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Network neighborhood for query Sequence : UN13B_HUMAN

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UN13B_HUMAN
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UN13A_HUMAN
θ value	0 (rank : 1)	NC score	0.981221 (rank : 3)
Query Neighborhood Hits	217	Target Neighborhood Hits	285	Shared Neighborhood Hits	192
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	217	Target Neighborhood Hits	217	Shared Neighborhood Hits	217
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	0 (rank : 3)	NC score	0.995018 (rank : 2)
Query Neighborhood Hits	217	Target Neighborhood Hits	210	Shared Neighborhood Hits	191
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13D_HUMAN
θ value	1.85889e-29 (rank : 4)	NC score	0.598864 (rank : 4)
Query Neighborhood Hits	217	Target Neighborhood Hits	117	Shared Neighborhood Hits	88
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

BAIP3_HUMAN
θ value	2.87452e-22 (rank : 5)	NC score	0.566815 (rank : 5)
Query Neighborhood Hits	217	Target Neighborhood Hits	108	Shared Neighborhood Hits	78
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
θ value	5.99374e-20 (rank : 6)	NC score	0.543478 (rank : 6)
Query Neighborhood Hits	217	Target Neighborhood Hits	112	Shared Neighborhood Hits	89
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

KPCG_MOUSE
θ value	4.02038e-16 (rank : 7)	NC score	0.274916 (rank : 66)
Query Neighborhood Hits	217	Target Neighborhood Hits	1123	Shared Neighborhood Hits	172
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
θ value	2.60593e-15 (rank : 8)	NC score	0.274139 (rank : 67)
Query Neighborhood Hits	217	Target Neighborhood Hits	1126	Shared Neighborhood Hits	173
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCA_MOUSE
θ value	1.29331e-14 (rank : 9)	NC score	0.263562 (rank : 75)
Query Neighborhood Hits	217	Target Neighborhood Hits	1067	Shared Neighborhood Hits	175
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	3.76295e-14 (rank : 10)	NC score	0.266678 (rank : 72)
Query Neighborhood Hits	217	Target Neighborhood Hits	1121	Shared Neighborhood Hits	170
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	4.91457e-14 (rank : 11)	NC score	0.267408 (rank : 71)
Query Neighborhood Hits	217	Target Neighborhood Hits	1117	Shared Neighborhood Hits	170
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCA_HUMAN
θ value	6.41864e-14 (rank : 12)	NC score	0.265198 (rank : 73)
Query Neighborhood Hits	217	Target Neighborhood Hits	1070	Shared Neighborhood Hits	175
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

GRP3_HUMAN
θ value	2.0648e-12 (rank : 13)	NC score	0.448884 (rank : 7)
Query Neighborhood Hits	217	Target Neighborhood Hits	131	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

KPCT_HUMAN
θ value	9.59137e-10 (rank : 14)	NC score	0.178150 (rank : 144)
Query Neighborhood Hits	217	Target Neighborhood Hits	897	Shared Neighborhood Hits	76
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	9.59137e-10 (rank : 15)	NC score	0.178612 (rank : 143)
Query Neighborhood Hits	217	Target Neighborhood Hits	895	Shared Neighborhood Hits	76
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCD_MOUSE
θ value	1.63604e-09 (rank : 16)	NC score	0.183882 (rank : 133)
Query Neighborhood Hits	217	Target Neighborhood Hits	888	Shared Neighborhood Hits	78
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

NEDD4_HUMAN
θ value	2.13673e-09 (rank : 17)	NC score	0.298702 (rank : 55)
Query Neighborhood Hits	217	Target Neighborhood Hits	214	Shared Neighborhood Hits	106
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

KPCD_HUMAN
θ value	4.76016e-09 (rank : 18)	NC score	0.182178 (rank : 137)
Query Neighborhood Hits	217	Target Neighborhood Hits	900	Shared Neighborhood Hits	78
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD3_HUMAN
θ value	8.11959e-09 (rank : 19)	NC score	0.153715 (rank : 162)
Query Neighborhood Hits	217	Target Neighborhood Hits	895	Shared Neighborhood Hits	76
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

NED4L_HUMAN
θ value	8.11959e-09 (rank : 20)	NC score	0.316551 (rank : 44)
Query Neighborhood Hits	217	Target Neighborhood Hits	238	Shared Neighborhood Hits	112
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	8.11959e-09 (rank : 21)	NC score	0.315169 (rank : 46)
Query Neighborhood Hits	217	Target Neighborhood Hits	231	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
θ value	1.38499e-08 (rank : 22)	NC score	0.293193 (rank : 57)
Query Neighborhood Hits	217	Target Neighborhood Hits	212	Shared Neighborhood Hits	106
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

KPCD2_HUMAN
θ value	3.08544e-08 (rank : 23)	NC score	0.145520 (rank : 168)
Query Neighborhood Hits	217	Target Neighborhood Hits	910	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

CHIO_HUMAN
θ value	4.0297e-08 (rank : 24)	NC score	0.311995 (rank : 47)
Query Neighborhood Hits	217	Target Neighborhood Hits	220	Shared Neighborhood Hits	73
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_MOUSE
θ value	5.26297e-08 (rank : 25)	NC score	0.307992 (rank : 52)
Query Neighborhood Hits	217	Target Neighborhood Hits	229	Shared Neighborhood Hits	73
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_MOUSE
θ value	5.26297e-08 (rank : 26)	NC score	0.321997 (rank : 41)
Query Neighborhood Hits	217	Target Neighborhood Hits	130	Shared Neighborhood Hits	72
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

KPCD3_MOUSE
θ value	5.26297e-08 (rank : 27)	NC score	0.148575 (rank : 163)
Query Neighborhood Hits	217	Target Neighborhood Hits	901	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

CHIN_HUMAN
θ value	6.87365e-08 (rank : 28)	NC score	0.307417 (rank : 53)
Query Neighborhood Hits	217	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

KPCL_MOUSE
θ value	6.87365e-08 (rank : 29)	NC score	0.181167 (rank : 142)
Query Neighborhood Hits	217	Target Neighborhood Hits	891	Shared Neighborhood Hits	94
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_HUMAN
θ value	8.97725e-08 (rank : 30)	NC score	0.181550 (rank : 141)
Query Neighborhood Hits	217	Target Neighborhood Hits	887	Shared Neighborhood Hits	90
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

RASL1_HUMAN
θ value	8.97725e-08 (rank : 31)	NC score	0.422022 (rank : 11)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	107
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	8.97725e-08 (rank : 32)	NC score	0.432756 (rank : 9)
Query Neighborhood Hits	217	Target Neighborhood Hits	161	Shared Neighborhood Hits	109
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

FA62A_MOUSE
θ value	1.99992e-07 (rank : 33)	NC score	0.443534 (rank : 8)
Query Neighborhood Hits	217	Target Neighborhood Hits	155	Shared Neighborhood Hits	110
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

KPCD1_HUMAN
θ value	1.99992e-07 (rank : 34)	NC score	0.144485 (rank : 169)
Query Neighborhood Hits	217	Target Neighborhood Hits	901	Shared Neighborhood Hits	76
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCE_HUMAN
θ value	1.99992e-07 (rank : 35)	NC score	0.184957 (rank : 129)
Query Neighborhood Hits	217	Target Neighborhood Hits	906	Shared Neighborhood Hits	93
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
θ value	1.99992e-07 (rank : 36)	NC score	0.184698 (rank : 130)
Query Neighborhood Hits	217	Target Neighborhood Hits	906	Shared Neighborhood Hits	93
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

CAPS2_HUMAN
θ value	2.61198e-07 (rank : 37)	NC score	0.176608 (rank : 147)
Query Neighborhood Hits	217	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q86UW7, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8	Gene names	CADPS2, CAPS2, KIAA1591
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

CAPS2_MOUSE
θ value	2.61198e-07 (rank : 38)	NC score	0.181965 (rank : 139)
Query Neighborhood Hits	217	Target Neighborhood Hits	78	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BYR5, O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8K3K6	Gene names	Cadps2, Caps2
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

KPCD1_MOUSE
θ value	2.61198e-07 (rank : 39)	NC score	0.144006 (rank : 171)
Query Neighborhood Hits	217	Target Neighborhood Hits	891	Shared Neighborhood Hits	76
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

RASL1_MOUSE
θ value	3.41135e-07 (rank : 40)	NC score	0.410613 (rank : 12)
Query Neighborhood Hits	217	Target Neighborhood Hits	148	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASF1_MOUSE
θ value	9.92553e-07 (rank : 41)	NC score	0.377681 (rank : 26)
Query Neighborhood Hits	217	Target Neighborhood Hits	74	Shared Neighborhood Hits	60
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

PA24B_MOUSE
θ value	2.21117e-06 (rank : 42)	NC score	0.318190 (rank : 43)
Query Neighborhood Hits	217	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

MRCKA_HUMAN
θ value	2.88788e-06 (rank : 43)	NC score	0.147365 (rank : 166)
Query Neighborhood Hits	217	Target Neighborhood Hits	1999	Shared Neighborhood Hits	90
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

RIMS2_HUMAN
θ value	2.88788e-06 (rank : 44)	NC score	0.322087 (rank : 40)
Query Neighborhood Hits	217	Target Neighborhood Hits	342	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	2.88788e-06 (rank : 45)	NC score	0.318675 (rank : 42)
Query Neighborhood Hits	217	Target Neighborhood Hits	376	Shared Neighborhood Hits	96
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SYT6_MOUSE
θ value	2.88788e-06 (rank : 46)	NC score	0.385823 (rank : 20)
Query Neighborhood Hits	217	Target Neighborhood Hits	132	Shared Neighborhood Hits	106
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

FA62A_HUMAN
θ value	3.77169e-06 (rank : 47)	NC score	0.429873 (rank : 10)
Query Neighborhood Hits	217	Target Neighborhood Hits	168	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

PCLO_HUMAN
θ value	4.92598e-06 (rank : 48)	NC score	0.293187 (rank : 58)
Query Neighborhood Hits	217	Target Neighborhood Hits	2046	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYT6_HUMAN
θ value	4.92598e-06 (rank : 49)	NC score	0.384350 (rank : 23)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	106
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

MRCKB_HUMAN
θ value	6.43352e-06 (rank : 50)	NC score	0.142791 (rank : 174)
Query Neighborhood Hits	217	Target Neighborhood Hits	2239	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

RFIP2_HUMAN
θ value	6.43352e-06 (rank : 51)	NC score	0.363247 (rank : 33)
Query Neighborhood Hits	217	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

DOC2B_HUMAN
θ value	1.09739e-05 (rank : 52)	NC score	0.404190 (rank : 13)
Query Neighborhood Hits	217	Target Neighborhood Hits	150	Shared Neighborhood Hits	112
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

MRCKB_MOUSE
θ value	1.09739e-05 (rank : 53)	NC score	0.144329 (rank : 170)
Query Neighborhood Hits	217	Target Neighborhood Hits	2180	Shared Neighborhood Hits	89
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

RIMS1_HUMAN
θ value	1.09739e-05 (rank : 54)	NC score	0.301013 (rank : 54)
Query Neighborhood Hits	217	Target Neighborhood Hits	437	Shared Neighborhood Hits	84
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RP3A_MOUSE
θ value	1.09739e-05 (rank : 55)	NC score	0.386875 (rank : 17)
Query Neighborhood Hits	217	Target Neighborhood Hits	510	Shared Neighborhood Hits	111
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT10_HUMAN
θ value	1.09739e-05 (rank : 56)	NC score	0.385019 (rank : 21)
Query Neighborhood Hits	217	Target Neighborhood Hits	134	Shared Neighborhood Hits	107
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_MOUSE
θ value	1.09739e-05 (rank : 57)	NC score	0.383932 (rank : 24)
Query Neighborhood Hits	217	Target Neighborhood Hits	133	Shared Neighborhood Hits	106
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

PA24B_HUMAN
θ value	1.43324e-05 (rank : 58)	NC score	0.279046 (rank : 63)
Query Neighborhood Hits	217	Target Neighborhood Hits	89	Shared Neighborhood Hits	72
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24D_MOUSE
θ value	1.43324e-05 (rank : 59)	NC score	0.332074 (rank : 38)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	87
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

CPNE2_HUMAN
θ value	2.44474e-05 (rank : 60)	NC score	0.246113 (rank : 92)
Query Neighborhood Hits	217	Target Neighborhood Hits	75	Shared Neighborhood Hits	70
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE2_MOUSE
θ value	3.19293e-05 (rank : 61)	NC score	0.246315 (rank : 91)
Query Neighborhood Hits	217	Target Neighborhood Hits	82	Shared Neighborhood Hits	71
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

KPCI_HUMAN
θ value	3.19293e-05 (rank : 62)	NC score	0.159613 (rank : 159)
Query Neighborhood Hits	217	Target Neighborhood Hits	885	Shared Neighborhood Hits	74
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	3.19293e-05 (rank : 63)	NC score	0.159524 (rank : 160)
Query Neighborhood Hits	217	Target Neighborhood Hits	888	Shared Neighborhood Hits	76
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

PA24D_HUMAN
θ value	3.19293e-05 (rank : 64)	NC score	0.310197 (rank : 50)
Query Neighborhood Hits	217	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RFIP1_HUMAN
θ value	3.19293e-05 (rank : 65)	NC score	0.223045 (rank : 111)
Query Neighborhood Hits	217	Target Neighborhood Hits	236	Shared Neighborhood Hits	43
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

KPCZ_HUMAN
θ value	5.44631e-05 (rank : 66)	NC score	0.164317 (rank : 156)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	76
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

RP3A_HUMAN
θ value	5.44631e-05 (rank : 67)	NC score	0.384980 (rank : 22)
Query Neighborhood Hits	217	Target Neighborhood Hits	305	Shared Neighborhood Hits	111
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT7_HUMAN
θ value	5.44631e-05 (rank : 68)	NC score	0.386501 (rank : 18)
Query Neighborhood Hits	217	Target Neighborhood Hits	137	Shared Neighborhood Hits	106
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
θ value	5.44631e-05 (rank : 69)	NC score	0.386282 (rank : 19)
Query Neighborhood Hits	217	Target Neighborhood Hits	137	Shared Neighborhood Hits	108
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

PCLO_MOUSE
θ value	7.1131e-05 (rank : 70)	NC score	0.269595 (rank : 70)
Query Neighborhood Hits	217	Target Neighborhood Hits	2275	Shared Neighborhood Hits	125
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYT9_MOUSE
θ value	7.1131e-05 (rank : 71)	NC score	0.380040 (rank : 25)
Query Neighborhood Hits	217	Target Neighborhood Hits	148	Shared Neighborhood Hits	108
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

RFIP1_MOUSE
θ value	9.29e-05 (rank : 72)	NC score	0.236703 (rank : 101)
Query Neighborhood Hits	217	Target Neighborhood Hits	152	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

DGKQ_HUMAN
θ value	0.000121331 (rank : 73)	NC score	0.295984 (rank : 56)
Query Neighborhood Hits	217	Target Neighborhood Hits	131	Shared Neighborhood Hits	71
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

RASF1_HUMAN
θ value	0.000121331 (rank : 74)	NC score	0.322810 (rank : 39)
Query Neighborhood Hits	217	Target Neighborhood Hits	62	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

SYT9_HUMAN
θ value	0.000121331 (rank : 75)	NC score	0.377487 (rank : 27)
Query Neighborhood Hits	217	Target Neighborhood Hits	144	Shared Neighborhood Hits	107
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

DOC2A_HUMAN
θ value	0.00020696 (rank : 76)	NC score	0.396174 (rank : 15)
Query Neighborhood Hits	217	Target Neighborhood Hits	144	Shared Neighborhood Hits	108
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	0.00020696 (rank : 77)	NC score	0.393907 (rank : 16)
Query Neighborhood Hits	217	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_MOUSE
θ value	0.00020696 (rank : 78)	NC score	0.396340 (rank : 14)
Query Neighborhood Hits	217	Target Neighborhood Hits	169	Shared Neighborhood Hits	112
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

KPCZ_MOUSE
θ value	0.00020696 (rank : 79)	NC score	0.162476 (rank : 158)
Query Neighborhood Hits	217	Target Neighborhood Hits	882	Shared Neighborhood Hits	75
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

SMUF1_HUMAN
θ value	0.00020696 (rank : 80)	NC score	0.190734 (rank : 124)
Query Neighborhood Hits	217	Target Neighborhood Hits	135	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	0.00020696 (rank : 81)	NC score	0.189570 (rank : 125)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	72
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

MRCKG_MOUSE
θ value	0.000461057 (rank : 82)	NC score	0.145618 (rank : 167)
Query Neighborhood Hits	217	Target Neighborhood Hits	1466	Shared Neighborhood Hits	78
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

RASA3_HUMAN
θ value	0.000461057 (rank : 83)	NC score	0.262340 (rank : 77)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	76
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASF5_MOUSE
θ value	0.000461057 (rank : 84)	NC score	0.220235 (rank : 114)
Query Neighborhood Hits	217	Target Neighborhood Hits	72	Shared Neighborhood Hits	47
SwissProt Accessions	Q5EBH1, O70407, Q6KAR0, Q8C2E8	Gene names	Rassf5, Nore1, Rapl
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

MRCKG_HUMAN
θ value	0.00102713 (rank : 85)	NC score	0.142962 (rank : 173)
Query Neighborhood Hits	217	Target Neighborhood Hits	1519	Shared Neighborhood Hits	76
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PA24F_MOUSE
θ value	0.00102713 (rank : 86)	NC score	0.239099 (rank : 97)
Query Neighborhood Hits	217	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

SYT1_HUMAN
θ value	0.00102713 (rank : 87)	NC score	0.371004 (rank : 29)
Query Neighborhood Hits	217	Target Neighborhood Hits	150	Shared Neighborhood Hits	110
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	0.00102713 (rank : 88)	NC score	0.371001 (rank : 30)
Query Neighborhood Hits	217	Target Neighborhood Hits	150	Shared Neighborhood Hits	110
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

VAV2_HUMAN
θ value	0.00175202 (rank : 89)	NC score	0.181691 (rank : 140)
Query Neighborhood Hits	217	Target Neighborhood Hits	453	Shared Neighborhood Hits	65
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
θ value	0.00175202 (rank : 90)	NC score	0.175058 (rank : 149)
Query Neighborhood Hits	217	Target Neighborhood Hits	404	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	0.00175202 (rank : 91)	NC score	0.177161 (rank : 145)
Query Neighborhood Hits	217	Target Neighborhood Hits	452	Shared Neighborhood Hits	72
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SMUF2_HUMAN
θ value	0.00228821 (rank : 92)	NC score	0.181995 (rank : 138)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

DYSF_HUMAN
θ value	0.00298849 (rank : 93)	NC score	0.277489 (rank : 64)
Query Neighborhood Hits	217	Target Neighborhood Hits	170	Shared Neighborhood Hits	112
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

SYT5_HUMAN
θ value	0.00298849 (rank : 94)	NC score	0.366748 (rank : 32)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	108
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT5_MOUSE
θ value	0.00298849 (rank : 95)	NC score	0.362660 (rank : 35)
Query Neighborhood Hits	217	Target Neighborhood Hits	140	Shared Neighborhood Hits	108
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

VAV2_MOUSE
θ value	0.00298849 (rank : 96)	NC score	0.176993 (rank : 146)
Query Neighborhood Hits	217	Target Neighborhood Hits	456	Shared Neighborhood Hits	60
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
θ value	0.00298849 (rank : 97)	NC score	0.174055 (rank : 151)
Query Neighborhood Hits	217	Target Neighborhood Hits	430	Shared Neighborhood Hits	68
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CPNE8_HUMAN
θ value	0.00390308 (rank : 98)	NC score	0.241271 (rank : 95)
Query Neighborhood Hits	217	Target Neighborhood Hits	86	Shared Neighborhood Hits	73
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

DGKD_HUMAN
θ value	0.00390308 (rank : 99)	NC score	0.252335 (rank : 82)
Query Neighborhood Hits	217	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

MYOF_HUMAN
θ value	0.00390308 (rank : 100)	NC score	0.289886 (rank : 61)
Query Neighborhood Hits	217	Target Neighborhood Hits	147	Shared Neighborhood Hits	104
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

SYT3_HUMAN
θ value	0.00390308 (rank : 101)	NC score	0.371504 (rank : 28)
Query Neighborhood Hits	217	Target Neighborhood Hits	145	Shared Neighborhood Hits	105
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	0.00390308 (rank : 102)	NC score	0.370908 (rank : 31)
Query Neighborhood Hits	217	Target Neighborhood Hits	147	Shared Neighborhood Hits	105
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

VAV3_HUMAN
θ value	0.00390308 (rank : 103)	NC score	0.174903 (rank : 150)
Query Neighborhood Hits	217	Target Neighborhood Hits	398	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ITSN2_HUMAN
θ value	0.00509761 (rank : 104)	NC score	0.171916 (rank : 152)
Query Neighborhood Hits	217	Target Neighborhood Hits	1173	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

RASA3_MOUSE
θ value	0.00509761 (rank : 105)	NC score	0.237733 (rank : 98)
Query Neighborhood Hits	217	Target Neighborhood Hits	144	Shared Neighborhood Hits	69
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

STAC_MOUSE
θ value	0.00509761 (rank : 106)	NC score	0.255303 (rank : 79)
Query Neighborhood Hits	217	Target Neighborhood Hits	268	Shared Neighborhood Hits	71
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CTRO_HUMAN
θ value	0.00665767 (rank : 107)	NC score	0.113186 (rank : 194)
Query Neighborhood Hits	217	Target Neighborhood Hits	2092	Shared Neighborhood Hits	67
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	0.00665767 (rank : 108)	NC score	0.108896 (rank : 219)
Query Neighborhood Hits	217	Target Neighborhood Hits	2344	Shared Neighborhood Hits	71
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

SYT2_MOUSE
θ value	0.00665767 (rank : 109)	NC score	0.362894 (rank : 34)
Query Neighborhood Hits	217	Target Neighborhood Hits	143	Shared Neighborhood Hits	108
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

ARHG2_HUMAN
θ value	0.00869519 (rank : 110)	NC score	0.131411 (rank : 178)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	42
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

CPNE8_MOUSE
θ value	0.00869519 (rank : 111)	NC score	0.235370 (rank : 103)
Query Neighborhood Hits	217	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

STAC_HUMAN
θ value	0.00869519 (rank : 112)	NC score	0.246599 (rank : 90)
Query Neighborhood Hits	217	Target Neighborhood Hits	276	Shared Neighborhood Hits	70
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SYT2_HUMAN
θ value	0.00869519 (rank : 113)	NC score	0.361545 (rank : 36)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	108
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

DYSF_MOUSE
θ value	0.0113563 (rank : 114)	NC score	0.273112 (rank : 68)
Query Neighborhood Hits	217	Target Neighborhood Hits	162	Shared Neighborhood Hits	106
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

BRAF1_HUMAN
θ value	0.0148317 (rank : 115)	NC score	0.089204 (rank : 301)
Query Neighborhood Hits	217	Target Neighborhood Hits	883	Shared Neighborhood Hits	68
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

DGKG_HUMAN
θ value	0.0148317 (rank : 116)	NC score	0.219940 (rank : 116)
Query Neighborhood Hits	217	Target Neighborhood Hits	171	Shared Neighborhood Hits	65
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

DGKH_HUMAN
θ value	0.0148317 (rank : 117)	NC score	0.247186 (rank : 88)
Query Neighborhood Hits	217	Target Neighborhood Hits	255	Shared Neighborhood Hits	74
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

ITSN2_MOUSE
θ value	0.0148317 (rank : 118)	NC score	0.158999 (rank : 161)
Query Neighborhood Hits	217	Target Neighborhood Hits	1371	Shared Neighborhood Hits	120
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

RASA2_HUMAN
θ value	0.0148317 (rank : 119)	NC score	0.252035 (rank : 84)
Query Neighborhood Hits	217	Target Neighborhood Hits	157	Shared Neighborhood Hits	77
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CPNE5_HUMAN
θ value	0.0193708 (rank : 120)	NC score	0.233775 (rank : 106)
Query Neighborhood Hits	217	Target Neighborhood Hits	88	Shared Neighborhood Hits	75
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	0.0193708 (rank : 121)	NC score	0.233948 (rank : 105)
Query Neighborhood Hits	217	Target Neighborhood Hits	86	Shared Neighborhood Hits	75
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

DGKB_HUMAN
θ value	0.0193708 (rank : 122)	NC score	0.220189 (rank : 115)
Query Neighborhood Hits	217	Target Neighborhood Hits	238	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKG_MOUSE
θ value	0.0193708 (rank : 123)	NC score	0.216848 (rank : 117)
Query Neighborhood Hits	217	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

RASA2_MOUSE
θ value	0.0193708 (rank : 124)	NC score	0.253104 (rank : 81)
Query Neighborhood Hits	217	Target Neighborhood Hits	159	Shared Neighborhood Hits	80
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CPNE3_HUMAN
θ value	0.0252991 (rank : 125)	NC score	0.237119 (rank : 99)
Query Neighborhood Hits	217	Target Neighborhood Hits	90	Shared Neighborhood Hits	78
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

PERF_HUMAN
θ value	0.0252991 (rank : 126)	NC score	0.147600 (rank : 165)
Query Neighborhood Hits	217	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

RASF5_HUMAN
θ value	0.0252991 (rank : 127)	NC score	0.196226 (rank : 122)
Query Neighborhood Hits	217	Target Neighborhood Hits	79	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWW0, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99	Gene names	RASSF5, NORE1, RAPL
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

SYT15_HUMAN
θ value	0.0252991 (rank : 128)	NC score	0.286146 (rank : 62)
Query Neighborhood Hits	217	Target Neighborhood Hits	112	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

ARHG2_MOUSE
θ value	0.0330416 (rank : 129)	NC score	0.116070 (rank : 186)
Query Neighborhood Hits	217	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

CPNE3_MOUSE
θ value	0.0330416 (rank : 130)	NC score	0.236887 (rank : 100)
Query Neighborhood Hits	217	Target Neighborhood Hits	90	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

MYO9B_MOUSE
θ value	0.0330416 (rank : 131)	NC score	0.093082 (rank : 289)
Query Neighborhood Hits	217	Target Neighborhood Hits	311	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

PA24A_HUMAN
θ value	0.0330416 (rank : 132)	NC score	0.228731 (rank : 107)
Query Neighborhood Hits	217	Target Neighborhood Hits	88	Shared Neighborhood Hits	74
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24A_MOUSE
θ value	0.0330416 (rank : 133)	NC score	0.234030 (rank : 104)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

MYO9B_HUMAN
θ value	0.0431538 (rank : 134)	NC score	0.093875 (rank : 287)
Query Neighborhood Hits	217	Target Neighborhood Hits	641	Shared Neighborhood Hits	70
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

PERF_MOUSE
θ value	0.0431538 (rank : 135)	NC score	0.139070 (rank : 175)
Query Neighborhood Hits	217	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

SYTL2_MOUSE
θ value	0.0431538 (rank : 136)	NC score	0.291974 (rank : 59)
Query Neighborhood Hits	217	Target Neighborhood Hits	253	Shared Neighborhood Hits	94
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

CAPS1_HUMAN
θ value	0.0563607 (rank : 137)	NC score	0.127747 (rank : 180)
Query Neighborhood Hits	217	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULU8, Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2	Gene names	CADPS, CAPS, CAPS1, KIAA1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

CAPS1_MOUSE
θ value	0.0563607 (rank : 138)	NC score	0.128551 (rank : 179)
Query Neighborhood Hits	217	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q80TJ1, Q3TSP2, Q61374, Q6AXB4, Q6PGF0	Gene names	Cadps, Caps, Caps1, Kiaa1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

PA24E_HUMAN
θ value	0.0563607 (rank : 139)	NC score	0.235520 (rank : 102)
Query Neighborhood Hits	217	Target Neighborhood Hits	89	Shared Neighborhood Hits	76
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

ABR_HUMAN
θ value	0.0736092 (rank : 140)	NC score	0.099451 (rank : 264)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	31
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

PA24E_MOUSE
θ value	0.0736092 (rank : 141)	NC score	0.242250 (rank : 94)
Query Neighborhood Hits	217	Target Neighborhood Hits	95	Shared Neighborhood Hits	77
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PDZD8_HUMAN
θ value	0.0961366 (rank : 142)	NC score	0.277327 (rank : 65)
Query Neighborhood Hits	217	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SYT15_MOUSE
θ value	0.0961366 (rank : 143)	NC score	0.261360 (rank : 78)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	75
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYTL2_HUMAN
θ value	0.0961366 (rank : 144)	NC score	0.291828 (rank : 60)
Query Neighborhood Hits	217	Target Neighborhood Hits	248	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

ITSN1_HUMAN
θ value	0.163984 (rank : 145)	NC score	0.131443 (rank : 177)
Query Neighborhood Hits	217	Target Neighborhood Hits	1757	Shared Neighborhood Hits	127
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.163984 (rank : 146)	NC score	0.131546 (rank : 176)
Query Neighborhood Hits	217	Target Neighborhood Hits	1669	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

CPNE4_HUMAN
θ value	0.21417 (rank : 147)	NC score	0.188059 (rank : 126)
Query Neighborhood Hits	217	Target Neighborhood Hits	70	Shared Neighborhood Hits	64
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	0.21417 (rank : 148)	NC score	0.187655 (rank : 127)
Query Neighborhood Hits	217	Target Neighborhood Hits	67	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CPNE1_HUMAN
θ value	0.279714 (rank : 149)	NC score	0.197888 (rank : 120)
Query Neighborhood Hits	217	Target Neighborhood Hits	70	Shared Neighborhood Hits	66
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

P3C2A_HUMAN
θ value	0.279714 (rank : 150)	NC score	0.147602 (rank : 164)
Query Neighborhood Hits	217	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

STAC3_HUMAN
θ value	0.279714 (rank : 151)	NC score	0.223984 (rank : 110)
Query Neighborhood Hits	217	Target Neighborhood Hits	228	Shared Neighborhood Hits	66
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.279714 (rank : 152)	NC score	0.226934 (rank : 108)
Query Neighborhood Hits	217	Target Neighborhood Hits	232	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CPNE1_MOUSE
θ value	0.365318 (rank : 153)	NC score	0.211843 (rank : 118)
Query Neighborhood Hits	217	Target Neighborhood Hits	83	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

RAF1_HUMAN
θ value	0.365318 (rank : 154)	NC score	0.086513 (rank : 305)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	66
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	0.365318 (rank : 155)	NC score	0.087188 (rank : 303)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	66
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

CPNE6_MOUSE
θ value	0.47712 (rank : 156)	NC score	0.184970 (rank : 128)
Query Neighborhood Hits	217	Target Neighborhood Hits	87	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

GMIP_MOUSE
θ value	0.47712 (rank : 157)	NC score	0.115324 (rank : 187)
Query Neighborhood Hits	217	Target Neighborhood Hits	202	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

CPNE6_HUMAN
θ value	0.62314 (rank : 158)	NC score	0.184104 (rank : 131)
Query Neighborhood Hits	217	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

ARAF_HUMAN
θ value	0.813845 (rank : 159)	NC score	0.083032 (rank : 334)
Query Neighborhood Hits	217	Target Neighborhood Hits	924	Shared Neighborhood Hits	66
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	0.813845 (rank : 160)	NC score	0.083819 (rank : 322)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	63
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

CPNE7_HUMAN
θ value	0.813845 (rank : 161)	NC score	0.196512 (rank : 121)
Query Neighborhood Hits	217	Target Neighborhood Hits	92	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

DOC2G_MOUSE
θ value	0.813845 (rank : 162)	NC score	0.347769 (rank : 37)
Query Neighborhood Hits	217	Target Neighborhood Hits	125	Shared Neighborhood Hits	92
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

GMIP_HUMAN
θ value	0.813845 (rank : 163)	NC score	0.111207 (rank : 207)
Query Neighborhood Hits	217	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

OTOF_HUMAN
θ value	0.813845 (rank : 164)	NC score	0.263855 (rank : 74)
Query Neighborhood Hits	217	Target Neighborhood Hits	168	Shared Neighborhood Hits	100
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
θ value	0.813845 (rank : 165)	NC score	0.262922 (rank : 76)
Query Neighborhood Hits	217	Target Neighborhood Hits	196	Shared Neighborhood Hits	99
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

P3C2A_MOUSE
θ value	0.813845 (rank : 166)	NC score	0.143872 (rank : 172)
Query Neighborhood Hits	217	Target Neighborhood Hits	181	Shared Neighborhood Hits	61
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

SYT11_HUMAN
θ value	0.813845 (rank : 167)	NC score	0.308697 (rank : 51)
Query Neighborhood Hits	217	Target Neighborhood Hits	113	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	0.813845 (rank : 168)	NC score	0.310319 (rank : 48)
Query Neighborhood Hits	217	Target Neighborhood Hits	116	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

DGKA_HUMAN
θ value	1.06291 (rank : 169)	NC score	0.162859 (rank : 157)
Query Neighborhood Hits	217	Target Neighborhood Hits	151	Shared Neighborhood Hits	57
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

CLSPN_HUMAN
θ value	1.38821 (rank : 170)	NC score	0.024226 (rank : 871)
Query Neighborhood Hits	217	Target Neighborhood Hits	433	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

SYT4_MOUSE
θ value	1.38821 (rank : 171)	NC score	0.316241 (rank : 45)
Query Neighborhood Hits	217	Target Neighborhood Hits	123	Shared Neighborhood Hits	93
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

BCR_HUMAN
θ value	1.81305 (rank : 172)	NC score	0.084827 (rank : 311)
Query Neighborhood Hits	217	Target Neighborhood Hits	204	Shared Neighborhood Hits	34
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CAN6_MOUSE
θ value	1.81305 (rank : 173)	NC score	0.029082 (rank : 866)
Query Neighborhood Hits	217	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	O35646	Gene names	Capn6, Capa6
Domain Architecture
Description	Calpain-6.

KSR2_HUMAN
θ value	1.81305 (rank : 174)	NC score	0.069720 (rank : 527)
Query Neighborhood Hits	217	Target Neighborhood Hits	920	Shared Neighborhood Hits	61
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

PA24F_HUMAN
θ value	1.81305 (rank : 175)	NC score	0.183429 (rank : 134)
Query Neighborhood Hits	217	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

SYT4_HUMAN
θ value	1.81305 (rank : 176)	NC score	0.310213 (rank : 49)
Query Neighborhood Hits	217	Target Neighborhood Hits	121	Shared Neighborhood Hits	92
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYTL1_HUMAN
θ value	1.81305 (rank : 177)	NC score	0.270647 (rank : 69)
Query Neighborhood Hits	217	Target Neighborhood Hits	227	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

CCNT1_MOUSE
θ value	2.36792 (rank : 178)	NC score	0.012286 (rank : 880)
Query Neighborhood Hits	217	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QWV9, Q9Z0U7	Gene names	Ccnt1
Domain Architecture
Description	Cyclin-T1 (CycT1) (Cyclin-T).

BAZ1B_HUMAN
θ value	3.0926 (rank : 179)	NC score	0.014458 (rank : 877)
Query Neighborhood Hits	217	Target Neighborhood Hits	701	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

IWS1_MOUSE
θ value	3.0926 (rank : 180)	NC score	0.030136 (rank : 865)
Query Neighborhood Hits	217	Target Neighborhood Hits	1258	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K0528_HUMAN
θ value	3.0926 (rank : 181)	NC score	0.222677 (rank : 113)
Query Neighborhood Hits	217	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	3.0926 (rank : 182)	NC score	0.222700 (rank : 112)
Query Neighborhood Hits	217	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

MYT1L_HUMAN
θ value	3.0926 (rank : 183)	NC score	0.013116 (rank : 879)
Query Neighborhood Hits	217	Target Neighborhood Hits	471	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UL68, Q6IQ17, Q9UPP6	Gene names	MYT1L, KIAA1106
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L).

ZNFX1_HUMAN
θ value	3.0926 (rank : 184)	NC score	0.006945 (rank : 887)
Query Neighborhood Hits	217	Target Neighborhood Hits	308	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

CMGA_HUMAN
θ value	4.03905 (rank : 185)	NC score	0.018034 (rank : 873)
Query Neighborhood Hits	217	Target Neighborhood Hits	238	Shared Neighborhood Hits	9
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

COR2B_HUMAN
θ value	4.03905 (rank : 186)	NC score	0.002778 (rank : 893)
Query Neighborhood Hits	217	Target Neighborhood Hits	233	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UQ03, O94767, Q8TAN1	Gene names	CORO2B, KIAA0925
Domain Architecture
Description	Coronin-2B (Coronin-like protein C) (ClipinC) (Protein FC96).

DOCK4_MOUSE
θ value	4.03905 (rank : 187)	NC score	0.009346 (rank : 885)
Query Neighborhood Hits	217	Target Neighborhood Hits	210	Shared Neighborhood Hits	10
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

HUTU_HUMAN
θ value	4.03905 (rank : 188)	NC score	0.024558 (rank : 869)
Query Neighborhood Hits	217	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q96N76	Gene names	UROC1
Domain Architecture
Description	Probable urocanate hydratase (EC 4.2.1.49) (Urocanase) (Imidazolonepropionate hydrolase).

MOES_HUMAN
θ value	4.03905 (rank : 189)	NC score	0.017629 (rank : 874)
Query Neighborhood Hits	217	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

RNF13_MOUSE
θ value	4.03905 (rank : 190)	NC score	0.006535 (rank : 888)
Query Neighborhood Hits	217	Target Neighborhood Hits	164	Shared Neighborhood Hits	2
SwissProt Accessions	O54965, O54966	Gene names	Rnf13, Rzf
Domain Architecture
Description	RING finger protein 13.

BAI2_HUMAN
θ value	5.27518 (rank : 191)	NC score	0.010257 (rank : 882)
Query Neighborhood Hits	217	Target Neighborhood Hits	332	Shared Neighborhood Hits	9
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
θ value	5.27518 (rank : 192)	NC score	0.009673 (rank : 883)
Query Neighborhood Hits	217	Target Neighborhood Hits	323	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI3_HUMAN
θ value	5.27518 (rank : 193)	NC score	0.009532 (rank : 884)
Query Neighborhood Hits	217	Target Neighborhood Hits	246	Shared Neighborhood Hits	7
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

DGKK_HUMAN
θ value	5.27518 (rank : 194)	NC score	0.109900 (rank : 215)
Query Neighborhood Hits	217	Target Neighborhood Hits	378	Shared Neighborhood Hits	42
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

FBXL5_MOUSE
θ value	5.27518 (rank : 195)	NC score	0.011049 (rank : 881)
Query Neighborhood Hits	217	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C2S5, Q3TWC9, Q80XI5, Q8BGF5, Q8BNL3, Q8C3Q8	Gene names	Fbxl5
Domain Architecture
Description	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5).

NIN_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.016473 (rank : 876)
Query Neighborhood Hits	217	Target Neighborhood Hits	1416	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

ROCK2_HUMAN
θ value	5.27518 (rank : 197)	NC score	0.102592 (rank : 250)
Query Neighborhood Hits	217	Target Neighborhood Hits	2073	Shared Neighborhood Hits	63
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ROCK2_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.102718 (rank : 249)
Query Neighborhood Hits	217	Target Neighborhood Hits	2072	Shared Neighborhood Hits	65
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SYTL5_MOUSE
θ value	5.27518 (rank : 199)	NC score	0.251722 (rank : 85)
Query Neighborhood Hits	217	Target Neighborhood Hits	154	Shared Neighborhood Hits	96
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

WDR12_HUMAN
θ value	5.27518 (rank : 200)	NC score	0.005830 (rank : 891)
Query Neighborhood Hits	217	Target Neighborhood Hits	300	Shared Neighborhood Hits	5
SwissProt Accessions	Q9GZL7, Q96HU0, Q9NV80, Q9NYI8	Gene names	WDR12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

ANR12_HUMAN
θ value	6.88961 (rank : 201)	NC score	0.006343 (rank : 889)
Query Neighborhood Hits	217	Target Neighborhood Hits	1081	Shared Neighborhood Hits	22
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

CAN6_HUMAN
θ value	6.88961 (rank : 202)	NC score	0.021001 (rank : 872)
Query Neighborhood Hits	217	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6Q1, Q9UEQ1, Q9UJA8	Gene names	CAPN6, CALPM, CANPX
Domain Architecture
Description	Calpain-6 (Calpamodulin) (CalpM) (Calpain-like protease X-linked).

GLU2B_HUMAN
θ value	6.88961 (rank : 203)	NC score	0.026040 (rank : 868)
Query Neighborhood Hits	217	Target Neighborhood Hits	377	Shared Neighborhood Hits	17
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

ITCH_HUMAN
θ value	6.88961 (rank : 204)	NC score	0.092180 (rank : 292)
Query Neighborhood Hits	217	Target Neighborhood Hits	162	Shared Neighborhood Hits	31
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

MOES_MOUSE
θ value	6.88961 (rank : 205)	NC score	0.013548 (rank : 878)
Query Neighborhood Hits	217	Target Neighborhood Hits	923	Shared Neighborhood Hits	26
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

NFM_HUMAN
θ value	6.88961 (rank : 206)	NC score	0.009337 (rank : 886)
Query Neighborhood Hits	217	Target Neighborhood Hits	1328	Shared Neighborhood Hits	35
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

PININ_HUMAN
θ value	6.88961 (rank : 207)	NC score	0.027980 (rank : 867)
Query Neighborhood Hits	217	Target Neighborhood Hits	753	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

RGAP1_HUMAN
θ value	6.88961 (rank : 208)	NC score	0.091500 (rank : 295)
Query Neighborhood Hits	217	Target Neighborhood Hits	189	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RPTN_MOUSE
θ value	6.88961 (rank : 209)	NC score	0.003401 (rank : 892)
Query Neighborhood Hits	217	Target Neighborhood Hits	650	Shared Neighborhood Hits	14
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

CROCC_HUMAN
θ value	8.99809 (rank : 210)	NC score	0.016914 (rank : 875)
Query Neighborhood Hits	217	Target Neighborhood Hits	1409	Shared Neighborhood Hits	38
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

FER_HUMAN
θ value	8.99809 (rank : 211)	NC score	0.057621 (rank : 742)
Query Neighborhood Hits	217	Target Neighborhood Hits	1278	Shared Neighborhood Hits	58
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

HHLA2_HUMAN
θ value	8.99809 (rank : 212)	NC score	0.006282 (rank : 890)
Query Neighborhood Hits	217	Target Neighborhood Hits	140	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

ITCH_MOUSE
θ value	8.99809 (rank : 213)	NC score	0.089694 (rank : 299)
Query Neighborhood Hits	217	Target Neighborhood Hits	127	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

KCNV2_HUMAN
θ value	8.99809 (rank : 214)	NC score	0.000379 (rank : 894)
Query Neighborhood Hits	217	Target Neighborhood Hits	137	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

P3C2B_HUMAN
θ value	8.99809 (rank : 215)	NC score	0.166558 (rank : 154)
Query Neighborhood Hits	217	Target Neighborhood Hits	148	Shared Neighborhood Hits	66
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PININ_MOUSE
θ value	8.99809 (rank : 216)	NC score	0.024402 (rank : 870)
Query Neighborhood Hits	217	Target Neighborhood Hits	777	Shared Neighborhood Hits	31
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

RGNEF_MOUSE
θ value	8.99809 (rank : 217)	NC score	0.104074 (rank : 244)
Query Neighborhood Hits	217	Target Neighborhood Hits	641	Shared Neighborhood Hits	76
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

3BP1_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.050942 (rank : 852)
Query Neighborhood Hits	217	Target Neighborhood Hits	376	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

3BP1_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.051466 (rank : 842)
Query Neighborhood Hits	217	Target Neighborhood Hits	238	Shared Neighborhood Hits	15
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AAK1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.056008 (rank : 772)
Query Neighborhood Hits	217	Target Neighborhood Hits	1077	Shared Neighborhood Hits	46
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.054595 (rank : 798)
Query Neighborhood Hits	217	Target Neighborhood Hits	1051	Shared Neighborhood Hits	42
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAPK1_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.081223 (rank : 367)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.081660 (rank : 362)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.082017 (rank : 356)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.050339 (rank : 858)
Query Neighborhood Hits	217	Target Neighborhood Hits	1243	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.050964 (rank : 851)
Query Neighborhood Hits	217	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.061478 (rank : 677)
Query Neighborhood Hits	217	Target Neighborhood Hits	1220	Shared Neighborhood Hits	64
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.061062 (rank : 682)
Query Neighborhood Hits	217	Target Neighborhood Hits	1178	Shared Neighborhood Hits	65
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.060303 (rank : 694)
Query Neighborhood Hits	217	Target Neighborhood Hits	1045	Shared Neighborhood Hits	57
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

AKT1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.112637 (rank : 196)
Query Neighborhood Hits	217	Target Neighborhood Hits	885	Shared Neighborhood Hits	42
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.112599 (rank : 198)
Query Neighborhood Hits	217	Target Neighborhood Hits	878	Shared Neighborhood Hits	41
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT2_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.110769 (rank : 210)
Query Neighborhood Hits	217	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.110792 (rank : 209)
Query Neighborhood Hits	217	Target Neighborhood Hits	875	Shared Neighborhood Hits	40
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.110724 (rank : 212)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.110758 (rank : 211)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AL2S2_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.051751 (rank : 839)
Query Neighborhood Hits	217	Target Neighborhood Hits	727	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.051275 (rank : 845)
Query Neighborhood Hits	217	Target Neighborhood Hits	709	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.063963 (rank : 641)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	39
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ARBK1_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.108887 (rank : 220)
Query Neighborhood Hits	217	Target Neighborhood Hits	859	Shared Neighborhood Hits	41
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.108561 (rank : 221)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	41
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK2_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.107713 (rank : 224)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

AURKB_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.083569 (rank : 324)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.084509 (rank : 315)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.084449 (rank : 317)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKC_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.084466 (rank : 316)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	39
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

BLK_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.051475 (rank : 841)
Query Neighborhood Hits	217	Target Neighborhood Hits	994	Shared Neighborhood Hits	53
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.050219 (rank : 861)
Query Neighborhood Hits	217	Target Neighborhood Hits	992	Shared Neighborhood Hits	53
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMP2K_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.055394 (rank : 783)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMP2K_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.054841 (rank : 793)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	44
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMX_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.066244 (rank : 592)
Query Neighborhood Hits	217	Target Neighborhood Hits	942	Shared Neighborhood Hits	52
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.065358 (rank : 609)
Query Neighborhood Hits	217	Target Neighborhood Hits	912	Shared Neighborhood Hits	50
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRSK1_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.079556 (rank : 388)
Query Neighborhood Hits	217	Target Neighborhood Hits	942	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.078340 (rank : 411)
Query Neighborhood Hits	217	Target Neighborhood Hits	897	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

BTK_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.066933 (rank : 577)
Query Neighborhood Hits	217	Target Neighborhood Hits	1026	Shared Neighborhood Hits	60
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.066580 (rank : 583)
Query Neighborhood Hits	217	Target Neighborhood Hits	1017	Shared Neighborhood Hits	60
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BUB1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.050330 (rank : 859)
Query Neighborhood Hits	217	Target Neighborhood Hits	583	Shared Neighborhood Hits	36
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CAMKV_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.078368 (rank : 409)
Query Neighborhood Hits	217	Target Neighborhood Hits	1084	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.078181 (rank : 417)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CCRK_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.060105 (rank : 696)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CCRK_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.060522 (rank : 691)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CD2L1_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.060724 (rank : 687)
Query Neighborhood Hits	217	Target Neighborhood Hits	1467	Shared Neighborhood Hits	55
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.061333 (rank : 679)
Query Neighborhood Hits	217	Target Neighborhood Hits	1463	Shared Neighborhood Hits	56
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L2_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.060995 (rank : 683)
Query Neighborhood Hits	217	Target Neighborhood Hits	1439	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CD2L5_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.056103 (rank : 769)
Query Neighborhood Hits	217	Target Neighborhood Hits	987	Shared Neighborhood Hits	41
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.056057 (rank : 771)
Query Neighborhood Hits	217	Target Neighborhood Hits	1011	Shared Neighborhood Hits	40
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L6_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.050771 (rank : 856)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.051188 (rank : 847)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L7_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.057283 (rank : 746)
Query Neighborhood Hits	217	Target Neighborhood Hits	1275	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDC2_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.061930 (rank : 668)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.062106 (rank : 665)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC7_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.054040 (rank : 806)
Query Neighborhood Hits	217	Target Neighborhood Hits	652	Shared Neighborhood Hits	35
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CDC7_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.063475 (rank : 645)
Query Neighborhood Hits	217	Target Neighborhood Hits	641	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CDK10_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.057019 (rank : 752)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	39
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CDK2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.062497 (rank : 656)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.060823 (rank : 685)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.058428 (rank : 724)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK3_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.063308 (rank : 647)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK4_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.054796 (rank : 794)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.054372 (rank : 804)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK5_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.060541 (rank : 689)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	39
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.060539 (rank : 690)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	39
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK6_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.057150 (rank : 748)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.057752 (rank : 739)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDK7_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.058868 (rank : 716)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.058980 (rank : 712)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDKL1_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.059418 (rank : 705)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL1_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.060208 (rank : 695)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL2_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.063878 (rank : 642)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.064690 (rank : 629)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL3_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.061888 (rank : 669)
Query Neighborhood Hits	217	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.061858 (rank : 670)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL4_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.060856 (rank : 684)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.061556 (rank : 674)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.070384 (rank : 517)
Query Neighborhood Hits	217	Target Neighborhood Hits	967	Shared Neighborhood Hits	42
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CHK1_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.072655 (rank : 487)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.072012 (rank : 493)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK2_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.079534 (rank : 389)
Query Neighborhood Hits	217	Target Neighborhood Hits	859	Shared Neighborhood Hits	39
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

CHK2_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.079572 (rank : 387)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

CLK1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.050160 (rank : 862)
Query Neighborhood Hits	217	Target Neighborhood Hits	756	Shared Neighborhood Hits	40
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CSK21_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.063503 (rank : 644)
Query Neighborhood Hits	217	Target Neighborhood Hits	772	Shared Neighborhood Hits	38
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.064497 (rank : 636)
Query Neighborhood Hits	217	Target Neighborhood Hits	770	Shared Neighborhood Hits	38
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK22_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.065110 (rank : 615)
Query Neighborhood Hits	217	Target Neighborhood Hits	758	Shared Neighborhood Hits	38
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.064964 (rank : 617)
Query Neighborhood Hits	217	Target Neighborhood Hits	758	Shared Neighborhood Hits	38
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSKP_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.074477 (rank : 468)
Query Neighborhood Hits	217	Target Neighborhood Hits	1022	Shared Neighborhood Hits	47
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.075087 (rank : 464)
Query Neighborhood Hits	217	Target Neighborhood Hits	1027	Shared Neighborhood Hits	49
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSK_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.059237 (rank : 709)
Query Neighborhood Hits	217	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.059950 (rank : 697)
Query Neighborhood Hits	217	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAB2P_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.056177 (rank : 767)
Query Neighborhood Hits	217	Target Neighborhood Hits	303	Shared Neighborhood Hits	19
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

DAB2P_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.055089 (rank : 790)
Query Neighborhood Hits	217	Target Neighborhood Hits	284	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DAPK1_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.064789 (rank : 626)
Query Neighborhood Hits	217	Target Neighborhood Hits	1130	Shared Neighborhood Hits	40
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.064763 (rank : 627)
Query Neighborhood Hits	217	Target Neighborhood Hits	1138	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.077220 (rank : 428)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.078253 (rank : 413)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.076730 (rank : 442)
Query Neighborhood Hits	217	Target Neighborhood Hits	945	Shared Neighborhood Hits	45
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.075796 (rank : 456)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DCAK1_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.075849 (rank : 455)
Query Neighborhood Hits	217	Target Neighborhood Hits	877	Shared Neighborhood Hits	39
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.075886 (rank : 454)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.077775 (rank : 421)
Query Neighborhood Hits	217	Target Neighborhood Hits	862	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.077053 (rank : 434)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK3_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.083599 (rank : 323)
Query Neighborhood Hits	217	Target Neighborhood Hits	888	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.083538 (rank : 325)
Query Neighborhood Hits	217	Target Neighborhood Hits	922	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DGKA_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.112218 (rank : 199)
Query Neighborhood Hits	217	Target Neighborhood Hits	146	Shared Neighborhood Hits	46
SwissProt Accessions	O88673, Q922X2	Gene names	Dgka, Dagk1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

DGKE_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.068875 (rank : 540)
Query Neighborhood Hits	217	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	P52429, Q9UKQ3	Gene names	DGKE, DAGK5
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

DGKE_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.065202 (rank : 614)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R1C6	Gene names	Dgke
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

DMPK_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.117975 (rank : 184)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	40
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.118349 (rank : 183)
Query Neighborhood Hits	217	Target Neighborhood Hits	908	Shared Neighborhood Hits	41
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DUET_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.080960 (rank : 371)
Query Neighborhood Hits	217	Target Neighborhood Hits	1220	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DYR1A_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.073533 (rank : 476)
Query Neighborhood Hits	217	Target Neighborhood Hits	764	Shared Neighborhood Hits	39
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.073522 (rank : 477)
Query Neighborhood Hits	217	Target Neighborhood Hits	762	Shared Neighborhood Hits	39
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1B_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.072873 (rank : 483)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

DYR1B_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.071424 (rank : 502)
Query Neighborhood Hits	217	Target Neighborhood Hits	799	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYRK2_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.069264 (rank : 535)
Query Neighborhood Hits	217	Target Neighborhood Hits	799	Shared Neighborhood Hits	39
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

DYRK3_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.065887 (rank : 599)
Query Neighborhood Hits	217	Target Neighborhood Hits	798	Shared Neighborhood Hits	40
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

DYRK4_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.060332 (rank : 692)
Query Neighborhood Hits	217	Target Neighborhood Hits	750	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

E2AK1_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.058689 (rank : 721)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.062715 (rank : 653)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.067545 (rank : 567)
Query Neighborhood Hits	217	Target Neighborhood Hits	856	Shared Neighborhood Hits	39
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.073161 (rank : 480)
Query Neighborhood Hits	217	Target Neighborhood Hits	864	Shared Neighborhood Hits	39
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK3_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.056820 (rank : 757)
Query Neighborhood Hits	217	Target Neighborhood Hits	859	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.058189 (rank : 725)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

E2AK4_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.066545 (rank : 584)
Query Neighborhood Hits	217	Target Neighborhood Hits	1012	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

E2AK4_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.068224 (rank : 548)
Query Neighborhood Hits	217	Target Neighborhood Hits	984	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

EDD1_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.052914 (rank : 821)
Query Neighborhood Hits	217	Target Neighborhood Hits	170	Shared Neighborhood Hits	12
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.052831 (rank : 822)
Query Neighborhood Hits	217	Target Neighborhood Hits	167	Shared Neighborhood Hits	11
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

ERN1_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.056878 (rank : 756)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	41
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN1_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.057976 (rank : 731)
Query Neighborhood Hits	217	Target Neighborhood Hits	823	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.058828 (rank : 717)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	38
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.064340 (rank : 637)
Query Neighborhood Hits	217	Target Neighborhood Hits	825	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

F5006_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.095121 (rank : 284)
Query Neighborhood Hits	217	Target Neighborhood Hits	794	Shared Neighborhood Hits	39
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

F5006_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.094843 (rank : 286)
Query Neighborhood Hits	217	Target Neighborhood Hits	793	Shared Neighborhood Hits	39
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

FES_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.053043 (rank : 817)
Query Neighborhood Hits	217	Target Neighborhood Hits	978	Shared Neighborhood Hits	42
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.051693 (rank : 840)
Query Neighborhood Hits	217	Target Neighborhood Hits	980	Shared Neighborhood Hits	41
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.052725 (rank : 825)
Query Neighborhood Hits	217	Target Neighborhood Hits	1067	Shared Neighborhood Hits	56
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.050921 (rank : 853)
Query Neighborhood Hits	217	Target Neighborhood Hits	1069	Shared Neighborhood Hits	56
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FNBP2_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.052009 (rank : 836)
Query Neighborhood Hits	217	Target Neighborhood Hits	432	Shared Neighborhood Hits	35
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FRK_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.055995 (rank : 773)
Query Neighborhood Hits	217	Target Neighborhood Hits	1058	Shared Neighborhood Hits	56
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.057105 (rank : 750)
Query Neighborhood Hits	217	Target Neighborhood Hits	1078	Shared Neighborhood Hits	56
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.055693 (rank : 775)
Query Neighborhood Hits	217	Target Neighborhood Hits	1073	Shared Neighborhood Hits	56
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GAK_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.051834 (rank : 837)
Query Neighborhood Hits	217	Target Neighborhood Hits	1028	Shared Neighborhood Hits	42
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAK_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.053792 (rank : 809)
Query Neighborhood Hits	217	Target Neighborhood Hits	964	Shared Neighborhood Hits	42
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GRK4_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.107919 (rank : 223)
Query Neighborhood Hits	217	Target Neighborhood Hits	822	Shared Neighborhood Hits	38
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.108273 (rank : 222)
Query Neighborhood Hits	217	Target Neighborhood Hits	808	Shared Neighborhood Hits	38
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.106334 (rank : 228)
Query Neighborhood Hits	217	Target Neighborhood Hits	819	Shared Neighborhood Hits	39
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.106231 (rank : 229)
Query Neighborhood Hits	217	Target Neighborhood Hits	823	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.104123 (rank : 242)
Query Neighborhood Hits	217	Target Neighborhood Hits	823	Shared Neighborhood Hits	39
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.104973 (rank : 237)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	39
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK7_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.107015 (rank : 226)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

GSK3A_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.066011 (rank : 594)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

GSK3B_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.065278 (rank : 612)
Query Neighborhood Hits	217	Target Neighborhood Hits	801	Shared Neighborhood Hits	39
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.065278 (rank : 613)
Query Neighborhood Hits	217	Target Neighborhood Hits	800	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

HCK_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.055153 (rank : 788)
Query Neighborhood Hits	217	Target Neighborhood Hits	1035	Shared Neighborhood Hits	55
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.053837 (rank : 807)
Query Neighborhood Hits	217	Target Neighborhood Hits	1029	Shared Neighborhood Hits	53
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HECD2_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.070064 (rank : 523)
Query Neighborhood Hits	217	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.070587 (rank : 511)
Query Neighborhood Hits	217	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC3_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.057896 (rank : 733)
Query Neighborhood Hits	217	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.061506 (rank : 676)
Query Neighborhood Hits	217	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HIPK1_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.066424 (rank : 588)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.066428 (rank : 587)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HIPK2_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.067893 (rank : 560)
Query Neighborhood Hits	217	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.067868 (rank : 561)
Query Neighborhood Hits	217	Target Neighborhood Hits	871	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

HIPK3_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.065750 (rank : 603)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.066247 (rank : 591)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK4_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.065890 (rank : 598)
Query Neighborhood Hits	217	Target Neighborhood Hits	799	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

HUNK_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.083081 (rank : 333)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	39
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.082842 (rank : 338)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

HUWE1_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.074487 (rank : 467)
Query Neighborhood Hits	217	Target Neighborhood Hits	443	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.074652 (rank : 465)
Query Neighborhood Hits	217	Target Neighborhood Hits	406	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ICK_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.058160 (rank : 727)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.058629 (rank : 722)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

IKKA_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.073084 (rank : 481)
Query Neighborhood Hits	217	Target Neighborhood Hits	863	Shared Neighborhood Hits	39
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.072923 (rank : 482)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.072123 (rank : 492)
Query Neighborhood Hits	217	Target Neighborhood Hits	980	Shared Neighborhood Hits	39
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.072298 (rank : 489)
Query Neighborhood Hits	217	Target Neighborhood Hits	984	Shared Neighborhood Hits	41
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.068022 (rank : 555)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.064558 (rank : 633)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IRAK1_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.059807 (rank : 699)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	39
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.065024 (rank : 616)
Query Neighborhood Hits	217	Target Neighborhood Hits	784	Shared Neighborhood Hits	39
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK4_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.057775 (rank : 738)
Query Neighborhood Hits	217	Target Neighborhood Hits	816	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.061715 (rank : 672)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITK_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.057048 (rank : 751)
Query Neighborhood Hits	217	Target Neighborhood Hits	1016	Shared Neighborhood Hits	58
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 401)	NC score	0.057010 (rank : 753)
Query Neighborhood Hits	217	Target Neighborhood Hits	985	Shared Neighborhood Hits	57
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK3_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.053784 (rank : 810)
Query Neighborhood Hits	217	Target Neighborhood Hits	827	Shared Neighborhood Hits	39
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.054591 (rank : 799)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

K0317_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.077091 (rank : 433)
Query Neighborhood Hits	217	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.077201 (rank : 429)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0999_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.077877 (rank : 419)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.077862 (rank : 420)
Query Neighborhood Hits	217	Target Neighborhood Hits	931	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KAPCA_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.104242 (rank : 241)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.104478 (rank : 239)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.104952 (rank : 238)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.105141 (rank : 235)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCG_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.101222 (rank : 253)
Query Neighborhood Hits	217	Target Neighborhood Hits	845	Shared Neighborhood Hits	39
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KC1AL_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.056322 (rank : 765)
Query Neighborhood Hits	217	Target Neighborhood Hits	734	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KC1G1_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.054608 (rank : 797)
Query Neighborhood Hits	217	Target Neighborhood Hits	708	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.054199 (rank : 805)
Query Neighborhood Hits	217	Target Neighborhood Hits	713	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G2_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.051025 (rank : 850)
Query Neighborhood Hits	217	Target Neighborhood Hits	693	Shared Neighborhood Hits	39
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.053048 (rank : 816)
Query Neighborhood Hits	217	Target Neighborhood Hits	695	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G3_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.052804 (rank : 823)
Query Neighborhood Hits	217	Target Neighborhood Hits	711	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KCC1A_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.082747 (rank : 340)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.082471 (rank : 349)
Query Neighborhood Hits	217	Target Neighborhood Hits	845	Shared Neighborhood Hits	39
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1B_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.083222 (rank : 330)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.083180 (rank : 331)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.084657 (rank : 313)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.084650 (rank : 314)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.082730 (rank : 341)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	39
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.082955 (rank : 335)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2A_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.076532 (rank : 444)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.076707 (rank : 443)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.076504 (rank : 445)
Query Neighborhood Hits	217	Target Neighborhood Hits	866	Shared Neighborhood Hits	40
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.075982 (rank : 450)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2D_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.076983 (rank : 436)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KCC2G_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.076972 (rank : 438)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.076972 (rank : 437)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC4_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.082631 (rank : 345)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.082887 (rank : 336)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KGP1A_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.100747 (rank : 257)
Query Neighborhood Hits	217	Target Neighborhood Hits	901	Shared Neighborhood Hits	39
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.100653 (rank : 260)
Query Neighborhood Hits	217	Target Neighborhood Hits	921	Shared Neighborhood Hits	39
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.100667 (rank : 259)
Query Neighborhood Hits	217	Target Neighborhood Hits	922	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP2_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.097702 (rank : 270)
Query Neighborhood Hits	217	Target Neighborhood Hits	1023	Shared Neighborhood Hits	44
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.097987 (rank : 269)
Query Neighborhood Hits	217	Target Neighborhood Hits	1029	Shared Neighborhood Hits	43
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KKCC1_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.081107 (rank : 370)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.082013 (rank : 357)
Query Neighborhood Hits	217	Target Neighborhood Hits	866	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.078967 (rank : 401)
Query Neighborhood Hits	217	Target Neighborhood Hits	852	Shared Neighborhood Hits	39
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.078987 (rank : 398)
Query Neighborhood Hits	217	Target Neighborhood Hits	855	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPSH1_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.081294 (rank : 365)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.081194 (rank : 368)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.083532 (rank : 326)
Query Neighborhood Hits	217	Target Neighborhood Hits	822	Shared Neighborhood Hits	39
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A1_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.096330 (rank : 276)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	39
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.096559 (rank : 275)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	39
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.095604 (rank : 281)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.095206 (rank : 283)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.096051 (rank : 278)
Query Neighborhood Hits	217	Target Neighborhood Hits	859	Shared Neighborhood Hits	39
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.096054 (rank : 277)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A4_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.105194 (rank : 234)
Query Neighborhood Hits	217	Target Neighborhood Hits	868	Shared Neighborhood Hits	39
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A4_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.105046 (rank : 236)
Query Neighborhood Hits	217	Target Neighborhood Hits	866	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

KS6A5_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.103017 (rank : 247)
Query Neighborhood Hits	217	Target Neighborhood Hits	855	Shared Neighborhood Hits	39
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6A5_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.106883 (rank : 227)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

KS6A6_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.096613 (rank : 274)
Query Neighborhood Hits	217	Target Neighborhood Hits	853	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6B1_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.105473 (rank : 232)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	39
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.105483 (rank : 231)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B2_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.105364 (rank : 233)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KS6B2_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.106121 (rank : 230)
Query Neighborhood Hits	217	Target Neighborhood Hits	871	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KS6C1_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.114681 (rank : 188)
Query Neighborhood Hits	217	Target Neighborhood Hits	682	Shared Neighborhood Hits	38
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KS6C1_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.117592 (rank : 185)
Query Neighborhood Hits	217	Target Neighborhood Hits	700	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KSR1_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.061607 (rank : 673)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 466)	NC score	0.064100 (rank : 639)
Query Neighborhood Hits	217	Target Neighborhood Hits	870	Shared Neighborhood Hits	54
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSYK_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.056078 (rank : 770)
Query Neighborhood Hits	217	Target Neighborhood Hits	901	Shared Neighborhood Hits	48
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.055673 (rank : 777)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	48
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LATS1_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.111760 (rank : 203)
Query Neighborhood Hits	217	Target Neighborhood Hits	1057	Shared Neighborhood Hits	44
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.111871 (rank : 200)
Query Neighborhood Hits	217	Target Neighborhood Hits	1027	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

LATS2_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.110530 (rank : 213)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.111480 (rank : 205)
Query Neighborhood Hits	217	Target Neighborhood Hits	879	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

LCK_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.050876 (rank : 854)
Query Neighborhood Hits	217	Target Neighborhood Hits	981	Shared Neighborhood Hits	53
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LIMK1_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.059485 (rank : 703)
Query Neighborhood Hits	217	Target Neighborhood Hits	1005	Shared Neighborhood Hits	39
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.058743 (rank : 720)
Query Neighborhood Hits	217	Target Neighborhood Hits	1008	Shared Neighborhood Hits	39
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.057908 (rank : 732)
Query Neighborhood Hits	217	Target Neighborhood Hits	986	Shared Neighborhood Hits	39
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.057702 (rank : 740)
Query Neighborhood Hits	217	Target Neighborhood Hits	998	Shared Neighborhood Hits	41
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRRK1_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.062437 (rank : 657)
Query Neighborhood Hits	217	Target Neighborhood Hits	1237	Shared Neighborhood Hits	38
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.058891 (rank : 715)
Query Neighborhood Hits	217	Target Neighborhood Hits	1267	Shared Neighborhood Hits	37
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.055422 (rank : 782)
Query Neighborhood Hits	217	Target Neighborhood Hits	1382	Shared Neighborhood Hits	39
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.052540 (rank : 829)
Query Neighborhood Hits	217	Target Neighborhood Hits	1359	Shared Neighborhood Hits	39
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LYN_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.055621 (rank : 780)
Query Neighborhood Hits	217	Target Neighborhood Hits	1022	Shared Neighborhood Hits	54
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.055220 (rank : 787)
Query Neighborhood Hits	217	Target Neighborhood Hits	1023	Shared Neighborhood Hits	54
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.069314 (rank : 533)
Query Neighborhood Hits	217	Target Neighborhood Hits	1071	Shared Neighborhood Hits	55
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.075537 (rank : 460)
Query Neighborhood Hits	217	Target Neighborhood Hits	1136	Shared Neighborhood Hits	56
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.059041 (rank : 710)
Query Neighborhood Hits	217	Target Neighborhood Hits	940	Shared Neighborhood Hits	41
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.058978 (rank : 713)
Query Neighborhood Hits	217	Target Neighborhood Hits	957	Shared Neighborhood Hits	41
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.061809 (rank : 671)
Query Neighborhood Hits	217	Target Neighborhood Hits	911	Shared Neighborhood Hits	42
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K14_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.080824 (rank : 373)
Query Neighborhood Hits	217	Target Neighborhood Hits	887	Shared Neighborhood Hits	42
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M3K14_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.080069 (rank : 381)
Query Neighborhood Hits	217	Target Neighborhood Hits	889	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

M3K15_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.070752 (rank : 509)
Query Neighborhood Hits	217	Target Neighborhood Hits	914	Shared Neighborhood Hits	39
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.069520 (rank : 531)
Query Neighborhood Hits	217	Target Neighborhood Hits	952	Shared Neighborhood Hits	40
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.068902 (rank : 539)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.067143 (rank : 574)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.069222 (rank : 536)
Query Neighborhood Hits	217	Target Neighborhood Hits	885	Shared Neighborhood Hits	41
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.069221 (rank : 537)
Query Neighborhood Hits	217	Target Neighborhood Hits	876	Shared Neighborhood Hits	39
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.066898 (rank : 578)
Query Neighborhood Hits	217	Target Neighborhood Hits	911	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.066591 (rank : 582)
Query Neighborhood Hits	217	Target Neighborhood Hits	924	Shared Neighborhood Hits	40
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.070383 (rank : 518)
Query Neighborhood Hits	217	Target Neighborhood Hits	868	Shared Neighborhood Hits	39
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.070485 (rank : 514)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.072364 (rank : 488)
Query Neighborhood Hits	217	Target Neighborhood Hits	889	Shared Neighborhood Hits	40
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K7_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.056694 (rank : 760)
Query Neighborhood Hits	217	Target Neighborhood Hits	892	Shared Neighborhood Hits	39
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.056771 (rank : 758)
Query Neighborhood Hits	217	Target Neighborhood Hits	892	Shared Neighborhood Hits	39
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.063800 (rank : 643)
Query Neighborhood Hits	217	Target Neighborhood Hits	807	Shared Neighborhood Hits	39
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.064803 (rank : 624)
Query Neighborhood Hits	217	Target Neighborhood Hits	815	Shared Neighborhood Hits	39
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K9_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.069497 (rank : 532)
Query Neighborhood Hits	217	Target Neighborhood Hits	1123	Shared Neighborhood Hits	58
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.066936 (rank : 576)
Query Neighborhood Hits	217	Target Neighborhood Hits	1087	Shared Neighborhood Hits	55
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K1_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.068120 (rank : 552)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.067337 (rank : 570)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.071490 (rank : 501)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	39
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.071349 (rank : 503)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K3_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.072251 (rank : 490)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K4_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.065875 (rank : 600)
Query Neighborhood Hits	217	Target Neighborhood Hits	1589	Shared Neighborhood Hits	55
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.064523 (rank : 635)
Query Neighborhood Hits	217	Target Neighborhood Hits	1560	Shared Neighborhood Hits	51
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K5_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.068791 (rank : 543)
Query Neighborhood Hits	217	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M4K5_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.069007 (rank : 538)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MAK_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.059293 (rank : 707)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.059472 (rank : 704)
Query Neighborhood Hits	217	Target Neighborhood Hits	873	Shared Neighborhood Hits	40
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAPK2_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.078689 (rank : 406)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	39
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.078219 (rank : 416)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	39
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK3_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.078510 (rank : 407)
Query Neighborhood Hits	217	Target Neighborhood Hits	807	Shared Neighborhood Hits	39
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MAPK3_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.078356 (rank : 410)
Query Neighborhood Hits	217	Target Neighborhood Hits	811	Shared Neighborhood Hits	39
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAPK5_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.082687 (rank : 343)
Query Neighborhood Hits	217	Target Neighborhood Hits	795	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.082658 (rank : 344)
Query Neighborhood Hits	217	Target Neighborhood Hits	799	Shared Neighborhood Hits	39
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MARK1_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.078716 (rank : 405)
Query Neighborhood Hits	217	Target Neighborhood Hits	887	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.078975 (rank : 400)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.079721 (rank : 384)
Query Neighborhood Hits	217	Target Neighborhood Hits	1056	Shared Neighborhood Hits	43
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.080098 (rank : 379)
Query Neighborhood Hits	217	Target Neighborhood Hits	1018	Shared Neighborhood Hits	43
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.079253 (rank : 392)
Query Neighborhood Hits	217	Target Neighborhood Hits	893	Shared Neighborhood Hits	40
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.078743 (rank : 404)
Query Neighborhood Hits	217	Target Neighborhood Hits	919	Shared Neighborhood Hits	40
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.079082 (rank : 394)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	40
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.079068 (rank : 395)
Query Neighborhood Hits	217	Target Neighborhood Hits	898	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MAST1_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.104346 (rank : 240)
Query Neighborhood Hits	217	Target Neighborhood Hits	1146	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.104103 (rank : 243)
Query Neighborhood Hits	217	Target Neighborhood Hits	1123	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.101587 (rank : 251)
Query Neighborhood Hits	217	Target Neighborhood Hits	1189	Shared Neighborhood Hits	44
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.101455 (rank : 252)
Query Neighborhood Hits	217	Target Neighborhood Hits	1110	Shared Neighborhood Hits	42
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.103494 (rank : 246)
Query Neighborhood Hits	217	Target Neighborhood Hits	1128	Shared Neighborhood Hits	43
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST4_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.102739 (rank : 248)
Query Neighborhood Hits	217	Target Neighborhood Hits	1804	Shared Neighborhood Hits	58
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MASTL_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.100578 (rank : 261)
Query Neighborhood Hits	217	Target Neighborhood Hits	894	Shared Neighborhood Hits	39
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.100183 (rank : 262)
Query Neighborhood Hits	217	Target Neighborhood Hits	862	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MATK_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.052019 (rank : 834)
Query Neighborhood Hits	217	Target Neighborhood Hits	954	Shared Neighborhood Hits	50
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.052942 (rank : 820)
Query Neighborhood Hits	217	Target Neighborhood Hits	952	Shared Neighborhood Hits	49
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MELK_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.080886 (rank : 372)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.080739 (rank : 375)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MINK1_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.065533 (rank : 607)
Query Neighborhood Hits	217	Target Neighborhood Hits	1477	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.065575 (rank : 605)
Query Neighborhood Hits	217	Target Neighborhood Hits	1451	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK01_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.052736 (rank : 824)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.052704 (rank : 826)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.052411 (rank : 831)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.052695 (rank : 828)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK04_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.051323 (rank : 844)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK06_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.051808 (rank : 838)
Query Neighborhood Hits	217	Target Neighborhood Hits	815	Shared Neighborhood Hits	41
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.051097 (rank : 848)
Query Neighborhood Hits	217	Target Neighborhood Hits	818	Shared Neighborhood Hits	41
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK07_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.054388 (rank : 803)
Query Neighborhood Hits	217	Target Neighborhood Hits	1087	Shared Neighborhood Hits	43
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.054469 (rank : 801)
Query Neighborhood Hits	217	Target Neighborhood Hits	1054	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK08_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.057145 (rank : 749)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.057199 (rank : 747)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK09_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.056605 (rank : 762)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK09_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.056116 (rank : 768)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK10_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.055980 (rank : 774)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.055358 (rank : 784)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK11_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.054985 (rank : 792)
Query Neighborhood Hits	217	Target Neighborhood Hits	823	Shared Neighborhood Hits	39
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MK11_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.055635 (rank : 779)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK12_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.055671 (rank : 778)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.053585 (rank : 811)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK13_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.054540 (rank : 800)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.055224 (rank : 786)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.054617 (rank : 796)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.055127 (rank : 789)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK15_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.059849 (rank : 698)
Query Neighborhood Hits	217	Target Neighborhood Hits	1038	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK15_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.061327 (rank : 680)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MKNK1_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.087028 (rank : 304)
Query Neighborhood Hits	217	Target Neighborhood Hits	701	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK1_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.085104 (rank : 310)
Query Neighborhood Hits	217	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK2_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.082507 (rank : 348)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK2_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.082727 (rank : 342)
Query Neighborhood Hits	217	Target Neighborhood Hits	819	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MLTK_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.061290 (rank : 681)
Query Neighborhood Hits	217	Target Neighborhood Hits	911	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.061548 (rank : 675)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOK_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.053057 (rank : 815)
Query Neighborhood Hits	217	Target Neighborhood Hits	807	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MOK_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.052699 (rank : 827)
Query Neighborhood Hits	217	Target Neighborhood Hits	796	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MOS_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.061373 (rank : 678)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 581)	NC score	0.057529 (rank : 744)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K1_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.071631 (rank : 497)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	38
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 583)	NC score	0.071606 (rank : 498)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	38
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.071919 (rank : 494)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 585)	NC score	0.071491 (rank : 500)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.064959 (rank : 618)
Query Neighborhood Hits	217	Target Neighborhood Hits	825	Shared Neighborhood Hits	38
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.067980 (rank : 556)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	38
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 588)	NC score	0.064806 (rank : 623)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 589)	NC score	0.064907 (rank : 620)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.068802 (rank : 541)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 591)	NC score	0.070889 (rank : 507)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 592)	NC score	0.063158 (rank : 649)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.062257 (rank : 663)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.073660 (rank : 475)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.067937 (rank : 558)
Query Neighborhood Hits	217	Target Neighborhood Hits	852	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.067974 (rank : 557)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYLK2_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.079024 (rank : 397)
Query Neighborhood Hits	217	Target Neighborhood Hits	920	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYLK_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.069707 (rank : 528)
Query Neighborhood Hits	217	Target Neighborhood Hits	1328	Shared Neighborhood Hits	42
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
θ value	θ > 10 (rank : 599)	NC score	0.070123 (rank : 521)
Query Neighborhood Hits	217	Target Neighborhood Hits	1489	Shared Neighborhood Hits	41
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYO3A_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.062387 (rank : 659)
Query Neighborhood Hits	217	Target Neighborhood Hits	1033	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.062264 (rank : 662)
Query Neighborhood Hits	217	Target Neighborhood Hits	902	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3B_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.064933 (rank : 619)
Query Neighborhood Hits	217	Target Neighborhood Hits	923	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

NEK11_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.072790 (rank : 485)
Query Neighborhood Hits	217	Target Neighborhood Hits	1043	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.071875 (rank : 495)
Query Neighborhood Hits	217	Target Neighborhood Hits	875	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.071754 (rank : 496)
Query Neighborhood Hits	217	Target Neighborhood Hits	1129	Shared Neighborhood Hits	48
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.072192 (rank : 491)
Query Neighborhood Hits	217	Target Neighborhood Hits	1311	Shared Neighborhood Hits	53
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.070908 (rank : 506)
Query Neighborhood Hits	217	Target Neighborhood Hits	908	Shared Neighborhood Hits	39
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.072676 (rank : 486)
Query Neighborhood Hits	217	Target Neighborhood Hits	876	Shared Neighborhood Hits	39
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.077647 (rank : 422)
Query Neighborhood Hits	217	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.079035 (rank : 396)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.074319 (rank : 470)
Query Neighborhood Hits	217	Target Neighborhood Hits	883	Shared Neighborhood Hits	40
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.074055 (rank : 471)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.065957 (rank : 596)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.065797 (rank : 602)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.064637 (rank : 631)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 616)	NC score	0.064883 (rank : 621)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.067721 (rank : 563)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.067615 (rank : 565)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.070586 (rank : 512)
Query Neighborhood Hits	217	Target Neighborhood Hits	900	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.071015 (rank : 504)
Query Neighborhood Hits	217	Target Neighborhood Hits	890	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NGAP_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.054998 (rank : 791)
Query Neighborhood Hits	217	Target Neighborhood Hits	517	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

NIM1_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.081790 (rank : 360)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.081238 (rank : 366)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NLK_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.052953 (rank : 818)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.052952 (rank : 819)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NRK_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.064683 (rank : 630)
Query Neighborhood Hits	217	Target Neighborhood Hits	931	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.066303 (rank : 590)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NUAK1_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.079690 (rank : 386)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.079697 (rank : 385)
Query Neighborhood Hits	217	Target Neighborhood Hits	881	Shared Neighborhood Hits	39
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.082172 (rank : 353)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.084035 (rank : 319)
Query Neighborhood Hits	217	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

OBSCN_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.067483 (rank : 568)
Query Neighborhood Hits	217	Target Neighborhood Hits	1931	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OPHN1_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.050748 (rank : 857)
Query Neighborhood Hits	217	Target Neighborhood Hits	161	Shared Neighborhood Hits	16
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OXSR1_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.065953 (rank : 597)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 635)	NC score	0.066419 (rank : 589)
Query Neighborhood Hits	217	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

P3C2G_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.052414 (rank : 830)
Query Neighborhood Hits	217	Target Neighborhood Hits	113	Shared Neighborhood Hits	49
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PA24C_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.099099 (rank : 266)
Query Neighborhood Hits	217	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UP65, O75457, Q9UG68	Gene names	PLA2G4C
Domain Architecture
Description	Cytosolic phospholipase A2 gamma precursor (EC 3.1.1.4) (cPLA2-gamma) (Phospholipase A2 group IVC).

PAK1_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.070772 (rank : 508)
Query Neighborhood Hits	217	Target Neighborhood Hits	873	Shared Neighborhood Hits	42
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.070985 (rank : 505)
Query Neighborhood Hits	217	Target Neighborhood Hits	878	Shared Neighborhood Hits	42
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.070701 (rank : 510)
Query Neighborhood Hits	217	Target Neighborhood Hits	862	Shared Neighborhood Hits	39
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.070576 (rank : 513)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.070318 (rank : 520)
Query Neighborhood Hits	217	Target Neighborhood Hits	887	Shared Neighborhood Hits	40
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.070469 (rank : 516)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.073859 (rank : 472)
Query Neighborhood Hits	217	Target Neighborhood Hits	924	Shared Neighborhood Hits	40
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.074361 (rank : 469)
Query Neighborhood Hits	217	Target Neighborhood Hits	1098	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.071600 (rank : 499)
Query Neighborhood Hits	217	Target Neighborhood Hits	915	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 647)	NC score	0.073376 (rank : 478)
Query Neighborhood Hits	217	Target Neighborhood Hits	875	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 648)	NC score	0.072818 (rank : 484)
Query Neighborhood Hits	217	Target Neighborhood Hits	875	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PASK_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.079894 (rank : 383)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PASK_MOUSE
θ value	θ > 10 (rank : 650)	NC score	0.079997 (rank : 382)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PCTK1_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.063150 (rank : 650)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.063252 (rank : 648)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_HUMAN
θ value	θ > 10 (rank : 653)	NC score	0.062330 (rank : 661)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	θ > 10 (rank : 654)	NC score	0.062336 (rank : 660)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.062014 (rank : 666)
Query Neighborhood Hits	217	Target Neighborhood Hits	827	Shared Neighborhood Hits	39
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.062499 (rank : 655)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PDK1L_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.075716 (rank : 457)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 658)	NC score	0.075471 (rank : 462)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDPK1_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.095808 (rank : 280)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	θ > 10 (rank : 660)	NC score	0.096017 (rank : 279)
Query Neighborhood Hits	217	Target Neighborhood Hits	852	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PFTK1_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.065337 (rank : 610)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 662)	NC score	0.065866 (rank : 601)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PHKG1_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.078221 (rank : 415)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG1_MOUSE
θ value	θ > 10 (rank : 664)	NC score	0.079400 (rank : 390)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.077284 (rank : 425)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PHKG2_MOUSE
θ value	θ > 10 (rank : 666)	NC score	0.077033 (rank : 435)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PIM1_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.077375 (rank : 424)
Query Neighborhood Hits	217	Target Neighborhood Hits	797	Shared Neighborhood Hits	39
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_MOUSE
θ value	θ > 10 (rank : 668)	NC score	0.079262 (rank : 391)
Query Neighborhood Hits	217	Target Neighborhood Hits	787	Shared Neighborhood Hits	39
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM2_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.082424 (rank : 350)
Query Neighborhood Hits	217	Target Neighborhood Hits	808	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PIM2_MOUSE
θ value	θ > 10 (rank : 670)	NC score	0.084003 (rank : 320)
Query Neighborhood Hits	217	Target Neighborhood Hits	809	Shared Neighborhood Hits	39
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PIM3_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.081859 (rank : 358)
Query Neighborhood Hits	217	Target Neighborhood Hits	789	Shared Neighborhood Hits	39
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.082543 (rank : 347)
Query Neighborhood Hits	217	Target Neighborhood Hits	783	Shared Neighborhood Hits	39
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PINK1_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.075959 (rank : 451)
Query Neighborhood Hits	217	Target Neighborhood Hits	741	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PINK1_MOUSE
θ value	θ > 10 (rank : 674)	NC score	0.082606 (rank : 346)
Query Neighborhood Hits	217	Target Neighborhood Hits	726	Shared Neighborhood Hits	38
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKN1_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.114513 (rank : 191)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	40
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 676)	NC score	0.114591 (rank : 190)
Query Neighborhood Hits	217	Target Neighborhood Hits	888	Shared Neighborhood Hits	40
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.113515 (rank : 192)
Query Neighborhood Hits	217	Target Neighborhood Hits	892	Shared Neighborhood Hits	39
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 678)	NC score	0.113312 (rank : 193)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.114613 (rank : 189)
Query Neighborhood Hits	217	Target Neighborhood Hits	893	Shared Neighborhood Hits	42
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 680)	NC score	0.112813 (rank : 195)
Query Neighborhood Hits	217	Target Neighborhood Hits	1009	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLCD1_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.081156 (rank : 369)
Query Neighborhood Hits	217	Target Neighborhood Hits	93	Shared Neighborhood Hits	53
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.055679 (rank : 776)
Query Neighborhood Hits	217	Target Neighborhood Hits	106	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLK1_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.082149 (rank : 355)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 684)	NC score	0.082170 (rank : 354)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.079238 (rank : 393)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.078979 (rank : 399)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.077630 (rank : 423)
Query Neighborhood Hits	217	Target Neighborhood Hits	865	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.076961 (rank : 439)
Query Neighborhood Hits	217	Target Neighborhood Hits	863	Shared Neighborhood Hits	39
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.080071 (rank : 380)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 690)	NC score	0.080187 (rank : 378)
Query Neighborhood Hits	217	Target Neighborhood Hits	879	Shared Neighborhood Hits	39
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PMYT1_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.078950 (rank : 402)
Query Neighborhood Hits	217	Target Neighborhood Hits	814	Shared Neighborhood Hits	39
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PMYT1_MOUSE
θ value	θ > 10 (rank : 692)	NC score	0.078235 (rank : 414)
Query Neighborhood Hits	217	Target Neighborhood Hits	910	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PRKX_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.100998 (rank : 256)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
θ value	θ > 10 (rank : 694)	NC score	0.101116 (rank : 255)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.095420 (rank : 282)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	39
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PRP4B_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.063147 (rank : 651)
Query Neighborhood Hits	217	Target Neighborhood Hits	1030	Shared Neighborhood Hits	46
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.062388 (rank : 658)
Query Neighborhood Hits	217	Target Neighborhood Hits	1040	Shared Neighborhood Hits	47
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PTK6_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.053814 (rank : 808)
Query Neighborhood Hits	217	Target Neighborhood Hits	1020	Shared Neighborhood Hits	54
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.056539 (rank : 763)
Query Neighborhood Hits	217	Target Neighborhood Hits	1026	Shared Neighborhood Hits	54
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PXK_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.070476 (rank : 515)
Query Neighborhood Hits	217	Target Neighborhood Hits	216	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.067079 (rank : 575)
Query Neighborhood Hits	217	Target Neighborhood Hits	320	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RASA1_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.077113 (rank : 432)
Query Neighborhood Hits	217	Target Neighborhood Hits	258	Shared Neighborhood Hits	33
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF3_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.056659 (rank : 761)
Query Neighborhood Hits	217	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q86WH2, Q86WH1	Gene names	RASSF3
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 3.

RASF3_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.056763 (rank : 759)
Query Neighborhood Hits	217	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q99P51, Q3TJ17	Gene names	Rassf3
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 3.

RFIP5_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.090161 (rank : 296)
Query Neighborhood Hits	217	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BXF6, O94939, Q9P0M1	Gene names	RAB11FIP5, GAF1, KIAA0857, RIP11
Domain Architecture
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75).

RFIP5_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.083863 (rank : 321)
Query Neighborhood Hits	217	Target Neighborhood Hits	126	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

RGAP1_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.091587 (rank : 294)
Query Neighborhood Hits	217	Target Neighborhood Hits	185	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGS3_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.096882 (rank : 272)
Query Neighborhood Hits	217	Target Neighborhood Hits	1375	Shared Neighborhood Hits	73
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RHG04_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.055355 (rank : 785)
Query Neighborhood Hits	217	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG09_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.058956 (rank : 714)
Query Neighborhood Hits	217	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.056978 (rank : 754)
Query Neighborhood Hits	217	Target Neighborhood Hits	190	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 712)	NC score	0.059731 (rank : 700)
Query Neighborhood Hits	217	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG25_MOUSE
θ value	θ > 10 (rank : 713)	NC score	0.051032 (rank : 849)
Query Neighborhood Hits	217	Target Neighborhood Hits	492	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG26_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.058137 (rank : 728)
Query Neighborhood Hits	217	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMS3_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.170938 (rank : 153)
Query Neighborhood Hits	217	Target Neighborhood Hits	66	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.165226 (rank : 155)
Query Neighborhood Hits	217	Target Neighborhood Hits	67	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.183212 (rank : 135)
Query Neighborhood Hits	217	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.184031 (rank : 132)
Query Neighborhood Hits	217	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIPK1_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.058816 (rank : 718)
Query Neighborhood Hits	217	Target Neighborhood Hits	891	Shared Neighborhood Hits	40
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.058188 (rank : 726)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.062244 (rank : 664)
Query Neighborhood Hits	217	Target Neighborhood Hits	774	Shared Neighborhood Hits	39
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 722)	NC score	0.065564 (rank : 606)
Query Neighborhood Hits	217	Target Neighborhood Hits	776	Shared Neighborhood Hits	39
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.067907 (rank : 559)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.069530 (rank : 530)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK5_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.078504 (rank : 408)
Query Neighborhood Hits	217	Target Neighborhood Hits	864	Shared Neighborhood Hits	41
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 726)	NC score	0.078752 (rank : 403)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RK_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.107021 (rank : 225)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

RK_MOUSE
θ value	θ > 10 (rank : 728)	NC score	0.103557 (rank : 245)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ROCK1_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.099517 (rank : 263)
Query Neighborhood Hits	217	Target Neighborhood Hits	2000	Shared Neighborhood Hits	65
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.097625 (rank : 271)
Query Neighborhood Hits	217	Target Neighborhood Hits	2126	Shared Neighborhood Hits	66
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RPKL1_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.123075 (rank : 181)
Query Neighborhood Hits	217	Target Neighborhood Hits	708	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.122837 (rank : 182)
Query Neighborhood Hits	217	Target Neighborhood Hits	704	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

SBK1_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.083347 (rank : 328)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.082402 (rank : 351)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SCYL2_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.067322 (rank : 571)
Query Neighborhood Hits	217	Target Neighborhood Hits	632	Shared Neighborhood Hits	37
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.068659 (rank : 544)
Query Neighborhood Hits	217	Target Neighborhood Hits	603	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SGK1_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.111158 (rank : 208)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	39
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.111404 (rank : 206)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.112599 (rank : 197)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK2_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.111784 (rank : 202)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK3_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.111810 (rank : 201)
Query Neighborhood Hits	217	Target Neighborhood Hits	877	Shared Neighborhood Hits	42
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.111498 (rank : 204)
Query Neighborhood Hits	217	Target Neighborhood Hits	882	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SLK_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.065966 (rank : 595)
Query Neighborhood Hits	217	Target Neighborhood Hits	1775	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.066212 (rank : 593)
Query Neighborhood Hits	217	Target Neighborhood Hits	1798	Shared Neighborhood Hits	61
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SN1L1_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.077125 (rank : 431)
Query Neighborhood Hits	217	Target Neighborhood Hits	911	Shared Neighborhood Hits	40
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.075936 (rank : 453)
Query Neighborhood Hits	217	Target Neighborhood Hits	895	Shared Neighborhood Hits	41
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.076831 (rank : 441)
Query Neighborhood Hits	217	Target Neighborhood Hits	964	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 748)	NC score	0.077248 (rank : 426)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNRK_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.077146 (rank : 430)
Query Neighborhood Hits	217	Target Neighborhood Hits	855	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.076006 (rank : 449)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SPEG_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.068796 (rank : 542)
Query Neighborhood Hits	217	Target Neighborhood Hits	1762	Shared Neighborhood Hits	52
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
θ value	θ > 10 (rank : 752)	NC score	0.066624 (rank : 580)
Query Neighborhood Hits	217	Target Neighborhood Hits	1959	Shared Neighborhood Hits	54
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SRC_HUMAN
θ value	θ > 10 (rank : 753)	NC score	0.053347 (rank : 812)
Query Neighborhood Hits	217	Target Neighborhood Hits	1058	Shared Neighborhood Hits	56
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.053248 (rank : 813)
Query Neighborhood Hits	217	Target Neighborhood Hits	1033	Shared Neighborhood Hits	56
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP1_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.053110 (rank : 814)
Query Neighborhood Hits	217	Target Neighborhood Hits	390	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.050259 (rank : 860)
Query Neighborhood Hits	217	Target Neighborhood Hits	331	Shared Neighborhood Hits	30
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 757)	NC score	0.050105 (rank : 864)
Query Neighborhood Hits	217	Target Neighborhood Hits	324	Shared Neighborhood Hits	30
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 758)	NC score	0.050121 (rank : 863)
Query Neighborhood Hits	217	Target Neighborhood Hits	946	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 759)	NC score	0.052346 (rank : 832)
Query Neighborhood Hits	217	Target Neighborhood Hits	964	Shared Neighborhood Hits	52
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ST17A_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.085413 (rank : 308)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.084702 (rank : 312)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 762)	NC score	0.082750 (rank : 339)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST32A_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.098028 (rank : 268)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

ST32A_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.096749 (rank : 273)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

ST32B_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.099400 (rank : 265)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32B_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.098765 (rank : 267)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32C_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.101152 (rank : 254)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.100726 (rank : 258)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ST38L_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.109479 (rank : 216)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST38L_MOUSE
θ value	θ > 10 (rank : 770)	NC score	0.110359 (rank : 214)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK10_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.068335 (rank : 547)
Query Neighborhood Hits	217	Target Neighborhood Hits	1921	Shared Neighborhood Hits	59
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	θ > 10 (rank : 772)	NC score	0.066636 (rank : 579)
Query Neighborhood Hits	217	Target Neighborhood Hits	2132	Shared Neighborhood Hits	60
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.076490 (rank : 446)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	39
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK16_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.064554 (rank : 634)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 775)	NC score	0.057870 (rank : 735)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.067453 (rank : 569)
Query Neighborhood Hits	217	Target Neighborhood Hits	853	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.067589 (rank : 566)
Query Neighborhood Hits	217	Target Neighborhood Hits	856	Shared Neighborhood Hits	39
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.068128 (rank : 551)
Query Neighborhood Hits	217	Target Neighborhood Hits	853	Shared Neighborhood Hits	39
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 779)	NC score	0.068101 (rank : 554)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 780)	NC score	0.080271 (rank : 377)
Query Neighborhood Hits	217	Target Neighborhood Hits	879	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.070009 (rank : 524)
Query Neighborhood Hits	217	Target Neighborhood Hits	825	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.075949 (rank : 452)
Query Neighborhood Hits	217	Target Neighborhood Hits	896	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 783)	NC score	0.075601 (rank : 459)
Query Neighborhood Hits	217	Target Neighborhood Hits	877	Shared Neighborhood Hits	39
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK38_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.109300 (rank : 217)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.109185 (rank : 218)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK39_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.066481 (rank : 585)
Query Neighborhood Hits	217	Target Neighborhood Hits	882	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.066594 (rank : 581)
Query Neighborhood Hits	217	Target Neighborhood Hits	915	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.065623 (rank : 604)
Query Neighborhood Hits	217	Target Neighborhood Hits	861	Shared Neighborhood Hits	39
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 789)	NC score	0.065403 (rank : 608)
Query Neighborhood Hits	217	Target Neighborhood Hits	869	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK40_HUMAN
θ value	θ > 10 (rank : 790)	NC score	0.093025 (rank : 290)
Query Neighborhood Hits	217	Target Neighborhood Hits	751	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	θ > 10 (rank : 791)	NC score	0.093118 (rank : 288)
Query Neighborhood Hits	217	Target Neighborhood Hits	751	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STK4_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.064707 (rank : 628)
Query Neighborhood Hits	217	Target Neighborhood Hits	870	Shared Neighborhood Hits	39
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 793)	NC score	0.064796 (rank : 625)
Query Neighborhood Hits	217	Target Neighborhood Hits	873	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.081804 (rank : 359)
Query Neighborhood Hits	217	Target Neighborhood Hits	916	Shared Neighborhood Hits	43
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 795)	NC score	0.081775 (rank : 361)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	41
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STYK1_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.054702 (rank : 795)
Query Neighborhood Hits	217	Target Neighborhood Hits	786	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 797)	NC score	0.051191 (rank : 846)
Query Neighborhood Hits	217	Target Neighborhood Hits	779	Shared Neighborhood Hits	39
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SYGP1_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.050824 (rank : 855)
Query Neighborhood Hits	217	Target Neighborhood Hits	589	Shared Neighborhood Hits	28
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

SYT12_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.246618 (rank : 89)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT12_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.251498 (rank : 86)
Query Neighborhood Hits	217	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT13_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.198905 (rank : 119)
Query Neighborhood Hits	217	Target Neighborhood Hits	76	Shared Neighborhood Hits	55
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.195101 (rank : 123)
Query Neighborhood Hits	217	Target Neighborhood Hits	69	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT14_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.176031 (rank : 148)
Query Neighborhood Hits	217	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_MOUSE
θ value	θ > 10 (rank : 804)	NC score	0.182408 (rank : 136)
Query Neighborhood Hits	217	Target Neighborhood Hits	82	Shared Neighborhood Hits	49
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT8_MOUSE
θ value	θ > 10 (rank : 805)	NC score	0.243150 (rank : 93)
Query Neighborhood Hits	217	Target Neighborhood Hits	94	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYTL1_MOUSE
θ value	θ > 10 (rank : 806)	NC score	0.239265 (rank : 96)
Query Neighborhood Hits	217	Target Neighborhood Hits	314	Shared Neighborhood Hits	82
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL3_MOUSE
θ value	θ > 10 (rank : 807)	NC score	0.225789 (rank : 109)
Query Neighborhood Hits	217	Target Neighborhood Hits	110	Shared Neighborhood Hits	67
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	θ > 10 (rank : 808)	NC score	0.253593 (rank : 80)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	77
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.252286 (rank : 83)
Query Neighborhood Hits	217	Target Neighborhood Hits	137	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.250400 (rank : 87)
Query Neighborhood Hits	217	Target Neighborhood Hits	237	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TAC2N_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.095004 (rank : 285)
Query Neighborhood Hits	217	Target Neighborhood Hits	47	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.092708 (rank : 291)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	29
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAOK1_HUMAN
θ value	θ > 10 (rank : 813)	NC score	0.057783 (rank : 737)
Query Neighborhood Hits	217	Target Neighborhood Hits	1734	Shared Neighborhood Hits	56
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 814)	NC score	0.057873 (rank : 734)
Query Neighborhood Hits	217	Target Neighborhood Hits	1720	Shared Neighborhood Hits	57
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	θ > 10 (rank : 815)	NC score	0.059497 (rank : 702)
Query Neighborhood Hits	217	Target Neighborhood Hits	1172	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 816)	NC score	0.060326 (rank : 693)
Query Neighborhood Hits	217	Target Neighborhood Hits	1373	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK3_HUMAN
θ value	θ > 10 (rank : 817)	NC score	0.057828 (rank : 736)
Query Neighborhood Hits	217	Target Neighborhood Hits	1494	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	θ > 10 (rank : 818)	NC score	0.058792 (rank : 719)
Query Neighborhood Hits	217	Target Neighborhood Hits	1458	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TBK1_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.073193 (rank : 479)
Query Neighborhood Hits	217	Target Neighborhood Hits	861	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 820)	NC score	0.073679 (rank : 474)
Query Neighborhood Hits	217	Target Neighborhood Hits	893	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TCGAP_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.056882 (rank : 755)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	32
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.062679 (rank : 654)
Query Neighborhood Hits	217	Target Neighborhood Hits	409	Shared Neighborhood Hits	29
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TEC_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.064210 (rank : 638)
Query Neighborhood Hits	217	Target Neighborhood Hits	1006	Shared Neighborhood Hits	60
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 824)	NC score	0.063078 (rank : 652)
Query Neighborhood Hits	217	Target Neighborhood Hits	1006	Shared Neighborhood Hits	58
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK1_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.057693 (rank : 741)
Query Neighborhood Hits	217	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 826)	NC score	0.058515 (rank : 723)
Query Neighborhood Hits	217	Target Neighborhood Hits	862	Shared Neighborhood Hits	39
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 827)	NC score	0.059562 (rank : 701)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 828)	NC score	0.058065 (rank : 729)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TITIN_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.061981 (rank : 667)
Query Neighborhood Hits	217	Target Neighborhood Hits	2923	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TLK1_HUMAN
θ value	θ > 10 (rank : 830)	NC score	0.067302 (rank : 572)
Query Neighborhood Hits	217	Target Neighborhood Hits	967	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	θ > 10 (rank : 831)	NC score	0.067181 (rank : 573)
Query Neighborhood Hits	217	Target Neighborhood Hits	947	Shared Neighborhood Hits	43
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	θ > 10 (rank : 832)	NC score	0.068113 (rank : 553)
Query Neighborhood Hits	217	Target Neighborhood Hits	1044	Shared Neighborhood Hits	47
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 833)	NC score	0.067647 (rank : 564)
Query Neighborhood Hits	217	Target Neighborhood Hits	1088	Shared Neighborhood Hits	50
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TNI3K_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.058029 (rank : 730)
Query Neighborhood Hits	217	Target Neighborhood Hits	1084	Shared Neighborhood Hits	40
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 835)	NC score	0.059037 (rank : 711)
Query Neighborhood Hits	217	Target Neighborhood Hits	1079	Shared Neighborhood Hits	40
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 836)	NC score	0.064583 (rank : 632)
Query Neighborhood Hits	217	Target Neighborhood Hits	1570	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TRIB1_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.090005 (rank : 297)
Query Neighborhood Hits	217	Target Neighborhood Hits	598	Shared Neighborhood Hits	38
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
θ value	θ > 10 (rank : 838)	NC score	0.088845 (rank : 302)
Query Neighborhood Hits	217	Target Neighborhood Hits	593	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB2_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.085700 (rank : 306)
Query Neighborhood Hits	217	Target Neighborhood Hits	657	Shared Neighborhood Hits	39
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.085530 (rank : 307)
Query Neighborhood Hits	217	Target Neighborhood Hits	653	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB3_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.091939 (rank : 293)
Query Neighborhood Hits	217	Target Neighborhood Hits	519	Shared Neighborhood Hits	32
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB3_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.089240 (rank : 300)
Query Neighborhood Hits	217	Target Neighborhood Hits	578	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TRIO_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.081447 (rank : 363)
Query Neighborhood Hits	217	Target Neighborhood Hits	1580	Shared Neighborhood Hits	62
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TRIPC_HUMAN
θ value	θ > 10 (rank : 844)	NC score	0.059266 (rank : 708)
Query Neighborhood Hits	217	Target Neighborhood Hits	319	Shared Neighborhood Hits	11
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

TSSK1_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.082864 (rank : 337)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK1_MOUSE
θ value	θ > 10 (rank : 846)	NC score	0.078264 (rank : 412)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.082222 (rank : 352)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	39
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 848)	NC score	0.083335 (rank : 329)
Query Neighborhood Hits	217	Target Neighborhood Hits	819	Shared Neighborhood Hits	39
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK3_HUMAN
θ value	θ > 10 (rank : 849)	NC score	0.073703 (rank : 473)
Query Neighborhood Hits	217	Target Neighborhood Hits	806	Shared Neighborhood Hits	38
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK3_MOUSE
θ value	θ > 10 (rank : 850)	NC score	0.074615 (rank : 466)
Query Neighborhood Hits	217	Target Neighborhood Hits	806	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK4_HUMAN
θ value	θ > 10 (rank : 851)	NC score	0.083172 (rank : 332)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 852)	NC score	0.083398 (rank : 327)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.078036 (rank : 418)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.076921 (rank : 440)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TTK_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.069531 (rank : 529)
Query Neighborhood Hits	217	Target Neighborhood Hits	816	Shared Neighborhood Hits	40
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTK_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.069862 (rank : 526)
Query Neighborhood Hits	217	Target Neighborhood Hits	803	Shared Neighborhood Hits	39
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

TXK_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.057596 (rank : 743)
Query Neighborhood Hits	217	Target Neighborhood Hits	971	Shared Neighborhood Hits	51
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.055438 (rank : 781)
Query Neighborhood Hits	217	Target Neighborhood Hits	980	Shared Neighborhood Hits	51
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.051381 (rank : 843)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

UBE3A_HUMAN
θ value	θ > 10 (rank : 860)	NC score	0.069298 (rank : 534)
Query Neighborhood Hits	217	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 861)	NC score	0.068619 (rank : 545)
Query Neighborhood Hits	217	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.070346 (rank : 519)
Query Neighborhood Hits	217	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.069889 (rank : 525)
Query Neighborhood Hits	217	Target Neighborhood Hits	48	Shared Neighborhood Hits	9
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UHMK1_HUMAN
θ value	θ > 10 (rank : 864)	NC score	0.060686 (rank : 688)
Query Neighborhood Hits	217	Target Neighborhood Hits	808	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	θ > 10 (rank : 865)	NC score	0.060811 (rank : 686)
Query Neighborhood Hits	217	Target Neighborhood Hits	809	Shared Neighborhood Hits	39
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ULK1_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.075382 (rank : 463)
Query Neighborhood Hits	217	Target Neighborhood Hits	1121	Shared Neighborhood Hits	44
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.075508 (rank : 461)
Query Neighborhood Hits	217	Target Neighborhood Hits	1214	Shared Neighborhood Hits	42
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.075655 (rank : 458)
Query Neighborhood Hits	217	Target Neighborhood Hits	979	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 869)	NC score	0.076327 (rank : 447)
Query Neighborhood Hits	217	Target Neighborhood Hits	943	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 870)	NC score	0.076295 (rank : 448)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 871)	NC score	0.077238 (rank : 427)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK4_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.089938 (rank : 298)
Query Neighborhood Hits	217	Target Neighborhood Hits	793	Shared Neighborhood Hits	39
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

WEE1B_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.063377 (rank : 646)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	45
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1B_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.064002 (rank : 640)
Query Neighborhood Hits	217	Target Neighborhood Hits	765	Shared Neighborhood Hits	40
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

WEE1_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.056357 (rank : 764)
Query Neighborhood Hits	217	Target Neighborhood Hits	777	Shared Neighborhood Hits	42
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

WEE1_MOUSE
θ value	θ > 10 (rank : 876)	NC score	0.054396 (rank : 802)
Query Neighborhood Hits	217	Target Neighborhood Hits	794	Shared Neighborhood Hits	39
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

WNK1_HUMAN
θ value	θ > 10 (rank : 877)	NC score	0.068216 (rank : 549)
Query Neighborhood Hits	217	Target Neighborhood Hits	1158	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 878)	NC score	0.068448 (rank : 546)
Query Neighborhood Hits	217	Target Neighborhood Hits	1179	Shared Neighborhood Hits	46
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.066477 (rank : 586)
Query Neighborhood Hits	217	Target Neighborhood Hits	1407	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK3_HUMAN
θ value	θ > 10 (rank : 880)	NC score	0.070080 (rank : 522)
Query Neighborhood Hits	217	Target Neighborhood Hits	948	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK4_HUMAN
θ value	θ > 10 (rank : 881)	NC score	0.068198 (rank : 550)
Query Neighborhood Hits	217	Target Neighborhood Hits	1043	Shared Neighborhood Hits	44
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK4_MOUSE
θ value	θ > 10 (rank : 882)	NC score	0.067861 (rank : 562)
Query Neighborhood Hits	217	Target Neighborhood Hits	961	Shared Neighborhood Hits	42
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WWC1_HUMAN
θ value	θ > 10 (rank : 883)	NC score	0.064808 (rank : 622)
Query Neighborhood Hits	217	Target Neighborhood Hits	290	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 884)	NC score	0.080772 (rank : 374)
Query Neighborhood Hits	217	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWP1_HUMAN
θ value	θ > 10 (rank : 885)	NC score	0.085220 (rank : 309)
Query Neighborhood Hits	217	Target Neighborhood Hits	262	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 886)	NC score	0.084320 (rank : 318)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 887)	NC score	0.080665 (rank : 376)
Query Neighborhood Hits	217	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 888)	NC score	0.081363 (rank : 364)
Query Neighborhood Hits	217	Target Neighborhood Hits	118	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

YAP1_MOUSE
θ value	θ > 10 (rank : 889)	NC score	0.059345 (rank : 706)
Query Neighborhood Hits	217	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YES_HUMAN
θ value	θ > 10 (rank : 890)	NC score	0.052014 (rank : 835)
Query Neighborhood Hits	217	Target Neighborhood Hits	1059	Shared Neighborhood Hits	56
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 891)	NC score	0.052143 (rank : 833)
Query Neighborhood Hits	217	Target Neighborhood Hits	1052	Shared Neighborhood Hits	56
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YSK4_HUMAN
θ value	θ > 10 (rank : 892)	NC score	0.065292 (rank : 611)
Query Neighborhood Hits	217	Target Neighborhood Hits	921	Shared Neighborhood Hits	43
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 893)	NC score	0.057312 (rank : 745)
Query Neighborhood Hits	217	Target Neighborhood Hits	893	Shared Neighborhood Hits	47
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 894)	NC score	0.056231 (rank : 766)
Query Neighborhood Hits	217	Target Neighborhood Hits	905	Shared Neighborhood Hits	47
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

UN13B_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	217	Target Neighborhood Hits	217	Shared Neighborhood Hits	217
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
NC score	0.995018 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	217	Target Neighborhood Hits	210	Shared Neighborhood Hits	191
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13A_HUMAN
NC score	0.981221 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	217	Target Neighborhood Hits	285	Shared Neighborhood Hits	192
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13D_HUMAN
NC score	0.598864 (rank : 4)	θ value	1.85889e-29 (rank : 4)
Query Neighborhood Hits	217	Target Neighborhood Hits	117	Shared Neighborhood Hits	88
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

BAIP3_HUMAN
NC score	0.566815 (rank : 5)	θ value	2.87452e-22 (rank : 5)
Query Neighborhood Hits	217	Target Neighborhood Hits	108	Shared Neighborhood Hits	78
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
NC score	0.543478 (rank : 6)	θ value	5.99374e-20 (rank : 6)
Query Neighborhood Hits	217	Target Neighborhood Hits	112	Shared Neighborhood Hits	89
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

GRP3_HUMAN
NC score	0.448884 (rank : 7)	θ value	2.0648e-12 (rank : 13)
Query Neighborhood Hits	217	Target Neighborhood Hits	131	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

FA62A_MOUSE
NC score	0.443534 (rank : 8)	θ value	1.99992e-07 (rank : 33)
Query Neighborhood Hits	217	Target Neighborhood Hits	155	Shared Neighborhood Hits	110
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RASL2_HUMAN
NC score	0.432756 (rank : 9)	θ value	8.97725e-08 (rank : 32)
Query Neighborhood Hits	217	Target Neighborhood Hits	161	Shared Neighborhood Hits	109
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

FA62A_HUMAN
NC score	0.429873 (rank : 10)	θ value	3.77169e-06 (rank : 47)
Query Neighborhood Hits	217	Target Neighborhood Hits	168	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RASL1_HUMAN
NC score	0.422022 (rank : 11)	θ value	8.97725e-08 (rank : 31)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	107
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
NC score	0.410613 (rank : 12)	θ value	3.41135e-07 (rank : 40)
Query Neighborhood Hits	217	Target Neighborhood Hits	148	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

DOC2B_HUMAN
NC score	0.404190 (rank : 13)	θ value	1.09739e-05 (rank : 52)
Query Neighborhood Hits	217	Target Neighborhood Hits	150	Shared Neighborhood Hits	112
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
NC score	0.396340 (rank : 14)	θ value	0.00020696 (rank : 78)
Query Neighborhood Hits	217	Target Neighborhood Hits	169	Shared Neighborhood Hits	112
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_HUMAN
NC score	0.396174 (rank : 15)	θ value	0.00020696 (rank : 76)
Query Neighborhood Hits	217	Target Neighborhood Hits	144	Shared Neighborhood Hits	108
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
NC score	0.393907 (rank : 16)	θ value	0.00020696 (rank : 77)
Query Neighborhood Hits	217	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

RP3A_MOUSE
NC score	0.386875 (rank : 17)	θ value	1.09739e-05 (rank : 55)
Query Neighborhood Hits	217	Target Neighborhood Hits	510	Shared Neighborhood Hits	111
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT7_HUMAN
NC score	0.386501 (rank : 18)	θ value	5.44631e-05 (rank : 68)
Query Neighborhood Hits	217	Target Neighborhood Hits	137	Shared Neighborhood Hits	106
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
NC score	0.386282 (rank : 19)	θ value	5.44631e-05 (rank : 69)
Query Neighborhood Hits	217	Target Neighborhood Hits	137	Shared Neighborhood Hits	108
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT6_MOUSE
NC score	0.385823 (rank : 20)	θ value	2.88788e-06 (rank : 46)
Query Neighborhood Hits	217	Target Neighborhood Hits	132	Shared Neighborhood Hits	106
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT10_HUMAN
NC score	0.385019 (rank : 21)	θ value	1.09739e-05 (rank : 56)
Query Neighborhood Hits	217	Target Neighborhood Hits	134	Shared Neighborhood Hits	107
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

RP3A_HUMAN
NC score	0.384980 (rank : 22)	θ value	5.44631e-05 (rank : 67)
Query Neighborhood Hits	217	Target Neighborhood Hits	305	Shared Neighborhood Hits	111
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT6_HUMAN
NC score	0.384350 (rank : 23)	θ value	4.92598e-06 (rank : 49)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	106
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT10_MOUSE
NC score	0.383932 (rank : 24)	θ value	1.09739e-05 (rank : 57)
Query Neighborhood Hits	217	Target Neighborhood Hits	133	Shared Neighborhood Hits	106
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT9_MOUSE
NC score	0.380040 (rank : 25)	θ value	7.1131e-05 (rank : 71)
Query Neighborhood Hits	217	Target Neighborhood Hits	148	Shared Neighborhood Hits	108
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

RASF1_MOUSE
NC score	0.377681 (rank : 26)	θ value	9.92553e-07 (rank : 41)
Query Neighborhood Hits	217	Target Neighborhood Hits	74	Shared Neighborhood Hits	60
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

SYT9_HUMAN
NC score	0.377487 (rank : 27)	θ value	0.000121331 (rank : 75)
Query Neighborhood Hits	217	Target Neighborhood Hits	144	Shared Neighborhood Hits	107
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT3_HUMAN
NC score	0.371504 (rank : 28)	θ value	0.00390308 (rank : 101)
Query Neighborhood Hits	217	Target Neighborhood Hits	145	Shared Neighborhood Hits	105
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT1_HUMAN
NC score	0.371004 (rank : 29)	θ value	0.00102713 (rank : 87)
Query Neighborhood Hits	217	Target Neighborhood Hits	150	Shared Neighborhood Hits	110
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.371001 (rank : 30)	θ value	0.00102713 (rank : 88)
Query Neighborhood Hits	217	Target Neighborhood Hits	150	Shared Neighborhood Hits	110
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT3_MOUSE
NC score	0.370908 (rank : 31)	θ value	0.00390308 (rank : 102)
Query Neighborhood Hits	217	Target Neighborhood Hits	147	Shared Neighborhood Hits	105
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT5_HUMAN
NC score	0.366748 (rank : 32)	θ value	0.00298849 (rank : 94)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	108
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

RFIP2_HUMAN
NC score	0.363247 (rank : 33)	θ value	6.43352e-06 (rank : 51)
Query Neighborhood Hits	217	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

SYT2_MOUSE
NC score	0.362894 (rank : 34)	θ value	0.00665767 (rank : 109)
Query Neighborhood Hits	217	Target Neighborhood Hits	143	Shared Neighborhood Hits	108
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_MOUSE
NC score	0.362660 (rank : 35)	θ value	0.00298849 (rank : 95)
Query Neighborhood Hits	217	Target Neighborhood Hits	140	Shared Neighborhood Hits	108
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT2_HUMAN
NC score	0.361545 (rank : 36)	θ value	0.00869519 (rank : 113)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	108
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

DOC2G_MOUSE
NC score	0.347769 (rank : 37)	θ value	0.813845 (rank : 162)
Query Neighborhood Hits	217	Target Neighborhood Hits	125	Shared Neighborhood Hits	92
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

PA24D_MOUSE
NC score	0.332074 (rank : 38)	θ value	1.43324e-05 (rank : 59)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	87
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RASF1_HUMAN
NC score	0.322810 (rank : 39)	θ value	0.000121331 (rank : 74)
Query Neighborhood Hits	217	Target Neighborhood Hits	62	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RIMS2_HUMAN
NC score	0.322087 (rank : 40)	θ value	2.88788e-06 (rank : 44)
Query Neighborhood Hits	217	Target Neighborhood Hits	342	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

CHIO_MOUSE
NC score	0.321997 (rank : 41)	θ value	5.26297e-08 (rank : 26)
Query Neighborhood Hits	217	Target Neighborhood Hits	130	Shared Neighborhood Hits	72
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RIMS2_MOUSE
NC score	0.318675 (rank : 42)	θ value	2.88788e-06 (rank : 45)
Query Neighborhood Hits	217	Target Neighborhood Hits	376	Shared Neighborhood Hits	96
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

PA24B_MOUSE
NC score	0.318190 (rank : 43)	θ value	2.21117e-06 (rank : 42)
Query Neighborhood Hits	217	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

NED4L_HUMAN
NC score	0.316551 (rank : 44)	θ value	8.11959e-09 (rank : 20)
Query Neighborhood Hits	217	Target Neighborhood Hits	238	Shared Neighborhood Hits	112
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SYT4_MOUSE
NC score	0.316241 (rank : 45)	θ value	1.38821 (rank : 171)
Query Neighborhood Hits	217	Target Neighborhood Hits	123	Shared Neighborhood Hits	93
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

NED4L_MOUSE
NC score	0.315169 (rank : 46)	θ value	8.11959e-09 (rank : 21)
Query Neighborhood Hits	217	Target Neighborhood Hits	231	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

CHIO_HUMAN
NC score	0.311995 (rank : 47)	θ value	4.0297e-08 (rank : 24)
Query Neighborhood Hits	217	Target Neighborhood Hits	220	Shared Neighborhood Hits	73
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SYT11_MOUSE
NC score	0.310319 (rank : 48)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	217	Target Neighborhood Hits	116	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT4_HUMAN
NC score	0.310213 (rank : 49)	θ value	1.81305 (rank : 176)
Query Neighborhood Hits	217	Target Neighborhood Hits	121	Shared Neighborhood Hits	92
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

PA24D_HUMAN
NC score	0.310197 (rank : 50)	θ value	3.19293e-05 (rank : 64)
Query Neighborhood Hits	217	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

SYT11_HUMAN
NC score	0.308697 (rank : 51)	θ value	0.813845 (rank : 167)
Query Neighborhood Hits	217	Target Neighborhood Hits	113	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

CHIN_MOUSE
NC score	0.307992 (rank : 52)	θ value	5.26297e-08 (rank : 25)
Query Neighborhood Hits	217	Target Neighborhood Hits	229	Shared Neighborhood Hits	73
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
NC score	0.307417 (rank : 53)	θ value	6.87365e-08 (rank : 28)
Query Neighborhood Hits	217	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RIMS1_HUMAN
NC score	0.301013 (rank : 54)	θ value	1.09739e-05 (rank : 54)
Query Neighborhood Hits	217	Target Neighborhood Hits	437	Shared Neighborhood Hits	84
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

NEDD4_HUMAN
NC score	0.298702 (rank : 55)	θ value	2.13673e-09 (rank : 17)
Query Neighborhood Hits	217	Target Neighborhood Hits	214	Shared Neighborhood Hits	106
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

DGKQ_HUMAN
NC score	0.295984 (rank : 56)	θ value	0.000121331 (rank : 73)
Query Neighborhood Hits	217	Target Neighborhood Hits	131	Shared Neighborhood Hits	71
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

NEDD4_MOUSE
NC score	0.293193 (rank : 57)	θ value	1.38499e-08 (rank : 22)
Query Neighborhood Hits	217	Target Neighborhood Hits	212	Shared Neighborhood Hits	106
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PCLO_HUMAN
NC score	0.293187 (rank : 58)	θ value	4.92598e-06 (rank : 48)
Query Neighborhood Hits	217	Target Neighborhood Hits	2046	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYTL2_MOUSE
NC score	0.291974 (rank : 59)	θ value	0.0431538 (rank : 136)
Query Neighborhood Hits	217	Target Neighborhood Hits	253	Shared Neighborhood Hits	94
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_HUMAN
NC score	0.291828 (rank : 60)	θ value	0.0961366 (rank : 144)
Query Neighborhood Hits	217	Target Neighborhood Hits	248	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

MYOF_HUMAN
NC score	0.289886 (rank : 61)	θ value	0.00390308 (rank : 100)
Query Neighborhood Hits	217	Target Neighborhood Hits	147	Shared Neighborhood Hits	104
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

SYT15_HUMAN
NC score	0.286146 (rank : 62)	θ value	0.0252991 (rank : 128)
Query Neighborhood Hits	217	Target Neighborhood Hits	112	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

PA24B_HUMAN
NC score	0.279046 (rank : 63)	θ value	1.43324e-05 (rank : 58)
Query Neighborhood Hits	217	Target Neighborhood Hits	89	Shared Neighborhood Hits	72
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

DYSF_HUMAN
NC score	0.277489 (rank : 64)	θ value	0.00298849 (rank : 93)
Query Neighborhood Hits	217	Target Neighborhood Hits	170	Shared Neighborhood Hits	112
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

PDZD8_HUMAN
NC score	0.277327 (rank : 65)	θ value	0.0961366 (rank : 142)
Query Neighborhood Hits	217	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

KPCG_MOUSE
NC score	0.274916 (rank : 66)	θ value	4.02038e-16 (rank : 7)
Query Neighborhood Hits	217	Target Neighborhood Hits	1123	Shared Neighborhood Hits	172
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
NC score	0.274139 (rank : 67)	θ value	2.60593e-15 (rank : 8)
Query Neighborhood Hits	217	Target Neighborhood Hits	1126	Shared Neighborhood Hits	173
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

DYSF_MOUSE
NC score	0.273112 (rank : 68)	θ value	0.0113563 (rank : 114)
Query Neighborhood Hits	217	Target Neighborhood Hits	162	Shared Neighborhood Hits	106
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

SYTL1_HUMAN
NC score	0.270647 (rank : 69)	θ value	1.81305 (rank : 177)
Query Neighborhood Hits	217	Target Neighborhood Hits	227	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

PCLO_MOUSE
NC score	0.269595 (rank : 70)	θ value	7.1131e-05 (rank : 70)
Query Neighborhood Hits	217	Target Neighborhood Hits	2275	Shared Neighborhood Hits	125
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

KPCB_MOUSE
NC score	0.267408 (rank : 71)	θ value	4.91457e-14 (rank : 11)
Query Neighborhood Hits	217	Target Neighborhood Hits	1117	Shared Neighborhood Hits	170
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_HUMAN
NC score	0.266678 (rank : 72)	θ value	3.76295e-14 (rank : 10)
Query Neighborhood Hits	217	Target Neighborhood Hits	1121	Shared Neighborhood Hits	170
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCA_HUMAN
NC score	0.265198 (rank : 73)	θ value	6.41864e-14 (rank : 12)
Query Neighborhood Hits	217	Target Neighborhood Hits	1070	Shared Neighborhood Hits	175
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

OTOF_HUMAN
NC score	0.263855 (rank : 74)	θ value	0.813845 (rank : 164)
Query Neighborhood Hits	217	Target Neighborhood Hits	168	Shared Neighborhood Hits	100
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

KPCA_MOUSE
NC score	0.263562 (rank : 75)	θ value	1.29331e-14 (rank : 9)
Query Neighborhood Hits	217	Target Neighborhood Hits	1067	Shared Neighborhood Hits	175
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

OTOF_MOUSE
NC score	0.262922 (rank : 76)	θ value	0.813845 (rank : 165)
Query Neighborhood Hits	217	Target Neighborhood Hits	196	Shared Neighborhood Hits	99
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

RASA3_HUMAN
NC score	0.262340 (rank : 77)	θ value	0.000461057 (rank : 83)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	76
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SYT15_MOUSE
NC score	0.261360 (rank : 78)	θ value	0.0961366 (rank : 143)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	75
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

STAC_MOUSE
NC score	0.255303 (rank : 79)	θ value	0.00509761 (rank : 106)
Query Neighborhood Hits	217	Target Neighborhood Hits	268	Shared Neighborhood Hits	71
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SYTL4_HUMAN
NC score	0.253593 (rank : 80)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	77
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

RASA2_MOUSE
NC score	0.253104 (rank : 81)	θ value	0.0193708 (rank : 124)
Query Neighborhood Hits	217	Target Neighborhood Hits	159	Shared Neighborhood Hits	80
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

DGKD_HUMAN
NC score	0.252335 (rank : 82)	θ value	0.00390308 (rank : 99)
Query Neighborhood Hits	217	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

SYTL4_MOUSE
NC score	0.252286 (rank : 83)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	217	Target Neighborhood Hits	137	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

RASA2_HUMAN
NC score	0.252035 (rank : 84)	θ value	0.0148317 (rank : 119)
Query Neighborhood Hits	217	Target Neighborhood Hits	157	Shared Neighborhood Hits	77
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SYTL5_MOUSE
NC score	0.251722 (rank : 85)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	217	Target Neighborhood Hits	154	Shared Neighborhood Hits	96
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYT12_MOUSE
NC score	0.251498 (rank : 86)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	217	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYTL5_HUMAN
NC score	0.250400 (rank : 87)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	217	Target Neighborhood Hits	237	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

DGKH_HUMAN
NC score	0.247186 (rank : 88)	θ value	0.0148317 (rank : 117)
Query Neighborhood Hits	217	Target Neighborhood Hits	255	Shared Neighborhood Hits	74
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

SYT12_HUMAN
NC score	0.246618 (rank : 89)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

STAC_HUMAN
NC score	0.246599 (rank : 90)	θ value	0.00869519 (rank : 112)
Query Neighborhood Hits	217	Target Neighborhood Hits	276	Shared Neighborhood Hits	70
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CPNE2_MOUSE
NC score	0.246315 (rank : 91)	θ value	3.19293e-05 (rank : 61)
Query Neighborhood Hits	217	Target Neighborhood Hits	82	Shared Neighborhood Hits	71
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE2_HUMAN
NC score	0.246113 (rank : 92)	θ value	2.44474e-05 (rank : 60)
Query Neighborhood Hits	217	Target Neighborhood Hits	75	Shared Neighborhood Hits	70
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

SYT8_MOUSE
NC score	0.243150 (rank : 93)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	217	Target Neighborhood Hits	94	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

PA24E_MOUSE
NC score	0.242250 (rank : 94)	θ value	0.0736092 (rank : 141)
Query Neighborhood Hits	217	Target Neighborhood Hits	95	Shared Neighborhood Hits	77
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

CPNE8_HUMAN
NC score	0.241271 (rank : 95)	θ value	0.00390308 (rank : 98)
Query Neighborhood Hits	217	Target Neighborhood Hits	86	Shared Neighborhood Hits	73
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

SYTL1_MOUSE
NC score	0.239265 (rank : 96)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	217	Target Neighborhood Hits	314	Shared Neighborhood Hits	82
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

PA24F_MOUSE
NC score	0.239099 (rank : 97)	θ value	0.00102713 (rank : 86)
Query Neighborhood Hits	217	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

RASA3_MOUSE
NC score	0.237733 (rank : 98)	θ value	0.00509761 (rank : 105)
Query Neighborhood Hits	217	Target Neighborhood Hits	144	Shared Neighborhood Hits	69
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

CPNE3_HUMAN
NC score	0.237119 (rank : 99)	θ value	0.0252991 (rank : 125)
Query Neighborhood Hits	217	Target Neighborhood Hits	90	Shared Neighborhood Hits	78
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE3_MOUSE
NC score	0.236887 (rank : 100)	θ value	0.0330416 (rank : 130)
Query Neighborhood Hits	217	Target Neighborhood Hits	90	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

RFIP1_MOUSE
NC score	0.236703 (rank : 101)	θ value	9.29e-05 (rank : 72)
Query Neighborhood Hits	217	Target Neighborhood Hits	152	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

PA24E_HUMAN
NC score	0.235520 (rank : 102)	θ value	0.0563607 (rank : 139)
Query Neighborhood Hits	217	Target Neighborhood Hits	89	Shared Neighborhood Hits	76
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

CPNE8_MOUSE
NC score	0.235370 (rank : 103)	θ value	0.00869519 (rank : 111)
Query Neighborhood Hits	217	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

PA24A_MOUSE
NC score	0.234030 (rank : 104)	θ value	0.0330416 (rank : 133)
Query Neighborhood Hits	217	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

CPNE5_MOUSE
NC score	0.233948 (rank : 105)	θ value	0.0193708 (rank : 121)
Query Neighborhood Hits	217	Target Neighborhood Hits	86	Shared Neighborhood Hits	75
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_HUMAN
NC score	0.233775 (rank : 106)	θ value	0.0193708 (rank : 120)
Query Neighborhood Hits	217	Target Neighborhood Hits	88	Shared Neighborhood Hits	75
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

PA24A_HUMAN
NC score	0.228731 (rank : 107)	θ value	0.0330416 (rank : 132)
Query Neighborhood Hits	217	Target Neighborhood Hits	88	Shared Neighborhood Hits	74
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

STAC3_MOUSE
NC score	0.226934 (rank : 108)	θ value	0.279714 (rank : 152)
Query Neighborhood Hits	217	Target Neighborhood Hits	232	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SYTL3_MOUSE
NC score	0.225789 (rank : 109)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	217	Target Neighborhood Hits	110	Shared Neighborhood Hits	67
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

STAC3_HUMAN
NC score	0.223984 (rank : 110)	θ value	0.279714 (rank : 151)
Query Neighborhood Hits	217	Target Neighborhood Hits	228	Shared Neighborhood Hits	66
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

RFIP1_HUMAN
NC score	0.223045 (rank : 111)	θ value	3.19293e-05 (rank : 65)
Query Neighborhood Hits	217	Target Neighborhood Hits	236	Shared Neighborhood Hits	43
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

K0528_MOUSE
NC score	0.222700 (rank : 112)	θ value	3.0926 (rank : 182)
Query Neighborhood Hits	217	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_HUMAN
NC score	0.222677 (rank : 113)	θ value	3.0926 (rank : 181)
Query Neighborhood Hits	217	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

RASF5_MOUSE
NC score	0.220235 (rank : 114)	θ value	0.000461057 (rank : 84)
Query Neighborhood Hits	217	Target Neighborhood Hits	72	Shared Neighborhood Hits	47
SwissProt Accessions	Q5EBH1, O70407, Q6KAR0, Q8C2E8	Gene names	Rassf5, Nore1, Rapl
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

DGKB_HUMAN
NC score	0.220189 (rank : 115)	θ value	0.0193708 (rank : 122)
Query Neighborhood Hits	217	Target Neighborhood Hits	238	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKG_HUMAN
NC score	0.219940 (rank : 116)	θ value	0.0148317 (rank : 116)
Query Neighborhood Hits	217	Target Neighborhood Hits	171	Shared Neighborhood Hits	65
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

DGKG_MOUSE
NC score	0.216848 (rank : 117)	θ value	0.0193708 (rank : 123)
Query Neighborhood Hits	217	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

CPNE1_MOUSE
NC score	0.211843 (rank : 118)	θ value	0.365318 (rank : 153)
Query Neighborhood Hits	217	Target Neighborhood Hits	83	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

SYT13_HUMAN
NC score	0.198905 (rank : 119)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	217	Target Neighborhood Hits	76	Shared Neighborhood Hits	55
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

CPNE1_HUMAN
NC score	0.197888 (rank : 120)	θ value	0.279714 (rank : 149)
Query Neighborhood Hits	217	Target Neighborhood Hits	70	Shared Neighborhood Hits	66
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE7_HUMAN
NC score	0.196512 (rank : 121)	θ value	0.813845 (rank : 161)
Query Neighborhood Hits	217	Target Neighborhood Hits	92	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

RASF5_HUMAN
NC score	0.196226 (rank : 122)	θ value	0.0252991 (rank : 127)
Query Neighborhood Hits	217	Target Neighborhood Hits	79	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWW0, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99	Gene names	RASSF5, NORE1, RAPL
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

SYT13_MOUSE
NC score	0.195101 (rank : 123)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	217	Target Neighborhood Hits	69	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SMUF1_HUMAN
NC score	0.190734 (rank : 124)	θ value	0.00020696 (rank : 80)
Query Neighborhood Hits	217	Target Neighborhood Hits	135	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.189570 (rank : 125)	θ value	0.00020696 (rank : 81)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	72
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

CPNE4_HUMAN
NC score	0.188059 (rank : 126)	θ value	0.21417 (rank : 147)
Query Neighborhood Hits	217	Target Neighborhood Hits	70	Shared Neighborhood Hits	64
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
NC score	0.187655 (rank : 127)	θ value	0.21417 (rank : 148)
Query Neighborhood Hits	217	Target Neighborhood Hits	67	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CPNE6_MOUSE
NC score	0.184970 (rank : 128)	θ value	0.47712 (rank : 156)
Query Neighborhood Hits	217	Target Neighborhood Hits	87	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

KPCE_HUMAN
NC score	0.184957 (rank : 129)	θ value	1.99992e-07 (rank : 35)
Query Neighborhood Hits	217	Target Neighborhood Hits	906	Shared Neighborhood Hits	93
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
NC score	0.184698 (rank : 130)	θ value	1.99992e-07 (rank : 36)
Query Neighborhood Hits	217	Target Neighborhood Hits	906	Shared Neighborhood Hits	93
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

CPNE6_HUMAN
NC score	0.184104 (rank : 131)	θ value	0.62314 (rank : 158)
Query Neighborhood Hits	217	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

RIMS4_MOUSE
NC score	0.184031 (rank : 132)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	217	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

KPCD_MOUSE
NC score	0.183882 (rank : 133)	θ value	1.63604e-09 (rank : 16)
Query Neighborhood Hits	217	Target Neighborhood Hits	888	Shared Neighborhood Hits	78
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

PA24F_HUMAN
NC score	0.183429 (rank : 134)	θ value	1.81305 (rank : 175)
Query Neighborhood Hits	217	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

RIMS4_HUMAN
NC score	0.183212 (rank : 135)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	217	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYT14_MOUSE
NC score	0.182408 (rank : 136)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	217	Target Neighborhood Hits	82	Shared Neighborhood Hits	49
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

KPCD_HUMAN
NC score	0.182178 (rank : 137)	θ value	4.76016e-09 (rank : 18)
Query Neighborhood Hits	217	Target Neighborhood Hits	900	Shared Neighborhood Hits	78
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

SMUF2_HUMAN
NC score	0.181995 (rank : 138)	θ value	0.00228821 (rank : 92)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

CAPS2_MOUSE
NC score	0.181965 (rank : 139)	θ value	2.61198e-07 (rank : 38)
Query Neighborhood Hits	217	Target Neighborhood Hits	78	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BYR5, O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8K3K6	Gene names	Cadps2, Caps2
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

VAV2_HUMAN
NC score	0.181691 (rank : 140)	θ value	0.00175202 (rank : 89)
Query Neighborhood Hits	217	Target Neighborhood Hits	453	Shared Neighborhood Hits	65
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

KPCL_HUMAN
NC score	0.181550 (rank : 141)	θ value	8.97725e-08 (rank : 30)
Query Neighborhood Hits	217	Target Neighborhood Hits	887	Shared Neighborhood Hits	90
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_MOUSE
NC score	0.181167 (rank : 142)	θ value	6.87365e-08 (rank : 29)
Query Neighborhood Hits	217	Target Neighborhood Hits	891	Shared Neighborhood Hits	94
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCT_MOUSE
NC score	0.178612 (rank : 143)	θ value	9.59137e-10 (rank : 15)
Query Neighborhood Hits	217	Target Neighborhood Hits	895	Shared Neighborhood Hits	76
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_HUMAN
NC score	0.178150 (rank : 144)	θ value	9.59137e-10 (rank : 14)
Query Neighborhood Hits	217	Target Neighborhood Hits	897	Shared Neighborhood Hits	76
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

VAV_HUMAN
NC score	0.177161 (rank : 145)	θ value	0.00175202 (rank : 91)
Query Neighborhood Hits	217	Target Neighborhood Hits	452	Shared Neighborhood Hits	72
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_MOUSE
NC score	0.176993 (rank : 146)	θ value	0.00298849 (rank : 96)
Query Neighborhood Hits	217	Target Neighborhood Hits	456	Shared Neighborhood Hits	60
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CAPS2_HUMAN
NC score	0.176608 (rank : 147)	θ value	2.61198e-07 (rank : 37)
Query Neighborhood Hits	217	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q86UW7, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8	Gene names	CADPS2, CAPS2, KIAA1591
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

SYT14_HUMAN
NC score	0.176031 (rank : 148)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	217	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

VAV3_MOUSE
NC score	0.175058 (rank : 149)	θ value	0.00175202 (rank : 90)
Query Neighborhood Hits	217	Target Neighborhood Hits	404	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.174903 (rank : 150)	θ value	0.00390308 (rank : 103)
Query Neighborhood Hits	217	Target Neighborhood Hits	398	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV_MOUSE
NC score	0.174055 (rank : 151)	θ value	0.00298849 (rank : 97)
Query Neighborhood Hits	217	Target Neighborhood Hits	430	Shared Neighborhood Hits	68
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ITSN2_HUMAN
NC score	0.171916 (rank : 152)	θ value	0.00509761 (rank : 104)
Query Neighborhood Hits	217	Target Neighborhood Hits	1173	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

RIMS3_HUMAN
NC score	0.170938 (rank : 153)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	217	Target Neighborhood Hits	66	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

P3C2B_HUMAN
NC score	0.166558 (rank : 154)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	217	Target Neighborhood Hits	148	Shared Neighborhood Hits	66
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

RIMS3_MOUSE
NC score	0.165226 (rank : 155)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	217	Target Neighborhood Hits	67	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

KPCZ_HUMAN
NC score	0.164317 (rank : 156)	θ value	5.44631e-05 (rank : 66)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	76
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

DGKA_HUMAN
NC score	0.162859 (rank : 157)	θ value	1.06291 (rank : 169)
Query Neighborhood Hits	217	Target Neighborhood Hits	151	Shared Neighborhood Hits	57
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

KPCZ_MOUSE
NC score	0.162476 (rank : 158)	θ value	0.00020696 (rank : 79)
Query Neighborhood Hits	217	Target Neighborhood Hits	882	Shared Neighborhood Hits	75
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCI_HUMAN
NC score	0.159613 (rank : 159)	θ value	3.19293e-05 (rank : 62)
Query Neighborhood Hits	217	Target Neighborhood Hits	885	Shared Neighborhood Hits	74
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
NC score	0.159524 (rank : 160)	θ value	3.19293e-05 (rank : 63)
Query Neighborhood Hits	217	Target Neighborhood Hits	888	Shared Neighborhood Hits	76
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

ITSN2_MOUSE
NC score	0.158999 (rank : 161)	θ value	0.0148317 (rank : 118)
Query Neighborhood Hits	217	Target Neighborhood Hits	1371	Shared Neighborhood Hits	120
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

KPCD3_HUMAN
NC score	0.153715 (rank : 162)	θ value	8.11959e-09 (rank : 19)
Query Neighborhood Hits	217	Target Neighborhood Hits	895	Shared Neighborhood Hits	76
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
NC score	0.148575 (rank : 163)	θ value	5.26297e-08 (rank : 27)
Query Neighborhood Hits	217	Target Neighborhood Hits	901	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

P3C2A_HUMAN
NC score	0.147602 (rank : 164)	θ value	0.279714 (rank : 150)
Query Neighborhood Hits	217	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PERF_HUMAN
NC score	0.147600 (rank : 165)	θ value	0.0252991 (rank : 126)
Query Neighborhood Hits	217	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

MRCKA_HUMAN
NC score	0.147365 (rank : 166)	θ value	2.88788e-06 (rank : 43)
Query Neighborhood Hits	217	Target Neighborhood Hits	1999	Shared Neighborhood Hits	90
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MRCKG_MOUSE
NC score	0.145618 (rank : 167)	θ value	0.000461057 (rank : 82)
Query Neighborhood Hits	217	Target Neighborhood Hits	1466	Shared Neighborhood Hits	78
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

KPCD2_HUMAN
NC score	0.145520 (rank : 168)	θ value	3.08544e-08 (rank : 23)
Query Neighborhood Hits	217	Target Neighborhood Hits	910	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCD1_HUMAN
NC score	0.144485 (rank : 169)	θ value	1.99992e-07 (rank : 34)
Query Neighborhood Hits	217	Target Neighborhood Hits	901	Shared Neighborhood Hits	76
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MRCKB_MOUSE
NC score	0.144329 (rank : 170)	θ value	1.09739e-05 (rank : 53)
Query Neighborhood Hits	217	Target Neighborhood Hits	2180	Shared Neighborhood Hits	89
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

KPCD1_MOUSE
NC score	0.144006 (rank : 171)	θ value	2.61198e-07 (rank : 39)
Query Neighborhood Hits	217	Target Neighborhood Hits	891	Shared Neighborhood Hits	76
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

P3C2A_MOUSE
NC score	0.143872 (rank : 172)	θ value	0.813845 (rank : 166)
Query Neighborhood Hits	217	Target Neighborhood Hits	181	Shared Neighborhood Hits	61
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

MRCKG_HUMAN
NC score	0.142962 (rank : 173)	θ value	0.00102713 (rank : 85)
Query Neighborhood Hits	217	Target Neighborhood Hits	1519	Shared Neighborhood Hits	76
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKB_HUMAN
NC score	0.142791 (rank : 174)	θ value	6.43352e-06 (rank : 50)
Query Neighborhood Hits	217	Target Neighborhood Hits	2239	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PERF_MOUSE
NC score	0.139070 (rank : 175)	θ value	0.0431538 (rank : 135)
Query Neighborhood Hits	217	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

ITSN1_MOUSE
NC score	0.131546 (rank : 176)	θ value	0.163984 (rank : 146)
Query Neighborhood Hits	217	Target Neighborhood Hits	1669	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.131443 (rank : 177)	θ value	0.163984 (rank : 145)
Query Neighborhood Hits	217	Target Neighborhood Hits	1757	Shared Neighborhood Hits	127
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHG2_HUMAN
NC score	0.131411 (rank : 178)	θ value	0.00869519 (rank : 110)
Query Neighborhood Hits	217	Target Neighborhood Hits	142	Shared Neighborhood Hits	42
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

CAPS1_MOUSE
NC score	0.128551 (rank : 179)	θ value	0.0563607 (rank : 138)
Query Neighborhood Hits	217	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q80TJ1, Q3TSP2, Q61374, Q6AXB4, Q6PGF0	Gene names	Cadps, Caps, Caps1, Kiaa1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

CAPS1_HUMAN
NC score	0.127747 (rank : 180)	θ value	0.0563607 (rank : 137)
Query Neighborhood Hits	217	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULU8, Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2	Gene names	CADPS, CAPS, CAPS1, KIAA1121
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1).

RPKL1_HUMAN
NC score	0.123075 (rank : 181)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	217	Target Neighborhood Hits	708	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
NC score	0.122837 (rank : 182)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	217	Target Neighborhood Hits	704	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

DMPK_MOUSE
NC score	0.118349 (rank : 183)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	217	Target Neighborhood Hits	908	Shared Neighborhood Hits	41
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_HUMAN
NC score	0.117975 (rank : 184)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	40
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

KS6C1_MOUSE
NC score	0.117592 (rank : 185)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	217	Target Neighborhood Hits	700	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

ARHG2_MOUSE
NC score	0.116070 (rank : 186)	θ value	0.0330416 (rank : 129)
Query Neighborhood Hits	217	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

GMIP_MOUSE
NC score	0.115324 (rank : 187)	θ value	0.47712 (rank : 157)
Query Neighborhood Hits	217	Target Neighborhood Hits	202	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

KS6C1_HUMAN
NC score	0.114681 (rank : 188)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	217	Target Neighborhood Hits	682	Shared Neighborhood Hits	38
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

PKN3_HUMAN
NC score	0.114613 (rank : 189)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	217	Target Neighborhood Hits	893	Shared Neighborhood Hits	42
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN1_MOUSE
NC score	0.114591 (rank : 190)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	217	Target Neighborhood Hits	888	Shared Neighborhood Hits	40
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN1_HUMAN
NC score	0.114513 (rank : 191)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	40
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN2_HUMAN
NC score	0.113515 (rank : 192)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	217	Target Neighborhood Hits	892	Shared Neighborhood Hits	39
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
NC score	0.113312 (rank : 193)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

CTRO_HUMAN
NC score	0.113186 (rank : 194)	θ value	0.00665767 (rank : 107)
Query Neighborhood Hits	217	Target Neighborhood Hits	2092	Shared Neighborhood Hits	67
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

PKN3_MOUSE
NC score	0.112813 (rank : 195)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	217	Target Neighborhood Hits	1009	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

AKT1_HUMAN
NC score	0.112637 (rank : 196)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	217	Target Neighborhood Hits	885	Shared Neighborhood Hits	42
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

SGK2_HUMAN
NC score	0.112599 (rank : 197)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

AKT1_MOUSE
NC score	0.112599 (rank : 198)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	217	Target Neighborhood Hits	878	Shared Neighborhood Hits	41
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

DGKA_MOUSE
NC score	0.112218 (rank : 199)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	217	Target Neighborhood Hits	146	Shared Neighborhood Hits	46
SwissProt Accessions	O88673, Q922X2	Gene names	Dgka, Dagk1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

LATS1_MOUSE
NC score	0.111871 (rank : 200)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	217	Target Neighborhood Hits	1027	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

SGK3_HUMAN
NC score	0.111810 (rank : 201)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	217	Target Neighborhood Hits	877	Shared Neighborhood Hits	42
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK2_MOUSE
NC score	0.111784 (rank : 202)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

LATS1_HUMAN
NC score	0.111760 (rank : 203)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	217	Target Neighborhood Hits	1057	Shared Neighborhood Hits	44
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

SGK3_MOUSE
NC score	0.111498 (rank : 204)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	217	Target Neighborhood Hits	882	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

LATS2_MOUSE
NC score	0.111480 (rank : 205)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	217	Target Neighborhood Hits	879	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

SGK1_MOUSE
NC score	0.111404 (rank : 206)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

GMIP_HUMAN
NC score	0.111207 (rank : 207)	θ value	0.813845 (rank : 163)
Query Neighborhood Hits	217	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

SGK1_HUMAN
NC score	0.111158 (rank : 208)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	39
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

AKT2_MOUSE
NC score	0.110792 (rank : 209)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	217	Target Neighborhood Hits	875	Shared Neighborhood Hits	40
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_HUMAN
NC score	0.110769 (rank : 210)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	217	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_MOUSE
NC score	0.110758 (rank : 211)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AKT3_HUMAN
NC score	0.110724 (rank : 212)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

LATS2_HUMAN
NC score	0.110530 (rank : 213)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

ST38L_MOUSE
NC score	0.110359 (rank : 214)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

DGKK_HUMAN
NC score	0.109900 (rank : 215)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	217	Target Neighborhood Hits	378	Shared Neighborhood Hits	42
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

ST38L_HUMAN
NC score	0.109479 (rank : 216)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK38_HUMAN
NC score	0.109300 (rank : 217)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
NC score	0.109185 (rank : 218)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

CTRO_MOUSE
NC score	0.108896 (rank : 219)	θ value	0.00665767 (rank : 108)
Query Neighborhood Hits	217	Target Neighborhood Hits	2344	Shared Neighborhood Hits	71
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ARBK1_HUMAN
NC score	0.108887 (rank : 220)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	217	Target Neighborhood Hits	859	Shared Neighborhood Hits	41
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
NC score	0.108561 (rank : 221)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	41
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

GRK4_MOUSE
NC score	0.108273 (rank : 222)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	217	Target Neighborhood Hits	808	Shared Neighborhood Hits	38
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK4_HUMAN
NC score	0.107919 (rank : 223)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	217	Target Neighborhood Hits	822	Shared Neighborhood Hits	38
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

ARBK2_HUMAN
NC score	0.107713 (rank : 224)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

RK_HUMAN
NC score	0.107021 (rank : 225)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

GRK7_HUMAN
NC score	0.107015 (rank : 226)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

KS6A5_MOUSE
NC score	0.106883 (rank : 227)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

GRK5_HUMAN
NC score	0.106334 (rank : 228)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	217	Target Neighborhood Hits	819	Shared Neighborhood Hits	39
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
NC score	0.106231 (rank : 229)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	217	Target Neighborhood Hits	823	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KS6B2_MOUSE
NC score	0.106121 (rank : 230)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	217	Target Neighborhood Hits	871	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KS6B1_MOUSE
NC score	0.105483 (rank : 231)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.105473 (rank : 232)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	39
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B2_HUMAN
NC score	0.105364 (rank : 233)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KS6A4_HUMAN
NC score	0.105194 (rank : 234)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	217	Target Neighborhood Hits	868	Shared Neighborhood Hits	39
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KAPCB_MOUSE
NC score	0.105141 (rank : 235)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KS6A4_MOUSE
NC score	0.105046 (rank : 236)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	217	Target Neighborhood Hits	866	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

GRK6_MOUSE
NC score	0.104973 (rank : 237)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	39
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KAPCB_HUMAN
NC score	0.104952 (rank : 238)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCA_MOUSE
NC score	0.104478 (rank : 239)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

MAST1_HUMAN
NC score	0.104346 (rank : 240)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	217	Target Neighborhood Hits	1146	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KAPCA_HUMAN
NC score	0.104242 (rank : 241)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

GRK6_HUMAN
NC score	0.104123 (rank : 242)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	217	Target Neighborhood Hits	823	Shared Neighborhood Hits	39
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MAST1_MOUSE
NC score	0.104103 (rank : 243)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	217	Target Neighborhood Hits	1123	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

RGNEF_MOUSE
NC score	0.104074 (rank : 244)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	217	Target Neighborhood Hits	641	Shared Neighborhood Hits	76
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RK_MOUSE
NC score	0.103557 (rank : 245)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MAST3_HUMAN
NC score	0.103494 (rank : 246)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	217	Target Neighborhood Hits	1128	Shared Neighborhood Hits	43
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

KS6A5_HUMAN
NC score	0.103017 (rank : 247)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	217	Target Neighborhood Hits	855	Shared Neighborhood Hits	39
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

MAST4_HUMAN
NC score	0.102739 (rank : 248)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	217	Target Neighborhood Hits	1804	Shared Neighborhood Hits	58
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ROCK2_MOUSE
NC score	0.102718 (rank : 249)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	217	Target Neighborhood Hits	2072	Shared Neighborhood Hits	65
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

ROCK2_HUMAN
NC score	0.102592 (rank : 250)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	217	Target Neighborhood Hits	2073	Shared Neighborhood Hits	63
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

MAST2_HUMAN
NC score	0.101587 (rank : 251)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	217	Target Neighborhood Hits	1189	Shared Neighborhood Hits	44
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
NC score	0.101455 (rank : 252)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	217	Target Neighborhood Hits	1110	Shared Neighborhood Hits	42
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

KAPCG_HUMAN
NC score	0.101222 (rank : 253)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	217	Target Neighborhood Hits	845	Shared Neighborhood Hits	39
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

ST32C_HUMAN
NC score	0.101152 (rank : 254)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

PRKX_MOUSE
NC score	0.101116 (rank : 255)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKX_HUMAN
NC score	0.100998 (rank : 256)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

KGP1A_HUMAN
NC score	0.100747 (rank : 257)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	217	Target Neighborhood Hits	901	Shared Neighborhood Hits	39
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

ST32C_MOUSE
NC score	0.100726 (rank : 258)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

KGP1B_MOUSE
NC score	0.100667 (rank : 259)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	217	Target Neighborhood Hits	922	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.100653 (rank : 260)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	217	Target Neighborhood Hits	921	Shared Neighborhood Hits	39
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

MASTL_HUMAN
NC score	0.100578 (rank : 261)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	217	Target Neighborhood Hits	894	Shared Neighborhood Hits	39
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
NC score	0.100183 (rank : 262)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	217	Target Neighborhood Hits	862	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

ROCK1_HUMAN
NC score	0.099517 (rank : 263)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	217	Target Neighborhood Hits	2000	Shared Neighborhood Hits	65
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ABR_HUMAN
NC score	0.099451 (rank : 264)	θ value	0.0736092 (rank : 140)
Query Neighborhood Hits	217	Target Neighborhood Hits	166	Shared Neighborhood Hits	31
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ST32B_HUMAN
NC score	0.099400 (rank : 265)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

PA24C_HUMAN
NC score	0.099099 (rank : 266)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	217	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UP65, O75457, Q9UG68	Gene names	PLA2G4C
Domain Architecture
Description	Cytosolic phospholipase A2 gamma precursor (EC 3.1.1.4) (cPLA2-gamma) (Phospholipase A2 group IVC).

ST32B_MOUSE
NC score	0.098765 (rank : 267)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32A_HUMAN
NC score	0.098028 (rank : 268)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

KGP2_MOUSE
NC score	0.097987 (rank : 269)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	217	Target Neighborhood Hits	1029	Shared Neighborhood Hits	43
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_HUMAN
NC score	0.097702 (rank : 270)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	217	Target Neighborhood Hits	1023	Shared Neighborhood Hits	44
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

ROCK1_MOUSE
NC score	0.097625 (rank : 271)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	217	Target Neighborhood Hits	2126	Shared Neighborhood Hits	66
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RGS3_HUMAN
NC score	0.096882 (rank : 272)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	217	Target Neighborhood Hits	1375	Shared Neighborhood Hits	73
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ST32A_MOUSE
NC score	0.096749 (rank : 273)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

KS6A6_HUMAN
NC score	0.096613 (rank : 274)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	217	Target Neighborhood Hits	853	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6A1_MOUSE
NC score	0.096559 (rank : 275)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	39
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_HUMAN
NC score	0.096330 (rank : 276)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	39
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A3_MOUSE
NC score	0.096054 (rank : 277)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.096051 (rank : 278)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	217	Target Neighborhood Hits	859	Shared Neighborhood Hits	39
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PDPK1_MOUSE
NC score	0.096017 (rank : 279)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	217	Target Neighborhood Hits	852	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PDPK1_HUMAN
NC score	0.095808 (rank : 280)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

KS6A2_HUMAN
NC score	0.095604 (rank : 281)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PRKY_HUMAN
NC score	0.095420 (rank : 282)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	39
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

KS6A2_MOUSE
NC score	0.095206 (rank : 283)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

F5006_HUMAN
NC score	0.095121 (rank : 284)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	217	Target Neighborhood Hits	794	Shared Neighborhood Hits	39
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

TAC2N_HUMAN
NC score	0.095004 (rank : 285)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	217	Target Neighborhood Hits	47	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

F5006_MOUSE
NC score	0.094843 (rank : 286)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	217	Target Neighborhood Hits	793	Shared Neighborhood Hits	39
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

MYO9B_HUMAN
NC score	0.093875 (rank : 287)	θ value	0.0431538 (rank : 134)
Query Neighborhood Hits	217	Target Neighborhood Hits	641	Shared Neighborhood Hits	70
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

STK40_MOUSE
NC score	0.093118 (rank : 288)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	217	Target Neighborhood Hits	751	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

MYO9B_MOUSE
NC score	0.093082 (rank : 289)	θ value	0.0330416 (rank : 131)
Query Neighborhood Hits	217	Target Neighborhood Hits	311	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

STK40_HUMAN
NC score	0.093025 (rank : 290)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	217	Target Neighborhood Hits	751	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

TAC2N_MOUSE
NC score	0.092708 (rank : 291)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	29
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

ITCH_HUMAN
NC score	0.092180 (rank : 292)	θ value	6.88961 (rank : 204)
Query Neighborhood Hits	217	Target Neighborhood Hits	162	Shared Neighborhood Hits	31
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

TRIB3_HUMAN
NC score	0.091939 (rank : 293)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	217	Target Neighborhood Hits	519	Shared Neighborhood Hits	32
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

RGAP1_MOUSE
NC score	0.091587 (rank : 294)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	217	Target Neighborhood Hits	185	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_HUMAN
NC score	0.091500 (rank : 295)	θ value	6.88961 (rank : 208)
Query Neighborhood Hits	217	Target Neighborhood Hits	189	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RFIP5_HUMAN
NC score	0.090161 (rank : 296)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	217	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BXF6, O94939, Q9P0M1	Gene names	RAB11FIP5, GAF1, KIAA0857, RIP11
Domain Architecture
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75).

TRIB1_HUMAN
NC score	0.090005 (rank : 297)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	217	Target Neighborhood Hits	598	Shared Neighborhood Hits	38
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

ULK4_MOUSE
NC score	0.089938 (rank : 298)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	217	Target Neighborhood Hits	793	Shared Neighborhood Hits	39
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

ITCH_MOUSE
NC score	0.089694 (rank : 299)	θ value	8.99809 (rank : 213)
Query Neighborhood Hits	217	Target Neighborhood Hits	127	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

TRIB3_MOUSE
NC score	0.089240 (rank : 300)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	217	Target Neighborhood Hits	578	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

BRAF1_HUMAN
NC score	0.089204 (rank : 301)	θ value	0.0148317 (rank : 115)
Query Neighborhood Hits	217	Target Neighborhood Hits	883	Shared Neighborhood Hits	68
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

TRIB1_MOUSE
NC score	0.088845 (rank : 302)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	217	Target Neighborhood Hits	593	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

RAF1_MOUSE
NC score	0.087188 (rank : 303)	θ value	0.365318 (rank : 155)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	66
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MKNK1_HUMAN
NC score	0.087028 (rank : 304)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	217	Target Neighborhood Hits	701	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

RAF1_HUMAN
NC score	0.086513 (rank : 305)	θ value	0.365318 (rank : 154)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	66
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

TRIB2_HUMAN
NC score	0.085700 (rank : 306)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	217	Target Neighborhood Hits	657	Shared Neighborhood Hits	39
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
NC score	0.085530 (rank : 307)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	217	Target Neighborhood Hits	653	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

ST17A_HUMAN
NC score	0.085413 (rank : 308)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

WWP1_HUMAN
NC score	0.085220 (rank : 309)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	217	Target Neighborhood Hits	262	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

MKNK1_MOUSE
NC score	0.085104 (rank : 310)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	217	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

BCR_HUMAN
NC score	0.084827 (rank : 311)	θ value	1.81305 (rank : 172)
Query Neighborhood Hits	217	Target Neighborhood Hits	204	Shared Neighborhood Hits	34
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ST17B_HUMAN
NC score	0.084702 (rank : 312)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KCC1D_HUMAN
NC score	0.084657 (rank : 313)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
NC score	0.084650 (rank : 314)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

AURKB_MOUSE
NC score	0.084509 (rank : 315)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_MOUSE
NC score	0.084466 (rank : 316)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	39
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AURKC_HUMAN
NC score	0.084449 (rank : 317)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

WWP1_MOUSE
NC score	0.084320 (rank : 318)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	217	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

NUAK2_MOUSE
NC score	0.084035 (rank : 319)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	217	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

PIM2_MOUSE
NC score	0.084003 (rank : 320)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	217	Target Neighborhood Hits	809	Shared Neighborhood Hits	39
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

RFIP5_MOUSE
NC score	0.083863 (rank : 321)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	217	Target Neighborhood Hits	126	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

ARAF_MOUSE
NC score	0.083819 (rank : 322)	θ value	0.813845 (rank : 160)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	63
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

DCAK3_HUMAN
NC score	0.083599 (rank : 323)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	217	Target Neighborhood Hits	888	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

AURKB_HUMAN
NC score	0.083569 (rank : 324)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

DCAK3_MOUSE
NC score	0.083538 (rank : 325)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	217	Target Neighborhood Hits	922	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KPSH2_HUMAN
NC score	0.083532 (rank : 326)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	217	Target Neighborhood Hits	822	Shared Neighborhood Hits	39
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

TSSK4_MOUSE
NC score	0.083398 (rank : 327)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

SBK1_HUMAN
NC score	0.083347 (rank : 328)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TSSK2_MOUSE
NC score	0.083335 (rank : 329)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	217	Target Neighborhood Hits	819	Shared Neighborhood Hits	39
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

KCC1B_HUMAN
NC score	0.083222 (rank : 330)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
NC score	0.083180 (rank : 331)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

TSSK4_HUMAN
NC score	0.083172 (rank : 332)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

HUNK_HUMAN
NC score	0.083081 (rank : 333)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	39
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

ARAF_HUMAN
NC score	0.083032 (rank : 334)	θ value	0.813845 (rank : 159)
Query Neighborhood Hits	217	Target Neighborhood Hits	924	Shared Neighborhood Hits	66
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

KCC1G_MOUSE
NC score	0.082955 (rank : 335)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC4_MOUSE
NC score	0.082887 (rank : 336)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

TSSK1_HUMAN
NC score	0.082864 (rank : 337)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

HUNK_MOUSE
NC score	0.082842 (rank : 338)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

ST17B_MOUSE
NC score	0.082750 (rank : 339)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KCC1A_HUMAN
NC score	0.082747 (rank : 340)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1G_HUMAN
NC score	0.082730 (rank : 341)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	39
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

MKNK2_MOUSE
NC score	0.082727 (rank : 342)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	217	Target Neighborhood Hits	819	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MAPK5_HUMAN
NC score	0.082687 (rank : 343)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	217	Target Neighborhood Hits	795	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
NC score	0.082658 (rank : 344)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	217	Target Neighborhood Hits	799	Shared Neighborhood Hits	39
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

KCC4_HUMAN
NC score	0.082631 (rank : 345)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

PINK1_MOUSE
NC score	0.082606 (rank : 346)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	217	Target Neighborhood Hits	726	Shared Neighborhood Hits	38
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PIM3_MOUSE
NC score	0.082543 (rank : 347)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	217	Target Neighborhood Hits	783	Shared Neighborhood Hits	39
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

MKNK2_HUMAN
NC score	0.082507 (rank : 348)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KCC1A_MOUSE
NC score	0.082471 (rank : 349)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	217	Target Neighborhood Hits	845	Shared Neighborhood Hits	39
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

PIM2_HUMAN
NC score	0.082424 (rank : 350)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	217	Target Neighborhood Hits	808	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

SBK1_MOUSE
NC score	0.082402 (rank : 351)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TSSK2_HUMAN
NC score	0.082222 (rank : 352)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	39
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

NUAK2_HUMAN
NC score	0.082172 (rank : 353)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

PLK1_MOUSE
NC score	0.082170 (rank : 354)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_HUMAN
NC score	0.082149 (rank : 355)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

AAPK2_HUMAN
NC score	0.082017 (rank : 356)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

KKCC1_MOUSE
NC score	0.082013 (rank : 357)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	217	Target Neighborhood Hits	866	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PIM3_HUMAN
NC score	0.081859 (rank : 358)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	217	Target Neighborhood Hits	789	Shared Neighborhood Hits	39
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

STK6_HUMAN
NC score	0.081804 (rank : 359)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	217	Target Neighborhood Hits	916	Shared Neighborhood Hits	43
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

NIM1_HUMAN
NC score	0.081790 (rank : 360)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

STK6_MOUSE
NC score	0.081775 (rank : 361)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	41
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

AAPK1_MOUSE
NC score	0.081660 (rank : 362)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

TRIO_HUMAN
NC score	0.081447 (rank : 363)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	217	Target Neighborhood Hits	1580	Shared Neighborhood Hits	62
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

WWP2_MOUSE
NC score	0.081363 (rank : 364)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	217	Target Neighborhood Hits	118	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

KPSH1_HUMAN
NC score	0.081294 (rank : 365)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

NIM1_MOUSE
NC score	0.081238 (rank : 366)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

AAPK1_HUMAN
NC score	0.081223 (rank : 367)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KPSH1_MOUSE
NC score	0.081194 (rank : 368)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

PLCD1_HUMAN
NC score	0.081156 (rank : 369)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	217	Target Neighborhood Hits	93	Shared Neighborhood Hits	53
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

KKCC1_HUMAN
NC score	0.081107 (rank : 370)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

DUET_HUMAN
NC score	0.080960 (rank : 371)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	217	Target Neighborhood Hits	1220	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

MELK_HUMAN
NC score	0.080886 (rank : 372)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

M3K14_HUMAN
NC score	0.080824 (rank : 373)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	217	Target Neighborhood Hits	887	Shared Neighborhood Hits	42
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

WWC1_MOUSE
NC score	0.080772 (rank : 374)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	217	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

MELK_MOUSE
NC score	0.080739 (rank : 375)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

WWP2_HUMAN
NC score	0.080665 (rank : 376)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	217	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

STK33_HUMAN
NC score	0.080271 (rank : 377)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	217	Target Neighborhood Hits	879	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

PLK4_MOUSE
NC score	0.080187 (rank : 378)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	217	Target Neighborhood Hits	879	Shared Neighborhood Hits	39
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

MARK2_MOUSE
NC score	0.080098 (rank : 379)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	217	Target Neighborhood Hits	1018	Shared Neighborhood Hits	43
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

PLK4_HUMAN
NC score	0.080071 (rank : 380)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

M3K14_MOUSE
NC score	0.080069 (rank : 381)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	217	Target Neighborhood Hits	889	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

PASK_MOUSE
NC score	0.079997 (rank : 382)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PASK_HUMAN
NC score	0.079894 (rank : 383)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

MARK2_HUMAN
NC score	0.079721 (rank : 384)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	217	Target Neighborhood Hits	1056	Shared Neighborhood Hits	43
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

NUAK1_MOUSE
NC score	0.079697 (rank : 385)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	217	Target Neighborhood Hits	881	Shared Neighborhood Hits	39
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK1_HUMAN
NC score	0.079690 (rank : 386)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

CHK2_MOUSE
NC score	0.079572 (rank : 387)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

BRSK1_HUMAN
NC score	0.079556 (rank : 388)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	217	Target Neighborhood Hits	942	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

CHK2_HUMAN
NC score	0.079534 (rank : 389)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	217	Target Neighborhood Hits	859	Shared Neighborhood Hits	39
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

PHKG1_MOUSE
NC score	0.079400 (rank : 390)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PIM1_MOUSE
NC score	0.079262 (rank : 391)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	217	Target Neighborhood Hits	787	Shared Neighborhood Hits	39
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

MARK3_HUMAN
NC score	0.079253 (rank : 392)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	217	Target Neighborhood Hits	893	Shared Neighborhood Hits	40
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

PLK2_HUMAN
NC score	0.079238 (rank : 393)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MARK4_HUMAN
NC score	0.079082 (rank : 394)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	40
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
NC score	0.079068 (rank : 395)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	217	Target Neighborhood Hits	898	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

NEK3_MOUSE
NC score	0.079035 (rank : 396)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

MYLK2_HUMAN
NC score	0.079024 (rank : 397)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	217	Target Neighborhood Hits	920	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

KKCC2_MOUSE
NC score	0.078987 (rank : 398)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	217	Target Neighborhood Hits	855	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

PLK2_MOUSE
NC score	0.078979 (rank : 399)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MARK1_MOUSE
NC score	0.078975 (rank : 400)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	217	Target Neighborhood Hits	886	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

KKCC2_HUMAN
NC score	0.078967 (rank : 401)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	217	Target Neighborhood Hits	852	Shared Neighborhood Hits	39
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

PMYT1_HUMAN
NC score	0.078950 (rank : 402)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	217	Target Neighborhood Hits	814	Shared Neighborhood Hits	39
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

RIPK5_MOUSE
NC score	0.078752 (rank : 403)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

MARK3_MOUSE
NC score	0.078743 (rank : 404)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	217	Target Neighborhood Hits	919	Shared Neighborhood Hits	40
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK1_HUMAN
NC score	0.078716 (rank : 405)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	217	Target Neighborhood Hits	887	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MAPK2_HUMAN
NC score	0.078689 (rank : 406)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	39
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK3_HUMAN
NC score	0.078510 (rank : 407)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	217	Target Neighborhood Hits	807	Shared Neighborhood Hits	39
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

RIPK5_HUMAN
NC score	0.078504 (rank : 408)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	217	Target Neighborhood Hits	864	Shared Neighborhood Hits	41
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

CAMKV_HUMAN
NC score	0.078368 (rank : 409)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	217	Target Neighborhood Hits	1084	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MAPK3_MOUSE
NC score	0.078356 (rank : 410)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	217	Target Neighborhood Hits	811	Shared Neighborhood Hits	39
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

BRSK2_HUMAN
NC score	0.078340 (rank : 411)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	217	Target Neighborhood Hits	897	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

TSSK1_MOUSE
NC score	0.078264 (rank : 412)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

DAPK2_MOUSE
NC score	0.078253 (rank : 413)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

PMYT1_MOUSE
NC score	0.078235 (rank : 414)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	217	Target Neighborhood Hits	910	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PHKG1_HUMAN
NC score	0.078221 (rank : 415)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

MAPK2_MOUSE
NC score	0.078219 (rank : 416)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	39
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

CAMKV_MOUSE
NC score	0.078181 (rank : 417)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

TSSK6_HUMAN
NC score	0.078036 (rank : 418)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

K0999_HUMAN
NC score	0.077877 (rank : 419)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
NC score	0.077862 (rank : 420)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	217	Target Neighborhood Hits	931	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

DCAK2_HUMAN
NC score	0.077775 (rank : 421)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	217	Target Neighborhood Hits	862	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

NEK3_HUMAN
NC score	0.077647 (rank : 422)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	217	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

PLK3_HUMAN
NC score	0.077630 (rank : 423)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	217	Target Neighborhood Hits	865	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PIM1_HUMAN
NC score	0.077375 (rank : 424)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	217	Target Neighborhood Hits	797	Shared Neighborhood Hits	39
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PHKG2_HUMAN
NC score	0.077284 (rank : 425)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

SN1L2_MOUSE
NC score	0.077248 (rank : 426)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

ULK3_MOUSE
NC score	0.077238 (rank : 427)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

DAPK2_HUMAN
NC score	0.077220 (rank : 428)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

K0317_MOUSE
NC score	0.077201 (rank : 429)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	217	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

SNRK_HUMAN
NC score	0.077146 (rank : 430)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	217	Target Neighborhood Hits	855	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SN1L1_HUMAN
NC score	0.077125 (rank : 431)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	217	Target Neighborhood Hits	911	Shared Neighborhood Hits	40
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

RASA1_HUMAN
NC score	0.077113 (rank : 432)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	217	Target Neighborhood Hits	258	Shared Neighborhood Hits	33
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

K0317_HUMAN
NC score	0.077091 (rank : 433)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	217	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

DCAK2_MOUSE
NC score	0.077053 (rank : 434)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

PHKG2_MOUSE
NC score	0.077033 (rank : 435)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

KCC2D_HUMAN
NC score	0.076983 (rank : 436)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KCC2G_MOUSE
NC score	0.076972 (rank : 437)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_HUMAN
NC score	0.076972 (rank : 438)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

PLK3_MOUSE
NC score	0.076961 (rank : 439)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	217	Target Neighborhood Hits	863	Shared Neighborhood Hits	39
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

TSSK6_MOUSE
NC score	0.076921 (rank : 440)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

SN1L2_HUMAN
NC score	0.076831 (rank : 441)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	217	Target Neighborhood Hits	964	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

DAPK3_HUMAN
NC score	0.076730 (rank : 442)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	217	Target Neighborhood Hits	945	Shared Neighborhood Hits	45
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KCC2A_MOUSE
NC score	0.076707 (rank : 443)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_HUMAN
NC score	0.076532 (rank : 444)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
NC score	0.076504 (rank : 445)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	217	Target Neighborhood Hits	866	Shared Neighborhood Hits	40
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

STK11_HUMAN
NC score	0.076490 (rank : 446)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	39
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

ULK2_MOUSE
NC score	0.076327 (rank : 447)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	217	Target Neighborhood Hits	943	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
NC score	0.076295 (rank : 448)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

SNRK_MOUSE
NC score	0.076006 (rank : 449)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

KCC2B_MOUSE
NC score	0.075982 (rank : 450)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

PINK1_HUMAN
NC score	0.075959 (rank : 451)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	217	Target Neighborhood Hits	741	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

STK36_HUMAN
NC score	0.075949 (rank : 452)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	217	Target Neighborhood Hits	896	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

SN1L1_MOUSE
NC score	0.075936 (rank : 453)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	217	Target Neighborhood Hits	895	Shared Neighborhood Hits	41
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

DCAK1_MOUSE
NC score	0.075886 (rank : 454)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_HUMAN
NC score	0.075849 (rank : 455)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	217	Target Neighborhood Hits	877	Shared Neighborhood Hits	39
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DAPK3_MOUSE
NC score	0.075796 (rank : 456)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

PDK1L_HUMAN
NC score	0.075716 (rank : 457)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

ULK2_HUMAN
NC score	0.075655 (rank : 458)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	217	Target Neighborhood Hits	979	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

STK36_MOUSE
NC score	0.075601 (rank : 459)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	217	Target Neighborhood Hits	877	Shared Neighborhood Hits	39
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

M3K11_HUMAN
NC score	0.075537 (rank : 460)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	217	Target Neighborhood Hits	1136	Shared Neighborhood Hits	56
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

ULK1_MOUSE
NC score	0.075508 (rank : 461)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	217	Target Neighborhood Hits	1214	Shared Neighborhood Hits	42
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

PDK1L_MOUSE
NC score	0.075471 (rank : 462)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

ULK1_HUMAN
NC score	0.075382 (rank : 463)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	217	Target Neighborhood Hits	1121	Shared Neighborhood Hits	44
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

CSKP_MOUSE
NC score	0.075087 (rank : 464)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	217	Target Neighborhood Hits	1027	Shared Neighborhood Hits	49
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

HUWE1_MOUSE
NC score	0.074652 (rank : 465)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	217	Target Neighborhood Hits	406	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

TSSK3_MOUSE
NC score	0.074615 (rank : 466)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	217	Target Neighborhood Hits	806	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

HUWE1_HUMAN
NC score	0.074487 (rank : 467)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	217	Target Neighborhood Hits	443	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

CSKP_HUMAN
NC score	0.074477 (rank : 468)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	217	Target Neighborhood Hits	1022	Shared Neighborhood Hits	47
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

PAK4_MOUSE
NC score	0.074361 (rank : 469)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	217	Target Neighborhood Hits	1098	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

NEK4_HUMAN
NC score	0.074319 (rank : 470)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	217	Target Neighborhood Hits	883	Shared Neighborhood Hits	40
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
NC score	0.074055 (rank : 471)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

PAK4_HUMAN
NC score	0.073859 (rank : 472)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	217	Target Neighborhood Hits	924	Shared Neighborhood Hits	40
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

TSSK3_HUMAN
NC score	0.073703 (rank : 473)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	217	Target Neighborhood Hits	806	Shared Neighborhood Hits	38
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TBK1_MOUSE
NC score	0.073679 (rank : 474)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	217	Target Neighborhood Hits	893	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

MP2K7_HUMAN
NC score	0.073660 (rank : 475)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

DYR1A_HUMAN
NC score	0.073533 (rank : 476)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	217	Target Neighborhood Hits	764	Shared Neighborhood Hits	39
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
NC score	0.073522 (rank : 477)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	217	Target Neighborhood Hits	762	Shared Neighborhood Hits	39
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

PAK7_HUMAN
NC score	0.073376 (rank : 478)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	217	Target Neighborhood Hits	875	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

TBK1_HUMAN
NC score	0.073193 (rank : 479)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	217	Target Neighborhood Hits	861	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

E2AK2_MOUSE
NC score	0.073161 (rank : 480)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	217	Target Neighborhood Hits	864	Shared Neighborhood Hits	39
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

IKKA_HUMAN
NC score	0.073084 (rank : 481)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	217	Target Neighborhood Hits	863	Shared Neighborhood Hits	39
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
NC score	0.072923 (rank : 482)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

DYR1B_HUMAN
NC score	0.072873 (rank : 483)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

PAK7_MOUSE
NC score	0.072818 (rank : 484)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	217	Target Neighborhood Hits	875	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

NEK11_HUMAN
NC score	0.072790 (rank : 485)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	217	Target Neighborhood Hits	1043	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK2_MOUSE
NC score	0.072676 (rank : 486)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	217	Target Neighborhood Hits	876	Shared Neighborhood Hits	39
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

CHK1_HUMAN
NC score	0.072655 (rank : 487)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

M3K6_HUMAN
NC score	0.072364 (rank : 488)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	217	Target Neighborhood Hits	889	Shared Neighborhood Hits	40
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

IKKB_MOUSE
NC score	0.072298 (rank : 489)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	217	Target Neighborhood Hits	984	Shared Neighborhood Hits	41
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

M4K3_HUMAN
NC score	0.072251 (rank : 490)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

NEK1_MOUSE
NC score	0.072192 (rank : 491)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	217	Target Neighborhood Hits	1311	Shared Neighborhood Hits	53
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

IKKB_HUMAN
NC score	0.072123 (rank : 492)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	217	Target Neighborhood Hits	980	Shared Neighborhood Hits	39
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

CHK1_MOUSE
NC score	0.072012 (rank : 493)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MP2K2_HUMAN
NC score	0.071919 (rank : 494)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

NEK11_MOUSE
NC score	0.071875 (rank : 495)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	217	Target Neighborhood Hits	875	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
NC score	0.071754 (rank : 496)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	217	Target Neighborhood Hits	1129	Shared Neighborhood Hits	48
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

MP2K1_HUMAN
NC score	0.071631 (rank : 497)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	38
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
NC score	0.071606 (rank : 498)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	38
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

PAK6_HUMAN
NC score	0.071600 (rank : 499)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	217	Target Neighborhood Hits	915	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

MP2K2_MOUSE
NC score	0.071491 (rank : 500)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

M4K2_HUMAN
NC score	0.071490 (rank : 501)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	217	Target Neighborhood Hits	850	Shared Neighborhood Hits	39
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

DYR1B_MOUSE
NC score	0.071424 (rank : 502)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	217	Target Neighborhood Hits	799	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

M4K2_MOUSE
NC score	0.071349 (rank : 503)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

NEK9_MOUSE
NC score	0.071015 (rank : 504)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	217	Target Neighborhood Hits	890	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

PAK1_MOUSE
NC score	0.070985 (rank : 505)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	217	Target Neighborhood Hits	878	Shared Neighborhood Hits	42
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

NEK2_HUMAN
NC score	0.070908 (rank : 506)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	217	Target Neighborhood Hits	908	Shared Neighborhood Hits	39
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

MP2K5_MOUSE
NC score	0.070889 (rank : 507)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PAK1_HUMAN
NC score	0.070772 (rank : 508)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	217	Target Neighborhood Hits	873	Shared Neighborhood Hits	42
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

M3K15_HUMAN
NC score	0.070752 (rank : 509)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	217	Target Neighborhood Hits	914	Shared Neighborhood Hits	39
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

PAK2_HUMAN
NC score	0.070701 (rank : 510)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	217	Target Neighborhood Hits	862	Shared Neighborhood Hits	39
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

HECD2_MOUSE
NC score	0.070587 (rank : 511)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	217	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

NEK9_HUMAN
NC score	0.070586 (rank : 512)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	217	Target Neighborhood Hits	900	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

PAK2_MOUSE
NC score	0.070576 (rank : 513)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

M3K5_MOUSE
NC score	0.070485 (rank : 514)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

PXK_HUMAN
NC score	0.070476 (rank : 515)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	217	Target Neighborhood Hits	216	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PAK3_MOUSE
NC score	0.070469 (rank : 516)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

CDKL5_HUMAN
NC score	0.070384 (rank : 517)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	217	Target Neighborhood Hits	967	Shared Neighborhood Hits	42
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

M3K5_HUMAN
NC score	0.070383 (rank : 518)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	217	Target Neighborhood Hits	868	Shared Neighborhood Hits	39
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

UBE3C_HUMAN
NC score	0.070346 (rank : 519)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	217	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

PAK3_HUMAN
NC score	0.070318 (rank : 520)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	217	Target Neighborhood Hits	887	Shared Neighborhood Hits	40
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

MYLK_MOUSE
NC score	0.070123 (rank : 521)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	217	Target Neighborhood Hits	1489	Shared Neighborhood Hits	41
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

WNK3_HUMAN
NC score	0.070080 (rank : 522)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	217	Target Neighborhood Hits	948	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

HECD2_HUMAN
NC score	0.070064 (rank : 523)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	217	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

STK35_HUMAN
NC score	0.070009 (rank : 524)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	217	Target Neighborhood Hits	825	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

UBE3C_MOUSE
NC score	0.069889 (rank : 525)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	217	Target Neighborhood Hits	48	Shared Neighborhood Hits	9
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TTK_MOUSE
NC score	0.069862 (rank : 526)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	217	Target Neighborhood Hits	803	Shared Neighborhood Hits	39
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

KSR2_HUMAN
NC score	0.069720 (rank : 527)	θ value	1.81305 (rank : 174)
Query Neighborhood Hits	217	Target Neighborhood Hits	920	Shared Neighborhood Hits	61
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

MYLK_HUMAN
NC score	0.069707 (rank : 528)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	217	Target Neighborhood Hits	1328	Shared Neighborhood Hits	42
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

TTK_HUMAN
NC score	0.069531 (rank : 529)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	217	Target Neighborhood Hits	816	Shared Neighborhood Hits	40
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

RIPK3_MOUSE
NC score	0.069530 (rank : 530)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

M3K1_MOUSE
NC score	0.069520 (rank : 531)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	217	Target Neighborhood Hits	952	Shared Neighborhood Hits	40
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K9_HUMAN
NC score	0.069497 (rank : 532)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	217	Target Neighborhood Hits	1123	Shared Neighborhood Hits	58
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K10_HUMAN
NC score	0.069314 (rank : 533)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	217	Target Neighborhood Hits	1071	Shared Neighborhood Hits	55
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

UBE3A_HUMAN
NC score	0.069298 (rank : 534)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	217	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

DYRK2_HUMAN
NC score	0.069264 (rank : 535)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	217	Target Neighborhood Hits	799	Shared Neighborhood Hits	39
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

M3K3_HUMAN
NC score	0.069222 (rank : 536)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	217	Target Neighborhood Hits	885	Shared Neighborhood Hits	41
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
NC score	0.069221 (rank : 537)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	217	Target Neighborhood Hits	876	Shared Neighborhood Hits	39
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M4K5_MOUSE
NC score	0.069007 (rank : 538)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

M3K2_HUMAN
NC score	0.068902 (rank : 539)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

DGKE_HUMAN
NC score	0.068875 (rank : 540)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	217	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	P52429, Q9UKQ3	Gene names	DGKE, DAGK5
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

MP2K5_HUMAN
NC score	0.068802 (rank : 541)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

SPEG_HUMAN
NC score	0.068796 (rank : 542)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	217	Target Neighborhood Hits	1762	Shared Neighborhood Hits	52
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

M4K5_HUMAN
NC score	0.068791 (rank : 543)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	217	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

SCYL2_MOUSE
NC score	0.068659 (rank : 544)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	217	Target Neighborhood Hits	603	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

UBE3A_MOUSE
NC score	0.068619 (rank : 545)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	217	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

WNK1_MOUSE
NC score	0.068448 (rank : 546)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	217	Target Neighborhood Hits	1179	Shared Neighborhood Hits	46
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

STK10_HUMAN
NC score	0.068335 (rank : 547)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	217	Target Neighborhood Hits	1921	Shared Neighborhood Hits	59
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

E2AK4_MOUSE
NC score	0.068224 (rank : 548)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	217	Target Neighborhood Hits	984	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

WNK1_HUMAN
NC score	0.068216 (rank : 549)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	217	Target Neighborhood Hits	1158	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK4_HUMAN
NC score	0.068198 (rank : 550)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	217	Target Neighborhood Hits	1043	Shared Neighborhood Hits	44
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

STK25_HUMAN
NC score	0.068128 (rank : 551)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	217	Target Neighborhood Hits	853	Shared Neighborhood Hits	39
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

M4K1_HUMAN
NC score	0.068120 (rank : 552)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	217	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

TLK2_HUMAN
NC score	0.068113 (rank : 553)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	217	Target Neighborhood Hits	1044	Shared Neighborhood Hits	47
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

STK25_MOUSE
NC score	0.068101 (rank : 554)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

IKKE_HUMAN
NC score	0.068022 (rank : 555)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MP2K3_MOUSE
NC score	0.067980 (rank : 556)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	38
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MST4_MOUSE
NC score	0.067974 (rank : 557)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.067937 (rank : 558)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	217	Target Neighborhood Hits	852	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

RIPK3_HUMAN
NC score	0.067907 (rank : 559)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

HIPK2_HUMAN
NC score	0.067893 (rank : 560)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	217	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
NC score	0.067868 (rank : 561)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	217	Target Neighborhood Hits	871	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

WNK4_MOUSE
NC score	0.067861 (rank : 562)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	217	Target Neighborhood Hits	961	Shared Neighborhood Hits	42
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

NEK8_HUMAN
NC score	0.067721 (rank : 563)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

TLK2_MOUSE
NC score	0.067647 (rank : 564)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	217	Target Neighborhood Hits	1088	Shared Neighborhood Hits	50
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

NEK8_MOUSE
NC score	0.067615 (rank : 565)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

STK24_MOUSE
NC score	0.067589 (rank : 566)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	217	Target Neighborhood Hits	856	Shared Neighborhood Hits	39
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

E2AK2_HUMAN
NC score	0.067545 (rank : 567)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	217	Target Neighborhood Hits	856	Shared Neighborhood Hits	39
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

OBSCN_HUMAN
NC score	0.067483 (rank : 568)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	217	Target Neighborhood Hits	1931	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

STK24_HUMAN
NC score	0.067453 (rank : 569)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	217	Target Neighborhood Hits	853	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

M4K1_MOUSE
NC score	0.067337 (rank : 570)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	217	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

SCYL2_HUMAN
NC score	0.067322 (rank : 571)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	217	Target Neighborhood Hits	632	Shared Neighborhood Hits	37
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

TLK1_HUMAN
NC score	0.067302 (rank : 572)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	217	Target Neighborhood Hits	967	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
NC score	0.067181 (rank : 573)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	217	Target Neighborhood Hits	947	Shared Neighborhood Hits	43
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

M3K2_MOUSE
NC score	0.067143 (rank : 574)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

PXK_MOUSE
NC score	0.067079 (rank : 575)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	217	Target Neighborhood Hits	320	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

M3KL4_HUMAN
NC score	0.066936 (rank : 576)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	217	Target Neighborhood Hits	1087	Shared Neighborhood Hits	55
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

BTK_HUMAN
NC score	0.066933 (rank : 577)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	217	Target Neighborhood Hits	1026	Shared Neighborhood Hits	60
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

M3K4_HUMAN
NC score	0.066898 (rank : 578)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	217	Target Neighborhood Hits	911	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

STK10_MOUSE
NC score	0.066636 (rank : 579)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	217	Target Neighborhood Hits	2132	Shared Neighborhood Hits	60
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

SPEG_MOUSE
NC score	0.066624 (rank : 580)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	217	Target Neighborhood Hits	1959	Shared Neighborhood Hits	54
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STK39_MOUSE
NC score	0.066594 (rank : 581)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	217	Target Neighborhood Hits	915	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

M3K4_MOUSE
NC score	0.066591 (rank : 582)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	217	Target Neighborhood Hits	924	Shared Neighborhood Hits	40
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

BTK_MOUSE
NC score	0.066580 (rank : 583)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	217	Target Neighborhood Hits	1017	Shared Neighborhood Hits	60
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

E2AK4_HUMAN
NC score	0.066545 (rank : 584)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	217	Target Neighborhood Hits	1012	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

STK39_HUMAN
NC score	0.066481 (rank : 585)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	217	Target Neighborhood Hits	882	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

WNK2_HUMAN
NC score	0.066477 (rank : 586)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	217	Target Neighborhood Hits	1407	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

HIPK1_MOUSE
NC score	0.066428 (rank : 587)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HIPK1_HUMAN
NC score	0.066424 (rank : 588)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

OXSR1_MOUSE
NC score	0.066419 (rank : 589)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	217	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

NRK_MOUSE
NC score	0.066303 (rank : 590)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	217	Target Neighborhood Hits	899	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

HIPK3_MOUSE
NC score	0.066247 (rank : 591)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

BMX_HUMAN
NC score	0.066244 (rank : 592)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	217	Target Neighborhood Hits	942	Shared Neighborhood Hits	52
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SLK_MOUSE
NC score	0.066212 (rank : 593)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	217	Target Neighborhood Hits	1798	Shared Neighborhood Hits	61
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

GSK3A_HUMAN
NC score	0.066011 (rank : 594)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

SLK_HUMAN
NC score	0.065966 (rank : 595)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	217	Target Neighborhood Hits	1775	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

NEK6_HUMAN
NC score	0.065957 (rank : 596)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

OXSR1_HUMAN
NC score	0.065953 (rank : 597)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

HIPK4_HUMAN
NC score	0.065890 (rank : 598)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	217	Target Neighborhood Hits	799	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

DYRK3_HUMAN
NC score	0.065887 (rank : 599)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	217	Target Neighborhood Hits	798	Shared Neighborhood Hits	40
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

M4K4_HUMAN
NC score	0.065875 (rank : 600)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	217	Target Neighborhood Hits	1589	Shared Neighborhood Hits	55
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

PFTK1_MOUSE
NC score	0.065866 (rank : 601)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

NEK6_MOUSE
NC score	0.065797 (rank : 602)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

HIPK3_HUMAN
NC score	0.065750 (rank : 603)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

STK3_HUMAN
NC score	0.065623 (rank : 604)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	217	Target Neighborhood Hits	861	Shared Neighborhood Hits	39
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

MINK1_MOUSE
NC score	0.065575 (rank : 605)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	217	Target Neighborhood Hits	1451	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

RIPK2_MOUSE
NC score	0.065564 (rank : 606)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	217	Target Neighborhood Hits	776	Shared Neighborhood Hits	39
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

MINK1_HUMAN
NC score	0.065533 (rank : 607)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	217	Target Neighborhood Hits	1477	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

STK3_MOUSE
NC score	0.065403 (rank : 608)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	217	Target Neighborhood Hits	869	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

BMX_MOUSE
NC score	0.065358 (rank : 609)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	217	Target Neighborhood Hits	912	Shared Neighborhood Hits	50
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

PFTK1_HUMAN
NC score	0.065337 (rank : 610)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

YSK4_HUMAN
NC score	0.065292 (rank : 611)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	217	Target Neighborhood Hits	921	Shared Neighborhood Hits	43
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

GSK3B_HUMAN
NC score	0.065278 (rank : 612)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	217	Target Neighborhood Hits	801	Shared Neighborhood Hits	39
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.065278 (rank : 613)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	217	Target Neighborhood Hits	800	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

DGKE_MOUSE
NC score	0.065202 (rank : 614)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	217	Target Neighborhood Hits	30	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R1C6	Gene names	Dgke
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

CSK22_HUMAN
NC score	0.065110 (rank : 615)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	217	Target Neighborhood Hits	758	Shared Neighborhood Hits	38
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

IRAK1_MOUSE
NC score	0.065024 (rank : 616)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	217	Target Neighborhood Hits	784	Shared Neighborhood Hits	39
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

CSK22_MOUSE
NC score	0.064964 (rank : 617)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	217	Target Neighborhood Hits	758	Shared Neighborhood Hits	38
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

MP2K3_HUMAN
NC score	0.064959 (rank : 618)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	217	Target Neighborhood Hits	825	Shared Neighborhood Hits	38
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MYO3B_HUMAN
NC score	0.064933 (rank : 619)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	217	Target Neighborhood Hits	923	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

MP2K4_MOUSE
NC score	0.064907 (rank : 620)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

NEK7_MOUSE
NC score	0.064883 (rank : 621)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	217	Target Neighborhood Hits	847	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

WWC1_HUMAN
NC score	0.064808 (rank : 622)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	217	Target Neighborhood Hits	290	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

MP2K4_HUMAN
NC score	0.064806 (rank : 623)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

M3K8_MOUSE
NC score	0.064803 (rank : 624)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	217	Target Neighborhood Hits	815	Shared Neighborhood Hits	39
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

STK4_MOUSE
NC score	0.064796 (rank : 625)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	217	Target Neighborhood Hits	873	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

DAPK1_HUMAN
NC score	0.064789 (rank : 626)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	217	Target Neighborhood Hits	1130	Shared Neighborhood Hits	40
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
NC score	0.064763 (rank : 627)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	217	Target Neighborhood Hits	1138	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

STK4_HUMAN
NC score	0.064707 (rank : 628)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	217	Target Neighborhood Hits	870	Shared Neighborhood Hits	39
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

CDKL2_MOUSE
NC score	0.064690 (rank : 629)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	217	Target Neighborhood Hits	854	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

NRK_HUMAN
NC score	0.064683 (rank : 630)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	217	Target Neighborhood Hits	931	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NEK7_HUMAN
NC score	0.064637 (rank : 631)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	217	Target Neighborhood Hits	846	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

TNIK_HUMAN
NC score	0.064583 (rank : 632)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	217	Target Neighborhood Hits	1570	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

IKKE_MOUSE
NC score	0.064558 (rank : 633)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	217	Target Neighborhood Hits	848	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

STK16_HUMAN
NC score	0.064554 (rank : 634)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

M4K4_MOUSE
NC score	0.064523 (rank : 635)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	217	Target Neighborhood Hits	1560	Shared Neighborhood Hits	51
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

CSK21_MOUSE
NC score	0.064497 (rank : 636)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	217	Target Neighborhood Hits	770	Shared Neighborhood Hits	38
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

ERN2_MOUSE
NC score	0.064340 (rank : 637)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	217	Target Neighborhood Hits	825	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

TEC_HUMAN
NC score	0.064210 (rank : 638)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	217	Target Neighborhood Hits	1006	Shared Neighborhood Hits	60
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

KSR1_MOUSE
NC score	0.064100 (rank : 639)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	217	Target Neighborhood Hits	870	Shared Neighborhood Hits	54
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

WEE1B_MOUSE
NC score	0.064002 (rank : 640)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	217	Target Neighborhood Hits	765	Shared Neighborhood Hits	40
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

AL2S7_HUMAN
NC score	0.063963 (rank : 641)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	39
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

CDKL2_HUMAN
NC score	0.063878 (rank : 642)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

M3K8_HUMAN
NC score	0.063800 (rank : 643)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	217	Target Neighborhood Hits	807	Shared Neighborhood Hits	39
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

CSK21_HUMAN
NC score	0.063503 (rank : 644)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	217	Target Neighborhood Hits	772	Shared Neighborhood Hits	38
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CDC7_MOUSE
NC score	0.063475 (rank : 645)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	217	Target Neighborhood Hits	641	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

WEE1B_HUMAN
NC score	0.063377 (rank : 646)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	45
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

CDK3_MOUSE
NC score	0.063308 (rank : 647)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

PCTK1_MOUSE
NC score	0.063252 (rank : 648)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

MP2K6_HUMAN
NC score	0.063158 (rank : 649)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

PCTK1_HUMAN
NC score	0.063150 (rank : 650)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PRP4B_HUMAN
NC score	0.063147 (rank : 651)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	217	Target Neighborhood Hits	1030	Shared Neighborhood Hits	46
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

TEC_MOUSE
NC score	0.063078 (rank : 652)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	217	Target Neighborhood Hits	1006	Shared Neighborhood Hits	58
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

E2AK1_MOUSE
NC score	0.062715 (rank : 653)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

TCGAP_MOUSE
NC score	0.062679 (rank : 654)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	217	Target Neighborhood Hits	409	Shared Neighborhood Hits	29
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PCTK3_MOUSE
NC score	0.062499 (rank : 655)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDK2_HUMAN
NC score	0.062497 (rank : 656)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

LRRK1_HUMAN
NC score	0.062437 (rank : 657)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	217	Target Neighborhood Hits	1237	Shared Neighborhood Hits	38
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

PRP4B_MOUSE
NC score	0.062388 (rank : 658)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	217	Target Neighborhood Hits	1040	Shared Neighborhood Hits	47
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

MYO3A_HUMAN
NC score	0.062387 (rank : 659)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	217	Target Neighborhood Hits	1033	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

PCTK2_MOUSE
NC score	0.062336 (rank : 660)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_HUMAN
NC score	0.062330 (rank : 661)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MYO3A_MOUSE
NC score	0.062264 (rank : 662)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	217	Target Neighborhood Hits	902	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MP2K6_MOUSE
NC score	0.062257 (rank : 663)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

RIPK2_HUMAN
NC score	0.062244 (rank : 664)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	217	Target Neighborhood Hits	774	Shared Neighborhood Hits	39
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

CDC2_MOUSE
NC score	0.062106 (rank : 665)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

PCTK3_HUMAN
NC score	0.062014 (rank : 666)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	217	Target Neighborhood Hits	827	Shared Neighborhood Hits	39
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

TITIN_HUMAN
NC score	0.061981 (rank : 667)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	217	Target Neighborhood Hits	2923	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CDC2_HUMAN
NC score	0.061930 (rank : 668)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDKL3_HUMAN
NC score	0.061888 (rank : 669)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	217	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
NC score	0.061858 (rank : 670)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

M3K13_HUMAN
NC score	0.061809 (rank : 671)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	217	Target Neighborhood Hits	911	Shared Neighborhood Hits	42
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

IRAK4_MOUSE
NC score	0.061715 (rank : 672)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

KSR1_HUMAN
NC score	0.061607 (rank : 673)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

CDKL4_MOUSE
NC score	0.061556 (rank : 674)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

MLTK_MOUSE
NC score	0.061548 (rank : 675)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

HERC5_HUMAN
NC score	0.061506 (rank : 676)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	217	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

ABL1_HUMAN
NC score	0.061478 (rank : 677)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	217	Target Neighborhood Hits	1220	Shared Neighborhood Hits	64
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

MOS_HUMAN
NC score	0.061373 (rank : 678)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

CD2L1_MOUSE
NC score	0.061333 (rank : 679)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	217	Target Neighborhood Hits	1463	Shared Neighborhood Hits	56
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

MK15_MOUSE
NC score	0.061327 (rank : 680)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MLTK_HUMAN
NC score	0.061290 (rank : 681)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	217	Target Neighborhood Hits	911	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

ABL1_MOUSE
NC score	0.061062 (rank : 682)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	217	Target Neighborhood Hits	1178	Shared Neighborhood Hits	65
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CD2L2_HUMAN
NC score	0.060995 (rank : 683)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	217	Target Neighborhood Hits	1439	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CDKL4_HUMAN
NC score	0.060856 (rank : 684)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDK2_MOUSE
NC score	0.060823 (rank : 685)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	217	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

UHMK1_MOUSE
NC score	0.060811 (rank : 686)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	217	Target Neighborhood Hits	809	Shared Neighborhood Hits	39
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

CD2L1_HUMAN
NC score	0.060724 (rank : 687)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	217	Target Neighborhood Hits	1467	Shared Neighborhood Hits	55
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

UHMK1_HUMAN
NC score	0.060686 (rank : 688)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	217	Target Neighborhood Hits	808	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

CDK5_HUMAN
NC score	0.060541 (rank : 689)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	39
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
NC score	0.060539 (rank : 690)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	217	Target Neighborhood Hits	826	Shared Neighborhood Hits	39
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CCRK_MOUSE
NC score	0.060522 (rank : 691)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

DYRK4_HUMAN
NC score	0.060332 (rank : 692)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	217	Target Neighborhood Hits	750	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

TAOK2_MOUSE
NC score	0.060326 (rank : 693)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	217	Target Neighborhood Hits	1373	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

ABL2_HUMAN
NC score	0.060303 (rank : 694)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	217	Target Neighborhood Hits	1045	Shared Neighborhood Hits	57
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

CDKL1_MOUSE
NC score	0.060208 (rank : 695)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CCRK_HUMAN
NC score	0.060105 (rank : 696)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CSK_MOUSE
NC score	0.059950 (rank : 697)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	217	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

MK15_HUMAN
NC score	0.059849 (rank : 698)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	217	Target Neighborhood Hits	1038	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

IRAK1_HUMAN
NC score	0.059807 (rank : 699)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	217	Target Neighborhood Hits	820	Shared Neighborhood Hits	39
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

RHG12_MOUSE
NC score	0.059731 (rank : 700)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	217	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TESK2_HUMAN
NC score	0.059562 (rank : 701)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TAOK2_HUMAN
NC score	0.059497 (rank : 702)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	217	Target Neighborhood Hits	1172	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

LIMK1_HUMAN
NC score	0.059485 (rank : 703)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	217	Target Neighborhood Hits	1005	Shared Neighborhood Hits	39
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MAK_MOUSE
NC score	0.059472 (rank : 704)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	217	Target Neighborhood Hits	873	Shared Neighborhood Hits	40
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

CDKL1_HUMAN
NC score	0.059418 (rank : 705)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	39
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

YAP1_MOUSE
NC score	0.059345 (rank : 706)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	217	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

MAK_HUMAN
NC score	0.059293 (rank : 707)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	217	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

TRIPC_HUMAN
NC score	0.059266 (rank : 708)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	217	Target Neighborhood Hits	319	Shared Neighborhood Hits	11
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

CSK_HUMAN
NC score	0.059237 (rank : 709)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	217	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

M3K12_HUMAN
NC score	0.059041 (rank : 710)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	217	Target Neighborhood Hits	940	Shared Neighborhood Hits	41
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

TNI3K_MOUSE
NC score	0.059037 (rank : 711)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	217	Target Neighborhood Hits	1079	Shared Neighborhood Hits	40
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CDK7_MOUSE
NC score	0.058980 (rank : 712)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

M3K12_MOUSE
NC score	0.058978 (rank : 713)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	217	Target Neighborhood Hits	957	Shared Neighborhood Hits	41
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

RHG09_HUMAN
NC score	0.058956 (rank : 714)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	217	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

LRRK1_MOUSE
NC score	0.058891 (rank : 715)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	217	Target Neighborhood Hits	1267	Shared Neighborhood Hits	37
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

CDK7_HUMAN
NC score	0.058868 (rank : 716)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

ERN2_HUMAN
NC score	0.058828 (rank : 717)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	38
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

RIPK1_HUMAN
NC score	0.058816 (rank : 718)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	217	Target Neighborhood Hits	891	Shared Neighborhood Hits	40
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TAOK3_MOUSE
NC score	0.058792 (rank : 719)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	217	Target Neighborhood Hits	1458	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

LIMK1_MOUSE
NC score	0.058743 (rank : 720)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	217	Target Neighborhood Hits	1008	Shared Neighborhood Hits	39
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

E2AK1_HUMAN
NC score	0.058689 (rank : 721)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

ICK_MOUSE
NC score	0.058629 (rank : 722)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	217	Target Neighborhood Hits	860	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

TESK1_MOUSE
NC score	0.058515 (rank : 723)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	217	Target Neighborhood Hits	862	Shared Neighborhood Hits	39
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

CDK3_HUMAN
NC score	0.058428 (rank : 724)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

E2AK3_MOUSE
NC score	0.058189 (rank : 725)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

RIPK1_MOUSE
NC score	0.058188 (rank : 726)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ICK_HUMAN
NC score	0.058160 (rank : 727)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

RHG26_HUMAN
NC score	0.058137 (rank : 728)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	217	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

TESK2_MOUSE
NC score	0.058065 (rank : 729)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TNI3K_HUMAN
NC score	0.058029 (rank : 730)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	217	Target Neighborhood Hits	1084	Shared Neighborhood Hits	40
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ERN1_MOUSE
NC score	0.057976 (rank : 731)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	217	Target Neighborhood Hits	823	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

LIMK2_HUMAN
NC score	0.057908 (rank : 732)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	217	Target Neighborhood Hits	986	Shared Neighborhood Hits	39
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

HERC3_HUMAN
NC score	0.057896 (rank : 733)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	217	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

TAOK1_MOUSE
NC score	0.057873 (rank : 734)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	217	Target Neighborhood Hits	1720	Shared Neighborhood Hits	57
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

STK16_MOUSE
NC score	0.057870 (rank : 735)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	217	Target Neighborhood Hits	824	Shared Neighborhood Hits	39
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

TAOK3_HUMAN
NC score	0.057828 (rank : 736)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	217	Target Neighborhood Hits	1494	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK1_HUMAN
NC score	0.057783 (rank : 737)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	217	Target Neighborhood Hits	1734	Shared Neighborhood Hits	56
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

IRAK4_HUMAN
NC score	0.057775 (rank : 738)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	217	Target Neighborhood Hits	816	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

CDK6_MOUSE
NC score	0.057752 (rank : 739)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

LIMK2_MOUSE
NC score	0.057702 (rank : 740)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	217	Target Neighborhood Hits	998	Shared Neighborhood Hits	41
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

TESK1_HUMAN
NC score	0.057693 (rank : 741)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	217	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

FER_HUMAN
NC score	0.057621 (rank : 742)	θ value	8.99809 (rank : 211)
Query Neighborhood Hits	217	Target Neighborhood Hits	1278	Shared Neighborhood Hits	58
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

TXK_HUMAN
NC score	0.057596 (rank : 743)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	217	Target Neighborhood Hits	971	Shared Neighborhood Hits	51
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

MOS_MOUSE
NC score	0.057529 (rank : 744)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	217	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ZAP70_HUMAN
NC score	0.057312 (rank : 745)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	217	Target Neighborhood Hits	893	Shared Neighborhood Hits	47
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CD2L7_HUMAN
NC score	0.057283 (rank : 746)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	217	Target Neighborhood Hits	1275	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

MK08_MOUSE
NC score	0.057199 (rank : 747)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

CDK6_HUMAN
NC score	0.057150 (rank : 748)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

MK08_HUMAN
NC score	0.057145 (rank : 749)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

FYN_HUMAN
NC score	0.057105 (rank : 750)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	217	Target Neighborhood Hits	1078	Shared Neighborhood Hits	56
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

ITK_HUMAN
NC score	0.057048 (rank : 751)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	217	Target Neighborhood Hits	1016	Shared Neighborhood Hits	58
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

CDK10_HUMAN
NC score	0.057019 (rank : 752)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	217	Target Neighborhood Hits	831	Shared Neighborhood Hits	39
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

ITK_MOUSE
NC score	0.057010 (rank : 753)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	217	Target Neighborhood Hits	985	Shared Neighborhood Hits	57
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

RHG12_HUMAN
NC score	0.056978 (rank : 754)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	217	Target Neighborhood Hits	190	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TCGAP_HUMAN
NC score	0.056882 (rank : 755)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	217	Target Neighborhood Hits	872	Shared Neighborhood Hits	32
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ERN1_HUMAN
NC score	0.056878 (rank : 756)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	41
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

E2AK3_HUMAN
NC score	0.056820 (rank : 757)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	217	Target Neighborhood Hits	859	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

M3K7_MOUSE
NC score	0.056771 (rank : 758)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	217	Target Neighborhood Hits	892	Shared Neighborhood Hits	39
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

RASF3_MOUSE
NC score	0.056763 (rank : 759)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	217	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q99P51, Q3TJ17	Gene names	Rassf3
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 3.

M3K7_HUMAN
NC score	0.056694 (rank : 760)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	217	Target Neighborhood Hits	892	Shared Neighborhood Hits	39
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

RASF3_HUMAN
NC score	0.056659 (rank : 761)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	217	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q86WH2, Q86WH1	Gene names	RASSF3
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 3.

MK09_HUMAN
NC score	0.056605 (rank : 762)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	217	Target Neighborhood Hits	842	Shared Neighborhood Hits	39
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

PTK6_MOUSE
NC score	0.056539 (rank : 763)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	217	Target Neighborhood Hits	1026	Shared Neighborhood Hits	54
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

WEE1_HUMAN
NC score	0.056357 (rank : 764)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	217	Target Neighborhood Hits	777	Shared Neighborhood Hits	42
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

KC1AL_HUMAN
NC score	0.056322 (rank : 765)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	217	Target Neighborhood Hits	734	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

ZAP70_MOUSE
NC score	0.056231 (rank : 766)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	217	Target Neighborhood Hits	905	Shared Neighborhood Hits	47
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

DAB2P_HUMAN
NC score	0.056177 (rank : 767)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	217	Target Neighborhood Hits	303	Shared Neighborhood Hits	19
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

MK09_MOUSE
NC score	0.056116 (rank : 768)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	217	Target Neighborhood Hits	843	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

CD2L5_HUMAN
NC score	0.056103 (rank : 769)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	217	Target Neighborhood Hits	987	Shared Neighborhood Hits	41
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

KSYK_HUMAN
NC score	0.056078 (rank : 770)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	217	Target Neighborhood Hits	901	Shared Neighborhood Hits	48
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CD2L5_MOUSE
NC score	0.056057 (rank : 771)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	217	Target Neighborhood Hits	1011	Shared Neighborhood Hits	40
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

AAK1_HUMAN
NC score	0.056008 (rank : 772)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	217	Target Neighborhood Hits	1077	Shared Neighborhood Hits	46
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

FRK_HUMAN
NC score	0.055995 (rank : 773)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	217	Target Neighborhood Hits	1058	Shared Neighborhood Hits	56
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

MK10_HUMAN
NC score	0.055980 (rank : 774)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

FYN_MOUSE
NC score	0.055693 (rank : 775)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	217	Target Neighborhood Hits	1073	Shared Neighborhood Hits	56
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

PLCD1_MOUSE
NC score	0.055679 (rank : 776)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	217	Target Neighborhood Hits	106	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

KSYK_MOUSE
NC score	0.055673 (rank : 777)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	217	Target Neighborhood Hits	944	Shared Neighborhood Hits	48
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MK12_HUMAN
NC score	0.055671 (rank : 778)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	217	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK11_MOUSE
NC score	0.055635 (rank : 779)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

LYN_HUMAN
NC score	0.055621 (rank : 780)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	217	Target Neighborhood Hits	1022	Shared Neighborhood Hits	54
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TXK_MOUSE
NC score	0.055438 (rank : 781)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	217	Target Neighborhood Hits	980	Shared Neighborhood Hits	51
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LRRK2_HUMAN
NC score	0.055422 (rank : 782)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	217	Target Neighborhood Hits	1382	Shared Neighborhood Hits	39
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

BMP2K_HUMAN
NC score	0.055394 (rank : 783)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	217	Target Neighborhood Hits	867	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

MK10_MOUSE
NC score	0.055358 (rank : 784)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	217	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

RHG04_HUMAN
NC score	0.055355 (rank : 785)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	217	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

MK13_MOUSE
NC score	0.055224 (rank : 786)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	217	Target Neighborhood Hits	832	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

LYN_MOUSE
NC score	0.055220 (rank : 787)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	217	Target Neighborhood Hits	1023	Shared Neighborhood Hits	54
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

HCK_HUMAN
NC score	0.055153 (rank : 788)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	217	Target Neighborhood Hits	1035	Shared Neighborhood Hits	55
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MK14_MOUSE
NC score	0.055127 (rank : 789)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

DAB2P_MOUSE
NC score	0.055089 (rank : 790)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	217	Target Neighborhood Hits	284	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

NGAP_HUMAN
NC score	0.054998 (rank : 791)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	217	Target Neighborhood Hits	517	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

MK11_HUMAN
NC score	0.054985 (rank : 792)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	217	Target Neighborhood Hits	823	Shared Neighborhood Hits	39
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

BMP2K_MOUSE
NC score	0.054841 (rank : 793)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	217	Target Neighborhood Hits	874	Shared Neighborhood Hits	44
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CDK4_HUMAN
NC score	0.054796 (rank : 794)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	217	Target Neighborhood Hits	834	Shared Neighborhood Hits	39
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

STYK1_HUMAN
NC score	0.054702 (rank : 795)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	217	Target Neighborhood Hits	786	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

MK14_HUMAN
NC score	0.054617 (rank : 796)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

KC1G1_HUMAN
NC score	0.054608 (rank : 797)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	217	Target Neighborhood Hits	708	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

AAK1_MOUSE
NC score	0.054595 (rank : 798)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	217	Target Neighborhood Hits	1051	Shared Neighborhood Hits	42
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

JAK3_MOUSE
NC score	0.054591 (rank : 799)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	217	Target Neighborhood Hits	821	Shared Neighborhood Hits	39
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

MK13_HUMAN
NC score	0.054540 (rank : 800)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	217	Target Neighborhood Hits	829	Shared Neighborhood Hits	39
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK07_MOUSE
NC score	0.054469 (rank : 801)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	217	Target Neighborhood Hits	1054	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

WEE1_MOUSE
NC score	0.054396 (rank : 802)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	217	Target Neighborhood Hits	794	Shared Neighborhood Hits	39
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

MK07_HUMAN
NC score	0.054388 (rank : 803)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	217	Target Neighborhood Hits	1087	Shared Neighborhood Hits	43
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

CDK4_MOUSE
NC score	0.054372 (rank : 804)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	217	Target Neighborhood Hits	838	Shared Neighborhood Hits	39
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

KC1G1_MOUSE
NC score	0.054199 (rank : 805)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	217	Target Neighborhood Hits	713	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

CDC7_HUMAN
NC score	0.054040 (rank : 806)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	217	Target Neighborhood Hits	652	Shared Neighborhood Hits	35
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

HCK_MOUSE
NC score	0.053837 (rank : 807)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	217	Target Neighborhood Hits	1029	Shared Neighborhood Hits	53
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

PTK6_HUMAN
NC score	0.053814 (rank : 808)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	217	Target Neighborhood Hits	1020	Shared Neighborhood Hits	54
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

GAK_MOUSE
NC score	0.053792 (rank : 809)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	217	Target Neighborhood Hits	964	Shared Neighborhood Hits	42
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

JAK3_HUMAN
NC score	0.053784 (rank : 810)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	217	Target Neighborhood Hits	827	Shared Neighborhood Hits	39
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

MK12_MOUSE
NC score	0.053585 (rank : 811)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	217	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

SRC_HUMAN
NC score	0.053347 (rank : 812)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	217	Target Neighborhood Hits	1058	Shared Neighborhood Hits	56
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
NC score	0.053248 (rank : 813)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	217	Target Neighborhood Hits	1033	Shared Neighborhood Hits	56
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP1_HUMAN
NC score	0.053110 (rank : 814)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	217	Target Neighborhood Hits	390	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

MOK_HUMAN
NC score	0.053057 (rank : 815)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	217	Target Neighborhood Hits	807	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

KC1G2_MOUSE
NC score	0.053048 (rank : 816)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	217	Target Neighborhood Hits	695	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

FES_HUMAN
NC score	0.053043 (rank : 817)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	217	Target Neighborhood Hits	978	Shared Neighborhood Hits	42
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

NLK_HUMAN
NC score	0.052953 (rank : 818)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
NC score	0.052952 (rank : 819)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	217	Target Neighborhood Hits	839	Shared Neighborhood Hits	39
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

MATK_MOUSE
NC score	0.052942 (rank : 820)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	217	Target Neighborhood Hits	952	Shared Neighborhood Hits	49
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

EDD1_HUMAN
NC score	0.052914 (rank : 821)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	217	Target Neighborhood Hits	170	Shared Neighborhood Hits	12
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
NC score	0.052831 (rank : 822)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	217	Target Neighborhood Hits	167	Shared Neighborhood Hits	11
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

KC1G3_HUMAN
NC score	0.052804 (rank : 823)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	217	Target Neighborhood Hits	711	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

MK01_HUMAN
NC score	0.052736 (rank : 824)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

FGR_HUMAN
NC score	0.052725 (rank : 825)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	217	Target Neighborhood Hits	1067	Shared Neighborhood Hits	56
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MK01_MOUSE
NC score	0.052704 (rank : 826)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	217	Target Neighborhood Hits	836	Shared Neighborhood Hits	39
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MOK_MOUSE
NC score	0.052699 (rank : 827)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	217	Target Neighborhood Hits	796	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MK03_MOUSE
NC score	0.052695 (rank : 828)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	217	Target Neighborhood Hits	840	Shared Neighborhood Hits	39
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

LRRK2_MOUSE
NC score	0.052540 (rank : 829)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	217	Target Neighborhood Hits	1359	Shared Neighborhood Hits	39
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

P3C2G_MOUSE
NC score	0.052414 (rank : 830)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	217	Target Neighborhood Hits	113	Shared Neighborhood Hits	49
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

MK03_HUMAN
NC score	0.052411 (rank : 831)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

SRMS_MOUSE
NC score	0.052346 (rank : 832)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	217	Target Neighborhood Hits	964	Shared Neighborhood Hits	52
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

YES_MOUSE
NC score	0.052143 (rank : 833)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	217	Target Neighborhood Hits	1052	Shared Neighborhood Hits	56
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

MATK_HUMAN
NC score	0.052019 (rank : 834)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	217	Target Neighborhood Hits	954	Shared Neighborhood Hits	50
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

YES_HUMAN
NC score	0.052014 (rank : 835)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	217	Target Neighborhood Hits	1059	Shared Neighborhood Hits	56
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FNBP2_HUMAN
NC score	0.052009 (rank : 836)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	217	Target Neighborhood Hits	432	Shared Neighborhood Hits	35
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GAK_HUMAN
NC score	0.051834 (rank : 837)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	217	Target Neighborhood Hits	1028	Shared Neighborhood Hits	42
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MK06_HUMAN
NC score	0.051808 (rank : 838)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	217	Target Neighborhood Hits	815	Shared Neighborhood Hits	41
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

AL2S2_HUMAN
NC score	0.051751 (rank : 839)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	217	Target Neighborhood Hits	727	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

FES_MOUSE
NC score	0.051693 (rank : 840)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	217	Target Neighborhood Hits	980	Shared Neighborhood Hits	41
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

BLK_HUMAN
NC score	0.051475 (rank : 841)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	217	Target Neighborhood Hits	994	Shared Neighborhood Hits	53
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

3BP1_MOUSE
NC score	0.051466 (rank : 842)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	217	Target Neighborhood Hits	238	Shared Neighborhood Hits	15
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TYK2_HUMAN
NC score	0.051381 (rank : 843)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	217	Target Neighborhood Hits	841	Shared Neighborhood Hits	39
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

MK04_HUMAN
NC score	0.051323 (rank : 844)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	217	Target Neighborhood Hits	837	Shared Neighborhood Hits	39
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

AL2S2_MOUSE
NC score	0.051275 (rank : 845)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	217	Target Neighborhood Hits	709	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

STYK1_MOUSE
NC score	0.051191 (rank : 846)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	217	Target Neighborhood Hits	779	Shared Neighborhood Hits	39
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

CD2L6_MOUSE
NC score	0.051188 (rank : 847)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	217	Target Neighborhood Hits	851	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

MK06_MOUSE
NC score	0.051097 (rank : 848)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	217	Target Neighborhood Hits	818	Shared Neighborhood Hits	41
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

RHG25_MOUSE
NC score	0.051032 (rank : 849)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	217	Target Neighborhood Hits	492	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

KC1G2_HUMAN
NC score	0.051025 (rank : 850)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	217	Target Neighborhood Hits	693	Shared Neighborhood Hits	39
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

AATK_MOUSE
NC score	0.050964 (rank : 851)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	217	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

3BP1_HUMAN
NC score	0.050942 (rank : 852)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	217	Target Neighborhood Hits	376	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

FGR_MOUSE
NC score	0.050921 (rank : 853)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	217	Target Neighborhood Hits	1069	Shared Neighborhood Hits	56
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LCK_MOUSE
NC score	0.050876 (rank : 854)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	217	Target Neighborhood Hits	981	Shared Neighborhood Hits	53
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SYGP1_HUMAN
NC score	0.050824 (rank : 855)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	217	Target Neighborhood Hits	589	Shared Neighborhood Hits	28
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

CD2L6_HUMAN
NC score	0.050771 (rank : 856)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	217	Target Neighborhood Hits	844	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

OPHN1_HUMAN
NC score	0.050748 (rank : 857)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	217	Target Neighborhood Hits	161	Shared Neighborhood Hits	16
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

AATK_HUMAN
NC score	0.050339 (rank : 858)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	217	Target Neighborhood Hits	1243	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

BUB1_MOUSE
NC score	0.050330 (rank : 859)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	217	Target Neighborhood Hits	583	Shared Neighborhood Hits	36
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

SRGP2_HUMAN
NC score	0.050259 (rank : 860)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	217	Target Neighborhood Hits	331	Shared Neighborhood Hits	30
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

BLK_MOUSE
NC score	0.050219 (rank : 861)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	217	Target Neighborhood Hits	992	Shared Neighborhood Hits	53
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CLK1_HUMAN
NC score	0.050160 (rank : 862)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	217	Target Neighborhood Hits	756	Shared Neighborhood Hits	40
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

SRMS_HUMAN
NC score	0.050121 (rank : 863)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	217	Target Neighborhood Hits	946	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRGP2_MOUSE
NC score	0.050105 (rank : 864)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	217	Target Neighborhood Hits	324	Shared Neighborhood Hits	30
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

IWS1_MOUSE
NC score	0.030136 (rank : 865)	θ value	3.0926 (rank : 180)
Query Neighborhood Hits	217	Target Neighborhood Hits	1258	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

CAN6_MOUSE
NC score	0.029082 (rank : 866)	θ value	1.81305 (rank : 173)
Query Neighborhood Hits	217	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	O35646	Gene names	Capn6, Capa6
Domain Architecture
Description	Calpain-6.

PININ_HUMAN
NC score	0.027980 (rank : 867)	θ value	6.88961 (rank : 207)
Query Neighborhood Hits	217	Target Neighborhood Hits	753	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

GLU2B_HUMAN
NC score	0.026040 (rank : 868)	θ value	6.88961 (rank : 203)
Query Neighborhood Hits	217	Target Neighborhood Hits	377	Shared Neighborhood Hits	17
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

HUTU_HUMAN
NC score	0.024558 (rank : 869)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	217	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q96N76	Gene names	UROC1
Domain Architecture
Description	Probable urocanate hydratase (EC 4.2.1.49) (Urocanase) (Imidazolonepropionate hydrolase).

PININ_MOUSE
NC score	0.024402 (rank : 870)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	217	Target Neighborhood Hits	777	Shared Neighborhood Hits	31
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

CLSPN_HUMAN
NC score	0.024226 (rank : 871)	θ value	1.38821 (rank : 170)
Query Neighborhood Hits	217	Target Neighborhood Hits	433	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

CAN6_HUMAN
NC score	0.021001 (rank : 872)	θ value	6.88961 (rank : 202)
Query Neighborhood Hits	217	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6Q1, Q9UEQ1, Q9UJA8	Gene names	CAPN6, CALPM, CANPX
Domain Architecture
Description	Calpain-6 (Calpamodulin) (CalpM) (Calpain-like protease X-linked).

CMGA_HUMAN
NC score	0.018034 (rank : 873)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	217	Target Neighborhood Hits	238	Shared Neighborhood Hits	9
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

MOES_HUMAN
NC score	0.017629 (rank : 874)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	217	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

CROCC_HUMAN
NC score	0.016914 (rank : 875)	θ value	8.99809 (rank : 210)
Query Neighborhood Hits	217	Target Neighborhood Hits	1409	Shared Neighborhood Hits	38
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

NIN_HUMAN
NC score	0.016473 (rank : 876)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	217	Target Neighborhood Hits	1416	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

BAZ1B_HUMAN
NC score	0.014458 (rank : 877)	θ value	3.0926 (rank : 179)
Query Neighborhood Hits	217	Target Neighborhood Hits	701	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

MOES_MOUSE
NC score	0.013548 (rank : 878)	θ value	6.88961 (rank : 205)
Query Neighborhood Hits	217	Target Neighborhood Hits	923	Shared Neighborhood Hits	26
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYT1L_HUMAN
NC score	0.013116 (rank : 879)	θ value	3.0926 (rank : 183)
Query Neighborhood Hits	217	Target Neighborhood Hits	471	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UL68, Q6IQ17, Q9UPP6	Gene names	MYT1L, KIAA1106
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L).

CCNT1_MOUSE
NC score	0.012286 (rank : 880)	θ value	2.36792 (rank : 178)
Query Neighborhood Hits	217	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QWV9, Q9Z0U7	Gene names	Ccnt1
Domain Architecture
Description	Cyclin-T1 (CycT1) (Cyclin-T).

FBXL5_MOUSE
NC score	0.011049 (rank : 881)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	217	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C2S5, Q3TWC9, Q80XI5, Q8BGF5, Q8BNL3, Q8C3Q8	Gene names	Fbxl5
Domain Architecture
Description	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5).

BAI2_HUMAN
NC score	0.010257 (rank : 882)	θ value	5.27518 (rank : 191)
Query Neighborhood Hits	217	Target Neighborhood Hits	332	Shared Neighborhood Hits	9
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
NC score	0.009673 (rank : 883)	θ value	5.27518 (rank : 192)
Query Neighborhood Hits	217	Target Neighborhood Hits	323	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI3_HUMAN
NC score	0.009532 (rank : 884)	θ value	5.27518 (rank : 193)
Query Neighborhood Hits	217	Target Neighborhood Hits	246	Shared Neighborhood Hits	7
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

DOCK4_MOUSE
NC score	0.009346 (rank : 885)	θ value	4.03905 (rank : 187)
Query Neighborhood Hits	217	Target Neighborhood Hits	210	Shared Neighborhood Hits	10
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

NFM_HUMAN
NC score	0.009337 (rank : 886)	θ value	6.88961 (rank : 206)
Query Neighborhood Hits	217	Target Neighborhood Hits	1328	Shared Neighborhood Hits	35
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

ZNFX1_HUMAN
NC score	0.006945 (rank : 887)	θ value	3.0926 (rank : 184)
Query Neighborhood Hits	217	Target Neighborhood Hits	308	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

RNF13_MOUSE
NC score	0.006535 (rank : 888)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	217	Target Neighborhood Hits	164	Shared Neighborhood Hits	2
SwissProt Accessions	O54965, O54966	Gene names	Rnf13, Rzf
Domain Architecture
Description	RING finger protein 13.

ANR12_HUMAN
NC score	0.006343 (rank : 889)	θ value	6.88961 (rank : 201)
Query Neighborhood Hits	217	Target Neighborhood Hits	1081	Shared Neighborhood Hits	22
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

HHLA2_HUMAN
NC score	0.006282 (rank : 890)	θ value	8.99809 (rank : 212)
Query Neighborhood Hits	217	Target Neighborhood Hits	140	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

WDR12_HUMAN
NC score	0.005830 (rank : 891)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	217	Target Neighborhood Hits	300	Shared Neighborhood Hits	5
SwissProt Accessions	Q9GZL7, Q96HU0, Q9NV80, Q9NYI8	Gene names	WDR12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

RPTN_MOUSE
NC score	0.003401 (rank : 892)	θ value	6.88961 (rank : 209)
Query Neighborhood Hits	217	Target Neighborhood Hits	650	Shared Neighborhood Hits	14
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

COR2B_HUMAN
NC score	0.002778 (rank : 893)	θ value	4.03905 (rank : 186)
Query Neighborhood Hits	217	Target Neighborhood Hits	233	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UQ03, O94767, Q8TAN1	Gene names	CORO2B, KIAA0925
Domain Architecture
Description	Coronin-2B (Coronin-like protein C) (ClipinC) (Protein FC96).

KCNV2_HUMAN
NC score	0.000379 (rank : 894)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	217	Target Neighborhood Hits	137	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).