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Network neighborhood for query Sequence : RHG26_HUMAN

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RHG26_HUMAN
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RHG26_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	281	Target Neighborhood Hits	281	Shared Neighborhood Hits	281
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

OPHN1_HUMAN
θ value	1.19313e-177 (rank : 2)	NC score	0.908646 (rank : 2)
Query Neighborhood Hits	281	Target Neighborhood Hits	161	Shared Neighborhood Hits	84
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	1.90485e-175 (rank : 3)	NC score	0.907613 (rank : 3)
Query Neighborhood Hits	281	Target Neighborhood Hits	174	Shared Neighborhood Hits	88
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

CHIO_MOUSE
θ value	2.86786e-30 (rank : 4)	NC score	0.723235 (rank : 11)
Query Neighborhood Hits	281	Target Neighborhood Hits	130	Shared Neighborhood Hits	71
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_HUMAN
θ value	1.85889e-29 (rank : 5)	NC score	0.710471 (rank : 16)
Query Neighborhood Hits	281	Target Neighborhood Hits	220	Shared Neighborhood Hits	92
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_MOUSE
θ value	3.17079e-29 (rank : 6)	NC score	0.711736 (rank : 15)
Query Neighborhood Hits	281	Target Neighborhood Hits	229	Shared Neighborhood Hits	95
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
θ value	5.40856e-29 (rank : 7)	NC score	0.710460 (rank : 17)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	93
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CENB2_HUMAN
θ value	6.18819e-25 (rank : 8)	NC score	0.270112 (rank : 92)
Query Neighborhood Hits	281	Target Neighborhood Hits	425	Shared Neighborhood Hits	35
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

RHG12_HUMAN
θ value	1.5242e-23 (rank : 9)	NC score	0.743431 (rank : 6)
Query Neighborhood Hits	281	Target Neighborhood Hits	190	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	2.59989e-23 (rank : 10)	NC score	0.742889 (rank : 7)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GRLF1_HUMAN
θ value	2.87452e-22 (rank : 11)	NC score	0.715389 (rank : 14)
Query Neighborhood Hits	281	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

RHG09_HUMAN
θ value	4.9032e-22 (rank : 12)	NC score	0.769929 (rank : 4)
Query Neighborhood Hits	281	Target Neighborhood Hits	186	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RGAP1_HUMAN
θ value	1.09232e-21 (rank : 13)	NC score	0.740376 (rank : 8)
Query Neighborhood Hits	281	Target Neighborhood Hits	189	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

CENB5_HUMAN
θ value	2.43343e-21 (rank : 14)	NC score	0.264139 (rank : 97)
Query Neighborhood Hits	281	Target Neighborhood Hits	395	Shared Neighborhood Hits	31
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

TCGAP_MOUSE
θ value	1.5773e-20 (rank : 15)	NC score	0.752847 (rank : 5)
Query Neighborhood Hits	281	Target Neighborhood Hits	409	Shared Neighborhood Hits	147
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_HUMAN
θ value	4.58923e-20 (rank : 16)	NC score	0.669469 (rank : 31)
Query Neighborhood Hits	281	Target Neighborhood Hits	872	Shared Neighborhood Hits	150
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RGAP1_MOUSE
θ value	7.82807e-20 (rank : 17)	NC score	0.738101 (rank : 9)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

BCR_HUMAN
θ value	1.74391e-19 (rank : 18)	NC score	0.668015 (rank : 33)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	80
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
θ value	1.13037e-18 (rank : 19)	NC score	0.672942 (rank : 27)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	77
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

GMIP_MOUSE
θ value	1.13037e-18 (rank : 20)	NC score	0.729013 (rank : 10)
Query Neighborhood Hits	281	Target Neighborhood Hits	202	Shared Neighborhood Hits	72
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

3BP1_HUMAN
θ value	1.63225e-17 (rank : 21)	NC score	0.703791 (rank : 19)
Query Neighborhood Hits	281	Target Neighborhood Hits	376	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CEND2_HUMAN
θ value	2.13179e-17 (rank : 22)	NC score	0.603843 (rank : 40)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

MYO9B_MOUSE
θ value	3.63628e-17 (rank : 23)	NC score	0.390243 (rank : 59)
Query Neighborhood Hits	281	Target Neighborhood Hits	311	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

GMIP_HUMAN
θ value	6.20254e-17 (rank : 24)	NC score	0.721728 (rank : 12)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	73
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

MYO9B_HUMAN
θ value	8.10077e-17 (rank : 25)	NC score	0.385227 (rank : 60)
Query Neighborhood Hits	281	Target Neighborhood Hits	641	Shared Neighborhood Hits	84
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

RHG05_HUMAN
θ value	4.02038e-16 (rank : 26)	NC score	0.676217 (rank : 26)
Query Neighborhood Hits	281	Target Neighborhood Hits	158	Shared Neighborhood Hits	65
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_MOUSE
θ value	5.25075e-16 (rank : 27)	NC score	0.680191 (rank : 25)
Query Neighborhood Hits	281	Target Neighborhood Hits	165	Shared Neighborhood Hits	66
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

3BP1_MOUSE
θ value	6.85773e-16 (rank : 28)	NC score	0.708515 (rank : 18)
Query Neighborhood Hits	281	Target Neighborhood Hits	238	Shared Neighborhood Hits	80
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

DP13A_MOUSE
θ value	8.95645e-16 (rank : 29)	NC score	0.353957 (rank : 62)
Query Neighborhood Hits	281	Target Neighborhood Hits	96	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_HUMAN
θ value	1.16975e-15 (rank : 30)	NC score	0.355526 (rank : 61)
Query Neighborhood Hits	281	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

RBP1_MOUSE
θ value	1.52774e-15 (rank : 31)	NC score	0.650580 (rank : 35)
Query Neighborhood Hits	281	Target Neighborhood Hits	493	Shared Neighborhood Hits	91
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

CENB1_HUMAN
θ value	2.60593e-15 (rank : 32)	NC score	0.248374 (rank : 118)
Query Neighborhood Hits	281	Target Neighborhood Hits	383	Shared Neighborhood Hits	31
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

RBP1_HUMAN
θ value	2.20605e-14 (rank : 33)	NC score	0.635142 (rank : 38)
Query Neighborhood Hits	281	Target Neighborhood Hits	521	Shared Neighborhood Hits	93
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG25_HUMAN
θ value	4.91457e-14 (rank : 34)	NC score	0.625215 (rank : 39)
Query Neighborhood Hits	281	Target Neighborhood Hits	550	Shared Neighborhood Hits	98
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

DP13B_MOUSE
θ value	6.41864e-14 (rank : 35)	NC score	0.341619 (rank : 63)
Query Neighborhood Hits	281	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

RHG06_MOUSE
θ value	8.38298e-14 (rank : 36)	NC score	0.688131 (rank : 22)
Query Neighborhood Hits	281	Target Neighborhood Hits	105	Shared Neighborhood Hits	61
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG25_MOUSE
θ value	1.09485e-13 (rank : 37)	NC score	0.639328 (rank : 37)
Query Neighborhood Hits	281	Target Neighborhood Hits	492	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG04_HUMAN
θ value	5.43371e-13 (rank : 38)	NC score	0.716174 (rank : 13)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	170
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRGP2_HUMAN
θ value	5.43371e-13 (rank : 39)	NC score	0.689972 (rank : 21)
Query Neighborhood Hits	281	Target Neighborhood Hits	331	Shared Neighborhood Hits	171
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

DP13B_HUMAN
θ value	9.26847e-13 (rank : 40)	NC score	0.333335 (rank : 64)
Query Neighborhood Hits	281	Target Neighborhood Hits	58	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

RHG06_HUMAN
θ value	9.26847e-13 (rank : 41)	NC score	0.690301 (rank : 20)
Query Neighborhood Hits	281	Target Neighborhood Hits	114	Shared Neighborhood Hits	63
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG18_HUMAN
θ value	9.26847e-13 (rank : 42)	NC score	0.682144 (rank : 24)
Query Neighborhood Hits	281	Target Neighborhood Hits	90	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

SRGP2_MOUSE
θ value	4.59992e-12 (rank : 43)	NC score	0.682992 (rank : 23)
Query Neighborhood Hits	281	Target Neighborhood Hits	324	Shared Neighborhood Hits	171
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RHG07_HUMAN
θ value	1.02475e-11 (rank : 44)	NC score	0.592193 (rank : 42)
Query Neighborhood Hits	281	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG18_MOUSE
θ value	2.28291e-11 (rank : 45)	NC score	0.672450 (rank : 28)
Query Neighborhood Hits	281	Target Neighborhood Hits	110	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

SRGP1_HUMAN
θ value	2.98157e-11 (rank : 46)	NC score	0.670984 (rank : 29)
Query Neighborhood Hits	281	Target Neighborhood Hits	390	Shared Neighborhood Hits	165
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RHG08_HUMAN
θ value	3.89403e-11 (rank : 47)	NC score	0.648029 (rank : 36)
Query Neighborhood Hits	281	Target Neighborhood Hits	88	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG07_MOUSE
θ value	5.08577e-11 (rank : 48)	NC score	0.595874 (rank : 41)
Query Neighborhood Hits	281	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG08_MOUSE
θ value	1.133e-10 (rank : 49)	NC score	0.652243 (rank : 34)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

CE005_MOUSE
θ value	7.34386e-10 (rank : 50)	NC score	0.557128 (rank : 47)
Query Neighborhood Hits	281	Target Neighborhood Hits	238	Shared Neighborhood Hits	72
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CE005_HUMAN
θ value	9.59137e-10 (rank : 51)	NC score	0.560228 (rank : 45)
Query Neighborhood Hits	281	Target Neighborhood Hits	213	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

FNBP2_HUMAN
θ value	1.63604e-09 (rank : 52)	NC score	0.670315 (rank : 30)
Query Neighborhood Hits	281	Target Neighborhood Hits	432	Shared Neighborhood Hits	175
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

STAR8_HUMAN
θ value	1.63604e-09 (rank : 53)	NC score	0.552719 (rank : 49)
Query Neighborhood Hits	281	Target Neighborhood Hits	216	Shared Neighborhood Hits	66
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_MOUSE
θ value	2.79066e-09 (rank : 54)	NC score	0.556607 (rank : 48)
Query Neighborhood Hits	281	Target Neighborhood Hits	101	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

RHG01_HUMAN
θ value	3.64472e-09 (rank : 55)	NC score	0.669119 (rank : 32)
Query Neighborhood Hits	281	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

CEND3_MOUSE
θ value	8.11959e-09 (rank : 56)	NC score	0.558597 (rank : 46)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
θ value	1.38499e-08 (rank : 57)	NC score	0.549887 (rank : 51)
Query Neighborhood Hits	281	Target Neighborhood Hits	275	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND1_MOUSE
θ value	2.36244e-08 (rank : 58)	NC score	0.513584 (rank : 53)
Query Neighborhood Hits	281	Target Neighborhood Hits	260	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

STA13_HUMAN
θ value	2.36244e-08 (rank : 59)	NC score	0.551703 (rank : 50)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

CEND1_HUMAN
θ value	8.97725e-08 (rank : 60)	NC score	0.493879 (rank : 54)
Query Neighborhood Hits	281	Target Neighborhood Hits	284	Shared Neighborhood Hits	69
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

STA13_MOUSE
θ value	1.53129e-07 (rank : 61)	NC score	0.541627 (rank : 52)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CD2AP_HUMAN
θ value	5.81887e-07 (rank : 62)	NC score	0.327611 (rank : 65)
Query Neighborhood Hits	281	Target Neighborhood Hits	315	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	5.81887e-07 (rank : 63)	NC score	0.327322 (rank : 66)
Query Neighborhood Hits	281	Target Neighborhood Hits	336	Shared Neighborhood Hits	143
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

TAGAP_HUMAN
θ value	9.92553e-07 (rank : 64)	NC score	0.581371 (rank : 43)
Query Neighborhood Hits	281	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

ITSN2_MOUSE
θ value	1.87187e-05 (rank : 65)	NC score	0.212836 (rank : 141)
Query Neighborhood Hits	281	Target Neighborhood Hits	1371	Shared Neighborhood Hits	184
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DNMBP_HUMAN
θ value	2.44474e-05 (rank : 66)	NC score	0.255886 (rank : 107)
Query Neighborhood Hits	281	Target Neighborhood Hits	413	Shared Neighborhood Hits	150
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NEBL_HUMAN
θ value	2.44474e-05 (rank : 67)	NC score	0.230504 (rank : 128)
Query Neighborhood Hits	281	Target Neighborhood Hits	457	Shared Neighborhood Hits	148
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

P85A_HUMAN
θ value	2.44474e-05 (rank : 68)	NC score	0.413842 (rank : 57)
Query Neighborhood Hits	281	Target Neighborhood Hits	479	Shared Neighborhood Hits	149
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

GRAP2_HUMAN
θ value	3.19293e-05 (rank : 69)	NC score	0.262560 (rank : 98)
Query Neighborhood Hits	281	Target Neighborhood Hits	304	Shared Neighborhood Hits	138
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ITSN2_HUMAN
θ value	4.1701e-05 (rank : 70)	NC score	0.219920 (rank : 135)
Query Neighborhood Hits	281	Target Neighborhood Hits	1173	Shared Neighborhood Hits	182
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SH3K1_MOUSE
θ value	4.1701e-05 (rank : 71)	NC score	0.324209 (rank : 67)
Query Neighborhood Hits	281	Target Neighborhood Hits	332	Shared Neighborhood Hits	135
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

DNMBP_MOUSE
θ value	5.44631e-05 (rank : 72)	NC score	0.252694 (rank : 114)
Query Neighborhood Hits	281	Target Neighborhood Hits	435	Shared Neighborhood Hits	150
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MYO1E_HUMAN
θ value	5.44631e-05 (rank : 73)	NC score	0.147115 (rank : 186)
Query Neighborhood Hits	281	Target Neighborhood Hits	293	Shared Neighborhood Hits	130
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SH3K1_HUMAN
θ value	5.44631e-05 (rank : 74)	NC score	0.319980 (rank : 68)
Query Neighborhood Hits	281	Target Neighborhood Hits	341	Shared Neighborhood Hits	137
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ARHG7_HUMAN
θ value	7.1131e-05 (rank : 75)	NC score	0.255179 (rank : 112)
Query Neighborhood Hits	281	Target Neighborhood Hits	347	Shared Neighborhood Hits	140
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GRAP2_MOUSE
θ value	7.1131e-05 (rank : 76)	NC score	0.264743 (rank : 96)
Query Neighborhood Hits	281	Target Neighborhood Hits	297	Shared Neighborhood Hits	137
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PACN2_HUMAN
θ value	7.1131e-05 (rank : 77)	NC score	0.275886 (rank : 89)
Query Neighborhood Hits	281	Target Neighborhood Hits	339	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

GRB2_HUMAN
θ value	9.29e-05 (rank : 78)	NC score	0.276225 (rank : 86)
Query Neighborhood Hits	281	Target Neighborhood Hits	310	Shared Neighborhood Hits	138
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	9.29e-05 (rank : 79)	NC score	0.276178 (rank : 87)
Query Neighborhood Hits	281	Target Neighborhood Hits	312	Shared Neighborhood Hits	138
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

TAGAP_MOUSE
θ value	9.29e-05 (rank : 80)	NC score	0.580592 (rank : 44)
Query Neighborhood Hits	281	Target Neighborhood Hits	83	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

ABI2_HUMAN
θ value	0.000121331 (rank : 81)	NC score	0.303839 (rank : 71)
Query Neighborhood Hits	281	Target Neighborhood Hits	350	Shared Neighborhood Hits	132
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.000121331 (rank : 82)	NC score	0.307972 (rank : 69)
Query Neighborhood Hits	281	Target Neighborhood Hits	266	Shared Neighborhood Hits	130
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ITSN1_HUMAN
θ value	0.000121331 (rank : 83)	NC score	0.212940 (rank : 140)
Query Neighborhood Hits	281	Target Neighborhood Hits	1757	Shared Neighborhood Hits	192
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

P85A_MOUSE
θ value	0.000158464 (rank : 84)	NC score	0.407924 (rank : 58)
Query Neighborhood Hits	281	Target Neighborhood Hits	435	Shared Neighborhood Hits	150
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PACN2_MOUSE
θ value	0.000158464 (rank : 85)	NC score	0.270420 (rank : 91)
Query Neighborhood Hits	281	Target Neighborhood Hits	382	Shared Neighborhood Hits	147
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ITSN1_MOUSE
θ value	0.00035302 (rank : 86)	NC score	0.211406 (rank : 144)
Query Neighborhood Hits	281	Target Neighborhood Hits	1669	Shared Neighborhood Hits	189
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ABI1_MOUSE
θ value	0.000602161 (rank : 87)	NC score	0.298200 (rank : 73)
Query Neighborhood Hits	281	Target Neighborhood Hits	246	Shared Neighborhood Hits	127
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ARHG6_HUMAN
θ value	0.000602161 (rank : 88)	NC score	0.241711 (rank : 124)
Query Neighborhood Hits	281	Target Neighborhood Hits	376	Shared Neighborhood Hits	141
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.000602161 (rank : 89)	NC score	0.246401 (rank : 122)
Query Neighborhood Hits	281	Target Neighborhood Hits	394	Shared Neighborhood Hits	143
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PACN1_HUMAN
θ value	0.000602161 (rank : 90)	NC score	0.269431 (rank : 94)
Query Neighborhood Hits	281	Target Neighborhood Hits	320	Shared Neighborhood Hits	150
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PEX13_MOUSE
θ value	0.000602161 (rank : 91)	NC score	0.222086 (rank : 132)
Query Neighborhood Hits	281	Target Neighborhood Hits	126	Shared Neighborhood Hits	95
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SRC8_HUMAN
θ value	0.000602161 (rank : 92)	NC score	0.286674 (rank : 80)
Query Neighborhood Hits	281	Target Neighborhood Hits	269	Shared Neighborhood Hits	136
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ABI1_HUMAN
θ value	0.000786445 (rank : 93)	NC score	0.288151 (rank : 77)
Query Neighborhood Hits	281	Target Neighborhood Hits	257	Shared Neighborhood Hits	127
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ARHG7_MOUSE
θ value	0.000786445 (rank : 94)	NC score	0.259541 (rank : 100)
Query Neighborhood Hits	281	Target Neighborhood Hits	396	Shared Neighborhood Hits	142
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

NEBU_HUMAN
θ value	0.000786445 (rank : 95)	NC score	0.205989 (rank : 146)
Query Neighborhood Hits	281	Target Neighborhood Hits	420	Shared Neighborhood Hits	133
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SH3G2_MOUSE
θ value	0.000786445 (rank : 96)	NC score	0.292269 (rank : 74)
Query Neighborhood Hits	281	Target Neighborhood Hits	319	Shared Neighborhood Hits	143
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SNX9_MOUSE
θ value	0.000786445 (rank : 97)	NC score	0.152016 (rank : 178)
Query Neighborhood Hits	281	Target Neighborhood Hits	141	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

PACN1_MOUSE
θ value	0.00102713 (rank : 98)	NC score	0.269591 (rank : 93)
Query Neighborhood Hits	281	Target Neighborhood Hits	283	Shared Neighborhood Hits	142
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PLCG1_MOUSE
θ value	0.00102713 (rank : 99)	NC score	0.194275 (rank : 152)
Query Neighborhood Hits	281	Target Neighborhood Hits	314	Shared Neighborhood Hits	123
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G1_HUMAN
θ value	0.00102713 (rank : 100)	NC score	0.277509 (rank : 84)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	148
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

NCK1_HUMAN
θ value	0.00134147 (rank : 101)	NC score	0.251712 (rank : 115)
Query Neighborhood Hits	281	Target Neighborhood Hits	312	Shared Neighborhood Hits	135
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PACN3_HUMAN
θ value	0.00134147 (rank : 102)	NC score	0.255201 (rank : 111)
Query Neighborhood Hits	281	Target Neighborhood Hits	385	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.00134147 (rank : 103)	NC score	0.259454 (rank : 101)
Query Neighborhood Hits	281	Target Neighborhood Hits	380	Shared Neighborhood Hits	143
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	0.00134147 (rank : 104)	NC score	0.220001 (rank : 134)
Query Neighborhood Hits	281	Target Neighborhood Hits	128	Shared Neighborhood Hits	91
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

VINEX_MOUSE
θ value	0.00134147 (rank : 105)	NC score	0.304560 (rank : 70)
Query Neighborhood Hits	281	Target Neighborhood Hits	286	Shared Neighborhood Hits	144
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DDFL1_HUMAN
θ value	0.00228821 (rank : 106)	NC score	0.153959 (rank : 177)
Query Neighborhood Hits	281	Target Neighborhood Hits	353	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

K1688_MOUSE
θ value	0.00228821 (rank : 107)	NC score	0.460360 (rank : 55)
Query Neighborhood Hits	281	Target Neighborhood Hits	188	Shared Neighborhood Hits	66
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

PLCG1_HUMAN
θ value	0.00228821 (rank : 108)	NC score	0.189168 (rank : 158)
Query Neighborhood Hits	281	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G2_HUMAN
θ value	0.00228821 (rank : 109)	NC score	0.290433 (rank : 75)
Query Neighborhood Hits	281	Target Neighborhood Hits	324	Shared Neighborhood Hits	147
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

STAM1_HUMAN
θ value	0.00228821 (rank : 110)	NC score	0.248134 (rank : 119)
Query Neighborhood Hits	281	Target Neighborhood Hits	271	Shared Neighborhood Hits	134
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	0.00228821 (rank : 111)	NC score	0.247200 (rank : 121)
Query Neighborhood Hits	281	Target Neighborhood Hits	273	Shared Neighborhood Hits	132
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI3_HUMAN
θ value	0.00298849 (rank : 112)	NC score	0.261734 (rank : 99)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	113
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PLCG2_HUMAN
θ value	0.00298849 (rank : 113)	NC score	0.188019 (rank : 160)
Query Neighborhood Hits	281	Target Neighborhood Hits	280	Shared Neighborhood Hits	115
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV_HUMAN
θ value	0.00298849 (rank : 114)	NC score	0.211150 (rank : 145)
Query Neighborhood Hits	281	Target Neighborhood Hits	452	Shared Neighborhood Hits	148
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	0.00298849 (rank : 115)	NC score	0.213542 (rank : 139)
Query Neighborhood Hits	281	Target Neighborhood Hits	430	Shared Neighborhood Hits	146
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ABI3_MOUSE
θ value	0.00390308 (rank : 116)	NC score	0.258894 (rank : 102)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G1_MOUSE
θ value	0.00390308 (rank : 117)	NC score	0.276336 (rank : 85)
Query Neighborhood Hits	281	Target Neighborhood Hits	291	Shared Neighborhood Hits	144
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SNX9_HUMAN
θ value	0.00390308 (rank : 118)	NC score	0.157946 (rank : 173)
Query Neighborhood Hits	281	Target Neighborhood Hits	148	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SRC8_MOUSE
θ value	0.00390308 (rank : 119)	NC score	0.286209 (rank : 81)
Query Neighborhood Hits	281	Target Neighborhood Hits	292	Shared Neighborhood Hits	134
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

K1688_HUMAN
θ value	0.00509761 (rank : 120)	NC score	0.445588 (rank : 56)
Query Neighborhood Hits	281	Target Neighborhood Hits	217	Shared Neighborhood Hits	61
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

CT2NL_HUMAN
θ value	0.00665767 (rank : 121)	NC score	0.059745 (rank : 297)
Query Neighborhood Hits	281	Target Neighborhood Hits	1059	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

LASP1_HUMAN
θ value	0.00665767 (rank : 122)	NC score	0.231956 (rank : 126)
Query Neighborhood Hits	281	Target Neighborhood Hits	293	Shared Neighborhood Hits	124
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00665767 (rank : 123)	NC score	0.231257 (rank : 127)
Query Neighborhood Hits	281	Target Neighborhood Hits	297	Shared Neighborhood Hits	124
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PICK1_MOUSE
θ value	0.0113563 (rank : 124)	NC score	0.052002 (rank : 342)
Query Neighborhood Hits	281	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SH3G3_MOUSE
θ value	0.0113563 (rank : 125)	NC score	0.279738 (rank : 83)
Query Neighborhood Hits	281	Target Neighborhood Hits	236	Shared Neighborhood Hits	136
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

CCD39_MOUSE
θ value	0.0148317 (rank : 126)	NC score	0.038205 (rank : 381)
Query Neighborhood Hits	281	Target Neighborhood Hits	1026	Shared Neighborhood Hits	52
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

HCLS1_HUMAN
θ value	0.0148317 (rank : 127)	NC score	0.289375 (rank : 76)
Query Neighborhood Hits	281	Target Neighborhood Hits	358	Shared Neighborhood Hits	128
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HIP1_HUMAN
θ value	0.0148317 (rank : 128)	NC score	0.035858 (rank : 385)
Query Neighborhood Hits	281	Target Neighborhood Hits	1016	Shared Neighborhood Hits	52
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

MYO1F_HUMAN
θ value	0.0148317 (rank : 129)	NC score	0.151201 (rank : 179)
Query Neighborhood Hits	281	Target Neighborhood Hits	275	Shared Neighborhood Hits	129
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NCF4_MOUSE
θ value	0.0148317 (rank : 130)	NC score	0.270997 (rank : 90)
Query Neighborhood Hits	281	Target Neighborhood Hits	177	Shared Neighborhood Hits	119
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

MYO1F_MOUSE
θ value	0.0193708 (rank : 131)	NC score	0.150256 (rank : 180)
Query Neighborhood Hits	281	Target Neighborhood Hits	262	Shared Neighborhood Hits	130
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

OSTF1_MOUSE
θ value	0.0193708 (rank : 132)	NC score	0.212709 (rank : 143)
Query Neighborhood Hits	281	Target Neighborhood Hits	467	Shared Neighborhood Hits	135
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PPIP1_HUMAN
θ value	0.0193708 (rank : 133)	NC score	0.255255 (rank : 110)
Query Neighborhood Hits	281	Target Neighborhood Hits	389	Shared Neighborhood Hits	155
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SHLB2_HUMAN
θ value	0.0193708 (rank : 134)	NC score	0.148927 (rank : 183)
Query Neighborhood Hits	281	Target Neighborhood Hits	86	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	0.0193708 (rank : 135)	NC score	0.148334 (rank : 184)
Query Neighborhood Hits	281	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

OSTF1_HUMAN
θ value	0.0252991 (rank : 136)	NC score	0.212718 (rank : 142)
Query Neighborhood Hits	281	Target Neighborhood Hits	466	Shared Neighborhood Hits	133
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3G3_HUMAN
θ value	0.0252991 (rank : 137)	NC score	0.276017 (rank : 88)
Query Neighborhood Hits	281	Target Neighborhood Hits	222	Shared Neighborhood Hits	137
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

VINEX_HUMAN
θ value	0.0252991 (rank : 138)	NC score	0.300714 (rank : 72)
Query Neighborhood Hits	281	Target Neighborhood Hits	270	Shared Neighborhood Hits	140
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

GRAP_HUMAN
θ value	0.0330416 (rank : 139)	NC score	0.256754 (rank : 105)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	133
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	0.0330416 (rank : 140)	NC score	0.258607 (rank : 103)
Query Neighborhood Hits	281	Target Neighborhood Hits	309	Shared Neighborhood Hits	137
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

HCLS1_MOUSE
θ value	0.0330416 (rank : 141)	NC score	0.287123 (rank : 79)
Query Neighborhood Hits	281	Target Neighborhood Hits	329	Shared Neighborhood Hits	132
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

P85B_HUMAN
θ value	0.0330416 (rank : 142)	NC score	0.160842 (rank : 169)
Query Neighborhood Hits	281	Target Neighborhood Hits	543	Shared Neighborhood Hits	102
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

RIMB2_MOUSE
θ value	0.0431538 (rank : 143)	NC score	0.173101 (rank : 167)
Query Neighborhood Hits	281	Target Neighborhood Hits	246	Shared Neighborhood Hits	100
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

BTK_HUMAN
θ value	0.0563607 (rank : 144)	NC score	0.054692 (rank : 323)
Query Neighborhood Hits	281	Target Neighborhood Hits	1026	Shared Neighborhood Hits	135
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FGR_HUMAN
θ value	0.0563607 (rank : 145)	NC score	0.068989 (rank : 271)
Query Neighborhood Hits	281	Target Neighborhood Hits	1067	Shared Neighborhood Hits	138
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

BAIP2_HUMAN
θ value	0.0736092 (rank : 146)	NC score	0.096426 (rank : 220)
Query Neighborhood Hits	281	Target Neighborhood Hits	192	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BTK_MOUSE
θ value	0.0736092 (rank : 147)	NC score	0.052576 (rank : 334)
Query Neighborhood Hits	281	Target Neighborhood Hits	1017	Shared Neighborhood Hits	130
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SNX18_MOUSE
θ value	0.0736092 (rank : 148)	NC score	0.195548 (rank : 151)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	112
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SRBS1_HUMAN
θ value	0.0736092 (rank : 149)	NC score	0.285414 (rank : 82)
Query Neighborhood Hits	281	Target Neighborhood Hits	396	Shared Neighborhood Hits	148
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM2_MOUSE
θ value	0.0736092 (rank : 150)	NC score	0.242603 (rank : 123)
Query Neighborhood Hits	281	Target Neighborhood Hits	285	Shared Neighborhood Hits	130
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TRI25_MOUSE
θ value	0.0736092 (rank : 151)	NC score	0.015061 (rank : 409)
Query Neighborhood Hits	281	Target Neighborhood Hits	446	Shared Neighborhood Hits	20
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

MY18A_HUMAN
θ value	0.0961366 (rank : 152)	NC score	0.060013 (rank : 295)
Query Neighborhood Hits	281	Target Neighborhood Hits	1929	Shared Neighborhood Hits	88
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NCF4_HUMAN
θ value	0.0961366 (rank : 153)	NC score	0.254774 (rank : 113)
Query Neighborhood Hits	281	Target Neighborhood Hits	161	Shared Neighborhood Hits	108
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

AKA11_HUMAN
θ value	0.125558 (rank : 154)	NC score	0.041430 (rank : 374)
Query Neighborhood Hits	281	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKA4, O75124, Q9NUK7	Gene names	AKAP11, AKAP220, KIAA0629
Domain Architecture
Description	A-kinase anchor protein 11 (Protein kinase A-anchoring protein 11) (PRKA11) (A kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220).

DBNL_HUMAN
θ value	0.125558 (rank : 155)	NC score	0.226834 (rank : 129)
Query Neighborhood Hits	281	Target Neighborhood Hits	244	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.125558 (rank : 156)	NC score	0.222171 (rank : 131)
Query Neighborhood Hits	281	Target Neighborhood Hits	306	Shared Neighborhood Hits	123
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

PICK1_HUMAN
θ value	0.125558 (rank : 157)	NC score	0.042972 (rank : 372)
Query Neighborhood Hits	281	Target Neighborhood Hits	132	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SRBS1_MOUSE
θ value	0.125558 (rank : 158)	NC score	0.287535 (rank : 78)
Query Neighborhood Hits	281	Target Neighborhood Hits	409	Shared Neighborhood Hits	147
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

BCAR1_HUMAN
θ value	0.163984 (rank : 159)	NC score	0.176418 (rank : 166)
Query Neighborhood Hits	281	Target Neighborhood Hits	554	Shared Neighborhood Hits	124
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DDEF1_MOUSE
θ value	0.163984 (rank : 160)	NC score	0.258336 (rank : 104)
Query Neighborhood Hits	281	Target Neighborhood Hits	592	Shared Neighborhood Hits	129
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FYN_HUMAN
θ value	0.163984 (rank : 161)	NC score	0.063845 (rank : 285)
Query Neighborhood Hits	281	Target Neighborhood Hits	1078	Shared Neighborhood Hits	138
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.163984 (rank : 162)	NC score	0.065583 (rank : 278)
Query Neighborhood Hits	281	Target Neighborhood Hits	1073	Shared Neighborhood Hits	138
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GCC2_MOUSE
θ value	0.163984 (rank : 163)	NC score	0.039836 (rank : 376)
Query Neighborhood Hits	281	Target Neighborhood Hits	1619	Shared Neighborhood Hits	76
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

MY18A_MOUSE
θ value	0.163984 (rank : 164)	NC score	0.059282 (rank : 299)
Query Neighborhood Hits	281	Target Neighborhood Hits	1989	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RIMB1_HUMAN
θ value	0.163984 (rank : 165)	NC score	0.111423 (rank : 202)
Query Neighborhood Hits	281	Target Neighborhood Hits	1479	Shared Neighborhood Hits	147
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	0.163984 (rank : 166)	NC score	0.105422 (rank : 209)
Query Neighborhood Hits	281	Target Neighborhood Hits	1376	Shared Neighborhood Hits	152
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	0.163984 (rank : 167)	NC score	0.168514 (rank : 168)
Query Neighborhood Hits	281	Target Neighborhood Hits	263	Shared Neighborhood Hits	101
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SNX18_HUMAN
θ value	0.163984 (rank : 168)	NC score	0.192913 (rank : 153)
Query Neighborhood Hits	281	Target Neighborhood Hits	207	Shared Neighborhood Hits	115
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

BCAR1_MOUSE
θ value	0.21417 (rank : 169)	NC score	0.185702 (rank : 163)
Query Neighborhood Hits	281	Target Neighborhood Hits	438	Shared Neighborhood Hits	125
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DDEF2_HUMAN
θ value	0.21417 (rank : 170)	NC score	0.255855 (rank : 108)
Query Neighborhood Hits	281	Target Neighborhood Hits	599	Shared Neighborhood Hits	132
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.21417 (rank : 171)	NC score	0.255387 (rank : 109)
Query Neighborhood Hits	281	Target Neighborhood Hits	625	Shared Neighborhood Hits	129
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EFS_HUMAN
θ value	0.21417 (rank : 172)	NC score	0.187506 (rank : 161)
Query Neighborhood Hits	281	Target Neighborhood Hits	348	Shared Neighborhood Hits	115
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	0.21417 (rank : 173)	NC score	0.186975 (rank : 162)
Query Neighborhood Hits	281	Target Neighborhood Hits	389	Shared Neighborhood Hits	118
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

RAD50_MOUSE
θ value	0.21417 (rank : 174)	NC score	0.047973 (rank : 365)
Query Neighborhood Hits	281	Target Neighborhood Hits	1366	Shared Neighborhood Hits	74
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

SRC_HUMAN
θ value	0.21417 (rank : 175)	NC score	0.062976 (rank : 288)
Query Neighborhood Hits	281	Target Neighborhood Hits	1058	Shared Neighborhood Hits	142
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

GOGA4_HUMAN
θ value	0.279714 (rank : 176)	NC score	0.043992 (rank : 371)
Query Neighborhood Hits	281	Target Neighborhood Hits	2034	Shared Neighborhood Hits	92
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

STAM2_HUMAN
θ value	0.279714 (rank : 177)	NC score	0.234674 (rank : 125)
Query Neighborhood Hits	281	Target Neighborhood Hits	288	Shared Neighborhood Hits	131
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

BAIP2_MOUSE
θ value	0.365318 (rank : 178)	NC score	0.094926 (rank : 225)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

SM1L2_MOUSE
θ value	0.365318 (rank : 179)	NC score	0.039467 (rank : 378)
Query Neighborhood Hits	281	Target Neighborhood Hits	918	Shared Neighborhood Hits	59
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

MDC1_HUMAN
θ value	0.47712 (rank : 180)	NC score	0.033508 (rank : 388)
Query Neighborhood Hits	281	Target Neighborhood Hits	1446	Shared Neighborhood Hits	59
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NCF2_HUMAN
θ value	0.47712 (rank : 181)	NC score	0.267634 (rank : 95)
Query Neighborhood Hits	281	Target Neighborhood Hits	229	Shared Neighborhood Hits	120
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PPIP1_MOUSE
θ value	0.47712 (rank : 182)	NC score	0.247834 (rank : 120)
Query Neighborhood Hits	281	Target Neighborhood Hits	377	Shared Neighborhood Hits	155
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SYCP1_MOUSE
θ value	0.47712 (rank : 183)	NC score	0.044503 (rank : 370)
Query Neighborhood Hits	281	Target Neighborhood Hits	1456	Shared Neighborhood Hits	75
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

BCN1_HUMAN
θ value	0.62314 (rank : 184)	NC score	0.030163 (rank : 392)
Query Neighborhood Hits	281	Target Neighborhood Hits	395	Shared Neighborhood Hits	31
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

CT032_HUMAN
θ value	0.62314 (rank : 185)	NC score	0.192301 (rank : 154)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	109
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

MAP4_HUMAN
θ value	0.62314 (rank : 186)	NC score	0.018550 (rank : 404)
Query Neighborhood Hits	281	Target Neighborhood Hits	428	Shared Neighborhood Hits	19
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MRCKB_MOUSE
θ value	0.62314 (rank : 187)	NC score	0.028738 (rank : 393)
Query Neighborhood Hits	281	Target Neighborhood Hits	2180	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NCK2_HUMAN
θ value	0.62314 (rank : 188)	NC score	0.256215 (rank : 106)
Query Neighborhood Hits	281	Target Neighborhood Hits	310	Shared Neighborhood Hits	138
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RXRA_HUMAN
θ value	0.62314 (rank : 189)	NC score	0.002499 (rank : 437)
Query Neighborhood Hits	281	Target Neighborhood Hits	223	Shared Neighborhood Hits	4
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

SHLB1_HUMAN
θ value	0.62314 (rank : 190)	NC score	0.143945 (rank : 187)
Query Neighborhood Hits	281	Target Neighborhood Hits	96	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	0.62314 (rank : 191)	NC score	0.147300 (rank : 185)
Query Neighborhood Hits	281	Target Neighborhood Hits	101	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

TP53B_MOUSE
θ value	0.62314 (rank : 192)	NC score	0.023406 (rank : 399)
Query Neighborhood Hits	281	Target Neighborhood Hits	644	Shared Neighborhood Hits	28
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

BI2L1_HUMAN
θ value	0.813845 (rank : 193)	NC score	0.095860 (rank : 222)
Query Neighborhood Hits	281	Target Neighborhood Hits	156	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SAS6_HUMAN
θ value	0.813845 (rank : 194)	NC score	0.037397 (rank : 383)
Query Neighborhood Hits	281	Target Neighborhood Hits	791	Shared Neighborhood Hits	50
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

CSPG2_MOUSE
θ value	1.06291 (rank : 195)	NC score	0.005841 (rank : 432)
Query Neighborhood Hits	281	Target Neighborhood Hits	711	Shared Neighborhood Hits	15
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

FOG2_MOUSE
θ value	1.06291 (rank : 196)	NC score	0.003148 (rank : 434)
Query Neighborhood Hits	281	Target Neighborhood Hits	714	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CCH7, Q9Z0F2	Gene names	Zfpm2, Fog2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (Friend of GATA-2) (FOG-2) (mFOG-2).

GCC2_HUMAN
θ value	1.06291 (rank : 197)	NC score	0.045282 (rank : 366)
Query Neighborhood Hits	281	Target Neighborhood Hits	1558	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

M3K9_HUMAN
θ value	1.06291 (rank : 198)	NC score	0.051134 (rank : 352)
Query Neighborhood Hits	281	Target Neighborhood Hits	1123	Shared Neighborhood Hits	129
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

RBP24_HUMAN
θ value	1.06291 (rank : 199)	NC score	0.045213 (rank : 367)
Query Neighborhood Hits	281	Target Neighborhood Hits	1559	Shared Neighborhood Hits	87
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

SAS6_MOUSE
θ value	1.06291 (rank : 200)	NC score	0.037764 (rank : 382)
Query Neighborhood Hits	281	Target Neighborhood Hits	931	Shared Neighborhood Hits	57
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

TBCD4_MOUSE
θ value	1.06291 (rank : 201)	NC score	0.013213 (rank : 415)
Query Neighborhood Hits	281	Target Neighborhood Hits	276	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BYJ6, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2	Gene names	Tbc1d4, Kiaa0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

YES_MOUSE
θ value	1.06291 (rank : 202)	NC score	0.063064 (rank : 286)
Query Neighborhood Hits	281	Target Neighborhood Hits	1052	Shared Neighborhood Hits	136
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

NIPBL_HUMAN
θ value	1.38821 (rank : 203)	NC score	0.012482 (rank : 416)
Query Neighborhood Hits	281	Target Neighborhood Hits	1311	Shared Neighborhood Hits	45
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

ROCK1_MOUSE
θ value	1.38821 (rank : 204)	NC score	0.017443 (rank : 405)
Query Neighborhood Hits	281	Target Neighborhood Hits	2126	Shared Neighborhood Hits	85
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

TRI37_HUMAN
θ value	1.38821 (rank : 205)	NC score	0.021904 (rank : 401)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	16
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	1.38821 (rank : 206)	NC score	0.022025 (rank : 400)
Query Neighborhood Hits	281	Target Neighborhood Hits	316	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

YES_HUMAN
θ value	1.38821 (rank : 207)	NC score	0.061553 (rank : 292)
Query Neighborhood Hits	281	Target Neighborhood Hits	1059	Shared Neighborhood Hits	136
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CASL_HUMAN
θ value	1.81305 (rank : 208)	NC score	0.157950 (rank : 172)
Query Neighborhood Hits	281	Target Neighborhood Hits	259	Shared Neighborhood Hits	114
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	1.81305 (rank : 209)	NC score	0.156771 (rank : 174)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	112
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CCD21_MOUSE
θ value	1.81305 (rank : 210)	NC score	0.032227 (rank : 389)
Query Neighborhood Hits	281	Target Neighborhood Hits	1135	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

DDFL1_MOUSE
θ value	1.81305 (rank : 211)	NC score	0.135643 (rank : 188)
Query Neighborhood Hits	281	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

ES8L3_MOUSE
θ value	1.81305 (rank : 212)	NC score	0.101485 (rank : 212)
Query Neighborhood Hits	281	Target Neighborhood Hits	168	Shared Neighborhood Hits	97
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FOG2_HUMAN
θ value	1.81305 (rank : 213)	NC score	0.002645 (rank : 436)
Query Neighborhood Hits	281	Target Neighborhood Hits	731	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WW38, Q9NPL7, Q9NPS4, Q9UNI5	Gene names	ZFPM2, FOG2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (FOG-2) (hFOG-2).

GOGA4_MOUSE
θ value	1.81305 (rank : 214)	NC score	0.039577 (rank : 377)
Query Neighborhood Hits	281	Target Neighborhood Hits	1939	Shared Neighborhood Hits	88
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

MASTL_MOUSE
θ value	1.81305 (rank : 215)	NC score	0.001426 (rank : 439)
Query Neighborhood Hits	281	Target Neighborhood Hits	862	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

SPN90_HUMAN
θ value	1.81305 (rank : 216)	NC score	0.109476 (rank : 204)
Query Neighborhood Hits	281	Target Neighborhood Hits	157	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

VAV3_HUMAN
θ value	1.81305 (rank : 217)	NC score	0.196506 (rank : 150)
Query Neighborhood Hits	281	Target Neighborhood Hits	398	Shared Neighborhood Hits	138
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

BRE1A_MOUSE
θ value	2.36792 (rank : 218)	NC score	0.030913 (rank : 391)
Query Neighborhood Hits	281	Target Neighborhood Hits	1025	Shared Neighborhood Hits	65
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

IASPP_MOUSE
θ value	2.36792 (rank : 219)	NC score	0.126982 (rank : 193)
Query Neighborhood Hits	281	Target Neighborhood Hits	1024	Shared Neighborhood Hits	131
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IRF2_MOUSE
θ value	2.36792 (rank : 220)	NC score	0.009335 (rank : 423)
Query Neighborhood Hits	281	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	P23906	Gene names	Irf2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

NPHP1_MOUSE
θ value	2.36792 (rank : 221)	NC score	0.177110 (rank : 165)
Query Neighborhood Hits	281	Target Neighborhood Hits	267	Shared Neighborhood Hits	116
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

TIP60_HUMAN
θ value	2.36792 (rank : 222)	NC score	0.013303 (rank : 412)
Query Neighborhood Hits	281	Target Neighborhood Hits	90	Shared Neighborhood Hits	6
SwissProt Accessions	Q92993, O95624, Q13430, Q6GSE8, Q9BWK7	Gene names	HTATIP, TIP60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60) (HIV-1 Tat interactive protein) (cPLA(2)-interacting protein).

TIP60_MOUSE
θ value	2.36792 (rank : 223)	NC score	0.013263 (rank : 413)
Query Neighborhood Hits	281	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHK4, Q8CGZ3, Q8CGZ4, Q8VIH0	Gene names	Htatip, Tip60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60).

ADO_HUMAN
θ value	3.0926 (rank : 224)	NC score	0.009035 (rank : 424)
Query Neighborhood Hits	281	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q06278, O14765, Q9UPG6	Gene names	AOX1, AO
Domain Architecture
Description	Aldehyde oxidase (EC 1.2.3.1).

ATX1_MOUSE
θ value	3.0926 (rank : 225)	NC score	0.016724 (rank : 407)
Query Neighborhood Hits	281	Target Neighborhood Hits	264	Shared Neighborhood Hits	11
SwissProt Accessions	P54254	Gene names	Atxn1, Sca1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).

CCDC5_HUMAN
θ value	3.0926 (rank : 226)	NC score	0.019059 (rank : 403)
Query Neighborhood Hits	281	Target Neighborhood Hits	125	Shared Neighborhood Hits	11
SwissProt Accessions	Q96CS2, Q8N837	Gene names	CCDC5, HEIC
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 5 (Enhancer of invasion-cluster) (HEI-C).

IASPP_HUMAN
θ value	3.0926 (rank : 227)	NC score	0.134195 (rank : 189)
Query Neighborhood Hits	281	Target Neighborhood Hits	688	Shared Neighborhood Hits	123
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

M3KL4_HUMAN
θ value	3.0926 (rank : 228)	NC score	0.056417 (rank : 314)
Query Neighborhood Hits	281	Target Neighborhood Hits	1087	Shared Neighborhood Hits	138
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MYCD_HUMAN
θ value	3.0926 (rank : 229)	NC score	0.008662 (rank : 426)
Query Neighborhood Hits	281	Target Neighborhood Hits	167	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZQ8, Q8N7Q1	Gene names	MYOCD, MYCD
Domain Architecture
Description	Myocardin.

SPN90_MOUSE
θ value	3.0926 (rank : 230)	NC score	0.096392 (rank : 221)
Query Neighborhood Hits	281	Target Neighborhood Hits	157	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

TARA_HUMAN
θ value	3.0926 (rank : 231)	NC score	0.028738 (rank : 394)
Query Neighborhood Hits	281	Target Neighborhood Hits	1626	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CCNB2_MOUSE
θ value	4.03905 (rank : 232)	NC score	0.005560 (rank : 433)
Query Neighborhood Hits	281	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P30276	Gene names	Ccnb2, Cycb2
Domain Architecture
Description	G2/mitotic-specific cyclin-B2.

CK5P2_HUMAN
θ value	4.03905 (rank : 233)	NC score	0.038584 (rank : 380)
Query Neighborhood Hits	281	Target Neighborhood Hits	1433	Shared Neighborhood Hits	75
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CYTSA_MOUSE
θ value	4.03905 (rank : 234)	NC score	0.031818 (rank : 390)
Query Neighborhood Hits	281	Target Neighborhood Hits	1104	Shared Neighborhood Hits	65
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

FGR_MOUSE
θ value	4.03905 (rank : 235)	NC score	0.062983 (rank : 287)
Query Neighborhood Hits	281	Target Neighborhood Hits	1069	Shared Neighborhood Hits	136
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

HSF1_HUMAN
θ value	4.03905 (rank : 236)	NC score	0.011470 (rank : 419)
Query Neighborhood Hits	281	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

NCOA5_MOUSE
θ value	4.03905 (rank : 237)	NC score	0.012350 (rank : 417)
Query Neighborhood Hits	281	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	Q91W39	Gene names	Ncoa5
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

PTK6_HUMAN
θ value	4.03905 (rank : 238)	NC score	0.035700 (rank : 387)
Query Neighborhood Hits	281	Target Neighborhood Hits	1020	Shared Neighborhood Hits	116
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

STS1_MOUSE
θ value	4.03905 (rank : 239)	NC score	0.086194 (rank : 232)
Query Neighborhood Hits	281	Target Neighborhood Hits	104	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

TARA_MOUSE
θ value	4.03905 (rank : 240)	NC score	0.042738 (rank : 373)
Query Neighborhood Hits	281	Target Neighborhood Hits	1133	Shared Neighborhood Hits	59
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

VAV3_MOUSE
θ value	4.03905 (rank : 241)	NC score	0.192278 (rank : 155)
Query Neighborhood Hits	281	Target Neighborhood Hits	404	Shared Neighborhood Hits	135
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARMC4_HUMAN
θ value	5.27518 (rank : 242)	NC score	0.009867 (rank : 422)
Query Neighborhood Hits	281	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

CSK_HUMAN
θ value	5.27518 (rank : 243)	NC score	0.044763 (rank : 369)
Query Neighborhood Hits	281	Target Neighborhood Hits	1009	Shared Neighborhood Hits	109
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	5.27518 (rank : 244)	NC score	0.044835 (rank : 368)
Query Neighborhood Hits	281	Target Neighborhood Hits	1009	Shared Neighborhood Hits	109
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

GP112_HUMAN
θ value	5.27518 (rank : 245)	NC score	0.001828 (rank : 438)
Query Neighborhood Hits	281	Target Neighborhood Hits	441	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

I5P2_HUMAN
θ value	5.27518 (rank : 246)	NC score	0.249299 (rank : 117)
Query Neighborhood Hits	281	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

KIF11_HUMAN
θ value	5.27518 (rank : 247)	NC score	0.013777 (rank : 411)
Query Neighborhood Hits	281	Target Neighborhood Hits	583	Shared Neighborhood Hits	45
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

LMNB1_MOUSE
θ value	5.27518 (rank : 248)	NC score	0.015178 (rank : 408)
Query Neighborhood Hits	281	Target Neighborhood Hits	719	Shared Neighborhood Hits	46
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

MRCKB_HUMAN
θ value	5.27518 (rank : 249)	NC score	0.025439 (rank : 398)
Query Neighborhood Hits	281	Target Neighborhood Hits	2239	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MUCDL_MOUSE
θ value	5.27518 (rank : 250)	NC score	0.008703 (rank : 425)
Query Neighborhood Hits	281	Target Neighborhood Hits	461	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NRG3_HUMAN
θ value	5.27518 (rank : 251)	NC score	0.012022 (rank : 418)
Query Neighborhood Hits	281	Target Neighborhood Hits	119	Shared Neighborhood Hits	7
SwissProt Accessions	P56975	Gene names	NRG3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

SLK_MOUSE
θ value	5.27518 (rank : 252)	NC score	0.008236 (rank : 429)
Query Neighborhood Hits	281	Target Neighborhood Hits	1798	Shared Neighborhood Hits	76
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SMC2_HUMAN
θ value	5.27518 (rank : 253)	NC score	0.035953 (rank : 384)
Query Neighborhood Hits	281	Target Neighborhood Hits	1405	Shared Neighborhood Hits	76
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

STS1_HUMAN
θ value	5.27518 (rank : 254)	NC score	0.084539 (rank : 234)
Query Neighborhood Hits	281	Target Neighborhood Hits	106	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

CP250_HUMAN
θ value	6.88961 (rank : 255)	NC score	0.038639 (rank : 379)
Query Neighborhood Hits	281	Target Neighborhood Hits	1805	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CRKL_HUMAN
θ value	6.88961 (rank : 256)	NC score	0.215155 (rank : 138)
Query Neighborhood Hits	281	Target Neighborhood Hits	313	Shared Neighborhood Hits	135
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

DCP1A_HUMAN
θ value	6.88961 (rank : 257)	NC score	0.013945 (rank : 410)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

LIMD1_MOUSE
θ value	6.88961 (rank : 258)	NC score	0.003007 (rank : 435)
Query Neighborhood Hits	281	Target Neighborhood Hits	291	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

MCEE_HUMAN
θ value	6.88961 (rank : 259)	NC score	0.011376 (rank : 420)
Query Neighborhood Hits	281	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PE7, Q8WW63	Gene names	MCEE
Domain Architecture	No domain graphic available
Description	Methylmalonyl-CoA epimerase, mitochondrial precursor (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase).

MO4L2_HUMAN
θ value	6.88961 (rank : 260)	NC score	0.010289 (rank : 421)
Query Neighborhood Hits	281	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q15014, Q567V0, Q8J026	Gene names	MORF4L2, KIAA0026, MRGX
Domain Architecture
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (MSL3-2 protein).

MO4L2_MOUSE
θ value	6.88961 (rank : 261)	NC score	0.008255 (rank : 428)
Query Neighborhood Hits	281	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R0Q4, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2	Gene names	Morf4l2, Kiaa0026, Sid393
Domain Architecture	No domain graphic available
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (Sid 393).

P85B_MOUSE
θ value	6.88961 (rank : 262)	NC score	0.127395 (rank : 192)
Query Neighborhood Hits	281	Target Neighborhood Hits	519	Shared Neighborhood Hits	98
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SLK_HUMAN
θ value	6.88961 (rank : 263)	NC score	0.008371 (rank : 427)
Query Neighborhood Hits	281	Target Neighborhood Hits	1775	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

STAC3_HUMAN
θ value	6.88961 (rank : 264)	NC score	0.217373 (rank : 137)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	118
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	6.88961 (rank : 265)	NC score	0.218455 (rank : 136)
Query Neighborhood Hits	281	Target Neighborhood Hits	232	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TSH1_MOUSE
θ value	6.88961 (rank : 266)	NC score	0.000127 (rank : 440)
Query Neighborhood Hits	281	Target Neighborhood Hits	675	Shared Neighborhood Hits	5
SwissProt Accessions	Q5DTH5, Q6PE60, Q8VD19, Q9JLD5	Gene names	Tshz1, Kiaa4206, Sdccag33, Tsh1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog).

CCD42_HUMAN
θ value	8.99809 (rank : 267)	NC score	0.025443 (rank : 397)
Query Neighborhood Hits	281	Target Neighborhood Hits	406	Shared Neighborhood Hits	39
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

CCD46_MOUSE
θ value	8.99809 (rank : 268)	NC score	0.041356 (rank : 375)
Query Neighborhood Hits	281	Target Neighborhood Hits	1405	Shared Neighborhood Hits	78
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CF152_HUMAN
θ value	8.99809 (rank : 269)	NC score	0.027833 (rank : 395)
Query Neighborhood Hits	281	Target Neighborhood Hits	704	Shared Neighborhood Hits	47
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

COG7_HUMAN
θ value	8.99809 (rank : 270)	NC score	0.019976 (rank : 402)
Query Neighborhood Hits	281	Target Neighborhood Hits	108	Shared Neighborhood Hits	8
SwissProt Accessions	P83436, Q6UWU7	Gene names	COG7
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 7.

DCP1A_MOUSE
θ value	8.99809 (rank : 271)	NC score	0.013221 (rank : 414)
Query Neighborhood Hits	281	Target Neighborhood Hits	103	Shared Neighborhood Hits	8
SwissProt Accessions	Q91YD3, Q6NZE3	Gene names	Dcp1a, Mitc1, Smif
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (MAD homolog 4-interacting transcription coactivator 1) (Smad4-interacting transcriptional co-activator).

GZF1_HUMAN
θ value	8.99809 (rank : 272)	NC score	-0.010229 (rank : 442)
Query Neighborhood Hits	281	Target Neighborhood Hits	854	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H116, Q96N08, Q9BQK9, Q9H117, Q9H6W6	Gene names	GZF1, ZBTB23, ZNF336
Domain Architecture
Description	GDNF-inducible zinc finger protein 1 (Zinc finger protein 336) (Zinc finger and BTB domain-containing protein 23).

NCOA6_MOUSE
θ value	8.99809 (rank : 273)	NC score	0.016757 (rank : 406)
Query Neighborhood Hits	281	Target Neighborhood Hits	1076	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PPIP2_MOUSE
θ value	8.99809 (rank : 274)	NC score	0.055162 (rank : 320)
Query Neighborhood Hits	281	Target Neighborhood Hits	308	Shared Neighborhood Hits	35
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

SLIK1_MOUSE
θ value	8.99809 (rank : 275)	NC score	-0.003067 (rank : 441)
Query Neighborhood Hits	281	Target Neighborhood Hits	333	Shared Neighborhood Hits	3
SwissProt Accessions	Q810C1, Q9CXL0	Gene names	Slitrk1, Sltk1
Domain Architecture
Description	SLIT and NTRK-like protein 1 precursor.

SMC4_MOUSE
θ value	8.99809 (rank : 276)	NC score	0.025561 (rank : 396)
Query Neighborhood Hits	281	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

SVIL_MOUSE
θ value	8.99809 (rank : 277)	NC score	0.006356 (rank : 430)
Query Neighborhood Hits	281	Target Neighborhood Hits	439	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TPR_HUMAN
θ value	8.99809 (rank : 278)	NC score	0.035771 (rank : 386)
Query Neighborhood Hits	281	Target Neighborhood Hits	1921	Shared Neighborhood Hits	83
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TTLL5_HUMAN
θ value	8.99809 (rank : 279)	NC score	0.006200 (rank : 431)
Query Neighborhood Hits	281	Target Neighborhood Hits	141	Shared Neighborhood Hits	6
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

VAV2_HUMAN
θ value	8.99809 (rank : 280)	NC score	0.197187 (rank : 149)
Query Neighborhood Hits	281	Target Neighborhood Hits	453	Shared Neighborhood Hits	142
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	8.99809 (rank : 281)	NC score	0.197679 (rank : 148)
Query Neighborhood Hits	281	Target Neighborhood Hits	456	Shared Neighborhood Hits	142
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

AHI1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.155516 (rank : 175)
Query Neighborhood Hits	281	Target Neighborhood Hits	537	Shared Neighborhood Hits	136
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.154735 (rank : 176)
Query Neighborhood Hits	281	Target Neighborhood Hits	496	Shared Neighborhood Hits	133
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AMPH_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.069011 (rank : 270)
Query Neighborhood Hits	281	Target Neighborhood Hits	455	Shared Neighborhood Hits	78
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.062574 (rank : 290)
Query Neighborhood Hits	281	Target Neighborhood Hits	291	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.112112 (rank : 201)
Query Neighborhood Hits	281	Target Neighborhood Hits	175	Shared Neighborhood Hits	103
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.109899 (rank : 203)
Query Neighborhood Hits	281	Target Neighborhood Hits	175	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APS_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.057408 (rank : 308)
Query Neighborhood Hits	281	Target Neighborhood Hits	162	Shared Neighborhood Hits	34
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARFG1_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.094748 (rank : 226)
Query Neighborhood Hits	281	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.099022 (rank : 215)
Query Neighborhood Hits	281	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.097660 (rank : 217)
Query Neighborhood Hits	281	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.096860 (rank : 219)
Query Neighborhood Hits	281	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARHG3_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.071396 (rank : 264)
Query Neighborhood Hits	281	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.071060 (rank : 265)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.160809 (rank : 170)
Query Neighborhood Hits	281	Target Neighborhood Hits	242	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.121815 (rank : 195)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.095584 (rank : 224)
Query Neighborhood Hits	281	Target Neighborhood Hits	172	Shared Neighborhood Hits	73
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.065033 (rank : 280)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.072116 (rank : 261)
Query Neighborhood Hits	281	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.149829 (rank : 182)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	112
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.149996 (rank : 181)
Query Neighborhood Hits	281	Target Neighborhood Hits	234	Shared Neighborhood Hits	112
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.076784 (rank : 246)
Query Neighborhood Hits	281	Target Neighborhood Hits	187	Shared Neighborhood Hits	25
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.075806 (rank : 248)
Query Neighborhood Hits	281	Target Neighborhood Hits	125	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.064992 (rank : 281)
Query Neighborhood Hits	281	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.076449 (rank : 247)
Query Neighborhood Hits	281	Target Neighborhood Hits	152	Shared Neighborhood Hits	50
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.114678 (rank : 198)
Query Neighborhood Hits	281	Target Neighborhood Hits	956	Shared Neighborhood Hits	155
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.113569 (rank : 200)
Query Neighborhood Hits	281	Target Neighborhood Hits	1244	Shared Neighborhood Hits	157
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.095653 (rank : 223)
Query Neighborhood Hits	281	Target Neighborhood Hits	1156	Shared Neighborhood Hits	144
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BI2L1_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.081110 (rank : 239)
Query Neighborhood Hits	281	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.062696 (rank : 289)
Query Neighborhood Hits	281	Target Neighborhood Hits	335	Shared Neighborhood Hits	69
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.066859 (rank : 275)
Query Neighborhood Hits	281	Target Neighborhood Hits	283	Shared Neighborhood Hits	69
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CENA1_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.105431 (rank : 208)
Query Neighborhood Hits	281	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.104192 (rank : 211)
Query Neighborhood Hits	281	Target Neighborhood Hits	83	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA2_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.099180 (rank : 214)
Query Neighborhood Hits	281	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CENG1_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.085989 (rank : 233)
Query Neighborhood Hits	281	Target Neighborhood Hits	544	Shared Neighborhood Hits	19
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.088620 (rank : 229)
Query Neighborhood Hits	281	Target Neighborhood Hits	531	Shared Neighborhood Hits	21
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.073151 (rank : 255)
Query Neighborhood Hits	281	Target Neighborhood Hits	471	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.073238 (rank : 253)
Query Neighborhood Hits	281	Target Neighborhood Hits	463	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG3_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.079257 (rank : 244)
Query Neighborhood Hits	281	Target Neighborhood Hits	455	Shared Neighborhood Hits	15
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.080825 (rank : 240)
Query Neighborhood Hits	281	Target Neighborhood Hits	467	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CIP4_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.114058 (rank : 199)
Query Neighborhood Hits	281	Target Neighborhood Hits	374	Shared Neighborhood Hits	81
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRKL_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.205105 (rank : 147)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	131
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.188071 (rank : 159)
Query Neighborhood Hits	281	Target Neighborhood Hits	308	Shared Neighborhood Hits	130
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.191475 (rank : 156)
Query Neighborhood Hits	281	Target Neighborhood Hits	314	Shared Neighborhood Hits	130
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.118296 (rank : 197)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.121964 (rank : 194)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DGKD_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.051447 (rank : 349)
Query Neighborhood Hits	281	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.058530 (rank : 302)
Query Neighborhood Hits	281	Target Neighborhood Hits	255	Shared Neighborhood Hits	33
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DOCK1_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.064979 (rank : 282)
Query Neighborhood Hits	281	Target Neighborhood Hits	191	Shared Neighborhood Hits	91
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ECT2_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.067251 (rank : 274)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.068176 (rank : 272)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EPS8_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.065991 (rank : 276)
Query Neighborhood Hits	281	Target Neighborhood Hits	151	Shared Neighborhood Hits	74
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.070232 (rank : 267)
Query Neighborhood Hits	281	Target Neighborhood Hits	157	Shared Neighborhood Hits	85
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.058562 (rank : 301)
Query Neighborhood Hits	281	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.060052 (rank : 294)
Query Neighborhood Hits	281	Target Neighborhood Hits	143	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.072351 (rank : 260)
Query Neighborhood Hits	281	Target Neighborhood Hits	193	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.070049 (rank : 268)
Query Neighborhood Hits	281	Target Neighborhood Hits	169	Shared Neighborhood Hits	85
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.081130 (rank : 238)
Query Neighborhood Hits	281	Target Neighborhood Hits	206	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FA13A_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.056952 (rank : 311)
Query Neighborhood Hits	281	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

FA13A_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.055997 (rank : 316)
Query Neighborhood Hits	281	Target Neighborhood Hits	83	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

FGD1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.052501 (rank : 336)
Query Neighborhood Hits	281	Target Neighborhood Hits	367	Shared Neighborhood Hits	33
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.050502 (rank : 358)
Query Neighborhood Hits	281	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD3_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.050489 (rank : 359)
Query Neighborhood Hits	281	Target Neighborhood Hits	257	Shared Neighborhood Hits	22
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.056993 (rank : 310)
Query Neighborhood Hits	281	Target Neighborhood Hits	219	Shared Neighborhood Hits	33
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.061268 (rank : 293)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

GIT1_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.072787 (rank : 256)
Query Neighborhood Hits	281	Target Neighborhood Hits	336	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.072039 (rank : 262)
Query Neighborhood Hits	281	Target Neighborhood Hits	341	Shared Neighborhood Hits	20
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GIT2_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.072519 (rank : 257)
Query Neighborhood Hits	281	Target Neighborhood Hits	381	Shared Neighborhood Hits	21
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.072517 (rank : 258)
Query Neighborhood Hits	281	Target Neighborhood Hits	323	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GNRP_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.067789 (rank : 273)
Query Neighborhood Hits	281	Target Neighborhood Hits	239	Shared Neighborhood Hits	31
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.064590 (rank : 283)
Query Neighborhood Hits	281	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB14_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.051097 (rank : 353)
Query Neighborhood Hits	281	Target Neighborhood Hits	137	Shared Neighborhood Hits	35
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRP3_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.088741 (rank : 228)
Query Neighborhood Hits	281	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HRBL_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.054083 (rank : 326)
Query Neighborhood Hits	281	Target Neighborhood Hits	179	Shared Neighborhood Hits	15
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.054368 (rank : 325)
Query Neighborhood Hits	281	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

M3K11_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.050003 (rank : 364)
Query Neighborhood Hits	281	Target Neighborhood Hits	1136	Shared Neighborhood Hits	130
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MCF2L_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.054804 (rank : 322)
Query Neighborhood Hits	281	Target Neighborhood Hits	255	Shared Neighborhood Hits	38
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.058106 (rank : 306)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	26
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MYH11_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.052056 (rank : 339)
Query Neighborhood Hits	281	Target Neighborhood Hits	1806	Shared Neighborhood Hits	99
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.052040 (rank : 341)
Query Neighborhood Hits	281	Target Neighborhood Hits	1777	Shared Neighborhood Hits	95
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.050419 (rank : 361)
Query Neighborhood Hits	281	Target Neighborhood Hits	1478	Shared Neighborhood Hits	86
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.051636 (rank : 346)
Query Neighborhood Hits	281	Target Neighborhood Hits	1461	Shared Neighborhood Hits	89
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH2_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.050454 (rank : 360)
Query Neighborhood Hits	281	Target Neighborhood Hits	1491	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH3_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.053450 (rank : 327)
Query Neighborhood Hits	281	Target Neighborhood Hits	1660	Shared Neighborhood Hits	94
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH8_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.053112 (rank : 330)
Query Neighborhood Hits	281	Target Neighborhood Hits	1610	Shared Neighborhood Hits	90
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.052649 (rank : 332)
Query Neighborhood Hits	281	Target Neighborhood Hits	1600	Shared Neighborhood Hits	87
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH9_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.051164 (rank : 351)
Query Neighborhood Hits	281	Target Neighborhood Hits	1762	Shared Neighborhood Hits	88
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.051672 (rank : 345)
Query Neighborhood Hits	281	Target Neighborhood Hits	1829	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYO10_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.069054 (rank : 269)
Query Neighborhood Hits	281	Target Neighborhood Hits	920	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYO15_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.052116 (rank : 338)
Query Neighborhood Hits	281	Target Neighborhood Hits	467	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO5A_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.052576 (rank : 335)
Query Neighborhood Hits	281	Target Neighborhood Hits	1092	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MYO5A_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.053312 (rank : 328)
Query Neighborhood Hits	281	Target Neighborhood Hits	1117	Shared Neighborhood Hits	62
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5B_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.050886 (rank : 355)
Query Neighborhood Hits	281	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

MYO5C_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.053261 (rank : 329)
Query Neighborhood Hits	281	Target Neighborhood Hits	1206	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYO6_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.051217 (rank : 350)
Query Neighborhood Hits	281	Target Neighborhood Hits	727	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO7A_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.050383 (rank : 362)
Query Neighborhood Hits	281	Target Neighborhood Hits	209	Shared Neighborhood Hits	31
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO7A_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.052270 (rank : 337)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	35
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

NCF1_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.184639 (rank : 164)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	111
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.191025 (rank : 157)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	121
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NGEF_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.082457 (rank : 237)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.083023 (rank : 236)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	73
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.080718 (rank : 241)
Query Neighborhood Hits	281	Target Neighborhood Hits	100	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.128046 (rank : 191)
Query Neighborhood Hits	281	Target Neighborhood Hits	114	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.158367 (rank : 171)
Query Neighborhood Hits	281	Target Neighborhood Hits	288	Shared Neighborhood Hits	114
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NUPL_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.058406 (rank : 304)
Query Neighborhood Hits	281	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.057313 (rank : 309)
Query Neighborhood Hits	281	Target Neighborhood Hits	113	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

OCRL_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.249449 (rank : 116)
Query Neighborhood Hits	281	Target Neighborhood Hits	77	Shared Neighborhood Hits	50
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

P55G_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.101133 (rank : 213)
Query Neighborhood Hits	281	Target Neighborhood Hits	451	Shared Neighborhood Hits	66
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.097133 (rank : 218)
Query Neighborhood Hits	281	Target Neighborhood Hits	401	Shared Neighborhood Hits	60
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PCTL_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.052047 (rank : 340)
Query Neighborhood Hits	281	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.052631 (rank : 333)
Query Neighborhood Hits	281	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PDZD8_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.059442 (rank : 298)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PKHA1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.071887 (rank : 263)
Query Neighborhood Hits	281	Target Neighborhood Hits	127	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.065908 (rank : 277)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.051054 (rank : 354)
Query Neighborhood Hits	281	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.051674 (rank : 344)
Query Neighborhood Hits	281	Target Neighborhood Hits	283	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.050334 (rank : 363)
Query Neighborhood Hits	281	Target Neighborhood Hits	202	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA6_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.056461 (rank : 313)
Query Neighborhood Hits	281	Target Neighborhood Hits	556	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.058529 (rank : 303)
Query Neighborhood Hits	281	Target Neighborhood Hits	591	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHG1_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.072352 (rank : 259)
Query Neighborhood Hits	281	Target Neighborhood Hits	174	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PPIP2_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.055748 (rank : 318)
Query Neighborhood Hits	281	Target Neighborhood Hits	254	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PREX1_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.074767 (rank : 250)
Query Neighborhood Hits	281	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RASA1_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.083770 (rank : 235)
Query Neighborhood Hits	281	Target Neighborhood Hits	258	Shared Neighborhood Hits	52
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RGNEF_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.056511 (rank : 312)
Query Neighborhood Hits	281	Target Neighborhood Hits	641	Shared Neighborhood Hits	54
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RUSC1_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.130943 (rank : 190)
Query Neighborhood Hits	281	Target Neighborhood Hits	226	Shared Neighborhood Hits	100
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.119964 (rank : 196)
Query Neighborhood Hits	281	Target Neighborhood Hits	206	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH21A_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.065270 (rank : 279)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.063865 (rank : 284)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	23
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.057826 (rank : 307)
Query Neighborhood Hits	281	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.062213 (rank : 291)
Query Neighborhood Hits	281	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHAN1_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.070975 (rank : 266)
Query Neighborhood Hits	281	Target Neighborhood Hits	1041	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.080243 (rank : 242)
Query Neighborhood Hits	281	Target Neighborhood Hits	446	Shared Neighborhood Hits	87
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.054971 (rank : 321)
Query Neighborhood Hits	281	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.054606 (rank : 324)
Query Neighborhood Hits	281	Target Neighborhood Hits	137	Shared Neighborhood Hits	35
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.050770 (rank : 356)
Query Neighborhood Hits	281	Target Neighborhood Hits	170	Shared Neighborhood Hits	38
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.055396 (rank : 319)
Query Neighborhood Hits	281	Target Neighborhood Hits	180	Shared Neighborhood Hits	39
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.050600 (rank : 357)
Query Neighborhood Hits	281	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.052975 (rank : 331)
Query Neighborhood Hits	281	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHD_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.051895 (rank : 343)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	35
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.058922 (rank : 300)
Query Neighborhood Hits	281	Target Neighborhood Hits	137	Shared Neighborhood Hits	38
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SLAP1_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.075252 (rank : 249)
Query Neighborhood Hits	281	Target Neighborhood Hits	113	Shared Neighborhood Hits	34
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.078083 (rank : 245)
Query Neighborhood Hits	281	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.074214 (rank : 251)
Query Neighborhood Hits	281	Target Neighborhood Hits	139	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.079324 (rank : 243)
Query Neighborhood Hits	281	Target Neighborhood Hits	136	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.055945 (rank : 317)
Query Neighborhood Hits	281	Target Neighborhood Hits	108	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SMAP1_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.104885 (rank : 210)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.106986 (rank : 206)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.107007 (rank : 205)
Query Neighborhood Hits	281	Target Neighborhood Hits	74	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.106180 (rank : 207)
Query Neighborhood Hits	281	Target Neighborhood Hits	70	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SPTA1_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.087238 (rank : 230)
Query Neighborhood Hits	281	Target Neighborhood Hits	748	Shared Neighborhood Hits	156
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.089476 (rank : 227)
Query Neighborhood Hits	281	Target Neighborhood Hits	675	Shared Neighborhood Hits	146
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.098942 (rank : 216)
Query Neighborhood Hits	281	Target Neighborhood Hits	888	Shared Neighborhood Hits	158
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAC_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.222970 (rank : 130)
Query Neighborhood Hits	281	Target Neighborhood Hits	276	Shared Neighborhood Hits	128
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.221976 (rank : 133)
Query Neighborhood Hits	281	Target Neighborhood Hits	268	Shared Neighborhood Hits	126
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STS2_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.086456 (rank : 231)
Query Neighborhood Hits	281	Target Neighborhood Hits	108	Shared Neighborhood Hits	67
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCRG1_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.051474 (rank : 348)
Query Neighborhood Hits	281	Target Neighborhood Hits	929	Shared Neighborhood Hits	50
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.051627 (rank : 347)
Query Neighborhood Hits	281	Target Neighborhood Hits	947	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TIAM1_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.074172 (rank : 252)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.073164 (rank : 254)
Query Neighborhood Hits	281	Target Neighborhood Hits	205	Shared Neighborhood Hits	22
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

UN13A_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.059896 (rank : 296)
Query Neighborhood Hits	281	Target Neighborhood Hits	285	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.058137 (rank : 305)
Query Neighborhood Hits	281	Target Neighborhood Hits	217	Shared Neighborhood Hits	25
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.056199 (rank : 315)
Query Neighborhood Hits	281	Target Neighborhood Hits	210	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

Hits sorted by NC score

RHG26_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	281	Target Neighborhood Hits	281	Shared Neighborhood Hits	281
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

OPHN1_HUMAN
NC score	0.908646 (rank : 2)	θ value	1.19313e-177 (rank : 2)
Query Neighborhood Hits	281	Target Neighborhood Hits	161	Shared Neighborhood Hits	84
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
NC score	0.907613 (rank : 3)	θ value	1.90485e-175 (rank : 3)
Query Neighborhood Hits	281	Target Neighborhood Hits	174	Shared Neighborhood Hits	88
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG09_HUMAN
NC score	0.769929 (rank : 4)	θ value	4.9032e-22 (rank : 12)
Query Neighborhood Hits	281	Target Neighborhood Hits	186	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

TCGAP_MOUSE
NC score	0.752847 (rank : 5)	θ value	1.5773e-20 (rank : 15)
Query Neighborhood Hits	281	Target Neighborhood Hits	409	Shared Neighborhood Hits	147
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG12_HUMAN
NC score	0.743431 (rank : 6)	θ value	1.5242e-23 (rank : 9)
Query Neighborhood Hits	281	Target Neighborhood Hits	190	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.742889 (rank : 7)	θ value	2.59989e-23 (rank : 10)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RGAP1_HUMAN
NC score	0.740376 (rank : 8)	θ value	1.09232e-21 (rank : 13)
Query Neighborhood Hits	281	Target Neighborhood Hits	189	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
NC score	0.738101 (rank : 9)	θ value	7.82807e-20 (rank : 17)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GMIP_MOUSE
NC score	0.729013 (rank : 10)	θ value	1.13037e-18 (rank : 20)
Query Neighborhood Hits	281	Target Neighborhood Hits	202	Shared Neighborhood Hits	72
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

CHIO_MOUSE
NC score	0.723235 (rank : 11)	θ value	2.86786e-30 (rank : 4)
Query Neighborhood Hits	281	Target Neighborhood Hits	130	Shared Neighborhood Hits	71
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GMIP_HUMAN
NC score	0.721728 (rank : 12)	θ value	6.20254e-17 (rank : 24)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	73
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG04_HUMAN
NC score	0.716174 (rank : 13)	θ value	5.43371e-13 (rank : 38)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	170
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

GRLF1_HUMAN
NC score	0.715389 (rank : 14)	θ value	2.87452e-22 (rank : 11)
Query Neighborhood Hits	281	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

CHIN_MOUSE
NC score	0.711736 (rank : 15)	θ value	3.17079e-29 (rank : 6)
Query Neighborhood Hits	281	Target Neighborhood Hits	229	Shared Neighborhood Hits	95
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.710471 (rank : 16)	θ value	1.85889e-29 (rank : 5)
Query Neighborhood Hits	281	Target Neighborhood Hits	220	Shared Neighborhood Hits	92
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_HUMAN
NC score	0.710460 (rank : 17)	θ value	5.40856e-29 (rank : 7)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	93
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

3BP1_MOUSE
NC score	0.708515 (rank : 18)	θ value	6.85773e-16 (rank : 28)
Query Neighborhood Hits	281	Target Neighborhood Hits	238	Shared Neighborhood Hits	80
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

3BP1_HUMAN
NC score	0.703791 (rank : 19)	θ value	1.63225e-17 (rank : 21)
Query Neighborhood Hits	281	Target Neighborhood Hits	376	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG06_HUMAN
NC score	0.690301 (rank : 20)	θ value	9.26847e-13 (rank : 41)
Query Neighborhood Hits	281	Target Neighborhood Hits	114	Shared Neighborhood Hits	63
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SRGP2_HUMAN
NC score	0.689972 (rank : 21)	θ value	5.43371e-13 (rank : 39)
Query Neighborhood Hits	281	Target Neighborhood Hits	331	Shared Neighborhood Hits	171
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RHG06_MOUSE
NC score	0.688131 (rank : 22)	θ value	8.38298e-14 (rank : 36)
Query Neighborhood Hits	281	Target Neighborhood Hits	105	Shared Neighborhood Hits	61
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SRGP2_MOUSE
NC score	0.682992 (rank : 23)	θ value	4.59992e-12 (rank : 43)
Query Neighborhood Hits	281	Target Neighborhood Hits	324	Shared Neighborhood Hits	171
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RHG18_HUMAN
NC score	0.682144 (rank : 24)	θ value	9.26847e-13 (rank : 42)
Query Neighborhood Hits	281	Target Neighborhood Hits	90	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG05_MOUSE
NC score	0.680191 (rank : 25)	θ value	5.25075e-16 (rank : 27)
Query Neighborhood Hits	281	Target Neighborhood Hits	165	Shared Neighborhood Hits	66
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_HUMAN
NC score	0.676217 (rank : 26)	θ value	4.02038e-16 (rank : 26)
Query Neighborhood Hits	281	Target Neighborhood Hits	158	Shared Neighborhood Hits	65
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

ABR_HUMAN
NC score	0.672942 (rank : 27)	θ value	1.13037e-18 (rank : 19)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	77
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG18_MOUSE
NC score	0.672450 (rank : 28)	θ value	2.28291e-11 (rank : 45)
Query Neighborhood Hits	281	Target Neighborhood Hits	110	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

SRGP1_HUMAN
NC score	0.670984 (rank : 29)	θ value	2.98157e-11 (rank : 46)
Query Neighborhood Hits	281	Target Neighborhood Hits	390	Shared Neighborhood Hits	165
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.670315 (rank : 30)	θ value	1.63604e-09 (rank : 52)
Query Neighborhood Hits	281	Target Neighborhood Hits	432	Shared Neighborhood Hits	175
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

TCGAP_HUMAN
NC score	0.669469 (rank : 31)	θ value	4.58923e-20 (rank : 16)
Query Neighborhood Hits	281	Target Neighborhood Hits	872	Shared Neighborhood Hits	150
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG01_HUMAN
NC score	0.669119 (rank : 32)	θ value	3.64472e-09 (rank : 55)
Query Neighborhood Hits	281	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

BCR_HUMAN
NC score	0.668015 (rank : 33)	θ value	1.74391e-19 (rank : 18)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	80
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RHG08_MOUSE
NC score	0.652243 (rank : 34)	θ value	1.133e-10 (rank : 49)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RBP1_MOUSE
NC score	0.650580 (rank : 35)	θ value	1.52774e-15 (rank : 31)
Query Neighborhood Hits	281	Target Neighborhood Hits	493	Shared Neighborhood Hits	91
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG08_HUMAN
NC score	0.648029 (rank : 36)	θ value	3.89403e-11 (rank : 47)
Query Neighborhood Hits	281	Target Neighborhood Hits	88	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG25_MOUSE
NC score	0.639328 (rank : 37)	θ value	1.09485e-13 (rank : 37)
Query Neighborhood Hits	281	Target Neighborhood Hits	492	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RBP1_HUMAN
NC score	0.635142 (rank : 38)	θ value	2.20605e-14 (rank : 33)
Query Neighborhood Hits	281	Target Neighborhood Hits	521	Shared Neighborhood Hits	93
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG25_HUMAN
NC score	0.625215 (rank : 39)	θ value	4.91457e-14 (rank : 34)
Query Neighborhood Hits	281	Target Neighborhood Hits	550	Shared Neighborhood Hits	98
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CEND2_HUMAN
NC score	0.603843 (rank : 40)	θ value	2.13179e-17 (rank : 22)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

RHG07_MOUSE
NC score	0.595874 (rank : 41)	θ value	5.08577e-11 (rank : 48)
Query Neighborhood Hits	281	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
NC score	0.592193 (rank : 42)	θ value	1.02475e-11 (rank : 44)
Query Neighborhood Hits	281	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

TAGAP_HUMAN
NC score	0.581371 (rank : 43)	θ value	9.92553e-07 (rank : 64)
Query Neighborhood Hits	281	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.580592 (rank : 44)	θ value	9.29e-05 (rank : 80)
Query Neighborhood Hits	281	Target Neighborhood Hits	83	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

CE005_HUMAN
NC score	0.560228 (rank : 45)	θ value	9.59137e-10 (rank : 51)
Query Neighborhood Hits	281	Target Neighborhood Hits	213	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CEND3_MOUSE
NC score	0.558597 (rank : 46)	θ value	8.11959e-09 (rank : 56)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CE005_MOUSE
NC score	0.557128 (rank : 47)	θ value	7.34386e-10 (rank : 50)
Query Neighborhood Hits	281	Target Neighborhood Hits	238	Shared Neighborhood Hits	72
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

STAR8_MOUSE
NC score	0.556607 (rank : 48)	θ value	2.79066e-09 (rank : 54)
Query Neighborhood Hits	281	Target Neighborhood Hits	101	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
NC score	0.552719 (rank : 49)	θ value	1.63604e-09 (rank : 53)
Query Neighborhood Hits	281	Target Neighborhood Hits	216	Shared Neighborhood Hits	66
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_HUMAN
NC score	0.551703 (rank : 50)	θ value	2.36244e-08 (rank : 59)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

CEND3_HUMAN
NC score	0.549887 (rank : 51)	θ value	1.38499e-08 (rank : 57)
Query Neighborhood Hits	281	Target Neighborhood Hits	275	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

STA13_MOUSE
NC score	0.541627 (rank : 52)	θ value	1.53129e-07 (rank : 61)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CEND1_MOUSE
NC score	0.513584 (rank : 53)	θ value	2.36244e-08 (rank : 58)
Query Neighborhood Hits	281	Target Neighborhood Hits	260	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.493879 (rank : 54)	θ value	8.97725e-08 (rank : 60)
Query Neighborhood Hits	281	Target Neighborhood Hits	284	Shared Neighborhood Hits	69
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

K1688_MOUSE
NC score	0.460360 (rank : 55)	θ value	0.00228821 (rank : 107)
Query Neighborhood Hits	281	Target Neighborhood Hits	188	Shared Neighborhood Hits	66
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.445588 (rank : 56)	θ value	0.00509761 (rank : 120)
Query Neighborhood Hits	281	Target Neighborhood Hits	217	Shared Neighborhood Hits	61
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

P85A_HUMAN
NC score	0.413842 (rank : 57)	θ value	2.44474e-05 (rank : 68)
Query Neighborhood Hits	281	Target Neighborhood Hits	479	Shared Neighborhood Hits	149
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.407924 (rank : 58)	θ value	0.000158464 (rank : 84)
Query Neighborhood Hits	281	Target Neighborhood Hits	435	Shared Neighborhood Hits	150
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MYO9B_MOUSE
NC score	0.390243 (rank : 59)	θ value	3.63628e-17 (rank : 23)
Query Neighborhood Hits	281	Target Neighborhood Hits	311	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.385227 (rank : 60)	θ value	8.10077e-17 (rank : 25)
Query Neighborhood Hits	281	Target Neighborhood Hits	641	Shared Neighborhood Hits	84
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

DP13A_HUMAN
NC score	0.355526 (rank : 61)	θ value	1.16975e-15 (rank : 30)
Query Neighborhood Hits	281	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
NC score	0.353957 (rank : 62)	θ value	8.95645e-16 (rank : 29)
Query Neighborhood Hits	281	Target Neighborhood Hits	96	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_MOUSE
NC score	0.341619 (rank : 63)	θ value	6.41864e-14 (rank : 35)
Query Neighborhood Hits	281	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_HUMAN
NC score	0.333335 (rank : 64)	θ value	9.26847e-13 (rank : 40)
Query Neighborhood Hits	281	Target Neighborhood Hits	58	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CD2AP_HUMAN
NC score	0.327611 (rank : 65)	θ value	5.81887e-07 (rank : 62)
Query Neighborhood Hits	281	Target Neighborhood Hits	315	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.327322 (rank : 66)	θ value	5.81887e-07 (rank : 63)
Query Neighborhood Hits	281	Target Neighborhood Hits	336	Shared Neighborhood Hits	143
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.324209 (rank : 67)	θ value	4.1701e-05 (rank : 71)
Query Neighborhood Hits	281	Target Neighborhood Hits	332	Shared Neighborhood Hits	135
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.319980 (rank : 68)	θ value	5.44631e-05 (rank : 74)
Query Neighborhood Hits	281	Target Neighborhood Hits	341	Shared Neighborhood Hits	137
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ABI2_MOUSE
NC score	0.307972 (rank : 69)	θ value	0.000121331 (rank : 82)
Query Neighborhood Hits	281	Target Neighborhood Hits	266	Shared Neighborhood Hits	130
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

VINEX_MOUSE
NC score	0.304560 (rank : 70)	θ value	0.00134147 (rank : 105)
Query Neighborhood Hits	281	Target Neighborhood Hits	286	Shared Neighborhood Hits	144
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ABI2_HUMAN
NC score	0.303839 (rank : 71)	θ value	0.000121331 (rank : 81)
Query Neighborhood Hits	281	Target Neighborhood Hits	350	Shared Neighborhood Hits	132
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

VINEX_HUMAN
NC score	0.300714 (rank : 72)	θ value	0.0252991 (rank : 138)
Query Neighborhood Hits	281	Target Neighborhood Hits	270	Shared Neighborhood Hits	140
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABI1_MOUSE
NC score	0.298200 (rank : 73)	θ value	0.000602161 (rank : 87)
Query Neighborhood Hits	281	Target Neighborhood Hits	246	Shared Neighborhood Hits	127
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G2_MOUSE
NC score	0.292269 (rank : 74)	θ value	0.000786445 (rank : 96)
Query Neighborhood Hits	281	Target Neighborhood Hits	319	Shared Neighborhood Hits	143
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G2_HUMAN
NC score	0.290433 (rank : 75)	θ value	0.00228821 (rank : 109)
Query Neighborhood Hits	281	Target Neighborhood Hits	324	Shared Neighborhood Hits	147
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

HCLS1_HUMAN
NC score	0.289375 (rank : 76)	θ value	0.0148317 (rank : 127)
Query Neighborhood Hits	281	Target Neighborhood Hits	358	Shared Neighborhood Hits	128
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI1_HUMAN
NC score	0.288151 (rank : 77)	θ value	0.000786445 (rank : 93)
Query Neighborhood Hits	281	Target Neighborhood Hits	257	Shared Neighborhood Hits	127
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SRBS1_MOUSE
NC score	0.287535 (rank : 78)	θ value	0.125558 (rank : 158)
Query Neighborhood Hits	281	Target Neighborhood Hits	409	Shared Neighborhood Hits	147
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

HCLS1_MOUSE
NC score	0.287123 (rank : 79)	θ value	0.0330416 (rank : 141)
Query Neighborhood Hits	281	Target Neighborhood Hits	329	Shared Neighborhood Hits	132
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_HUMAN
NC score	0.286674 (rank : 80)	θ value	0.000602161 (rank : 92)
Query Neighborhood Hits	281	Target Neighborhood Hits	269	Shared Neighborhood Hits	136
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.286209 (rank : 81)	θ value	0.00390308 (rank : 119)
Query Neighborhood Hits	281	Target Neighborhood Hits	292	Shared Neighborhood Hits	134
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRBS1_HUMAN
NC score	0.285414 (rank : 82)	θ value	0.0736092 (rank : 149)
Query Neighborhood Hits	281	Target Neighborhood Hits	396	Shared Neighborhood Hits	148
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G3_MOUSE
NC score	0.279738 (rank : 83)	θ value	0.0113563 (rank : 125)
Query Neighborhood Hits	281	Target Neighborhood Hits	236	Shared Neighborhood Hits	136
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G1_HUMAN
NC score	0.277509 (rank : 84)	θ value	0.00102713 (rank : 100)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	148
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
NC score	0.276336 (rank : 85)	θ value	0.00390308 (rank : 117)
Query Neighborhood Hits	281	Target Neighborhood Hits	291	Shared Neighborhood Hits	144
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

GRB2_HUMAN
NC score	0.276225 (rank : 86)	θ value	9.29e-05 (rank : 78)
Query Neighborhood Hits	281	Target Neighborhood Hits	310	Shared Neighborhood Hits	138
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.276178 (rank : 87)	θ value	9.29e-05 (rank : 79)
Query Neighborhood Hits	281	Target Neighborhood Hits	312	Shared Neighborhood Hits	138
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SH3G3_HUMAN
NC score	0.276017 (rank : 88)	θ value	0.0252991 (rank : 137)
Query Neighborhood Hits	281	Target Neighborhood Hits	222	Shared Neighborhood Hits	137
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

PACN2_HUMAN
NC score	0.275886 (rank : 89)	θ value	7.1131e-05 (rank : 77)
Query Neighborhood Hits	281	Target Neighborhood Hits	339	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

NCF4_MOUSE
NC score	0.270997 (rank : 90)	θ value	0.0148317 (rank : 130)
Query Neighborhood Hits	281	Target Neighborhood Hits	177	Shared Neighborhood Hits	119
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN2_MOUSE
NC score	0.270420 (rank : 91)	θ value	0.000158464 (rank : 85)
Query Neighborhood Hits	281	Target Neighborhood Hits	382	Shared Neighborhood Hits	147
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CENB2_HUMAN
NC score	0.270112 (rank : 92)	θ value	6.18819e-25 (rank : 8)
Query Neighborhood Hits	281	Target Neighborhood Hits	425	Shared Neighborhood Hits	35
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

PACN1_MOUSE
NC score	0.269591 (rank : 93)	θ value	0.00102713 (rank : 98)
Query Neighborhood Hits	281	Target Neighborhood Hits	283	Shared Neighborhood Hits	142
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.269431 (rank : 94)	θ value	0.000602161 (rank : 90)
Query Neighborhood Hits	281	Target Neighborhood Hits	320	Shared Neighborhood Hits	150
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

NCF2_HUMAN
NC score	0.267634 (rank : 95)	θ value	0.47712 (rank : 181)
Query Neighborhood Hits	281	Target Neighborhood Hits	229	Shared Neighborhood Hits	120
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

GRAP2_MOUSE
NC score	0.264743 (rank : 96)	θ value	7.1131e-05 (rank : 76)
Query Neighborhood Hits	281	Target Neighborhood Hits	297	Shared Neighborhood Hits	137
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CENB5_HUMAN
NC score	0.264139 (rank : 97)	θ value	2.43343e-21 (rank : 14)
Query Neighborhood Hits	281	Target Neighborhood Hits	395	Shared Neighborhood Hits	31
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

GRAP2_HUMAN
NC score	0.262560 (rank : 98)	θ value	3.19293e-05 (rank : 69)
Query Neighborhood Hits	281	Target Neighborhood Hits	304	Shared Neighborhood Hits	138
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ABI3_HUMAN
NC score	0.261734 (rank : 99)	θ value	0.00298849 (rank : 112)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	113
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG7_MOUSE
NC score	0.259541 (rank : 100)	θ value	0.000786445 (rank : 94)
Query Neighborhood Hits	281	Target Neighborhood Hits	396	Shared Neighborhood Hits	142
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

PACN3_MOUSE
NC score	0.259454 (rank : 101)	θ value	0.00134147 (rank : 103)
Query Neighborhood Hits	281	Target Neighborhood Hits	380	Shared Neighborhood Hits	143
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

ABI3_MOUSE
NC score	0.258894 (rank : 102)	θ value	0.00390308 (rank : 116)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

GRAP_MOUSE
NC score	0.258607 (rank : 103)	θ value	0.0330416 (rank : 140)
Query Neighborhood Hits	281	Target Neighborhood Hits	309	Shared Neighborhood Hits	137
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

DDEF1_MOUSE
NC score	0.258336 (rank : 104)	θ value	0.163984 (rank : 160)
Query Neighborhood Hits	281	Target Neighborhood Hits	592	Shared Neighborhood Hits	129
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GRAP_HUMAN
NC score	0.256754 (rank : 105)	θ value	0.0330416 (rank : 139)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	133
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.256215 (rank : 106)	θ value	0.62314 (rank : 188)
Query Neighborhood Hits	281	Target Neighborhood Hits	310	Shared Neighborhood Hits	138
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

DNMBP_HUMAN
NC score	0.255886 (rank : 107)	θ value	2.44474e-05 (rank : 66)
Query Neighborhood Hits	281	Target Neighborhood Hits	413	Shared Neighborhood Hits	150
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DDEF2_HUMAN
NC score	0.255855 (rank : 108)	θ value	0.21417 (rank : 170)
Query Neighborhood Hits	281	Target Neighborhood Hits	599	Shared Neighborhood Hits	132
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.255387 (rank : 109)	θ value	0.21417 (rank : 171)
Query Neighborhood Hits	281	Target Neighborhood Hits	625	Shared Neighborhood Hits	129
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PPIP1_HUMAN
NC score	0.255255 (rank : 110)	θ value	0.0193708 (rank : 133)
Query Neighborhood Hits	281	Target Neighborhood Hits	389	Shared Neighborhood Hits	155
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PACN3_HUMAN
NC score	0.255201 (rank : 111)	θ value	0.00134147 (rank : 102)
Query Neighborhood Hits	281	Target Neighborhood Hits	385	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ARHG7_HUMAN
NC score	0.255179 (rank : 112)	θ value	7.1131e-05 (rank : 75)
Query Neighborhood Hits	281	Target Neighborhood Hits	347	Shared Neighborhood Hits	140
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

NCF4_HUMAN
NC score	0.254774 (rank : 113)	θ value	0.0961366 (rank : 153)
Query Neighborhood Hits	281	Target Neighborhood Hits	161	Shared Neighborhood Hits	108
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DNMBP_MOUSE
NC score	0.252694 (rank : 114)	θ value	5.44631e-05 (rank : 72)
Query Neighborhood Hits	281	Target Neighborhood Hits	435	Shared Neighborhood Hits	150
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCK1_HUMAN
NC score	0.251712 (rank : 115)	θ value	0.00134147 (rank : 101)
Query Neighborhood Hits	281	Target Neighborhood Hits	312	Shared Neighborhood Hits	135
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

OCRL_HUMAN
NC score	0.249449 (rank : 116)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	281	Target Neighborhood Hits	77	Shared Neighborhood Hits	50
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

I5P2_HUMAN
NC score	0.249299 (rank : 117)	θ value	5.27518 (rank : 246)
Query Neighborhood Hits	281	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

CENB1_HUMAN
NC score	0.248374 (rank : 118)	θ value	2.60593e-15 (rank : 32)
Query Neighborhood Hits	281	Target Neighborhood Hits	383	Shared Neighborhood Hits	31
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

STAM1_HUMAN
NC score	0.248134 (rank : 119)	θ value	0.00228821 (rank : 110)
Query Neighborhood Hits	281	Target Neighborhood Hits	271	Shared Neighborhood Hits	134
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PPIP1_MOUSE
NC score	0.247834 (rank : 120)	θ value	0.47712 (rank : 182)
Query Neighborhood Hits	281	Target Neighborhood Hits	377	Shared Neighborhood Hits	155
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

STAM1_MOUSE
NC score	0.247200 (rank : 121)	θ value	0.00228821 (rank : 111)
Query Neighborhood Hits	281	Target Neighborhood Hits	273	Shared Neighborhood Hits	132
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG6_MOUSE
NC score	0.246401 (rank : 122)	θ value	0.000602161 (rank : 89)
Query Neighborhood Hits	281	Target Neighborhood Hits	394	Shared Neighborhood Hits	143
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

STAM2_MOUSE
NC score	0.242603 (rank : 123)	θ value	0.0736092 (rank : 150)
Query Neighborhood Hits	281	Target Neighborhood Hits	285	Shared Neighborhood Hits	130
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ARHG6_HUMAN
NC score	0.241711 (rank : 124)	θ value	0.000602161 (rank : 88)
Query Neighborhood Hits	281	Target Neighborhood Hits	376	Shared Neighborhood Hits	141
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

STAM2_HUMAN
NC score	0.234674 (rank : 125)	θ value	0.279714 (rank : 177)
Query Neighborhood Hits	281	Target Neighborhood Hits	288	Shared Neighborhood Hits	131
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

LASP1_HUMAN
NC score	0.231956 (rank : 126)	θ value	0.00665767 (rank : 122)
Query Neighborhood Hits	281	Target Neighborhood Hits	293	Shared Neighborhood Hits	124
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.231257 (rank : 127)	θ value	0.00665767 (rank : 123)
Query Neighborhood Hits	281	Target Neighborhood Hits	297	Shared Neighborhood Hits	124
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NEBL_HUMAN
NC score	0.230504 (rank : 128)	θ value	2.44474e-05 (rank : 67)
Query Neighborhood Hits	281	Target Neighborhood Hits	457	Shared Neighborhood Hits	148
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

DBNL_HUMAN
NC score	0.226834 (rank : 129)	θ value	0.125558 (rank : 155)
Query Neighborhood Hits	281	Target Neighborhood Hits	244	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

STAC_HUMAN
NC score	0.222970 (rank : 130)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	281	Target Neighborhood Hits	276	Shared Neighborhood Hits	128
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

DBNL_MOUSE
NC score	0.222171 (rank : 131)	θ value	0.125558 (rank : 156)
Query Neighborhood Hits	281	Target Neighborhood Hits	306	Shared Neighborhood Hits	123
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

PEX13_MOUSE
NC score	0.222086 (rank : 132)	θ value	0.000602161 (rank : 91)
Query Neighborhood Hits	281	Target Neighborhood Hits	126	Shared Neighborhood Hits	95
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

STAC_MOUSE
NC score	0.221976 (rank : 133)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	281	Target Neighborhood Hits	268	Shared Neighborhood Hits	126
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PEX13_HUMAN
NC score	0.220001 (rank : 134)	θ value	0.00134147 (rank : 104)
Query Neighborhood Hits	281	Target Neighborhood Hits	128	Shared Neighborhood Hits	91
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ITSN2_HUMAN
NC score	0.219920 (rank : 135)	θ value	4.1701e-05 (rank : 70)
Query Neighborhood Hits	281	Target Neighborhood Hits	1173	Shared Neighborhood Hits	182
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

STAC3_MOUSE
NC score	0.218455 (rank : 136)	θ value	6.88961 (rank : 265)
Query Neighborhood Hits	281	Target Neighborhood Hits	232	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.217373 (rank : 137)	θ value	6.88961 (rank : 264)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	118
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CRKL_HUMAN
NC score	0.215155 (rank : 138)	θ value	6.88961 (rank : 256)
Query Neighborhood Hits	281	Target Neighborhood Hits	313	Shared Neighborhood Hits	135
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

VAV_MOUSE
NC score	0.213542 (rank : 139)	θ value	0.00298849 (rank : 115)
Query Neighborhood Hits	281	Target Neighborhood Hits	430	Shared Neighborhood Hits	146
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ITSN1_HUMAN
NC score	0.212940 (rank : 140)	θ value	0.000121331 (rank : 83)
Query Neighborhood Hits	281	Target Neighborhood Hits	1757	Shared Neighborhood Hits	192
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
NC score	0.212836 (rank : 141)	θ value	1.87187e-05 (rank : 65)
Query Neighborhood Hits	281	Target Neighborhood Hits	1371	Shared Neighborhood Hits	184
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

OSTF1_HUMAN
NC score	0.212718 (rank : 142)	θ value	0.0252991 (rank : 136)
Query Neighborhood Hits	281	Target Neighborhood Hits	466	Shared Neighborhood Hits	133
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.212709 (rank : 143)	θ value	0.0193708 (rank : 132)
Query Neighborhood Hits	281	Target Neighborhood Hits	467	Shared Neighborhood Hits	135
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ITSN1_MOUSE
NC score	0.211406 (rank : 144)	θ value	0.00035302 (rank : 86)
Query Neighborhood Hits	281	Target Neighborhood Hits	1669	Shared Neighborhood Hits	189
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VAV_HUMAN
NC score	0.211150 (rank : 145)	θ value	0.00298849 (rank : 114)
Query Neighborhood Hits	281	Target Neighborhood Hits	452	Shared Neighborhood Hits	148
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

NEBU_HUMAN
NC score	0.205989 (rank : 146)	θ value	0.000786445 (rank : 95)
Query Neighborhood Hits	281	Target Neighborhood Hits	420	Shared Neighborhood Hits	133
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

CRKL_MOUSE
NC score	0.205105 (rank : 147)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	131
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

VAV2_MOUSE
NC score	0.197679 (rank : 148)	θ value	8.99809 (rank : 281)
Query Neighborhood Hits	281	Target Neighborhood Hits	456	Shared Neighborhood Hits	142
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.197187 (rank : 149)	θ value	8.99809 (rank : 280)
Query Neighborhood Hits	281	Target Neighborhood Hits	453	Shared Neighborhood Hits	142
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
NC score	0.196506 (rank : 150)	θ value	1.81305 (rank : 217)
Query Neighborhood Hits	281	Target Neighborhood Hits	398	Shared Neighborhood Hits	138
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SNX18_MOUSE
NC score	0.195548 (rank : 151)	θ value	0.0736092 (rank : 148)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	112
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PLCG1_MOUSE
NC score	0.194275 (rank : 152)	θ value	0.00102713 (rank : 99)
Query Neighborhood Hits	281	Target Neighborhood Hits	314	Shared Neighborhood Hits	123
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SNX18_HUMAN
NC score	0.192913 (rank : 153)	θ value	0.163984 (rank : 168)
Query Neighborhood Hits	281	Target Neighborhood Hits	207	Shared Neighborhood Hits	115
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CT032_HUMAN
NC score	0.192301 (rank : 154)	θ value	0.62314 (rank : 185)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	109
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

VAV3_MOUSE
NC score	0.192278 (rank : 155)	θ value	4.03905 (rank : 241)
Query Neighborhood Hits	281	Target Neighborhood Hits	404	Shared Neighborhood Hits	135
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

CRK_MOUSE
NC score	0.191475 (rank : 156)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	281	Target Neighborhood Hits	314	Shared Neighborhood Hits	130
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCF1_MOUSE
NC score	0.191025 (rank : 157)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	121
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PLCG1_HUMAN
NC score	0.189168 (rank : 158)	θ value	0.00228821 (rank : 108)
Query Neighborhood Hits	281	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CRK_HUMAN
NC score	0.188071 (rank : 159)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	281	Target Neighborhood Hits	308	Shared Neighborhood Hits	130
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PLCG2_HUMAN
NC score	0.188019 (rank : 160)	θ value	0.00298849 (rank : 113)
Query Neighborhood Hits	281	Target Neighborhood Hits	280	Shared Neighborhood Hits	115
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

EFS_HUMAN
NC score	0.187506 (rank : 161)	θ value	0.21417 (rank : 172)
Query Neighborhood Hits	281	Target Neighborhood Hits	348	Shared Neighborhood Hits	115
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
NC score	0.186975 (rank : 162)	θ value	0.21417 (rank : 173)
Query Neighborhood Hits	281	Target Neighborhood Hits	389	Shared Neighborhood Hits	118
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

BCAR1_MOUSE
NC score	0.185702 (rank : 163)	θ value	0.21417 (rank : 169)
Query Neighborhood Hits	281	Target Neighborhood Hits	438	Shared Neighborhood Hits	125
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NCF1_HUMAN
NC score	0.184639 (rank : 164)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	111
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NPHP1_MOUSE
NC score	0.177110 (rank : 165)	θ value	2.36792 (rank : 221)
Query Neighborhood Hits	281	Target Neighborhood Hits	267	Shared Neighborhood Hits	116
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

BCAR1_HUMAN
NC score	0.176418 (rank : 166)	θ value	0.163984 (rank : 159)
Query Neighborhood Hits	281	Target Neighborhood Hits	554	Shared Neighborhood Hits	124
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

RIMB2_MOUSE
NC score	0.173101 (rank : 167)	θ value	0.0431538 (rank : 143)
Query Neighborhood Hits	281	Target Neighborhood Hits	246	Shared Neighborhood Hits	100
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_HUMAN
NC score	0.168514 (rank : 168)	θ value	0.163984 (rank : 167)
Query Neighborhood Hits	281	Target Neighborhood Hits	263	Shared Neighborhood Hits	101
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

P85B_HUMAN
NC score	0.160842 (rank : 169)	θ value	0.0330416 (rank : 142)
Query Neighborhood Hits	281	Target Neighborhood Hits	543	Shared Neighborhood Hits	102
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ARHG4_HUMAN
NC score	0.160809 (rank : 170)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	281	Target Neighborhood Hits	242	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NPHP1_HUMAN
NC score	0.158367 (rank : 171)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	281	Target Neighborhood Hits	288	Shared Neighborhood Hits	114
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

CASL_HUMAN
NC score	0.157950 (rank : 172)	θ value	1.81305 (rank : 208)
Query Neighborhood Hits	281	Target Neighborhood Hits	259	Shared Neighborhood Hits	114
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

SNX9_HUMAN
NC score	0.157946 (rank : 173)	θ value	0.00390308 (rank : 118)
Query Neighborhood Hits	281	Target Neighborhood Hits	148	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

CASL_MOUSE
NC score	0.156771 (rank : 174)	θ value	1.81305 (rank : 209)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	112
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

AHI1_HUMAN
NC score	0.155516 (rank : 175)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	281	Target Neighborhood Hits	537	Shared Neighborhood Hits	136
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.154735 (rank : 176)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	281	Target Neighborhood Hits	496	Shared Neighborhood Hits	133
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

DDFL1_HUMAN
NC score	0.153959 (rank : 177)	θ value	0.00228821 (rank : 106)
Query Neighborhood Hits	281	Target Neighborhood Hits	353	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

SNX9_MOUSE
NC score	0.152016 (rank : 178)	θ value	0.000786445 (rank : 97)
Query Neighborhood Hits	281	Target Neighborhood Hits	141	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

MYO1F_HUMAN
NC score	0.151201 (rank : 179)	θ value	0.0148317 (rank : 129)
Query Neighborhood Hits	281	Target Neighborhood Hits	275	Shared Neighborhood Hits	129
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.150256 (rank : 180)	θ value	0.0193708 (rank : 131)
Query Neighborhood Hits	281	Target Neighborhood Hits	262	Shared Neighborhood Hits	130
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ARHG9_MOUSE
NC score	0.149996 (rank : 181)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	281	Target Neighborhood Hits	234	Shared Neighborhood Hits	112
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.149829 (rank : 182)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	112
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

SHLB2_HUMAN
NC score	0.148927 (rank : 183)	θ value	0.0193708 (rank : 134)
Query Neighborhood Hits	281	Target Neighborhood Hits	86	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
NC score	0.148334 (rank : 184)	θ value	0.0193708 (rank : 135)
Query Neighborhood Hits	281	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB1_MOUSE
NC score	0.147300 (rank : 185)	θ value	0.62314 (rank : 191)
Query Neighborhood Hits	281	Target Neighborhood Hits	101	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

MYO1E_HUMAN
NC score	0.147115 (rank : 186)	θ value	5.44631e-05 (rank : 73)
Query Neighborhood Hits	281	Target Neighborhood Hits	293	Shared Neighborhood Hits	130
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SHLB1_HUMAN
NC score	0.143945 (rank : 187)	θ value	0.62314 (rank : 190)
Query Neighborhood Hits	281	Target Neighborhood Hits	96	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

DDFL1_MOUSE
NC score	0.135643 (rank : 188)	θ value	1.81305 (rank : 211)
Query Neighborhood Hits	281	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

IASPP_HUMAN
NC score	0.134195 (rank : 189)	θ value	3.0926 (rank : 227)
Query Neighborhood Hits	281	Target Neighborhood Hits	688	Shared Neighborhood Hits	123
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

RUSC1_HUMAN
NC score	0.130943 (rank : 190)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	281	Target Neighborhood Hits	226	Shared Neighborhood Hits	100
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

NOXO1_MOUSE
NC score	0.128046 (rank : 191)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	281	Target Neighborhood Hits	114	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

P85B_MOUSE
NC score	0.127395 (rank : 192)	θ value	6.88961 (rank : 262)
Query Neighborhood Hits	281	Target Neighborhood Hits	519	Shared Neighborhood Hits	98
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

IASPP_MOUSE
NC score	0.126982 (rank : 193)	θ value	2.36792 (rank : 219)
Query Neighborhood Hits	281	Target Neighborhood Hits	1024	Shared Neighborhood Hits	131
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DAPP1_MOUSE
NC score	0.121964 (rank : 194)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ARHG4_MOUSE
NC score	0.121815 (rank : 195)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RUSC1_MOUSE
NC score	0.119964 (rank : 196)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	281	Target Neighborhood Hits	206	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

DAPP1_HUMAN
NC score	0.118296 (rank : 197)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ASPP1_HUMAN
NC score	0.114678 (rank : 198)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	281	Target Neighborhood Hits	956	Shared Neighborhood Hits	155
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CIP4_HUMAN
NC score	0.114058 (rank : 199)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	281	Target Neighborhood Hits	374	Shared Neighborhood Hits	81
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

ASPP1_MOUSE
NC score	0.113569 (rank : 200)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	281	Target Neighborhood Hits	1244	Shared Neighborhood Hits	157
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ANM2_HUMAN
NC score	0.112112 (rank : 201)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	281	Target Neighborhood Hits	175	Shared Neighborhood Hits	103
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RIMB1_HUMAN
NC score	0.111423 (rank : 202)	θ value	0.163984 (rank : 165)
Query Neighborhood Hits	281	Target Neighborhood Hits	1479	Shared Neighborhood Hits	147
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ANM2_MOUSE
NC score	0.109899 (rank : 203)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	281	Target Neighborhood Hits	175	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SPN90_HUMAN
NC score	0.109476 (rank : 204)	θ value	1.81305 (rank : 216)
Query Neighborhood Hits	281	Target Neighborhood Hits	157	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SMP1L_HUMAN
NC score	0.107007 (rank : 205)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	281	Target Neighborhood Hits	74	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMAP1_MOUSE
NC score	0.106986 (rank : 206)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_MOUSE
NC score	0.106180 (rank : 207)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	281	Target Neighborhood Hits	70	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CENA1_HUMAN
NC score	0.105431 (rank : 208)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	281	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

RIMB1_MOUSE
NC score	0.105422 (rank : 209)	θ value	0.163984 (rank : 166)
Query Neighborhood Hits	281	Target Neighborhood Hits	1376	Shared Neighborhood Hits	152
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SMAP1_HUMAN
NC score	0.104885 (rank : 210)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CENA2_HUMAN
NC score	0.104192 (rank : 211)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	281	Target Neighborhood Hits	83	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ES8L3_MOUSE
NC score	0.101485 (rank : 212)	θ value	1.81305 (rank : 212)
Query Neighborhood Hits	281	Target Neighborhood Hits	168	Shared Neighborhood Hits	97
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

P55G_HUMAN
NC score	0.101133 (rank : 213)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	281	Target Neighborhood Hits	451	Shared Neighborhood Hits	66
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CENA2_MOUSE
NC score	0.099180 (rank : 214)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	281	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

ARFG1_MOUSE
NC score	0.099022 (rank : 215)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	281	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

SPTA2_HUMAN
NC score	0.098942 (rank : 216)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	281	Target Neighborhood Hits	888	Shared Neighborhood Hits	158
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ARFG3_HUMAN
NC score	0.097660 (rank : 217)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	281	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

P55G_MOUSE
NC score	0.097133 (rank : 218)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	281	Target Neighborhood Hits	401	Shared Neighborhood Hits	60
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

ARFG3_MOUSE
NC score	0.096860 (rank : 219)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	281	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

BAIP2_HUMAN
NC score	0.096426 (rank : 220)	θ value	0.0736092 (rank : 146)
Query Neighborhood Hits	281	Target Neighborhood Hits	192	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

SPN90_MOUSE
NC score	0.096392 (rank : 221)	θ value	3.0926 (rank : 230)
Query Neighborhood Hits	281	Target Neighborhood Hits	157	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

BI2L1_HUMAN
NC score	0.095860 (rank : 222)	θ value	0.813845 (rank : 193)
Query Neighborhood Hits	281	Target Neighborhood Hits	156	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ASPP2_HUMAN
NC score	0.095653 (rank : 223)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	281	Target Neighborhood Hits	1156	Shared Neighborhood Hits	144
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ARHG5_HUMAN
NC score	0.095584 (rank : 224)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	281	Target Neighborhood Hits	172	Shared Neighborhood Hits	73
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

BAIP2_MOUSE
NC score	0.094926 (rank : 225)	θ value	0.365318 (rank : 178)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

ARFG1_HUMAN
NC score	0.094748 (rank : 226)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	281	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

SPTA1_MOUSE
NC score	0.089476 (rank : 227)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	281	Target Neighborhood Hits	675	Shared Neighborhood Hits	146
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

GRP3_HUMAN
NC score	0.088741 (rank : 228)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	281	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

CENG1_MOUSE
NC score	0.088620 (rank : 229)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	281	Target Neighborhood Hits	531	Shared Neighborhood Hits	21
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

SPTA1_HUMAN
NC score	0.087238 (rank : 230)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	281	Target Neighborhood Hits	748	Shared Neighborhood Hits	156
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

STS2_HUMAN
NC score	0.086456 (rank : 231)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	281	Target Neighborhood Hits	108	Shared Neighborhood Hits	67
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

STS1_MOUSE
NC score	0.086194 (rank : 232)	θ value	4.03905 (rank : 239)
Query Neighborhood Hits	281	Target Neighborhood Hits	104	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

CENG1_HUMAN
NC score	0.085989 (rank : 233)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	281	Target Neighborhood Hits	544	Shared Neighborhood Hits	19
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

STS1_HUMAN
NC score	0.084539 (rank : 234)	θ value	5.27518 (rank : 254)
Query Neighborhood Hits	281	Target Neighborhood Hits	106	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

RASA1_HUMAN
NC score	0.083770 (rank : 235)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	281	Target Neighborhood Hits	258	Shared Neighborhood Hits	52
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

NGEF_MOUSE
NC score	0.083023 (rank : 236)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	73
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
NC score	0.082457 (rank : 237)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ES8L3_HUMAN
NC score	0.081130 (rank : 238)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	281	Target Neighborhood Hits	206	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

BI2L1_MOUSE
NC score	0.081110 (rank : 239)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	281	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CENG3_MOUSE
NC score	0.080825 (rank : 240)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	281	Target Neighborhood Hits	467	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

NOXO1_HUMAN
NC score	0.080718 (rank : 241)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	281	Target Neighborhood Hits	100	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SHAN2_MOUSE
NC score	0.080243 (rank : 242)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	281	Target Neighborhood Hits	446	Shared Neighborhood Hits	87
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLAP2_MOUSE
NC score	0.079324 (rank : 243)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	281	Target Neighborhood Hits	136	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

CENG3_HUMAN
NC score	0.079257 (rank : 244)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	281	Target Neighborhood Hits	455	Shared Neighborhood Hits	15
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

SLAP1_MOUSE
NC score	0.078083 (rank : 245)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	281	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

ARHGA_HUMAN
NC score	0.076784 (rank : 246)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	281	Target Neighborhood Hits	187	Shared Neighborhood Hits	25
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_MOUSE
NC score	0.076449 (rank : 247)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	281	Target Neighborhood Hits	152	Shared Neighborhood Hits	50
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGA_MOUSE
NC score	0.075806 (rank : 248)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	281	Target Neighborhood Hits	125	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SLAP1_HUMAN
NC score	0.075252 (rank : 249)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	281	Target Neighborhood Hits	113	Shared Neighborhood Hits	34
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

PREX1_HUMAN
NC score	0.074767 (rank : 250)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	281	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SLAP2_HUMAN
NC score	0.074214 (rank : 251)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	281	Target Neighborhood Hits	139	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

TIAM1_HUMAN
NC score	0.074172 (rank : 252)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CENG2_MOUSE
NC score	0.073238 (rank : 253)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	281	Target Neighborhood Hits	463	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

TIAM1_MOUSE
NC score	0.073164 (rank : 254)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	281	Target Neighborhood Hits	205	Shared Neighborhood Hits	22
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CENG2_HUMAN
NC score	0.073151 (rank : 255)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	281	Target Neighborhood Hits	471	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

GIT1_HUMAN
NC score	0.072787 (rank : 256)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	281	Target Neighborhood Hits	336	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT2_HUMAN
NC score	0.072519 (rank : 257)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	281	Target Neighborhood Hits	381	Shared Neighborhood Hits	21
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
NC score	0.072517 (rank : 258)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	281	Target Neighborhood Hits	323	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

PKHG1_HUMAN
NC score	0.072352 (rank : 259)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	281	Target Neighborhood Hits	174	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ES8L2_HUMAN
NC score	0.072351 (rank : 260)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	281	Target Neighborhood Hits	193	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ARHG8_MOUSE
NC score	0.072116 (rank : 261)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	281	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

GIT1_MOUSE
NC score	0.072039 (rank : 262)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	281	Target Neighborhood Hits	341	Shared Neighborhood Hits	20
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

PKHA1_HUMAN
NC score	0.071887 (rank : 263)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	281	Target Neighborhood Hits	127	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ARHG3_HUMAN
NC score	0.071396 (rank : 264)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	281	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.071060 (rank : 265)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

SHAN1_HUMAN
NC score	0.070975 (rank : 266)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	281	Target Neighborhood Hits	1041	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EPS8_MOUSE
NC score	0.070232 (rank : 267)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	281	Target Neighborhood Hits	157	Shared Neighborhood Hits	85
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L2_MOUSE
NC score	0.070049 (rank : 268)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	281	Target Neighborhood Hits	169	Shared Neighborhood Hits	85
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MYO10_HUMAN
NC score	0.069054 (rank : 269)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	281	Target Neighborhood Hits	920	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

AMPH_HUMAN
NC score	0.069011 (rank : 270)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	281	Target Neighborhood Hits	455	Shared Neighborhood Hits	78
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

FGR_HUMAN
NC score	0.068989 (rank : 271)	θ value	0.0563607 (rank : 145)
Query Neighborhood Hits	281	Target Neighborhood Hits	1067	Shared Neighborhood Hits	138
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ECT2_MOUSE
NC score	0.068176 (rank : 272)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

GNRP_HUMAN
NC score	0.067789 (rank : 273)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	281	Target Neighborhood Hits	239	Shared Neighborhood Hits	31
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ECT2_HUMAN
NC score	0.067251 (rank : 274)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

BIN1_MOUSE
NC score	0.066859 (rank : 275)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	281	Target Neighborhood Hits	283	Shared Neighborhood Hits	69
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

EPS8_HUMAN
NC score	0.065991 (rank : 276)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	281	Target Neighborhood Hits	151	Shared Neighborhood Hits	74
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

PKHA1_MOUSE
NC score	0.065908 (rank : 277)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

FYN_MOUSE
NC score	0.065583 (rank : 278)	θ value	0.163984 (rank : 162)
Query Neighborhood Hits	281	Target Neighborhood Hits	1073	Shared Neighborhood Hits	138
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SH21A_HUMAN
NC score	0.065270 (rank : 279)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

ARHG8_HUMAN
NC score	0.065033 (rank : 280)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
NC score	0.064992 (rank : 281)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	281	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DOCK1_HUMAN
NC score	0.064979 (rank : 282)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	281	Target Neighborhood Hits	191	Shared Neighborhood Hits	91
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

GNRP_MOUSE
NC score	0.064590 (rank : 283)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	281	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SH21A_MOUSE
NC score	0.063865 (rank : 284)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	23
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

FYN_HUMAN
NC score	0.063845 (rank : 285)	θ value	0.163984 (rank : 161)
Query Neighborhood Hits	281	Target Neighborhood Hits	1078	Shared Neighborhood Hits	138
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

YES_MOUSE
NC score	0.063064 (rank : 286)	θ value	1.06291 (rank : 202)
Query Neighborhood Hits	281	Target Neighborhood Hits	1052	Shared Neighborhood Hits	136
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
NC score	0.062983 (rank : 287)	θ value	4.03905 (rank : 235)
Query Neighborhood Hits	281	Target Neighborhood Hits	1069	Shared Neighborhood Hits	136
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_HUMAN
NC score	0.062976 (rank : 288)	θ value	0.21417 (rank : 175)
Query Neighborhood Hits	281	Target Neighborhood Hits	1058	Shared Neighborhood Hits	142
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

BIN1_HUMAN
NC score	0.062696 (rank : 289)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	281	Target Neighborhood Hits	335	Shared Neighborhood Hits	69
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

AMPH_MOUSE
NC score	0.062574 (rank : 290)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	281	Target Neighborhood Hits	291	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

SH21B_MOUSE
NC score	0.062213 (rank : 291)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	281	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

YES_HUMAN
NC score	0.061553 (rank : 292)	θ value	1.38821 (rank : 207)
Query Neighborhood Hits	281	Target Neighborhood Hits	1059	Shared Neighborhood Hits	136
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGD4_MOUSE
NC score	0.061268 (rank : 293)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ES8L1_MOUSE
NC score	0.060052 (rank : 294)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	281	Target Neighborhood Hits	143	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

MY18A_HUMAN
NC score	0.060013 (rank : 295)	θ value	0.0961366 (rank : 152)
Query Neighborhood Hits	281	Target Neighborhood Hits	1929	Shared Neighborhood Hits	88
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

UN13A_HUMAN
NC score	0.059896 (rank : 296)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	281	Target Neighborhood Hits	285	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

CT2NL_HUMAN
NC score	0.059745 (rank : 297)	θ value	0.00665767 (rank : 121)
Query Neighborhood Hits	281	Target Neighborhood Hits	1059	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

PDZD8_HUMAN
NC score	0.059442 (rank : 298)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

MY18A_MOUSE
NC score	0.059282 (rank : 299)	θ value	0.163984 (rank : 164)
Query Neighborhood Hits	281	Target Neighborhood Hits	1989	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SHD_MOUSE
NC score	0.058922 (rank : 300)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	281	Target Neighborhood Hits	137	Shared Neighborhood Hits	38
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ES8L1_HUMAN
NC score	0.058562 (rank : 301)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	281	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

DGKH_HUMAN
NC score	0.058530 (rank : 302)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	281	Target Neighborhood Hits	255	Shared Neighborhood Hits	33
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PKHA6_MOUSE
NC score	0.058529 (rank : 303)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	281	Target Neighborhood Hits	591	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

NUPL_HUMAN
NC score	0.058406 (rank : 304)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	281	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

UN13B_HUMAN
NC score	0.058137 (rank : 305)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	281	Target Neighborhood Hits	217	Shared Neighborhood Hits	25
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

MCF2_HUMAN
NC score	0.058106 (rank : 306)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	26
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

SH21B_HUMAN
NC score	0.057826 (rank : 307)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	281	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

APS_HUMAN
NC score	0.057408 (rank : 308)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	281	Target Neighborhood Hits	162	Shared Neighborhood Hits	34
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

NUPL_MOUSE
NC score	0.057313 (rank : 309)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	281	Target Neighborhood Hits	113	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

FGD4_HUMAN
NC score	0.056993 (rank : 310)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	281	Target Neighborhood Hits	219	Shared Neighborhood Hits	33
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FA13A_HUMAN
NC score	0.056952 (rank : 311)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	281	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

RGNEF_MOUSE
NC score	0.056511 (rank : 312)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	281	Target Neighborhood Hits	641	Shared Neighborhood Hits	54
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

PKHA6_HUMAN
NC score	0.056461 (rank : 313)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	281	Target Neighborhood Hits	556	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

M3KL4_HUMAN
NC score	0.056417 (rank : 314)	θ value	3.0926 (rank : 228)
Query Neighborhood Hits	281	Target Neighborhood Hits	1087	Shared Neighborhood Hits	138
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

UN13B_MOUSE
NC score	0.056199 (rank : 315)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	281	Target Neighborhood Hits	210	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

FA13A_MOUSE
NC score	0.055997 (rank : 316)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	281	Target Neighborhood Hits	83	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

SLY_MOUSE
NC score	0.055945 (rank : 317)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	281	Target Neighborhood Hits	108	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

PPIP2_HUMAN
NC score	0.055748 (rank : 318)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	281	Target Neighborhood Hits	254	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

SHC1_MOUSE
NC score	0.055396 (rank : 319)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	281	Target Neighborhood Hits	180	Shared Neighborhood Hits	39
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

PPIP2_MOUSE
NC score	0.055162 (rank : 320)	θ value	8.99809 (rank : 274)
Query Neighborhood Hits	281	Target Neighborhood Hits	308	Shared Neighborhood Hits	35
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

SHB_HUMAN
NC score	0.054971 (rank : 321)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	281	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

MCF2L_MOUSE
NC score	0.054804 (rank : 322)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	281	Target Neighborhood Hits	255	Shared Neighborhood Hits	38
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

BTK_HUMAN
NC score	0.054692 (rank : 323)	θ value	0.0563607 (rank : 144)
Query Neighborhood Hits	281	Target Neighborhood Hits	1026	Shared Neighborhood Hits	135
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SHB_MOUSE
NC score	0.054606 (rank : 324)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	281	Target Neighborhood Hits	137	Shared Neighborhood Hits	35
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

HRBL_MOUSE
NC score	0.054368 (rank : 325)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	281	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_HUMAN
NC score	0.054083 (rank : 326)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	281	Target Neighborhood Hits	179	Shared Neighborhood Hits	15
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

MYH3_HUMAN
NC score	0.053450 (rank : 327)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	281	Target Neighborhood Hits	1660	Shared Neighborhood Hits	94
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYO5A_MOUSE
NC score	0.053312 (rank : 328)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	281	Target Neighborhood Hits	1117	Shared Neighborhood Hits	62
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5C_HUMAN
NC score	0.053261 (rank : 329)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	281	Target Neighborhood Hits	1206	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYH8_HUMAN
NC score	0.053112 (rank : 330)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	281	Target Neighborhood Hits	1610	Shared Neighborhood Hits	90
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SHC2_MOUSE
NC score	0.052975 (rank : 331)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	281	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

MYH8_MOUSE
NC score	0.052649 (rank : 332)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	281	Target Neighborhood Hits	1600	Shared Neighborhood Hits	87
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

PCTL_MOUSE
NC score	0.052631 (rank : 333)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	281	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

BTK_MOUSE
NC score	0.052576 (rank : 334)	θ value	0.0736092 (rank : 147)
Query Neighborhood Hits	281	Target Neighborhood Hits	1017	Shared Neighborhood Hits	130
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

MYO5A_HUMAN
NC score	0.052576 (rank : 335)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	281	Target Neighborhood Hits	1092	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

FGD1_HUMAN
NC score	0.052501 (rank : 336)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	281	Target Neighborhood Hits	367	Shared Neighborhood Hits	33
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MYO7A_MOUSE
NC score	0.052270 (rank : 337)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	35
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO15_MOUSE
NC score	0.052116 (rank : 338)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	281	Target Neighborhood Hits	467	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYH11_HUMAN
NC score	0.052056 (rank : 339)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	281	Target Neighborhood Hits	1806	Shared Neighborhood Hits	99
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PCTL_HUMAN
NC score	0.052047 (rank : 340)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	281	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

MYH11_MOUSE
NC score	0.052040 (rank : 341)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	281	Target Neighborhood Hits	1777	Shared Neighborhood Hits	95
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PICK1_MOUSE
NC score	0.052002 (rank : 342)	θ value	0.0113563 (rank : 124)
Query Neighborhood Hits	281	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SHD_HUMAN
NC score	0.051895 (rank : 343)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	35
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

PKHA4_HUMAN
NC score	0.051674 (rank : 344)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	281	Target Neighborhood Hits	283	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

MYH9_MOUSE
NC score	0.051672 (rank : 345)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	281	Target Neighborhood Hits	1829	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH1_MOUSE
NC score	0.051636 (rank : 346)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	281	Target Neighborhood Hits	1461	Shared Neighborhood Hits	89
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

TCRG1_MOUSE
NC score	0.051627 (rank : 347)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	281	Target Neighborhood Hits	947	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TCRG1_HUMAN
NC score	0.051474 (rank : 348)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	281	Target Neighborhood Hits	929	Shared Neighborhood Hits	50
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

DGKD_HUMAN
NC score	0.051447 (rank : 349)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	281	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

MYO6_HUMAN
NC score	0.051217 (rank : 350)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	281	Target Neighborhood Hits	727	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYH9_HUMAN
NC score	0.051164 (rank : 351)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	281	Target Neighborhood Hits	1762	Shared Neighborhood Hits	88
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

M3K9_HUMAN
NC score	0.051134 (rank : 352)	θ value	1.06291 (rank : 198)
Query Neighborhood Hits	281	Target Neighborhood Hits	1123	Shared Neighborhood Hits	129
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

GRB14_HUMAN
NC score	0.051097 (rank : 353)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	281	Target Neighborhood Hits	137	Shared Neighborhood Hits	35
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

PKHA2_MOUSE
NC score	0.051054 (rank : 354)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	281	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

MYO5B_HUMAN
NC score	0.050886 (rank : 355)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	281	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

SHC1_HUMAN
NC score	0.050770 (rank : 356)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	281	Target Neighborhood Hits	170	Shared Neighborhood Hits	38
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
NC score	0.050600 (rank : 357)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	281	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

FGD2_HUMAN
NC score	0.050502 (rank : 358)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	281	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD3_MOUSE
NC score	0.050489 (rank : 359)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	281	Target Neighborhood Hits	257	Shared Neighborhood Hits	22
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

MYH2_HUMAN
NC score	0.050454 (rank : 360)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	281	Target Neighborhood Hits	1491	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH1_HUMAN
NC score	0.050419 (rank : 361)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	281	Target Neighborhood Hits	1478	Shared Neighborhood Hits	86
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYO7A_HUMAN
NC score	0.050383 (rank : 362)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	281	Target Neighborhood Hits	209	Shared Neighborhood Hits	31
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

PKHA4_MOUSE
NC score	0.050334 (rank : 363)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	281	Target Neighborhood Hits	202	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

M3K11_HUMAN
NC score	0.050003 (rank : 364)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	281	Target Neighborhood Hits	1136	Shared Neighborhood Hits	130
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RAD50_MOUSE
NC score	0.047973 (rank : 365)	θ value	0.21417 (rank : 174)
Query Neighborhood Hits	281	Target Neighborhood Hits	1366	Shared Neighborhood Hits	74
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

GCC2_HUMAN
NC score	0.045282 (rank : 366)	θ value	1.06291 (rank : 197)
Query Neighborhood Hits	281	Target Neighborhood Hits	1558	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
NC score	0.045213 (rank : 367)	θ value	1.06291 (rank : 199)
Query Neighborhood Hits	281	Target Neighborhood Hits	1559	Shared Neighborhood Hits	87
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

CSK_MOUSE
NC score	0.044835 (rank : 368)	θ value	5.27518 (rank : 244)
Query Neighborhood Hits	281	Target Neighborhood Hits	1009	Shared Neighborhood Hits	109
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.044763 (rank : 369)	θ value	5.27518 (rank : 243)
Query Neighborhood Hits	281	Target Neighborhood Hits	1009	Shared Neighborhood Hits	109
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

SYCP1_MOUSE
NC score	0.044503 (rank : 370)	θ value	0.47712 (rank : 183)
Query Neighborhood Hits	281	Target Neighborhood Hits	1456	Shared Neighborhood Hits	75
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

GOGA4_HUMAN
NC score	0.043992 (rank : 371)	θ value	0.279714 (rank : 176)
Query Neighborhood Hits	281	Target Neighborhood Hits	2034	Shared Neighborhood Hits	92
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

PICK1_HUMAN
NC score	0.042972 (rank : 372)	θ value	0.125558 (rank : 157)
Query Neighborhood Hits	281	Target Neighborhood Hits	132	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

TARA_MOUSE
NC score	0.042738 (rank : 373)	θ value	4.03905 (rank : 240)
Query Neighborhood Hits	281	Target Neighborhood Hits	1133	Shared Neighborhood Hits	59
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

AKA11_HUMAN
NC score	0.041430 (rank : 374)	θ value	0.125558 (rank : 154)
Query Neighborhood Hits	281	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKA4, O75124, Q9NUK7	Gene names	AKAP11, AKAP220, KIAA0629
Domain Architecture
Description	A-kinase anchor protein 11 (Protein kinase A-anchoring protein 11) (PRKA11) (A kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220).

CCD46_MOUSE
NC score	0.041356 (rank : 375)	θ value	8.99809 (rank : 268)
Query Neighborhood Hits	281	Target Neighborhood Hits	1405	Shared Neighborhood Hits	78
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

GCC2_MOUSE
NC score	0.039836 (rank : 376)	θ value	0.163984 (rank : 163)
Query Neighborhood Hits	281	Target Neighborhood Hits	1619	Shared Neighborhood Hits	76
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GOGA4_MOUSE
NC score	0.039577 (rank : 377)	θ value	1.81305 (rank : 214)
Query Neighborhood Hits	281	Target Neighborhood Hits	1939	Shared Neighborhood Hits	88
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

SM1L2_MOUSE
NC score	0.039467 (rank : 378)	θ value	0.365318 (rank : 179)
Query Neighborhood Hits	281	Target Neighborhood Hits	918	Shared Neighborhood Hits	59
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

CP250_HUMAN
NC score	0.038639 (rank : 379)	θ value	6.88961 (rank : 255)
Query Neighborhood Hits	281	Target Neighborhood Hits	1805	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CK5P2_HUMAN
NC score	0.038584 (rank : 380)	θ value	4.03905 (rank : 233)
Query Neighborhood Hits	281	Target Neighborhood Hits	1433	Shared Neighborhood Hits	75
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CCD39_MOUSE
NC score	0.038205 (rank : 381)	θ value	0.0148317 (rank : 126)
Query Neighborhood Hits	281	Target Neighborhood Hits	1026	Shared Neighborhood Hits	52
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

SAS6_MOUSE
NC score	0.037764 (rank : 382)	θ value	1.06291 (rank : 200)
Query Neighborhood Hits	281	Target Neighborhood Hits	931	Shared Neighborhood Hits	57
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

SAS6_HUMAN
NC score	0.037397 (rank : 383)	θ value	0.813845 (rank : 194)
Query Neighborhood Hits	281	Target Neighborhood Hits	791	Shared Neighborhood Hits	50
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

SMC2_HUMAN
NC score	0.035953 (rank : 384)	θ value	5.27518 (rank : 253)
Query Neighborhood Hits	281	Target Neighborhood Hits	1405	Shared Neighborhood Hits	76
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

HIP1_HUMAN
NC score	0.035858 (rank : 385)	θ value	0.0148317 (rank : 128)
Query Neighborhood Hits	281	Target Neighborhood Hits	1016	Shared Neighborhood Hits	52
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

TPR_HUMAN
NC score	0.035771 (rank : 386)	θ value	8.99809 (rank : 278)
Query Neighborhood Hits	281	Target Neighborhood Hits	1921	Shared Neighborhood Hits	83
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

PTK6_HUMAN
NC score	0.035700 (rank : 387)	θ value	4.03905 (rank : 238)
Query Neighborhood Hits	281	Target Neighborhood Hits	1020	Shared Neighborhood Hits	116
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

MDC1_HUMAN
NC score	0.033508 (rank : 388)	θ value	0.47712 (rank : 180)
Query Neighborhood Hits	281	Target Neighborhood Hits	1446	Shared Neighborhood Hits	59
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CCD21_MOUSE
NC score	0.032227 (rank : 389)	θ value	1.81305 (rank : 210)
Query Neighborhood Hits	281	Target Neighborhood Hits	1135	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CYTSA_MOUSE
NC score	0.031818 (rank : 390)	θ value	4.03905 (rank : 234)
Query Neighborhood Hits	281	Target Neighborhood Hits	1104	Shared Neighborhood Hits	65
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

BRE1A_MOUSE
NC score	0.030913 (rank : 391)	θ value	2.36792 (rank : 218)
Query Neighborhood Hits	281	Target Neighborhood Hits	1025	Shared Neighborhood Hits	65
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

BCN1_HUMAN
NC score	0.030163 (rank : 392)	θ value	0.62314 (rank : 184)
Query Neighborhood Hits	281	Target Neighborhood Hits	395	Shared Neighborhood Hits	31
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

MRCKB_MOUSE
NC score	0.028738 (rank : 393)	θ value	0.62314 (rank : 187)
Query Neighborhood Hits	281	Target Neighborhood Hits	2180	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TARA_HUMAN
NC score	0.028738 (rank : 394)	θ value	3.0926 (rank : 231)
Query Neighborhood Hits	281	Target Neighborhood Hits	1626	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CF152_HUMAN
NC score	0.027833 (rank : 395)	θ value	8.99809 (rank : 269)
Query Neighborhood Hits	281	Target Neighborhood Hits	704	Shared Neighborhood Hits	47
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

SMC4_MOUSE
NC score	0.025561 (rank : 396)	θ value	8.99809 (rank : 276)
Query Neighborhood Hits	281	Target Neighborhood Hits	830	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

CCD42_HUMAN
NC score	0.025443 (rank : 397)	θ value	8.99809 (rank : 267)
Query Neighborhood Hits	281	Target Neighborhood Hits	406	Shared Neighborhood Hits	39
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

MRCKB_HUMAN
NC score	0.025439 (rank : 398)	θ value	5.27518 (rank : 249)
Query Neighborhood Hits	281	Target Neighborhood Hits	2239	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TP53B_MOUSE
NC score	0.023406 (rank : 399)	θ value	0.62314 (rank : 192)
Query Neighborhood Hits	281	Target Neighborhood Hits	644	Shared Neighborhood Hits	28
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TRI37_MOUSE
NC score	0.022025 (rank : 400)	θ value	1.38821 (rank : 206)
Query Neighborhood Hits	281	Target Neighborhood Hits	316	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRI37_HUMAN
NC score	0.021904 (rank : 401)	θ value	1.38821 (rank : 205)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	16
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

COG7_HUMAN
NC score	0.019976 (rank : 402)	θ value	8.99809 (rank : 270)
Query Neighborhood Hits	281	Target Neighborhood Hits	108	Shared Neighborhood Hits	8
SwissProt Accessions	P83436, Q6UWU7	Gene names	COG7
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 7.

CCDC5_HUMAN
NC score	0.019059 (rank : 403)	θ value	3.0926 (rank : 226)
Query Neighborhood Hits	281	Target Neighborhood Hits	125	Shared Neighborhood Hits	11
SwissProt Accessions	Q96CS2, Q8N837	Gene names	CCDC5, HEIC
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 5 (Enhancer of invasion-cluster) (HEI-C).

MAP4_HUMAN
NC score	0.018550 (rank : 404)	θ value	0.62314 (rank : 186)
Query Neighborhood Hits	281	Target Neighborhood Hits	428	Shared Neighborhood Hits	19
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

ROCK1_MOUSE
NC score	0.017443 (rank : 405)	θ value	1.38821 (rank : 204)
Query Neighborhood Hits	281	Target Neighborhood Hits	2126	Shared Neighborhood Hits	85
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

NCOA6_MOUSE
NC score	0.016757 (rank : 406)	θ value	8.99809 (rank : 273)
Query Neighborhood Hits	281	Target Neighborhood Hits	1076	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ATX1_MOUSE
NC score	0.016724 (rank : 407)	θ value	3.0926 (rank : 225)
Query Neighborhood Hits	281	Target Neighborhood Hits	264	Shared Neighborhood Hits	11
SwissProt Accessions	P54254	Gene names	Atxn1, Sca1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).

LMNB1_MOUSE
NC score	0.015178 (rank : 408)	θ value	5.27518 (rank : 248)
Query Neighborhood Hits	281	Target Neighborhood Hits	719	Shared Neighborhood Hits	46
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

TRI25_MOUSE
NC score	0.015061 (rank : 409)	θ value	0.0736092 (rank : 151)
Query Neighborhood Hits	281	Target Neighborhood Hits	446	Shared Neighborhood Hits	20
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

DCP1A_HUMAN
NC score	0.013945 (rank : 410)	θ value	6.88961 (rank : 257)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

KIF11_HUMAN
NC score	0.013777 (rank : 411)	θ value	5.27518 (rank : 247)
Query Neighborhood Hits	281	Target Neighborhood Hits	583	Shared Neighborhood Hits	45
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

TIP60_HUMAN
NC score	0.013303 (rank : 412)	θ value	2.36792 (rank : 222)
Query Neighborhood Hits	281	Target Neighborhood Hits	90	Shared Neighborhood Hits	6
SwissProt Accessions	Q92993, O95624, Q13430, Q6GSE8, Q9BWK7	Gene names	HTATIP, TIP60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60) (HIV-1 Tat interactive protein) (cPLA(2)-interacting protein).

TIP60_MOUSE
NC score	0.013263 (rank : 413)	θ value	2.36792 (rank : 223)
Query Neighborhood Hits	281	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHK4, Q8CGZ3, Q8CGZ4, Q8VIH0	Gene names	Htatip, Tip60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60).

DCP1A_MOUSE
NC score	0.013221 (rank : 414)	θ value	8.99809 (rank : 271)
Query Neighborhood Hits	281	Target Neighborhood Hits	103	Shared Neighborhood Hits	8
SwissProt Accessions	Q91YD3, Q6NZE3	Gene names	Dcp1a, Mitc1, Smif
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (MAD homolog 4-interacting transcription coactivator 1) (Smad4-interacting transcriptional co-activator).

TBCD4_MOUSE
NC score	0.013213 (rank : 415)	θ value	1.06291 (rank : 201)
Query Neighborhood Hits	281	Target Neighborhood Hits	276	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BYJ6, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2	Gene names	Tbc1d4, Kiaa0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

NIPBL_HUMAN
NC score	0.012482 (rank : 416)	θ value	1.38821 (rank : 203)
Query Neighborhood Hits	281	Target Neighborhood Hits	1311	Shared Neighborhood Hits	45
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NCOA5_MOUSE
NC score	0.012350 (rank : 417)	θ value	4.03905 (rank : 237)
Query Neighborhood Hits	281	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	Q91W39	Gene names	Ncoa5
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

NRG3_HUMAN
NC score	0.012022 (rank : 418)	θ value	5.27518 (rank : 251)
Query Neighborhood Hits	281	Target Neighborhood Hits	119	Shared Neighborhood Hits	7
SwissProt Accessions	P56975	Gene names	NRG3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

HSF1_HUMAN
NC score	0.011470 (rank : 419)	θ value	4.03905 (rank : 236)
Query Neighborhood Hits	281	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

MCEE_HUMAN
NC score	0.011376 (rank : 420)	θ value	6.88961 (rank : 259)
Query Neighborhood Hits	281	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PE7, Q8WW63	Gene names	MCEE
Domain Architecture	No domain graphic available
Description	Methylmalonyl-CoA epimerase, mitochondrial precursor (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase).

MO4L2_HUMAN
NC score	0.010289 (rank : 421)	θ value	6.88961 (rank : 260)
Query Neighborhood Hits	281	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q15014, Q567V0, Q8J026	Gene names	MORF4L2, KIAA0026, MRGX
Domain Architecture
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (MSL3-2 protein).

ARMC4_HUMAN
NC score	0.009867 (rank : 422)	θ value	5.27518 (rank : 242)
Query Neighborhood Hits	281	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

IRF2_MOUSE
NC score	0.009335 (rank : 423)	θ value	2.36792 (rank : 220)
Query Neighborhood Hits	281	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	P23906	Gene names	Irf2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

ADO_HUMAN
NC score	0.009035 (rank : 424)	θ value	3.0926 (rank : 224)
Query Neighborhood Hits	281	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q06278, O14765, Q9UPG6	Gene names	AOX1, AO
Domain Architecture
Description	Aldehyde oxidase (EC 1.2.3.1).

MUCDL_MOUSE
NC score	0.008703 (rank : 425)	θ value	5.27518 (rank : 250)
Query Neighborhood Hits	281	Target Neighborhood Hits	461	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

MYCD_HUMAN
NC score	0.008662 (rank : 426)	θ value	3.0926 (rank : 229)
Query Neighborhood Hits	281	Target Neighborhood Hits	167	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZQ8, Q8N7Q1	Gene names	MYOCD, MYCD
Domain Architecture
Description	Myocardin.

SLK_HUMAN
NC score	0.008371 (rank : 427)	θ value	6.88961 (rank : 263)
Query Neighborhood Hits	281	Target Neighborhood Hits	1775	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

MO4L2_MOUSE
NC score	0.008255 (rank : 428)	θ value	6.88961 (rank : 261)
Query Neighborhood Hits	281	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R0Q4, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2	Gene names	Morf4l2, Kiaa0026, Sid393
Domain Architecture	No domain graphic available
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (Sid 393).

SLK_MOUSE
NC score	0.008236 (rank : 429)	θ value	5.27518 (rank : 252)
Query Neighborhood Hits	281	Target Neighborhood Hits	1798	Shared Neighborhood Hits	76
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SVIL_MOUSE
NC score	0.006356 (rank : 430)	θ value	8.99809 (rank : 277)
Query Neighborhood Hits	281	Target Neighborhood Hits	439	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TTLL5_HUMAN
NC score	0.006200 (rank : 431)	θ value	8.99809 (rank : 279)
Query Neighborhood Hits	281	Target Neighborhood Hits	141	Shared Neighborhood Hits	6
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

CSPG2_MOUSE
NC score	0.005841 (rank : 432)	θ value	1.06291 (rank : 195)
Query Neighborhood Hits	281	Target Neighborhood Hits	711	Shared Neighborhood Hits	15
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

CCNB2_MOUSE
NC score	0.005560 (rank : 433)	θ value	4.03905 (rank : 232)
Query Neighborhood Hits	281	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P30276	Gene names	Ccnb2, Cycb2
Domain Architecture
Description	G2/mitotic-specific cyclin-B2.

FOG2_MOUSE
NC score	0.003148 (rank : 434)	θ value	1.06291 (rank : 196)
Query Neighborhood Hits	281	Target Neighborhood Hits	714	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CCH7, Q9Z0F2	Gene names	Zfpm2, Fog2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (Friend of GATA-2) (FOG-2) (mFOG-2).

LIMD1_MOUSE
NC score	0.003007 (rank : 435)	θ value	6.88961 (rank : 258)
Query Neighborhood Hits	281	Target Neighborhood Hits	291	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

FOG2_HUMAN
NC score	0.002645 (rank : 436)	θ value	1.81305 (rank : 213)
Query Neighborhood Hits	281	Target Neighborhood Hits	731	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WW38, Q9NPL7, Q9NPS4, Q9UNI5	Gene names	ZFPM2, FOG2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (FOG-2) (hFOG-2).

RXRA_HUMAN
NC score	0.002499 (rank : 437)	θ value	0.62314 (rank : 189)
Query Neighborhood Hits	281	Target Neighborhood Hits	223	Shared Neighborhood Hits	4
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

GP112_HUMAN
NC score	0.001828 (rank : 438)	θ value	5.27518 (rank : 245)
Query Neighborhood Hits	281	Target Neighborhood Hits	441	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

MASTL_MOUSE
NC score	0.001426 (rank : 439)	θ value	1.81305 (rank : 215)
Query Neighborhood Hits	281	Target Neighborhood Hits	862	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

TSH1_MOUSE
NC score	0.000127 (rank : 440)	θ value	6.88961 (rank : 266)
Query Neighborhood Hits	281	Target Neighborhood Hits	675	Shared Neighborhood Hits	5
SwissProt Accessions	Q5DTH5, Q6PE60, Q8VD19, Q9JLD5	Gene names	Tshz1, Kiaa4206, Sdccag33, Tsh1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog).

SLIK1_MOUSE
NC score	-0.003067 (rank : 441)	θ value	8.99809 (rank : 275)
Query Neighborhood Hits	281	Target Neighborhood Hits	333	Shared Neighborhood Hits	3
SwissProt Accessions	Q810C1, Q9CXL0	Gene names	Slitrk1, Sltk1
Domain Architecture
Description	SLIT and NTRK-like protein 1 precursor.

GZF1_HUMAN
NC score	-0.010229 (rank : 442)	θ value	8.99809 (rank : 272)
Query Neighborhood Hits	281	Target Neighborhood Hits	854	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H116, Q96N08, Q9BQK9, Q9H117, Q9H6W6	Gene names	GZF1, ZBTB23, ZNF336
Domain Architecture
Description	GDNF-inducible zinc finger protein 1 (Zinc finger protein 336) (Zinc finger and BTB domain-containing protein 23).