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Network neighborhood for query Sequence : DVL1L_HUMAN

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DVL1L_HUMAN
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DVL1L_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	146	Target Neighborhood Hits	146	Shared Neighborhood Hits	146
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	0 (rank : 2)	NC score	0.996947 (rank : 2)
Query Neighborhood Hits	146	Target Neighborhood Hits	158	Shared Neighborhood Hits	136
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	0 (rank : 3)	NC score	0.995972 (rank : 3)
Query Neighborhood Hits	146	Target Neighborhood Hits	146	Shared Neighborhood Hits	130
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL2_MOUSE
θ value	1.79118e-157 (rank : 4)	NC score	0.972390 (rank : 6)
Query Neighborhood Hits	146	Target Neighborhood Hits	233	Shared Neighborhood Hits	122
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
θ value	1.41924e-154 (rank : 5)	NC score	0.974009 (rank : 4)
Query Neighborhood Hits	146	Target Neighborhood Hits	223	Shared Neighborhood Hits	122
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_MOUSE
θ value	6.03229e-113 (rank : 6)	NC score	0.972827 (rank : 5)
Query Neighborhood Hits	146	Target Neighborhood Hits	198	Shared Neighborhood Hits	124
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
θ value	1.34386e-112 (rank : 7)	NC score	0.971745 (rank : 7)
Query Neighborhood Hits	146	Target Neighborhood Hits	194	Shared Neighborhood Hits	124
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DLG2_MOUSE
θ value	3.41135e-07 (rank : 8)	NC score	0.443002 (rank : 20)
Query Neighborhood Hits	146	Target Neighborhood Hits	271	Shared Neighborhood Hits	115
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PARD3_HUMAN
θ value	3.41135e-07 (rank : 9)	NC score	0.496134 (rank : 10)
Query Neighborhood Hits	146	Target Neighborhood Hits	312	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

LNX2_HUMAN
θ value	5.81887e-07 (rank : 10)	NC score	0.465332 (rank : 16)
Query Neighborhood Hits	146	Target Neighborhood Hits	389	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	5.81887e-07 (rank : 11)	NC score	0.471508 (rank : 14)
Query Neighborhood Hits	146	Target Neighborhood Hits	407	Shared Neighborhood Hits	113
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

PTN13_HUMAN
θ value	5.81887e-07 (rank : 12)	NC score	0.292435 (rank : 76)
Query Neighborhood Hits	146	Target Neighborhood Hits	471	Shared Neighborhood Hits	115
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

DLG2_HUMAN
θ value	7.59969e-07 (rank : 13)	NC score	0.439726 (rank : 24)
Query Neighborhood Hits	146	Target Neighborhood Hits	279	Shared Neighborhood Hits	115
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PAR3L_HUMAN
θ value	7.59969e-07 (rank : 14)	NC score	0.498668 (rank : 9)
Query Neighborhood Hits	146	Target Neighborhood Hits	297	Shared Neighborhood Hits	114
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

DLG4_HUMAN
θ value	9.92553e-07 (rank : 15)	NC score	0.440706 (rank : 23)
Query Neighborhood Hits	146	Target Neighborhood Hits	286	Shared Neighborhood Hits	116
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	9.92553e-07 (rank : 16)	NC score	0.441329 (rank : 21)
Query Neighborhood Hits	146	Target Neighborhood Hits	282	Shared Neighborhood Hits	116
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG3_HUMAN
θ value	1.69304e-06 (rank : 17)	NC score	0.434397 (rank : 27)
Query Neighborhood Hits	146	Target Neighborhood Hits	269	Shared Neighborhood Hits	115
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	1.69304e-06 (rank : 18)	NC score	0.436836 (rank : 26)
Query Neighborhood Hits	146	Target Neighborhood Hits	274	Shared Neighborhood Hits	115
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

INADL_HUMAN
θ value	1.69304e-06 (rank : 19)	NC score	0.477973 (rank : 12)
Query Neighborhood Hits	146	Target Neighborhood Hits	260	Shared Neighborhood Hits	115
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MPDZ_HUMAN
θ value	1.69304e-06 (rank : 20)	NC score	0.471535 (rank : 13)
Query Neighborhood Hits	146	Target Neighborhood Hits	261	Shared Neighborhood Hits	115
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PTN13_MOUSE
θ value	1.69304e-06 (rank : 21)	NC score	0.279699 (rank : 81)
Query Neighborhood Hits	146	Target Neighborhood Hits	426	Shared Neighborhood Hits	115
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

SYJ2B_HUMAN
θ value	2.88788e-06 (rank : 22)	NC score	0.563933 (rank : 8)
Query Neighborhood Hits	146	Target Neighborhood Hits	162	Shared Neighborhood Hits	105
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

DLG1_HUMAN
θ value	4.92598e-06 (rank : 23)	NC score	0.429741 (rank : 28)
Query Neighborhood Hits	146	Target Neighborhood Hits	290	Shared Neighborhood Hits	115
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

PARD3_MOUSE
θ value	4.92598e-06 (rank : 24)	NC score	0.493131 (rank : 11)
Query Neighborhood Hits	146	Target Neighborhood Hits	290	Shared Neighborhood Hits	118
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDZK4_HUMAN
θ value	4.92598e-06 (rank : 25)	NC score	0.413904 (rank : 30)
Query Neighborhood Hits	146	Target Neighborhood Hits	165	Shared Neighborhood Hits	95
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

DLG1_MOUSE
θ value	6.43352e-06 (rank : 26)	NC score	0.428549 (rank : 29)
Query Neighborhood Hits	146	Target Neighborhood Hits	285	Shared Neighborhood Hits	115
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

MPDZ_MOUSE
θ value	6.43352e-06 (rank : 27)	NC score	0.463466 (rank : 17)
Query Neighborhood Hits	146	Target Neighborhood Hits	298	Shared Neighborhood Hits	115
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

INADL_MOUSE
θ value	1.09739e-05 (rank : 28)	NC score	0.467202 (rank : 15)
Query Neighborhood Hits	146	Target Neighborhood Hits	290	Shared Neighborhood Hits	116
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

GRIP2_HUMAN
θ value	1.87187e-05 (rank : 29)	NC score	0.443136 (rank : 19)
Query Neighborhood Hits	146	Target Neighborhood Hits	256	Shared Neighborhood Hits	114
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

PDZD2_HUMAN
θ value	1.87187e-05 (rank : 30)	NC score	0.452765 (rank : 18)
Query Neighborhood Hits	146	Target Neighborhood Hits	772	Shared Neighborhood Hits	120
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PDZK4_MOUSE
θ value	3.19293e-05 (rank : 31)	NC score	0.409076 (rank : 33)
Query Neighborhood Hits	146	Target Neighborhood Hits	165	Shared Neighborhood Hits	98
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

LNX1_HUMAN
θ value	4.1701e-05 (rank : 32)	NC score	0.439089 (rank : 25)
Query Neighborhood Hits	146	Target Neighborhood Hits	379	Shared Neighborhood Hits	111
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
θ value	4.1701e-05 (rank : 33)	NC score	0.440745 (rank : 22)
Query Neighborhood Hits	146	Target Neighborhood Hits	377	Shared Neighborhood Hits	115
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

AFAD_HUMAN
θ value	0.000121331 (rank : 34)	NC score	0.380943 (rank : 47)
Query Neighborhood Hits	146	Target Neighborhood Hits	689	Shared Neighborhood Hits	105
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

PZRN4_HUMAN
θ value	0.000121331 (rank : 35)	NC score	0.398028 (rank : 34)
Query Neighborhood Hits	146	Target Neighborhood Hits	438	Shared Neighborhood Hits	112
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

NOS1_MOUSE
θ value	0.000158464 (rank : 36)	NC score	0.239713 (rank : 97)
Query Neighborhood Hits	146	Target Neighborhood Hits	155	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

ZO3_HUMAN
θ value	0.000158464 (rank : 37)	NC score	0.397571 (rank : 35)
Query Neighborhood Hits	146	Target Neighborhood Hits	219	Shared Neighborhood Hits	111
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

AXN2_MOUSE
θ value	0.00020696 (rank : 38)	NC score	0.229242 (rank : 100)
Query Neighborhood Hits	146	Target Neighborhood Hits	116	Shared Neighborhood Hits	15
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

NOS1_HUMAN
θ value	0.00020696 (rank : 39)	NC score	0.246542 (rank : 92)
Query Neighborhood Hits	146	Target Neighborhood Hits	218	Shared Neighborhood Hits	102
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PZRN3_HUMAN
θ value	0.000270298 (rank : 40)	NC score	0.382650 (rank : 46)
Query Neighborhood Hits	146	Target Neighborhood Hits	461	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
θ value	0.000270298 (rank : 41)	NC score	0.383307 (rank : 45)
Query Neighborhood Hits	146	Target Neighborhood Hits	447	Shared Neighborhood Hits	108
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

STXB4_MOUSE
θ value	0.00035302 (rank : 42)	NC score	0.338802 (rank : 59)
Query Neighborhood Hits	146	Target Neighborhood Hits	629	Shared Neighborhood Hits	91
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

AXN1_HUMAN
θ value	0.000602161 (rank : 43)	NC score	0.213538 (rank : 114)
Query Neighborhood Hits	146	Target Neighborhood Hits	99	Shared Neighborhood Hits	16
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

AXN2_HUMAN
θ value	0.000602161 (rank : 44)	NC score	0.220924 (rank : 109)
Query Neighborhood Hits	146	Target Neighborhood Hits	102	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2T1, Q9H3M6, Q9UH84	Gene names	AXIN2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

LAP4_MOUSE
θ value	0.000602161 (rank : 45)	NC score	0.282301 (rank : 79)
Query Neighborhood Hits	146	Target Neighborhood Hits	590	Shared Neighborhood Hits	115
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

RGS11_HUMAN
θ value	0.000602161 (rank : 46)	NC score	0.125051 (rank : 146)
Query Neighborhood Hits	146	Target Neighborhood Hits	68	Shared Neighborhood Hits	17
SwissProt Accessions	O94810, O75883	Gene names	RGS11
Domain Architecture
Description	Regulator of G-protein signaling 11 (RGS11).

ZO3_MOUSE
θ value	0.000602161 (rank : 47)	NC score	0.385329 (rank : 44)
Query Neighborhood Hits	146	Target Neighborhood Hits	224	Shared Neighborhood Hits	111
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

GRIP1_HUMAN
θ value	0.00102713 (rank : 48)	NC score	0.413258 (rank : 31)
Query Neighborhood Hits	146	Target Neighborhood Hits	231	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	0.00102713 (rank : 49)	NC score	0.411562 (rank : 32)
Query Neighborhood Hits	146	Target Neighborhood Hits	241	Shared Neighborhood Hits	115
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

LAP4_HUMAN
θ value	0.00134147 (rank : 50)	NC score	0.281295 (rank : 80)
Query Neighborhood Hits	146	Target Neighborhood Hits	608	Shared Neighborhood Hits	115
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

NEB1_HUMAN
θ value	0.00228821 (rank : 51)	NC score	0.319633 (rank : 70)
Query Neighborhood Hits	146	Target Neighborhood Hits	829	Shared Neighborhood Hits	102
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

DLG5_HUMAN
θ value	0.00298849 (rank : 52)	NC score	0.266146 (rank : 83)
Query Neighborhood Hits	146	Target Neighborhood Hits	1088	Shared Neighborhood Hits	116
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

AXN1_MOUSE
θ value	0.00390308 (rank : 53)	NC score	0.197148 (rank : 117)
Query Neighborhood Hits	146	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	O35625	Gene names	Axin1, Axin, Fu
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (Fused protein).

NEB2_HUMAN
θ value	0.00390308 (rank : 54)	NC score	0.304714 (rank : 73)
Query Neighborhood Hits	146	Target Neighborhood Hits	883	Shared Neighborhood Hits	97
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	0.00390308 (rank : 55)	NC score	0.300820 (rank : 75)
Query Neighborhood Hits	146	Target Neighborhood Hits	889	Shared Neighborhood Hits	97
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

STXB4_HUMAN
θ value	0.00509761 (rank : 56)	NC score	0.319870 (rank : 69)
Query Neighborhood Hits	146	Target Neighborhood Hits	616	Shared Neighborhood Hits	96
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

K1849_MOUSE
θ value	0.00665767 (rank : 57)	NC score	0.340726 (rank : 57)
Query Neighborhood Hits	146	Target Neighborhood Hits	335	Shared Neighborhood Hits	106
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

USH1C_HUMAN
θ value	0.00665767 (rank : 58)	NC score	0.388121 (rank : 43)
Query Neighborhood Hits	146	Target Neighborhood Hits	327	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

ZO1_MOUSE
θ value	0.00665767 (rank : 59)	NC score	0.348922 (rank : 52)
Query Neighborhood Hits	146	Target Neighborhood Hits	453	Shared Neighborhood Hits	113
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

USH1C_MOUSE
θ value	0.0113563 (rank : 60)	NC score	0.361597 (rank : 48)
Query Neighborhood Hits	146	Target Neighborhood Hits	557	Shared Neighborhood Hits	118
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

MAGI1_HUMAN
θ value	0.0193708 (rank : 61)	NC score	0.340023 (rank : 58)
Query Neighborhood Hits	146	Target Neighborhood Hits	388	Shared Neighborhood Hits	115
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	0.0193708 (rank : 62)	NC score	0.342752 (rank : 56)
Query Neighborhood Hits	146	Target Neighborhood Hits	403	Shared Neighborhood Hits	116
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	0.0193708 (rank : 63)	NC score	0.327546 (rank : 65)
Query Neighborhood Hits	146	Target Neighborhood Hits	373	Shared Neighborhood Hits	115
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	0.0193708 (rank : 64)	NC score	0.330263 (rank : 64)
Query Neighborhood Hits	146	Target Neighborhood Hits	370	Shared Neighborhood Hits	115
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

ZO1_HUMAN
θ value	0.0193708 (rank : 65)	NC score	0.343511 (rank : 55)
Query Neighborhood Hits	146	Target Neighborhood Hits	474	Shared Neighborhood Hits	113
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

K1849_HUMAN
θ value	0.0252991 (rank : 66)	NC score	0.346936 (rank : 54)
Query Neighborhood Hits	146	Target Neighborhood Hits	220	Shared Neighborhood Hits	104
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

DEPD5_HUMAN
θ value	0.0330416 (rank : 67)	NC score	0.134759 (rank : 140)
Query Neighborhood Hits	146	Target Neighborhood Hits	40	Shared Neighborhood Hits	13
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

LIN7B_HUMAN
θ value	0.0330416 (rank : 68)	NC score	0.394082 (rank : 37)
Query Neighborhood Hits	146	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7A_HUMAN
θ value	0.0431538 (rank : 69)	NC score	0.392573 (rank : 38)
Query Neighborhood Hits	146	Target Neighborhood Hits	193	Shared Neighborhood Hits	114
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	0.0431538 (rank : 70)	NC score	0.392381 (rank : 39)
Query Neighborhood Hits	146	Target Neighborhood Hits	193	Shared Neighborhood Hits	114
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_MOUSE
θ value	0.0431538 (rank : 71)	NC score	0.392063 (rank : 40)
Query Neighborhood Hits	146	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
θ value	0.0431538 (rank : 72)	NC score	0.391578 (rank : 41)
Query Neighborhood Hits	146	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	0.0431538 (rank : 73)	NC score	0.391578 (rank : 42)
Query Neighborhood Hits	146	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

RPGF6_HUMAN
θ value	0.0431538 (rank : 74)	NC score	0.247986 (rank : 90)
Query Neighborhood Hits	146	Target Neighborhood Hits	266	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SNTG2_HUMAN
θ value	0.0431538 (rank : 75)	NC score	0.337590 (rank : 61)
Query Neighborhood Hits	146	Target Neighborhood Hits	191	Shared Neighborhood Hits	109
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

GOPC_HUMAN
θ value	0.0563607 (rank : 76)	NC score	0.300830 (rank : 74)
Query Neighborhood Hits	146	Target Neighborhood Hits	377	Shared Neighborhood Hits	110
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.0563607 (rank : 77)	NC score	0.306050 (rank : 72)
Query Neighborhood Hits	146	Target Neighborhood Hits	323	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

WHRN_MOUSE
θ value	0.0563607 (rank : 78)	NC score	0.358608 (rank : 50)
Query Neighborhood Hits	146	Target Neighborhood Hits	412	Shared Neighborhood Hits	114
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

RPGF2_HUMAN
θ value	0.0736092 (rank : 79)	NC score	0.224790 (rank : 107)
Query Neighborhood Hits	146	Target Neighborhood Hits	242	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

ZO2_HUMAN
θ value	0.0736092 (rank : 80)	NC score	0.337208 (rank : 62)
Query Neighborhood Hits	146	Target Neighborhood Hits	289	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	0.0736092 (rank : 81)	NC score	0.338199 (rank : 60)
Query Neighborhood Hits	146	Target Neighborhood Hits	296	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

APBA2_HUMAN
θ value	0.125558 (rank : 82)	NC score	0.225294 (rank : 106)
Query Neighborhood Hits	146	Target Neighborhood Hits	220	Shared Neighborhood Hits	101
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.125558 (rank : 83)	NC score	0.225866 (rank : 104)
Query Neighborhood Hits	146	Target Neighborhood Hits	219	Shared Neighborhood Hits	101
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

LAP2_HUMAN
θ value	0.125558 (rank : 84)	NC score	0.161697 (rank : 130)
Query Neighborhood Hits	146	Target Neighborhood Hits	499	Shared Neighborhood Hits	86
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	0.125558 (rank : 85)	NC score	0.156041 (rank : 131)
Query Neighborhood Hits	146	Target Neighborhood Hits	482	Shared Neighborhood Hits	83
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LRRC7_HUMAN
θ value	0.125558 (rank : 86)	NC score	0.167293 (rank : 120)
Query Neighborhood Hits	146	Target Neighborhood Hits	423	Shared Neighborhood Hits	87
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	0.125558 (rank : 87)	NC score	0.166747 (rank : 121)
Query Neighborhood Hits	146	Target Neighborhood Hits	416	Shared Neighborhood Hits	87
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

WHRN_HUMAN
θ value	0.125558 (rank : 88)	NC score	0.359144 (rank : 49)
Query Neighborhood Hits	146	Target Neighborhood Hits	325	Shared Neighborhood Hits	116
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

SNTG2_MOUSE
θ value	0.163984 (rank : 89)	NC score	0.314787 (rank : 71)
Query Neighborhood Hits	146	Target Neighborhood Hits	176	Shared Neighborhood Hits	99
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

IL16_HUMAN
θ value	0.21417 (rank : 90)	NC score	0.395793 (rank : 36)
Query Neighborhood Hits	146	Target Neighborhood Hits	207	Shared Neighborhood Hits	106
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

MPP4_HUMAN
θ value	0.279714 (rank : 91)	NC score	0.266104 (rank : 84)
Query Neighborhood Hits	146	Target Neighborhood Hits	205	Shared Neighborhood Hits	101
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	0.365318 (rank : 92)	NC score	0.257143 (rank : 88)
Query Neighborhood Hits	146	Target Neighborhood Hits	188	Shared Neighborhood Hits	89
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

RGS9_MOUSE
θ value	0.365318 (rank : 93)	NC score	0.095244 (rank : 163)
Query Neighborhood Hits	146	Target Neighborhood Hits	65	Shared Neighborhood Hits	16
SwissProt Accessions	O54828, Q9Z0S0	Gene names	Rgs9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

APBA1_HUMAN
θ value	0.47712 (rank : 94)	NC score	0.228705 (rank : 101)
Query Neighborhood Hits	146	Target Neighborhood Hits	325	Shared Neighborhood Hits	104
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

FRS3_MOUSE
θ value	0.47712 (rank : 95)	NC score	0.019304 (rank : 200)
Query Neighborhood Hits	146	Target Neighborhood Hits	168	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

MPP3_HUMAN
θ value	0.47712 (rank : 96)	NC score	0.244274 (rank : 94)
Query Neighborhood Hits	146	Target Neighborhood Hits	171	Shared Neighborhood Hits	99
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	0.47712 (rank : 97)	NC score	0.246016 (rank : 93)
Query Neighborhood Hits	146	Target Neighborhood Hits	165	Shared Neighborhood Hits	99
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

PCLO_MOUSE
θ value	0.47712 (rank : 98)	NC score	0.113996 (rank : 152)
Query Neighborhood Hits	146	Target Neighborhood Hits	2275	Shared Neighborhood Hits	109
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PREX1_HUMAN
θ value	0.47712 (rank : 99)	NC score	0.058149 (rank : 185)
Query Neighborhood Hits	146	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RGS9_HUMAN
θ value	0.47712 (rank : 100)	NC score	0.097000 (rank : 160)
Query Neighborhood Hits	146	Target Neighborhood Hits	64	Shared Neighborhood Hits	17
SwissProt Accessions	O75916, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33	Gene names	RGS9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

EM55_HUMAN
θ value	0.62314 (rank : 101)	NC score	0.214393 (rank : 112)
Query Neighborhood Hits	146	Target Neighborhood Hits	228	Shared Neighborhood Hits	94
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	0.62314 (rank : 102)	NC score	0.213903 (rank : 113)
Query Neighborhood Hits	146	Target Neighborhood Hits	221	Shared Neighborhood Hits	93
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

TCGAP_HUMAN
θ value	0.62314 (rank : 103)	NC score	0.029120 (rank : 198)
Query Neighborhood Hits	146	Target Neighborhood Hits	872	Shared Neighborhood Hits	17
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

JARD2_HUMAN
θ value	0.813845 (rank : 104)	NC score	0.023502 (rank : 199)
Query Neighborhood Hits	146	Target Neighborhood Hits	119	Shared Neighborhood Hits	5
SwissProt Accessions	Q92833, Q5U5L5	Gene names	JARID2, JMJ
Domain Architecture
Description	Jumonji protein (Jumonji/ARID domain-containing protein 2).

PDZ11_HUMAN
θ value	0.813845 (rank : 105)	NC score	0.348264 (rank : 53)
Query Neighborhood Hits	146	Target Neighborhood Hits	160	Shared Neighborhood Hits	90
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

RPGF4_MOUSE
θ value	0.813845 (rank : 106)	NC score	0.059708 (rank : 182)
Query Neighborhood Hits	146	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

PDZ11_MOUSE
θ value	1.06291 (rank : 107)	NC score	0.333802 (rank : 63)
Query Neighborhood Hits	146	Target Neighborhood Hits	154	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

TX1B3_HUMAN
θ value	1.06291 (rank : 108)	NC score	0.324885 (rank : 66)
Query Neighborhood Hits	146	Target Neighborhood Hits	161	Shared Neighborhood Hits	102
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	1.06291 (rank : 109)	NC score	0.322290 (rank : 67)
Query Neighborhood Hits	146	Target Neighborhood Hits	158	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

CSKP_HUMAN
θ value	1.38821 (rank : 110)	NC score	0.064510 (rank : 175)
Query Neighborhood Hits	146	Target Neighborhood Hits	1022	Shared Neighborhood Hits	90
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	1.38821 (rank : 111)	NC score	0.062311 (rank : 179)
Query Neighborhood Hits	146	Target Neighborhood Hits	1027	Shared Neighborhood Hits	91
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

RIMS1_HUMAN
θ value	1.38821 (rank : 112)	NC score	0.135093 (rank : 139)
Query Neighborhood Hits	146	Target Neighborhood Hits	437	Shared Neighborhood Hits	88
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

IL16_MOUSE
θ value	1.81305 (rank : 113)	NC score	0.352945 (rank : 51)
Query Neighborhood Hits	146	Target Neighborhood Hits	189	Shared Neighborhood Hits	105
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

MY18A_MOUSE
θ value	1.81305 (rank : 114)	NC score	0.038561 (rank : 195)
Query Neighborhood Hits	146	Target Neighborhood Hits	1989	Shared Neighborhood Hits	94
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RPGF5_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.050531 (rank : 193)
Query Neighborhood Hits	146	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

SNTA1_HUMAN
θ value	1.81305 (rank : 116)	NC score	0.275846 (rank : 82)
Query Neighborhood Hits	146	Target Neighborhood Hits	186	Shared Neighborhood Hits	102
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTG1_MOUSE
θ value	1.81305 (rank : 117)	NC score	0.285152 (rank : 77)
Query Neighborhood Hits	146	Target Neighborhood Hits	179	Shared Neighborhood Hits	104
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

RPGF4_HUMAN
θ value	2.36792 (rank : 118)	NC score	0.051145 (rank : 192)
Query Neighborhood Hits	146	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

SNTB1_HUMAN
θ value	2.36792 (rank : 119)	NC score	0.262941 (rank : 85)
Query Neighborhood Hits	146	Target Neighborhood Hits	157	Shared Neighborhood Hits	101
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	2.36792 (rank : 120)	NC score	0.261654 (rank : 87)
Query Neighborhood Hits	146	Target Neighborhood Hits	160	Shared Neighborhood Hits	99
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTG1_HUMAN
θ value	2.36792 (rank : 121)	NC score	0.284111 (rank : 78)
Query Neighborhood Hits	146	Target Neighborhood Hits	181	Shared Neighborhood Hits	105
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

TAU_HUMAN
θ value	3.0926 (rank : 122)	NC score	0.015479 (rank : 202)
Query Neighborhood Hits	146	Target Neighborhood Hits	448	Shared Neighborhood Hits	10
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ZN592_MOUSE
θ value	3.0926 (rank : 123)	NC score	-0.001491 (rank : 211)
Query Neighborhood Hits	146	Target Neighborhood Hits	768	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BHZ4, Q80XM1	Gene names	Znf592, Kiaa0211, Zfp592
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592 (Zfp-592).

APBA3_HUMAN
θ value	5.27518 (rank : 124)	NC score	0.193268 (rank : 118)
Query Neighborhood Hits	146	Target Neighborhood Hits	201	Shared Neighborhood Hits	93
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

BCAR1_HUMAN
θ value	5.27518 (rank : 125)	NC score	0.008029 (rank : 205)
Query Neighborhood Hits	146	Target Neighborhood Hits	554	Shared Neighborhood Hits	13
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PDZD6_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.152994 (rank : 135)
Query Neighborhood Hits	146	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

SNTA1_MOUSE
θ value	5.27518 (rank : 127)	NC score	0.261697 (rank : 86)
Query Neighborhood Hits	146	Target Neighborhood Hits	170	Shared Neighborhood Hits	101
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

DEPD5_MOUSE
θ value	6.88961 (rank : 128)	NC score	0.080579 (rank : 168)
Query Neighborhood Hits	146	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

MRCKB_MOUSE
θ value	6.88961 (rank : 129)	NC score	-0.001282 (rank : 210)
Query Neighborhood Hits	146	Target Neighborhood Hits	2180	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PLEK_MOUSE
θ value	6.88961 (rank : 130)	NC score	0.042027 (rank : 194)
Query Neighborhood Hits	146	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

SSBP4_HUMAN
θ value	6.88961 (rank : 131)	NC score	0.012751 (rank : 204)
Query Neighborhood Hits	146	Target Neighborhood Hits	753	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

ZBTB5_HUMAN
θ value	6.88961 (rank : 132)	NC score	-0.002747 (rank : 213)
Query Neighborhood Hits	146	Target Neighborhood Hits	811	Shared Neighborhood Hits	4
SwissProt Accessions	O15062	Gene names	ZBTB5, KIAA0354
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 5.

ANK3_HUMAN
θ value	8.99809 (rank : 133)	NC score	-0.000916 (rank : 209)
Query Neighborhood Hits	146	Target Neighborhood Hits	853	Shared Neighborhood Hits	7
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

FYV1_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.029779 (rank : 197)
Query Neighborhood Hits	146	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

LYST_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.004773 (rank : 208)
Query Neighborhood Hits	146	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

MPP5_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.227711 (rank : 102)
Query Neighborhood Hits	146	Target Neighborhood Hits	231	Shared Neighborhood Hits	102
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	8.99809 (rank : 137)	NC score	0.227100 (rank : 103)
Query Neighborhood Hits	146	Target Neighborhood Hits	226	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MRCKB_HUMAN
θ value	8.99809 (rank : 138)	NC score	-0.001618 (rank : 212)
Query Neighborhood Hits	146	Target Neighborhood Hits	2239	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MY18A_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.033707 (rank : 196)
Query Neighborhood Hits	146	Target Neighborhood Hits	1929	Shared Neighborhood Hits	93
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NHRF2_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.232537 (rank : 99)
Query Neighborhood Hits	146	Target Neighborhood Hits	197	Shared Neighborhood Hits	101
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	8.99809 (rank : 141)	NC score	0.225556 (rank : 105)
Query Neighborhood Hits	146	Target Neighborhood Hits	194	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

RGS12_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.144075 (rank : 137)
Query Neighborhood Hits	146	Target Neighborhood Hits	333	Shared Neighborhood Hits	90
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

SOCS6_MOUSE
θ value	8.99809 (rank : 143)	NC score	0.004870 (rank : 207)
Query Neighborhood Hits	146	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SYNG_MOUSE
θ value	8.99809 (rank : 144)	NC score	0.007467 (rank : 206)
Query Neighborhood Hits	146	Target Neighborhood Hits	206	Shared Neighborhood Hits	6
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

TEX15_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.017620 (rank : 201)
Query Neighborhood Hits	146	Target Neighborhood Hits	174	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BXT5	Gene names	TEX15
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 15 protein.

TR150_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.014110 (rank : 203)
Query Neighborhood Hits	146	Target Neighborhood Hits	313	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

APBA3_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.171836 (rank : 119)
Query Neighborhood Hits	146	Target Neighborhood Hits	174	Shared Neighborhood Hits	90
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APXL_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.095696 (rank : 162)
Query Neighborhood Hits	146	Target Neighborhood Hits	553	Shared Neighborhood Hits	63
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARHGB_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.130412 (rank : 143)
Query Neighborhood Hits	146	Target Neighborhood Hits	375	Shared Neighborhood Hits	100
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.110369 (rank : 154)
Query Neighborhood Hits	146	Target Neighborhood Hits	351	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.111041 (rank : 153)
Query Neighborhood Hits	146	Target Neighborhood Hits	344	Shared Neighborhood Hits	92
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GIPC1_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.090778 (rank : 165)
Query Neighborhood Hits	146	Target Neighborhood Hits	91	Shared Neighborhood Hits	67
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

GIPC1_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.096904 (rank : 161)
Query Neighborhood Hits	146	Target Neighborhood Hits	92	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GIPC2_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.072793 (rank : 170)
Query Neighborhood Hits	146	Target Neighborhood Hits	93	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GRASP_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.126369 (rank : 145)
Query Neighborhood Hits	146	Target Neighborhood Hits	147	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.122756 (rank : 147)
Query Neighborhood Hits	146	Target Neighborhood Hits	131	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

KGUA_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.131415 (rank : 142)
Query Neighborhood Hits	146	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.132386 (rank : 141)
Query Neighborhood Hits	146	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LDB3_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.056204 (rank : 188)
Query Neighborhood Hits	146	Target Neighborhood Hits	497	Shared Neighborhood Hits	64
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.057242 (rank : 186)
Query Neighborhood Hits	146	Target Neighborhood Hits	510	Shared Neighborhood Hits	63
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

MPP2_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.163021 (rank : 128)
Query Neighborhood Hits	146	Target Neighborhood Hits	173	Shared Neighborhood Hits	69
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.165690 (rank : 123)
Query Neighborhood Hits	146	Target Neighborhood Hits	189	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP6_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.164478 (rank : 124)
Query Neighborhood Hits	146	Target Neighborhood Hits	180	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.166207 (rank : 122)
Query Neighborhood Hits	146	Target Neighborhood Hits	187	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NHERF_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.222574 (rank : 108)
Query Neighborhood Hits	146	Target Neighborhood Hits	190	Shared Neighborhood Hits	99
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.234907 (rank : 98)
Query Neighborhood Hits	146	Target Neighborhood Hits	195	Shared Neighborhood Hits	98
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PAR6A_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.155027 (rank : 132)
Query Neighborhood Hits	146	Target Neighborhood Hits	119	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.154636 (rank : 134)
Query Neighborhood Hits	146	Target Neighborhood Hits	115	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6B_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.163902 (rank : 126)
Query Neighborhood Hits	146	Target Neighborhood Hits	126	Shared Neighborhood Hits	92
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.164130 (rank : 125)
Query Neighborhood Hits	146	Target Neighborhood Hits	128	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.162975 (rank : 129)
Query Neighborhood Hits	146	Target Neighborhood Hits	159	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.163446 (rank : 127)
Query Neighborhood Hits	146	Target Neighborhood Hits	121	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PDLI1_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.063229 (rank : 177)
Query Neighborhood Hits	146	Target Neighborhood Hits	242	Shared Neighborhood Hits	56
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.063608 (rank : 176)
Query Neighborhood Hits	146	Target Neighborhood Hits	213	Shared Neighborhood Hits	55
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.140060 (rank : 138)
Query Neighborhood Hits	146	Target Neighborhood Hits	245	Shared Neighborhood Hits	79
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI2_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.116647 (rank : 149)
Query Neighborhood Hits	146	Target Neighborhood Hits	220	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDLI3_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.076366 (rank : 169)
Query Neighborhood Hits	146	Target Neighborhood Hits	199	Shared Neighborhood Hits	67
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.066314 (rank : 174)
Query Neighborhood Hits	146	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.071062 (rank : 172)
Query Neighborhood Hits	146	Target Neighborhood Hits	245	Shared Neighborhood Hits	63
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.072208 (rank : 171)
Query Neighborhood Hits	146	Target Neighborhood Hits	233	Shared Neighborhood Hits	64
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI5_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.059248 (rank : 184)
Query Neighborhood Hits	146	Target Neighborhood Hits	322	Shared Neighborhood Hits	68
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.059474 (rank : 183)
Query Neighborhood Hits	146	Target Neighborhood Hits	287	Shared Neighborhood Hits	68
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDZD1_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.247740 (rank : 91)
Query Neighborhood Hits	146	Target Neighborhood Hits	190	Shared Neighborhood Hits	98
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.250924 (rank : 89)
Query Neighborhood Hits	146	Target Neighborhood Hits	191	Shared Neighborhood Hits	98
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD3_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.217051 (rank : 110)
Query Neighborhood Hits	146	Target Neighborhood Hits	180	Shared Neighborhood Hits	98
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PDZD3_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.201517 (rank : 116)
Query Neighborhood Hits	146	Target Neighborhood Hits	171	Shared Neighborhood Hits	96
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PDZD7_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.321248 (rank : 68)
Query Neighborhood Hits	146	Target Neighborhood Hits	181	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PICK1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.212951 (rank : 115)
Query Neighborhood Hits	146	Target Neighborhood Hits	132	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.215499 (rank : 111)
Query Neighborhood Hits	146	Target Neighborhood Hits	131	Shared Neighborhood Hits	93
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PRAX_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.052932 (rank : 191)
Query Neighborhood Hits	146	Target Neighborhood Hits	199	Shared Neighborhood Hits	35
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

PSCBP_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.103496 (rank : 155)
Query Neighborhood Hits	146	Target Neighborhood Hits	123	Shared Neighborhood Hits	70
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PSCBP_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.114682 (rank : 151)
Query Neighborhood Hits	146	Target Neighborhood Hits	118	Shared Neighborhood Hits	69
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PTN3_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.056826 (rank : 187)
Query Neighborhood Hits	146	Target Neighborhood Hits	258	Shared Neighborhood Hits	74
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN4_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.062737 (rank : 178)
Query Neighborhood Hits	146	Target Neighborhood Hits	303	Shared Neighborhood Hits	80
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

RHPN1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.103104 (rank : 156)
Query Neighborhood Hits	146	Target Neighborhood Hits	158	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.115195 (rank : 150)
Query Neighborhood Hits	146	Target Neighborhood Hits	154	Shared Neighborhood Hits	73
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.102228 (rank : 157)
Query Neighborhood Hits	146	Target Neighborhood Hits	342	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.099951 (rank : 159)
Query Neighborhood Hits	146	Target Neighborhood Hits	376	Shared Neighborhood Hits	80
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RNF41_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.054971 (rank : 190)
Query Neighborhood Hits	146	Target Neighborhood Hits	226	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.055091 (rank : 189)
Query Neighborhood Hits	146	Target Neighborhood Hits	224	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

SDCB1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.154831 (rank : 133)
Query Neighborhood Hits	146	Target Neighborhood Hits	150	Shared Neighborhood Hits	94
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.152730 (rank : 136)
Query Neighborhood Hits	146	Target Neighborhood Hits	144	Shared Neighborhood Hits	88
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SDCB2_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.122074 (rank : 148)
Query Neighborhood Hits	146	Target Neighborhood Hits	121	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDCB2_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.127601 (rank : 144)
Query Neighborhood Hits	146	Target Neighborhood Hits	118	Shared Neighborhood Hits	79
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SHAN1_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.060005 (rank : 181)
Query Neighborhood Hits	146	Target Neighborhood Hits	1041	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.091661 (rank : 164)
Query Neighborhood Hits	146	Target Neighborhood Hits	346	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.080730 (rank : 167)
Query Neighborhood Hits	146	Target Neighborhood Hits	446	Shared Neighborhood Hits	73
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SNTB2_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.240321 (rank : 96)
Query Neighborhood Hits	146	Target Neighborhood Hits	180	Shared Neighborhood Hits	104
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.240811 (rank : 95)
Query Neighborhood Hits	146	Target Neighborhood Hits	181	Shared Neighborhood Hits	104
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SYNP2_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.061242 (rank : 180)
Query Neighborhood Hits	146	Target Neighborhood Hits	323	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SYNP2_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.087690 (rank : 166)
Query Neighborhood Hits	146	Target Neighborhood Hits	252	Shared Neighborhood Hits	69
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SYP2L_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.102157 (rank : 158)
Query Neighborhood Hits	146	Target Neighborhood Hits	400	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SYP2L_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.066426 (rank : 173)
Query Neighborhood Hits	146	Target Neighborhood Hits	289	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

Hits sorted by NC score

DVL1L_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	146	Target Neighborhood Hits	146	Shared Neighborhood Hits	146
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
NC score	0.996947 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	146	Target Neighborhood Hits	158	Shared Neighborhood Hits	136
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
NC score	0.995972 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	146	Target Neighborhood Hits	146	Shared Neighborhood Hits	130
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL2_HUMAN
NC score	0.974009 (rank : 4)	θ value	1.41924e-154 (rank : 5)
Query Neighborhood Hits	146	Target Neighborhood Hits	223	Shared Neighborhood Hits	122
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_MOUSE
NC score	0.972827 (rank : 5)	θ value	6.03229e-113 (rank : 6)
Query Neighborhood Hits	146	Target Neighborhood Hits	198	Shared Neighborhood Hits	124
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL2_MOUSE
NC score	0.972390 (rank : 6)	θ value	1.79118e-157 (rank : 4)
Query Neighborhood Hits	146	Target Neighborhood Hits	233	Shared Neighborhood Hits	122
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
NC score	0.971745 (rank : 7)	θ value	1.34386e-112 (rank : 7)
Query Neighborhood Hits	146	Target Neighborhood Hits	194	Shared Neighborhood Hits	124
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

SYJ2B_HUMAN
NC score	0.563933 (rank : 8)	θ value	2.88788e-06 (rank : 22)
Query Neighborhood Hits	146	Target Neighborhood Hits	162	Shared Neighborhood Hits	105
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

PAR3L_HUMAN
NC score	0.498668 (rank : 9)	θ value	7.59969e-07 (rank : 14)
Query Neighborhood Hits	146	Target Neighborhood Hits	297	Shared Neighborhood Hits	114
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PARD3_HUMAN
NC score	0.496134 (rank : 10)	θ value	3.41135e-07 (rank : 9)
Query Neighborhood Hits	146	Target Neighborhood Hits	312	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
NC score	0.493131 (rank : 11)	θ value	4.92598e-06 (rank : 24)
Query Neighborhood Hits	146	Target Neighborhood Hits	290	Shared Neighborhood Hits	118
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

INADL_HUMAN
NC score	0.477973 (rank : 12)	θ value	1.69304e-06 (rank : 19)
Query Neighborhood Hits	146	Target Neighborhood Hits	260	Shared Neighborhood Hits	115
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MPDZ_HUMAN
NC score	0.471535 (rank : 13)	θ value	1.69304e-06 (rank : 20)
Query Neighborhood Hits	146	Target Neighborhood Hits	261	Shared Neighborhood Hits	115
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

LNX2_MOUSE
NC score	0.471508 (rank : 14)	θ value	5.81887e-07 (rank : 11)
Query Neighborhood Hits	146	Target Neighborhood Hits	407	Shared Neighborhood Hits	113
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

INADL_MOUSE
NC score	0.467202 (rank : 15)	θ value	1.09739e-05 (rank : 28)
Query Neighborhood Hits	146	Target Neighborhood Hits	290	Shared Neighborhood Hits	116
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

LNX2_HUMAN
NC score	0.465332 (rank : 16)	θ value	5.81887e-07 (rank : 10)
Query Neighborhood Hits	146	Target Neighborhood Hits	389	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

MPDZ_MOUSE
NC score	0.463466 (rank : 17)	θ value	6.43352e-06 (rank : 27)
Query Neighborhood Hits	146	Target Neighborhood Hits	298	Shared Neighborhood Hits	115
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

PDZD2_HUMAN
NC score	0.452765 (rank : 18)	θ value	1.87187e-05 (rank : 30)
Query Neighborhood Hits	146	Target Neighborhood Hits	772	Shared Neighborhood Hits	120
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

GRIP2_HUMAN
NC score	0.443136 (rank : 19)	θ value	1.87187e-05 (rank : 29)
Query Neighborhood Hits	146	Target Neighborhood Hits	256	Shared Neighborhood Hits	114
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

DLG2_MOUSE
NC score	0.443002 (rank : 20)	θ value	3.41135e-07 (rank : 8)
Query Neighborhood Hits	146	Target Neighborhood Hits	271	Shared Neighborhood Hits	115
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG4_MOUSE
NC score	0.441329 (rank : 21)	θ value	9.92553e-07 (rank : 16)
Query Neighborhood Hits	146	Target Neighborhood Hits	282	Shared Neighborhood Hits	116
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

LNX1_MOUSE
NC score	0.440745 (rank : 22)	θ value	4.1701e-05 (rank : 33)
Query Neighborhood Hits	146	Target Neighborhood Hits	377	Shared Neighborhood Hits	115
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

DLG4_HUMAN
NC score	0.440706 (rank : 23)	θ value	9.92553e-07 (rank : 15)
Query Neighborhood Hits	146	Target Neighborhood Hits	286	Shared Neighborhood Hits	116
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG2_HUMAN
NC score	0.439726 (rank : 24)	θ value	7.59969e-07 (rank : 13)
Query Neighborhood Hits	146	Target Neighborhood Hits	279	Shared Neighborhood Hits	115
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

LNX1_HUMAN
NC score	0.439089 (rank : 25)	θ value	4.1701e-05 (rank : 32)
Query Neighborhood Hits	146	Target Neighborhood Hits	379	Shared Neighborhood Hits	111
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

DLG3_MOUSE
NC score	0.436836 (rank : 26)	θ value	1.69304e-06 (rank : 18)
Query Neighborhood Hits	146	Target Neighborhood Hits	274	Shared Neighborhood Hits	115
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG3_HUMAN
NC score	0.434397 (rank : 27)	θ value	1.69304e-06 (rank : 17)
Query Neighborhood Hits	146	Target Neighborhood Hits	269	Shared Neighborhood Hits	115
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG1_HUMAN
NC score	0.429741 (rank : 28)	θ value	4.92598e-06 (rank : 23)
Query Neighborhood Hits	146	Target Neighborhood Hits	290	Shared Neighborhood Hits	115
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
NC score	0.428549 (rank : 29)	θ value	6.43352e-06 (rank : 26)
Query Neighborhood Hits	146	Target Neighborhood Hits	285	Shared Neighborhood Hits	115
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

PDZK4_HUMAN
NC score	0.413904 (rank : 30)	θ value	4.92598e-06 (rank : 25)
Query Neighborhood Hits	146	Target Neighborhood Hits	165	Shared Neighborhood Hits	95
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

GRIP1_HUMAN
NC score	0.413258 (rank : 31)	θ value	0.00102713 (rank : 48)
Query Neighborhood Hits	146	Target Neighborhood Hits	231	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
NC score	0.411562 (rank : 32)	θ value	0.00102713 (rank : 49)
Query Neighborhood Hits	146	Target Neighborhood Hits	241	Shared Neighborhood Hits	115
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

PDZK4_MOUSE
NC score	0.409076 (rank : 33)	θ value	3.19293e-05 (rank : 31)
Query Neighborhood Hits	146	Target Neighborhood Hits	165	Shared Neighborhood Hits	98
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PZRN4_HUMAN
NC score	0.398028 (rank : 34)	θ value	0.000121331 (rank : 35)
Query Neighborhood Hits	146	Target Neighborhood Hits	438	Shared Neighborhood Hits	112
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

ZO3_HUMAN
NC score	0.397571 (rank : 35)	θ value	0.000158464 (rank : 37)
Query Neighborhood Hits	146	Target Neighborhood Hits	219	Shared Neighborhood Hits	111
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

IL16_HUMAN
NC score	0.395793 (rank : 36)	θ value	0.21417 (rank : 90)
Query Neighborhood Hits	146	Target Neighborhood Hits	207	Shared Neighborhood Hits	106
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LIN7B_HUMAN
NC score	0.394082 (rank : 37)	θ value	0.0330416 (rank : 68)
Query Neighborhood Hits	146	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7A_HUMAN
NC score	0.392573 (rank : 38)	θ value	0.0431538 (rank : 69)
Query Neighborhood Hits	146	Target Neighborhood Hits	193	Shared Neighborhood Hits	114
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
NC score	0.392381 (rank : 39)	θ value	0.0431538 (rank : 70)
Query Neighborhood Hits	146	Target Neighborhood Hits	193	Shared Neighborhood Hits	114
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_MOUSE
NC score	0.392063 (rank : 40)	θ value	0.0431538 (rank : 71)
Query Neighborhood Hits	146	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
NC score	0.391578 (rank : 41)	θ value	0.0431538 (rank : 72)
Query Neighborhood Hits	146	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.391578 (rank : 42)	θ value	0.0431538 (rank : 73)
Query Neighborhood Hits	146	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

USH1C_HUMAN
NC score	0.388121 (rank : 43)	θ value	0.00665767 (rank : 58)
Query Neighborhood Hits	146	Target Neighborhood Hits	327	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

ZO3_MOUSE
NC score	0.385329 (rank : 44)	θ value	0.000602161 (rank : 47)
Query Neighborhood Hits	146	Target Neighborhood Hits	224	Shared Neighborhood Hits	111
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

PZRN3_MOUSE
NC score	0.383307 (rank : 45)	θ value	0.000270298 (rank : 41)
Query Neighborhood Hits	146	Target Neighborhood Hits	447	Shared Neighborhood Hits	108
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_HUMAN
NC score	0.382650 (rank : 46)	θ value	0.000270298 (rank : 40)
Query Neighborhood Hits	146	Target Neighborhood Hits	461	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

AFAD_HUMAN
NC score	0.380943 (rank : 47)	θ value	0.000121331 (rank : 34)
Query Neighborhood Hits	146	Target Neighborhood Hits	689	Shared Neighborhood Hits	105
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

USH1C_MOUSE
NC score	0.361597 (rank : 48)	θ value	0.0113563 (rank : 60)
Query Neighborhood Hits	146	Target Neighborhood Hits	557	Shared Neighborhood Hits	118
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

WHRN_HUMAN
NC score	0.359144 (rank : 49)	θ value	0.125558 (rank : 88)
Query Neighborhood Hits	146	Target Neighborhood Hits	325	Shared Neighborhood Hits	116
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.358608 (rank : 50)	θ value	0.0563607 (rank : 78)
Query Neighborhood Hits	146	Target Neighborhood Hits	412	Shared Neighborhood Hits	114
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

IL16_MOUSE
NC score	0.352945 (rank : 51)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	146	Target Neighborhood Hits	189	Shared Neighborhood Hits	105
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

ZO1_MOUSE
NC score	0.348922 (rank : 52)	θ value	0.00665767 (rank : 59)
Query Neighborhood Hits	146	Target Neighborhood Hits	453	Shared Neighborhood Hits	113
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

PDZ11_HUMAN
NC score	0.348264 (rank : 53)	θ value	0.813845 (rank : 105)
Query Neighborhood Hits	146	Target Neighborhood Hits	160	Shared Neighborhood Hits	90
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

K1849_HUMAN
NC score	0.346936 (rank : 54)	θ value	0.0252991 (rank : 66)
Query Neighborhood Hits	146	Target Neighborhood Hits	220	Shared Neighborhood Hits	104
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

ZO1_HUMAN
NC score	0.343511 (rank : 55)	θ value	0.0193708 (rank : 65)
Query Neighborhood Hits	146	Target Neighborhood Hits	474	Shared Neighborhood Hits	113
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MAGI1_MOUSE
NC score	0.342752 (rank : 56)	θ value	0.0193708 (rank : 62)
Query Neighborhood Hits	146	Target Neighborhood Hits	403	Shared Neighborhood Hits	116
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

K1849_MOUSE
NC score	0.340726 (rank : 57)	θ value	0.00665767 (rank : 57)
Query Neighborhood Hits	146	Target Neighborhood Hits	335	Shared Neighborhood Hits	106
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MAGI1_HUMAN
NC score	0.340023 (rank : 58)	θ value	0.0193708 (rank : 61)
Query Neighborhood Hits	146	Target Neighborhood Hits	388	Shared Neighborhood Hits	115
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

STXB4_MOUSE
NC score	0.338802 (rank : 59)	θ value	0.00035302 (rank : 42)
Query Neighborhood Hits	146	Target Neighborhood Hits	629	Shared Neighborhood Hits	91
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

ZO2_MOUSE
NC score	0.338199 (rank : 60)	θ value	0.0736092 (rank : 81)
Query Neighborhood Hits	146	Target Neighborhood Hits	296	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

SNTG2_HUMAN
NC score	0.337590 (rank : 61)	θ value	0.0431538 (rank : 75)
Query Neighborhood Hits	146	Target Neighborhood Hits	191	Shared Neighborhood Hits	109
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

ZO2_HUMAN
NC score	0.337208 (rank : 62)	θ value	0.0736092 (rank : 80)
Query Neighborhood Hits	146	Target Neighborhood Hits	289	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

PDZ11_MOUSE
NC score	0.333802 (rank : 63)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	146	Target Neighborhood Hits	154	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

MAGI2_MOUSE
NC score	0.330263 (rank : 64)	θ value	0.0193708 (rank : 64)
Query Neighborhood Hits	146	Target Neighborhood Hits	370	Shared Neighborhood Hits	115
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.327546 (rank : 65)	θ value	0.0193708 (rank : 63)
Query Neighborhood Hits	146	Target Neighborhood Hits	373	Shared Neighborhood Hits	115
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

TX1B3_HUMAN
NC score	0.324885 (rank : 66)	θ value	1.06291 (rank : 108)
Query Neighborhood Hits	146	Target Neighborhood Hits	161	Shared Neighborhood Hits	102
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.322290 (rank : 67)	θ value	1.06291 (rank : 109)
Query Neighborhood Hits	146	Target Neighborhood Hits	158	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

PDZD7_HUMAN
NC score	0.321248 (rank : 68)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	146	Target Neighborhood Hits	181	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

STXB4_HUMAN
NC score	0.319870 (rank : 69)	θ value	0.00509761 (rank : 56)
Query Neighborhood Hits	146	Target Neighborhood Hits	616	Shared Neighborhood Hits	96
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

NEB1_HUMAN
NC score	0.319633 (rank : 70)	θ value	0.00228821 (rank : 51)
Query Neighborhood Hits	146	Target Neighborhood Hits	829	Shared Neighborhood Hits	102
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

SNTG2_MOUSE
NC score	0.314787 (rank : 71)	θ value	0.163984 (rank : 89)
Query Neighborhood Hits	146	Target Neighborhood Hits	176	Shared Neighborhood Hits	99
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

GOPC_MOUSE
NC score	0.306050 (rank : 72)	θ value	0.0563607 (rank : 77)
Query Neighborhood Hits	146	Target Neighborhood Hits	323	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

NEB2_HUMAN
NC score	0.304714 (rank : 73)	θ value	0.00390308 (rank : 54)
Query Neighborhood Hits	146	Target Neighborhood Hits	883	Shared Neighborhood Hits	97
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

GOPC_HUMAN
NC score	0.300830 (rank : 74)	θ value	0.0563607 (rank : 76)
Query Neighborhood Hits	146	Target Neighborhood Hits	377	Shared Neighborhood Hits	110
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

NEB2_MOUSE
NC score	0.300820 (rank : 75)	θ value	0.00390308 (rank : 55)
Query Neighborhood Hits	146	Target Neighborhood Hits	889	Shared Neighborhood Hits	97
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PTN13_HUMAN
NC score	0.292435 (rank : 76)	θ value	5.81887e-07 (rank : 12)
Query Neighborhood Hits	146	Target Neighborhood Hits	471	Shared Neighborhood Hits	115
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

SNTG1_MOUSE
NC score	0.285152 (rank : 77)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	146	Target Neighborhood Hits	179	Shared Neighborhood Hits	104
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_HUMAN
NC score	0.284111 (rank : 78)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	146	Target Neighborhood Hits	181	Shared Neighborhood Hits	105
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

LAP4_MOUSE
NC score	0.282301 (rank : 79)	θ value	0.000602161 (rank : 45)
Query Neighborhood Hits	146	Target Neighborhood Hits	590	Shared Neighborhood Hits	115
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LAP4_HUMAN
NC score	0.281295 (rank : 80)	θ value	0.00134147 (rank : 50)
Query Neighborhood Hits	146	Target Neighborhood Hits	608	Shared Neighborhood Hits	115
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

PTN13_MOUSE
NC score	0.279699 (rank : 81)	θ value	1.69304e-06 (rank : 21)
Query Neighborhood Hits	146	Target Neighborhood Hits	426	Shared Neighborhood Hits	115
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

SNTA1_HUMAN
NC score	0.275846 (rank : 82)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	146	Target Neighborhood Hits	186	Shared Neighborhood Hits	102
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

DLG5_HUMAN
NC score	0.266146 (rank : 83)	θ value	0.00298849 (rank : 52)
Query Neighborhood Hits	146	Target Neighborhood Hits	1088	Shared Neighborhood Hits	116
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

MPP4_HUMAN
NC score	0.266104 (rank : 84)	θ value	0.279714 (rank : 91)
Query Neighborhood Hits	146	Target Neighborhood Hits	205	Shared Neighborhood Hits	101
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

SNTB1_HUMAN
NC score	0.262941 (rank : 85)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	146	Target Neighborhood Hits	157	Shared Neighborhood Hits	101
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTA1_MOUSE
NC score	0.261697 (rank : 86)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	146	Target Neighborhood Hits	170	Shared Neighborhood Hits	101
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTB1_MOUSE
NC score	0.261654 (rank : 87)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	146	Target Neighborhood Hits	160	Shared Neighborhood Hits	99
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

MPP4_MOUSE
NC score	0.257143 (rank : 88)	θ value	0.365318 (rank : 92)
Query Neighborhood Hits	146	Target Neighborhood Hits	188	Shared Neighborhood Hits	89
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PDZD1_MOUSE
NC score	0.250924 (rank : 89)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	146	Target Neighborhood Hits	191	Shared Neighborhood Hits	98
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

RPGF6_HUMAN
NC score	0.247986 (rank : 90)	θ value	0.0431538 (rank : 74)
Query Neighborhood Hits	146	Target Neighborhood Hits	266	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PDZD1_HUMAN
NC score	0.247740 (rank : 91)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	146	Target Neighborhood Hits	190	Shared Neighborhood Hits	98
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

NOS1_HUMAN
NC score	0.246542 (rank : 92)	θ value	0.00020696 (rank : 39)
Query Neighborhood Hits	146	Target Neighborhood Hits	218	Shared Neighborhood Hits	102
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

MPP3_MOUSE
NC score	0.246016 (rank : 93)	θ value	0.47712 (rank : 97)
Query Neighborhood Hits	146	Target Neighborhood Hits	165	Shared Neighborhood Hits	99
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP3_HUMAN
NC score	0.244274 (rank : 94)	θ value	0.47712 (rank : 96)
Query Neighborhood Hits	146	Target Neighborhood Hits	171	Shared Neighborhood Hits	99
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

SNTB2_MOUSE
NC score	0.240811 (rank : 95)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	146	Target Neighborhood Hits	181	Shared Neighborhood Hits	104
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_HUMAN
NC score	0.240321 (rank : 96)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	146	Target Neighborhood Hits	180	Shared Neighborhood Hits	104
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

NOS1_MOUSE
NC score	0.239713 (rank : 97)	θ value	0.000158464 (rank : 36)
Query Neighborhood Hits	146	Target Neighborhood Hits	155	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NHERF_MOUSE
NC score	0.234907 (rank : 98)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	146	Target Neighborhood Hits	195	Shared Neighborhood Hits	98
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
NC score	0.232537 (rank : 99)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	146	Target Neighborhood Hits	197	Shared Neighborhood Hits	101
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

AXN2_MOUSE
NC score	0.229242 (rank : 100)	θ value	0.00020696 (rank : 38)
Query Neighborhood Hits	146	Target Neighborhood Hits	116	Shared Neighborhood Hits	15
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

APBA1_HUMAN
NC score	0.228705 (rank : 101)	θ value	0.47712 (rank : 94)
Query Neighborhood Hits	146	Target Neighborhood Hits	325	Shared Neighborhood Hits	104
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

MPP5_HUMAN
NC score	0.227711 (rank : 102)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	146	Target Neighborhood Hits	231	Shared Neighborhood Hits	102
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.227100 (rank : 103)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	146	Target Neighborhood Hits	226	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

APBA2_MOUSE
NC score	0.225866 (rank : 104)	θ value	0.125558 (rank : 83)
Query Neighborhood Hits	146	Target Neighborhood Hits	219	Shared Neighborhood Hits	101
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

NHRF2_MOUSE
NC score	0.225556 (rank : 105)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	146	Target Neighborhood Hits	194	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

APBA2_HUMAN
NC score	0.225294 (rank : 106)	θ value	0.125558 (rank : 82)
Query Neighborhood Hits	146	Target Neighborhood Hits	220	Shared Neighborhood Hits	101
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

RPGF2_HUMAN
NC score	0.224790 (rank : 107)	θ value	0.0736092 (rank : 79)
Query Neighborhood Hits	146	Target Neighborhood Hits	242	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

NHERF_HUMAN
NC score	0.222574 (rank : 108)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	146	Target Neighborhood Hits	190	Shared Neighborhood Hits	99
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

AXN2_HUMAN
NC score	0.220924 (rank : 109)	θ value	0.000602161 (rank : 44)
Query Neighborhood Hits	146	Target Neighborhood Hits	102	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2T1, Q9H3M6, Q9UH84	Gene names	AXIN2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

PDZD3_HUMAN
NC score	0.217051 (rank : 110)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	146	Target Neighborhood Hits	180	Shared Neighborhood Hits	98
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PICK1_MOUSE
NC score	0.215499 (rank : 111)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	146	Target Neighborhood Hits	131	Shared Neighborhood Hits	93
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

EM55_HUMAN
NC score	0.214393 (rank : 112)	θ value	0.62314 (rank : 101)
Query Neighborhood Hits	146	Target Neighborhood Hits	228	Shared Neighborhood Hits	94
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
NC score	0.213903 (rank : 113)	θ value	0.62314 (rank : 102)
Query Neighborhood Hits	146	Target Neighborhood Hits	221	Shared Neighborhood Hits	93
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

AXN1_HUMAN
NC score	0.213538 (rank : 114)	θ value	0.000602161 (rank : 43)
Query Neighborhood Hits	146	Target Neighborhood Hits	99	Shared Neighborhood Hits	16
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

PICK1_HUMAN
NC score	0.212951 (rank : 115)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	146	Target Neighborhood Hits	132	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PDZD3_MOUSE
NC score	0.201517 (rank : 116)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	146	Target Neighborhood Hits	171	Shared Neighborhood Hits	96
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

AXN1_MOUSE
NC score	0.197148 (rank : 117)	θ value	0.00390308 (rank : 53)
Query Neighborhood Hits	146	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	O35625	Gene names	Axin1, Axin, Fu
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (Fused protein).

APBA3_HUMAN
NC score	0.193268 (rank : 118)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	146	Target Neighborhood Hits	201	Shared Neighborhood Hits	93
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA3_MOUSE
NC score	0.171836 (rank : 119)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	146	Target Neighborhood Hits	174	Shared Neighborhood Hits	90
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

LRRC7_HUMAN
NC score	0.167293 (rank : 120)	θ value	0.125558 (rank : 86)
Query Neighborhood Hits	146	Target Neighborhood Hits	423	Shared Neighborhood Hits	87
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.166747 (rank : 121)	θ value	0.125558 (rank : 87)
Query Neighborhood Hits	146	Target Neighborhood Hits	416	Shared Neighborhood Hits	87
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

MPP6_MOUSE
NC score	0.166207 (rank : 122)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	146	Target Neighborhood Hits	187	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MPP2_MOUSE
NC score	0.165690 (rank : 123)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	146	Target Neighborhood Hits	189	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP6_HUMAN
NC score	0.164478 (rank : 124)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	146	Target Neighborhood Hits	180	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

PAR6B_MOUSE
NC score	0.164130 (rank : 125)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	146	Target Neighborhood Hits	128	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_HUMAN
NC score	0.163902 (rank : 126)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	146	Target Neighborhood Hits	126	Shared Neighborhood Hits	92
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_MOUSE
NC score	0.163446 (rank : 127)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	146	Target Neighborhood Hits	121	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

MPP2_HUMAN
NC score	0.163021 (rank : 128)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	146	Target Neighborhood Hits	173	Shared Neighborhood Hits	69
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

PAR6G_HUMAN
NC score	0.162975 (rank : 129)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	146	Target Neighborhood Hits	159	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

LAP2_HUMAN
NC score	0.161697 (rank : 130)	θ value	0.125558 (rank : 84)
Query Neighborhood Hits	146	Target Neighborhood Hits	499	Shared Neighborhood Hits	86
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
NC score	0.156041 (rank : 131)	θ value	0.125558 (rank : 85)
Query Neighborhood Hits	146	Target Neighborhood Hits	482	Shared Neighborhood Hits	83
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PAR6A_HUMAN
NC score	0.155027 (rank : 132)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	146	Target Neighborhood Hits	119	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

SDCB1_HUMAN
NC score	0.154831 (rank : 133)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	146	Target Neighborhood Hits	150	Shared Neighborhood Hits	94
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

PAR6A_MOUSE
NC score	0.154636 (rank : 134)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	146	Target Neighborhood Hits	115	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PDZD6_HUMAN
NC score	0.152994 (rank : 135)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	146	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

SDCB1_MOUSE
NC score	0.152730 (rank : 136)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	146	Target Neighborhood Hits	144	Shared Neighborhood Hits	88
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

RGS12_HUMAN
NC score	0.144075 (rank : 137)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	146	Target Neighborhood Hits	333	Shared Neighborhood Hits	90
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

PDLI2_HUMAN
NC score	0.140060 (rank : 138)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	146	Target Neighborhood Hits	245	Shared Neighborhood Hits	79
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

RIMS1_HUMAN
NC score	0.135093 (rank : 139)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	146	Target Neighborhood Hits	437	Shared Neighborhood Hits	88
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

DEPD5_HUMAN
NC score	0.134759 (rank : 140)	θ value	0.0330416 (rank : 67)
Query Neighborhood Hits	146	Target Neighborhood Hits	40	Shared Neighborhood Hits	13
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

KGUA_MOUSE
NC score	0.132386 (rank : 141)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	146	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_HUMAN
NC score	0.131415 (rank : 142)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	146	Target Neighborhood Hits	41	Shared Neighborhood Hits	23
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

ARHGB_HUMAN
NC score	0.130412 (rank : 143)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	146	Target Neighborhood Hits	375	Shared Neighborhood Hits	100
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SDCB2_MOUSE
NC score	0.127601 (rank : 144)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	146	Target Neighborhood Hits	118	Shared Neighborhood Hits	79
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

GRASP_HUMAN
NC score	0.126369 (rank : 145)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	146	Target Neighborhood Hits	147	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

RGS11_HUMAN
NC score	0.125051 (rank : 146)	θ value	0.000602161 (rank : 46)
Query Neighborhood Hits	146	Target Neighborhood Hits	68	Shared Neighborhood Hits	17
SwissProt Accessions	O94810, O75883	Gene names	RGS11
Domain Architecture
Description	Regulator of G-protein signaling 11 (RGS11).

GRASP_MOUSE
NC score	0.122756 (rank : 147)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	146	Target Neighborhood Hits	131	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

SDCB2_HUMAN
NC score	0.122074 (rank : 148)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	146	Target Neighborhood Hits	121	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PDLI2_MOUSE
NC score	0.116647 (rank : 149)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	146	Target Neighborhood Hits	220	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

RHPN1_MOUSE
NC score	0.115195 (rank : 150)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	146	Target Neighborhood Hits	154	Shared Neighborhood Hits	73
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PSCBP_MOUSE
NC score	0.114682 (rank : 151)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	146	Target Neighborhood Hits	118	Shared Neighborhood Hits	69
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PCLO_MOUSE
NC score	0.113996 (rank : 152)	θ value	0.47712 (rank : 98)
Query Neighborhood Hits	146	Target Neighborhood Hits	2275	Shared Neighborhood Hits	109
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ARHGC_MOUSE
NC score	0.111041 (rank : 153)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	146	Target Neighborhood Hits	344	Shared Neighborhood Hits	92
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.110369 (rank : 154)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	146	Target Neighborhood Hits	351	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PSCBP_HUMAN
NC score	0.103496 (rank : 155)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	146	Target Neighborhood Hits	123	Shared Neighborhood Hits	70
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

RHPN1_HUMAN
NC score	0.103104 (rank : 156)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	146	Target Neighborhood Hits	158	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RIMS2_HUMAN
NC score	0.102228 (rank : 157)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	146	Target Neighborhood Hits	342	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

SYP2L_HUMAN
NC score	0.102157 (rank : 158)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	146	Target Neighborhood Hits	400	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

RIMS2_MOUSE
NC score	0.099951 (rank : 159)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	146	Target Neighborhood Hits	376	Shared Neighborhood Hits	80
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RGS9_HUMAN
NC score	0.097000 (rank : 160)	θ value	0.47712 (rank : 100)
Query Neighborhood Hits	146	Target Neighborhood Hits	64	Shared Neighborhood Hits	17
SwissProt Accessions	O75916, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33	Gene names	RGS9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

GIPC1_MOUSE
NC score	0.096904 (rank : 161)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	146	Target Neighborhood Hits	92	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

APXL_HUMAN
NC score	0.095696 (rank : 162)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	146	Target Neighborhood Hits	553	Shared Neighborhood Hits	63
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

RGS9_MOUSE
NC score	0.095244 (rank : 163)	θ value	0.365318 (rank : 93)
Query Neighborhood Hits	146	Target Neighborhood Hits	65	Shared Neighborhood Hits	16
SwissProt Accessions	O54828, Q9Z0S0	Gene names	Rgs9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

SHAN2_HUMAN
NC score	0.091661 (rank : 164)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	146	Target Neighborhood Hits	346	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

GIPC1_HUMAN
NC score	0.090778 (rank : 165)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	146	Target Neighborhood Hits	91	Shared Neighborhood Hits	67
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

SYNP2_MOUSE
NC score	0.087690 (rank : 166)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	146	Target Neighborhood Hits	252	Shared Neighborhood Hits	69
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SHAN2_MOUSE
NC score	0.080730 (rank : 167)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	146	Target Neighborhood Hits	446	Shared Neighborhood Hits	73
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

DEPD5_MOUSE
NC score	0.080579 (rank : 168)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	146	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

PDLI3_HUMAN
NC score	0.076366 (rank : 169)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	146	Target Neighborhood Hits	199	Shared Neighborhood Hits	67
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

GIPC2_HUMAN
NC score	0.072793 (rank : 170)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	146	Target Neighborhood Hits	93	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

PDLI4_MOUSE
NC score	0.072208 (rank : 171)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	146	Target Neighborhood Hits	233	Shared Neighborhood Hits	64
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_HUMAN
NC score	0.071062 (rank : 172)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	146	Target Neighborhood Hits	245	Shared Neighborhood Hits	63
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

SYP2L_MOUSE
NC score	0.066426 (rank : 173)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	146	Target Neighborhood Hits	289	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PDLI3_MOUSE
NC score	0.066314 (rank : 174)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	146	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

CSKP_HUMAN
NC score	0.064510 (rank : 175)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	146	Target Neighborhood Hits	1022	Shared Neighborhood Hits	90
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

PDLI1_MOUSE
NC score	0.063608 (rank : 176)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	146	Target Neighborhood Hits	213	Shared Neighborhood Hits	55
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_HUMAN
NC score	0.063229 (rank : 177)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	146	Target Neighborhood Hits	242	Shared Neighborhood Hits	56
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PTN4_HUMAN
NC score	0.062737 (rank : 178)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	146	Target Neighborhood Hits	303	Shared Neighborhood Hits	80
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

CSKP_MOUSE
NC score	0.062311 (rank : 179)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	146	Target Neighborhood Hits	1027	Shared Neighborhood Hits	91
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

SYNP2_HUMAN
NC score	0.061242 (rank : 180)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	146	Target Neighborhood Hits	323	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SHAN1_HUMAN
NC score	0.060005 (rank : 181)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	146	Target Neighborhood Hits	1041	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

RPGF4_MOUSE
NC score	0.059708 (rank : 182)	θ value	0.813845 (rank : 106)
Query Neighborhood Hits	146	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

PDLI5_MOUSE
NC score	0.059474 (rank : 183)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	146	Target Neighborhood Hits	287	Shared Neighborhood Hits	68
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_HUMAN
NC score	0.059248 (rank : 184)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	146	Target Neighborhood Hits	322	Shared Neighborhood Hits	68
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PREX1_HUMAN
NC score	0.058149 (rank : 185)	θ value	0.47712 (rank : 99)
Query Neighborhood Hits	146	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

LDB3_MOUSE
NC score	0.057242 (rank : 186)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	146	Target Neighborhood Hits	510	Shared Neighborhood Hits	63
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

PTN3_HUMAN
NC score	0.056826 (rank : 187)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	146	Target Neighborhood Hits	258	Shared Neighborhood Hits	74
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

LDB3_HUMAN
NC score	0.056204 (rank : 188)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	146	Target Neighborhood Hits	497	Shared Neighborhood Hits	64
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

RNF41_MOUSE
NC score	0.055091 (rank : 189)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	146	Target Neighborhood Hits	224	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_HUMAN
NC score	0.054971 (rank : 190)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	146	Target Neighborhood Hits	226	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

PRAX_MOUSE
NC score	0.052932 (rank : 191)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	146	Target Neighborhood Hits	199	Shared Neighborhood Hits	35
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

RPGF4_HUMAN
NC score	0.051145 (rank : 192)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	146	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF5_MOUSE
NC score	0.050531 (rank : 193)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	146	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

PLEK_MOUSE
NC score	0.042027 (rank : 194)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	146	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

MY18A_MOUSE
NC score	0.038561 (rank : 195)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	146	Target Neighborhood Hits	1989	Shared Neighborhood Hits	94
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_HUMAN
NC score	0.033707 (rank : 196)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	146	Target Neighborhood Hits	1929	Shared Neighborhood Hits	93
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

FYV1_HUMAN
NC score	0.029779 (rank : 197)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	146	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

TCGAP_HUMAN
NC score	0.029120 (rank : 198)	θ value	0.62314 (rank : 103)
Query Neighborhood Hits	146	Target Neighborhood Hits	872	Shared Neighborhood Hits	17
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

JARD2_HUMAN
NC score	0.023502 (rank : 199)	θ value	0.813845 (rank : 104)
Query Neighborhood Hits	146	Target Neighborhood Hits	119	Shared Neighborhood Hits	5
SwissProt Accessions	Q92833, Q5U5L5	Gene names	JARID2, JMJ
Domain Architecture
Description	Jumonji protein (Jumonji/ARID domain-containing protein 2).

FRS3_MOUSE
NC score	0.019304 (rank : 200)	θ value	0.47712 (rank : 95)
Query Neighborhood Hits	146	Target Neighborhood Hits	168	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

TEX15_HUMAN
NC score	0.017620 (rank : 201)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	146	Target Neighborhood Hits	174	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BXT5	Gene names	TEX15
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 15 protein.

TAU_HUMAN
NC score	0.015479 (rank : 202)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	146	Target Neighborhood Hits	448	Shared Neighborhood Hits	10
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TR150_HUMAN
NC score	0.014110 (rank : 203)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	146	Target Neighborhood Hits	313	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

SSBP4_HUMAN
NC score	0.012751 (rank : 204)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	146	Target Neighborhood Hits	753	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

BCAR1_HUMAN
NC score	0.008029 (rank : 205)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	146	Target Neighborhood Hits	554	Shared Neighborhood Hits	13
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SYNG_MOUSE
NC score	0.007467 (rank : 206)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	146	Target Neighborhood Hits	206	Shared Neighborhood Hits	6
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

SOCS6_MOUSE
NC score	0.004870 (rank : 207)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	146	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

LYST_HUMAN
NC score	0.004773 (rank : 208)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	146	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

ANK3_HUMAN
NC score	-0.000916 (rank : 209)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	146	Target Neighborhood Hits	853	Shared Neighborhood Hits	7
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

MRCKB_MOUSE
NC score	-0.001282 (rank : 210)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	146	Target Neighborhood Hits	2180	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

ZN592_MOUSE
NC score	-0.001491 (rank : 211)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	146	Target Neighborhood Hits	768	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BHZ4, Q80XM1	Gene names	Znf592, Kiaa0211, Zfp592
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592 (Zfp-592).

MRCKB_HUMAN
NC score	-0.001618 (rank : 212)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	146	Target Neighborhood Hits	2239	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

ZBTB5_HUMAN
NC score	-0.002747 (rank : 213)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	146	Target Neighborhood Hits	811	Shared Neighborhood Hits	4
SwissProt Accessions	O15062	Gene names	ZBTB5, KIAA0354
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 5.