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Network neighborhood for query Sequence : RASL1_HUMAN

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RASL1_HUMAN
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RASL1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	142
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	0 (rank : 2)	NC score	0.995651 (rank : 2)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	137
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	0 (rank : 3)	NC score	0.962772 (rank : 3)
Query Neighborhood Hits	142	Target Neighborhood Hits	161	Shared Neighborhood Hits	128
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RASA3_HUMAN
θ value	3.4333e-100 (rank : 4)	NC score	0.850067 (rank : 4)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	96
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA3_MOUSE
θ value	4.34313e-95 (rank : 5)	NC score	0.833266 (rank : 7)
Query Neighborhood Hits	142	Target Neighborhood Hits	144	Shared Neighborhood Hits	90
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASA2_MOUSE
θ value	1.14825e-79 (rank : 6)	NC score	0.841510 (rank : 5)
Query Neighborhood Hits	142	Target Neighborhood Hits	159	Shared Neighborhood Hits	99
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_HUMAN
θ value	8.22888e-78 (rank : 7)	NC score	0.841474 (rank : 6)
Query Neighborhood Hits	142	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA1_HUMAN
θ value	2.59387e-31 (rank : 8)	NC score	0.491748 (rank : 41)
Query Neighborhood Hits	142	Target Neighborhood Hits	258	Shared Neighborhood Hits	46
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

NGAP_HUMAN
θ value	1.80048e-24 (rank : 9)	NC score	0.516366 (rank : 39)
Query Neighborhood Hits	142	Target Neighborhood Hits	517	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

SYGP1_HUMAN
θ value	2.59989e-23 (rank : 10)	NC score	0.493083 (rank : 40)
Query Neighborhood Hits	142	Target Neighborhood Hits	589	Shared Neighborhood Hits	25
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

DAB2P_MOUSE
θ value	4.43474e-23 (rank : 11)	NC score	0.544105 (rank : 32)
Query Neighborhood Hits	142	Target Neighborhood Hits	284	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DAB2P_HUMAN
θ value	9.87957e-23 (rank : 12)	NC score	0.545150 (rank : 31)
Query Neighborhood Hits	142	Target Neighborhood Hits	303	Shared Neighborhood Hits	24
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

SYT9_HUMAN
θ value	4.44505e-15 (rank : 13)	NC score	0.592224 (rank : 10)
Query Neighborhood Hits	142	Target Neighborhood Hits	144	Shared Neighborhood Hits	106
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	1.68911e-14 (rank : 14)	NC score	0.590899 (rank : 12)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT3_MOUSE
θ value	1.42992e-13 (rank : 15)	NC score	0.596923 (rank : 8)
Query Neighborhood Hits	142	Target Neighborhood Hits	147	Shared Neighborhood Hits	104
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT5_MOUSE
θ value	1.42992e-13 (rank : 16)	NC score	0.587851 (rank : 14)
Query Neighborhood Hits	142	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT2_HUMAN
θ value	1.86753e-13 (rank : 17)	NC score	0.582489 (rank : 20)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	107
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_HUMAN
θ value	1.86753e-13 (rank : 18)	NC score	0.587971 (rank : 13)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	107
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT2_MOUSE
θ value	2.43908e-13 (rank : 19)	NC score	0.583121 (rank : 18)
Query Neighborhood Hits	142	Target Neighborhood Hits	143	Shared Neighborhood Hits	107
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT3_HUMAN
θ value	2.43908e-13 (rank : 20)	NC score	0.595295 (rank : 9)
Query Neighborhood Hits	142	Target Neighborhood Hits	145	Shared Neighborhood Hits	104
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

KPCA_HUMAN
θ value	5.43371e-13 (rank : 21)	NC score	0.194922 (rank : 118)
Query Neighborhood Hits	142	Target Neighborhood Hits	1070	Shared Neighborhood Hits	122
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

NF1_HUMAN
θ value	5.43371e-13 (rank : 22)	NC score	0.443546 (rank : 51)
Query Neighborhood Hits	142	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

SYT6_HUMAN
θ value	5.43371e-13 (rank : 23)	NC score	0.579376 (rank : 22)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	104
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT7_HUMAN
θ value	5.43371e-13 (rank : 24)	NC score	0.591762 (rank : 11)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	108
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT6_MOUSE
θ value	7.09661e-13 (rank : 25)	NC score	0.579288 (rank : 23)
Query Neighborhood Hits	142	Target Neighborhood Hits	132	Shared Neighborhood Hits	104
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT1_HUMAN
θ value	1.58096e-12 (rank : 26)	NC score	0.584449 (rank : 16)
Query Neighborhood Hits	142	Target Neighborhood Hits	150	Shared Neighborhood Hits	107
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	1.58096e-12 (rank : 27)	NC score	0.584432 (rank : 17)
Query Neighborhood Hits	142	Target Neighborhood Hits	150	Shared Neighborhood Hits	107
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT7_MOUSE
θ value	1.58096e-12 (rank : 28)	NC score	0.585155 (rank : 15)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	110
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

NF1_MOUSE
θ value	3.52202e-12 (rank : 29)	NC score	0.445761 (rank : 49)
Query Neighborhood Hits	142	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

KPCG_MOUSE
θ value	6.00763e-12 (rank : 30)	NC score	0.201121 (rank : 115)
Query Neighborhood Hits	142	Target Neighborhood Hits	1123	Shared Neighborhood Hits	119
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
θ value	7.84624e-12 (rank : 31)	NC score	0.200729 (rank : 116)
Query Neighborhood Hits	142	Target Neighborhood Hits	1126	Shared Neighborhood Hits	120
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCA_MOUSE
θ value	1.74796e-11 (rank : 32)	NC score	0.190950 (rank : 123)
Query Neighborhood Hits	142	Target Neighborhood Hits	1067	Shared Neighborhood Hits	122
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYT10_HUMAN
θ value	1.74796e-11 (rank : 33)	NC score	0.577495 (rank : 26)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	105
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

OTOF_HUMAN
θ value	2.28291e-11 (rank : 34)	NC score	0.441897 (rank : 52)
Query Neighborhood Hits	142	Target Neighborhood Hits	168	Shared Neighborhood Hits	97
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
θ value	2.28291e-11 (rank : 35)	NC score	0.438515 (rank : 54)
Query Neighborhood Hits	142	Target Neighborhood Hits	196	Shared Neighborhood Hits	98
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

KPCB_HUMAN
θ value	2.98157e-11 (rank : 36)	NC score	0.193462 (rank : 121)
Query Neighborhood Hits	142	Target Neighborhood Hits	1121	Shared Neighborhood Hits	119
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

DYSF_HUMAN
θ value	3.89403e-11 (rank : 37)	NC score	0.431337 (rank : 56)
Query Neighborhood Hits	142	Target Neighborhood Hits	170	Shared Neighborhood Hits	108
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

KPCB_MOUSE
θ value	3.89403e-11 (rank : 38)	NC score	0.194365 (rank : 119)
Query Neighborhood Hits	142	Target Neighborhood Hits	1117	Shared Neighborhood Hits	119
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

SYT10_MOUSE
θ value	3.89403e-11 (rank : 39)	NC score	0.578097 (rank : 24)
Query Neighborhood Hits	142	Target Neighborhood Hits	133	Shared Neighborhood Hits	105
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

DOC2A_HUMAN
θ value	8.67504e-11 (rank : 40)	NC score	0.579636 (rank : 21)
Query Neighborhood Hits	142	Target Neighborhood Hits	144	Shared Neighborhood Hits	108
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	8.67504e-11 (rank : 41)	NC score	0.582812 (rank : 19)
Query Neighborhood Hits	142	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_HUMAN
θ value	1.47974e-10 (rank : 42)	NC score	0.577378 (rank : 27)
Query Neighborhood Hits	142	Target Neighborhood Hits	150	Shared Neighborhood Hits	110
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RP3A_HUMAN
θ value	1.47974e-10 (rank : 43)	NC score	0.554305 (rank : 28)
Query Neighborhood Hits	142	Target Neighborhood Hits	305	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

DOC2B_MOUSE
θ value	1.9326e-10 (rank : 44)	NC score	0.578091 (rank : 25)
Query Neighborhood Hits	142	Target Neighborhood Hits	169	Shared Neighborhood Hits	110
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RP3A_MOUSE
θ value	3.29651e-10 (rank : 45)	NC score	0.552668 (rank : 29)
Query Neighborhood Hits	142	Target Neighborhood Hits	510	Shared Neighborhood Hits	110
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

DYSF_MOUSE
θ value	1.25267e-09 (rank : 46)	NC score	0.422919 (rank : 63)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	103
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

BMX_HUMAN
θ value	4.76016e-09 (rank : 47)	NC score	0.091277 (rank : 148)
Query Neighborhood Hits	142	Target Neighborhood Hits	942	Shared Neighborhood Hits	29
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

IQGA1_MOUSE
θ value	4.76016e-09 (rank : 48)	NC score	0.236103 (rank : 105)
Query Neighborhood Hits	142	Target Neighborhood Hits	219	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JKF1	Gene names	Iqgap1
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1.

IQGA1_HUMAN
θ value	6.21693e-09 (rank : 49)	NC score	0.230508 (rank : 107)
Query Neighborhood Hits	142	Target Neighborhood Hits	250	Shared Neighborhood Hits	18
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

CPNE2_MOUSE
θ value	8.11959e-09 (rank : 50)	NC score	0.322890 (rank : 84)
Query Neighborhood Hits	142	Target Neighborhood Hits	82	Shared Neighborhood Hits	74
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

NED4L_HUMAN
θ value	1.06045e-08 (rank : 51)	NC score	0.348305 (rank : 75)
Query Neighborhood Hits	142	Target Neighborhood Hits	238	Shared Neighborhood Hits	108
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	1.06045e-08 (rank : 52)	NC score	0.345080 (rank : 76)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	107
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
θ value	1.06045e-08 (rank : 53)	NC score	0.320969 (rank : 86)
Query Neighborhood Hits	142	Target Neighborhood Hits	214	Shared Neighborhood Hits	101
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

MYOF_HUMAN
θ value	2.36244e-08 (rank : 54)	NC score	0.452679 (rank : 47)
Query Neighborhood Hits	142	Target Neighborhood Hits	147	Shared Neighborhood Hits	104
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

BMX_MOUSE
θ value	5.26297e-08 (rank : 55)	NC score	0.089820 (rank : 149)
Query Neighborhood Hits	142	Target Neighborhood Hits	912	Shared Neighborhood Hits	29
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

PCLO_HUMAN
θ value	5.26297e-08 (rank : 56)	NC score	0.366091 (rank : 70)
Query Neighborhood Hits	142	Target Neighborhood Hits	2046	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

NEDD4_MOUSE
θ value	6.87365e-08 (rank : 57)	NC score	0.316752 (rank : 89)
Query Neighborhood Hits	142	Target Neighborhood Hits	212	Shared Neighborhood Hits	101
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

UN13B_HUMAN
θ value	8.97725e-08 (rank : 58)	NC score	0.422022 (rank : 64)
Query Neighborhood Hits	142	Target Neighborhood Hits	217	Shared Neighborhood Hits	107
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13A_HUMAN
θ value	1.17247e-07 (rank : 59)	NC score	0.424416 (rank : 61)
Query Neighborhood Hits	142	Target Neighborhood Hits	285	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_MOUSE
θ value	1.17247e-07 (rank : 60)	NC score	0.431124 (rank : 58)
Query Neighborhood Hits	142	Target Neighborhood Hits	210	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CPNE1_MOUSE
θ value	1.99992e-07 (rank : 61)	NC score	0.312537 (rank : 90)
Query Neighborhood Hits	142	Target Neighborhood Hits	83	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

FA62A_MOUSE
θ value	1.99992e-07 (rank : 62)	NC score	0.549322 (rank : 30)
Query Neighborhood Hits	142	Target Neighborhood Hits	155	Shared Neighborhood Hits	110
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

PCLO_MOUSE
θ value	5.81887e-07 (rank : 63)	NC score	0.342695 (rank : 77)
Query Neighborhood Hits	142	Target Neighborhood Hits	2275	Shared Neighborhood Hits	109
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CPNE2_HUMAN
θ value	7.59969e-07 (rank : 64)	NC score	0.316928 (rank : 88)
Query Neighborhood Hits	142	Target Neighborhood Hits	75	Shared Neighborhood Hits	71
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

DOC2G_MOUSE
θ value	9.92553e-07 (rank : 65)	NC score	0.542462 (rank : 33)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	92
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

FA62A_HUMAN
θ value	1.29631e-06 (rank : 66)	NC score	0.534455 (rank : 35)
Query Neighborhood Hits	142	Target Neighborhood Hits	168	Shared Neighborhood Hits	109
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT4_MOUSE
θ value	1.29631e-06 (rank : 67)	NC score	0.536525 (rank : 34)
Query Neighborhood Hits	142	Target Neighborhood Hits	123	Shared Neighborhood Hits	93
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

CPNE1_HUMAN
θ value	2.21117e-06 (rank : 68)	NC score	0.283021 (rank : 96)
Query Neighborhood Hits	142	Target Neighborhood Hits	70	Shared Neighborhood Hits	69
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

RFIP2_HUMAN
θ value	2.88788e-06 (rank : 69)	NC score	0.432633 (rank : 55)
Query Neighborhood Hits	142	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

SYT4_HUMAN
θ value	3.77169e-06 (rank : 70)	NC score	0.534296 (rank : 36)
Query Neighborhood Hits	142	Target Neighborhood Hits	121	Shared Neighborhood Hits	91
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

IQGA2_HUMAN
θ value	1.09739e-05 (rank : 71)	NC score	0.242151 (rank : 104)
Query Neighborhood Hits	142	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

PA24D_MOUSE
θ value	1.87187e-05 (rank : 72)	NC score	0.339124 (rank : 78)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

IQGA3_HUMAN
θ value	9.29e-05 (rank : 73)	NC score	0.215207 (rank : 110)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

ITSN2_HUMAN
θ value	0.000121331 (rank : 74)	NC score	0.178087 (rank : 128)
Query Neighborhood Hits	142	Target Neighborhood Hits	1173	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PERF_HUMAN
θ value	0.000121331 (rank : 75)	NC score	0.153469 (rank : 136)
Query Neighborhood Hits	142	Target Neighborhood Hits	48	Shared Neighborhood Hits	24
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

CPNE3_MOUSE
θ value	0.000158464 (rank : 76)	NC score	0.327210 (rank : 83)
Query Neighborhood Hits	142	Target Neighborhood Hits	90	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE8_HUMAN
θ value	0.00020696 (rank : 77)	NC score	0.310234 (rank : 91)
Query Neighborhood Hits	142	Target Neighborhood Hits	86	Shared Neighborhood Hits	76
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

PERF_MOUSE
θ value	0.00020696 (rank : 78)	NC score	0.162951 (rank : 135)
Query Neighborhood Hits	142	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

ITK_MOUSE
θ value	0.000270298 (rank : 79)	NC score	0.081349 (rank : 154)
Query Neighborhood Hits	142	Target Neighborhood Hits	985	Shared Neighborhood Hits	31
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITSN2_MOUSE
θ value	0.000270298 (rank : 80)	NC score	0.167681 (rank : 134)
Query Neighborhood Hits	142	Target Neighborhood Hits	1371	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

RFIP1_HUMAN
θ value	0.000270298 (rank : 81)	NC score	0.213859 (rank : 112)
Query Neighborhood Hits	142	Target Neighborhood Hits	236	Shared Neighborhood Hits	43
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

SYT11_HUMAN
θ value	0.000270298 (rank : 82)	NC score	0.521219 (rank : 38)
Query Neighborhood Hits	142	Target Neighborhood Hits	113	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	0.000270298 (rank : 83)	NC score	0.522874 (rank : 37)
Query Neighborhood Hits	142	Target Neighborhood Hits	116	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

KPCE_MOUSE
θ value	0.00035302 (rank : 84)	NC score	0.071731 (rank : 164)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	39
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

SYT12_HUMAN
θ value	0.00035302 (rank : 85)	NC score	0.469648 (rank : 43)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

CPNE5_HUMAN
θ value	0.000461057 (rank : 86)	NC score	0.310006 (rank : 92)
Query Neighborhood Hits	142	Target Neighborhood Hits	88	Shared Neighborhood Hits	75
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

KPCE_HUMAN
θ value	0.000461057 (rank : 87)	NC score	0.071362 (rank : 165)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	39
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

CPNE5_MOUSE
θ value	0.000602161 (rank : 88)	NC score	0.309920 (rank : 93)
Query Neighborhood Hits	142	Target Neighborhood Hits	86	Shared Neighborhood Hits	75
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

ITK_HUMAN
θ value	0.000786445 (rank : 89)	NC score	0.079217 (rank : 155)
Query Neighborhood Hits	142	Target Neighborhood Hits	1016	Shared Neighborhood Hits	31
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

RFIP1_MOUSE
θ value	0.000786445 (rank : 90)	NC score	0.211097 (rank : 113)
Query Neighborhood Hits	142	Target Neighborhood Hits	152	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RIMS2_MOUSE
θ value	0.00102713 (rank : 91)	NC score	0.336792 (rank : 80)
Query Neighborhood Hits	142	Target Neighborhood Hits	376	Shared Neighborhood Hits	86
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SMUF1_HUMAN
θ value	0.00102713 (rank : 92)	NC score	0.175806 (rank : 129)
Query Neighborhood Hits	142	Target Neighborhood Hits	135	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	0.00102713 (rank : 93)	NC score	0.174563 (rank : 131)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SYT12_MOUSE
θ value	0.00102713 (rank : 94)	NC score	0.472440 (rank : 42)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	75
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

CPNE8_MOUSE
θ value	0.00134147 (rank : 95)	NC score	0.303418 (rank : 94)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	75
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

SYTL2_HUMAN
θ value	0.00228821 (rank : 96)	NC score	0.462660 (rank : 44)
Query Neighborhood Hits	142	Target Neighborhood Hits	248	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SMUF2_HUMAN
θ value	0.00298849 (rank : 97)	NC score	0.175373 (rank : 130)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

RIMS2_HUMAN
θ value	0.00390308 (rank : 98)	NC score	0.338712 (rank : 79)
Query Neighborhood Hits	142	Target Neighborhood Hits	342	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

CPNE3_HUMAN
θ value	0.00509761 (rank : 99)	NC score	0.317333 (rank : 87)
Query Neighborhood Hits	142	Target Neighborhood Hits	90	Shared Neighborhood Hits	78
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

PA24B_HUMAN
θ value	0.00665767 (rank : 100)	NC score	0.228665 (rank : 109)
Query Neighborhood Hits	142	Target Neighborhood Hits	89	Shared Neighborhood Hits	70
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24D_HUMAN
θ value	0.00665767 (rank : 101)	NC score	0.284047 (rank : 95)
Query Neighborhood Hits	142	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

ITSN1_HUMAN
θ value	0.00869519 (rank : 102)	NC score	0.131521 (rank : 143)
Query Neighborhood Hits	142	Target Neighborhood Hits	1757	Shared Neighborhood Hits	94
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.00869519 (rank : 103)	NC score	0.133741 (rank : 141)
Query Neighborhood Hits	142	Target Neighborhood Hits	1669	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TEC_MOUSE
θ value	0.00869519 (rank : 104)	NC score	0.073275 (rank : 163)
Query Neighborhood Hits	142	Target Neighborhood Hits	1006	Shared Neighborhood Hits	34
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RIMS1_HUMAN
θ value	0.0113563 (rank : 105)	NC score	0.321808 (rank : 85)
Query Neighborhood Hits	142	Target Neighborhood Hits	437	Shared Neighborhood Hits	80
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

TEC_HUMAN
θ value	0.0113563 (rank : 106)	NC score	0.076503 (rank : 159)
Query Neighborhood Hits	142	Target Neighborhood Hits	1006	Shared Neighborhood Hits	34
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

K0528_HUMAN
θ value	0.0148317 (rank : 107)	NC score	0.363838 (rank : 72)
Query Neighborhood Hits	142	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	0.0148317 (rank : 108)	NC score	0.363435 (rank : 73)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

PA24B_MOUSE
θ value	0.0193708 (rank : 109)	NC score	0.270804 (rank : 98)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	79
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

SPTN4_HUMAN
θ value	0.0193708 (rank : 110)	NC score	0.027020 (rank : 202)
Query Neighborhood Hits	142	Target Neighborhood Hits	570	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SYTL4_HUMAN
θ value	0.0193708 (rank : 111)	NC score	0.443847 (rank : 50)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	79
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

UN13D_HUMAN
θ value	0.0193708 (rank : 112)	NC score	0.424033 (rank : 62)
Query Neighborhood Hits	142	Target Neighborhood Hits	117	Shared Neighborhood Hits	90
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

CPNE7_HUMAN
θ value	0.0252991 (rank : 113)	NC score	0.275354 (rank : 97)
Query Neighborhood Hits	142	Target Neighborhood Hits	92	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

SYTL2_MOUSE
θ value	0.0252991 (rank : 114)	NC score	0.458779 (rank : 45)
Query Neighborhood Hits	142	Target Neighborhood Hits	253	Shared Neighborhood Hits	88
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

PKHA1_MOUSE
θ value	0.0330416 (rank : 115)	NC score	0.136217 (rank : 138)
Query Neighborhood Hits	142	Target Neighborhood Hits	120	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

SYTL1_MOUSE
θ value	0.0431538 (rank : 116)	NC score	0.431260 (rank : 57)
Query Neighborhood Hits	142	Target Neighborhood Hits	314	Shared Neighborhood Hits	74
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL4_MOUSE
θ value	0.0431538 (rank : 117)	NC score	0.439391 (rank : 53)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	80
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

KPCL_MOUSE
θ value	0.0563607 (rank : 118)	NC score	0.069167 (rank : 170)
Query Neighborhood Hits	142	Target Neighborhood Hits	891	Shared Neighborhood Hits	40
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

CPNE4_HUMAN
θ value	0.0736092 (rank : 119)	NC score	0.247417 (rank : 101)
Query Neighborhood Hits	142	Target Neighborhood Hits	70	Shared Neighborhood Hits	65
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	0.0736092 (rank : 120)	NC score	0.246089 (rank : 102)
Query Neighborhood Hits	142	Target Neighborhood Hits	67	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

PKHA1_HUMAN
θ value	0.0736092 (rank : 121)	NC score	0.135913 (rank : 139)
Query Neighborhood Hits	142	Target Neighborhood Hits	127	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

SYTL1_HUMAN
θ value	0.0736092 (rank : 122)	NC score	0.457568 (rank : 46)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

BAIP3_HUMAN
θ value	0.125558 (rank : 123)	NC score	0.407869 (rank : 67)
Query Neighborhood Hits	142	Target Neighborhood Hits	108	Shared Neighborhood Hits	81
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

CPNE6_MOUSE
θ value	0.125558 (rank : 124)	NC score	0.250534 (rank : 100)
Query Neighborhood Hits	142	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

PA24E_MOUSE
θ value	0.163984 (rank : 125)	NC score	0.214536 (rank : 111)
Query Neighborhood Hits	142	Target Neighborhood Hits	95	Shared Neighborhood Hits	74
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PLCD1_HUMAN
θ value	0.163984 (rank : 126)	NC score	0.135709 (rank : 140)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	57
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

SPTB2_HUMAN
θ value	0.163984 (rank : 127)	NC score	0.017248 (rank : 205)
Query Neighborhood Hits	142	Target Neighborhood Hits	748	Shared Neighborhood Hits	13
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

BAIP3_MOUSE
θ value	0.21417 (rank : 128)	NC score	0.408446 (rank : 66)
Query Neighborhood Hits	142	Target Neighborhood Hits	112	Shared Neighborhood Hits	93
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

CPNE6_HUMAN
θ value	0.21417 (rank : 129)	NC score	0.250758 (rank : 99)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	70
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

DGKH_HUMAN
θ value	0.21417 (rank : 130)	NC score	0.100702 (rank : 144)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

SPTB2_MOUSE
θ value	0.365318 (rank : 131)	NC score	0.016968 (rank : 206)
Query Neighborhood Hits	142	Target Neighborhood Hits	770	Shared Neighborhood Hits	14
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

PA24F_MOUSE
θ value	0.47712 (rank : 132)	NC score	0.170702 (rank : 132)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	69
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

SYTL5_HUMAN
θ value	0.47712 (rank : 133)	NC score	0.429797 (rank : 60)
Query Neighborhood Hits	142	Target Neighborhood Hits	237	Shared Neighborhood Hits	96
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

BTK_HUMAN
θ value	0.813845 (rank : 134)	NC score	0.070911 (rank : 168)
Query Neighborhood Hits	142	Target Neighborhood Hits	1026	Shared Neighborhood Hits	31
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	0.813845 (rank : 135)	NC score	0.071213 (rank : 166)
Query Neighborhood Hits	142	Target Neighborhood Hits	1017	Shared Neighborhood Hits	31
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

KPCL_HUMAN
θ value	0.813845 (rank : 136)	NC score	0.063951 (rank : 177)
Query Neighborhood Hits	142	Target Neighborhood Hits	887	Shared Neighborhood Hits	36
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

PSB10_MOUSE
θ value	1.06291 (rank : 137)	NC score	0.018493 (rank : 204)
Query Neighborhood Hits	142	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	O35955, O08687, Q99KC5	Gene names	Psmb10, Lmp10, Mecl1
Domain Architecture
Description	Proteasome subunit beta type 10 precursor (EC 3.4.25.1) (Proteasome MECl-1) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1).

RTN4R_MOUSE
θ value	1.81305 (rank : 138)	NC score	0.001766 (rank : 208)
Query Neighborhood Hits	142	Target Neighborhood Hits	293	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

SYTL5_MOUSE
θ value	2.36792 (rank : 139)	NC score	0.420760 (rank : 65)
Query Neighborhood Hits	142	Target Neighborhood Hits	154	Shared Neighborhood Hits	95
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

PA24F_HUMAN
θ value	6.88961 (rank : 140)	NC score	0.144769 (rank : 137)
Query Neighborhood Hits	142	Target Neighborhood Hits	78	Shared Neighborhood Hits	63
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

SPEG_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.025280 (rank : 203)
Query Neighborhood Hits	142	Target Neighborhood Hits	1762	Shared Neighborhood Hits	28
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PARP3_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.011845 (rank : 207)
Query Neighborhood Hits	142	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6F1, Q8NER9, Q96CG2, Q9UG81	Gene names	PARP3, ADPRT3, ADPRTL3
Domain Architecture
Description	Poly [ADP-ribose] polymerase 3 (EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3) (Poly[ADP-ribose] synthetase 3) (pADPRT-3) (hPARP-3) (IRT1).

CHIN_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.053645 (rank : 195)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	15
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.054020 (rank : 194)
Query Neighborhood Hits	142	Target Neighborhood Hits	229	Shared Neighborhood Hits	15
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.054548 (rank : 191)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	15
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.052230 (rank : 198)
Query Neighborhood Hits	142	Target Neighborhood Hits	130	Shared Neighborhood Hits	14
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

DAPP1_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.088697 (rank : 151)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.087353 (rank : 152)
Query Neighborhood Hits	142	Target Neighborhood Hits	225	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DGKD_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.089291 (rank : 150)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	23
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKQ_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.067340 (rank : 173)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

GRP3_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.076059 (rank : 160)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HECD2_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.061169 (rank : 183)
Query Neighborhood Hits	142	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.061722 (rank : 179)
Query Neighborhood Hits	142	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC3_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.050579 (rank : 200)
Query Neighborhood Hits	142	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.054164 (rank : 193)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.064476 (rank : 176)
Query Neighborhood Hits	142	Target Neighborhood Hits	443	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.064479 (rank : 175)
Query Neighborhood Hits	142	Target Neighborhood Hits	406	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ITCH_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.078795 (rank : 156)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	27
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.077259 (rank : 158)
Query Neighborhood Hits	142	Target Neighborhood Hits	127	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

K0317_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.067566 (rank : 172)
Query Neighborhood Hits	142	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.067664 (rank : 171)
Query Neighborhood Hits	142	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

KPCD_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.050533 (rank : 201)
Query Neighborhood Hits	142	Target Neighborhood Hits	888	Shared Neighborhood Hits	23
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

P3C2A_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.191061 (rank : 122)
Query Neighborhood Hits	142	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.190052 (rank : 124)
Query Neighborhood Hits	142	Target Neighborhood Hits	181	Shared Neighborhood Hits	62
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.245182 (rank : 103)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	67
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PA24A_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.169963 (rank : 133)
Query Neighborhood Hits	142	Target Neighborhood Hits	88	Shared Neighborhood Hits	69
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24A_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.179342 (rank : 127)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	69
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24E_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.194139 (rank : 120)
Query Neighborhood Hits	142	Target Neighborhood Hits	89	Shared Neighborhood Hits	74
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PDZD8_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.058083 (rank : 189)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PKHA2_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.084656 (rank : 153)
Query Neighborhood Hits	142	Target Neighborhood Hits	119	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.100093 (rank : 145)
Query Neighborhood Hits	142	Target Neighborhood Hits	116	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PLCD1_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.098668 (rank : 146)
Query Neighborhood Hits	142	Target Neighborhood Hits	106	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

RASF1_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.054410 (rank : 192)
Query Neighborhood Hits	142	Target Neighborhood Hits	62	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.065525 (rank : 174)
Query Neighborhood Hits	142	Target Neighborhood Hits	74	Shared Neighborhood Hits	14
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RFIP5_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.063240 (rank : 178)
Query Neighborhood Hits	142	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BXF6, O94939, Q9P0M1	Gene names	RAB11FIP5, GAF1, KIAA0857, RIP11
Domain Architecture
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75).

RFIP5_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.059252 (rank : 188)
Query Neighborhood Hits	142	Target Neighborhood Hits	126	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

RGS3_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.133151 (rank : 142)
Query Neighborhood Hits	142	Target Neighborhood Hits	1375	Shared Neighborhood Hits	66
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RIMS3_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.201708 (rank : 114)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.197512 (rank : 117)
Query Neighborhood Hits	142	Target Neighborhood Hits	67	Shared Neighborhood Hits	53
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.230047 (rank : 108)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.231361 (rank : 106)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

STAC3_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.060869 (rank : 184)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.061207 (rank : 182)
Query Neighborhood Hits	142	Target Neighborhood Hits	232	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.052491 (rank : 197)
Query Neighborhood Hits	142	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.056234 (rank : 190)
Query Neighborhood Hits	142	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SYT13_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.365757 (rank : 71)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.361394 (rank : 74)
Query Neighborhood Hits	142	Target Neighborhood Hits	69	Shared Neighborhood Hits	57
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT14_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.327482 (rank : 82)
Query Neighborhood Hits	142	Target Neighborhood Hits	81	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.332791 (rank : 81)
Query Neighborhood Hits	142	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT15_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.431005 (rank : 59)
Query Neighborhood Hits	142	Target Neighborhood Hits	112	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT15_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.407245 (rank : 68)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYT8_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.447760 (rank : 48)
Query Neighborhood Hits	142	Target Neighborhood Hits	94	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYTL3_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.383929 (rank : 69)
Query Neighborhood Hits	142	Target Neighborhood Hits	110	Shared Neighborhood Hits	66
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

TAC2N_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.189496 (rank : 125)
Query Neighborhood Hits	142	Target Neighborhood Hits	47	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.184778 (rank : 126)
Query Neighborhood Hits	142	Target Neighborhood Hits	43	Shared Neighborhood Hits	29
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TOLIP_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.060360 (rank : 186)
Query Neighborhood Hits	142	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

TRIPC_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.051727 (rank : 199)
Query Neighborhood Hits	142	Target Neighborhood Hits	319	Shared Neighborhood Hits	9
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.060644 (rank : 185)
Query Neighborhood Hits	142	Target Neighborhood Hits	49	Shared Neighborhood Hits	7
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.060070 (rank : 187)
Query Neighborhood Hits	142	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.061284 (rank : 181)
Query Neighborhood Hits	142	Target Neighborhood Hits	51	Shared Neighborhood Hits	7
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.061530 (rank : 180)
Query Neighborhood Hits	142	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WWC1_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.074016 (rank : 162)
Query Neighborhood Hits	142	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.096716 (rank : 147)
Query Neighborhood Hits	142	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWP1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.075982 (rank : 161)
Query Neighborhood Hits	142	Target Neighborhood Hits	262	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.077622 (rank : 157)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.069917 (rank : 169)
Query Neighborhood Hits	142	Target Neighborhood Hits	177	Shared Neighborhood Hits	8
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.070951 (rank : 167)
Query Neighborhood Hits	142	Target Neighborhood Hits	118	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

YAP1_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.052508 (rank : 196)
Query Neighborhood Hits	142	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

RASL1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	142
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
NC score	0.995651 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	137
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
NC score	0.962772 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	142	Target Neighborhood Hits	161	Shared Neighborhood Hits	128
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RASA3_HUMAN
NC score	0.850067 (rank : 4)	θ value	3.4333e-100 (rank : 4)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	96
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA2_MOUSE
NC score	0.841510 (rank : 5)	θ value	1.14825e-79 (rank : 6)
Query Neighborhood Hits	142	Target Neighborhood Hits	159	Shared Neighborhood Hits	99
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_HUMAN
NC score	0.841474 (rank : 6)	θ value	8.22888e-78 (rank : 7)
Query Neighborhood Hits	142	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_MOUSE
NC score	0.833266 (rank : 7)	θ value	4.34313e-95 (rank : 5)
Query Neighborhood Hits	142	Target Neighborhood Hits	144	Shared Neighborhood Hits	90
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

SYT3_MOUSE
NC score	0.596923 (rank : 8)	θ value	1.42992e-13 (rank : 15)
Query Neighborhood Hits	142	Target Neighborhood Hits	147	Shared Neighborhood Hits	104
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_HUMAN
NC score	0.595295 (rank : 9)	θ value	2.43908e-13 (rank : 20)
Query Neighborhood Hits	142	Target Neighborhood Hits	145	Shared Neighborhood Hits	104
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT9_HUMAN
NC score	0.592224 (rank : 10)	θ value	4.44505e-15 (rank : 13)
Query Neighborhood Hits	142	Target Neighborhood Hits	144	Shared Neighborhood Hits	106
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT7_HUMAN
NC score	0.591762 (rank : 11)	θ value	5.43371e-13 (rank : 24)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	108
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT9_MOUSE
NC score	0.590899 (rank : 12)	θ value	1.68911e-14 (rank : 14)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT5_HUMAN
NC score	0.587971 (rank : 13)	θ value	1.86753e-13 (rank : 18)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	107
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT5_MOUSE
NC score	0.587851 (rank : 14)	θ value	1.42992e-13 (rank : 16)
Query Neighborhood Hits	142	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT7_MOUSE
NC score	0.585155 (rank : 15)	θ value	1.58096e-12 (rank : 28)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	110
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT1_HUMAN
NC score	0.584449 (rank : 16)	θ value	1.58096e-12 (rank : 26)
Query Neighborhood Hits	142	Target Neighborhood Hits	150	Shared Neighborhood Hits	107
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.584432 (rank : 17)	θ value	1.58096e-12 (rank : 27)
Query Neighborhood Hits	142	Target Neighborhood Hits	150	Shared Neighborhood Hits	107
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT2_MOUSE
NC score	0.583121 (rank : 18)	θ value	2.43908e-13 (rank : 19)
Query Neighborhood Hits	142	Target Neighborhood Hits	143	Shared Neighborhood Hits	107
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

DOC2A_MOUSE
NC score	0.582812 (rank : 19)	θ value	8.67504e-11 (rank : 41)
Query Neighborhood Hits	142	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

SYT2_HUMAN
NC score	0.582489 (rank : 20)	θ value	1.86753e-13 (rank : 17)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	107
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

DOC2A_HUMAN
NC score	0.579636 (rank : 21)	θ value	8.67504e-11 (rank : 40)
Query Neighborhood Hits	142	Target Neighborhood Hits	144	Shared Neighborhood Hits	108
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

SYT6_HUMAN
NC score	0.579376 (rank : 22)	θ value	5.43371e-13 (rank : 23)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	104
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
NC score	0.579288 (rank : 23)	θ value	7.09661e-13 (rank : 25)
Query Neighborhood Hits	142	Target Neighborhood Hits	132	Shared Neighborhood Hits	104
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT10_MOUSE
NC score	0.578097 (rank : 24)	θ value	3.89403e-11 (rank : 39)
Query Neighborhood Hits	142	Target Neighborhood Hits	133	Shared Neighborhood Hits	105
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

DOC2B_MOUSE
NC score	0.578091 (rank : 25)	θ value	1.9326e-10 (rank : 44)
Query Neighborhood Hits	142	Target Neighborhood Hits	169	Shared Neighborhood Hits	110
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

SYT10_HUMAN
NC score	0.577495 (rank : 26)	θ value	1.74796e-11 (rank : 33)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	105
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

DOC2B_HUMAN
NC score	0.577378 (rank : 27)	θ value	1.47974e-10 (rank : 42)
Query Neighborhood Hits	142	Target Neighborhood Hits	150	Shared Neighborhood Hits	110
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RP3A_HUMAN
NC score	0.554305 (rank : 28)	θ value	1.47974e-10 (rank : 43)
Query Neighborhood Hits	142	Target Neighborhood Hits	305	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
NC score	0.552668 (rank : 29)	θ value	3.29651e-10 (rank : 45)
Query Neighborhood Hits	142	Target Neighborhood Hits	510	Shared Neighborhood Hits	110
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

FA62A_MOUSE
NC score	0.549322 (rank : 30)	θ value	1.99992e-07 (rank : 62)
Query Neighborhood Hits	142	Target Neighborhood Hits	155	Shared Neighborhood Hits	110
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

DAB2P_HUMAN
NC score	0.545150 (rank : 31)	θ value	9.87957e-23 (rank : 12)
Query Neighborhood Hits	142	Target Neighborhood Hits	303	Shared Neighborhood Hits	24
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

DAB2P_MOUSE
NC score	0.544105 (rank : 32)	θ value	4.43474e-23 (rank : 11)
Query Neighborhood Hits	142	Target Neighborhood Hits	284	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DOC2G_MOUSE
NC score	0.542462 (rank : 33)	θ value	9.92553e-07 (rank : 65)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	92
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT4_MOUSE
NC score	0.536525 (rank : 34)	θ value	1.29631e-06 (rank : 67)
Query Neighborhood Hits	142	Target Neighborhood Hits	123	Shared Neighborhood Hits	93
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

FA62A_HUMAN
NC score	0.534455 (rank : 35)	θ value	1.29631e-06 (rank : 66)
Query Neighborhood Hits	142	Target Neighborhood Hits	168	Shared Neighborhood Hits	109
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT4_HUMAN
NC score	0.534296 (rank : 36)	θ value	3.77169e-06 (rank : 70)
Query Neighborhood Hits	142	Target Neighborhood Hits	121	Shared Neighborhood Hits	91
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT11_MOUSE
NC score	0.522874 (rank : 37)	θ value	0.000270298 (rank : 83)
Query Neighborhood Hits	142	Target Neighborhood Hits	116	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
NC score	0.521219 (rank : 38)	θ value	0.000270298 (rank : 82)
Query Neighborhood Hits	142	Target Neighborhood Hits	113	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

NGAP_HUMAN
NC score	0.516366 (rank : 39)	θ value	1.80048e-24 (rank : 9)
Query Neighborhood Hits	142	Target Neighborhood Hits	517	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

SYGP1_HUMAN
NC score	0.493083 (rank : 40)	θ value	2.59989e-23 (rank : 10)
Query Neighborhood Hits	142	Target Neighborhood Hits	589	Shared Neighborhood Hits	25
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

RASA1_HUMAN
NC score	0.491748 (rank : 41)	θ value	2.59387e-31 (rank : 8)
Query Neighborhood Hits	142	Target Neighborhood Hits	258	Shared Neighborhood Hits	46
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SYT12_MOUSE
NC score	0.472440 (rank : 42)	θ value	0.00102713 (rank : 94)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	75
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT12_HUMAN
NC score	0.469648 (rank : 43)	θ value	0.00035302 (rank : 85)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYTL2_HUMAN
NC score	0.462660 (rank : 44)	θ value	0.00228821 (rank : 96)
Query Neighborhood Hits	142	Target Neighborhood Hits	248	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
NC score	0.458779 (rank : 45)	θ value	0.0252991 (rank : 114)
Query Neighborhood Hits	142	Target Neighborhood Hits	253	Shared Neighborhood Hits	88
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL1_HUMAN
NC score	0.457568 (rank : 46)	θ value	0.0736092 (rank : 122)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

MYOF_HUMAN
NC score	0.452679 (rank : 47)	θ value	2.36244e-08 (rank : 54)
Query Neighborhood Hits	142	Target Neighborhood Hits	147	Shared Neighborhood Hits	104
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

SYT8_MOUSE
NC score	0.447760 (rank : 48)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	142	Target Neighborhood Hits	94	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

NF1_MOUSE
NC score	0.445761 (rank : 49)	θ value	3.52202e-12 (rank : 29)
Query Neighborhood Hits	142	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	Q04690, Q61956, Q61957	Gene names	Nf1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1).

SYTL4_HUMAN
NC score	0.443847 (rank : 50)	θ value	0.0193708 (rank : 111)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	79
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

NF1_HUMAN
NC score	0.443546 (rank : 51)	θ value	5.43371e-13 (rank : 22)
Query Neighborhood Hits	142	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	P21359, O00662, Q14284, Q14930, Q9UMK3	Gene names	NF1
Domain Architecture
Description	Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

OTOF_HUMAN
NC score	0.441897 (rank : 52)	θ value	2.28291e-11 (rank : 34)
Query Neighborhood Hits	142	Target Neighborhood Hits	168	Shared Neighborhood Hits	97
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

SYTL4_MOUSE
NC score	0.439391 (rank : 53)	θ value	0.0431538 (rank : 117)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	80
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

OTOF_MOUSE
NC score	0.438515 (rank : 54)	θ value	2.28291e-11 (rank : 35)
Query Neighborhood Hits	142	Target Neighborhood Hits	196	Shared Neighborhood Hits	98
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

RFIP2_HUMAN
NC score	0.432633 (rank : 55)	θ value	2.88788e-06 (rank : 69)
Query Neighborhood Hits	142	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

DYSF_HUMAN
NC score	0.431337 (rank : 56)	θ value	3.89403e-11 (rank : 37)
Query Neighborhood Hits	142	Target Neighborhood Hits	170	Shared Neighborhood Hits	108
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

SYTL1_MOUSE
NC score	0.431260 (rank : 57)	θ value	0.0431538 (rank : 116)
Query Neighborhood Hits	142	Target Neighborhood Hits	314	Shared Neighborhood Hits	74
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

UN13B_MOUSE
NC score	0.431124 (rank : 58)	θ value	1.17247e-07 (rank : 60)
Query Neighborhood Hits	142	Target Neighborhood Hits	210	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYT15_HUMAN
NC score	0.431005 (rank : 59)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	142	Target Neighborhood Hits	112	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYTL5_HUMAN
NC score	0.429797 (rank : 60)	θ value	0.47712 (rank : 133)
Query Neighborhood Hits	142	Target Neighborhood Hits	237	Shared Neighborhood Hits	96
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

UN13A_HUMAN
NC score	0.424416 (rank : 61)	θ value	1.17247e-07 (rank : 59)
Query Neighborhood Hits	142	Target Neighborhood Hits	285	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13D_HUMAN
NC score	0.424033 (rank : 62)	θ value	0.0193708 (rank : 112)
Query Neighborhood Hits	142	Target Neighborhood Hits	117	Shared Neighborhood Hits	90
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

DYSF_MOUSE
NC score	0.422919 (rank : 63)	θ value	1.25267e-09 (rank : 46)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	103
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

UN13B_HUMAN
NC score	0.422022 (rank : 64)	θ value	8.97725e-08 (rank : 58)
Query Neighborhood Hits	142	Target Neighborhood Hits	217	Shared Neighborhood Hits	107
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYTL5_MOUSE
NC score	0.420760 (rank : 65)	θ value	2.36792 (rank : 139)
Query Neighborhood Hits	142	Target Neighborhood Hits	154	Shared Neighborhood Hits	95
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

BAIP3_MOUSE
NC score	0.408446 (rank : 66)	θ value	0.21417 (rank : 128)
Query Neighborhood Hits	142	Target Neighborhood Hits	112	Shared Neighborhood Hits	93
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_HUMAN
NC score	0.407869 (rank : 67)	θ value	0.125558 (rank : 123)
Query Neighborhood Hits	142	Target Neighborhood Hits	108	Shared Neighborhood Hits	81
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

SYT15_MOUSE
NC score	0.407245 (rank : 68)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYTL3_MOUSE
NC score	0.383929 (rank : 69)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	142	Target Neighborhood Hits	110	Shared Neighborhood Hits	66
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

PCLO_HUMAN
NC score	0.366091 (rank : 70)	θ value	5.26297e-08 (rank : 56)
Query Neighborhood Hits	142	Target Neighborhood Hits	2046	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYT13_HUMAN
NC score	0.365757 (rank : 71)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

K0528_HUMAN
NC score	0.363838 (rank : 72)	θ value	0.0148317 (rank : 107)
Query Neighborhood Hits	142	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
NC score	0.363435 (rank : 73)	θ value	0.0148317 (rank : 108)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

SYT13_MOUSE
NC score	0.361394 (rank : 74)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	142	Target Neighborhood Hits	69	Shared Neighborhood Hits	57
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

NED4L_HUMAN
NC score	0.348305 (rank : 75)	θ value	1.06045e-08 (rank : 51)
Query Neighborhood Hits	142	Target Neighborhood Hits	238	Shared Neighborhood Hits	108
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.345080 (rank : 76)	θ value	1.06045e-08 (rank : 52)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	107
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PCLO_MOUSE
NC score	0.342695 (rank : 77)	θ value	5.81887e-07 (rank : 63)
Query Neighborhood Hits	142	Target Neighborhood Hits	2275	Shared Neighborhood Hits	109
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PA24D_MOUSE
NC score	0.339124 (rank : 78)	θ value	1.87187e-05 (rank : 72)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RIMS2_HUMAN
NC score	0.338712 (rank : 79)	θ value	0.00390308 (rank : 98)
Query Neighborhood Hits	142	Target Neighborhood Hits	342	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.336792 (rank : 80)	θ value	0.00102713 (rank : 91)
Query Neighborhood Hits	142	Target Neighborhood Hits	376	Shared Neighborhood Hits	86
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SYT14_MOUSE
NC score	0.332791 (rank : 81)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	142	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_HUMAN
NC score	0.327482 (rank : 82)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	142	Target Neighborhood Hits	81	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

CPNE3_MOUSE
NC score	0.327210 (rank : 83)	θ value	0.000158464 (rank : 76)
Query Neighborhood Hits	142	Target Neighborhood Hits	90	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE2_MOUSE
NC score	0.322890 (rank : 84)	θ value	8.11959e-09 (rank : 50)
Query Neighborhood Hits	142	Target Neighborhood Hits	82	Shared Neighborhood Hits	74
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

RIMS1_HUMAN
NC score	0.321808 (rank : 85)	θ value	0.0113563 (rank : 105)
Query Neighborhood Hits	142	Target Neighborhood Hits	437	Shared Neighborhood Hits	80
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

NEDD4_HUMAN
NC score	0.320969 (rank : 86)	θ value	1.06045e-08 (rank : 53)
Query Neighborhood Hits	142	Target Neighborhood Hits	214	Shared Neighborhood Hits	101
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

CPNE3_HUMAN
NC score	0.317333 (rank : 87)	θ value	0.00509761 (rank : 99)
Query Neighborhood Hits	142	Target Neighborhood Hits	90	Shared Neighborhood Hits	78
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE2_HUMAN
NC score	0.316928 (rank : 88)	θ value	7.59969e-07 (rank : 64)
Query Neighborhood Hits	142	Target Neighborhood Hits	75	Shared Neighborhood Hits	71
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

NEDD4_MOUSE
NC score	0.316752 (rank : 89)	θ value	6.87365e-08 (rank : 57)
Query Neighborhood Hits	142	Target Neighborhood Hits	212	Shared Neighborhood Hits	101
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

CPNE1_MOUSE
NC score	0.312537 (rank : 90)	θ value	1.99992e-07 (rank : 61)
Query Neighborhood Hits	142	Target Neighborhood Hits	83	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE8_HUMAN
NC score	0.310234 (rank : 91)	θ value	0.00020696 (rank : 77)
Query Neighborhood Hits	142	Target Neighborhood Hits	86	Shared Neighborhood Hits	76
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE5_HUMAN
NC score	0.310006 (rank : 92)	θ value	0.000461057 (rank : 86)
Query Neighborhood Hits	142	Target Neighborhood Hits	88	Shared Neighborhood Hits	75
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
NC score	0.309920 (rank : 93)	θ value	0.000602161 (rank : 88)
Query Neighborhood Hits	142	Target Neighborhood Hits	86	Shared Neighborhood Hits	75
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE8_MOUSE
NC score	0.303418 (rank : 94)	θ value	0.00134147 (rank : 95)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	75
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

PA24D_HUMAN
NC score	0.284047 (rank : 95)	θ value	0.00665767 (rank : 101)
Query Neighborhood Hits	142	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

CPNE1_HUMAN
NC score	0.283021 (rank : 96)	θ value	2.21117e-06 (rank : 68)
Query Neighborhood Hits	142	Target Neighborhood Hits	70	Shared Neighborhood Hits	69
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE7_HUMAN
NC score	0.275354 (rank : 97)	θ value	0.0252991 (rank : 113)
Query Neighborhood Hits	142	Target Neighborhood Hits	92	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

PA24B_MOUSE
NC score	0.270804 (rank : 98)	θ value	0.0193708 (rank : 109)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	79
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

CPNE6_HUMAN
NC score	0.250758 (rank : 99)	θ value	0.21417 (rank : 129)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	70
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_MOUSE
NC score	0.250534 (rank : 100)	θ value	0.125558 (rank : 124)
Query Neighborhood Hits	142	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE4_HUMAN
NC score	0.247417 (rank : 101)	θ value	0.0736092 (rank : 119)
Query Neighborhood Hits	142	Target Neighborhood Hits	70	Shared Neighborhood Hits	65
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
NC score	0.246089 (rank : 102)	θ value	0.0736092 (rank : 120)
Query Neighborhood Hits	142	Target Neighborhood Hits	67	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

P3C2B_HUMAN
NC score	0.245182 (rank : 103)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	67
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

IQGA2_HUMAN
NC score	0.242151 (rank : 104)	θ value	1.09739e-05 (rank : 71)
Query Neighborhood Hits	142	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

IQGA1_MOUSE
NC score	0.236103 (rank : 105)	θ value	4.76016e-09 (rank : 48)
Query Neighborhood Hits	142	Target Neighborhood Hits	219	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JKF1	Gene names	Iqgap1
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1.

RIMS4_MOUSE
NC score	0.231361 (rank : 106)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

IQGA1_HUMAN
NC score	0.230508 (rank : 107)	θ value	6.21693e-09 (rank : 49)
Query Neighborhood Hits	142	Target Neighborhood Hits	250	Shared Neighborhood Hits	18
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

RIMS4_HUMAN
NC score	0.230047 (rank : 108)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

PA24B_HUMAN
NC score	0.228665 (rank : 109)	θ value	0.00665767 (rank : 100)
Query Neighborhood Hits	142	Target Neighborhood Hits	89	Shared Neighborhood Hits	70
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

IQGA3_HUMAN
NC score	0.215207 (rank : 110)	θ value	9.29e-05 (rank : 73)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

PA24E_MOUSE
NC score	0.214536 (rank : 111)	θ value	0.163984 (rank : 125)
Query Neighborhood Hits	142	Target Neighborhood Hits	95	Shared Neighborhood Hits	74
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

RFIP1_HUMAN
NC score	0.213859 (rank : 112)	θ value	0.000270298 (rank : 81)
Query Neighborhood Hits	142	Target Neighborhood Hits	236	Shared Neighborhood Hits	43
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RFIP1_MOUSE
NC score	0.211097 (rank : 113)	θ value	0.000786445 (rank : 90)
Query Neighborhood Hits	142	Target Neighborhood Hits	152	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RIMS3_HUMAN
NC score	0.201708 (rank : 114)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

KPCG_MOUSE
NC score	0.201121 (rank : 115)	θ value	6.00763e-12 (rank : 30)
Query Neighborhood Hits	142	Target Neighborhood Hits	1123	Shared Neighborhood Hits	119
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
NC score	0.200729 (rank : 116)	θ value	7.84624e-12 (rank : 31)
Query Neighborhood Hits	142	Target Neighborhood Hits	1126	Shared Neighborhood Hits	120
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

RIMS3_MOUSE
NC score	0.197512 (rank : 117)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	142	Target Neighborhood Hits	67	Shared Neighborhood Hits	53
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

KPCA_HUMAN
NC score	0.194922 (rank : 118)	θ value	5.43371e-13 (rank : 21)
Query Neighborhood Hits	142	Target Neighborhood Hits	1070	Shared Neighborhood Hits	122
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_MOUSE
NC score	0.194365 (rank : 119)	θ value	3.89403e-11 (rank : 38)
Query Neighborhood Hits	142	Target Neighborhood Hits	1117	Shared Neighborhood Hits	119
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PA24E_HUMAN
NC score	0.194139 (rank : 120)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	142	Target Neighborhood Hits	89	Shared Neighborhood Hits	74
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

KPCB_HUMAN
NC score	0.193462 (rank : 121)	θ value	2.98157e-11 (rank : 36)
Query Neighborhood Hits	142	Target Neighborhood Hits	1121	Shared Neighborhood Hits	119
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

P3C2A_HUMAN
NC score	0.191061 (rank : 122)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	142	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

KPCA_MOUSE
NC score	0.190950 (rank : 123)	θ value	1.74796e-11 (rank : 32)
Query Neighborhood Hits	142	Target Neighborhood Hits	1067	Shared Neighborhood Hits	122
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

P3C2A_MOUSE
NC score	0.190052 (rank : 124)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	142	Target Neighborhood Hits	181	Shared Neighborhood Hits	62
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

TAC2N_HUMAN
NC score	0.189496 (rank : 125)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	142	Target Neighborhood Hits	47	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
NC score	0.184778 (rank : 126)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	142	Target Neighborhood Hits	43	Shared Neighborhood Hits	29
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

PA24A_MOUSE
NC score	0.179342 (rank : 127)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	69
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

ITSN2_HUMAN
NC score	0.178087 (rank : 128)	θ value	0.000121331 (rank : 74)
Query Neighborhood Hits	142	Target Neighborhood Hits	1173	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SMUF1_HUMAN
NC score	0.175806 (rank : 129)	θ value	0.00102713 (rank : 92)
Query Neighborhood Hits	142	Target Neighborhood Hits	135	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF2_HUMAN
NC score	0.175373 (rank : 130)	θ value	0.00298849 (rank : 97)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
NC score	0.174563 (rank : 131)	θ value	0.00102713 (rank : 93)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

PA24F_MOUSE
NC score	0.170702 (rank : 132)	θ value	0.47712 (rank : 132)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	69
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PA24A_HUMAN
NC score	0.169963 (rank : 133)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	142	Target Neighborhood Hits	88	Shared Neighborhood Hits	69
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

ITSN2_MOUSE
NC score	0.167681 (rank : 134)	θ value	0.000270298 (rank : 80)
Query Neighborhood Hits	142	Target Neighborhood Hits	1371	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PERF_MOUSE
NC score	0.162951 (rank : 135)	θ value	0.00020696 (rank : 78)
Query Neighborhood Hits	142	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

PERF_HUMAN
NC score	0.153469 (rank : 136)	θ value	0.000121331 (rank : 75)
Query Neighborhood Hits	142	Target Neighborhood Hits	48	Shared Neighborhood Hits	24
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

PA24F_HUMAN
NC score	0.144769 (rank : 137)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	142	Target Neighborhood Hits	78	Shared Neighborhood Hits	63
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PKHA1_MOUSE
NC score	0.136217 (rank : 138)	θ value	0.0330416 (rank : 115)
Query Neighborhood Hits	142	Target Neighborhood Hits	120	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.135913 (rank : 139)	θ value	0.0736092 (rank : 121)
Query Neighborhood Hits	142	Target Neighborhood Hits	127	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLCD1_HUMAN
NC score	0.135709 (rank : 140)	θ value	0.163984 (rank : 126)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	57
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

ITSN1_MOUSE
NC score	0.133741 (rank : 141)	θ value	0.00869519 (rank : 103)
Query Neighborhood Hits	142	Target Neighborhood Hits	1669	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RGS3_HUMAN
NC score	0.133151 (rank : 142)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	142	Target Neighborhood Hits	1375	Shared Neighborhood Hits	66
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ITSN1_HUMAN
NC score	0.131521 (rank : 143)	θ value	0.00869519 (rank : 102)
Query Neighborhood Hits	142	Target Neighborhood Hits	1757	Shared Neighborhood Hits	94
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

DGKH_HUMAN
NC score	0.100702 (rank : 144)	θ value	0.21417 (rank : 130)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PKHA2_MOUSE
NC score	0.100093 (rank : 145)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	142	Target Neighborhood Hits	116	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PLCD1_MOUSE
NC score	0.098668 (rank : 146)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	142	Target Neighborhood Hits	106	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

WWC1_MOUSE
NC score	0.096716 (rank : 147)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	142	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

BMX_HUMAN
NC score	0.091277 (rank : 148)	θ value	4.76016e-09 (rank : 47)
Query Neighborhood Hits	142	Target Neighborhood Hits	942	Shared Neighborhood Hits	29
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.089820 (rank : 149)	θ value	5.26297e-08 (rank : 55)
Query Neighborhood Hits	142	Target Neighborhood Hits	912	Shared Neighborhood Hits	29
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

DGKD_HUMAN
NC score	0.089291 (rank : 150)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	23
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DAPP1_HUMAN
NC score	0.088697 (rank : 151)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.087353 (rank : 152)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	142	Target Neighborhood Hits	225	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA2_HUMAN
NC score	0.084656 (rank : 153)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	142	Target Neighborhood Hits	119	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

ITK_MOUSE
NC score	0.081349 (rank : 154)	θ value	0.000270298 (rank : 79)
Query Neighborhood Hits	142	Target Neighborhood Hits	985	Shared Neighborhood Hits	31
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.079217 (rank : 155)	θ value	0.000786445 (rank : 89)
Query Neighborhood Hits	142	Target Neighborhood Hits	1016	Shared Neighborhood Hits	31
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITCH_HUMAN
NC score	0.078795 (rank : 156)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	27
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP1_MOUSE
NC score	0.077622 (rank : 157)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_MOUSE
NC score	0.077259 (rank : 158)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	142	Target Neighborhood Hits	127	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

TEC_HUMAN
NC score	0.076503 (rank : 159)	θ value	0.0113563 (rank : 106)
Query Neighborhood Hits	142	Target Neighborhood Hits	1006	Shared Neighborhood Hits	34
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

GRP3_HUMAN
NC score	0.076059 (rank : 160)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

WWP1_HUMAN
NC score	0.075982 (rank : 161)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	142	Target Neighborhood Hits	262	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWC1_HUMAN
NC score	0.074016 (rank : 162)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	142	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

TEC_MOUSE
NC score	0.073275 (rank : 163)	θ value	0.00869519 (rank : 104)
Query Neighborhood Hits	142	Target Neighborhood Hits	1006	Shared Neighborhood Hits	34
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

KPCE_MOUSE
NC score	0.071731 (rank : 164)	θ value	0.00035302 (rank : 84)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	39
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_HUMAN
NC score	0.071362 (rank : 165)	θ value	0.000461057 (rank : 87)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	39
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

BTK_MOUSE
NC score	0.071213 (rank : 166)	θ value	0.813845 (rank : 135)
Query Neighborhood Hits	142	Target Neighborhood Hits	1017	Shared Neighborhood Hits	31
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

WWP2_MOUSE
NC score	0.070951 (rank : 167)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	142	Target Neighborhood Hits	118	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

BTK_HUMAN
NC score	0.070911 (rank : 168)	θ value	0.813845 (rank : 134)
Query Neighborhood Hits	142	Target Neighborhood Hits	1026	Shared Neighborhood Hits	31
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

WWP2_HUMAN
NC score	0.069917 (rank : 169)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	142	Target Neighborhood Hits	177	Shared Neighborhood Hits	8
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

KPCL_MOUSE
NC score	0.069167 (rank : 170)	θ value	0.0563607 (rank : 118)
Query Neighborhood Hits	142	Target Neighborhood Hits	891	Shared Neighborhood Hits	40
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

K0317_MOUSE
NC score	0.067664 (rank : 171)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	142	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_HUMAN
NC score	0.067566 (rank : 172)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	142	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

DGKQ_HUMAN
NC score	0.067340 (rank : 173)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

RASF1_MOUSE
NC score	0.065525 (rank : 174)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	142	Target Neighborhood Hits	74	Shared Neighborhood Hits	14
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

HUWE1_MOUSE
NC score	0.064479 (rank : 175)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	142	Target Neighborhood Hits	406	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.064476 (rank : 176)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	142	Target Neighborhood Hits	443	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

KPCL_HUMAN
NC score	0.063951 (rank : 177)	θ value	0.813845 (rank : 136)
Query Neighborhood Hits	142	Target Neighborhood Hits	887	Shared Neighborhood Hits	36
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

RFIP5_HUMAN
NC score	0.063240 (rank : 178)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	142	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BXF6, O94939, Q9P0M1	Gene names	RAB11FIP5, GAF1, KIAA0857, RIP11
Domain Architecture
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75).

HECD2_MOUSE
NC score	0.061722 (rank : 179)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	142	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3C_MOUSE
NC score	0.061530 (rank : 180)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	142	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_HUMAN
NC score	0.061284 (rank : 181)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	142	Target Neighborhood Hits	51	Shared Neighborhood Hits	7
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

STAC3_MOUSE
NC score	0.061207 (rank : 182)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	142	Target Neighborhood Hits	232	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

HECD2_HUMAN
NC score	0.061169 (rank : 183)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	142	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

STAC3_HUMAN
NC score	0.060869 (rank : 184)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

UBE3A_HUMAN
NC score	0.060644 (rank : 185)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	142	Target Neighborhood Hits	49	Shared Neighborhood Hits	7
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

TOLIP_MOUSE
NC score	0.060360 (rank : 186)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	142	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

UBE3A_MOUSE
NC score	0.060070 (rank : 187)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	142	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

RFIP5_MOUSE
NC score	0.059252 (rank : 188)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	142	Target Neighborhood Hits	126	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

PDZD8_HUMAN
NC score	0.058083 (rank : 189)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

STAC_MOUSE
NC score	0.056234 (rank : 190)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	142	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CHIO_HUMAN
NC score	0.054548 (rank : 191)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	15
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RASF1_HUMAN
NC score	0.054410 (rank : 192)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	142	Target Neighborhood Hits	62	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

HERC5_HUMAN
NC score	0.054164 (rank : 193)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

CHIN_MOUSE
NC score	0.054020 (rank : 194)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	142	Target Neighborhood Hits	229	Shared Neighborhood Hits	15
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
NC score	0.053645 (rank : 195)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	15
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

YAP1_MOUSE
NC score	0.052508 (rank : 196)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	142	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

STAC_HUMAN
NC score	0.052491 (rank : 197)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	142	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CHIO_MOUSE
NC score	0.052230 (rank : 198)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	142	Target Neighborhood Hits	130	Shared Neighborhood Hits	14
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

TRIPC_HUMAN
NC score	0.051727 (rank : 199)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	142	Target Neighborhood Hits	319	Shared Neighborhood Hits	9
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC3_HUMAN
NC score	0.050579 (rank : 200)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	142	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

KPCD_MOUSE
NC score	0.050533 (rank : 201)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	142	Target Neighborhood Hits	888	Shared Neighborhood Hits	23
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

SPTN4_HUMAN
NC score	0.027020 (rank : 202)	θ value	0.0193708 (rank : 110)
Query Neighborhood Hits	142	Target Neighborhood Hits	570	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SPEG_HUMAN
NC score	0.025280 (rank : 203)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	142	Target Neighborhood Hits	1762	Shared Neighborhood Hits	28
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PSB10_MOUSE
NC score	0.018493 (rank : 204)	θ value	1.06291 (rank : 137)
Query Neighborhood Hits	142	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	O35955, O08687, Q99KC5	Gene names	Psmb10, Lmp10, Mecl1
Domain Architecture
Description	Proteasome subunit beta type 10 precursor (EC 3.4.25.1) (Proteasome MECl-1) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1).

SPTB2_HUMAN
NC score	0.017248 (rank : 205)	θ value	0.163984 (rank : 127)
Query Neighborhood Hits	142	Target Neighborhood Hits	748	Shared Neighborhood Hits	13
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.016968 (rank : 206)	θ value	0.365318 (rank : 131)
Query Neighborhood Hits	142	Target Neighborhood Hits	770	Shared Neighborhood Hits	14
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

PARP3_HUMAN
NC score	0.011845 (rank : 207)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	142	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6F1, Q8NER9, Q96CG2, Q9UG81	Gene names	PARP3, ADPRT3, ADPRTL3
Domain Architecture
Description	Poly [ADP-ribose] polymerase 3 (EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3) (Poly[ADP-ribose] synthetase 3) (pADPRT-3) (hPARP-3) (IRT1).

RTN4R_MOUSE
NC score	0.001766 (rank : 208)	θ value	1.81305 (rank : 138)
Query Neighborhood Hits	142	Target Neighborhood Hits	293	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).