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Network neighborhood for query Sequence : AXN1_HUMAN

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AXN1_HUMAN
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AXN1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	99	Target Neighborhood Hits	99	Shared Neighborhood Hits	99
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

AXN1_MOUSE
θ value	0 (rank : 2)	NC score	0.992127 (rank : 2)
Query Neighborhood Hits	99	Target Neighborhood Hits	89	Shared Neighborhood Hits	63
SwissProt Accessions	O35625	Gene names	Axin1, Axin, Fu
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (Fused protein).

AXN2_HUMAN
θ value	8.33966e-147 (rank : 3)	NC score	0.953621 (rank : 3)
Query Neighborhood Hits	99	Target Neighborhood Hits	102	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2T1, Q9H3M6, Q9UH84	Gene names	AXIN2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

AXN2_MOUSE
θ value	2.77624e-142 (rank : 4)	NC score	0.948670 (rank : 4)
Query Neighborhood Hits	99	Target Neighborhood Hits	116	Shared Neighborhood Hits	48
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

RGS3_HUMAN
θ value	9.90251e-15 (rank : 5)	NC score	0.504799 (rank : 35)
Query Neighborhood Hits	99	Target Neighborhood Hits	1375	Shared Neighborhood Hits	60
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RGS10_HUMAN
θ value	1.68911e-14 (rank : 6)	NC score	0.712747 (rank : 5)
Query Neighborhood Hits	99	Target Neighborhood Hits	57	Shared Neighborhood Hits	46
SwissProt Accessions	O43665	Gene names	RGS10
Domain Architecture
Description	Regulator of G-protein signaling 10 (RGS10).

RGS3_MOUSE
θ value	4.91457e-14 (rank : 7)	NC score	0.444140 (rank : 40)
Query Neighborhood Hits	99	Target Neighborhood Hits	1621	Shared Neighborhood Hits	56
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RGS10_MOUSE
θ value	1.42992e-13 (rank : 8)	NC score	0.705571 (rank : 6)
Query Neighborhood Hits	99	Target Neighborhood Hits	57	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CQE5, Q9D3L2	Gene names	Rgs10
Domain Architecture
Description	Regulator of G-protein signaling 10 (RGS10).

RGS18_MOUSE
θ value	1.42992e-13 (rank : 9)	NC score	0.697968 (rank : 7)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	42
SwissProt Accessions	Q99PG4	Gene names	Rgs18
Domain Architecture
Description	Regulator of G-protein signaling 18 (RGS18).

RGS5_HUMAN
θ value	1.86753e-13 (rank : 10)	NC score	0.692757 (rank : 9)
Query Neighborhood Hits	99	Target Neighborhood Hits	52	Shared Neighborhood Hits	45
SwissProt Accessions	O15539	Gene names	RGS5
Domain Architecture
Description	Regulator of G-protein signaling 5 (RGS5).

RGS18_HUMAN
θ value	3.18553e-13 (rank : 11)	NC score	0.697833 (rank : 8)
Query Neighborhood Hits	99	Target Neighborhood Hits	44	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NS28	Gene names	RGS18, RGS13
Domain Architecture
Description	Regulator of G-protein signaling 18 (RGS18).

RGS1_HUMAN
θ value	4.16044e-13 (rank : 12)	NC score	0.690311 (rank : 10)
Query Neighborhood Hits	99	Target Neighborhood Hits	50	Shared Neighborhood Hits	45
SwissProt Accessions	Q08116, Q07918, Q9H1W2	Gene names	RGS1, 1R20, BL34
Domain Architecture
Description	Regulator of G-protein signaling 1 (RGS1) (Early response protein 1R20) (B-cell activation protein BL34).

RGS5_MOUSE
θ value	1.2105e-12 (rank : 13)	NC score	0.685938 (rank : 13)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	44
SwissProt Accessions	O08850, Q543B1, Q9D0Z2	Gene names	Rgs5
Domain Architecture
Description	Regulator of G-protein signaling 5 (RGS5).

RGS8_HUMAN
θ value	1.58096e-12 (rank : 14)	NC score	0.687206 (rank : 12)
Query Neighborhood Hits	99	Target Neighborhood Hits	45	Shared Neighborhood Hits	43
SwissProt Accessions	P57771, Q3SYD2	Gene names	RGS8
Domain Architecture
Description	Regulator of G-protein signaling 8 (RGS8).

RGS8_MOUSE
θ value	1.58096e-12 (rank : 15)	NC score	0.688579 (rank : 11)
Query Neighborhood Hits	99	Target Neighborhood Hits	46	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BXT1	Gene names	Rgs8
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 8 (RGS8).

RGS17_MOUSE
θ value	3.52202e-12 (rank : 16)	NC score	0.663019 (rank : 23)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZB0, Q543T9	Gene names	Rgs17, Rgsz2
Domain Architecture
Description	Regulator of G-protein signaling 17 (RGS17) (Regulator of Gz-selective protein signaling 2).

RGS4_MOUSE
θ value	1.33837e-11 (rank : 17)	NC score	0.683634 (rank : 16)
Query Neighborhood Hits	99	Target Neighborhood Hits	46	Shared Neighborhood Hits	43
SwissProt Accessions	O08899, Q99L30	Gene names	Rgs4
Domain Architecture
Description	Regulator of G-protein signaling 4 (RGS4).

RGS2_MOUSE
θ value	1.74796e-11 (rank : 18)	NC score	0.682622 (rank : 17)
Query Neighborhood Hits	99	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	O08849, Q544S7, Q91WX1, Q9JL24	Gene names	Rgs2
Domain Architecture
Description	Regulator of G-protein signaling 2 (RGS2).

RGS4_HUMAN
θ value	1.74796e-11 (rank : 19)	NC score	0.682085 (rank : 18)
Query Neighborhood Hits	99	Target Neighborhood Hits	48	Shared Neighborhood Hits	43
SwissProt Accessions	P49798	Gene names	RGS4
Domain Architecture
Description	Regulator of G-protein signaling 4 (RGS4) (RGP4).

RGS1_MOUSE
θ value	2.28291e-11 (rank : 20)	NC score	0.684743 (rank : 15)
Query Neighborhood Hits	99	Target Neighborhood Hits	60	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JL25, Q3TBD1, Q3TC18, Q3TD56	Gene names	Rgs1
Domain Architecture
Description	Regulator of G-protein signaling 1 (RGS1).

RGS2_HUMAN
θ value	2.28291e-11 (rank : 21)	NC score	0.685857 (rank : 14)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	44
SwissProt Accessions	P41220	Gene names	RGS2, G0S8
Domain Architecture
Description	Regulator of G-protein signaling 2 (RGS2) (G0/G1 switch regulatory protein 8).

RGS16_MOUSE
θ value	3.89403e-11 (rank : 22)	NC score	0.676076 (rank : 19)
Query Neighborhood Hits	99	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	P97428, O09091, P97420, Q80V16	Gene names	Rgs16, Rgsr
Domain Architecture
Description	Regulator of G-protein signaling 16 (RGS16) (Retinally abundant regulator of G-protein signaling) (RGS-R) (A28-RGS14P).

RGS20_MOUSE
θ value	2.52405e-10 (rank : 23)	NC score	0.658041 (rank : 24)
Query Neighborhood Hits	99	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZB1, Q3TY63, Q9CUV8, Q9QZB2	Gene names	Rgs20, Rgsz1
Domain Architecture
Description	Regulator of G-protein signaling 20 (RGS20) (Regulator of G-protein signaling Z1).

RGS13_MOUSE
θ value	3.29651e-10 (rank : 24)	NC score	0.675775 (rank : 20)
Query Neighborhood Hits	99	Target Neighborhood Hits	45	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K443	Gene names	Rgs13
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 13 (RGS13).

RGS16_HUMAN
θ value	5.62301e-10 (rank : 25)	NC score	0.670429 (rank : 22)
Query Neighborhood Hits	99	Target Neighborhood Hits	45	Shared Neighborhood Hits	42
SwissProt Accessions	O15492, Q99701	Gene names	RGS16, RGSR
Domain Architecture
Description	Regulator of G-protein signaling 16 (RGS16) (Retinally abundant regulator of G-protein signaling) (RGS-R) (A28-RGS14P).

RGS14_HUMAN
θ value	7.34386e-10 (rank : 26)	NC score	0.621802 (rank : 30)
Query Neighborhood Hits	99	Target Neighborhood Hits	77	Shared Neighborhood Hits	42
SwissProt Accessions	O43566, O43565, Q8TD62	Gene names	RGS14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14).

RGS17_HUMAN
θ value	7.34386e-10 (rank : 27)	NC score	0.652308 (rank : 27)
Query Neighborhood Hits	99	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UGC6, Q5TF49, Q8TD61, Q9UJS8	Gene names	RGS17
Domain Architecture
Description	Regulator of G-protein signaling 17 (RGS17).

RGS20_HUMAN
θ value	9.59137e-10 (rank : 28)	NC score	0.646598 (rank : 28)
Query Neighborhood Hits	99	Target Neighborhood Hits	55	Shared Neighborhood Hits	42
SwissProt Accessions	O76081, Q96BG9	Gene names	RGS20, RGSZ1, ZGAP1
Domain Architecture
Description	Regulator of G-protein signaling 20 (RGS20) (Regulator of Gz-selective protein signaling 1) (Gz-selective GTPase-activating protein) (G(z)GAP).

RGS19_HUMAN
θ value	1.63604e-09 (rank : 29)	NC score	0.654391 (rank : 26)
Query Neighborhood Hits	99	Target Neighborhood Hits	45	Shared Neighborhood Hits	42
SwissProt Accessions	P49795, Q53XN0, Q8TD60	Gene names	RGS19, GAIP, GNAI3IP
Domain Architecture
Description	Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP protein).

RGS14_MOUSE
θ value	2.13673e-09 (rank : 30)	NC score	0.629383 (rank : 29)
Query Neighborhood Hits	99	Target Neighborhood Hits	55	Shared Neighborhood Hits	40
SwissProt Accessions	P97492, Q9DCD1	Gene names	Rgs14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2-interacting protein).

RGS19_MOUSE
θ value	4.76016e-09 (rank : 31)	NC score	0.654540 (rank : 25)
Query Neighborhood Hits	99	Target Neighborhood Hits	46	Shared Neighborhood Hits	42
SwissProt Accessions	Q9CX84, Q99L50	Gene names	Rgs19
Domain Architecture
Description	Regulator of G-protein signaling 19 (RGS19).

RGS13_HUMAN
θ value	6.21693e-09 (rank : 32)	NC score	0.673757 (rank : 21)
Query Neighborhood Hits	99	Target Neighborhood Hits	48	Shared Neighborhood Hits	45
SwissProt Accessions	O14921, Q6PGR2, Q8TD63, Q9BX45	Gene names	RGS13
Domain Architecture
Description	Regulator of G-protein signaling 13 (RGS13).

RGS12_HUMAN
θ value	6.43352e-06 (rank : 33)	NC score	0.526789 (rank : 34)
Query Neighborhood Hits	99	Target Neighborhood Hits	333	Shared Neighborhood Hits	53
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

DVL2_HUMAN
θ value	1.43324e-05 (rank : 34)	NC score	0.230057 (rank : 44)
Query Neighborhood Hits	99	Target Neighborhood Hits	223	Shared Neighborhood Hits	18
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	1.43324e-05 (rank : 35)	NC score	0.230702 (rank : 43)
Query Neighborhood Hits	99	Target Neighborhood Hits	233	Shared Neighborhood Hits	21
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
θ value	1.87187e-05 (rank : 36)	NC score	0.237050 (rank : 42)
Query Neighborhood Hits	99	Target Neighborhood Hits	194	Shared Neighborhood Hits	18
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	1.87187e-05 (rank : 37)	NC score	0.237240 (rank : 41)
Query Neighborhood Hits	99	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

RGS11_HUMAN
θ value	5.44631e-05 (rank : 38)	NC score	0.553728 (rank : 31)
Query Neighborhood Hits	99	Target Neighborhood Hits	68	Shared Neighborhood Hits	50
SwissProt Accessions	O94810, O75883	Gene names	RGS11
Domain Architecture
Description	Regulator of G-protein signaling 11 (RGS11).

RGS9_MOUSE
θ value	7.1131e-05 (rank : 39)	NC score	0.530727 (rank : 32)
Query Neighborhood Hits	99	Target Neighborhood Hits	65	Shared Neighborhood Hits	48
SwissProt Accessions	O54828, Q9Z0S0	Gene names	Rgs9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

RGS9_HUMAN
θ value	0.000158464 (rank : 40)	NC score	0.529709 (rank : 33)
Query Neighborhood Hits	99	Target Neighborhood Hits	64	Shared Neighborhood Hits	48
SwissProt Accessions	O75916, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33	Gene names	RGS9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

DVL1L_HUMAN
θ value	0.000602161 (rank : 41)	NC score	0.213538 (rank : 47)
Query Neighborhood Hits	99	Target Neighborhood Hits	146	Shared Neighborhood Hits	16
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	0.000602161 (rank : 42)	NC score	0.211332 (rank : 49)
Query Neighborhood Hits	99	Target Neighborhood Hits	158	Shared Neighborhood Hits	17
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	0.000602161 (rank : 43)	NC score	0.211388 (rank : 48)
Query Neighborhood Hits	99	Target Neighborhood Hits	146	Shared Neighborhood Hits	16
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

SNX14_HUMAN
θ value	0.00175202 (rank : 44)	NC score	0.152386 (rank : 53)
Query Neighborhood Hits	99	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

SNX14_MOUSE
θ value	0.00175202 (rank : 45)	NC score	0.152639 (rank : 52)
Query Neighborhood Hits	99	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

RGS7_HUMAN
θ value	0.00665767 (rank : 46)	NC score	0.499228 (rank : 36)
Query Neighborhood Hits	99	Target Neighborhood Hits	82	Shared Neighborhood Hits	48
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

ARBK1_HUMAN
θ value	0.0113563 (rank : 47)	NC score	0.023388 (rank : 69)
Query Neighborhood Hits	99	Target Neighborhood Hits	859	Shared Neighborhood Hits	18
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	0.0113563 (rank : 48)	NC score	0.020146 (rank : 71)
Query Neighborhood Hits	99	Target Neighborhood Hits	849	Shared Neighborhood Hits	14
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

CT151_HUMAN
θ value	0.0193708 (rank : 49)	NC score	0.067573 (rank : 55)
Query Neighborhood Hits	99	Target Neighborhood Hits	382	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

BAZ1B_HUMAN
θ value	0.0330416 (rank : 50)	NC score	0.041399 (rank : 59)
Query Neighborhood Hits	99	Target Neighborhood Hits	701	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

RGS7_MOUSE
θ value	0.0431538 (rank : 51)	NC score	0.491638 (rank : 37)
Query Neighborhood Hits	99	Target Neighborhood Hits	79	Shared Neighborhood Hits	49
SwissProt Accessions	O54829	Gene names	Rgs7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

MARCS_MOUSE
θ value	0.0961366 (rank : 52)	NC score	0.054881 (rank : 56)
Query Neighborhood Hits	99	Target Neighborhood Hits	227	Shared Neighborhood Hits	11
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

SNX13_HUMAN
θ value	0.0961366 (rank : 53)	NC score	0.226296 (rank : 45)
Query Neighborhood Hits	99	Target Neighborhood Hits	84	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y5W8, O94821, Q8WVZ2, Q8WXH8	Gene names	SNX13, KIAA0713
Domain Architecture
Description	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1).

SNX13_MOUSE
θ value	0.0961366 (rank : 54)	NC score	0.226263 (rank : 46)
Query Neighborhood Hits	99	Target Neighborhood Hits	86	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PHS6	Gene names	Snx13
Domain Architecture	No domain graphic available
Description	Sorting nexin-13.

CD2_HUMAN
θ value	0.125558 (rank : 55)	NC score	0.045414 (rank : 57)
Query Neighborhood Hits	99	Target Neighborhood Hits	504	Shared Neighborhood Hits	12
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

ES8L1_HUMAN
θ value	0.21417 (rank : 56)	NC score	0.030856 (rank : 64)
Query Neighborhood Hits	99	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

RGS6_MOUSE
θ value	0.279714 (rank : 57)	NC score	0.478737 (rank : 38)
Query Neighborhood Hits	99	Target Neighborhood Hits	71	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

EP300_HUMAN
θ value	0.62314 (rank : 58)	NC score	0.036376 (rank : 60)
Query Neighborhood Hits	99	Target Neighborhood Hits	821	Shared Neighborhood Hits	14
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

ES8L1_MOUSE
θ value	0.62314 (rank : 59)	NC score	0.027935 (rank : 67)
Query Neighborhood Hits	99	Target Neighborhood Hits	143	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

CDSN_MOUSE
θ value	0.813845 (rank : 60)	NC score	0.031287 (rank : 63)
Query Neighborhood Hits	99	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

PDZD2_HUMAN
θ value	0.813845 (rank : 61)	NC score	0.045217 (rank : 58)
Query Neighborhood Hits	99	Target Neighborhood Hits	772	Shared Neighborhood Hits	29
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SRRM2_MOUSE
θ value	1.06291 (rank : 62)	NC score	0.022364 (rank : 70)
Query Neighborhood Hits	99	Target Neighborhood Hits	1470	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ZN333_HUMAN
θ value	1.06291 (rank : 63)	NC score	-0.002316 (rank : 100)
Query Neighborhood Hits	99	Target Neighborhood Hits	750	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JL9, Q8TDL0	Gene names	ZNF333, KIAA1806
Domain Architecture
Description	Zinc finger protein 333.

ARBK2_HUMAN
θ value	1.38821 (rank : 64)	NC score	0.019144 (rank : 72)
Query Neighborhood Hits	99	Target Neighborhood Hits	849	Shared Neighborhood Hits	17
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

RGS6_HUMAN
θ value	1.81305 (rank : 65)	NC score	0.448389 (rank : 39)
Query Neighborhood Hits	99	Target Neighborhood Hits	80	Shared Neighborhood Hits	44
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

CAC1C_HUMAN
θ value	2.36792 (rank : 66)	NC score	0.007143 (rank : 85)
Query Neighborhood Hits	99	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

SRCA_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.025487 (rank : 68)
Query Neighborhood Hits	99	Target Neighborhood Hits	380	Shared Neighborhood Hits	13
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

GATA3_MOUSE
θ value	3.0926 (rank : 68)	NC score	0.009830 (rank : 81)
Query Neighborhood Hits	99	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	P23772	Gene names	Gata3, Gata-3
Domain Architecture
Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3).

OGFR_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.017771 (rank : 75)
Query Neighborhood Hits	99	Target Neighborhood Hits	1582	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PK3C3_HUMAN
θ value	3.0926 (rank : 70)	NC score	0.018624 (rank : 74)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.018634 (rank : 73)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

CBP_HUMAN
θ value	4.03905 (rank : 72)	NC score	0.031655 (rank : 62)
Query Neighborhood Hits	99	Target Neighborhood Hits	941	Shared Neighborhood Hits	16
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_MOUSE
θ value	4.03905 (rank : 73)	NC score	0.028563 (rank : 65)
Query Neighborhood Hits	99	Target Neighborhood Hits	1051	Shared Neighborhood Hits	15
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

PPRB_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.015127 (rank : 76)
Query Neighborhood Hits	99	Target Neighborhood Hits	311	Shared Neighborhood Hits	11
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

RGP2_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.011589 (rank : 78)
Query Neighborhood Hits	99	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

SPAG1_MOUSE
θ value	4.03905 (rank : 76)	NC score	0.013258 (rank : 77)
Query Neighborhood Hits	99	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	Q80ZX8, Q8CCK7, Q9QZJ3, Q9QZJ4	Gene names	Spag1, Tpis
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS).

FOXJ3_HUMAN
θ value	5.27518 (rank : 77)	NC score	0.006290 (rank : 89)
Query Neighborhood Hits	99	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

K1949_HUMAN
θ value	5.27518 (rank : 78)	NC score	0.035163 (rank : 61)
Query Neighborhood Hits	99	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q6NYC8, Q68CK8, Q6ZUJ6, Q8NDQ4, Q8TF52, Q9BRL9	Gene names	KIAA1949
Domain Architecture	No domain graphic available
Description	Protein KIAA1949.

MSX2_MOUSE
θ value	5.27518 (rank : 79)	NC score	0.000802 (rank : 95)
Query Neighborhood Hits	99	Target Neighborhood Hits	345	Shared Neighborhood Hits	2
SwissProt Accessions	Q03358, Q63856	Gene names	Msx2, Hox-8.1, Msx-2
Domain Architecture
Description	Homeobox protein MSX-2 (Hox-8.1).

SNX25_HUMAN
θ value	5.27518 (rank : 80)	NC score	0.115270 (rank : 54)
Query Neighborhood Hits	99	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H3E2	Gene names	SNX25
Domain Architecture
Description	Sorting nexin-25.

SVIL_MOUSE
θ value	5.27518 (rank : 81)	NC score	0.010507 (rank : 79)
Query Neighborhood Hits	99	Target Neighborhood Hits	439	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

ZHX2_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.006922 (rank : 86)
Query Neighborhood Hits	99	Target Neighborhood Hits	347	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6X8	Gene names	ZHX2, AFR1, KIAA0854, RAF
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

ZN358_HUMAN
θ value	5.27518 (rank : 83)	NC score	-0.001066 (rank : 97)
Query Neighborhood Hits	99	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

DDX49_HUMAN
θ value	6.88961 (rank : 84)	NC score	0.006809 (rank : 87)
Query Neighborhood Hits	99	Target Neighborhood Hits	223	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

FOXJ3_MOUSE
θ value	6.88961 (rank : 85)	NC score	0.005839 (rank : 90)
Query Neighborhood Hits	99	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUR3, Q3UTD8	Gene names	Foxj3, Kiaa1041
Domain Architecture
Description	Forkhead box protein J3.

K1949_MOUSE
θ value	6.88961 (rank : 86)	NC score	0.028397 (rank : 66)
Query Neighborhood Hits	99	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

LRP1_HUMAN
θ value	6.88961 (rank : 87)	NC score	-0.000299 (rank : 96)
Query Neighborhood Hits	99	Target Neighborhood Hits	617	Shared Neighborhood Hits	2
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

MAST4_HUMAN
θ value	6.88961 (rank : 88)	NC score	0.004278 (rank : 92)
Query Neighborhood Hits	99	Target Neighborhood Hits	1804	Shared Neighborhood Hits	25
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MRP6_MOUSE
θ value	6.88961 (rank : 89)	NC score	0.002358 (rank : 94)
Query Neighborhood Hits	99	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1S7, Q80YB6	Gene names	Abcc6, Mrp6
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 6 (ATP-binding cassette sub- family C member 6).

MYH6_MOUSE
θ value	6.88961 (rank : 90)	NC score	-0.001417 (rank : 98)
Query Neighborhood Hits	99	Target Neighborhood Hits	1501	Shared Neighborhood Hits	7
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

RASA2_MOUSE
θ value	6.88961 (rank : 91)	NC score	0.008179 (rank : 82)
Query Neighborhood Hits	99	Target Neighborhood Hits	159	Shared Neighborhood Hits	3
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RRBP1_HUMAN
θ value	6.88961 (rank : 92)	NC score	0.004914 (rank : 91)
Query Neighborhood Hits	99	Target Neighborhood Hits	1306	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

RRBP1_MOUSE
θ value	6.88961 (rank : 93)	NC score	0.002731 (rank : 93)
Query Neighborhood Hits	99	Target Neighborhood Hits	1650	Shared Neighborhood Hits	16
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

CEBPA_MOUSE
θ value	8.99809 (rank : 94)	NC score	0.006770 (rank : 88)
Query Neighborhood Hits	99	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	P53566, Q91XB6	Gene names	Cebpa
Domain Architecture
Description	CCAAT/enhancer-binding protein alpha (C/EBP alpha).

MDC1_HUMAN
θ value	8.99809 (rank : 95)	NC score	0.010459 (rank : 80)
Query Neighborhood Hits	99	Target Neighborhood Hits	1446	Shared Neighborhood Hits	17
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MYH6_HUMAN
θ value	8.99809 (rank : 96)	NC score	-0.001548 (rank : 99)
Query Neighborhood Hits	99	Target Neighborhood Hits	1426	Shared Neighborhood Hits	8
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

PTN23_MOUSE
θ value	8.99809 (rank : 97)	NC score	0.008117 (rank : 83)
Query Neighborhood Hits	99	Target Neighborhood Hits	726	Shared Neighborhood Hits	14
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SGPP1_MOUSE
θ value	8.99809 (rank : 98)	NC score	0.007903 (rank : 84)
Query Neighborhood Hits	99	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI99	Gene names	Sgpp1, Spp1, Spph1
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 1 (EC 3.1.3.-) (Sphingosine-1- phosphatase 1) (SPPase1) (SPP) (mSPP1).

ZN426_HUMAN
θ value	8.99809 (rank : 99)	NC score	-0.002982 (rank : 101)
Query Neighborhood Hits	99	Target Neighborhood Hits	747	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BUY5	Gene names	ZNF426
Domain Architecture
Description	Zinc finger protein 426.

AKA10_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.197124 (rank : 50)
Query Neighborhood Hits	99	Target Neighborhood Hits	58	Shared Neighborhood Hits	35
SwissProt Accessions	O43572, Q96AJ7	Gene names	AKAP10
Domain Architecture
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

AKA10_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.196854 (rank : 51)
Query Neighborhood Hits	99	Target Neighborhood Hits	75	Shared Neighborhood Hits	35
SwissProt Accessions	O88845, Q5SUB5, Q5SUB7, Q7TPE7, Q8BQL6	Gene names	Akap10
Domain Architecture	No domain graphic available
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

Hits sorted by NC score

AXN1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	99	Target Neighborhood Hits	99	Shared Neighborhood Hits	99
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

AXN1_MOUSE
NC score	0.992127 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	99	Target Neighborhood Hits	89	Shared Neighborhood Hits	63
SwissProt Accessions	O35625	Gene names	Axin1, Axin, Fu
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (Fused protein).

AXN2_HUMAN
NC score	0.953621 (rank : 3)	θ value	8.33966e-147 (rank : 3)
Query Neighborhood Hits	99	Target Neighborhood Hits	102	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2T1, Q9H3M6, Q9UH84	Gene names	AXIN2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

AXN2_MOUSE
NC score	0.948670 (rank : 4)	θ value	2.77624e-142 (rank : 4)
Query Neighborhood Hits	99	Target Neighborhood Hits	116	Shared Neighborhood Hits	48
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

RGS10_HUMAN
NC score	0.712747 (rank : 5)	θ value	1.68911e-14 (rank : 6)
Query Neighborhood Hits	99	Target Neighborhood Hits	57	Shared Neighborhood Hits	46
SwissProt Accessions	O43665	Gene names	RGS10
Domain Architecture
Description	Regulator of G-protein signaling 10 (RGS10).

RGS10_MOUSE
NC score	0.705571 (rank : 6)	θ value	1.42992e-13 (rank : 8)
Query Neighborhood Hits	99	Target Neighborhood Hits	57	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CQE5, Q9D3L2	Gene names	Rgs10
Domain Architecture
Description	Regulator of G-protein signaling 10 (RGS10).

RGS18_MOUSE
NC score	0.697968 (rank : 7)	θ value	1.42992e-13 (rank : 9)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	42
SwissProt Accessions	Q99PG4	Gene names	Rgs18
Domain Architecture
Description	Regulator of G-protein signaling 18 (RGS18).

RGS18_HUMAN
NC score	0.697833 (rank : 8)	θ value	3.18553e-13 (rank : 11)
Query Neighborhood Hits	99	Target Neighborhood Hits	44	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NS28	Gene names	RGS18, RGS13
Domain Architecture
Description	Regulator of G-protein signaling 18 (RGS18).

RGS5_HUMAN
NC score	0.692757 (rank : 9)	θ value	1.86753e-13 (rank : 10)
Query Neighborhood Hits	99	Target Neighborhood Hits	52	Shared Neighborhood Hits	45
SwissProt Accessions	O15539	Gene names	RGS5
Domain Architecture
Description	Regulator of G-protein signaling 5 (RGS5).

RGS1_HUMAN
NC score	0.690311 (rank : 10)	θ value	4.16044e-13 (rank : 12)
Query Neighborhood Hits	99	Target Neighborhood Hits	50	Shared Neighborhood Hits	45
SwissProt Accessions	Q08116, Q07918, Q9H1W2	Gene names	RGS1, 1R20, BL34
Domain Architecture
Description	Regulator of G-protein signaling 1 (RGS1) (Early response protein 1R20) (B-cell activation protein BL34).

RGS8_MOUSE
NC score	0.688579 (rank : 11)	θ value	1.58096e-12 (rank : 15)
Query Neighborhood Hits	99	Target Neighborhood Hits	46	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BXT1	Gene names	Rgs8
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 8 (RGS8).

RGS8_HUMAN
NC score	0.687206 (rank : 12)	θ value	1.58096e-12 (rank : 14)
Query Neighborhood Hits	99	Target Neighborhood Hits	45	Shared Neighborhood Hits	43
SwissProt Accessions	P57771, Q3SYD2	Gene names	RGS8
Domain Architecture
Description	Regulator of G-protein signaling 8 (RGS8).

RGS5_MOUSE
NC score	0.685938 (rank : 13)	θ value	1.2105e-12 (rank : 13)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	44
SwissProt Accessions	O08850, Q543B1, Q9D0Z2	Gene names	Rgs5
Domain Architecture
Description	Regulator of G-protein signaling 5 (RGS5).

RGS2_HUMAN
NC score	0.685857 (rank : 14)	θ value	2.28291e-11 (rank : 21)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	44
SwissProt Accessions	P41220	Gene names	RGS2, G0S8
Domain Architecture
Description	Regulator of G-protein signaling 2 (RGS2) (G0/G1 switch regulatory protein 8).

RGS1_MOUSE
NC score	0.684743 (rank : 15)	θ value	2.28291e-11 (rank : 20)
Query Neighborhood Hits	99	Target Neighborhood Hits	60	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JL25, Q3TBD1, Q3TC18, Q3TD56	Gene names	Rgs1
Domain Architecture
Description	Regulator of G-protein signaling 1 (RGS1).

RGS4_MOUSE
NC score	0.683634 (rank : 16)	θ value	1.33837e-11 (rank : 17)
Query Neighborhood Hits	99	Target Neighborhood Hits	46	Shared Neighborhood Hits	43
SwissProt Accessions	O08899, Q99L30	Gene names	Rgs4
Domain Architecture
Description	Regulator of G-protein signaling 4 (RGS4).

RGS2_MOUSE
NC score	0.682622 (rank : 17)	θ value	1.74796e-11 (rank : 18)
Query Neighborhood Hits	99	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	O08849, Q544S7, Q91WX1, Q9JL24	Gene names	Rgs2
Domain Architecture
Description	Regulator of G-protein signaling 2 (RGS2).

RGS4_HUMAN
NC score	0.682085 (rank : 18)	θ value	1.74796e-11 (rank : 19)
Query Neighborhood Hits	99	Target Neighborhood Hits	48	Shared Neighborhood Hits	43
SwissProt Accessions	P49798	Gene names	RGS4
Domain Architecture
Description	Regulator of G-protein signaling 4 (RGS4) (RGP4).

RGS16_MOUSE
NC score	0.676076 (rank : 19)	θ value	3.89403e-11 (rank : 22)
Query Neighborhood Hits	99	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	P97428, O09091, P97420, Q80V16	Gene names	Rgs16, Rgsr
Domain Architecture
Description	Regulator of G-protein signaling 16 (RGS16) (Retinally abundant regulator of G-protein signaling) (RGS-R) (A28-RGS14P).

RGS13_MOUSE
NC score	0.675775 (rank : 20)	θ value	3.29651e-10 (rank : 24)
Query Neighborhood Hits	99	Target Neighborhood Hits	45	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K443	Gene names	Rgs13
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 13 (RGS13).

RGS13_HUMAN
NC score	0.673757 (rank : 21)	θ value	6.21693e-09 (rank : 32)
Query Neighborhood Hits	99	Target Neighborhood Hits	48	Shared Neighborhood Hits	45
SwissProt Accessions	O14921, Q6PGR2, Q8TD63, Q9BX45	Gene names	RGS13
Domain Architecture
Description	Regulator of G-protein signaling 13 (RGS13).

RGS16_HUMAN
NC score	0.670429 (rank : 22)	θ value	5.62301e-10 (rank : 25)
Query Neighborhood Hits	99	Target Neighborhood Hits	45	Shared Neighborhood Hits	42
SwissProt Accessions	O15492, Q99701	Gene names	RGS16, RGSR
Domain Architecture
Description	Regulator of G-protein signaling 16 (RGS16) (Retinally abundant regulator of G-protein signaling) (RGS-R) (A28-RGS14P).

RGS17_MOUSE
NC score	0.663019 (rank : 23)	θ value	3.52202e-12 (rank : 16)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZB0, Q543T9	Gene names	Rgs17, Rgsz2
Domain Architecture
Description	Regulator of G-protein signaling 17 (RGS17) (Regulator of Gz-selective protein signaling 2).

RGS20_MOUSE
NC score	0.658041 (rank : 24)	θ value	2.52405e-10 (rank : 23)
Query Neighborhood Hits	99	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZB1, Q3TY63, Q9CUV8, Q9QZB2	Gene names	Rgs20, Rgsz1
Domain Architecture
Description	Regulator of G-protein signaling 20 (RGS20) (Regulator of G-protein signaling Z1).

RGS19_MOUSE
NC score	0.654540 (rank : 25)	θ value	4.76016e-09 (rank : 31)
Query Neighborhood Hits	99	Target Neighborhood Hits	46	Shared Neighborhood Hits	42
SwissProt Accessions	Q9CX84, Q99L50	Gene names	Rgs19
Domain Architecture
Description	Regulator of G-protein signaling 19 (RGS19).

RGS19_HUMAN
NC score	0.654391 (rank : 26)	θ value	1.63604e-09 (rank : 29)
Query Neighborhood Hits	99	Target Neighborhood Hits	45	Shared Neighborhood Hits	42
SwissProt Accessions	P49795, Q53XN0, Q8TD60	Gene names	RGS19, GAIP, GNAI3IP
Domain Architecture
Description	Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP protein).

RGS17_HUMAN
NC score	0.652308 (rank : 27)	θ value	7.34386e-10 (rank : 27)
Query Neighborhood Hits	99	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UGC6, Q5TF49, Q8TD61, Q9UJS8	Gene names	RGS17
Domain Architecture
Description	Regulator of G-protein signaling 17 (RGS17).

RGS20_HUMAN
NC score	0.646598 (rank : 28)	θ value	9.59137e-10 (rank : 28)
Query Neighborhood Hits	99	Target Neighborhood Hits	55	Shared Neighborhood Hits	42
SwissProt Accessions	O76081, Q96BG9	Gene names	RGS20, RGSZ1, ZGAP1
Domain Architecture
Description	Regulator of G-protein signaling 20 (RGS20) (Regulator of Gz-selective protein signaling 1) (Gz-selective GTPase-activating protein) (G(z)GAP).

RGS14_MOUSE
NC score	0.629383 (rank : 29)	θ value	2.13673e-09 (rank : 30)
Query Neighborhood Hits	99	Target Neighborhood Hits	55	Shared Neighborhood Hits	40
SwissProt Accessions	P97492, Q9DCD1	Gene names	Rgs14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2-interacting protein).

RGS14_HUMAN
NC score	0.621802 (rank : 30)	θ value	7.34386e-10 (rank : 26)
Query Neighborhood Hits	99	Target Neighborhood Hits	77	Shared Neighborhood Hits	42
SwissProt Accessions	O43566, O43565, Q8TD62	Gene names	RGS14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14).

RGS11_HUMAN
NC score	0.553728 (rank : 31)	θ value	5.44631e-05 (rank : 38)
Query Neighborhood Hits	99	Target Neighborhood Hits	68	Shared Neighborhood Hits	50
SwissProt Accessions	O94810, O75883	Gene names	RGS11
Domain Architecture
Description	Regulator of G-protein signaling 11 (RGS11).

RGS9_MOUSE
NC score	0.530727 (rank : 32)	θ value	7.1131e-05 (rank : 39)
Query Neighborhood Hits	99	Target Neighborhood Hits	65	Shared Neighborhood Hits	48
SwissProt Accessions	O54828, Q9Z0S0	Gene names	Rgs9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

RGS9_HUMAN
NC score	0.529709 (rank : 33)	θ value	0.000158464 (rank : 40)
Query Neighborhood Hits	99	Target Neighborhood Hits	64	Shared Neighborhood Hits	48
SwissProt Accessions	O75916, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33	Gene names	RGS9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

RGS12_HUMAN
NC score	0.526789 (rank : 34)	θ value	6.43352e-06 (rank : 33)
Query Neighborhood Hits	99	Target Neighborhood Hits	333	Shared Neighborhood Hits	53
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RGS3_HUMAN
NC score	0.504799 (rank : 35)	θ value	9.90251e-15 (rank : 5)
Query Neighborhood Hits	99	Target Neighborhood Hits	1375	Shared Neighborhood Hits	60
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RGS7_HUMAN
NC score	0.499228 (rank : 36)	θ value	0.00665767 (rank : 46)
Query Neighborhood Hits	99	Target Neighborhood Hits	82	Shared Neighborhood Hits	48
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

RGS7_MOUSE
NC score	0.491638 (rank : 37)	θ value	0.0431538 (rank : 51)
Query Neighborhood Hits	99	Target Neighborhood Hits	79	Shared Neighborhood Hits	49
SwissProt Accessions	O54829	Gene names	Rgs7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

RGS6_MOUSE
NC score	0.478737 (rank : 38)	θ value	0.279714 (rank : 57)
Query Neighborhood Hits	99	Target Neighborhood Hits	71	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

RGS6_HUMAN
NC score	0.448389 (rank : 39)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	99	Target Neighborhood Hits	80	Shared Neighborhood Hits	44
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

RGS3_MOUSE
NC score	0.444140 (rank : 40)	θ value	4.91457e-14 (rank : 7)
Query Neighborhood Hits	99	Target Neighborhood Hits	1621	Shared Neighborhood Hits	56
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

DVL3_MOUSE
NC score	0.237240 (rank : 41)	θ value	1.87187e-05 (rank : 37)
Query Neighborhood Hits	99	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
NC score	0.237050 (rank : 42)	θ value	1.87187e-05 (rank : 36)
Query Neighborhood Hits	99	Target Neighborhood Hits	194	Shared Neighborhood Hits	18
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL2_MOUSE
NC score	0.230702 (rank : 43)	θ value	1.43324e-05 (rank : 35)
Query Neighborhood Hits	99	Target Neighborhood Hits	233	Shared Neighborhood Hits	21
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
NC score	0.230057 (rank : 44)	θ value	1.43324e-05 (rank : 34)
Query Neighborhood Hits	99	Target Neighborhood Hits	223	Shared Neighborhood Hits	18
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

SNX13_HUMAN
NC score	0.226296 (rank : 45)	θ value	0.0961366 (rank : 53)
Query Neighborhood Hits	99	Target Neighborhood Hits	84	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y5W8, O94821, Q8WVZ2, Q8WXH8	Gene names	SNX13, KIAA0713
Domain Architecture
Description	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1).

SNX13_MOUSE
NC score	0.226263 (rank : 46)	θ value	0.0961366 (rank : 54)
Query Neighborhood Hits	99	Target Neighborhood Hits	86	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PHS6	Gene names	Snx13
Domain Architecture	No domain graphic available
Description	Sorting nexin-13.

DVL1L_HUMAN
NC score	0.213538 (rank : 47)	θ value	0.000602161 (rank : 41)
Query Neighborhood Hits	99	Target Neighborhood Hits	146	Shared Neighborhood Hits	16
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_MOUSE
NC score	0.211388 (rank : 48)	θ value	0.000602161 (rank : 43)
Query Neighborhood Hits	99	Target Neighborhood Hits	146	Shared Neighborhood Hits	16
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_HUMAN
NC score	0.211332 (rank : 49)	θ value	0.000602161 (rank : 42)
Query Neighborhood Hits	99	Target Neighborhood Hits	158	Shared Neighborhood Hits	17
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

AKA10_HUMAN
NC score	0.197124 (rank : 50)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	99	Target Neighborhood Hits	58	Shared Neighborhood Hits	35
SwissProt Accessions	O43572, Q96AJ7	Gene names	AKAP10
Domain Architecture
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

AKA10_MOUSE
NC score	0.196854 (rank : 51)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	99	Target Neighborhood Hits	75	Shared Neighborhood Hits	35
SwissProt Accessions	O88845, Q5SUB5, Q5SUB7, Q7TPE7, Q8BQL6	Gene names	Akap10
Domain Architecture	No domain graphic available
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

SNX14_MOUSE
NC score	0.152639 (rank : 52)	θ value	0.00175202 (rank : 45)
Query Neighborhood Hits	99	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

SNX14_HUMAN
NC score	0.152386 (rank : 53)	θ value	0.00175202 (rank : 44)
Query Neighborhood Hits	99	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

SNX25_HUMAN
NC score	0.115270 (rank : 54)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	99	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H3E2	Gene names	SNX25
Domain Architecture
Description	Sorting nexin-25.

CT151_HUMAN
NC score	0.067573 (rank : 55)	θ value	0.0193708 (rank : 49)
Query Neighborhood Hits	99	Target Neighborhood Hits	382	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

MARCS_MOUSE
NC score	0.054881 (rank : 56)	θ value	0.0961366 (rank : 52)
Query Neighborhood Hits	99	Target Neighborhood Hits	227	Shared Neighborhood Hits	11
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

CD2_HUMAN
NC score	0.045414 (rank : 57)	θ value	0.125558 (rank : 55)
Query Neighborhood Hits	99	Target Neighborhood Hits	504	Shared Neighborhood Hits	12
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

PDZD2_HUMAN
NC score	0.045217 (rank : 58)	θ value	0.813845 (rank : 61)
Query Neighborhood Hits	99	Target Neighborhood Hits	772	Shared Neighborhood Hits	29
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

BAZ1B_HUMAN
NC score	0.041399 (rank : 59)	θ value	0.0330416 (rank : 50)
Query Neighborhood Hits	99	Target Neighborhood Hits	701	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

EP300_HUMAN
NC score	0.036376 (rank : 60)	θ value	0.62314 (rank : 58)
Query Neighborhood Hits	99	Target Neighborhood Hits	821	Shared Neighborhood Hits	14
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

K1949_HUMAN
NC score	0.035163 (rank : 61)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	99	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q6NYC8, Q68CK8, Q6ZUJ6, Q8NDQ4, Q8TF52, Q9BRL9	Gene names	KIAA1949
Domain Architecture	No domain graphic available
Description	Protein KIAA1949.

CBP_HUMAN
NC score	0.031655 (rank : 62)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	99	Target Neighborhood Hits	941	Shared Neighborhood Hits	16
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CDSN_MOUSE
NC score	0.031287 (rank : 63)	θ value	0.813845 (rank : 60)
Query Neighborhood Hits	99	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

ES8L1_HUMAN
NC score	0.030856 (rank : 64)	θ value	0.21417 (rank : 56)
Query Neighborhood Hits	99	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

CBP_MOUSE
NC score	0.028563 (rank : 65)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	99	Target Neighborhood Hits	1051	Shared Neighborhood Hits	15
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

K1949_MOUSE
NC score	0.028397 (rank : 66)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	99	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

ES8L1_MOUSE
NC score	0.027935 (rank : 67)	θ value	0.62314 (rank : 59)
Query Neighborhood Hits	99	Target Neighborhood Hits	143	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SRCA_HUMAN
NC score	0.025487 (rank : 68)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	99	Target Neighborhood Hits	380	Shared Neighborhood Hits	13
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

ARBK1_HUMAN
NC score	0.023388 (rank : 69)	θ value	0.0113563 (rank : 47)
Query Neighborhood Hits	99	Target Neighborhood Hits	859	Shared Neighborhood Hits	18
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

SRRM2_MOUSE
NC score	0.022364 (rank : 70)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	99	Target Neighborhood Hits	1470	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ARBK1_MOUSE
NC score	0.020146 (rank : 71)	θ value	0.0113563 (rank : 48)
Query Neighborhood Hits	99	Target Neighborhood Hits	849	Shared Neighborhood Hits	14
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK2_HUMAN
NC score	0.019144 (rank : 72)	θ value	1.38821 (rank : 64)
Query Neighborhood Hits	99	Target Neighborhood Hits	849	Shared Neighborhood Hits	17
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

PK3C3_MOUSE
NC score	0.018634 (rank : 73)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
NC score	0.018624 (rank : 74)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

OGFR_HUMAN
NC score	0.017771 (rank : 75)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	99	Target Neighborhood Hits	1582	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PPRB_HUMAN
NC score	0.015127 (rank : 76)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	99	Target Neighborhood Hits	311	Shared Neighborhood Hits	11
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

SPAG1_MOUSE
NC score	0.013258 (rank : 77)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	99	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	Q80ZX8, Q8CCK7, Q9QZJ3, Q9QZJ4	Gene names	Spag1, Tpis
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS).

RGP2_HUMAN
NC score	0.011589 (rank : 78)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	99	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

SVIL_MOUSE
NC score	0.010507 (rank : 79)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	99	Target Neighborhood Hits	439	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

MDC1_HUMAN
NC score	0.010459 (rank : 80)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	99	Target Neighborhood Hits	1446	Shared Neighborhood Hits	17
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

GATA3_MOUSE
NC score	0.009830 (rank : 81)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	99	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	P23772	Gene names	Gata3, Gata-3
Domain Architecture
Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3).

RASA2_MOUSE
NC score	0.008179 (rank : 82)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	99	Target Neighborhood Hits	159	Shared Neighborhood Hits	3
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

PTN23_MOUSE
NC score	0.008117 (rank : 83)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	99	Target Neighborhood Hits	726	Shared Neighborhood Hits	14
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SGPP1_MOUSE
NC score	0.007903 (rank : 84)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	99	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI99	Gene names	Sgpp1, Spp1, Spph1
Domain Architecture
Description	Sphingosine-1-phosphate phosphatase 1 (EC 3.1.3.-) (Sphingosine-1- phosphatase 1) (SPPase1) (SPP) (mSPP1).

CAC1C_HUMAN
NC score	0.007143 (rank : 85)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	99	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

ZHX2_HUMAN
NC score	0.006922 (rank : 86)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	99	Target Neighborhood Hits	347	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6X8	Gene names	ZHX2, AFR1, KIAA0854, RAF
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

DDX49_HUMAN
NC score	0.006809 (rank : 87)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	99	Target Neighborhood Hits	223	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

CEBPA_MOUSE
NC score	0.006770 (rank : 88)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	99	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	P53566, Q91XB6	Gene names	Cebpa
Domain Architecture
Description	CCAAT/enhancer-binding protein alpha (C/EBP alpha).

FOXJ3_HUMAN
NC score	0.006290 (rank : 89)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	99	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

FOXJ3_MOUSE
NC score	0.005839 (rank : 90)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	99	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUR3, Q3UTD8	Gene names	Foxj3, Kiaa1041
Domain Architecture
Description	Forkhead box protein J3.

RRBP1_HUMAN
NC score	0.004914 (rank : 91)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	99	Target Neighborhood Hits	1306	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

MAST4_HUMAN
NC score	0.004278 (rank : 92)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	99	Target Neighborhood Hits	1804	Shared Neighborhood Hits	25
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

RRBP1_MOUSE
NC score	0.002731 (rank : 93)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	99	Target Neighborhood Hits	1650	Shared Neighborhood Hits	16
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

MRP6_MOUSE
NC score	0.002358 (rank : 94)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	99	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1S7, Q80YB6	Gene names	Abcc6, Mrp6
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 6 (ATP-binding cassette sub- family C member 6).

MSX2_MOUSE
NC score	0.000802 (rank : 95)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	99	Target Neighborhood Hits	345	Shared Neighborhood Hits	2
SwissProt Accessions	Q03358, Q63856	Gene names	Msx2, Hox-8.1, Msx-2
Domain Architecture
Description	Homeobox protein MSX-2 (Hox-8.1).

LRP1_HUMAN
NC score	-0.000299 (rank : 96)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	99	Target Neighborhood Hits	617	Shared Neighborhood Hits	2
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

ZN358_HUMAN
NC score	-0.001066 (rank : 97)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	99	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

MYH6_MOUSE
NC score	-0.001417 (rank : 98)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	99	Target Neighborhood Hits	1501	Shared Neighborhood Hits	7
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_HUMAN
NC score	-0.001548 (rank : 99)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	99	Target Neighborhood Hits	1426	Shared Neighborhood Hits	8
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

ZN333_HUMAN
NC score	-0.002316 (rank : 100)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	99	Target Neighborhood Hits	750	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JL9, Q8TDL0	Gene names	ZNF333, KIAA1806
Domain Architecture
Description	Zinc finger protein 333.

ZN426_HUMAN
NC score	-0.002982 (rank : 101)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	99	Target Neighborhood Hits	747	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BUY5	Gene names	ZNF426
Domain Architecture
Description	Zinc finger protein 426.