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Network neighborhood for query Sequence : P3C2B_HUMAN

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P3C2B_HUMAN
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

P3C2A_HUMAN
θ value	0 (rank : 1)	NC score	0.979901 (rank : 3)
Query Neighborhood Hits	148	Target Neighborhood Hits	188	Shared Neighborhood Hits	109
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	0 (rank : 2)	NC score	0.980410 (rank : 2)
Query Neighborhood Hits	148	Target Neighborhood Hits	181	Shared Neighborhood Hits	111
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	148
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2G_HUMAN
θ value	0 (rank : 4)	NC score	0.887741 (rank : 5)
Query Neighborhood Hits	148	Target Neighborhood Hits	92	Shared Neighborhood Hits	70
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_MOUSE
θ value	0 (rank : 5)	NC score	0.901667 (rank : 4)
Query Neighborhood Hits	148	Target Neighborhood Hits	113	Shared Neighborhood Hits	88
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3CA_MOUSE
θ value	1.1019e-106 (rank : 6)	NC score	0.811608 (rank : 7)
Query Neighborhood Hits	148	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_HUMAN
θ value	1.43912e-106 (rank : 7)	NC score	0.811498 (rank : 9)
Query Neighborhood Hits	148	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CG_MOUSE
θ value	9.65309e-103 (rank : 8)	NC score	0.811600 (rank : 8)
Query Neighborhood Hits	148	Target Neighborhood Hits	43	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_HUMAN
θ value	2.01279e-100 (rank : 9)	NC score	0.812177 (rank : 6)
Query Neighborhood Hits	148	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CD_HUMAN
θ value	7.91507e-97 (rank : 10)	NC score	0.801978 (rank : 10)
Query Neighborhood Hits	148	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	6.7005e-96 (rank : 11)	NC score	0.801474 (rank : 11)
Query Neighborhood Hits	148	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_MOUSE
θ value	6.93392e-93 (rank : 12)	NC score	0.798980 (rank : 12)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
θ value	7.66637e-92 (rank : 13)	NC score	0.798749 (rank : 13)
Query Neighborhood Hits	148	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3C3_HUMAN
θ value	5.76516e-39 (rank : 14)	NC score	0.734868 (rank : 14)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	9.83387e-39 (rank : 15)	NC score	0.733676 (rank : 15)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PI4KA_HUMAN
θ value	2.86786e-30 (rank : 16)	NC score	0.709246 (rank : 16)
Query Neighborhood Hits	148	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PI4KB_HUMAN
θ value	6.18819e-25 (rank : 17)	NC score	0.666821 (rank : 18)
Query Neighborhood Hits	148	Target Neighborhood Hits	79	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	2.35151e-24 (rank : 18)	NC score	0.667948 (rank : 17)
Query Neighborhood Hits	148	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

FA62A_MOUSE
θ value	1.058e-16 (rank : 19)	NC score	0.477898 (rank : 35)
Query Neighborhood Hits	148	Target Neighborhood Hits	155	Shared Neighborhood Hits	83
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RP3A_HUMAN
θ value	8.95645e-16 (rank : 20)	NC score	0.490903 (rank : 30)
Query Neighborhood Hits	148	Target Neighborhood Hits	305	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
θ value	8.95645e-16 (rank : 21)	NC score	0.482855 (rank : 33)
Query Neighborhood Hits	148	Target Neighborhood Hits	510	Shared Neighborhood Hits	89
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT7_MOUSE
θ value	1.99529e-15 (rank : 22)	NC score	0.491055 (rank : 29)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

DOC2B_HUMAN
θ value	2.60593e-15 (rank : 23)	NC score	0.501817 (rank : 25)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	85
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

FA62A_HUMAN
θ value	4.44505e-15 (rank : 24)	NC score	0.466159 (rank : 47)
Query Neighborhood Hits	148	Target Neighborhood Hits	168	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

DOC2B_MOUSE
θ value	5.8054e-15 (rank : 25)	NC score	0.499783 (rank : 27)
Query Neighborhood Hits	148	Target Neighborhood Hits	169	Shared Neighborhood Hits	85
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_MOUSE
θ value	4.91457e-14 (rank : 26)	NC score	0.499707 (rank : 28)
Query Neighborhood Hits	148	Target Neighborhood Hits	140	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

SYTL5_HUMAN
θ value	8.38298e-14 (rank : 27)	NC score	0.504834 (rank : 23)
Query Neighborhood Hits	148	Target Neighborhood Hits	237	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

DOC2A_HUMAN
θ value	1.42992e-13 (rank : 28)	NC score	0.499957 (rank : 26)
Query Neighborhood Hits	148	Target Neighborhood Hits	144	Shared Neighborhood Hits	85
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

SYTL1_HUMAN
θ value	2.43908e-13 (rank : 29)	NC score	0.509347 (rank : 21)
Query Neighborhood Hits	148	Target Neighborhood Hits	227	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

RIMS1_HUMAN
θ value	5.43371e-13 (rank : 30)	NC score	0.449884 (rank : 60)
Query Neighborhood Hits	148	Target Neighborhood Hits	437	Shared Neighborhood Hits	78
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SYTL5_MOUSE
θ value	7.09661e-13 (rank : 31)	NC score	0.503658 (rank : 24)
Query Neighborhood Hits	148	Target Neighborhood Hits	154	Shared Neighborhood Hits	83
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

PCLO_HUMAN
θ value	1.2105e-12 (rank : 32)	NC score	0.343959 (rank : 69)
Query Neighborhood Hits	148	Target Neighborhood Hits	2046	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RIMS2_MOUSE
θ value	1.2105e-12 (rank : 33)	NC score	0.436756 (rank : 64)
Query Neighborhood Hits	148	Target Neighborhood Hits	376	Shared Neighborhood Hits	82
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
θ value	2.69671e-12 (rank : 34)	NC score	0.440344 (rank : 63)
Query Neighborhood Hits	148	Target Neighborhood Hits	342	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

SYT2_MOUSE
θ value	2.69671e-12 (rank : 35)	NC score	0.473809 (rank : 38)
Query Neighborhood Hits	148	Target Neighborhood Hits	143	Shared Neighborhood Hits	85
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT1_HUMAN
θ value	3.52202e-12 (rank : 36)	NC score	0.470609 (rank : 41)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	85
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	3.52202e-12 (rank : 37)	NC score	0.470599 (rank : 42)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	85
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT2_HUMAN
θ value	3.52202e-12 (rank : 38)	NC score	0.473778 (rank : 39)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYTL4_HUMAN
θ value	3.52202e-12 (rank : 39)	NC score	0.511221 (rank : 20)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	80
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	7.84624e-12 (rank : 40)	NC score	0.507899 (rank : 22)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

PCLO_MOUSE
θ value	1.33837e-11 (rank : 41)	NC score	0.323558 (rank : 76)
Query Neighborhood Hits	148	Target Neighborhood Hits	2275	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYTL1_MOUSE
θ value	1.33837e-11 (rank : 42)	NC score	0.488090 (rank : 31)
Query Neighborhood Hits	148	Target Neighborhood Hits	314	Shared Neighborhood Hits	78
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

RIMS4_MOUSE
θ value	2.98157e-11 (rank : 43)	NC score	0.449171 (rank : 61)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	72
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYT5_HUMAN
θ value	2.98157e-11 (rank : 44)	NC score	0.472588 (rank : 40)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	85
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

RIMS4_HUMAN
θ value	3.89403e-11 (rank : 45)	NC score	0.447776 (rank : 62)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYT7_HUMAN
θ value	6.64225e-11 (rank : 46)	NC score	0.476984 (rank : 37)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	84
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT3_HUMAN
θ value	1.9326e-10 (rank : 47)	NC score	0.467543 (rank : 44)
Query Neighborhood Hits	148	Target Neighborhood Hits	145	Shared Neighborhood Hits	84
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT6_MOUSE
θ value	2.52405e-10 (rank : 48)	NC score	0.466489 (rank : 46)
Query Neighborhood Hits	148	Target Neighborhood Hits	132	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_HUMAN
θ value	5.62301e-10 (rank : 49)	NC score	0.464695 (rank : 49)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	84
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

KPCG_MOUSE
θ value	7.34386e-10 (rank : 50)	NC score	0.135202 (rank : 115)
Query Neighborhood Hits	148	Target Neighborhood Hits	1123	Shared Neighborhood Hits	86
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

SYT3_MOUSE
θ value	7.34386e-10 (rank : 51)	NC score	0.465971 (rank : 48)
Query Neighborhood Hits	148	Target Neighborhood Hits	147	Shared Neighborhood Hits	84
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT4_HUMAN
θ value	7.34386e-10 (rank : 52)	NC score	0.463927 (rank : 50)
Query Neighborhood Hits	148	Target Neighborhood Hits	121	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

KPCA_HUMAN
θ value	9.59137e-10 (rank : 53)	NC score	0.128977 (rank : 117)
Query Neighborhood Hits	148	Target Neighborhood Hits	1070	Shared Neighborhood Hits	88
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYT11_HUMAN
θ value	9.59137e-10 (rank : 54)	NC score	0.462802 (rank : 53)
Query Neighborhood Hits	148	Target Neighborhood Hits	113	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	9.59137e-10 (rank : 55)	NC score	0.463335 (rank : 52)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT9_HUMAN
θ value	9.59137e-10 (rank : 56)	NC score	0.457142 (rank : 58)
Query Neighborhood Hits	148	Target Neighborhood Hits	144	Shared Neighborhood Hits	85
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYTL3_MOUSE
θ value	9.59137e-10 (rank : 57)	NC score	0.514011 (rank : 19)
Query Neighborhood Hits	148	Target Neighborhood Hits	110	Shared Neighborhood Hits	79
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

KPCG_HUMAN
θ value	3.64472e-09 (rank : 58)	NC score	0.134052 (rank : 116)
Query Neighborhood Hits	148	Target Neighborhood Hits	1126	Shared Neighborhood Hits	86
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

SYT10_MOUSE
θ value	3.64472e-09 (rank : 59)	NC score	0.458046 (rank : 56)
Query Neighborhood Hits	148	Target Neighborhood Hits	133	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT12_HUMAN
θ value	3.64472e-09 (rank : 60)	NC score	0.468822 (rank : 43)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	75
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT4_MOUSE
θ value	3.64472e-09 (rank : 61)	NC score	0.461500 (rank : 55)
Query Neighborhood Hits	148	Target Neighborhood Hits	123	Shared Neighborhood Hits	83
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

KPCA_MOUSE
θ value	8.11959e-09 (rank : 62)	NC score	0.125486 (rank : 118)
Query Neighborhood Hits	148	Target Neighborhood Hits	1067	Shared Neighborhood Hits	88
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYT12_MOUSE
θ value	8.11959e-09 (rank : 63)	NC score	0.467045 (rank : 45)
Query Neighborhood Hits	148	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT10_HUMAN
θ value	1.06045e-08 (rank : 64)	NC score	0.457612 (rank : 57)
Query Neighborhood Hits	148	Target Neighborhood Hits	134	Shared Neighborhood Hits	84
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT9_MOUSE
θ value	1.38499e-08 (rank : 65)	NC score	0.455174 (rank : 59)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

KPCB_HUMAN
θ value	6.87365e-08 (rank : 66)	NC score	0.124061 (rank : 119)
Query Neighborhood Hits	148	Target Neighborhood Hits	1121	Shared Neighborhood Hits	87
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	1.99992e-07 (rank : 67)	NC score	0.124037 (rank : 120)
Query Neighborhood Hits	148	Target Neighborhood Hits	1117	Shared Neighborhood Hits	86
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

RIMS3_HUMAN
θ value	3.41135e-07 (rank : 68)	NC score	0.380782 (rank : 67)
Query Neighborhood Hits	148	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SYT5_MOUSE
θ value	3.41135e-07 (rank : 69)	NC score	0.463769 (rank : 51)
Query Neighborhood Hits	148	Target Neighborhood Hits	140	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

RIMS3_MOUSE
θ value	9.92553e-07 (rank : 70)	NC score	0.374874 (rank : 68)
Query Neighborhood Hits	148	Target Neighborhood Hits	67	Shared Neighborhood Hits	66
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SYTL2_MOUSE
θ value	9.92553e-07 (rank : 71)	NC score	0.479542 (rank : 34)
Query Neighborhood Hits	148	Target Neighborhood Hits	253	Shared Neighborhood Hits	81
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_HUMAN
θ value	1.29631e-06 (rank : 72)	NC score	0.483614 (rank : 32)
Query Neighborhood Hits	148	Target Neighborhood Hits	248	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

FRAP_HUMAN
θ value	3.77169e-06 (rank : 73)	NC score	0.326164 (rank : 75)
Query Neighborhood Hits	148	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	3.77169e-06 (rank : 74)	NC score	0.327066 (rank : 73)
Query Neighborhood Hits	148	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

DOC2G_MOUSE
θ value	6.43352e-06 (rank : 75)	NC score	0.477394 (rank : 36)
Query Neighborhood Hits	148	Target Neighborhood Hits	125	Shared Neighborhood Hits	80
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT15_HUMAN
θ value	8.40245e-06 (rank : 76)	NC score	0.462011 (rank : 54)
Query Neighborhood Hits	148	Target Neighborhood Hits	112	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

RGS3_HUMAN
θ value	3.19293e-05 (rank : 77)	NC score	0.164436 (rank : 106)
Query Neighborhood Hits	148	Target Neighborhood Hits	1375	Shared Neighborhood Hits	84
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SYT15_MOUSE
θ value	3.19293e-05 (rank : 78)	NC score	0.433553 (rank : 65)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	81
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

NCF1_MOUSE
θ value	7.1131e-05 (rank : 79)	NC score	0.101927 (rank : 124)
Query Neighborhood Hits	148	Target Neighborhood Hits	198	Shared Neighborhood Hits	11
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF1_HUMAN
θ value	9.29e-05 (rank : 80)	NC score	0.109526 (rank : 122)
Query Neighborhood Hits	148	Target Neighborhood Hits	198	Shared Neighborhood Hits	13
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PRKDC_MOUSE
θ value	0.000121331 (rank : 81)	NC score	0.294297 (rank : 78)
Query Neighborhood Hits	148	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

SNX18_HUMAN
θ value	0.00020696 (rank : 82)	NC score	0.070351 (rank : 148)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0.00020696 (rank : 83)	NC score	0.066900 (rank : 151)
Query Neighborhood Hits	148	Target Neighborhood Hits	198	Shared Neighborhood Hits	13
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

RASA3_HUMAN
θ value	0.000461057 (rank : 84)	NC score	0.232470 (rank : 88)
Query Neighborhood Hits	148	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASL2_HUMAN
θ value	0.000461057 (rank : 85)	NC score	0.314357 (rank : 77)
Query Neighborhood Hits	148	Target Neighborhood Hits	161	Shared Neighborhood Hits	78
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RASA2_HUMAN
θ value	0.00102713 (rank : 86)	NC score	0.223684 (rank : 92)
Query Neighborhood Hits	148	Target Neighborhood Hits	157	Shared Neighborhood Hits	73
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

PRKDC_HUMAN
θ value	0.00134147 (rank : 87)	NC score	0.285459 (rank : 79)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

SYT8_MOUSE
θ value	0.00175202 (rank : 88)	NC score	0.427121 (rank : 66)
Query Neighborhood Hits	148	Target Neighborhood Hits	94	Shared Neighborhood Hits	75
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

RASA2_MOUSE
θ value	0.00228821 (rank : 89)	NC score	0.227566 (rank : 91)
Query Neighborhood Hits	148	Target Neighborhood Hits	159	Shared Neighborhood Hits	73
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

K0528_HUMAN
θ value	0.00509761 (rank : 90)	NC score	0.258516 (rank : 80)
Query Neighborhood Hits	148	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	0.00509761 (rank : 91)	NC score	0.258404 (rank : 81)
Query Neighborhood Hits	148	Target Neighborhood Hits	102	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

SMG1_HUMAN
θ value	0.00665767 (rank : 92)	NC score	0.209984 (rank : 95)
Query Neighborhood Hits	148	Target Neighborhood Hits	231	Shared Neighborhood Hits	29
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	0.00665767 (rank : 93)	NC score	0.211755 (rank : 94)
Query Neighborhood Hits	148	Target Neighborhood Hits	212	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

NCF4_MOUSE
θ value	0.0148317 (rank : 94)	NC score	0.052410 (rank : 169)
Query Neighborhood Hits	148	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEDD4_HUMAN
θ value	0.0148317 (rank : 95)	NC score	0.163516 (rank : 107)
Query Neighborhood Hits	148	Target Neighborhood Hits	214	Shared Neighborhood Hits	78
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

SNX22_HUMAN
θ value	0.0148317 (rank : 96)	NC score	0.063674 (rank : 154)
Query Neighborhood Hits	148	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q96L94, Q9H844	Gene names	SNX22
Domain Architecture
Description	Sorting nexin-22.

ATR_MOUSE
θ value	0.0193708 (rank : 97)	NC score	0.255631 (rank : 83)
Query Neighborhood Hits	148	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

SNX16_MOUSE
θ value	0.0193708 (rank : 98)	NC score	0.088090 (rank : 133)
Query Neighborhood Hits	148	Target Neighborhood Hits	82	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C080	Gene names	Snx16
Domain Architecture	No domain graphic available
Description	Sorting nexin-16.

ATR_HUMAN
θ value	0.0252991 (rank : 99)	NC score	0.255712 (rank : 82)
Query Neighborhood Hits	148	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

NEDD4_MOUSE
θ value	0.0330416 (rank : 100)	NC score	0.153763 (rank : 111)
Query Neighborhood Hits	148	Target Neighborhood Hits	212	Shared Neighborhood Hits	77
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

DYSF_HUMAN
θ value	0.0431538 (rank : 101)	NC score	0.197320 (rank : 96)
Query Neighborhood Hits	148	Target Neighborhood Hits	170	Shared Neighborhood Hits	80
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

NCF4_HUMAN
θ value	0.0563607 (rank : 102)	NC score	0.063844 (rank : 153)
Query Neighborhood Hits	148	Target Neighborhood Hits	161	Shared Neighborhood Hits	18
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DYSF_MOUSE
θ value	0.0961366 (rank : 103)	NC score	0.191720 (rank : 97)
Query Neighborhood Hits	148	Target Neighborhood Hits	162	Shared Neighborhood Hits	78
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

SGK3_MOUSE
θ value	0.0961366 (rank : 104)	NC score	0.027701 (rank : 172)
Query Neighborhood Hits	148	Target Neighborhood Hits	882	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

TRPV4_HUMAN
θ value	0.0961366 (rank : 105)	NC score	0.013569 (rank : 178)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

SGK3_HUMAN
θ value	0.125558 (rank : 106)	NC score	0.027630 (rank : 174)
Query Neighborhood Hits	148	Target Neighborhood Hits	877	Shared Neighborhood Hits	24
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SYT13_MOUSE
θ value	0.125558 (rank : 107)	NC score	0.341954 (rank : 70)
Query Neighborhood Hits	148	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

NED4L_HUMAN
θ value	0.163984 (rank : 108)	NC score	0.176693 (rank : 99)
Query Neighborhood Hits	148	Target Neighborhood Hits	238	Shared Neighborhood Hits	81
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	0.163984 (rank : 109)	NC score	0.173539 (rank : 100)
Query Neighborhood Hits	148	Target Neighborhood Hits	231	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

RASA1_HUMAN
θ value	0.21417 (rank : 110)	NC score	0.043704 (rank : 171)
Query Neighborhood Hits	148	Target Neighborhood Hits	258	Shared Neighborhood Hits	24
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SNX16_HUMAN
θ value	0.279714 (rank : 111)	NC score	0.085121 (rank : 134)
Query Neighborhood Hits	148	Target Neighborhood Hits	110	Shared Neighborhood Hits	17
SwissProt Accessions	P57768, Q8N4U3	Gene names	SNX16
Domain Architecture
Description	Sorting nexin-16.

SYT14_HUMAN
θ value	0.62314 (rank : 112)	NC score	0.327107 (rank : 72)
Query Neighborhood Hits	148	Target Neighborhood Hits	81	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

HRX_HUMAN
θ value	0.813845 (rank : 113)	NC score	0.019297 (rank : 176)
Query Neighborhood Hits	148	Target Neighborhood Hits	825	Shared Neighborhood Hits	16
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

KKCC2_MOUSE
θ value	0.813845 (rank : 114)	NC score	0.010120 (rank : 186)
Query Neighborhood Hits	148	Target Neighborhood Hits	855	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

NOXO1_MOUSE
θ value	0.813845 (rank : 115)	NC score	0.054649 (rank : 166)
Query Neighborhood Hits	148	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SNX24_HUMAN
θ value	0.813845 (rank : 116)	NC score	0.054762 (rank : 165)
Query Neighborhood Hits	148	Target Neighborhood Hits	42	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y343, Q6UY33	Gene names	SNX24
Domain Architecture
Description	Sorting nexin-24.

SNX24_MOUSE
θ value	0.813845 (rank : 117)	NC score	0.054170 (rank : 167)
Query Neighborhood Hits	148	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CRB0	Gene names	Snx24
Domain Architecture	No domain graphic available
Description	Sorting nexin-24.

ATM_HUMAN
θ value	1.06291 (rank : 118)	NC score	0.232768 (rank : 87)
Query Neighborhood Hits	148	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

MUCDL_HUMAN
θ value	1.06291 (rank : 119)	NC score	0.014690 (rank : 177)
Query Neighborhood Hits	148	Target Neighborhood Hits	777	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

UN13A_HUMAN
θ value	1.06291 (rank : 120)	NC score	0.161566 (rank : 108)
Query Neighborhood Hits	148	Target Neighborhood Hits	285	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

SYT14_MOUSE
θ value	1.38821 (rank : 121)	NC score	0.326825 (rank : 74)
Query Neighborhood Hits	148	Target Neighborhood Hits	82	Shared Neighborhood Hits	58
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

ATF6B_HUMAN
θ value	1.81305 (rank : 122)	NC score	0.013031 (rank : 180)
Query Neighborhood Hits	148	Target Neighborhood Hits	122	Shared Neighborhood Hits	5
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

HHIP_MOUSE
θ value	1.81305 (rank : 123)	NC score	0.011834 (rank : 182)
Query Neighborhood Hits	148	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TN16, Q8C0B0, Q9WU59	Gene names	Hhip, Hip
Domain Architecture	No domain graphic available
Description	Hedgehog-interacting protein precursor (HHIP) (HIP).

MAP1A_HUMAN
θ value	1.81305 (rank : 124)	NC score	0.002866 (rank : 190)
Query Neighborhood Hits	148	Target Neighborhood Hits	1626	Shared Neighborhood Hits	13
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

GAB1_MOUSE
θ value	2.36792 (rank : 125)	NC score	0.011424 (rank : 184)
Query Neighborhood Hits	148	Target Neighborhood Hits	233	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

HHIP_HUMAN
θ value	2.36792 (rank : 126)	NC score	0.010481 (rank : 185)
Query Neighborhood Hits	148	Target Neighborhood Hits	249	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QV1, Q6PK09, Q8NCI7, Q9BXK3, Q9H1J4, Q9H7E7	Gene names	HHIP, HIP
Domain Architecture	No domain graphic available
Description	Hedgehog-interacting protein precursor (HHIP) (HIP).

IQEC2_HUMAN
θ value	2.36792 (rank : 127)	NC score	0.011821 (rank : 183)
Query Neighborhood Hits	148	Target Neighborhood Hits	403	Shared Neighborhood Hits	9
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	2.36792 (rank : 128)	NC score	0.012171 (rank : 181)
Query Neighborhood Hits	148	Target Neighborhood Hits	417	Shared Neighborhood Hits	10
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

OTOF_MOUSE
θ value	4.03905 (rank : 129)	NC score	0.151831 (rank : 113)
Query Neighborhood Hits	148	Target Neighborhood Hits	196	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

WWC1_MOUSE
θ value	4.03905 (rank : 130)	NC score	0.066312 (rank : 152)
Query Neighborhood Hits	148	Target Neighborhood Hits	290	Shared Neighborhood Hits	31
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

ABCAD_MOUSE
θ value	5.27518 (rank : 131)	NC score	0.001816 (rank : 192)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SSE9, Q80T20, Q8BHZ2, Q8CB91	Gene names	Abca13
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 13.

ATM_MOUSE
θ value	5.27518 (rank : 132)	NC score	0.223266 (rank : 93)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

OTOF_HUMAN
θ value	5.27518 (rank : 133)	NC score	0.153717 (rank : 112)
Query Neighborhood Hits	148	Target Neighborhood Hits	168	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

WDR33_HUMAN
θ value	5.27518 (rank : 134)	NC score	0.000739 (rank : 193)
Query Neighborhood Hits	148	Target Neighborhood Hits	638	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

ABCG4_HUMAN
θ value	6.88961 (rank : 135)	NC score	0.002345 (rank : 191)
Query Neighborhood Hits	148	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H172	Gene names	ABCG4, WHITE2
Domain Architecture
Description	ATP-binding cassette sub-family G member 4.

KMHN1_HUMAN
θ value	6.88961 (rank : 136)	NC score	-0.003384 (rank : 196)
Query Neighborhood Hits	148	Target Neighborhood Hits	950	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

LPIN1_HUMAN
θ value	6.88961 (rank : 137)	NC score	0.004210 (rank : 189)
Query Neighborhood Hits	148	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q14693	Gene names	LPIN1, KIAA0188
Domain Architecture
Description	Lipin-1.

OPSG_MOUSE
θ value	6.88961 (rank : 138)	NC score	-0.004917 (rank : 197)
Query Neighborhood Hits	148	Target Neighborhood Hits	717	Shared Neighborhood Hits	2
SwissProt Accessions	O35599, Q548Z4	Gene names	Opn1mw, Gcp
Domain Architecture
Description	Green-sensitive opsin (Green cone photoreceptor pigment) (Medium wavelength-sensitive cone opsin) (M opsin).

SNX14_MOUSE
θ value	6.88961 (rank : 139)	NC score	0.026517 (rank : 175)
Query Neighborhood Hits	148	Target Neighborhood Hits	75	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

TXLNA_MOUSE
θ value	6.88961 (rank : 140)	NC score	0.000273 (rank : 194)
Query Neighborhood Hits	148	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

AIOL_HUMAN
θ value	8.99809 (rank : 141)	NC score	-0.006912 (rank : 198)
Query Neighborhood Hits	148	Target Neighborhood Hits	739	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKT9, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3	Gene names	IKZF3, ZNFN1A3
Domain Architecture	No domain graphic available
Description	Zinc finger protein Aiolos (IKAROS family zinc finger protein 3).

CAC1B_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.000217 (rank : 195)
Query Neighborhood Hits	148	Target Neighborhood Hits	257	Shared Neighborhood Hits	6
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

DIDO1_HUMAN
θ value	8.99809 (rank : 143)	NC score	0.008967 (rank : 188)
Query Neighborhood Hits	148	Target Neighborhood Hits	960	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

FYB_HUMAN
θ value	8.99809 (rank : 144)	NC score	0.013230 (rank : 179)
Query Neighborhood Hits	148	Target Neighborhood Hits	379	Shared Neighborhood Hits	8
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GON4L_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.010008 (rank : 187)
Query Neighborhood Hits	148	Target Neighborhood Hits	555	Shared Neighborhood Hits	13
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

PA24A_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.094229 (rank : 129)
Query Neighborhood Hits	148	Target Neighborhood Hits	88	Shared Neighborhood Hits	61
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

SNX14_HUMAN
θ value	8.99809 (rank : 147)	NC score	0.027665 (rank : 173)
Query Neighborhood Hits	148	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

UN13B_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.166558 (rank : 105)
Query Neighborhood Hits	148	Target Neighborhood Hits	217	Shared Neighborhood Hits	66
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

BAIP3_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.229865 (rank : 89)
Query Neighborhood Hits	148	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.227986 (rank : 90)
Query Neighborhood Hits	148	Target Neighborhood Hits	112	Shared Neighborhood Hits	66
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

CPNE1_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.070196 (rank : 149)
Query Neighborhood Hits	148	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE1_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.084898 (rank : 135)
Query Neighborhood Hits	148	Target Neighborhood Hits	83	Shared Neighborhood Hits	50
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE2_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.084474 (rank : 137)
Query Neighborhood Hits	148	Target Neighborhood Hits	75	Shared Neighborhood Hits	46
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE2_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.084495 (rank : 136)
Query Neighborhood Hits	148	Target Neighborhood Hits	82	Shared Neighborhood Hits	49
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE3_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.097106 (rank : 127)
Query Neighborhood Hits	148	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE3_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.097265 (rank : 126)
Query Neighborhood Hits	148	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE4_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.052457 (rank : 168)
Query Neighborhood Hits	148	Target Neighborhood Hits	70	Shared Neighborhood Hits	43
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.051008 (rank : 170)
Query Neighborhood Hits	148	Target Neighborhood Hits	67	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CPNE5_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.088477 (rank : 132)
Query Neighborhood Hits	148	Target Neighborhood Hits	88	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.088752 (rank : 131)
Query Neighborhood Hits	148	Target Neighborhood Hits	86	Shared Neighborhood Hits	49
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE6_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.062733 (rank : 156)
Query Neighborhood Hits	148	Target Neighborhood Hits	85	Shared Neighborhood Hits	48
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.059058 (rank : 158)
Query Neighborhood Hits	148	Target Neighborhood Hits	87	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE7_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.075413 (rank : 143)
Query Neighborhood Hits	148	Target Neighborhood Hits	92	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

CPNE8_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.082802 (rank : 139)
Query Neighborhood Hits	148	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE8_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.080832 (rank : 141)
Query Neighborhood Hits	148	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

ITSN1_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.057959 (rank : 162)
Query Neighborhood Hits	148	Target Neighborhood Hits	1757	Shared Neighborhood Hits	80
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.058354 (rank : 161)
Query Neighborhood Hits	148	Target Neighborhood Hits	1669	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.083119 (rank : 138)
Query Neighborhood Hits	148	Target Neighborhood Hits	1173	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.074939 (rank : 144)
Query Neighborhood Hits	148	Target Neighborhood Hits	1371	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MELPH_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.069092 (rank : 150)
Query Neighborhood Hits	148	Target Neighborhood Hits	145	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

MELPH_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.070699 (rank : 147)
Query Neighborhood Hits	148	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MYOF_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.179029 (rank : 98)
Query Neighborhood Hits	148	Target Neighborhood Hits	147	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

MYRIP_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.076976 (rank : 142)
Query Neighborhood Hits	148	Target Neighborhood Hits	269	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

MYRIP_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.080903 (rank : 140)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

PA24A_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.099865 (rank : 125)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	60
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24B_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.091774 (rank : 130)
Query Neighborhood Hits	148	Target Neighborhood Hits	89	Shared Neighborhood Hits	52
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24B_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.117004 (rank : 121)
Query Neighborhood Hits	148	Target Neighborhood Hits	102	Shared Neighborhood Hits	55
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24D_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.135471 (rank : 114)
Query Neighborhood Hits	148	Target Neighborhood Hits	97	Shared Neighborhood Hits	61
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PA24D_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.160090 (rank : 109)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	64
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PA24E_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.094751 (rank : 128)
Query Neighborhood Hits	148	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24E_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.107512 (rank : 123)
Query Neighborhood Hits	148	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24F_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.056152 (rank : 164)
Query Neighborhood Hits	148	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PA24F_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.070860 (rank : 146)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	49
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PLCD1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.071500 (rank : 145)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	42
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

RASA3_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.166787 (rank : 104)
Query Neighborhood Hits	148	Target Neighborhood Hits	144	Shared Neighborhood Hits	65
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASL1_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.245182 (rank : 84)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	67
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.237910 (rank : 86)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RFIP1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.057415 (rank : 163)
Query Neighborhood Hits	148	Target Neighborhood Hits	236	Shared Neighborhood Hits	31
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RFIP1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.062919 (rank : 155)
Query Neighborhood Hits	148	Target Neighborhood Hits	152	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RFIP2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.154254 (rank : 110)
Query Neighborhood Hits	148	Target Neighborhood Hits	97	Shared Neighborhood Hits	59
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

SMUF1_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.059421 (rank : 157)
Query Neighborhood Hits	148	Target Neighborhood Hits	135	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.058453 (rank : 159)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.058413 (rank : 160)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SYT13_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.335361 (rank : 71)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	63
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

TAC2N_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.171345 (rank : 101)
Query Neighborhood Hits	148	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.170709 (rank : 102)
Query Neighborhood Hits	148	Target Neighborhood Hits	43	Shared Neighborhood Hits	36
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

UN13B_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.168270 (rank : 103)
Query Neighborhood Hits	148	Target Neighborhood Hits	210	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13D_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.239687 (rank : 85)
Query Neighborhood Hits	148	Target Neighborhood Hits	117	Shared Neighborhood Hits	70
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

Hits sorted by NC score

P3C2B_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	148
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2A_MOUSE
NC score	0.980410 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	148	Target Neighborhood Hits	181	Shared Neighborhood Hits	111
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.979901 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	148	Target Neighborhood Hits	188	Shared Neighborhood Hits	109
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2G_MOUSE
NC score	0.901667 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	148	Target Neighborhood Hits	113	Shared Neighborhood Hits	88
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
NC score	0.887741 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	148	Target Neighborhood Hits	92	Shared Neighborhood Hits	70
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3CG_HUMAN
NC score	0.812177 (rank : 6)	θ value	2.01279e-100 (rank : 9)
Query Neighborhood Hits	148	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CA_MOUSE
NC score	0.811608 (rank : 7)	θ value	1.1019e-106 (rank : 6)
Query Neighborhood Hits	148	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CG_MOUSE
NC score	0.811600 (rank : 8)	θ value	9.65309e-103 (rank : 8)
Query Neighborhood Hits	148	Target Neighborhood Hits	43	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CA_HUMAN
NC score	0.811498 (rank : 9)	θ value	1.43912e-106 (rank : 7)
Query Neighborhood Hits	148	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CD_HUMAN
NC score	0.801978 (rank : 10)	θ value	7.91507e-97 (rank : 10)
Query Neighborhood Hits	148	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
NC score	0.801474 (rank : 11)	θ value	6.7005e-96 (rank : 11)
Query Neighborhood Hits	148	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_MOUSE
NC score	0.798980 (rank : 12)	θ value	6.93392e-93 (rank : 12)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
NC score	0.798749 (rank : 13)	θ value	7.66637e-92 (rank : 13)
Query Neighborhood Hits	148	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3C3_HUMAN
NC score	0.734868 (rank : 14)	θ value	5.76516e-39 (rank : 14)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.733676 (rank : 15)	θ value	9.83387e-39 (rank : 15)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PI4KA_HUMAN
NC score	0.709246 (rank : 16)	θ value	2.86786e-30 (rank : 16)
Query Neighborhood Hits	148	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PI4KB_MOUSE
NC score	0.667948 (rank : 17)	θ value	2.35151e-24 (rank : 18)
Query Neighborhood Hits	148	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KB_HUMAN
NC score	0.666821 (rank : 18)	θ value	6.18819e-25 (rank : 17)
Query Neighborhood Hits	148	Target Neighborhood Hits	79	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

SYTL3_MOUSE
NC score	0.514011 (rank : 19)	θ value	9.59137e-10 (rank : 57)
Query Neighborhood Hits	148	Target Neighborhood Hits	110	Shared Neighborhood Hits	79
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
NC score	0.511221 (rank : 20)	θ value	3.52202e-12 (rank : 39)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	80
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL1_HUMAN
NC score	0.509347 (rank : 21)	θ value	2.43908e-13 (rank : 29)
Query Neighborhood Hits	148	Target Neighborhood Hits	227	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL4_MOUSE
NC score	0.507899 (rank : 22)	θ value	7.84624e-12 (rank : 40)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
NC score	0.504834 (rank : 23)	θ value	8.38298e-14 (rank : 27)
Query Neighborhood Hits	148	Target Neighborhood Hits	237	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
NC score	0.503658 (rank : 24)	θ value	7.09661e-13 (rank : 31)
Query Neighborhood Hits	148	Target Neighborhood Hits	154	Shared Neighborhood Hits	83
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

DOC2B_HUMAN
NC score	0.501817 (rank : 25)	θ value	2.60593e-15 (rank : 23)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	85
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_HUMAN
NC score	0.499957 (rank : 26)	θ value	1.42992e-13 (rank : 28)
Query Neighborhood Hits	148	Target Neighborhood Hits	144	Shared Neighborhood Hits	85
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2B_MOUSE
NC score	0.499783 (rank : 27)	θ value	5.8054e-15 (rank : 25)
Query Neighborhood Hits	148	Target Neighborhood Hits	169	Shared Neighborhood Hits	85
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_MOUSE
NC score	0.499707 (rank : 28)	θ value	4.91457e-14 (rank : 26)
Query Neighborhood Hits	148	Target Neighborhood Hits	140	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

SYT7_MOUSE
NC score	0.491055 (rank : 29)	θ value	1.99529e-15 (rank : 22)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

RP3A_HUMAN
NC score	0.490903 (rank : 30)	θ value	8.95645e-16 (rank : 20)
Query Neighborhood Hits	148	Target Neighborhood Hits	305	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYTL1_MOUSE
NC score	0.488090 (rank : 31)	θ value	1.33837e-11 (rank : 42)
Query Neighborhood Hits	148	Target Neighborhood Hits	314	Shared Neighborhood Hits	78
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
NC score	0.483614 (rank : 32)	θ value	1.29631e-06 (rank : 72)
Query Neighborhood Hits	148	Target Neighborhood Hits	248	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

RP3A_MOUSE
NC score	0.482855 (rank : 33)	θ value	8.95645e-16 (rank : 21)
Query Neighborhood Hits	148	Target Neighborhood Hits	510	Shared Neighborhood Hits	89
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYTL2_MOUSE
NC score	0.479542 (rank : 34)	θ value	9.92553e-07 (rank : 71)
Query Neighborhood Hits	148	Target Neighborhood Hits	253	Shared Neighborhood Hits	81
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

FA62A_MOUSE
NC score	0.477898 (rank : 35)	θ value	1.058e-16 (rank : 19)
Query Neighborhood Hits	148	Target Neighborhood Hits	155	Shared Neighborhood Hits	83
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

DOC2G_MOUSE
NC score	0.477394 (rank : 36)	θ value	6.43352e-06 (rank : 75)
Query Neighborhood Hits	148	Target Neighborhood Hits	125	Shared Neighborhood Hits	80
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT7_HUMAN
NC score	0.476984 (rank : 37)	θ value	6.64225e-11 (rank : 46)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	84
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT2_MOUSE
NC score	0.473809 (rank : 38)	θ value	2.69671e-12 (rank : 35)
Query Neighborhood Hits	148	Target Neighborhood Hits	143	Shared Neighborhood Hits	85
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
NC score	0.473778 (rank : 39)	θ value	3.52202e-12 (rank : 38)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_HUMAN
NC score	0.472588 (rank : 40)	θ value	2.98157e-11 (rank : 44)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	85
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT1_HUMAN
NC score	0.470609 (rank : 41)	θ value	3.52202e-12 (rank : 36)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	85
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.470599 (rank : 42)	θ value	3.52202e-12 (rank : 37)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	85
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT12_HUMAN
NC score	0.468822 (rank : 43)	θ value	3.64472e-09 (rank : 60)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	75
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT3_HUMAN
NC score	0.467543 (rank : 44)	θ value	1.9326e-10 (rank : 47)
Query Neighborhood Hits	148	Target Neighborhood Hits	145	Shared Neighborhood Hits	84
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT12_MOUSE
NC score	0.467045 (rank : 45)	θ value	8.11959e-09 (rank : 63)
Query Neighborhood Hits	148	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT6_MOUSE
NC score	0.466489 (rank : 46)	θ value	2.52405e-10 (rank : 48)
Query Neighborhood Hits	148	Target Neighborhood Hits	132	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

FA62A_HUMAN
NC score	0.466159 (rank : 47)	θ value	4.44505e-15 (rank : 24)
Query Neighborhood Hits	148	Target Neighborhood Hits	168	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT3_MOUSE
NC score	0.465971 (rank : 48)	θ value	7.34386e-10 (rank : 51)
Query Neighborhood Hits	148	Target Neighborhood Hits	147	Shared Neighborhood Hits	84
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT6_HUMAN
NC score	0.464695 (rank : 49)	θ value	5.62301e-10 (rank : 49)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	84
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT4_HUMAN
NC score	0.463927 (rank : 50)	θ value	7.34386e-10 (rank : 52)
Query Neighborhood Hits	148	Target Neighborhood Hits	121	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT5_MOUSE
NC score	0.463769 (rank : 51)	θ value	3.41135e-07 (rank : 69)
Query Neighborhood Hits	148	Target Neighborhood Hits	140	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT11_MOUSE
NC score	0.463335 (rank : 52)	θ value	9.59137e-10 (rank : 55)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
NC score	0.462802 (rank : 53)	θ value	9.59137e-10 (rank : 54)
Query Neighborhood Hits	148	Target Neighborhood Hits	113	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT15_HUMAN
NC score	0.462011 (rank : 54)	θ value	8.40245e-06 (rank : 76)
Query Neighborhood Hits	148	Target Neighborhood Hits	112	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT4_MOUSE
NC score	0.461500 (rank : 55)	θ value	3.64472e-09 (rank : 61)
Query Neighborhood Hits	148	Target Neighborhood Hits	123	Shared Neighborhood Hits	83
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT10_MOUSE
NC score	0.458046 (rank : 56)	θ value	3.64472e-09 (rank : 59)
Query Neighborhood Hits	148	Target Neighborhood Hits	133	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_HUMAN
NC score	0.457612 (rank : 57)	θ value	1.06045e-08 (rank : 64)
Query Neighborhood Hits	148	Target Neighborhood Hits	134	Shared Neighborhood Hits	84
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT9_HUMAN
NC score	0.457142 (rank : 58)	θ value	9.59137e-10 (rank : 56)
Query Neighborhood Hits	148	Target Neighborhood Hits	144	Shared Neighborhood Hits	85
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
NC score	0.455174 (rank : 59)	θ value	1.38499e-08 (rank : 65)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

RIMS1_HUMAN
NC score	0.449884 (rank : 60)	θ value	5.43371e-13 (rank : 30)
Query Neighborhood Hits	148	Target Neighborhood Hits	437	Shared Neighborhood Hits	78
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS4_MOUSE
NC score	0.449171 (rank : 61)	θ value	2.98157e-11 (rank : 43)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	72
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.447776 (rank : 62)	θ value	3.89403e-11 (rank : 45)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS2_HUMAN
NC score	0.440344 (rank : 63)	θ value	2.69671e-12 (rank : 34)
Query Neighborhood Hits	148	Target Neighborhood Hits	342	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.436756 (rank : 64)	θ value	1.2105e-12 (rank : 33)
Query Neighborhood Hits	148	Target Neighborhood Hits	376	Shared Neighborhood Hits	82
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SYT15_MOUSE
NC score	0.433553 (rank : 65)	θ value	3.19293e-05 (rank : 78)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	81
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYT8_MOUSE
NC score	0.427121 (rank : 66)	θ value	0.00175202 (rank : 88)
Query Neighborhood Hits	148	Target Neighborhood Hits	94	Shared Neighborhood Hits	75
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

RIMS3_HUMAN
NC score	0.380782 (rank : 67)	θ value	3.41135e-07 (rank : 68)
Query Neighborhood Hits	148	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
NC score	0.374874 (rank : 68)	θ value	9.92553e-07 (rank : 70)
Query Neighborhood Hits	148	Target Neighborhood Hits	67	Shared Neighborhood Hits	66
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

PCLO_HUMAN
NC score	0.343959 (rank : 69)	θ value	1.2105e-12 (rank : 32)
Query Neighborhood Hits	148	Target Neighborhood Hits	2046	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYT13_MOUSE
NC score	0.341954 (rank : 70)	θ value	0.125558 (rank : 107)
Query Neighborhood Hits	148	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_HUMAN
NC score	0.335361 (rank : 71)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	63
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT14_HUMAN
NC score	0.327107 (rank : 72)	θ value	0.62314 (rank : 112)
Query Neighborhood Hits	148	Target Neighborhood Hits	81	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

FRAP_MOUSE
NC score	0.327066 (rank : 73)	θ value	3.77169e-06 (rank : 74)
Query Neighborhood Hits	148	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SYT14_MOUSE
NC score	0.326825 (rank : 74)	θ value	1.38821 (rank : 121)
Query Neighborhood Hits	148	Target Neighborhood Hits	82	Shared Neighborhood Hits	58
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

FRAP_HUMAN
NC score	0.326164 (rank : 75)	θ value	3.77169e-06 (rank : 73)
Query Neighborhood Hits	148	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

PCLO_MOUSE
NC score	0.323558 (rank : 76)	θ value	1.33837e-11 (rank : 41)
Query Neighborhood Hits	148	Target Neighborhood Hits	2275	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RASL2_HUMAN
NC score	0.314357 (rank : 77)	θ value	0.000461057 (rank : 85)
Query Neighborhood Hits	148	Target Neighborhood Hits	161	Shared Neighborhood Hits	78
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

PRKDC_MOUSE
NC score	0.294297 (rank : 78)	θ value	0.000121331 (rank : 81)
Query Neighborhood Hits	148	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.285459 (rank : 79)	θ value	0.00134147 (rank : 87)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

K0528_HUMAN
NC score	0.258516 (rank : 80)	θ value	0.00509761 (rank : 90)
Query Neighborhood Hits	148	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
NC score	0.258404 (rank : 81)	θ value	0.00509761 (rank : 91)
Query Neighborhood Hits	148	Target Neighborhood Hits	102	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

ATR_HUMAN
NC score	0.255712 (rank : 82)	θ value	0.0252991 (rank : 99)
Query Neighborhood Hits	148	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.255631 (rank : 83)	θ value	0.0193708 (rank : 97)
Query Neighborhood Hits	148	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

RASL1_HUMAN
NC score	0.245182 (rank : 84)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	67
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

UN13D_HUMAN
NC score	0.239687 (rank : 85)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	148	Target Neighborhood Hits	117	Shared Neighborhood Hits	70
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

RASL1_MOUSE
NC score	0.237910 (rank : 86)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

ATM_HUMAN
NC score	0.232768 (rank : 87)	θ value	1.06291 (rank : 118)
Query Neighborhood Hits	148	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

RASA3_HUMAN
NC score	0.232470 (rank : 88)	θ value	0.000461057 (rank : 84)
Query Neighborhood Hits	148	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

BAIP3_HUMAN
NC score	0.229865 (rank : 89)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	148	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
NC score	0.227986 (rank : 90)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	148	Target Neighborhood Hits	112	Shared Neighborhood Hits	66
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

RASA2_MOUSE
NC score	0.227566 (rank : 91)	θ value	0.00228821 (rank : 89)
Query Neighborhood Hits	148	Target Neighborhood Hits	159	Shared Neighborhood Hits	73
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_HUMAN
NC score	0.223684 (rank : 92)	θ value	0.00102713 (rank : 86)
Query Neighborhood Hits	148	Target Neighborhood Hits	157	Shared Neighborhood Hits	73
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

ATM_MOUSE
NC score	0.223266 (rank : 93)	θ value	5.27518 (rank : 132)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_MOUSE
NC score	0.211755 (rank : 94)	θ value	0.00665767 (rank : 93)
Query Neighborhood Hits	148	Target Neighborhood Hits	212	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.209984 (rank : 95)	θ value	0.00665767 (rank : 92)
Query Neighborhood Hits	148	Target Neighborhood Hits	231	Shared Neighborhood Hits	29
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

DYSF_HUMAN
NC score	0.197320 (rank : 96)	θ value	0.0431538 (rank : 101)
Query Neighborhood Hits	148	Target Neighborhood Hits	170	Shared Neighborhood Hits	80
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

DYSF_MOUSE
NC score	0.191720 (rank : 97)	θ value	0.0961366 (rank : 103)
Query Neighborhood Hits	148	Target Neighborhood Hits	162	Shared Neighborhood Hits	78
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

MYOF_HUMAN
NC score	0.179029 (rank : 98)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	148	Target Neighborhood Hits	147	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

NED4L_HUMAN
NC score	0.176693 (rank : 99)	θ value	0.163984 (rank : 108)
Query Neighborhood Hits	148	Target Neighborhood Hits	238	Shared Neighborhood Hits	81
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.173539 (rank : 100)	θ value	0.163984 (rank : 109)
Query Neighborhood Hits	148	Target Neighborhood Hits	231	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

TAC2N_HUMAN
NC score	0.171345 (rank : 101)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	148	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
NC score	0.170709 (rank : 102)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	148	Target Neighborhood Hits	43	Shared Neighborhood Hits	36
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

UN13B_MOUSE
NC score	0.168270 (rank : 103)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	148	Target Neighborhood Hits	210	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

RASA3_MOUSE
NC score	0.166787 (rank : 104)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	148	Target Neighborhood Hits	144	Shared Neighborhood Hits	65
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

UN13B_HUMAN
NC score	0.166558 (rank : 105)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	148	Target Neighborhood Hits	217	Shared Neighborhood Hits	66
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

RGS3_HUMAN
NC score	0.164436 (rank : 106)	θ value	3.19293e-05 (rank : 77)
Query Neighborhood Hits	148	Target Neighborhood Hits	1375	Shared Neighborhood Hits	84
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

NEDD4_HUMAN
NC score	0.163516 (rank : 107)	θ value	0.0148317 (rank : 95)
Query Neighborhood Hits	148	Target Neighborhood Hits	214	Shared Neighborhood Hits	78
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

UN13A_HUMAN
NC score	0.161566 (rank : 108)	θ value	1.06291 (rank : 120)
Query Neighborhood Hits	148	Target Neighborhood Hits	285	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

PA24D_MOUSE
NC score	0.160090 (rank : 109)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	64
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RFIP2_HUMAN
NC score	0.154254 (rank : 110)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	148	Target Neighborhood Hits	97	Shared Neighborhood Hits	59
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

NEDD4_MOUSE
NC score	0.153763 (rank : 111)	θ value	0.0330416 (rank : 100)
Query Neighborhood Hits	148	Target Neighborhood Hits	212	Shared Neighborhood Hits	77
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

OTOF_HUMAN
NC score	0.153717 (rank : 112)	θ value	5.27518 (rank : 133)
Query Neighborhood Hits	148	Target Neighborhood Hits	168	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
NC score	0.151831 (rank : 113)	θ value	4.03905 (rank : 129)
Query Neighborhood Hits	148	Target Neighborhood Hits	196	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

PA24D_HUMAN
NC score	0.135471 (rank : 114)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	148	Target Neighborhood Hits	97	Shared Neighborhood Hits	61
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

KPCG_MOUSE
NC score	0.135202 (rank : 115)	θ value	7.34386e-10 (rank : 50)
Query Neighborhood Hits	148	Target Neighborhood Hits	1123	Shared Neighborhood Hits	86
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
NC score	0.134052 (rank : 116)	θ value	3.64472e-09 (rank : 58)
Query Neighborhood Hits	148	Target Neighborhood Hits	1126	Shared Neighborhood Hits	86
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCA_HUMAN
NC score	0.128977 (rank : 117)	θ value	9.59137e-10 (rank : 53)
Query Neighborhood Hits	148	Target Neighborhood Hits	1070	Shared Neighborhood Hits	88
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
NC score	0.125486 (rank : 118)	θ value	8.11959e-09 (rank : 62)
Query Neighborhood Hits	148	Target Neighborhood Hits	1067	Shared Neighborhood Hits	88
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
NC score	0.124061 (rank : 119)	θ value	6.87365e-08 (rank : 66)
Query Neighborhood Hits	148	Target Neighborhood Hits	1121	Shared Neighborhood Hits	87
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
NC score	0.124037 (rank : 120)	θ value	1.99992e-07 (rank : 67)
Query Neighborhood Hits	148	Target Neighborhood Hits	1117	Shared Neighborhood Hits	86
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PA24B_MOUSE
NC score	0.117004 (rank : 121)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	148	Target Neighborhood Hits	102	Shared Neighborhood Hits	55
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

NCF1_HUMAN
NC score	0.109526 (rank : 122)	θ value	9.29e-05 (rank : 80)
Query Neighborhood Hits	148	Target Neighborhood Hits	198	Shared Neighborhood Hits	13
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PA24E_MOUSE
NC score	0.107512 (rank : 123)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	148	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

NCF1_MOUSE
NC score	0.101927 (rank : 124)	θ value	7.1131e-05 (rank : 79)
Query Neighborhood Hits	148	Target Neighborhood Hits	198	Shared Neighborhood Hits	11
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PA24A_MOUSE
NC score	0.099865 (rank : 125)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	60
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

CPNE3_MOUSE
NC score	0.097265 (rank : 126)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	148	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE3_HUMAN
NC score	0.097106 (rank : 127)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	148	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

PA24E_HUMAN
NC score	0.094751 (rank : 128)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	148	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24A_HUMAN
NC score	0.094229 (rank : 129)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	148	Target Neighborhood Hits	88	Shared Neighborhood Hits	61
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24B_HUMAN
NC score	0.091774 (rank : 130)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	148	Target Neighborhood Hits	89	Shared Neighborhood Hits	52
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

CPNE5_MOUSE
NC score	0.088752 (rank : 131)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	148	Target Neighborhood Hits	86	Shared Neighborhood Hits	49
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_HUMAN
NC score	0.088477 (rank : 132)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	148	Target Neighborhood Hits	88	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

SNX16_MOUSE
NC score	0.088090 (rank : 133)	θ value	0.0193708 (rank : 98)
Query Neighborhood Hits	148	Target Neighborhood Hits	82	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C080	Gene names	Snx16
Domain Architecture	No domain graphic available
Description	Sorting nexin-16.

SNX16_HUMAN
NC score	0.085121 (rank : 134)	θ value	0.279714 (rank : 111)
Query Neighborhood Hits	148	Target Neighborhood Hits	110	Shared Neighborhood Hits	17
SwissProt Accessions	P57768, Q8N4U3	Gene names	SNX16
Domain Architecture
Description	Sorting nexin-16.

CPNE1_MOUSE
NC score	0.084898 (rank : 135)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	148	Target Neighborhood Hits	83	Shared Neighborhood Hits	50
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE2_MOUSE
NC score	0.084495 (rank : 136)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	148	Target Neighborhood Hits	82	Shared Neighborhood Hits	49
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE2_HUMAN
NC score	0.084474 (rank : 137)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	148	Target Neighborhood Hits	75	Shared Neighborhood Hits	46
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

ITSN2_HUMAN
NC score	0.083119 (rank : 138)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	148	Target Neighborhood Hits	1173	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CPNE8_HUMAN
NC score	0.082802 (rank : 139)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	148	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

MYRIP_MOUSE
NC score	0.080903 (rank : 140)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

CPNE8_MOUSE
NC score	0.080832 (rank : 141)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	148	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

MYRIP_HUMAN
NC score	0.076976 (rank : 142)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	148	Target Neighborhood Hits	269	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

CPNE7_HUMAN
NC score	0.075413 (rank : 143)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	148	Target Neighborhood Hits	92	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

ITSN2_MOUSE
NC score	0.074939 (rank : 144)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	148	Target Neighborhood Hits	1371	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PLCD1_HUMAN
NC score	0.071500 (rank : 145)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	42
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PA24F_MOUSE
NC score	0.070860 (rank : 146)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	49
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

MELPH_MOUSE
NC score	0.070699 (rank : 147)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	148	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

SNX18_HUMAN
NC score	0.070351 (rank : 148)	θ value	0.00020696 (rank : 82)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CPNE1_HUMAN
NC score	0.070196 (rank : 149)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	148	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

MELPH_HUMAN
NC score	0.069092 (rank : 150)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	148	Target Neighborhood Hits	145	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

SNX18_MOUSE
NC score	0.066900 (rank : 151)	θ value	0.00020696 (rank : 83)
Query Neighborhood Hits	148	Target Neighborhood Hits	198	Shared Neighborhood Hits	13
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

WWC1_MOUSE
NC score	0.066312 (rank : 152)	θ value	4.03905 (rank : 130)
Query Neighborhood Hits	148	Target Neighborhood Hits	290	Shared Neighborhood Hits	31
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

NCF4_HUMAN
NC score	0.063844 (rank : 153)	θ value	0.0563607 (rank : 102)
Query Neighborhood Hits	148	Target Neighborhood Hits	161	Shared Neighborhood Hits	18
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SNX22_HUMAN
NC score	0.063674 (rank : 154)	θ value	0.0148317 (rank : 96)
Query Neighborhood Hits	148	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q96L94, Q9H844	Gene names	SNX22
Domain Architecture
Description	Sorting nexin-22.

RFIP1_MOUSE
NC score	0.062919 (rank : 155)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	148	Target Neighborhood Hits	152	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

CPNE6_HUMAN
NC score	0.062733 (rank : 156)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	148	Target Neighborhood Hits	85	Shared Neighborhood Hits	48
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

SMUF1_HUMAN
NC score	0.059421 (rank : 157)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	148	Target Neighborhood Hits	135	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

CPNE6_MOUSE
NC score	0.059058 (rank : 158)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	148	Target Neighborhood Hits	87	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

SMUF1_MOUSE
NC score	0.058453 (rank : 159)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
NC score	0.058413 (rank : 160)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

ITSN1_MOUSE
NC score	0.058354 (rank : 161)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	148	Target Neighborhood Hits	1669	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.057959 (rank : 162)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	148	Target Neighborhood Hits	1757	Shared Neighborhood Hits	80
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

RFIP1_HUMAN
NC score	0.057415 (rank : 163)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	148	Target Neighborhood Hits	236	Shared Neighborhood Hits	31
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

PA24F_HUMAN
NC score	0.056152 (rank : 164)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	148	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

SNX24_HUMAN
NC score	0.054762 (rank : 165)	θ value	0.813845 (rank : 116)
Query Neighborhood Hits	148	Target Neighborhood Hits	42	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y343, Q6UY33	Gene names	SNX24
Domain Architecture
Description	Sorting nexin-24.

NOXO1_MOUSE
NC score	0.054649 (rank : 166)	θ value	0.813845 (rank : 115)
Query Neighborhood Hits	148	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SNX24_MOUSE
NC score	0.054170 (rank : 167)	θ value	0.813845 (rank : 117)
Query Neighborhood Hits	148	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CRB0	Gene names	Snx24
Domain Architecture	No domain graphic available
Description	Sorting nexin-24.

CPNE4_HUMAN
NC score	0.052457 (rank : 168)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	148	Target Neighborhood Hits	70	Shared Neighborhood Hits	43
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

NCF4_MOUSE
NC score	0.052410 (rank : 169)	θ value	0.0148317 (rank : 94)
Query Neighborhood Hits	148	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

CPNE4_MOUSE
NC score	0.051008 (rank : 170)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	148	Target Neighborhood Hits	67	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

RASA1_HUMAN
NC score	0.043704 (rank : 171)	θ value	0.21417 (rank : 110)
Query Neighborhood Hits	148	Target Neighborhood Hits	258	Shared Neighborhood Hits	24
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SGK3_MOUSE
NC score	0.027701 (rank : 172)	θ value	0.0961366 (rank : 104)
Query Neighborhood Hits	148	Target Neighborhood Hits	882	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SNX14_HUMAN
NC score	0.027665 (rank : 173)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	148	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

SGK3_HUMAN
NC score	0.027630 (rank : 174)	θ value	0.125558 (rank : 106)
Query Neighborhood Hits	148	Target Neighborhood Hits	877	Shared Neighborhood Hits	24
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SNX14_MOUSE
NC score	0.026517 (rank : 175)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	148	Target Neighborhood Hits	75	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

HRX_HUMAN
NC score	0.019297 (rank : 176)	θ value	0.813845 (rank : 113)
Query Neighborhood Hits	148	Target Neighborhood Hits	825	Shared Neighborhood Hits	16
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MUCDL_HUMAN
NC score	0.014690 (rank : 177)	θ value	1.06291 (rank : 119)
Query Neighborhood Hits	148	Target Neighborhood Hits	777	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

TRPV4_HUMAN
NC score	0.013569 (rank : 178)	θ value	0.0961366 (rank : 105)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

FYB_HUMAN
NC score	0.013230 (rank : 179)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	148	Target Neighborhood Hits	379	Shared Neighborhood Hits	8
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

ATF6B_HUMAN
NC score	0.013031 (rank : 180)	θ value	1.81305 (rank : 122)
Query Neighborhood Hits	148	Target Neighborhood Hits	122	Shared Neighborhood Hits	5
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

IQEC2_MOUSE
NC score	0.012171 (rank : 181)	θ value	2.36792 (rank : 128)
Query Neighborhood Hits	148	Target Neighborhood Hits	417	Shared Neighborhood Hits	10
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

HHIP_MOUSE
NC score	0.011834 (rank : 182)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	148	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TN16, Q8C0B0, Q9WU59	Gene names	Hhip, Hip
Domain Architecture	No domain graphic available
Description	Hedgehog-interacting protein precursor (HHIP) (HIP).

IQEC2_HUMAN
NC score	0.011821 (rank : 183)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	148	Target Neighborhood Hits	403	Shared Neighborhood Hits	9
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

GAB1_MOUSE
NC score	0.011424 (rank : 184)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	148	Target Neighborhood Hits	233	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

HHIP_HUMAN
NC score	0.010481 (rank : 185)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	148	Target Neighborhood Hits	249	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QV1, Q6PK09, Q8NCI7, Q9BXK3, Q9H1J4, Q9H7E7	Gene names	HHIP, HIP
Domain Architecture	No domain graphic available
Description	Hedgehog-interacting protein precursor (HHIP) (HIP).

KKCC2_MOUSE
NC score	0.010120 (rank : 186)	θ value	0.813845 (rank : 114)
Query Neighborhood Hits	148	Target Neighborhood Hits	855	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

GON4L_HUMAN
NC score	0.010008 (rank : 187)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	148	Target Neighborhood Hits	555	Shared Neighborhood Hits	13
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

DIDO1_HUMAN
NC score	0.008967 (rank : 188)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	148	Target Neighborhood Hits	960	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

LPIN1_HUMAN
NC score	0.004210 (rank : 189)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	148	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q14693	Gene names	LPIN1, KIAA0188
Domain Architecture
Description	Lipin-1.

MAP1A_HUMAN
NC score	0.002866 (rank : 190)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	148	Target Neighborhood Hits	1626	Shared Neighborhood Hits	13
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

ABCG4_HUMAN
NC score	0.002345 (rank : 191)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	148	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H172	Gene names	ABCG4, WHITE2
Domain Architecture
Description	ATP-binding cassette sub-family G member 4.

ABCAD_MOUSE
NC score	0.001816 (rank : 192)	θ value	5.27518 (rank : 131)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SSE9, Q80T20, Q8BHZ2, Q8CB91	Gene names	Abca13
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 13.

WDR33_HUMAN
NC score	0.000739 (rank : 193)	θ value	5.27518 (rank : 134)
Query Neighborhood Hits	148	Target Neighborhood Hits	638	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

TXLNA_MOUSE
NC score	0.000273 (rank : 194)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	148	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

CAC1B_HUMAN
NC score	0.000217 (rank : 195)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	148	Target Neighborhood Hits	257	Shared Neighborhood Hits	6
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

KMHN1_HUMAN
NC score	-0.003384 (rank : 196)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	148	Target Neighborhood Hits	950	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

OPSG_MOUSE
NC score	-0.004917 (rank : 197)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	148	Target Neighborhood Hits	717	Shared Neighborhood Hits	2
SwissProt Accessions	O35599, Q548Z4	Gene names	Opn1mw, Gcp
Domain Architecture
Description	Green-sensitive opsin (Green cone photoreceptor pigment) (Medium wavelength-sensitive cone opsin) (M opsin).

AIOL_HUMAN
NC score	-0.006912 (rank : 198)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	148	Target Neighborhood Hits	739	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKT9, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3	Gene names	IKZF3, ZNFN1A3
Domain Architecture	No domain graphic available
Description	Zinc finger protein Aiolos (IKAROS family zinc finger protein 3).