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Network neighborhood for query Sequence : PK3CB_HUMAN

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PK3CB_HUMAN
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PK3CA_HUMAN
θ value	0 (rank : 1)	NC score	0.979301 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	0 (rank : 2)	NC score	0.979415 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CB_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	0 (rank : 4)	NC score	0.999525 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
θ value	0 (rank : 5)	NC score	0.993666 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	0 (rank : 6)	NC score	0.993374 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CG_MOUSE
θ value	5.05951e-144 (rank : 7)	NC score	0.963376 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_HUMAN
θ value	9.87422e-140 (rank : 8)	NC score	0.963248 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

P3C2A_HUMAN
θ value	3.21347e-98 (rank : 9)	NC score	0.821205 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	2.15548e-94 (rank : 10)	NC score	0.822657 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	7.66637e-92 (rank : 11)	NC score	0.798749 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2G_MOUSE
θ value	4.22625e-74 (rank : 12)	NC score	0.891618 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
θ value	8.53533e-67 (rank : 13)	NC score	0.890416 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3C3_HUMAN
θ value	5.57106e-42 (rank : 14)	NC score	0.863147 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	1.62093e-41 (rank : 15)	NC score	0.861872 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PI4KA_HUMAN
θ value	1.62847e-25 (rank : 16)	NC score	0.804736 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PI4KB_MOUSE
θ value	2.20094e-22 (rank : 17)	NC score	0.767855 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KB_HUMAN
θ value	2.87452e-22 (rank : 18)	NC score	0.765674 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PRKDC_HUMAN
θ value	2.52405e-10 (rank : 19)	NC score	0.422747 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PRKDC_MOUSE
θ value	3.29651e-10 (rank : 20)	NC score	0.427825 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ATM_HUMAN
θ value	1.80886e-08 (rank : 21)	NC score	0.379977 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
θ value	1.80886e-08 (rank : 22)	NC score	0.370256 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_HUMAN
θ value	2.36244e-08 (rank : 23)	NC score	0.327165 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	231	Shared Neighborhood Hits	29
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	2.36244e-08 (rank : 24)	NC score	0.329764 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	212	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

FRAP_MOUSE
θ value	5.26297e-08 (rank : 25)	NC score	0.435011 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
θ value	8.97725e-08 (rank : 26)	NC score	0.433447 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATR_HUMAN
θ value	1.09739e-05 (rank : 27)	NC score	0.367675 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	3.19293e-05 (rank : 28)	NC score	0.365528 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

AKAP1_HUMAN
θ value	0.813845 (rank : 29)	NC score	0.036526 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

AKAP1_MOUSE
θ value	0.813845 (rank : 30)	NC score	0.034929 (rank : 48)
Query Neighborhood Hits	43	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

BIRC6_HUMAN
θ value	1.06291 (rank : 31)	NC score	0.019056 (rank : 49)
Query Neighborhood Hits	43	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

KPCT_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.000541 (rank : 56)
Query Neighborhood Hits	43	Target Neighborhood Hits	897	Shared Neighborhood Hits	8
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

UTRO_HUMAN
θ value	1.81305 (rank : 33)	NC score	0.005286 (rank : 52)
Query Neighborhood Hits	43	Target Neighborhood Hits	960	Shared Neighborhood Hits	5
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

CADH6_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.001326 (rank : 55)
Query Neighborhood Hits	43	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	P55285, Q9BWS0	Gene names	CDH6
Domain Architecture
Description	Cadherin-6 precursor (Kidney-cadherin) (K-cadherin).

KPCT_MOUSE
θ value	4.03905 (rank : 35)	NC score	-0.000155 (rank : 57)
Query Neighborhood Hits	43	Target Neighborhood Hits	895	Shared Neighborhood Hits	8
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

ONCO_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.016911 (rank : 50)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	P32930	Gene names	OCM, OCMN
Domain Architecture
Description	Oncomodulin (OM) (Parvalbumin beta).

3BP1_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.002191 (rank : 54)
Query Neighborhood Hits	43	Target Neighborhood Hits	376	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CDK9_MOUSE
θ value	6.88961 (rank : 38)	NC score	-0.001840 (rank : 58)
Query Neighborhood Hits	43	Target Neighborhood Hits	822	Shared Neighborhood Hits	7
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

ROCK1_HUMAN
θ value	6.88961 (rank : 39)	NC score	-0.002121 (rank : 60)
Query Neighborhood Hits	43	Target Neighborhood Hits	2000	Shared Neighborhood Hits	10
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	6.88961 (rank : 40)	NC score	-0.002338 (rank : 61)
Query Neighborhood Hits	43	Target Neighborhood Hits	2126	Shared Neighborhood Hits	10
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

CDK9_HUMAN
θ value	8.99809 (rank : 41)	NC score	-0.001991 (rank : 59)
Query Neighborhood Hits	43	Target Neighborhood Hits	822	Shared Neighborhood Hits	7
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

MTDC_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.010135 (rank : 51)
Query Neighborhood Hits	43	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

STAT6_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.004322 (rank : 53)
Query Neighborhood Hits	43	Target Neighborhood Hits	132	Shared Neighborhood Hits	4
SwissProt Accessions	P42226	Gene names	STAT6
Domain Architecture
Description	Signal transducer and activator of transcription 6 (IL-4 Stat).

FA62A_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.070871 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.079573 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RIMS1_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.065932 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	437	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.056200 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.056174 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS4_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.080251 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.080252 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYTL1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.060133 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL1_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.056340 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	314	Shared Neighborhood Hits	4
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.053474 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	248	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.052253 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	253	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL3_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.070303 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.054515 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.054182 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.058797 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	237	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.058241 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TRRAP_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.064566 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.064353 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

Hits sorted by NC score

PK3CB_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
NC score	0.999525 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
NC score	0.993666 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
NC score	0.993374 (rank : 4)	θ value	0 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CA_MOUSE
NC score	0.979415 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_HUMAN
NC score	0.979301 (rank : 6)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CG_MOUSE
NC score	0.963376 (rank : 7)	θ value	5.05951e-144 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_HUMAN
NC score	0.963248 (rank : 8)	θ value	9.87422e-140 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

P3C2G_MOUSE
NC score	0.891618 (rank : 9)	θ value	4.22625e-74 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
NC score	0.890416 (rank : 10)	θ value	8.53533e-67 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3C3_HUMAN
NC score	0.863147 (rank : 11)	θ value	5.57106e-42 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.861872 (rank : 12)	θ value	1.62093e-41 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

P3C2A_MOUSE
NC score	0.822657 (rank : 13)	θ value	2.15548e-94 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.821205 (rank : 14)	θ value	3.21347e-98 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PI4KA_HUMAN
NC score	0.804736 (rank : 15)	θ value	1.62847e-25 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2B_HUMAN
NC score	0.798749 (rank : 16)	θ value	7.66637e-92 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PI4KB_MOUSE
NC score	0.767855 (rank : 17)	θ value	2.20094e-22 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KB_HUMAN
NC score	0.765674 (rank : 18)	θ value	2.87452e-22 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

FRAP_MOUSE
NC score	0.435011 (rank : 19)	θ value	5.26297e-08 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.433447 (rank : 20)	θ value	8.97725e-08 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

PRKDC_MOUSE
NC score	0.427825 (rank : 21)	θ value	3.29651e-10 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.422747 (rank : 22)	θ value	2.52405e-10 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

ATM_HUMAN
NC score	0.379977 (rank : 23)	θ value	1.80886e-08 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
NC score	0.370256 (rank : 24)	θ value	1.80886e-08 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATR_HUMAN
NC score	0.367675 (rank : 25)	θ value	1.09739e-05 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.365528 (rank : 26)	θ value	3.19293e-05 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

SMG1_MOUSE
NC score	0.329764 (rank : 27)	θ value	2.36244e-08 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	212	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.327165 (rank : 28)	θ value	2.36244e-08 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	231	Shared Neighborhood Hits	29
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

RIMS4_MOUSE
NC score	0.080252 (rank : 29)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	43	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.080251 (rank : 30)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	43	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

FA62A_MOUSE
NC score	0.079573 (rank : 31)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_HUMAN
NC score	0.070871 (rank : 32)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL3_MOUSE
NC score	0.070303 (rank : 33)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	43	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

RIMS1_HUMAN
NC score	0.065932 (rank : 34)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	437	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

TRRAP_HUMAN
NC score	0.064566 (rank : 35)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	43	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
NC score	0.064353 (rank : 36)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

SYTL1_HUMAN
NC score	0.060133 (rank : 37)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	43	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL5_HUMAN
NC score	0.058797 (rank : 38)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	43	Target Neighborhood Hits	237	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
NC score	0.058241 (rank : 39)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	43	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL1_MOUSE
NC score	0.056340 (rank : 40)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	43	Target Neighborhood Hits	314	Shared Neighborhood Hits	4
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

RIMS2_HUMAN
NC score	0.056200 (rank : 41)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.056174 (rank : 42)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	43	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SYTL4_HUMAN
NC score	0.054515 (rank : 43)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	43	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
NC score	0.054182 (rank : 44)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	43	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL2_HUMAN
NC score	0.053474 (rank : 45)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	43	Target Neighborhood Hits	248	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
NC score	0.052253 (rank : 46)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	43	Target Neighborhood Hits	253	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

AKAP1_HUMAN
NC score	0.036526 (rank : 47)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

AKAP1_MOUSE
NC score	0.034929 (rank : 48)	θ value	0.813845 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

BIRC6_HUMAN
NC score	0.019056 (rank : 49)	θ value	1.06291 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

ONCO_HUMAN
NC score	0.016911 (rank : 50)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	P32930	Gene names	OCM, OCMN
Domain Architecture
Description	Oncomodulin (OM) (Parvalbumin beta).

MTDC_MOUSE
NC score	0.010135 (rank : 51)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

UTRO_HUMAN
NC score	0.005286 (rank : 52)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	960	Shared Neighborhood Hits	5
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

STAT6_HUMAN
NC score	0.004322 (rank : 53)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	132	Shared Neighborhood Hits	4
SwissProt Accessions	P42226	Gene names	STAT6
Domain Architecture
Description	Signal transducer and activator of transcription 6 (IL-4 Stat).

3BP1_HUMAN
NC score	0.002191 (rank : 54)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	376	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CADH6_HUMAN
NC score	0.001326 (rank : 55)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	P55285, Q9BWS0	Gene names	CDH6
Domain Architecture
Description	Cadherin-6 precursor (Kidney-cadherin) (K-cadherin).

KPCT_HUMAN
NC score	0.000541 (rank : 56)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	897	Shared Neighborhood Hits	8
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
NC score	-0.000155 (rank : 57)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	895	Shared Neighborhood Hits	8
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

CDK9_MOUSE
NC score	-0.001840 (rank : 58)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	822	Shared Neighborhood Hits	7
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDK9_HUMAN
NC score	-0.001991 (rank : 59)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	822	Shared Neighborhood Hits	7
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

ROCK1_HUMAN
NC score	-0.002121 (rank : 60)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	2000	Shared Neighborhood Hits	10
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
NC score	-0.002338 (rank : 61)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	2126	Shared Neighborhood Hits	10
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).