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Network neighborhood for query Sequence : PK3CG_HUMAN

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PK3CG_HUMAN
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PK3CG_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	0 (rank : 2)	NC score	0.999490 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CA_HUMAN
θ value	1.32836e-152 (rank : 3)	NC score	0.966483 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	3.27187e-151 (rank : 4)	NC score	0.966367 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CB_MOUSE
θ value	3.06949e-141 (rank : 5)	NC score	0.963447 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
θ value	9.87422e-140 (rank : 6)	NC score	0.963248 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
θ value	5.41814e-138 (rank : 7)	NC score	0.964303 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	1.12976e-135 (rank : 8)	NC score	0.963567 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

P3C2A_HUMAN
θ value	6.90186e-109 (rank : 9)	NC score	0.835304 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	3.42535e-108 (rank : 10)	NC score	0.837909 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	2.01279e-100 (rank : 11)	NC score	0.812177 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2G_MOUSE
θ value	1.95407e-87 (rank : 12)	NC score	0.911484 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
θ value	9.69798e-87 (rank : 13)	NC score	0.913030 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3C3_HUMAN
θ value	6.7944e-48 (rank : 14)	NC score	0.877287 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	4.40402e-47 (rank : 15)	NC score	0.876270 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PI4KA_HUMAN
θ value	3.06405e-32 (rank : 16)	NC score	0.829320 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PI4KB_MOUSE
θ value	2.68423e-28 (rank : 17)	NC score	0.795143 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KB_HUMAN
θ value	3.50572e-28 (rank : 18)	NC score	0.792846 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PRKDC_MOUSE
θ value	3.18553e-13 (rank : 19)	NC score	0.432340 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
θ value	2.0648e-12 (rank : 20)	NC score	0.425282 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

ATR_HUMAN
θ value	3.41135e-07 (rank : 21)	NC score	0.369032 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	7.59969e-07 (rank : 22)	NC score	0.367331 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_HUMAN
θ value	2.88788e-06 (rank : 23)	NC score	0.359790 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
θ value	1.87187e-05 (rank : 24)	NC score	0.349645 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

FRAP_HUMAN
θ value	0.000270298 (rank : 25)	NC score	0.405300 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	0.000270298 (rank : 26)	NC score	0.406464 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SMG1_HUMAN
θ value	0.000270298 (rank : 27)	NC score	0.296424 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	231	Shared Neighborhood Hits	28
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	0.000270298 (rank : 28)	NC score	0.298774 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	212	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

STAG1_HUMAN
θ value	0.365318 (rank : 29)	NC score	0.028345 (rank : 50)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WVM7, O00539	Gene names	STAG1, SA1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

STAG1_MOUSE
θ value	0.813845 (rank : 30)	NC score	0.025879 (rank : 51)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D3E6, O08982	Gene names	Stag1, Sa1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

HRX_HUMAN
θ value	1.06291 (rank : 31)	NC score	0.017565 (rank : 52)
Query Neighborhood Hits	41	Target Neighborhood Hits	825	Shared Neighborhood Hits	4
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

EFHA2_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.015618 (rank : 53)
Query Neighborhood Hits	41	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q86XE3, Q8IYZ3	Gene names	EFHA2
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member A2.

EFHA2_MOUSE
θ value	4.03905 (rank : 33)	NC score	0.015003 (rank : 54)
Query Neighborhood Hits	41	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CTY5	Gene names	Efha2
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member A2.

UT14C_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.011666 (rank : 55)
Query Neighborhood Hits	41	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TAP6, Q5FWG3, Q92555	Gene names	UTP14C, KIAA0266
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog C.

LRCH1_MOUSE
θ value	5.27518 (rank : 35)	NC score	0.004316 (rank : 57)
Query Neighborhood Hits	41	Target Neighborhood Hits	264	Shared Neighborhood Hits	3
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

ANFY1_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.003033 (rank : 58)
Query Neighborhood Hits	41	Target Neighborhood Hits	480	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_MOUSE
θ value	6.88961 (rank : 37)	NC score	0.002962 (rank : 59)
Query Neighborhood Hits	41	Target Neighborhood Hits	480	Shared Neighborhood Hits	4
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ITB2_MOUSE
θ value	6.88961 (rank : 38)	NC score	0.001678 (rank : 62)
Query Neighborhood Hits	41	Target Neighborhood Hits	326	Shared Neighborhood Hits	2
SwissProt Accessions	P11835, Q64482	Gene names	Itgb2
Domain Architecture
Description	Integrin beta-2 precursor (Cell surface adhesion glycoproteins LFA- 1/CR3/P150,95 subunit beta) (Complement receptor C3 subunit beta) (CD18 antigen).

LRCH1_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.006536 (rank : 56)
Query Neighborhood Hits	41	Target Neighborhood Hits	266	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2L9, Q7Z5F6, Q7Z5F7	Gene names	LRCH1, CHDC1, KIAA1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81).

DAAM2_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.002429 (rank : 61)
Query Neighborhood Hits	41	Target Neighborhood Hits	350	Shared Neighborhood Hits	2
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

NCOA2_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.002791 (rank : 60)
Query Neighborhood Hits	41	Target Neighborhood Hits	281	Shared Neighborhood Hits	2
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

DOC2B_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.050422 (rank : 49)
Query Neighborhood Hits	41	Target Neighborhood Hits	150	Shared Neighborhood Hits	5
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

FA62A_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.076610 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.085906 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RIMS1_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.071796 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	437	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.061257 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.061391 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	376	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS3_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.054327 (rank : 47)
Query Neighborhood Hits	41	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.053582 (rank : 48)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.087089 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.087088 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYTL1_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.065073 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL1_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.060716 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	314	Shared Neighborhood Hits	4
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.058302 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	248	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.056864 (rank : 46)
Query Neighborhood Hits	41	Target Neighborhood Hits	253	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL3_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.076264 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.059047 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.058692 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.063726 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	237	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.063007 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TRRAP_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.062453 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.062001 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

Hits sorted by NC score

PK3CG_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.999490 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CA_HUMAN
NC score	0.966483 (rank : 3)	θ value	1.32836e-152 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.966367 (rank : 4)	θ value	3.27187e-151 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CD_HUMAN
NC score	0.964303 (rank : 5)	θ value	5.41814e-138 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
NC score	0.963567 (rank : 6)	θ value	1.12976e-135 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_MOUSE
NC score	0.963447 (rank : 7)	θ value	3.06949e-141 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
NC score	0.963248 (rank : 8)	θ value	9.87422e-140 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

P3C2G_HUMAN
NC score	0.913030 (rank : 9)	θ value	9.69798e-87 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_MOUSE
NC score	0.911484 (rank : 10)	θ value	1.95407e-87 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3C3_HUMAN
NC score	0.877287 (rank : 11)	θ value	6.7944e-48 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.876270 (rank : 12)	θ value	4.40402e-47 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

P3C2A_MOUSE
NC score	0.837909 (rank : 13)	θ value	3.42535e-108 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.835304 (rank : 14)	θ value	6.90186e-109 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PI4KA_HUMAN
NC score	0.829320 (rank : 15)	θ value	3.06405e-32 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2B_HUMAN
NC score	0.812177 (rank : 16)	θ value	2.01279e-100 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PI4KB_MOUSE
NC score	0.795143 (rank : 17)	θ value	2.68423e-28 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KB_HUMAN
NC score	0.792846 (rank : 18)	θ value	3.50572e-28 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PRKDC_MOUSE
NC score	0.432340 (rank : 19)	θ value	3.18553e-13 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.425282 (rank : 20)	θ value	2.0648e-12 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

FRAP_MOUSE
NC score	0.406464 (rank : 21)	θ value	0.000270298 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.405300 (rank : 22)	θ value	0.000270298 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATR_HUMAN
NC score	0.369032 (rank : 23)	θ value	3.41135e-07 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.367331 (rank : 24)	θ value	7.59969e-07 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_HUMAN
NC score	0.359790 (rank : 25)	θ value	2.88788e-06 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
NC score	0.349645 (rank : 26)	θ value	1.87187e-05 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_MOUSE
NC score	0.298774 (rank : 27)	θ value	0.000270298 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	212	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.296424 (rank : 28)	θ value	0.000270298 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	231	Shared Neighborhood Hits	28
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

RIMS4_HUMAN
NC score	0.087089 (rank : 29)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	41	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
NC score	0.087088 (rank : 30)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	41	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

FA62A_MOUSE
NC score	0.085906 (rank : 31)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_HUMAN
NC score	0.076610 (rank : 32)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL3_MOUSE
NC score	0.076264 (rank : 33)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	41	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

RIMS1_HUMAN
NC score	0.071796 (rank : 34)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	437	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SYTL1_HUMAN
NC score	0.065073 (rank : 35)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	41	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL5_HUMAN
NC score	0.063726 (rank : 36)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	41	Target Neighborhood Hits	237	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
NC score	0.063007 (rank : 37)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	41	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TRRAP_HUMAN
NC score	0.062453 (rank : 38)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	41	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
NC score	0.062001 (rank : 39)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

RIMS2_MOUSE
NC score	0.061391 (rank : 40)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	41	Target Neighborhood Hits	376	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
NC score	0.061257 (rank : 41)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	41	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

SYTL1_MOUSE
NC score	0.060716 (rank : 42)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	41	Target Neighborhood Hits	314	Shared Neighborhood Hits	4
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL4_HUMAN
NC score	0.059047 (rank : 43)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	41	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
NC score	0.058692 (rank : 44)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	41	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL2_HUMAN
NC score	0.058302 (rank : 45)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	41	Target Neighborhood Hits	248	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
NC score	0.056864 (rank : 46)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	41	Target Neighborhood Hits	253	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

RIMS3_HUMAN
NC score	0.054327 (rank : 47)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	41	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
NC score	0.053582 (rank : 48)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

DOC2B_HUMAN
NC score	0.050422 (rank : 49)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	150	Shared Neighborhood Hits	5
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

STAG1_HUMAN
NC score	0.028345 (rank : 50)	θ value	0.365318 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WVM7, O00539	Gene names	STAG1, SA1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

STAG1_MOUSE
NC score	0.025879 (rank : 51)	θ value	0.813845 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D3E6, O08982	Gene names	Stag1, Sa1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

HRX_HUMAN
NC score	0.017565 (rank : 52)	θ value	1.06291 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	825	Shared Neighborhood Hits	4
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

EFHA2_HUMAN
NC score	0.015618 (rank : 53)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q86XE3, Q8IYZ3	Gene names	EFHA2
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member A2.

EFHA2_MOUSE
NC score	0.015003 (rank : 54)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CTY5	Gene names	Efha2
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member A2.

UT14C_HUMAN
NC score	0.011666 (rank : 55)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TAP6, Q5FWG3, Q92555	Gene names	UTP14C, KIAA0266
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog C.

LRCH1_HUMAN
NC score	0.006536 (rank : 56)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	266	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2L9, Q7Z5F6, Q7Z5F7	Gene names	LRCH1, CHDC1, KIAA1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81).

LRCH1_MOUSE
NC score	0.004316 (rank : 57)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	264	Shared Neighborhood Hits	3
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

ANFY1_HUMAN
NC score	0.003033 (rank : 58)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	480	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_MOUSE
NC score	0.002962 (rank : 59)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	480	Shared Neighborhood Hits	4
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

NCOA2_HUMAN
NC score	0.002791 (rank : 60)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	281	Shared Neighborhood Hits	2
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

DAAM2_HUMAN
NC score	0.002429 (rank : 61)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	350	Shared Neighborhood Hits	2
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

ITB2_MOUSE
NC score	0.001678 (rank : 62)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	326	Shared Neighborhood Hits	2
SwissProt Accessions	P11835, Q64482	Gene names	Itgb2
Domain Architecture
Description	Integrin beta-2 precursor (Cell surface adhesion glycoproteins LFA- 1/CR3/P150,95 subunit beta) (Complement receptor C3 subunit beta) (CD18 antigen).