Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PK3C3_HUMAN

For an explanation of this page, click here

PK3C3_HUMAN
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PK3C3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	0 (rank : 2)	NC score	0.999368 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CG_HUMAN
θ value	6.7944e-48 (rank : 3)	NC score	0.877287 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	1.51363e-47 (rank : 4)	NC score	0.875993 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CD_HUMAN
θ value	1.19932e-44 (rank : 5)	NC score	0.866173 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	40	Shared Neighborhood Hits	29
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	7.77379e-44 (rank : 6)	NC score	0.865530 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	42	Shared Neighborhood Hits	29
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

P3C2A_MOUSE
θ value	1.73182e-43 (rank : 7)	NC score	0.763152 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
θ value	5.03882e-43 (rank : 8)	NC score	0.760195 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PK3CB_MOUSE
θ value	1.91475e-42 (rank : 9)	NC score	0.863574 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

P3C2G_MOUSE
θ value	2.50074e-42 (rank : 10)	NC score	0.843530 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
θ value	4.2656e-42 (rank : 11)	NC score	0.844506 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3CB_HUMAN
θ value	5.57106e-42 (rank : 12)	NC score	0.863147 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CA_HUMAN
θ value	3.99248e-40 (rank : 13)	NC score	0.858057 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	3.99248e-40 (rank : 14)	NC score	0.857962 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	48	Shared Neighborhood Hits	29
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2B_HUMAN
θ value	5.76516e-39 (rank : 15)	NC score	0.734868 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PI4KB_HUMAN
θ value	1.12775e-26 (rank : 16)	NC score	0.803833 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	1.12775e-26 (rank : 17)	NC score	0.804928 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KA_HUMAN
θ value	5.59698e-26 (rank : 18)	NC score	0.812347 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

ATM_MOUSE
θ value	8.38298e-14 (rank : 19)	NC score	0.469612 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

FRAP_MOUSE
θ value	9.26847e-13 (rank : 20)	NC score	0.519403 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	77	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
θ value	1.58096e-12 (rank : 21)	NC score	0.517949 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	83	Shared Neighborhood Hits	30
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATM_HUMAN
θ value	2.0648e-12 (rank : 22)	NC score	0.474562 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

PRKDC_MOUSE
θ value	1.133e-10 (rank : 23)	NC score	0.472772 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ATR_HUMAN
θ value	1.25267e-09 (rank : 24)	NC score	0.461052 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	2.13673e-09 (rank : 25)	NC score	0.461092 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	63	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

PRKDC_HUMAN
θ value	6.43352e-06 (rank : 26)	NC score	0.448473 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

SMG1_HUMAN
θ value	6.43352e-06 (rank : 27)	NC score	0.373859 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	6.43352e-06 (rank : 28)	NC score	0.376406 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	212	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

TS101_HUMAN
θ value	0.0961366 (rank : 29)	NC score	0.070973 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	359	Shared Neighborhood Hits	7
SwissProt Accessions	Q99816, Q9BUM5	Gene names	TSG101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

TS101_MOUSE
θ value	0.125558 (rank : 30)	NC score	0.071695 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	312	Shared Neighborhood Hits	7
SwissProt Accessions	Q61187	Gene names	Tsg101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

ERC2_MOUSE
θ value	0.279714 (rank : 31)	NC score	0.015279 (rank : 52)
Query Neighborhood Hits	49	Target Neighborhood Hits	1166	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ERC2_HUMAN
θ value	0.47712 (rank : 32)	NC score	0.014249 (rank : 54)
Query Neighborhood Hits	49	Target Neighborhood Hits	1156	Shared Neighborhood Hits	9
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

AXN1_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.018624 (rank : 50)
Query Neighborhood Hits	49	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

STRN4_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.004454 (rank : 62)
Query Neighborhood Hits	49	Target Neighborhood Hits	325	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRL3	Gene names	STRN4, ZIN
Domain Architecture
Description	Striatin-4 (Zinedin).

TRRAP_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.112414 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

YLPM1_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.011698 (rank : 56)
Query Neighborhood Hits	49	Target Neighborhood Hits	670	Shared Neighborhood Hits	3
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

DESP_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.003515 (rank : 63)
Query Neighborhood Hits	49	Target Neighborhood Hits	1470	Shared Neighborhood Hits	9
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

MKRN2_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.014409 (rank : 53)
Query Neighborhood Hits	49	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H000, Q8N391, Q96BD4, Q9BUY2, Q9NRY1	Gene names	MKRN2, RNF62
Domain Architecture
Description	Makorin-2 (RING finger protein 62).

AXN1_MOUSE
θ value	5.27518 (rank : 39)	NC score	0.015978 (rank : 51)
Query Neighborhood Hits	49	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	O35625	Gene names	Axin1, Axin, Fu
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (Fused protein).

BUP1_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.030611 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UBR1, Q9UIR3	Gene names	UPB1, BUP1
Domain Architecture
Description	Beta-ureidopropionase (EC 3.5.1.6) (Beta-alanine synthase) (N- carbamoyl-beta-alanine amidohydrolase) (BUP-1).

DHX34_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.007583 (rank : 60)
Query Neighborhood Hits	49	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

C1TC_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.013574 (rank : 55)
Query Neighborhood Hits	49	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

DNAL4_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.021505 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DCM4, O54793, Q3V233, Q99K65	Gene names	Dnal4, Dnalc4
Domain Architecture
Description	Dynein light chain 4, axonemal.

MELPH_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.010686 (rank : 58)
Query Neighborhood Hits	49	Target Neighborhood Hits	145	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

NARGL_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.008656 (rank : 59)
Query Neighborhood Hits	49	Target Neighborhood Hits	175	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBB4, Q3U7V2	Gene names	Narg1l, Nat2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

TOP2A_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.005139 (rank : 61)
Query Neighborhood Hits	49	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	Q01320	Gene names	Top2a, Top-2, Top2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

TRRAP_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.108932 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

TSH1_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.002532 (rank : 64)
Query Neighborhood Hits	49	Target Neighborhood Hits	558	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZSZ6, O60534, Q4LE29, Q53EU4	Gene names	TSHZ1, SDCCAG33, TSH1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3) (Antigen NY-CO-33).

UBP10_MOUSE
θ value	8.99809 (rank : 49)	NC score	0.010843 (rank : 57)
Query Neighborhood Hits	49	Target Neighborhood Hits	150	Shared Neighborhood Hits	3
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

FA62A_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.065848 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.073872 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RIMS1_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.062390 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	437	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.053050 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.053064 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS4_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.075787 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.075780 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYTL1_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.056075 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL1_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.052295 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	314	Shared Neighborhood Hits	7
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.051031 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	248	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL3_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.066562 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.051238 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.051050 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	137	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.055220 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	237	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.054580 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	154	Shared Neighborhood Hits	6
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

Hits sorted by NC score

PK3C3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.999368 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CG_HUMAN
NC score	0.877287 (rank : 3)	θ value	6.7944e-48 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.875993 (rank : 4)	θ value	1.51363e-47 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CD_HUMAN
NC score	0.866173 (rank : 5)	θ value	1.19932e-44 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	40	Shared Neighborhood Hits	29
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
NC score	0.865530 (rank : 6)	θ value	7.77379e-44 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	42	Shared Neighborhood Hits	29
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_MOUSE
NC score	0.863574 (rank : 7)	θ value	1.91475e-42 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
NC score	0.863147 (rank : 8)	θ value	5.57106e-42 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CA_HUMAN
NC score	0.858057 (rank : 9)	θ value	3.99248e-40 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.857962 (rank : 10)	θ value	3.99248e-40 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	48	Shared Neighborhood Hits	29
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_HUMAN
NC score	0.844506 (rank : 11)	θ value	4.2656e-42 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_MOUSE
NC score	0.843530 (rank : 12)	θ value	2.50074e-42 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KA_HUMAN
NC score	0.812347 (rank : 13)	θ value	5.59698e-26 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PI4KB_MOUSE
NC score	0.804928 (rank : 14)	θ value	1.12775e-26 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KB_HUMAN
NC score	0.803833 (rank : 15)	θ value	1.12775e-26 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

P3C2A_MOUSE
NC score	0.763152 (rank : 16)	θ value	1.73182e-43 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.760195 (rank : 17)	θ value	5.03882e-43 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.734868 (rank : 18)	θ value	5.76516e-39 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

FRAP_MOUSE
NC score	0.519403 (rank : 19)	θ value	9.26847e-13 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	77	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.517949 (rank : 20)	θ value	1.58096e-12 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	83	Shared Neighborhood Hits	30
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATM_HUMAN
NC score	0.474562 (rank : 21)	θ value	2.0648e-12 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

PRKDC_MOUSE
NC score	0.472772 (rank : 22)	θ value	1.133e-10 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ATM_MOUSE
NC score	0.469612 (rank : 23)	θ value	8.38298e-14 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATR_MOUSE
NC score	0.461092 (rank : 24)	θ value	2.13673e-09 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	63	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATR_HUMAN
NC score	0.461052 (rank : 25)	θ value	1.25267e-09 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

PRKDC_HUMAN
NC score	0.448473 (rank : 26)	θ value	6.43352e-06 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

SMG1_MOUSE
NC score	0.376406 (rank : 27)	θ value	6.43352e-06 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	212	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.373859 (rank : 28)	θ value	6.43352e-06 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

TRRAP_HUMAN
NC score	0.112414 (rank : 29)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
NC score	0.108932 (rank : 30)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

RIMS4_HUMAN
NC score	0.075787 (rank : 31)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	49	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
NC score	0.075780 (rank : 32)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	49	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

FA62A_MOUSE
NC score	0.073872 (rank : 33)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	49	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

TS101_MOUSE
NC score	0.071695 (rank : 34)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	312	Shared Neighborhood Hits	7
SwissProt Accessions	Q61187	Gene names	Tsg101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

TS101_HUMAN
NC score	0.070973 (rank : 35)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	359	Shared Neighborhood Hits	7
SwissProt Accessions	Q99816, Q9BUM5	Gene names	TSG101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

SYTL3_MOUSE
NC score	0.066562 (rank : 36)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	49	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

FA62A_HUMAN
NC score	0.065848 (rank : 37)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	49	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RIMS1_HUMAN
NC score	0.062390 (rank : 38)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	49	Target Neighborhood Hits	437	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SYTL1_HUMAN
NC score	0.056075 (rank : 39)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	49	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL5_HUMAN
NC score	0.055220 (rank : 40)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	49	Target Neighborhood Hits	237	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
NC score	0.054580 (rank : 41)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	49	Target Neighborhood Hits	154	Shared Neighborhood Hits	6
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

RIMS2_MOUSE
NC score	0.053064 (rank : 42)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	49	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
NC score	0.053050 (rank : 43)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	49	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

SYTL1_MOUSE
NC score	0.052295 (rank : 44)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	49	Target Neighborhood Hits	314	Shared Neighborhood Hits	7
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL4_HUMAN
NC score	0.051238 (rank : 45)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	49	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
NC score	0.051050 (rank : 46)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	49	Target Neighborhood Hits	137	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL2_HUMAN
NC score	0.051031 (rank : 47)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	49	Target Neighborhood Hits	248	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

BUP1_HUMAN
NC score	0.030611 (rank : 48)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UBR1, Q9UIR3	Gene names	UPB1, BUP1
Domain Architecture
Description	Beta-ureidopropionase (EC 3.5.1.6) (Beta-alanine synthase) (N- carbamoyl-beta-alanine amidohydrolase) (BUP-1).

DNAL4_MOUSE
NC score	0.021505 (rank : 49)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DCM4, O54793, Q3V233, Q99K65	Gene names	Dnal4, Dnalc4
Domain Architecture
Description	Dynein light chain 4, axonemal.

AXN1_HUMAN
NC score	0.018624 (rank : 50)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

AXN1_MOUSE
NC score	0.015978 (rank : 51)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	O35625	Gene names	Axin1, Axin, Fu
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (Fused protein).

ERC2_MOUSE
NC score	0.015279 (rank : 52)	θ value	0.279714 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	1166	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

MKRN2_HUMAN
NC score	0.014409 (rank : 53)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H000, Q8N391, Q96BD4, Q9BUY2, Q9NRY1	Gene names	MKRN2, RNF62
Domain Architecture
Description	Makorin-2 (RING finger protein 62).

ERC2_HUMAN
NC score	0.014249 (rank : 54)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	1156	Shared Neighborhood Hits	9
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

C1TC_HUMAN
NC score	0.013574 (rank : 55)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

YLPM1_HUMAN
NC score	0.011698 (rank : 56)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	670	Shared Neighborhood Hits	3
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

UBP10_MOUSE
NC score	0.010843 (rank : 57)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	150	Shared Neighborhood Hits	3
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

MELPH_HUMAN
NC score	0.010686 (rank : 58)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	145	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

NARGL_MOUSE
NC score	0.008656 (rank : 59)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	175	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBB4, Q3U7V2	Gene names	Narg1l, Nat2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

DHX34_MOUSE
NC score	0.007583 (rank : 60)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

TOP2A_MOUSE
NC score	0.005139 (rank : 61)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	Q01320	Gene names	Top2a, Top-2, Top2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

STRN4_HUMAN
NC score	0.004454 (rank : 62)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	325	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRL3	Gene names	STRN4, ZIN
Domain Architecture
Description	Striatin-4 (Zinedin).

DESP_HUMAN
NC score	0.003515 (rank : 63)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	1470	Shared Neighborhood Hits	9
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

TSH1_HUMAN
NC score	0.002532 (rank : 64)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	558	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZSZ6, O60534, Q4LE29, Q53EU4	Gene names	TSHZ1, SDCCAG33, TSH1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3) (Antigen NY-CO-33).