
Description	Zinc finger protein 483.

CDC37_MOUSE
θ value	8.99809 (rank : 200)	NC score	0.019564 (rank : 238)
Query Neighborhood Hits	217	Target Neighborhood Hits	359	Shared Neighborhood Hits	21
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

DVL1L_HUMAN
θ value	8.99809 (rank : 201)	NC score	0.029779 (rank : 215)
Query Neighborhood Hits	217	Target Neighborhood Hits	146	Shared Neighborhood Hits	17
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_MOUSE
θ value	8.99809 (rank : 202)	NC score	0.030214 (rank : 214)
Query Neighborhood Hits	217	Target Neighborhood Hits	146	Shared Neighborhood Hits	16
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

LAMB1_HUMAN
θ value	8.99809 (rank : 203)	NC score	0.019944 (rank : 237)
Query Neighborhood Hits	217	Target Neighborhood Hits	1018	Shared Neighborhood Hits	41
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

MYRIP_HUMAN
θ value	8.99809 (rank : 204)	NC score	0.031460 (rank : 208)
Query Neighborhood Hits	217	Target Neighborhood Hits	269	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NEMO_MOUSE
θ value	8.99809 (rank : 205)	NC score	0.041972 (rank : 200)
Query Neighborhood Hits	217	Target Neighborhood Hits	658	Shared Neighborhood Hits	35
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

NRDC_MOUSE
θ value	8.99809 (rank : 206)	NC score	0.007100 (rank : 284)
Query Neighborhood Hits	217	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

PTN23_HUMAN
θ value	8.99809 (rank : 207)	NC score	0.013149 (rank : 266)
Query Neighborhood Hits	217	Target Neighborhood Hits	646	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

R3HD1_HUMAN
θ value	8.99809 (rank : 208)	NC score	0.015187 (rank : 262)
Query Neighborhood Hits	217	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

SFRS4_HUMAN
θ value	8.99809 (rank : 209)	NC score	0.007824 (rank : 283)
Query Neighborhood Hits	217	Target Neighborhood Hits	384	Shared Neighborhood Hits	14
SwissProt Accessions	Q08170, Q5VXP1, Q9BUA4, Q9UEB5	Gene names	SFRS4, SRP75
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB).

SPTB2_MOUSE
θ value	8.99809 (rank : 210)	NC score	0.040028 (rank : 202)
Query Neighborhood Hits	217	Target Neighborhood Hits	770	Shared Neighborhood Hits	46
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SRGP2_HUMAN
θ value	8.99809 (rank : 211)	NC score	0.030735 (rank : 212)
Query Neighborhood Hits	217	Target Neighborhood Hits	331	Shared Neighborhood Hits	21
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	8.99809 (rank : 212)	NC score	0.031211 (rank : 209)
Query Neighborhood Hits	217	Target Neighborhood Hits	324	Shared Neighborhood Hits	23
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SWP70_HUMAN
θ value	8.99809 (rank : 213)	NC score	0.063682 (rank : 125)
Query Neighborhood Hits	217	Target Neighborhood Hits	973	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	8.99809 (rank : 214)	NC score	0.060201 (rank : 134)
Query Neighborhood Hits	217	Target Neighborhood Hits	1097	Shared Neighborhood Hits	64
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYNE1_HUMAN
θ value	8.99809 (rank : 215)	NC score	0.046296 (rank : 191)
Query Neighborhood Hits	217	Target Neighborhood Hits	1484	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ZN323_HUMAN
θ value	8.99809 (rank : 216)	NC score	-0.000458 (rank : 295)
Query Neighborhood Hits	217	Target Neighborhood Hits	802	Shared Neighborhood Hits	19
SwissProt Accessions	Q96LW9, Q8WWS5	Gene names	ZNF323
Domain Architecture
Description	Zinc finger protein 323.

ZNF8_HUMAN
θ value	8.99809 (rank : 217)	NC score	-0.003461 (rank : 297)
Query Neighborhood Hits	217	Target Neighborhood Hits	748	Shared Neighborhood Hits	9
SwissProt Accessions	P17098, Q6PI99	Gene names	ZNF8
Domain Architecture	No domain graphic available
Description	Zinc finger protein 8 (Zinc finger protein HF.18).

ABR_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.058942 (rank : 139)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.050518 (rank : 178)
Query Neighborhood Hits	217	Target Neighborhood Hits	176	Shared Neighborhood Hits	18
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.050323 (rank : 180)
Query Neighborhood Hits	217	Target Neighborhood Hits	266	Shared Neighborhood Hits	21
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.056163 (rank : 151)
Query Neighborhood Hits	217	Target Neighborhood Hits	120	Shared Neighborhood Hits	15
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG4_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.061424 (rank : 129)
Query Neighborhood Hits	217	Target Neighborhood Hits	242	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.059907 (rank : 137)
Query Neighborhood Hits	217	Target Neighborhood Hits	185	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.068102 (rank : 116)
Query Neighborhood Hits	217	Target Neighborhood Hits	172	Shared Neighborhood Hits	17
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG9_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.057466 (rank : 143)
Query Neighborhood Hits	217	Target Neighborhood Hits	235	Shared Neighborhood Hits	22
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.056873 (rank : 148)
Query Neighborhood Hits	217	Target Neighborhood Hits	234	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.066673 (rank : 120)
Query Neighborhood Hits	217	Target Neighborhood Hits	187	Shared Neighborhood Hits	18
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.067737 (rank : 117)
Query Neighborhood Hits	217	Target Neighborhood Hits	125	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGF_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.060220 (rank : 133)
Query Neighborhood Hits	217	Target Neighborhood Hits	214	Shared Neighborhood Hits	16
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.059950 (rank : 136)
Query Neighborhood Hits	217	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.055774 (rank : 154)
Query Neighborhood Hits	217	Target Neighborhood Hits	152	Shared Neighborhood Hits	17
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BBS10_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.070132 (rank : 112)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TAM1, Q96CW2, Q9H5D2	Gene names	BBS10, C12orf58
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein.

BBS10_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.058305 (rank : 140)
Query Neighborhood Hits	217	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBI2	Gene names	Bbs10
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein homolog.

BCR_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.060426 (rank : 130)
Query Neighborhood Hits	217	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CARD9_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.050324 (rank : 179)
Query Neighborhood Hits	217	Target Neighborhood Hits	602	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CCD21_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.051636 (rank : 170)
Query Neighborhood Hits	217	Target Neighborhood Hits	1228	Shared Neighborhood Hits	59
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCDC6_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.057130 (rank : 147)
Query Neighborhood Hits	217	Target Neighborhood Hits	723	Shared Neighborhood Hits	44
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CCHCR_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.052756 (rank : 162)
Query Neighborhood Hits	217	Target Neighborhood Hits	932	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CE290_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.053155 (rank : 159)
Query Neighborhood Hits	217	Target Neighborhood Hits	1553	Shared Neighborhood Hits	59
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CEP63_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.052858 (rank : 161)
Query Neighborhood Hits	217	Target Neighborhood Hits	1005	Shared Neighborhood Hits	57
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CF182_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.051961 (rank : 167)
Query Neighborhood Hits	217	Target Neighborhood Hits	551	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

CH60_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.104492 (rank : 89)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P10809	Gene names	HSPD1, HSP60
Domain Architecture
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60).

CH60_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.111957 (rank : 87)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	P63038, P19226, P19227, P97602	Gene names	Hspd1, Hsp60
Domain Architecture	No domain graphic available
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (HSP-65).

CJ064_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.068730 (rank : 114)
Query Neighborhood Hits	217	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

CNTRB_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.051746 (rank : 169)
Query Neighborhood Hits	217	Target Neighborhood Hits	1029	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP135_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.051624 (rank : 171)
Query Neighborhood Hits	217	Target Neighborhood Hits	1290	Shared Neighborhood Hits	55
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP250_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.050019 (rank : 182)
Query Neighborhood Hits	217	Target Neighborhood Hits	1805	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CUTL2_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.053846 (rank : 156)
Query Neighborhood Hits	217	Target Neighborhood Hits	906	Shared Neighborhood Hits	44
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CUTL2_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.057278 (rank : 145)
Query Neighborhood Hits	217	Target Neighborhood Hits	771	Shared Neighborhood Hits	35
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

ECT2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.077955 (rank : 107)
Query Neighborhood Hits	217	Target Neighborhood Hits	98	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.079842 (rank : 105)
Query Neighborhood Hits	217	Target Neighborhood Hits	98	Shared Neighborhood Hits	15
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP1_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.083016 (rank : 103)
Query Neighborhood Hits	217	Target Neighborhood Hits	241	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.085097 (rank : 97)
Query Neighborhood Hits	217	Target Neighborhood Hits	240	Shared Neighborhood Hits	23
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.083850 (rank : 101)
Query Neighborhood Hits	217	Target Neighborhood Hits	209	Shared Neighborhood Hits	18
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GCC2_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.051364 (rank : 175)
Query Neighborhood Hits	217	Target Neighborhood Hits	1558	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GNRP_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.070219 (rank : 111)
Query Neighborhood Hits	217	Target Neighborhood Hits	239	Shared Neighborhood Hits	31
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.068393 (rank : 115)
Query Neighborhood Hits	217	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GOGA1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.054601 (rank : 155)
Query Neighborhood Hits	217	Target Neighborhood Hits	1222	Shared Neighborhood Hits	62
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.052263 (rank : 165)
Query Neighborhood Hits	217	Target Neighborhood Hits	994	Shared Neighborhood Hits	52
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA2_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.053333 (rank : 158)
Query Neighborhood Hits	217	Target Neighborhood Hits	856	Shared Neighborhood Hits	51
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

GOGA2_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.051945 (rank : 168)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	46
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

GOGA3_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.052621 (rank : 164)
Query Neighborhood Hits	217	Target Neighborhood Hits	1317	Shared Neighborhood Hits	59
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA3_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.056151 (rank : 152)
Query Neighborhood Hits	217	Target Neighborhood Hits	1437	Shared Neighborhood Hits	67
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GOGA5_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.057661 (rank : 142)
Query Neighborhood Hits	217	Target Neighborhood Hits	1434	Shared Neighborhood Hits	67
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

HAPIP_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.084771 (rank : 98)
Query Neighborhood Hits	217	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ITSN1_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.060311 (rank : 132)
Query Neighborhood Hits	217	Target Neighborhood Hits	1757	Shared Neighborhood Hits	69
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.060137 (rank : 135)
Query Neighborhood Hits	217	Target Neighborhood Hits	1669	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.057890 (rank : 141)
Query Neighborhood Hits	217	Target Neighborhood Hits	1173	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.059281 (rank : 138)
Query Neighborhood Hits	217	Target Neighborhood Hits	1371	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

KTN1_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.051417 (rank : 173)
Query Neighborhood Hits	217	Target Neighborhood Hits	1324	Shared Neighborhood Hits	57
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LBC_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.050795 (rank : 177)
Query Neighborhood Hits	217	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MCF2L_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.067415 (rank : 118)
Query Neighborhood Hits	217	Target Neighborhood Hits	255	Shared Neighborhood Hits	32
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.063939 (rank : 124)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	26
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MD1L1_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.052208 (rank : 166)
Query Neighborhood Hits	217	Target Neighborhood Hits	1001	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MKKS_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.078580 (rank : 106)
Query Neighborhood Hits	217	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NPJ1	Gene names	MKKS
Domain Architecture
Description	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Bardet- Biedl syndrome 6 protein).

MKKS_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.096214 (rank : 90)
Query Neighborhood Hits	217	Target Neighborhood Hits	25	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JI70	Gene names	Mkks
Domain Architecture
Description	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.

NGEF_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.062409 (rank : 126)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.061486 (rank : 128)
Query Neighborhood Hits	217	Target Neighborhood Hits	228	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHG1_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.072713 (rank : 110)
Query Neighborhood Hits	217	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.062342 (rank : 127)
Query Neighborhood Hits	217	Target Neighborhood Hits	200	Shared Neighborhood Hits	18
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

RABE1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.052719 (rank : 163)
Query Neighborhood Hits	217	Target Neighborhood Hits	1104	Shared Neighborhood Hits	55
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE2_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.053115 (rank : 160)
Query Neighborhood Hits	217	Target Neighborhood Hits	545	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RABE2_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.056464 (rank : 149)
Query Neighborhood Hits	217	Target Neighborhood Hits	598	Shared Neighborhood Hits	38
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RB6I2_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.050273 (rank : 181)
Query Neighborhood Hits	217	Target Neighborhood Hits	1433	Shared Neighborhood Hits	55
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RBP24_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.051384 (rank : 174)
Query Neighborhood Hits	217	Target Neighborhood Hits	1559	Shared Neighborhood Hits	64
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RFFL_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.081980 (rank : 104)
Query Neighborhood Hits	217	Target Neighborhood Hits	175	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.083937 (rank : 100)
Query Neighborhood Hits	217	Target Neighborhood Hits	145	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RUFY3_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.118590 (rank : 85)
Query Neighborhood Hits	217	Target Neighborhood Hits	594	Shared Neighborhood Hits	32
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.120188 (rank : 82)
Query Neighborhood Hits	217	Target Neighborhood Hits	579	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

TCPA1_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.158155 (rank : 77)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P11984	Gene names	Cct1, Ccta, Tcp1
Domain Architecture
Description	T-complex protein 1 subunit alpha A (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1A) (TCP-1-A).

TCPA2_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.158144 (rank : 78)
Query Neighborhood Hits	217	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	P11983	Gene names	Cct1, Ccta, Tcp1
Domain Architecture
Description	T-complex protein 1 subunit alpha B (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1B) (TCP-1-B).

TCPA_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.159130 (rank : 76)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	P17987, Q15556, Q5TCM3	Gene names	CCT1, CCTA, TCP1
Domain Architecture
Description	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha).

TCPD_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.168376 (rank : 74)
Query Neighborhood Hits	217	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	P50991, O14870, Q96C51	Gene names	CCT4, CCTD, SRB
Domain Architecture
Description	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding).

TCPD_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.166402 (rank : 75)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	11
SwissProt Accessions	P80315	Gene names	Cct4, Cctd
Domain Architecture
Description	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (A45).

TCPQ_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.156633 (rank : 80)
Query Neighborhood Hits	217	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P50990	Gene names	CCT8, CCTQ, KIAA0002
Domain Architecture
Description	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (NY-REN-15 antigen).

TCPQ_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.156243 (rank : 81)
Query Neighborhood Hits	217	Target Neighborhood Hits	33	Shared Neighborhood Hits	10
SwissProt Accessions	P42932	Gene names	Cct8, Cctq
Domain Architecture
Description	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta).

TCPZ_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.173256 (rank : 73)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	P40227, Q75LP4, Q96S46	Gene names	CCT6A, CCT6, CCTZ
Domain Architecture
Description	T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) (Tcp20) (HTR3) (Acute morphine dependence-related protein 2).

TCPZ_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.173501 (rank : 72)
Query Neighborhood Hits	217	Target Neighborhood Hits	40	Shared Neighborhood Hits	10
SwissProt Accessions	P80317	Gene names	Cct6a, Cct6, Cctz, Cctz1
Domain Architecture
Description	T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1).

TSC1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.053501 (rank : 157)
Query Neighborhood Hits	217	Target Neighborhood Hits	765	Shared Neighborhood Hits	44
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

Hits sorted by NC score

FYV1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	217	Target Neighborhood Hits	217	Shared Neighborhood Hits	217
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.990390 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	217	Target Neighborhood Hits	191	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY21_HUMAN
NC score	0.623906 (rank : 3)	θ value	2.60593e-15 (rank : 5)
Query Neighborhood Hits	217	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
NC score	0.615828 (rank : 4)	θ value	1.86753e-13 (rank : 6)
Query Neighborhood Hits	217	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
NC score	0.578991 (rank : 5)	θ value	4.16044e-13 (rank : 7)
Query Neighborhood Hits	217	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.516728 (rank : 6)	θ value	5.08577e-11 (rank : 13)
Query Neighborhood Hits	217	Target Neighborhood Hits	134	Shared Neighborhood Hits	60
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_MOUSE
NC score	0.511108 (rank : 7)	θ value	1.02475e-11 (rank : 9)
Query Neighborhood Hits	217	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY16_HUMAN
NC score	0.509479 (rank : 8)	θ value	2.69671e-12 (rank : 8)
Query Neighborhood Hits	217	Target Neighborhood Hits	125	Shared Neighborhood Hits	55
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

PKHF2_MOUSE
NC score	0.491018 (rank : 9)	θ value	1.17247e-07 (rank : 33)
Query Neighborhood Hits	217	Target Neighborhood Hits	77	Shared Neighborhood Hits	53
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.485723 (rank : 10)	θ value	5.81887e-07 (rank : 38)
Query Neighborhood Hits	217	Target Neighborhood Hits	75	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ZFYV1_HUMAN
NC score	0.479062 (rank : 11)	θ value	3.64472e-09 (rank : 18)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.476448 (rank : 12)	θ value	6.21693e-09 (rank : 19)
Query Neighborhood Hits	217	Target Neighborhood Hits	153	Shared Neighborhood Hits	56
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

PKHF1_MOUSE
NC score	0.470146 (rank : 13)	θ value	8.40245e-06 (rank : 52)
Query Neighborhood Hits	217	Target Neighborhood Hits	80	Shared Neighborhood Hits	53
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
NC score	0.467032 (rank : 14)	θ value	7.1131e-05 (rank : 58)
Query Neighborhood Hits	217	Target Neighborhood Hits	76	Shared Neighborhood Hits	55
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

RBNS5_HUMAN
NC score	0.405111 (rank : 15)	θ value	1.29631e-06 (rank : 42)
Query Neighborhood Hits	217	Target Neighborhood Hits	242	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.401430 (rank : 16)	θ value	1.29631e-06 (rank : 43)
Query Neighborhood Hits	217	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

HGS_MOUSE
NC score	0.398473 (rank : 17)	θ value	4.45536e-07 (rank : 37)
Query Neighborhood Hits	217	Target Neighborhood Hits	589	Shared Neighborhood Hits	76
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.398031 (rank : 18)	θ value	9.92553e-07 (rank : 40)
Query Neighborhood Hits	217	Target Neighborhood Hits	517	Shared Neighborhood Hits	69
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ZFY19_HUMAN
NC score	0.378187 (rank : 19)	θ value	0.00020696 (rank : 63)
Query Neighborhood Hits	217	Target Neighborhood Hits	206	Shared Neighborhood Hits	56
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

FGD6_HUMAN
NC score	0.374256 (rank : 20)	θ value	8.97725e-08 (rank : 29)
Query Neighborhood Hits	217	Target Neighborhood Hits	237	Shared Neighborhood Hits	61
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ZFY19_MOUSE
NC score	0.372012 (rank : 21)	θ value	0.00298849 (rank : 71)
Query Neighborhood Hits	217	Target Neighborhood Hits	143	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY27_HUMAN
NC score	0.372000 (rank : 22)	θ value	1.87187e-05 (rank : 54)
Query Neighborhood Hits	217	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FGD6_MOUSE
NC score	0.368536 (rank : 23)	θ value	1.06045e-08 (rank : 20)
Query Neighborhood Hits	217	Target Neighborhood Hits	282	Shared Neighborhood Hits	60
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ZFY27_MOUSE
NC score	0.367201 (rank : 24)	θ value	4.1701e-05 (rank : 57)
Query Neighborhood Hits	217	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

PI52A_HUMAN
NC score	0.353709 (rank : 25)	θ value	2.52405e-10 (rank : 15)
Query Neighborhood Hits	217	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P48426, P53807, Q5VUX3	Gene names	PIP5K2A, PIP5K2
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha) (PtdIns(4)P-5-kinase B isoform) (PIP5KIII) (PtdIns(4)P-5-kinase C isoform).

PI52A_MOUSE
NC score	0.353079 (rank : 26)	θ value	3.29651e-10 (rank : 16)
Query Neighborhood Hits	217	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	O70172	Gene names	Pip5k2a
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha).

FGD5_MOUSE
NC score	0.347352 (rank : 27)	θ value	0.00390308 (rank : 72)
Query Neighborhood Hits	217	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD5_HUMAN
NC score	0.345711 (rank : 28)	θ value	0.00102713 (rank : 66)
Query Neighborhood Hits	217	Target Neighborhood Hits	235	Shared Neighborhood Hits	58
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

PI52B_MOUSE
NC score	0.339543 (rank : 29)	θ value	5.26297e-08 (rank : 26)
Query Neighborhood Hits	217	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XI4, Q8VHB2	Gene names	Pip5k2b
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

PI52B_HUMAN
NC score	0.339495 (rank : 30)	θ value	5.26297e-08 (rank : 25)
Query Neighborhood Hits	217	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P78356, Q5U0E8, Q8TBP2	Gene names	PIP5K2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

RUFY1_MOUSE
NC score	0.333997 (rank : 31)	θ value	3.89403e-11 (rank : 12)
Query Neighborhood Hits	217	Target Neighborhood Hits	765	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

FGD2_HUMAN
NC score	0.332409 (rank : 32)	θ value	4.92598e-06 (rank : 50)
Query Neighborhood Hits	217	Target Neighborhood Hits	151	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

MTMR3_HUMAN
NC score	0.331786 (rank : 33)	θ value	2.98157e-11 (rank : 10)
Query Neighborhood Hits	217	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY1_HUMAN
NC score	0.330594 (rank : 34)	θ value	3.89403e-11 (rank : 11)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	87
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

FGD2_MOUSE
NC score	0.325980 (rank : 35)	θ value	9.29e-05 (rank : 59)
Query Neighborhood Hits	217	Target Neighborhood Hits	163	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

PI51A_MOUSE
NC score	0.323739 (rank : 36)	θ value	2.36244e-08 (rank : 23)
Query Neighborhood Hits	217	Target Neighborhood Hits	21	Shared Neighborhood Hits	12
SwissProt Accessions	P70182, Q8K0D3, Q99L80	Gene names	Pip5k1a, Pip5k1b
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (Phosphatidylinositol-4-phosphate 5- kinase type I beta) (PI4P5KIbeta) (68 kDa type I phosphatidylinositol- 4-phosphate 5-kinase).

RUFY2_MOUSE
NC score	0.322268 (rank : 37)	θ value	5.26297e-08 (rank : 27)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PI51C_MOUSE
NC score	0.319890 (rank : 38)	θ value	2.36244e-08 (rank : 24)
Query Neighborhood Hits	217	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI51B_HUMAN
NC score	0.319226 (rank : 39)	θ value	8.97725e-08 (rank : 30)
Query Neighborhood Hits	217	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	O14986, P78518, P78519, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749	Gene names	PIP5K1B, STM7
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Type I phosphatidylinositol-4-phosphate 5- kinase beta) (Protein STM-7).

TCPG_MOUSE
NC score	0.319078 (rank : 40)	θ value	1.09232e-21 (rank : 3)
Query Neighborhood Hits	217	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	P80318	Gene names	Cct3, Cctg
Domain Architecture
Description	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Matricin) (mTRiC-P5).

PI51B_MOUSE
NC score	0.317616 (rank : 41)	θ value	1.53129e-07 (rank : 34)
Query Neighborhood Hits	217	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	P70181, O70335, Q8JZY6	Gene names	Pip5k1b, Pip5k1a
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PIP5KIalpha).

TCPG_HUMAN
NC score	0.316107 (rank : 42)	θ value	1.2077e-20 (rank : 4)
Query Neighborhood Hits	217	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	P49368, Q5SZY1, Q9BR64	Gene names	CCT3, CCTG, TRIC5
Domain Architecture
Description	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5).

FGD4_HUMAN
NC score	0.314851 (rank : 43)	θ value	1.09739e-05 (rank : 53)
Query Neighborhood Hits	217	Target Neighborhood Hits	219	Shared Neighborhood Hits	56
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

PI51C_HUMAN
NC score	0.314778 (rank : 44)	θ value	6.87365e-08 (rank : 28)
Query Neighborhood Hits	217	Target Neighborhood Hits	109	Shared Neighborhood Hits	17
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

FGD4_MOUSE
NC score	0.313408 (rank : 45)	θ value	8.40245e-06 (rank : 51)
Query Neighborhood Hits	217	Target Neighborhood Hits	227	Shared Neighborhood Hits	55
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

PI51A_HUMAN
NC score	0.312593 (rank : 46)	θ value	9.92553e-07 (rank : 41)
Query Neighborhood Hits	217	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

WDFY3_MOUSE
NC score	0.299497 (rank : 47)	θ value	8.97725e-08 (rank : 32)
Query Neighborhood Hits	217	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.298552 (rank : 48)	θ value	8.97725e-08 (rank : 31)
Query Neighborhood Hits	217	Target Neighborhood Hits	348	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

FGD3_HUMAN
NC score	0.289472 (rank : 49)	θ value	0.000121331 (rank : 60)
Query Neighborhood Hits	217	Target Neighborhood Hits	249	Shared Neighborhood Hits	59
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD1_MOUSE
NC score	0.287577 (rank : 50)	θ value	0.0148317 (rank : 78)
Query Neighborhood Hits	217	Target Neighborhood Hits	387	Shared Neighborhood Hits	61
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.287545 (rank : 51)	θ value	0.0148317 (rank : 77)
Query Neighborhood Hits	217	Target Neighborhood Hits	367	Shared Neighborhood Hits	57
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

WDFY1_HUMAN
NC score	0.282828 (rank : 52)	θ value	0.000461057 (rank : 64)
Query Neighborhood Hits	217	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_MOUSE
NC score	0.276785 (rank : 53)	θ value	0.000786445 (rank : 65)
Query Neighborhood Hits	217	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.273663 (rank : 54)	θ value	0.00102713 (rank : 67)
Query Neighborhood Hits	217	Target Neighborhood Hits	332	Shared Neighborhood Hits	49
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

RUFY2_HUMAN
NC score	0.259456 (rank : 55)	θ value	1.80886e-08 (rank : 22)
Query Neighborhood Hits	217	Target Neighborhood Hits	1208	Shared Neighborhood Hits	97
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

FGD3_MOUSE
NC score	0.249719 (rank : 56)	θ value	0.0431538 (rank : 83)
Query Neighborhood Hits	217	Target Neighborhood Hits	257	Shared Neighborhood Hits	56
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

TCPW_MOUSE
NC score	0.249590 (rank : 57)	θ value	1.38499e-08 (rank : 21)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q61390, Q9R1U2	Gene names	Cct6b
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (Cctz- 2).

FYCO1_HUMAN
NC score	0.245232 (rank : 58)	θ value	1.47974e-10 (rank : 14)
Query Neighborhood Hits	217	Target Neighborhood Hits	1149	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

TCPW_HUMAN
NC score	0.241597 (rank : 59)	θ value	1.53129e-07 (rank : 35)
Query Neighborhood Hits	217	Target Neighborhood Hits	29	Shared Neighborhood Hits	13
SwissProt Accessions	Q92526, Q8TC34	Gene names	CCT6B
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (TCP-1- zeta-like) (CCT-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303).

TCPE_MOUSE
NC score	0.239595 (rank : 60)	θ value	2.21117e-06 (rank : 44)
Query Neighborhood Hits	217	Target Neighborhood Hits	37	Shared Neighborhood Hits	13
SwissProt Accessions	P80316	Gene names	Cct5, Ccte
Domain Architecture
Description	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon).

TCPH_HUMAN
NC score	0.239408 (rank : 61)	θ value	2.21117e-06 (rank : 45)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q99832, O14871	Gene names	CCT7, CCTH, NIP7-1
Domain Architecture
Description	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef- interacting protein).

TCPH_MOUSE
NC score	0.238607 (rank : 62)	θ value	2.88788e-06 (rank : 46)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	P80313	Gene names	Cct7, Ccth
Domain Architecture
Description	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta).

TCPE_HUMAN
NC score	0.238449 (rank : 63)	θ value	3.77169e-06 (rank : 48)
Query Neighborhood Hits	217	Target Neighborhood Hits	39	Shared Neighborhood Hits	13
SwissProt Accessions	P48643	Gene names	CCT5, CCTE, KIAA0098
Domain Architecture
Description	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon).

FYCO1_MOUSE
NC score	0.231168 (rank : 64)	θ value	3.64472e-09 (rank : 17)
Query Neighborhood Hits	217	Target Neighborhood Hits	1059	Shared Neighborhood Hits	90
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

TCPB_HUMAN
NC score	0.210384 (rank : 65)	θ value	0.00228821 (rank : 68)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P78371, Q6IAT3	Gene names	CCT2, 99D8.1, CCTB
Domain Architecture
Description	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta).

TCPB_MOUSE
NC score	0.209479 (rank : 66)	θ value	0.00298849 (rank : 69)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P80314, Q9R1U0	Gene names	Cct2, Cctb
Domain Architecture
Description	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta).

ANFY1_MOUSE
NC score	0.205671 (rank : 67)	θ value	4.45536e-07 (rank : 36)
Query Neighborhood Hits	217	Target Neighborhood Hits	480	Shared Neighborhood Hits	54
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.203649 (rank : 68)	θ value	9.92553e-07 (rank : 39)
Query Neighborhood Hits	217	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

GP155_HUMAN
NC score	0.194045 (rank : 69)	θ value	0.000121331 (rank : 61)
Query Neighborhood Hits	217	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

EEA1_MOUSE
NC score	0.192289 (rank : 70)	θ value	3.77169e-06 (rank : 47)
Query Neighborhood Hits	217	Target Neighborhood Hits	1637	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EEA1_HUMAN
NC score	0.178721 (rank : 71)	θ value	4.92598e-06 (rank : 49)
Query Neighborhood Hits	217	Target Neighborhood Hits	1796	Shared Neighborhood Hits	103
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

TCPZ_MOUSE
NC score	0.173501 (rank : 72)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	217	Target Neighborhood Hits	40	Shared Neighborhood Hits	10
SwissProt Accessions	P80317	Gene names	Cct6a, Cct6, Cctz, Cctz1
Domain Architecture
Description	T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1).

TCPZ_HUMAN
NC score	0.173256 (rank : 73)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	P40227, Q75LP4, Q96S46	Gene names	CCT6A, CCT6, CCTZ
Domain Architecture
Description	T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) (Tcp20) (HTR3) (Acute morphine dependence-related protein 2).

TCPD_HUMAN
NC score	0.168376 (rank : 74)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	217	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	P50991, O14870, Q96C51	Gene names	CCT4, CCTD, SRB
Domain Architecture
Description	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding).

TCPD_MOUSE
NC score	0.166402 (rank : 75)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	11
SwissProt Accessions	P80315	Gene names	Cct4, Cctd
Domain Architecture
Description	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (A45).

TCPA_HUMAN
NC score	0.159130 (rank : 76)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	P17987, Q15556, Q5TCM3	Gene names	CCT1, CCTA, TCP1
Domain Architecture
Description	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha).

TCPA1_MOUSE
NC score	0.158155 (rank : 77)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P11984	Gene names	Cct1, Ccta, Tcp1
Domain Architecture
Description	T-complex protein 1 subunit alpha A (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1A) (TCP-1-A).

TCPA2_MOUSE
NC score	0.158144 (rank : 78)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	217	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	P11983	Gene names	Cct1, Ccta, Tcp1
Domain Architecture
Description	T-complex protein 1 subunit alpha B (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1B) (TCP-1-B).

PREX1_HUMAN
NC score	0.157883 (rank : 79)	θ value	0.000121331 (rank : 62)
Query Neighborhood Hits	217	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TCPQ_HUMAN
NC score	0.156633 (rank : 80)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	217	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P50990	Gene names	CCT8, CCTQ, KIAA0002
Domain Architecture
Description	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (NY-REN-15 antigen).

TCPQ_MOUSE
NC score	0.156243 (rank : 81)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	217	Target Neighborhood Hits	33	Shared Neighborhood Hits	10
SwissProt Accessions	P42932	Gene names	Cct8, Cctq
Domain Architecture
Description	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta).

RUFY3_MOUSE
NC score	0.120188 (rank : 82)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	217	Target Neighborhood Hits	579	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RPGF4_MOUSE
NC score	0.119593 (rank : 83)	θ value	3.19293e-05 (rank : 56)
Query Neighborhood Hits	217	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
NC score	0.119263 (rank : 84)	θ value	3.19293e-05 (rank : 55)
Query Neighborhood Hits	217	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RUFY3_HUMAN
NC score	0.118590 (rank : 85)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	217	Target Neighborhood Hits	594	Shared Neighborhood Hits	32
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RNF34_MOUSE
NC score	0.116589 (rank : 86)	θ value	0.813845 (rank : 109)
Query Neighborhood Hits	217	Target Neighborhood Hits	160	Shared Neighborhood Hits	34
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

CH60_MOUSE
NC score	0.111957 (rank : 87)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	P63038, P19226, P19227, P97602	Gene names	Hspd1, Hsp60
Domain Architecture	No domain graphic available
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (HSP-65).

RNF34_HUMAN
NC score	0.105527 (rank : 88)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	217	Target Neighborhood Hits	153	Shared Neighborhood Hits	31
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

CH60_HUMAN
NC score	0.104492 (rank : 89)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	217	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P10809	Gene names	HSPD1, HSP60
Domain Architecture
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60).

MKKS_MOUSE
NC score	0.096214 (rank : 90)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	217	Target Neighborhood Hits	25	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JI70	Gene names	Mkks
Domain Architecture
Description	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.

CASP_HUMAN
NC score	0.090247 (rank : 91)	θ value	0.00869519 (rank : 74)
Query Neighborhood Hits	217	Target Neighborhood Hits	1131	Shared Neighborhood Hits	59
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CASP_MOUSE
NC score	0.087297 (rank : 92)	θ value	0.0252991 (rank : 81)
Query Neighborhood Hits	217	Target Neighborhood Hits	1152	Shared Neighborhood Hits	62
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_MOUSE
NC score	0.086558 (rank : 93)	θ value	0.0113563 (rank : 76)
Query Neighborhood Hits	217	Target Neighborhood Hits	1620	Shared Neighborhood Hits	66
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CRF_MOUSE
NC score	0.086528 (rank : 94)	θ value	0.00665767 (rank : 73)
Query Neighborhood Hits	217	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CIT0	Gene names	Crh
Domain Architecture	No domain graphic available
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

CUTL1_HUMAN
NC score	0.085328 (rank : 95)	θ value	0.00869519 (rank : 75)
Query Neighborhood Hits	217	Target Neighborhood Hits	1574	Shared Neighborhood Hits	63
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

DEPD5_MOUSE
NC score	0.085207 (rank : 96)	θ value	0.0961366 (rank : 86)
Query Neighborhood Hits	217	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

FARP2_HUMAN
NC score	0.085097 (rank : 97)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	217	Target Neighborhood Hits	240	Shared Neighborhood Hits	23
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

HAPIP_HUMAN
NC score	0.084771 (rank : 98)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	217	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

DEPD5_HUMAN
NC score	0.084026 (rank : 99)	θ value	0.163984 (rank : 92)
Query Neighborhood Hits	217	Target Neighborhood Hits	40	Shared Neighborhood Hits	14
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

RFFL_MOUSE
NC score	0.083937 (rank : 100)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	217	Target Neighborhood Hits	145	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

FARP2_MOUSE
NC score	0.083850 (rank : 101)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	217	Target Neighborhood Hits	209	Shared Neighborhood Hits	18
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

RPGF5_MOUSE
NC score	0.083362 (rank : 102)	θ value	0.21417 (rank : 96)
Query Neighborhood Hits	217	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

FARP1_HUMAN
NC score	0.083016 (rank : 103)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	217	Target Neighborhood Hits	241	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

RFFL_HUMAN
NC score	0.081980 (rank : 104)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	217	Target Neighborhood Hits	175	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

ECT2_MOUSE
NC score	0.079842 (rank : 105)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	217	Target Neighborhood Hits	98	Shared Neighborhood Hits	15
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

MKKS_HUMAN
NC score	0.078580 (rank : 106)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	217	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NPJ1	Gene names	MKKS
Domain Architecture
Description	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Bardet- Biedl syndrome 6 protein).

ECT2_HUMAN
NC score	0.077955 (rank : 107)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	217	Target Neighborhood Hits	98	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RGS7_MOUSE
NC score	0.074941 (rank : 108)	θ value	0.0148317 (rank : 80)
Query Neighborhood Hits	217	Target Neighborhood Hits	79	Shared Neighborhood Hits	12
SwissProt Accessions	O54829	Gene names	Rgs7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

RGS7_HUMAN
NC score	0.074659 (rank : 109)	θ value	0.0148317 (rank : 79)
Query Neighborhood Hits	217	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

PKHG1_HUMAN
NC score	0.072713 (rank : 110)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	217	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

GNRP_HUMAN
NC score	0.070219 (rank : 111)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	217	Target Neighborhood Hits	239	Shared Neighborhood Hits	31
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

BBS10_HUMAN
NC score	0.070132 (rank : 112)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TAM1, Q96CW2, Q9H5D2	Gene names	BBS10, C12orf58
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein.

RGS6_HUMAN
NC score	0.069081 (rank : 113)	θ value	0.125558 (rank : 89)
Query Neighborhood Hits	217	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

CJ064_HUMAN
NC score	0.068730 (rank : 114)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	217	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

GNRP_MOUSE
NC score	0.068393 (rank : 115)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	217	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG5_HUMAN
NC score	0.068102 (rank : 116)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	217	Target Neighborhood Hits	172	Shared Neighborhood Hits	17
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGA_MOUSE
NC score	0.067737 (rank : 117)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	217	Target Neighborhood Hits	125	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MCF2L_MOUSE
NC score	0.067415 (rank : 118)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	217	Target Neighborhood Hits	255	Shared Neighborhood Hits	32
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

RGS6_MOUSE
NC score	0.066968 (rank : 119)	θ value	0.125558 (rank : 90)
Query Neighborhood Hits	217	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

ARHGA_HUMAN
NC score	0.066673 (rank : 120)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	217	Target Neighborhood Hits	187	Shared Neighborhood Hits	18
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

GCC2_MOUSE
NC score	0.064778 (rank : 121)	θ value	0.0252991 (rank : 82)
Query Neighborhood Hits	217	Target Neighborhood Hits	1619	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

ZMYM3_MOUSE
NC score	0.064188 (rank : 122)	θ value	0.0961366 (rank : 88)
Query Neighborhood Hits	217	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

ZMYM3_HUMAN
NC score	0.064100 (rank : 123)	θ value	0.0961366 (rank : 87)
Query Neighborhood Hits	217	Target Neighborhood Hits	223	Shared Neighborhood Hits	12
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

MCF2_HUMAN
NC score	0.063939 (rank : 124)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	26
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

SWP70_HUMAN
NC score	0.063682 (rank : 125)	θ value	8.99809 (rank : 213)
Query Neighborhood Hits	217	Target Neighborhood Hits	973	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

NGEF_HUMAN
NC score	0.062409 (rank : 126)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHG4_HUMAN
NC score	0.062342 (rank : 127)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	217	Target Neighborhood Hits	200	Shared Neighborhood Hits	18
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

NGEF_MOUSE
NC score	0.061486 (rank : 128)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	217	Target Neighborhood Hits	228	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG4_HUMAN
NC score	0.061424 (rank : 129)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	217	Target Neighborhood Hits	242	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BCR_HUMAN
NC score	0.060426 (rank : 130)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	217	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

INVO_HUMAN
NC score	0.060384 (rank : 131)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	217	Target Neighborhood Hits	636	Shared Neighborhood Hits	43
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

ITSN1_HUMAN
NC score	0.060311 (rank : 132)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	217	Target Neighborhood Hits	1757	Shared Neighborhood Hits	69
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHGF_HUMAN
NC score	0.060220 (rank : 133)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	217	Target Neighborhood Hits	214	Shared Neighborhood Hits	16
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

SWP70_MOUSE
NC score	0.060201 (rank : 134)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	217	Target Neighborhood Hits	1097	Shared Neighborhood Hits	64
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ITSN1_MOUSE
NC score	0.060137 (rank : 135)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	217	Target Neighborhood Hits	1669	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHGG_HUMAN
NC score	0.059950 (rank : 136)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	217	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG4_MOUSE
NC score	0.059907 (rank : 137)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	217	Target Neighborhood Hits	185	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ITSN2_MOUSE
NC score	0.059281 (rank : 138)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	217	Target Neighborhood Hits	1371	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ABR_HUMAN
NC score	0.058942 (rank : 139)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BBS10_MOUSE
NC score	0.058305 (rank : 140)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	217	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBI2	Gene names	Bbs10
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein homolog.

ITSN2_HUMAN
NC score	0.057890 (rank : 141)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	217	Target Neighborhood Hits	1173	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

GOGA5_MOUSE
NC score	0.057661 (rank : 142)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	217	Target Neighborhood Hits	1434	Shared Neighborhood Hits	67
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

ARHG9_HUMAN
NC score	0.057466 (rank : 143)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	217	Target Neighborhood Hits	235	Shared Neighborhood Hits	22
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

DVL3_HUMAN
NC score	0.057375 (rank : 144)	θ value	0.21417 (rank : 94)
Query Neighborhood Hits	217	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

CUTL2_MOUSE
NC score	0.057278 (rank : 145)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	217	Target Neighborhood Hits	771	Shared Neighborhood Hits	35
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

FNBP2_HUMAN
NC score	0.057199 (rank : 146)	θ value	0.0431538 (rank : 84)
Query Neighborhood Hits	217	Target Neighborhood Hits	432	Shared Neighborhood Hits	26
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CCDC6_HUMAN
NC score	0.057130 (rank : 147)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	217	Target Neighborhood Hits	723	Shared Neighborhood Hits	44
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

ARHG9_MOUSE
NC score	0.056873 (rank : 148)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	217	Target Neighborhood Hits	234	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

RABE2_MOUSE
NC score	0.056464 (rank : 149)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	217	Target Neighborhood Hits	598	Shared Neighborhood Hits	38
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

GOGA5_HUMAN
NC score	0.056368 (rank : 150)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	217	Target Neighborhood Hits	1168	Shared Neighborhood Hits	55
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

ARHG2_MOUSE
NC score	0.056163 (rank : 151)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	217	Target Neighborhood Hits	120	Shared Neighborhood Hits	15
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

GOGA3_MOUSE
NC score	0.056151 (rank : 152)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	217	Target Neighborhood Hits	1437	Shared Neighborhood Hits	67
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

DVL3_MOUSE
NC score	0.055836 (rank : 153)	θ value	0.21417 (rank : 95)
Query Neighborhood Hits	217	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

ARHGG_MOUSE
NC score	0.055774 (rank : 154)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	217	Target Neighborhood Hits	152	Shared Neighborhood Hits	17
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

GOGA1_HUMAN
NC score	0.054601 (rank : 155)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	217	Target Neighborhood Hits	1222	Shared Neighborhood Hits	62
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

CUTL2_HUMAN
NC score	0.053846 (rank : 156)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	217	Target Neighborhood Hits	906	Shared Neighborhood Hits	44
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

TSC1_HUMAN
NC score	0.053501 (rank : 157)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	217	Target Neighborhood Hits	765	Shared Neighborhood Hits	44
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

GOGA2_HUMAN
NC score	0.053333 (rank : 158)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	217	Target Neighborhood Hits	856	Shared Neighborhood Hits	51
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

CE290_HUMAN
NC score	0.053155 (rank : 159)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	217	Target Neighborhood Hits	1553	Shared Neighborhood Hits	59
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

RABE2_HUMAN
NC score	0.053115 (rank : 160)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	217	Target Neighborhood Hits	545	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

CEP63_HUMAN
NC score	0.052858 (rank : 161)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	217	Target Neighborhood Hits	1005	Shared Neighborhood Hits	57
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CCHCR_MOUSE
NC score	0.052756 (rank : 162)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	217	Target Neighborhood Hits	932	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

RABE1_HUMAN
NC score	0.052719 (rank : 163)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	217	Target Neighborhood Hits	1104	Shared Neighborhood Hits	55
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

GOGA3_HUMAN
NC score	0.052621 (rank : 164)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	217	Target Neighborhood Hits	1317	Shared Neighborhood Hits	59
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA1_MOUSE
NC score	0.052263 (rank : 165)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	217	Target Neighborhood Hits	994	Shared Neighborhood Hits	52
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

MD1L1_MOUSE
NC score	0.052208 (rank : 166)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	217	Target Neighborhood Hits	1001	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

CF182_MOUSE
NC score	0.051961 (rank : 167)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	217	Target Neighborhood Hits	551	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

GOGA2_MOUSE
NC score	0.051945 (rank : 168)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	46
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

CNTRB_MOUSE
NC score	0.051746 (rank : 169)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	217	Target Neighborhood Hits	1029	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CCD21_HUMAN
NC score	0.051636 (rank : 170)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	217	Target Neighborhood Hits	1228	Shared Neighborhood Hits	59
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CP135_HUMAN
NC score	0.051624 (rank : 171)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	217	Target Neighborhood Hits	1290	Shared Neighborhood Hits	55
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

KNTC2_HUMAN
NC score	0.051465 (rank : 172)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	217	Target Neighborhood Hits	673	Shared Neighborhood Hits	41
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

KTN1_MOUSE
NC score	0.051417 (rank : 173)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	217	Target Neighborhood Hits	1324	Shared Neighborhood Hits	57
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

RBP24_HUMAN
NC score	0.051384 (rank : 174)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	217	Target Neighborhood Hits	1559	Shared Neighborhood Hits	64
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.051364 (rank : 175)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	217	Target Neighborhood Hits	1558	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

SRGP1_HUMAN
NC score	0.051043 (rank : 176)	θ value	0.0431538 (rank : 85)
Query Neighborhood Hits	217	Target Neighborhood Hits	390	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

LBC_HUMAN
NC score	0.050795 (rank : 177)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	217	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG1_HUMAN
NC score	0.050518 (rank : 178)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	217	Target Neighborhood Hits	176	Shared Neighborhood Hits	18
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

CARD9_HUMAN
NC score	0.050324 (rank : 179)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	217	Target Neighborhood Hits	602	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

ARHG1_MOUSE
NC score	0.050323 (rank : 180)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	217	Target Neighborhood Hits	266	Shared Neighborhood Hits	21
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

RB6I2_MOUSE
NC score	0.050273 (rank : 181)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	217	Target Neighborhood Hits	1433	Shared Neighborhood Hits	55
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

CP250_HUMAN
NC score	0.050019 (rank : 182)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	217	Target Neighborhood Hits	1805	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

DMD_MOUSE
NC score	0.049917 (rank : 183)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	217	Target Neighborhood Hits	1111	Shared Neighborhood Hits	57
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

SPTN5_HUMAN
NC score	0.049656 (rank : 184)	θ value	0.365318 (rank : 101)
Query Neighborhood Hits	217	Target Neighborhood Hits	674	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

TGON2_HUMAN
NC score	0.049563 (rank : 185)	θ value	0.00298849 (rank : 70)
Query Neighborhood Hits	217	Target Neighborhood Hits	1037	Shared Neighborhood Hits	40
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CP250_MOUSE
NC score	0.049172 (rank : 186)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	217	Target Neighborhood Hits	1583	Shared Neighborhood Hits	63
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

MY18A_HUMAN
NC score	0.049008 (rank : 187)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	217	Target Neighborhood Hits	1929	Shared Neighborhood Hits	88
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
NC score	0.048280 (rank : 188)	θ value	6.88961 (rank : 184)
Query Neighborhood Hits	217	Target Neighborhood Hits	1989	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CTDP1_HUMAN
NC score	0.047567 (rank : 189)	θ value	0.62314 (rank : 104)
Query Neighborhood Hits	217	Target Neighborhood Hits	416	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

SPTA1_HUMAN
NC score	0.047135 (rank : 190)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	217	Target Neighborhood Hits	748	Shared Neighborhood Hits	47
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SYNE1_HUMAN
NC score	0.046296 (rank : 191)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	217	Target Neighborhood Hits	1484	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

MYH10_HUMAN
NC score	0.046166 (rank : 192)	θ value	0.163984 (rank : 93)
Query Neighborhood Hits	217	Target Neighborhood Hits	1620	Shared Neighborhood Hits	68
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
NC score	0.045513 (rank : 193)	θ value	0.365318 (rank : 99)
Query Neighborhood Hits	217	Target Neighborhood Hits	1612	Shared Neighborhood Hits	67
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

APOA4_MOUSE
NC score	0.045183 (rank : 194)	θ value	1.06291 (rank : 111)
Query Neighborhood Hits	217	Target Neighborhood Hits	435	Shared Neighborhood Hits	27
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

DSPP_HUMAN
NC score	0.044762 (rank : 195)	θ value	0.62314 (rank : 105)
Query Neighborhood Hits	217	Target Neighborhood Hits	645	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DSPP_MOUSE
NC score	0.044667 (rank : 196)	θ value	0.813845 (rank : 107)
Query Neighborhood Hits	217	Target Neighborhood Hits	491	Shared Neighborhood Hits	29
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

HOOK2_MOUSE
NC score	0.044505 (rank : 197)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	217	Target Neighborhood Hits	736	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

MYH11_HUMAN
NC score	0.043827 (rank : 198)	θ value	1.81305 (rank : 118)
Query Neighborhood Hits	217	Target Neighborhood Hits	1806	Shared Neighborhood Hits	65
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
NC score	0.043143 (rank : 199)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	217	Target Neighborhood Hits	1777	Shared Neighborhood Hits	67
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NEMO_MOUSE
NC score	0.041972 (rank : 200)	θ value	8.99809 (rank : 205)
Query Neighborhood Hits	217	Target Neighborhood Hits	658	Shared Neighborhood Hits	35
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

SPTB2_HUMAN
NC score	0.040229 (rank : 201)	θ value	4.03905 (rank : 159)
Query Neighborhood Hits	217	Target Neighborhood Hits	748	Shared Neighborhood Hits	43
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.040028 (rank : 202)	θ value	8.99809 (rank : 210)
Query Neighborhood Hits	217	Target Neighborhood Hits	770	Shared Neighborhood Hits	46
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ZCH10_HUMAN
NC score	0.039784 (rank : 203)	θ value	1.38821 (rank : 113)
Query Neighborhood Hits	217	Target Neighborhood Hits	123	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

DVL2_MOUSE
NC score	0.035633 (rank : 204)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	217	Target Neighborhood Hits	233	Shared Neighborhood Hits	20
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
NC score	0.034946 (rank : 205)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	217	Target Neighborhood Hits	223	Shared Neighborhood Hits	19
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

SNX23_HUMAN
NC score	0.034789 (rank : 206)	θ value	0.813845 (rank : 110)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	52
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

TRIO_HUMAN
NC score	0.032459 (rank : 207)	θ value	1.06291 (rank : 112)
Query Neighborhood Hits	217	Target Neighborhood Hits	1580	Shared Neighborhood Hits	56
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

MYRIP_HUMAN
NC score	0.031460 (rank : 208)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	217	Target Neighborhood Hits	269	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

SRGP2_MOUSE
NC score	0.031211 (rank : 209)	θ value	8.99809 (rank : 212)
Query Neighborhood Hits	217	Target Neighborhood Hits	324	Shared Neighborhood Hits	23
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ARP5_MOUSE
NC score	0.031077 (rank : 210)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	217	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	Q80US4, Q8BL26	Gene names	Actr5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5.

AKAP2_HUMAN
NC score	0.030872 (rank : 211)	θ value	4.03905 (rank : 148)
Query Neighborhood Hits	217	Target Neighborhood Hits	507	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

SRGP2_HUMAN
NC score	0.030735 (rank : 212)	θ value	8.99809 (rank : 211)
Query Neighborhood Hits	217	Target Neighborhood Hits	331	Shared Neighborhood Hits	21
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

DMP1_HUMAN
NC score	0.030525 (rank : 213)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	217	Target Neighborhood Hits	491	Shared Neighborhood Hits	26
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

DVL1_MOUSE
NC score	0.030214 (rank : 214)	θ value	8.99809 (rank : 202)
Query Neighborhood Hits	217	Target Neighborhood Hits	146	Shared Neighborhood Hits	16
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1L_HUMAN
NC score	0.029779 (rank : 215)	θ value	8.99809 (rank : 201)
Query Neighborhood Hits	217	Target Neighborhood Hits	146	Shared Neighborhood Hits	17
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

SH3G2_HUMAN
NC score	0.029694 (rank : 216)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	217	Target Neighborhood Hits	324	Shared Neighborhood Hits	23
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

BPTF_HUMAN
NC score	0.029506 (rank : 217)	θ value	0.813845 (rank : 106)
Query Neighborhood Hits	217	Target Neighborhood Hits	786	Shared Neighborhood Hits	35
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

BAZ2B_HUMAN
NC score	0.027903 (rank : 218)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	217	Target Neighborhood Hits	803	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

SH3G2_MOUSE
NC score	0.027734 (rank : 219)	θ value	1.81305 (rank : 120)
Query Neighborhood Hits	217	Target Neighborhood Hits	319	Shared Neighborhood Hits	22
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ARP5_HUMAN
NC score	0.027550 (rank : 220)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	217	Target Neighborhood Hits	107	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H9F9, Q86WF7, Q8IUY5, Q8N724, Q9BRN0, Q9BVB7	Gene names	ACTR5, ARP5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16).

SOX6_MOUSE
NC score	0.027266 (rank : 221)	θ value	1.81305 (rank : 122)
Query Neighborhood Hits	217	Target Neighborhood Hits	341	Shared Neighborhood Hits	23
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

SOX6_HUMAN
NC score	0.027042 (rank : 222)	θ value	1.81305 (rank : 121)
Query Neighborhood Hits	217	Target Neighborhood Hits	332	Shared Neighborhood Hits	21
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

UB7I4_MOUSE
NC score	0.026320 (rank : 223)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	217	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

SAP_HUMAN
NC score	0.025706 (rank : 224)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	217	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	P07602, P07292, P15793, P78538, P78541, P78546, P78547, P78558, Q6IBQ6, Q92739, Q92740, Q92741, Q92742	Gene names	PSAP
Domain Architecture
Description	Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)].

NOC2L_HUMAN
NC score	0.025699 (rank : 225)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	217	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3T9, Q5SVA3, Q9BTN6	Gene names	NOC2L
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

LRC50_MOUSE
NC score	0.025551 (rank : 226)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	217	Target Neighborhood Hits	190	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D2H9, Q9CVS9	Gene names	Lrrc50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

ANR11_HUMAN
NC score	0.024451 (rank : 227)	θ value	0.47712 (rank : 102)
Query Neighborhood Hits	217	Target Neighborhood Hits	1289	Shared Neighborhood Hits	41
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

SOCS5_MOUSE
NC score	0.024436 (rank : 228)	θ value	0.365318 (rank : 100)
Query Neighborhood Hits	217	Target Neighborhood Hits	93	Shared Neighborhood Hits	3
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

UBXD7_HUMAN
NC score	0.022983 (rank : 229)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	217	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	O94888, Q6ZP77, Q86X20, Q8N327	Gene names	UBXD7, KIAA0794
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 7.

CI037_HUMAN
NC score	0.022430 (rank : 230)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	217	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2J1, Q5T368	Gene names	C9orf37
Domain Architecture	No domain graphic available
Description	Protein C9orf37.

UB7I4_HUMAN
NC score	0.022377 (rank : 231)	θ value	4.03905 (rank : 161)
Query Neighborhood Hits	217	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

YLPM1_HUMAN
NC score	0.022240 (rank : 232)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	217	Target Neighborhood Hits	670	Shared Neighborhood Hits	26
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

K1HB_HUMAN
NC score	0.021621 (rank : 233)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	217	Target Neighborhood Hits	470	Shared Neighborhood Hits	33
SwissProt Accessions	Q14525, O76010	Gene names	KRTHA3B, HHA3-II, HKA3B
Domain Architecture
Description	Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II).

MBB1A_MOUSE
NC score	0.021193 (rank : 234)	θ value	6.88961 (rank : 182)
Query Neighborhood Hits	217	Target Neighborhood Hits	233	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

ATX2L_HUMAN
NC score	0.021005 (rank : 235)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	217	Target Neighborhood Hits	443	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

PELP1_MOUSE
NC score	0.020682 (rank : 236)	θ value	6.88961 (rank : 188)
Query Neighborhood Hits	217	Target Neighborhood Hits	709	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

LAMB1_HUMAN
NC score	0.019944 (rank : 237)	θ value	8.99809 (rank : 203)
Query Neighborhood Hits	217	Target Neighborhood Hits	1018	Shared Neighborhood Hits	41
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

CDC37_MOUSE
NC score	0.019564 (rank : 238)	θ value	8.99809 (rank : 200)
Query Neighborhood Hits	217	Target Neighborhood Hits	359	Shared Neighborhood Hits	21
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

SL9A3_HUMAN
NC score	0.019131 (rank : 239)	θ value	3.0926 (rank : 143)
Query Neighborhood Hits	217	Target Neighborhood Hits	63	Shared Neighborhood Hits	7
SwissProt Accessions	P48764	Gene names	SLC9A3, NHE3
Domain Architecture
Description	Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3).

PCLO_HUMAN
NC score	0.019024 (rank : 240)	θ value	3.0926 (rank : 142)
Query Neighborhood Hits	217	Target Neighborhood Hits	2046	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

TRI32_HUMAN
NC score	0.018836 (rank : 241)	θ value	5.27518 (rank : 173)
Query Neighborhood Hits	217	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

UN84B_HUMAN
NC score	0.018751 (rank : 242)	θ value	6.88961 (rank : 197)
Query Neighborhood Hits	217	Target Neighborhood Hits	172	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UH99, O75156, Q6B4H1, Q7Z3E3	Gene names	UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2
Domain Architecture	No domain graphic available
Description	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP).

TRI32_MOUSE
NC score	0.018512 (rank : 243)	θ value	5.27518 (rank : 174)
Query Neighborhood Hits	217	Target Neighborhood Hits	271	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

AFF4_HUMAN
NC score	0.018346 (rank : 244)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	217	Target Neighborhood Hits	611	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

AFF4_MOUSE
NC score	0.017937 (rank : 245)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	217	Target Neighborhood Hits	581	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

SLK_HUMAN
NC score	0.017618 (rank : 246)	θ value	0.125558 (rank : 91)
Query Neighborhood Hits	217	Target Neighborhood Hits	1775	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

DYH5_HUMAN
NC score	0.017375 (rank : 247)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	217	Target Neighborhood Hits	323	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

UBF1_MOUSE
NC score	0.017374 (rank : 248)	θ value	6.88961 (rank : 195)
Query Neighborhood Hits	217	Target Neighborhood Hits	419	Shared Neighborhood Hits	29
SwissProt Accessions	P25976	Gene names	Ubtf, Tcfubf, Ubf-1, Ubf1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1).

GMIP_MOUSE
NC score	0.017287 (rank : 249)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	217	Target Neighborhood Hits	202	Shared Neighborhood Hits	17
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

DCTN4_MOUSE
NC score	0.016964 (rank : 250)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	217	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CBY8, Q923A0, Q9D4X0	Gene names	Dctn4
Domain Architecture	No domain graphic available
Description	Dynactin subunit 4 (Dynactin subunit p62).

CHD4_MOUSE
NC score	0.016678 (rank : 251)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	217	Target Neighborhood Hits	408	Shared Neighborhood Hits	19
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

NRIP1_HUMAN
NC score	0.016548 (rank : 252)	θ value	6.88961 (rank : 186)
Query Neighborhood Hits	217	Target Neighborhood Hits	88	Shared Neighborhood Hits	11
SwissProt Accessions	P48552, Q8IWE8	Gene names	NRIP1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

SLK_MOUSE
NC score	0.016432 (rank : 253)	θ value	0.47712 (rank : 103)
Query Neighborhood Hits	217	Target Neighborhood Hits	1798	Shared Neighborhood Hits	55
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

BRD3_HUMAN
NC score	0.016416 (rank : 254)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	217	Target Neighborhood Hits	369	Shared Neighborhood Hits	25
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

MYCPP_HUMAN
NC score	0.016210 (rank : 255)	θ value	2.36792 (rank : 128)
Query Neighborhood Hits	217	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z401, Q14655, Q86T77, Q8IVX2, Q8NB93	Gene names	MYCPBP, IRLB
Domain Architecture	No domain graphic available
Description	C-myc promoter-binding protein.

WDR34_HUMAN
NC score	0.015954 (rank : 256)	θ value	5.27518 (rank : 175)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	4
SwissProt Accessions	Q96EX3, Q5VXV4, Q9BV46	Gene names	WDR34
Domain Architecture
Description	WD repeat protein 34.

AIM1_HUMAN
NC score	0.015810 (rank : 257)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	217	Target Neighborhood Hits	247	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

BCAR1_HUMAN
NC score	0.015750 (rank : 258)	θ value	4.03905 (rank : 149)
Query Neighborhood Hits	217	Target Neighborhood Hits	554	Shared Neighborhood Hits	25
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ZYX_HUMAN
NC score	0.015701 (rank : 259)	θ value	0.21417 (rank : 97)
Query Neighborhood Hits	217	Target Neighborhood Hits	387	Shared Neighborhood Hits	8
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

ZCPW1_HUMAN
NC score	0.015688 (rank : 260)	θ value	5.27518 (rank : 176)
Query Neighborhood Hits	217	Target Neighborhood Hits	116	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

DCP1A_HUMAN
NC score	0.015356 (rank : 261)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	217	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

R3HD1_HUMAN
NC score	0.015187 (rank : 262)	θ value	8.99809 (rank : 208)
Query Neighborhood Hits	217	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

F125A_MOUSE
NC score	0.014638 (rank : 263)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	217	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q78HU3	Gene names	Fam125a
Domain Architecture	No domain graphic available
Description	Protein FAM125A.

SET1A_HUMAN
NC score	0.014274 (rank : 264)	θ value	6.88961 (rank : 191)
Query Neighborhood Hits	217	Target Neighborhood Hits	690	Shared Neighborhood Hits	26
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

PLCB3_MOUSE
NC score	0.013906 (rank : 265)	θ value	6.88961 (rank : 189)
Query Neighborhood Hits	217	Target Neighborhood Hits	344	Shared Neighborhood Hits	27
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PTN23_HUMAN
NC score	0.013149 (rank : 266)	θ value	8.99809 (rank : 207)
Query Neighborhood Hits	217	Target Neighborhood Hits	646	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

RERE_HUMAN
NC score	0.012896 (rank : 267)	θ value	5.27518 (rank : 171)
Query Neighborhood Hits	217	Target Neighborhood Hits	779	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

WDHD1_MOUSE
NC score	0.012883 (rank : 268)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	217	Target Neighborhood Hits	414	Shared Neighborhood Hits	15
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

STON2_HUMAN
NC score	0.012816 (rank : 269)	θ value	4.03905 (rank : 160)
Query Neighborhood Hits	217	Target Neighborhood Hits	115	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

ZO2_MOUSE
NC score	0.012637 (rank : 270)	θ value	5.27518 (rank : 177)
Query Neighborhood Hits	217	Target Neighborhood Hits	296	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

DDX21_MOUSE
NC score	0.012455 (rank : 271)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	217	Target Neighborhood Hits	350	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

SI1L2_HUMAN
NC score	0.012252 (rank : 272)	θ value	5.27518 (rank : 172)
Query Neighborhood Hits	217	Target Neighborhood Hits	131	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

MCPH1_MOUSE
NC score	0.012117 (rank : 273)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	217	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

LIMA1_MOUSE
NC score	0.012086 (rank : 274)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	217	Target Neighborhood Hits	298	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ERG0, Q9ERG1	Gene names	Lima1, D15Ertd366e, Eplin
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN).

NCOAT_MOUSE
NC score	0.011901 (rank : 275)	θ value	6.88961 (rank : 185)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQQ9, Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7	Gene names	Mgea5, Hexc, Kiaa0679
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

CHD4_HUMAN
NC score	0.010947 (rank : 276)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	217	Target Neighborhood Hits	365	Shared Neighborhood Hits	16
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CAC1I_HUMAN
NC score	0.010852 (rank : 277)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

VCAM1_MOUSE
NC score	0.010734 (rank : 278)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	217	Target Neighborhood Hits	320	Shared Neighborhood Hits	5
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

ANKS6_HUMAN
NC score	0.010344 (rank : 279)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	217	Target Neighborhood Hits	411	Shared Neighborhood Hits	6
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

PRGC2_HUMAN
NC score	0.010120 (rank : 280)	θ value	6.88961 (rank : 190)
Query Neighborhood Hits	217	Target Neighborhood Hits	272	Shared Neighborhood Hits	9
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

STAU1_HUMAN
NC score	0.009053 (rank : 281)	θ value	6.88961 (rank : 193)
Query Neighborhood Hits	217	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	O95793, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2	Gene names	STAU1, STAU
Domain Architecture
Description	Double-stranded RNA-binding protein Staufen homolog 1.

PAX8_HUMAN
NC score	0.008538 (rank : 282)	θ value	3.0926 (rank : 141)
Query Neighborhood Hits	217	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q06710, Q09155, Q16337, Q16338, Q16339, Q96J49	Gene names	PAX8
Domain Architecture
Description	Paired box protein Pax-8.

SFRS4_HUMAN
NC score	0.007824 (rank : 283)	θ value	8.99809 (rank : 209)
Query Neighborhood Hits	217	Target Neighborhood Hits	384	Shared Neighborhood Hits	14
SwissProt Accessions	Q08170, Q5VXP1, Q9BUA4, Q9UEB5	Gene names	SFRS4, SRP75
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB).

NRDC_MOUSE
NC score	0.007100 (rank : 284)	θ value	8.99809 (rank : 206)
Query Neighborhood Hits	217	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

UBP34_HUMAN
NC score	0.006966 (rank : 285)	θ value	6.88961 (rank : 196)
Query Neighborhood Hits	217	Target Neighborhood Hits	210	Shared Neighborhood Hits	10
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

SOX12_HUMAN
NC score	0.006909 (rank : 286)	θ value	6.88961 (rank : 192)
Query Neighborhood Hits	217	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	O15370, Q9NUD4	Gene names	SOX12, SOX22
Domain Architecture
Description	SOX-12 protein (SOX-22 protein).

FREA_MOUSE
NC score	0.006533 (rank : 287)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	217	Target Neighborhood Hits	147	Shared Neighborhood Hits	5
SwissProt Accessions	Q61574, Q8C5N7	Gene names	Fkhl18, Fkh3, Freac10
Domain Architecture	No domain graphic available
Description	Forkhead-related transcription factor 10 (FREAC-10) (Forkhead-like 18 protein) (Transcription factor FKH-3).

PTPRG_HUMAN
NC score	0.003816 (rank : 288)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	217	Target Neighborhood Hits	231	Shared Neighborhood Hits	11
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

NEK1_MOUSE
NC score	0.003325 (rank : 289)	θ value	2.36792 (rank : 129)
Query Neighborhood Hits	217	Target Neighborhood Hits	1311	Shared Neighborhood Hits	37
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

ZN507_HUMAN
NC score	0.003002 (rank : 290)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	217	Target Neighborhood Hits	739	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

KKCC2_MOUSE
NC score	0.000636 (rank : 291)	θ value	0.813845 (rank : 108)
Query Neighborhood Hits	217	Target Neighborhood Hits	855	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

TITIN_HUMAN
NC score	0.000441 (rank : 292)	θ value	6.88961 (rank : 194)
Query Neighborhood Hits	217	Target Neighborhood Hits	2923	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

PASK_MOUSE
NC score	0.000305 (rank : 293)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

ZNF70_HUMAN
NC score	-0.000225 (rank : 294)	θ value	0.279714 (rank : 98)
Query Neighborhood Hits	217	Target Neighborhood Hits	760	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

ZN323_HUMAN
NC score	-0.000458 (rank : 295)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	217	Target Neighborhood Hits	802	Shared Neighborhood Hits	19
SwissProt Accessions	Q96LW9, Q8WWS5	Gene names	ZNF323
Domain Architecture
Description	Zinc finger protein 323.

OXSR1_HUMAN
NC score	-0.001743 (rank : 296)	θ value	6.88961 (rank : 187)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ZNF8_HUMAN
NC score	-0.003461 (rank : 297)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	217	Target Neighborhood Hits	748	Shared Neighborhood Hits	9
SwissProt Accessions	P17098, Q6PI99	Gene names	ZNF8
Domain Architecture	No domain graphic available
Description	Zinc finger protein 8 (Zinc finger protein HF.18).

ZN434_HUMAN
NC score	-0.004121 (rank : 298)	θ value	6.88961 (rank : 198)
Query Neighborhood Hits	217	Target Neighborhood Hits	747	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NX65, Q7Z6G2	Gene names	ZNF434
Domain Architecture
Description	Zinc finger protein 434.

ZN483_HUMAN
NC score	-0.004261 (rank : 299)	θ value	6.88961 (rank : 199)
Query Neighborhood Hits	217	Target Neighborhood Hits	785	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TF39	Gene names	ZNF483, KIAA1962
Domain Architecture
Description	Zinc finger protein 483.