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Network neighborhood for query Sequence : PLCD1_HUMAN

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PLCD1_HUMAN
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PLCD1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
θ value	0 (rank : 2)	NC score	0.989088 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	106	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCB2_HUMAN
θ value	2.91998e-83 (rank : 3)	NC score	0.756920 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	608	Shared Neighborhood Hits	17
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLCB1_HUMAN
θ value	4.21644e-82 (rank : 4)	NC score	0.743039 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	614	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB1_MOUSE
θ value	3.56943e-81 (rank : 5)	NC score	0.753636 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	531	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCG2_HUMAN
θ value	1.96772e-63 (rank : 6)	NC score	0.625746 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	280	Shared Neighborhood Hits	25
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_MOUSE
θ value	2.18062e-54 (rank : 7)	NC score	0.611318 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	26
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
θ value	1.08223e-53 (rank : 8)	NC score	0.617079 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCB4_HUMAN
θ value	1.788e-48 (rank : 9)	NC score	0.655236 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	658	Shared Neighborhood Hits	15
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PLCB3_HUMAN
θ value	3.98324e-48 (rank : 10)	NC score	0.748116 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	445	Shared Neighborhood Hits	14
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCB3_MOUSE
θ value	8.87376e-48 (rank : 11)	NC score	0.778129 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

SYT1_HUMAN
θ value	0.000270298 (rank : 12)	NC score	0.195491 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	56
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	0.000270298 (rank : 13)	NC score	0.195486 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	56
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

NED4L_HUMAN
θ value	0.000461057 (rank : 14)	NC score	0.131749 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	238	Shared Neighborhood Hits	58
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	0.000461057 (rank : 15)	NC score	0.130623 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	231	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SYT7_MOUSE
θ value	0.000461057 (rank : 16)	NC score	0.193260 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_HUMAN
θ value	0.000602161 (rank : 17)	NC score	0.193353 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

CPNE6_MOUSE
θ value	0.00175202 (rank : 18)	NC score	0.112916 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	87	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_HUMAN
θ value	0.00228821 (rank : 19)	NC score	0.110007 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	85	Shared Neighborhood Hits	46
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

SEGN_MOUSE
θ value	0.00228821 (rank : 20)	NC score	0.094152 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q91WD9	Gene names	Scgn
Domain Architecture
Description	Secretagogin.

SYT5_HUMAN
θ value	0.00228821 (rank : 21)	NC score	0.188725 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	56
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT11_HUMAN
θ value	0.00298849 (rank : 22)	NC score	0.181801 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	0.00298849 (rank : 23)	NC score	0.181803 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	116	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

NEDD4_MOUSE
θ value	0.00509761 (rank : 24)	NC score	0.116997 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	212	Shared Neighborhood Hits	55
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SYT5_MOUSE
θ value	0.00509761 (rank : 25)	NC score	0.188036 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	140	Shared Neighborhood Hits	57
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

RASL2_HUMAN
θ value	0.00665767 (rank : 26)	NC score	0.164242 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	161	Shared Neighborhood Hits	56
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

AB2BP_MOUSE
θ value	0.00869519 (rank : 27)	NC score	0.112551 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D6J4, Q3TYZ9, Q9ESR0	Gene names	Apba2bp, Xb51
Domain Architecture
Description	Amyloid beta A4 protein-binding family A member 2-binding protein (X11L-binding protein 51) (mXB51).

DOC2B_MOUSE
θ value	0.00869519 (rank : 28)	NC score	0.200412 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	169	Shared Neighborhood Hits	59
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

NEDD4_HUMAN
θ value	0.00869519 (rank : 29)	NC score	0.114560 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	214	Shared Neighborhood Hits	55
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

DOC2B_HUMAN
θ value	0.0113563 (rank : 30)	NC score	0.199983 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	59
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

SEGN_HUMAN
θ value	0.0113563 (rank : 31)	NC score	0.081930 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	O76038, Q5VV44, Q96QV7, Q9UJF6	Gene names	SCGN, SECRET
Domain Architecture
Description	Secretagogin.

SYT2_MOUSE
θ value	0.0113563 (rank : 32)	NC score	0.184312 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	143	Shared Neighborhood Hits	56
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

AB2BP_HUMAN
θ value	0.0148317 (rank : 33)	NC score	0.105803 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q96P71, Q5JWF6, Q5JWF7, Q86VV1, Q9H433, Q9H8G8, Q9HBW7, Q9HCQ9	Gene names	APBA2BP, NECAB3, NIP1, XB51
Domain Architecture
Description	Amyloid beta A4 protein-binding family A member 2-binding protein (Neuronal calcium-binding protein 3) (NECAB 3) (X11L-binding protein 51) (Nek2-interacting protein 1).

CALU_MOUSE
θ value	0.0193708 (rank : 34)	NC score	0.072908 (rank : 111)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	O35887	Gene names	Calu
Domain Architecture
Description	Calumenin precursor (Crocalbin).

DYSF_MOUSE
θ value	0.0193708 (rank : 35)	NC score	0.130611 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

KPCG_HUMAN
θ value	0.0193708 (rank : 36)	NC score	0.057352 (rank : 134)
Query Neighborhood Hits	93	Target Neighborhood Hits	1126	Shared Neighborhood Hits	59
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

SYT2_HUMAN
θ value	0.0193708 (rank : 37)	NC score	0.183638 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

KPCA_MOUSE
θ value	0.0252991 (rank : 38)	NC score	0.054210 (rank : 142)
Query Neighborhood Hits	93	Target Neighborhood Hits	1067	Shared Neighborhood Hits	61
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCG_MOUSE
θ value	0.0252991 (rank : 39)	NC score	0.057690 (rank : 132)
Query Neighborhood Hits	93	Target Neighborhood Hits	1123	Shared Neighborhood Hits	59
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

DOC2A_MOUSE
θ value	0.0330416 (rank : 40)	NC score	0.210204 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	140	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

MYOF_HUMAN
θ value	0.0330416 (rank : 41)	NC score	0.141288 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	147	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

CALU_HUMAN
θ value	0.0431538 (rank : 42)	NC score	0.068993 (rank : 118)
Query Neighborhood Hits	93	Target Neighborhood Hits	114	Shared Neighborhood Hits	8
SwissProt Accessions	O43852, O60456, Q6FHB9, Q96RL3, Q9NR43	Gene names	CALU
Domain Architecture
Description	Calumenin precursor (Crocalbin) (IEF SSP 9302).

DOC2A_HUMAN
θ value	0.0563607 (rank : 43)	NC score	0.206067 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	60
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

KPCA_HUMAN
θ value	0.0736092 (rank : 44)	NC score	0.052609 (rank : 150)
Query Neighborhood Hits	93	Target Neighborhood Hits	1070	Shared Neighborhood Hits	60
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYT3_HUMAN
θ value	0.0961366 (rank : 45)	NC score	0.173379 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	145	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	0.125558 (rank : 46)	NC score	0.173200 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	147	Shared Neighborhood Hits	56
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

K0528_HUMAN
θ value	0.163984 (rank : 47)	NC score	0.157497 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	0.163984 (rank : 48)	NC score	0.157216 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	102	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

RASL1_HUMAN
θ value	0.163984 (rank : 49)	NC score	0.135709 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	57
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

KPCB_HUMAN
θ value	0.21417 (rank : 50)	NC score	0.052485 (rank : 151)
Query Neighborhood Hits	93	Target Neighborhood Hits	1121	Shared Neighborhood Hits	61
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	0.21417 (rank : 51)	NC score	0.053154 (rank : 148)
Query Neighborhood Hits	93	Target Neighborhood Hits	1117	Shared Neighborhood Hits	61
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

RP3A_HUMAN
θ value	0.21417 (rank : 52)	NC score	0.172219 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	305	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
θ value	0.21417 (rank : 53)	NC score	0.171811 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	510	Shared Neighborhood Hits	57
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

CAB45_MOUSE
θ value	0.279714 (rank : 54)	NC score	0.049706 (rank : 164)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q61112, Q61113	Gene names	Sdf4, Cab45
Domain Architecture	No domain graphic available
Description	45 kDa calcium-binding protein precursor (Cab45) (Stromal cell-derived factor 4) (SDF-4).

CPNE7_HUMAN
θ value	0.279714 (rank : 55)	NC score	0.089920 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

MCM8_HUMAN
θ value	0.279714 (rank : 56)	NC score	0.031181 (rank : 170)
Query Neighborhood Hits	93	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

PA24D_MOUSE
θ value	0.365318 (rank : 57)	NC score	0.115717 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	100	Shared Neighborhood Hits	51
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

BAIP3_HUMAN
θ value	0.47712 (rank : 58)	NC score	0.146076 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	108	Shared Neighborhood Hits	50
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

CU013_HUMAN
θ value	0.47712 (rank : 59)	NC score	0.045270 (rank : 165)
Query Neighborhood Hits	93	Target Neighborhood Hits	405	Shared Neighborhood Hits	8
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

KNTC2_MOUSE
θ value	0.47712 (rank : 60)	NC score	0.025827 (rank : 173)
Query Neighborhood Hits	93	Target Neighborhood Hits	692	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

SYT4_HUMAN
θ value	0.62314 (rank : 61)	NC score	0.170822 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	121	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

CPNE2_MOUSE
θ value	1.06291 (rank : 62)	NC score	0.086164 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	48
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

SYT4_MOUSE
θ value	1.06291 (rank : 63)	NC score	0.168679 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	123	Shared Neighborhood Hits	52
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

BAIP3_MOUSE
θ value	1.38821 (rank : 64)	NC score	0.141602 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	112	Shared Neighborhood Hits	51
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

CPNE2_HUMAN
θ value	1.38821 (rank : 65)	NC score	0.087010 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	75	Shared Neighborhood Hits	47
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

PLSI_HUMAN
θ value	1.38821 (rank : 66)	NC score	0.020308 (rank : 174)
Query Neighborhood Hits	93	Target Neighborhood Hits	209	Shared Neighborhood Hits	11
SwissProt Accessions	Q14651	Gene names	PLS1
Domain Architecture
Description	Plastin-1 (I-plastin) (Intestine-specific plastin).

NCOR2_HUMAN
θ value	1.81305 (rank : 67)	NC score	0.018718 (rank : 176)
Query Neighborhood Hits	93	Target Neighborhood Hits	870	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

SYT9_HUMAN
θ value	1.81305 (rank : 68)	NC score	0.161433 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	56
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

PCLO_MOUSE
θ value	2.36792 (rank : 69)	NC score	0.094518 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	2275	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYT9_MOUSE
θ value	2.36792 (rank : 70)	NC score	0.161038 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

UN13D_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.135838 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	52
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

CYLD_MOUSE
θ value	3.0926 (rank : 72)	NC score	0.028344 (rank : 171)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

DYSF_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.110793 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	56
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

MCM8_MOUSE
θ value	3.0926 (rank : 74)	NC score	0.019431 (rank : 175)
Query Neighborhood Hits	93	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

PCLO_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.097721 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	2046	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

TEX15_HUMAN
θ value	3.0926 (rank : 76)	NC score	0.037782 (rank : 167)
Query Neighborhood Hits	93	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXT5	Gene names	TEX15
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 15 protein.

CAB45_HUMAN
θ value	4.03905 (rank : 77)	NC score	0.040561 (rank : 166)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BRK5, Q8NBQ3, Q9NZP7	Gene names	SDF4, CAB45
Domain Architecture
Description	45 kDa calcium-binding protein precursor (Cab45) (Stromal cell-derived factor 4) (SDF-4).

CALB2_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.034771 (rank : 168)
Query Neighborhood Hits	93	Target Neighborhood Hits	149	Shared Neighborhood Hits	7
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

CYLD_HUMAN
θ value	4.03905 (rank : 79)	NC score	0.027177 (rank : 172)
Query Neighborhood Hits	93	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQC7, O94934, Q7L3N6, Q96EH0, Q9NZX9	Gene names	CYLD, CYLD1, KIAA0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

TEC_HUMAN
θ value	4.03905 (rank : 80)	NC score	0.016874 (rank : 177)
Query Neighborhood Hits	93	Target Neighborhood Hits	1006	Shared Neighborhood Hits	16
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

DOC2G_MOUSE
θ value	5.27518 (rank : 81)	NC score	0.170290 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

KNTC2_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.013567 (rank : 181)
Query Neighborhood Hits	93	Target Neighborhood Hits	673	Shared Neighborhood Hits	6
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

LX12E_MOUSE
θ value	5.27518 (rank : 83)	NC score	0.005980 (rank : 184)
Query Neighborhood Hits	93	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	P55249, Q91YW6	Gene names	Alox12e, Alox12-ps2, Aloxe
Domain Architecture
Description	Arachidonate 12-lipoxygenase, epidermal-type (EC 1.13.11.31) (12-LOX).

NSF1C_MOUSE
θ value	5.27518 (rank : 84)	NC score	0.012543 (rank : 182)
Query Neighborhood Hits	93	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZ44, Q80Y15, Q8BYL3	Gene names	Nsfl1c
Domain Architecture
Description	NSFL1 cofactor p47 (p97 cofactor p47).

SYT10_MOUSE
θ value	5.27518 (rank : 85)	NC score	0.157324 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	133	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT12_MOUSE
θ value	5.27518 (rank : 86)	NC score	0.137192 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	102	Shared Neighborhood Hits	46
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

TEC_MOUSE
θ value	6.88961 (rank : 87)	NC score	0.016382 (rank : 179)
Query Neighborhood Hits	93	Target Neighborhood Hits	1006	Shared Neighborhood Hits	16
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TF2LY_HUMAN
θ value	6.88961 (rank : 88)	NC score	0.016639 (rank : 178)
Query Neighborhood Hits	93	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IUE0	Gene names	TGIF2LY, TGIFLY
Domain Architecture
Description	Homeobox protein TGIF2LY (TGFB-induced factor 2-like protein, Y- linked) (TGF(beta)induced transcription factor 2-like protein) (TGIF- like on the Y).

CALB2_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.031741 (rank : 169)
Query Neighborhood Hits	93	Target Neighborhood Hits	141	Shared Neighborhood Hits	6
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

CPNE8_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.081956 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	86	Shared Neighborhood Hits	48
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

EFHC1_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.012279 (rank : 183)
Query Neighborhood Hits	93	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q5JVL4, Q5XKM4, Q6E1U7, Q6E1U8, Q8WUL2, Q9NVW6	Gene names	EFHC1
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing protein 1.

ROCK1_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.016089 (rank : 180)
Query Neighborhood Hits	93	Target Neighborhood Hits	2000	Shared Neighborhood Hits	21
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

TGFB2_MOUSE
θ value	8.99809 (rank : 93)	NC score	0.003354 (rank : 185)
Query Neighborhood Hits	93	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	P27090	Gene names	Tgfb2
Domain Architecture
Description	Transforming growth factor beta-2 precursor (TGF-beta-2).

APS_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.053981 (rank : 144)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CPNE1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.071450 (rank : 114)
Query Neighborhood Hits	93	Target Neighborhood Hits	70	Shared Neighborhood Hits	44
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE1_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.079170 (rank : 99)
Query Neighborhood Hits	93	Target Neighborhood Hits	83	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE3_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.085067 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	90	Shared Neighborhood Hits	46
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE3_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.086135 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE4_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.067210 (rank : 121)
Query Neighborhood Hits	93	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.066980 (rank : 122)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CPNE5_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.081611 (rank : 95)
Query Neighborhood Hits	93	Target Neighborhood Hits	88	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.081900 (rank : 94)
Query Neighborhood Hits	93	Target Neighborhood Hits	86	Shared Neighborhood Hits	47
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE8_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.078753 (rank : 100)
Query Neighborhood Hits	93	Target Neighborhood Hits	85	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

CRK_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.053408 (rank : 147)
Query Neighborhood Hits	93	Target Neighborhood Hits	308	Shared Neighborhood Hits	5
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.052240 (rank : 153)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	5
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.060246 (rank : 129)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.065341 (rank : 124)
Query Neighborhood Hits	93	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

FA62A_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.118789 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	168	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.120326 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	155	Shared Neighborhood Hits	54
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

GRAP_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.052060 (rank : 154)
Query Neighborhood Hits	93	Target Neighborhood Hits	307	Shared Neighborhood Hits	5
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.053646 (rank : 145)
Query Neighborhood Hits	93	Target Neighborhood Hits	309	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.052410 (rank : 152)
Query Neighborhood Hits	93	Target Neighborhood Hits	310	Shared Neighborhood Hits	5
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.053473 (rank : 146)
Query Neighborhood Hits	93	Target Neighborhood Hits	312	Shared Neighborhood Hits	5
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HSH2D_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.053083 (rank : 149)
Query Neighborhood Hits	93	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ITSN1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.073864 (rank : 108)
Query Neighborhood Hits	93	Target Neighborhood Hits	1757	Shared Neighborhood Hits	65
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.070450 (rank : 115)
Query Neighborhood Hits	93	Target Neighborhood Hits	1669	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.073850 (rank : 109)
Query Neighborhood Hits	93	Target Neighborhood Hits	1173	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.077426 (rank : 101)
Query Neighborhood Hits	93	Target Neighborhood Hits	1371	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LCP2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.057469 (rank : 133)
Query Neighborhood Hits	93	Target Neighborhood Hits	531	Shared Neighborhood Hits	8
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.074448 (rank : 107)
Query Neighborhood Hits	93	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

OTOF_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.092895 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	168	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.091664 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	196	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

P3C2A_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.054675 (rank : 140)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.054199 (rank : 143)
Query Neighborhood Hits	93	Target Neighborhood Hits	181	Shared Neighborhood Hits	40
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.071500 (rank : 113)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P55G_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.054395 (rank : 141)
Query Neighborhood Hits	93	Target Neighborhood Hits	451	Shared Neighborhood Hits	9
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.050361 (rank : 162)
Query Neighborhood Hits	93	Target Neighborhood Hits	401	Shared Neighborhood Hits	7
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.051372 (rank : 157)
Query Neighborhood Hits	93	Target Neighborhood Hits	519	Shared Neighborhood Hits	12
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PA24A_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.066175 (rank : 123)
Query Neighborhood Hits	93	Target Neighborhood Hits	100	Shared Neighborhood Hits	45
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24B_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.056855 (rank : 135)
Query Neighborhood Hits	93	Target Neighborhood Hits	89	Shared Neighborhood Hits	45
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24B_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.068568 (rank : 119)
Query Neighborhood Hits	93	Target Neighborhood Hits	102	Shared Neighborhood Hits	47
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24D_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.069723 (rank : 117)
Query Neighborhood Hits	93	Target Neighborhood Hits	97	Shared Neighborhood Hits	46
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PA24E_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.051877 (rank : 156)
Query Neighborhood Hits	93	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24E_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.059861 (rank : 130)
Query Neighborhood Hits	93	Target Neighborhood Hits	95	Shared Neighborhood Hits	45
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

RASA1_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.069800 (rank : 116)
Query Neighborhood Hits	93	Target Neighborhood Hits	258	Shared Neighborhood Hits	17
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASA2_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.074749 (rank : 106)
Query Neighborhood Hits	93	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.076952 (rank : 103)
Query Neighborhood Hits	93	Target Neighborhood Hits	159	Shared Neighborhood Hits	51
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.076654 (rank : 104)
Query Neighborhood Hits	93	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA3_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.065231 (rank : 125)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	47
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASL1_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.126670 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RFIP2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.077283 (rank : 102)
Query Neighborhood Hits	93	Target Neighborhood Hits	97	Shared Neighborhood Hits	45
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

RIMS1_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.081382 (rank : 96)
Query Neighborhood Hits	93	Target Neighborhood Hits	437	Shared Neighborhood Hits	45
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.083801 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	342	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.082578 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	376	Shared Neighborhood Hits	50
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS3_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.051345 (rank : 158)
Query Neighborhood Hits	93	Target Neighborhood Hits	66	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.062150 (rank : 128)
Query Neighborhood Hits	93	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.062704 (rank : 127)
Query Neighborhood Hits	93	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SH22A_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.072762 (rank : 112)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.064187 (rank : 126)
Query Neighborhood Hits	93	Target Neighborhood Hits	179	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH24A_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.067787 (rank : 120)
Query Neighborhood Hits	93	Target Neighborhood Hits	455	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SHE_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.050540 (rank : 161)
Query Neighborhood Hits	93	Target Neighborhood Hits	164	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.051034 (rank : 159)
Query Neighborhood Hits	93	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SMUF1_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.055956 (rank : 138)
Query Neighborhood Hits	93	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.055749 (rank : 139)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.056742 (rank : 136)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SYT10_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.157410 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT12_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.134306 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	100	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT13_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.126837 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.124639 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	69	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT14_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.118049 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	81	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.120809 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT15_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.136992 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	112	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT15_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.132827 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	100	Shared Neighborhood Hits	45
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYT6_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.153657 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	54
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.154139 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	132	Shared Neighborhood Hits	54
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT8_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.138968 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYTL1_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.118221 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL1_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.109827 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	44
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.114400 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	248	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.112644 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	253	Shared Neighborhood Hits	50
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL3_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.104250 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	110	Shared Neighborhood Hits	43
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.123029 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	48
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.122023 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.118068 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	237	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.115448 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	154	Shared Neighborhood Hits	53
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TAC2N_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.074911 (rank : 105)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.073375 (rank : 110)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

UN13A_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.081004 (rank : 98)
Query Neighborhood Hits	93	Target Neighborhood Hits	285	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.081156 (rank : 97)
Query Neighborhood Hits	93	Target Neighborhood Hits	217	Shared Neighborhood Hits	53
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.087116 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	210	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.052022 (rank : 155)
Query Neighborhood Hits	93	Target Neighborhood Hits	453	Shared Neighborhood Hits	11
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.058519 (rank : 131)
Query Neighborhood Hits	93	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.055972 (rank : 137)
Query Neighborhood Hits	93	Target Neighborhood Hits	404	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.050242 (rank : 163)
Query Neighborhood Hits	93	Target Neighborhood Hits	452	Shared Neighborhood Hits	12
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.050764 (rank : 160)
Query Neighborhood Hits	93	Target Neighborhood Hits	430	Shared Neighborhood Hits	12
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

PLCD1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
NC score	0.989088 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	106	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCB3_MOUSE
NC score	0.778129 (rank : 3)	θ value	8.87376e-48 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCB2_HUMAN
NC score	0.756920 (rank : 4)	θ value	2.91998e-83 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	608	Shared Neighborhood Hits	17
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLCB1_MOUSE
NC score	0.753636 (rank : 5)	θ value	3.56943e-81 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	531	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB3_HUMAN
NC score	0.748116 (rank : 6)	θ value	3.98324e-48 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	445	Shared Neighborhood Hits	14
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCB1_HUMAN
NC score	0.743039 (rank : 7)	θ value	4.21644e-82 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	614	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB4_HUMAN
NC score	0.655236 (rank : 8)	θ value	1.788e-48 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	658	Shared Neighborhood Hits	15
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PLCG2_HUMAN
NC score	0.625746 (rank : 9)	θ value	1.96772e-63 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	280	Shared Neighborhood Hits	25
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_HUMAN
NC score	0.617079 (rank : 10)	θ value	1.08223e-53 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
NC score	0.611318 (rank : 11)	θ value	2.18062e-54 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	26
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DOC2A_MOUSE
NC score	0.210204 (rank : 12)	θ value	0.0330416 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	140	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2A_HUMAN
NC score	0.206067 (rank : 13)	θ value	0.0563607 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	60
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2B_MOUSE
NC score	0.200412 (rank : 14)	θ value	0.00869519 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	169	Shared Neighborhood Hits	59
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_HUMAN
NC score	0.199983 (rank : 15)	θ value	0.0113563 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	59
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

SYT1_HUMAN
NC score	0.195491 (rank : 16)	θ value	0.000270298 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	56
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.195486 (rank : 17)	θ value	0.000270298 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	56
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT7_HUMAN
NC score	0.193353 (rank : 18)	θ value	0.000602161 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
NC score	0.193260 (rank : 19)	θ value	0.000461057 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT5_HUMAN
NC score	0.188725 (rank : 20)	θ value	0.00228821 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	56
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT5_MOUSE
NC score	0.188036 (rank : 21)	θ value	0.00509761 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	140	Shared Neighborhood Hits	57
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT2_MOUSE
NC score	0.184312 (rank : 22)	θ value	0.0113563 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	143	Shared Neighborhood Hits	56
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
NC score	0.183638 (rank : 23)	θ value	0.0193708 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT11_MOUSE
NC score	0.181803 (rank : 24)	θ value	0.00298849 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	116	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
NC score	0.181801 (rank : 25)	θ value	0.00298849 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT3_HUMAN
NC score	0.173379 (rank : 26)	θ value	0.0961366 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	145	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
NC score	0.173200 (rank : 27)	θ value	0.125558 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	147	Shared Neighborhood Hits	56
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

RP3A_HUMAN
NC score	0.172219 (rank : 28)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	305	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
NC score	0.171811 (rank : 29)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	510	Shared Neighborhood Hits	57
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT4_HUMAN
NC score	0.170822 (rank : 30)	θ value	0.62314 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	121	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

DOC2G_MOUSE
NC score	0.170290 (rank : 31)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT4_MOUSE
NC score	0.168679 (rank : 32)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	123	Shared Neighborhood Hits	52
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

RASL2_HUMAN
NC score	0.164242 (rank : 33)	θ value	0.00665767 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	161	Shared Neighborhood Hits	56
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

SYT9_HUMAN
NC score	0.161433 (rank : 34)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	56
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
NC score	0.161038 (rank : 35)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

K0528_HUMAN
NC score	0.157497 (rank : 36)	θ value	0.163984 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

SYT10_HUMAN
NC score	0.157410 (rank : 37)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_MOUSE
NC score	0.157324 (rank : 38)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	133	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

K0528_MOUSE
NC score	0.157216 (rank : 39)	θ value	0.163984 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	102	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

SYT6_MOUSE
NC score	0.154139 (rank : 40)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	93	Target Neighborhood Hits	132	Shared Neighborhood Hits	54
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_HUMAN
NC score	0.153657 (rank : 41)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	54
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

BAIP3_HUMAN
NC score	0.146076 (rank : 42)	θ value	0.47712 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	108	Shared Neighborhood Hits	50
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
NC score	0.141602 (rank : 43)	θ value	1.38821 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	112	Shared Neighborhood Hits	51
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

MYOF_HUMAN
NC score	0.141288 (rank : 44)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	147	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

SYT8_MOUSE
NC score	0.138968 (rank : 45)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYT12_MOUSE
NC score	0.137192 (rank : 46)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	102	Shared Neighborhood Hits	46
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT15_HUMAN
NC score	0.136992 (rank : 47)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	93	Target Neighborhood Hits	112	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

UN13D_HUMAN
NC score	0.135838 (rank : 48)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	52
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

RASL1_HUMAN
NC score	0.135709 (rank : 49)	θ value	0.163984 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	57
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

SYT12_HUMAN
NC score	0.134306 (rank : 50)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	93	Target Neighborhood Hits	100	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT15_MOUSE
NC score	0.132827 (rank : 51)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	93	Target Neighborhood Hits	100	Shared Neighborhood Hits	45
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

NED4L_HUMAN
NC score	0.131749 (rank : 52)	θ value	0.000461057 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	238	Shared Neighborhood Hits	58
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.130623 (rank : 53)	θ value	0.000461057 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	231	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

DYSF_MOUSE
NC score	0.130611 (rank : 54)	θ value	0.0193708 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

SYT13_HUMAN
NC score	0.126837 (rank : 55)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	93	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

RASL1_MOUSE
NC score	0.126670 (rank : 56)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

SYT13_MOUSE
NC score	0.124639 (rank : 57)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	93	Target Neighborhood Hits	69	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYTL4_HUMAN
NC score	0.123029 (rank : 58)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	48
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
NC score	0.122023 (rank : 59)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYT14_MOUSE
NC score	0.120809 (rank : 60)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

FA62A_MOUSE
NC score	0.120326 (rank : 61)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	93	Target Neighborhood Hits	155	Shared Neighborhood Hits	54
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_HUMAN
NC score	0.118789 (rank : 62)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	93	Target Neighborhood Hits	168	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL1_HUMAN
NC score	0.118221 (rank : 63)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL5_HUMAN
NC score	0.118068 (rank : 64)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	93	Target Neighborhood Hits	237	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYT14_HUMAN
NC score	0.118049 (rank : 65)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	93	Target Neighborhood Hits	81	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

NEDD4_MOUSE
NC score	0.116997 (rank : 66)	θ value	0.00509761 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	212	Shared Neighborhood Hits	55
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PA24D_MOUSE
NC score	0.115717 (rank : 67)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	100	Shared Neighborhood Hits	51
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

SYTL5_MOUSE
NC score	0.115448 (rank : 68)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	93	Target Neighborhood Hits	154	Shared Neighborhood Hits	53
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

NEDD4_HUMAN
NC score	0.114560 (rank : 69)	θ value	0.00869519 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	214	Shared Neighborhood Hits	55
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

SYTL2_HUMAN
NC score	0.114400 (rank : 70)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	93	Target Neighborhood Hits	248	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

CPNE6_MOUSE
NC score	0.112916 (rank : 71)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	87	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

SYTL2_MOUSE
NC score	0.112644 (rank : 72)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	93	Target Neighborhood Hits	253	Shared Neighborhood Hits	50
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

AB2BP_MOUSE
NC score	0.112551 (rank : 73)	θ value	0.00869519 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D6J4, Q3TYZ9, Q9ESR0	Gene names	Apba2bp, Xb51
Domain Architecture
Description	Amyloid beta A4 protein-binding family A member 2-binding protein (X11L-binding protein 51) (mXB51).

DYSF_HUMAN
NC score	0.110793 (rank : 74)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	56
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

CPNE6_HUMAN
NC score	0.110007 (rank : 75)	θ value	0.00228821 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	85	Shared Neighborhood Hits	46
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

SYTL1_MOUSE
NC score	0.109827 (rank : 76)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	44
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

AB2BP_HUMAN
NC score	0.105803 (rank : 77)	θ value	0.0148317 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q96P71, Q5JWF6, Q5JWF7, Q86VV1, Q9H433, Q9H8G8, Q9HBW7, Q9HCQ9	Gene names	APBA2BP, NECAB3, NIP1, XB51
Domain Architecture
Description	Amyloid beta A4 protein-binding family A member 2-binding protein (Neuronal calcium-binding protein 3) (NECAB 3) (X11L-binding protein 51) (Nek2-interacting protein 1).

SYTL3_MOUSE
NC score	0.104250 (rank : 78)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	93	Target Neighborhood Hits	110	Shared Neighborhood Hits	43
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

PCLO_HUMAN
NC score	0.097721 (rank : 79)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	2046	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
NC score	0.094518 (rank : 80)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	2275	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SEGN_MOUSE
NC score	0.094152 (rank : 81)	θ value	0.00228821 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q91WD9	Gene names	Scgn
Domain Architecture
Description	Secretagogin.

OTOF_HUMAN
NC score	0.092895 (rank : 82)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	93	Target Neighborhood Hits	168	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
NC score	0.091664 (rank : 83)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	93	Target Neighborhood Hits	196	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

CPNE7_HUMAN
NC score	0.089920 (rank : 84)	θ value	0.279714 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

UN13B_MOUSE
NC score	0.087116 (rank : 85)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	93	Target Neighborhood Hits	210	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CPNE2_HUMAN
NC score	0.087010 (rank : 86)	θ value	1.38821 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	75	Shared Neighborhood Hits	47
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE2_MOUSE
NC score	0.086164 (rank : 87)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	48
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE3_MOUSE
NC score	0.086135 (rank : 88)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	93	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE3_HUMAN
NC score	0.085067 (rank : 89)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	93	Target Neighborhood Hits	90	Shared Neighborhood Hits	46
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

RIMS2_HUMAN
NC score	0.083801 (rank : 90)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	93	Target Neighborhood Hits	342	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.082578 (rank : 91)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	93	Target Neighborhood Hits	376	Shared Neighborhood Hits	50
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

CPNE8_HUMAN
NC score	0.081956 (rank : 92)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	86	Shared Neighborhood Hits	48
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

SEGN_HUMAN
NC score	0.081930 (rank : 93)	θ value	0.0113563 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	O76038, Q5VV44, Q96QV7, Q9UJF6	Gene names	SCGN, SECRET
Domain Architecture
Description	Secretagogin.

CPNE5_MOUSE
NC score	0.081900 (rank : 94)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	93	Target Neighborhood Hits	86	Shared Neighborhood Hits	47
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_HUMAN
NC score	0.081611 (rank : 95)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	93	Target Neighborhood Hits	88	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

RIMS1_HUMAN
NC score	0.081382 (rank : 96)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	93	Target Neighborhood Hits	437	Shared Neighborhood Hits	45
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

UN13B_HUMAN
NC score	0.081156 (rank : 97)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	93	Target Neighborhood Hits	217	Shared Neighborhood Hits	53
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13A_HUMAN
NC score	0.081004 (rank : 98)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	93	Target Neighborhood Hits	285	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

CPNE1_MOUSE
NC score	0.079170 (rank : 99)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	93	Target Neighborhood Hits	83	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE8_MOUSE
NC score	0.078753 (rank : 100)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	93	Target Neighborhood Hits	85	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

ITSN2_MOUSE
NC score	0.077426 (rank : 101)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	93	Target Neighborhood Hits	1371	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

RFIP2_HUMAN
NC score	0.077283 (rank : 102)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	93	Target Neighborhood Hits	97	Shared Neighborhood Hits	45
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

RASA2_MOUSE
NC score	0.076952 (rank : 103)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	93	Target Neighborhood Hits	159	Shared Neighborhood Hits	51
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_HUMAN
NC score	0.076654 (rank : 104)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	93	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

TAC2N_HUMAN
NC score	0.074911 (rank : 105)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

RASA2_HUMAN
NC score	0.074749 (rank : 106)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	93	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

LCP2_MOUSE
NC score	0.074448 (rank : 107)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	93	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

ITSN1_HUMAN
NC score	0.073864 (rank : 108)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	93	Target Neighborhood Hits	1757	Shared Neighborhood Hits	65
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_HUMAN
NC score	0.073850 (rank : 109)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	93	Target Neighborhood Hits	1173	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

TAC2N_MOUSE
NC score	0.073375 (rank : 110)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

CALU_MOUSE
NC score	0.072908 (rank : 111)	θ value	0.0193708 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	O35887	Gene names	Calu
Domain Architecture
Description	Calumenin precursor (Crocalbin).

SH22A_HUMAN
NC score	0.072762 (rank : 112)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

P3C2B_HUMAN
NC score	0.071500 (rank : 113)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

CPNE1_HUMAN
NC score	0.071450 (rank : 114)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	93	Target Neighborhood Hits	70	Shared Neighborhood Hits	44
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

ITSN1_MOUSE
NC score	0.070450 (rank : 115)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	93	Target Neighborhood Hits	1669	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RASA1_HUMAN
NC score	0.069800 (rank : 116)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	93	Target Neighborhood Hits	258	Shared Neighborhood Hits	17
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PA24D_HUMAN
NC score	0.069723 (rank : 117)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	93	Target Neighborhood Hits	97	Shared Neighborhood Hits	46
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

CALU_HUMAN
NC score	0.068993 (rank : 118)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	114	Shared Neighborhood Hits	8
SwissProt Accessions	O43852, O60456, Q6FHB9, Q96RL3, Q9NR43	Gene names	CALU
Domain Architecture
Description	Calumenin precursor (Crocalbin) (IEF SSP 9302).

PA24B_MOUSE
NC score	0.068568 (rank : 119)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	93	Target Neighborhood Hits	102	Shared Neighborhood Hits	47
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

SH24A_HUMAN
NC score	0.067787 (rank : 120)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	93	Target Neighborhood Hits	455	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

CPNE4_HUMAN
NC score	0.067210 (rank : 121)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	93	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
NC score	0.066980 (rank : 122)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

PA24A_MOUSE
NC score	0.066175 (rank : 123)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	93	Target Neighborhood Hits	100	Shared Neighborhood Hits	45
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

DAPP1_MOUSE
NC score	0.065341 (rank : 124)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	93	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

RASA3_MOUSE
NC score	0.065231 (rank : 125)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	47
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

SH22A_MOUSE
NC score	0.064187 (rank : 126)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	93	Target Neighborhood Hits	179	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

RIMS4_MOUSE
NC score	0.062704 (rank : 127)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	93	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.062150 (rank : 128)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	93	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

DAPP1_HUMAN
NC score	0.060246 (rank : 129)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PA24E_MOUSE
NC score	0.059861 (rank : 130)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	93	Target Neighborhood Hits	95	Shared Neighborhood Hits	45
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

VAV3_HUMAN
NC score	0.058519 (rank : 131)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	93	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

KPCG_MOUSE
NC score	0.057690 (rank : 132)	θ value	0.0252991 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	1123	Shared Neighborhood Hits	59
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

LCP2_HUMAN
NC score	0.057469 (rank : 133)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	93	Target Neighborhood Hits	531	Shared Neighborhood Hits	8
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

KPCG_HUMAN
NC score	0.057352 (rank : 134)	θ value	0.0193708 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	1126	Shared Neighborhood Hits	59
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PA24B_HUMAN
NC score	0.056855 (rank : 135)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	93	Target Neighborhood Hits	89	Shared Neighborhood Hits	45
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

SMUF2_HUMAN
NC score	0.056742 (rank : 136)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

VAV3_MOUSE
NC score	0.055972 (rank : 137)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	93	Target Neighborhood Hits	404	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SMUF1_HUMAN
NC score	0.055956 (rank : 138)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	93	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.055749 (rank : 139)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

P3C2A_HUMAN
NC score	0.054675 (rank : 140)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P55G_HUMAN
NC score	0.054395 (rank : 141)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	93	Target Neighborhood Hits	451	Shared Neighborhood Hits	9
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

KPCA_MOUSE
NC score	0.054210 (rank : 142)	θ value	0.0252991 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	1067	Shared Neighborhood Hits	61
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

P3C2A_MOUSE
NC score	0.054199 (rank : 143)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	93	Target Neighborhood Hits	181	Shared Neighborhood Hits	40
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

APS_HUMAN
NC score	0.053981 (rank : 144)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GRAP_MOUSE
NC score	0.053646 (rank : 145)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	93	Target Neighborhood Hits	309	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_MOUSE
NC score	0.053473 (rank : 146)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	93	Target Neighborhood Hits	312	Shared Neighborhood Hits	5
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

CRK_HUMAN
NC score	0.053408 (rank : 147)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	93	Target Neighborhood Hits	308	Shared Neighborhood Hits	5
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

KPCB_MOUSE
NC score	0.053154 (rank : 148)	θ value	0.21417 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	1117	Shared Neighborhood Hits	61
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

HSH2D_MOUSE
NC score	0.053083 (rank : 149)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	93	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

KPCA_HUMAN
NC score	0.052609 (rank : 150)	θ value	0.0736092 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	1070	Shared Neighborhood Hits	60
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
NC score	0.052485 (rank : 151)	θ value	0.21417 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	1121	Shared Neighborhood Hits	61
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

GRB2_HUMAN
NC score	0.052410 (rank : 152)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	93	Target Neighborhood Hits	310	Shared Neighborhood Hits	5
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

CRK_MOUSE
NC score	0.052240 (rank : 153)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	5
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRAP_HUMAN
NC score	0.052060 (rank : 154)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	93	Target Neighborhood Hits	307	Shared Neighborhood Hits	5
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

VAV2_HUMAN
NC score	0.052022 (rank : 155)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	93	Target Neighborhood Hits	453	Shared Neighborhood Hits	11
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PA24E_HUMAN
NC score	0.051877 (rank : 156)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	93	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

P85B_MOUSE
NC score	0.051372 (rank : 157)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	93	Target Neighborhood Hits	519	Shared Neighborhood Hits	12
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

RIMS3_HUMAN
NC score	0.051345 (rank : 158)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	93	Target Neighborhood Hits	66	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SHE_MOUSE
NC score	0.051034 (rank : 159)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	93	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

VAV_MOUSE
NC score	0.050764 (rank : 160)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	93	Target Neighborhood Hits	430	Shared Neighborhood Hits	12
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SHE_HUMAN
NC score	0.050540 (rank : 161)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	93	Target Neighborhood Hits	164	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

P55G_MOUSE
NC score	0.050361 (rank : 162)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	93	Target Neighborhood Hits	401	Shared Neighborhood Hits	7
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

VAV_HUMAN
NC score	0.050242 (rank : 163)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	93	Target Neighborhood Hits	452	Shared Neighborhood Hits	12
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CAB45_MOUSE
NC score	0.049706 (rank : 164)	θ value	0.279714 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q61112, Q61113	Gene names	Sdf4, Cab45
Domain Architecture	No domain graphic available
Description	45 kDa calcium-binding protein precursor (Cab45) (Stromal cell-derived factor 4) (SDF-4).

CU013_HUMAN
NC score	0.045270 (rank : 165)	θ value	0.47712 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	405	Shared Neighborhood Hits	8
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

CAB45_HUMAN
NC score	0.040561 (rank : 166)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BRK5, Q8NBQ3, Q9NZP7	Gene names	SDF4, CAB45
Domain Architecture
Description	45 kDa calcium-binding protein precursor (Cab45) (Stromal cell-derived factor 4) (SDF-4).

TEX15_HUMAN
NC score	0.037782 (rank : 167)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXT5	Gene names	TEX15
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 15 protein.

CALB2_HUMAN
NC score	0.034771 (rank : 168)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	149	Shared Neighborhood Hits	7
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

CALB2_MOUSE
NC score	0.031741 (rank : 169)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	141	Shared Neighborhood Hits	6
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

MCM8_HUMAN
NC score	0.031181 (rank : 170)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

CYLD_MOUSE
NC score	0.028344 (rank : 171)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

CYLD_HUMAN
NC score	0.027177 (rank : 172)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQC7, O94934, Q7L3N6, Q96EH0, Q9NZX9	Gene names	CYLD, CYLD1, KIAA0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

KNTC2_MOUSE
NC score	0.025827 (rank : 173)	θ value	0.47712 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	692	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

PLSI_HUMAN
NC score	0.020308 (rank : 174)	θ value	1.38821 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	209	Shared Neighborhood Hits	11
SwissProt Accessions	Q14651	Gene names	PLS1
Domain Architecture
Description	Plastin-1 (I-plastin) (Intestine-specific plastin).

MCM8_MOUSE
NC score	0.019431 (rank : 175)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

NCOR2_HUMAN
NC score	0.018718 (rank : 176)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	870	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

TEC_HUMAN
NC score	0.016874 (rank : 177)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	1006	Shared Neighborhood Hits	16
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TF2LY_HUMAN
NC score	0.016639 (rank : 178)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IUE0	Gene names	TGIF2LY, TGIFLY
Domain Architecture
Description	Homeobox protein TGIF2LY (TGFB-induced factor 2-like protein, Y- linked) (TGF(beta)induced transcription factor 2-like protein) (TGIF- like on the Y).

TEC_MOUSE
NC score	0.016382 (rank : 179)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	1006	Shared Neighborhood Hits	16
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ROCK1_HUMAN
NC score	0.016089 (rank : 180)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	2000	Shared Neighborhood Hits	21
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

KNTC2_HUMAN
NC score	0.013567 (rank : 181)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	673	Shared Neighborhood Hits	6
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

NSF1C_MOUSE
NC score	0.012543 (rank : 182)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZ44, Q80Y15, Q8BYL3	Gene names	Nsfl1c
Domain Architecture
Description	NSFL1 cofactor p47 (p97 cofactor p47).

EFHC1_HUMAN
NC score	0.012279 (rank : 183)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q5JVL4, Q5XKM4, Q6E1U7, Q6E1U8, Q8WUL2, Q9NVW6	Gene names	EFHC1
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing protein 1.

LX12E_MOUSE
NC score	0.005980 (rank : 184)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	P55249, Q91YW6	Gene names	Alox12e, Alox12-ps2, Aloxe
Domain Architecture
Description	Arachidonate 12-lipoxygenase, epidermal-type (EC 1.13.11.31) (12-LOX).

TGFB2_MOUSE
NC score	0.003354 (rank : 185)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	P27090	Gene names	Tgfb2
Domain Architecture
Description	Transforming growth factor beta-2 precursor (TGF-beta-2).