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Network neighborhood for query Sequence : CENA2_HUMAN

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CENA2_HUMAN
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CENA2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	83	Target Neighborhood Hits	83	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA2_MOUSE
θ value	0 (rank : 2)	NC score	0.991565 (rank : 2)
Query Neighborhood Hits	83	Target Neighborhood Hits	68	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CENA1_HUMAN
θ value	8.37844e-131 (rank : 3)	NC score	0.973729 (rank : 3)
Query Neighborhood Hits	83	Target Neighborhood Hits	87	Shared Neighborhood Hits	62
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SMP1L_MOUSE
θ value	7.82807e-20 (rank : 4)	NC score	0.800358 (rank : 4)
Query Neighborhood Hits	83	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMP1L_HUMAN
θ value	2.97466e-19 (rank : 5)	NC score	0.800246 (rank : 5)
Query Neighborhood Hits	83	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMAP1_MOUSE
θ value	7.32683e-18 (rank : 6)	NC score	0.796294 (rank : 7)
Query Neighborhood Hits	83	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_HUMAN
θ value	9.56915e-18 (rank : 7)	NC score	0.797703 (rank : 6)
Query Neighborhood Hits	83	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CENG3_HUMAN
θ value	2.7842e-17 (rank : 8)	NC score	0.619130 (rank : 14)
Query Neighborhood Hits	83	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	6.20254e-17 (rank : 9)	NC score	0.618326 (rank : 15)
Query Neighborhood Hits	83	Target Neighborhood Hits	467	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENB1_HUMAN
θ value	1.058e-16 (rank : 10)	NC score	0.615233 (rank : 16)
Query Neighborhood Hits	83	Target Neighborhood Hits	383	Shared Neighborhood Hits	65
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	3.07829e-16 (rank : 11)	NC score	0.594808 (rank : 19)
Query Neighborhood Hits	83	Target Neighborhood Hits	425	Shared Neighborhood Hits	66
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	6.85773e-16 (rank : 12)	NC score	0.603510 (rank : 18)
Query Neighborhood Hits	83	Target Neighborhood Hits	395	Shared Neighborhood Hits	65
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENG2_HUMAN
θ value	1.16975e-15 (rank : 13)	NC score	0.591104 (rank : 22)
Query Neighborhood Hits	83	Target Neighborhood Hits	471	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	1.52774e-15 (rank : 14)	NC score	0.594026 (rank : 20)
Query Neighborhood Hits	83	Target Neighborhood Hits	463	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG1_HUMAN
θ value	1.29331e-14 (rank : 15)	NC score	0.613643 (rank : 17)
Query Neighborhood Hits	83	Target Neighborhood Hits	544	Shared Neighborhood Hits	41
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	1.68911e-14 (rank : 16)	NC score	0.620218 (rank : 13)
Query Neighborhood Hits	83	Target Neighborhood Hits	531	Shared Neighborhood Hits	41
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

DDFL1_HUMAN
θ value	7.84624e-12 (rank : 17)	NC score	0.624843 (rank : 12)
Query Neighborhood Hits	83	Target Neighborhood Hits	353	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
θ value	1.74796e-11 (rank : 18)	NC score	0.593373 (rank : 21)
Query Neighborhood Hits	83	Target Neighborhood Hits	324	Shared Neighborhood Hits	44
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CEND3_MOUSE
θ value	1.47974e-10 (rank : 19)	NC score	0.529268 (rank : 32)
Query Neighborhood Hits	83	Target Neighborhood Hits	228	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

DDEF1_MOUSE
θ value	1.47974e-10 (rank : 20)	NC score	0.586741 (rank : 23)
Query Neighborhood Hits	83	Target Neighborhood Hits	592	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_MOUSE
θ value	2.52405e-10 (rank : 21)	NC score	0.562922 (rank : 26)
Query Neighborhood Hits	83	Target Neighborhood Hits	625	Shared Neighborhood Hits	47
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CEND3_HUMAN
θ value	4.30538e-10 (rank : 22)	NC score	0.531497 (rank : 31)
Query Neighborhood Hits	83	Target Neighborhood Hits	275	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

DDEF2_HUMAN
θ value	5.62301e-10 (rank : 23)	NC score	0.565025 (rank : 25)
Query Neighborhood Hits	83	Target Neighborhood Hits	599	Shared Neighborhood Hits	47
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CEND1_HUMAN
θ value	9.59137e-10 (rank : 24)	NC score	0.554474 (rank : 28)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND2_HUMAN
θ value	9.59137e-10 (rank : 25)	NC score	0.543423 (rank : 30)
Query Neighborhood Hits	83	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

ARFG1_MOUSE
θ value	1.63604e-09 (rank : 26)	NC score	0.708871 (rank : 8)
Query Neighborhood Hits	83	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CEND1_MOUSE
θ value	2.79066e-09 (rank : 27)	NC score	0.546020 (rank : 29)
Query Neighborhood Hits	83	Target Neighborhood Hits	260	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

ARFG1_HUMAN
θ value	3.64472e-09 (rank : 28)	NC score	0.694824 (rank : 9)
Query Neighborhood Hits	83	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

GIT1_HUMAN
θ value	2.61198e-07 (rank : 29)	NC score	0.509470 (rank : 36)
Query Neighborhood Hits	83	Target Neighborhood Hits	336	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	2.61198e-07 (rank : 30)	NC score	0.506911 (rank : 37)
Query Neighborhood Hits	83	Target Neighborhood Hits	341	Shared Neighborhood Hits	36
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

HRBL_MOUSE
θ value	3.41135e-07 (rank : 31)	NC score	0.498903 (rank : 38)
Query Neighborhood Hits	83	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

GIT2_MOUSE
θ value	5.81887e-07 (rank : 32)	NC score	0.515782 (rank : 34)
Query Neighborhood Hits	83	Target Neighborhood Hits	323	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

HRBL_HUMAN
θ value	1.29631e-06 (rank : 33)	NC score	0.521369 (rank : 33)
Query Neighborhood Hits	83	Target Neighborhood Hits	179	Shared Neighborhood Hits	36
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

GIT2_HUMAN
θ value	1.69304e-06 (rank : 34)	NC score	0.515096 (rank : 35)
Query Neighborhood Hits	83	Target Neighborhood Hits	381	Shared Neighborhood Hits	39
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

ARFG3_MOUSE
θ value	2.21117e-06 (rank : 35)	NC score	0.665187 (rank : 11)
Query Neighborhood Hits	83	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_HUMAN
θ value	2.88788e-06 (rank : 36)	NC score	0.669870 (rank : 10)
Query Neighborhood Hits	83	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

NUPL_HUMAN
θ value	8.40245e-06 (rank : 37)	NC score	0.566672 (rank : 24)
Query Neighborhood Hits	83	Target Neighborhood Hits	68	Shared Neighborhood Hits	36
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	8.40245e-06 (rank : 38)	NC score	0.561111 (rank : 27)
Query Neighborhood Hits	83	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

PHLB2_MOUSE
θ value	0.00134147 (rank : 39)	NC score	0.096463 (rank : 72)
Query Neighborhood Hits	83	Target Neighborhood Hits	1016	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
θ value	0.00175202 (rank : 40)	NC score	0.094358 (rank : 73)
Query Neighborhood Hits	83	Target Neighborhood Hits	964	Shared Neighborhood Hits	33
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB1_MOUSE
θ value	0.00298849 (rank : 41)	NC score	0.115520 (rank : 58)
Query Neighborhood Hits	83	Target Neighborhood Hits	678	Shared Neighborhood Hits	32
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PLEK2_HUMAN
θ value	0.0193708 (rank : 42)	NC score	0.161427 (rank : 43)
Query Neighborhood Hits	83	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

CYH3_HUMAN
θ value	0.0330416 (rank : 43)	NC score	0.125988 (rank : 49)
Query Neighborhood Hits	83	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DGKH_HUMAN
θ value	0.0431538 (rank : 44)	NC score	0.107437 (rank : 62)
Query Neighborhood Hits	83	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PLEK2_MOUSE
θ value	0.0563607 (rank : 45)	NC score	0.137174 (rank : 44)
Query Neighborhood Hits	83	Target Neighborhood Hits	96	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

DAPP1_HUMAN
θ value	0.0736092 (rank : 46)	NC score	0.133645 (rank : 45)
Query Neighborhood Hits	83	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

OSB10_HUMAN
θ value	0.0736092 (rank : 47)	NC score	0.042279 (rank : 205)
Query Neighborhood Hits	83	Target Neighborhood Hits	55	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

RHG25_HUMAN
θ value	0.0736092 (rank : 48)	NC score	0.100157 (rank : 68)
Query Neighborhood Hits	83	Target Neighborhood Hits	550	Shared Neighborhood Hits	44
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH2_HUMAN
θ value	0.0961366 (rank : 49)	NC score	0.124269 (rank : 52)
Query Neighborhood Hits	83	Target Neighborhood Hits	175	Shared Neighborhood Hits	48
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.0961366 (rank : 50)	NC score	0.124161 (rank : 53)
Query Neighborhood Hits	83	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

MTMR5_HUMAN
θ value	0.0961366 (rank : 51)	NC score	0.082604 (rank : 79)
Query Neighborhood Hits	83	Target Neighborhood Hits	141	Shared Neighborhood Hits	32
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PHLB1_HUMAN
θ value	0.0961366 (rank : 52)	NC score	0.092962 (rank : 75)
Query Neighborhood Hits	83	Target Neighborhood Hits	1038	Shared Neighborhood Hits	32
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RHG25_MOUSE
θ value	0.0961366 (rank : 53)	NC score	0.107676 (rank : 61)
Query Neighborhood Hits	83	Target Neighborhood Hits	492	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH3_MOUSE
θ value	0.125558 (rank : 54)	NC score	0.117257 (rank : 57)
Query Neighborhood Hits	83	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

RASA3_HUMAN
θ value	0.21417 (rank : 55)	NC score	0.069629 (rank : 93)
Query Neighborhood Hits	83	Target Neighborhood Hits	166	Shared Neighborhood Hits	33
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

MTMRD_HUMAN
θ value	0.279714 (rank : 56)	NC score	0.082259 (rank : 81)
Query Neighborhood Hits	83	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

PKHA4_MOUSE
θ value	0.279714 (rank : 57)	NC score	0.132155 (rank : 46)
Query Neighborhood Hits	83	Target Neighborhood Hits	202	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RASA3_MOUSE
θ value	0.279714 (rank : 58)	NC score	0.067158 (rank : 98)
Query Neighborhood Hits	83	Target Neighborhood Hits	144	Shared Neighborhood Hits	31
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

DGKD_HUMAN
θ value	0.365318 (rank : 59)	NC score	0.091493 (rank : 77)
Query Neighborhood Hits	83	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

PKHA1_MOUSE
θ value	0.365318 (rank : 60)	NC score	0.212942 (rank : 40)
Query Neighborhood Hits	83	Target Neighborhood Hits	120	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA4_HUMAN
θ value	0.365318 (rank : 61)	NC score	0.124915 (rank : 51)
Query Neighborhood Hits	83	Target Neighborhood Hits	283	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA1_HUMAN
θ value	0.47712 (rank : 62)	NC score	0.216461 (rank : 39)
Query Neighborhood Hits	83	Target Neighborhood Hits	127	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

SWP70_MOUSE
θ value	0.62314 (rank : 63)	NC score	0.070757 (rank : 90)
Query Neighborhood Hits	83	Target Neighborhood Hits	1097	Shared Neighborhood Hits	45
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH1_HUMAN
θ value	0.813845 (rank : 64)	NC score	0.122532 (rank : 54)
Query Neighborhood Hits	83	Target Neighborhood Hits	184	Shared Neighborhood Hits	47
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PKHA2_HUMAN
θ value	1.06291 (rank : 65)	NC score	0.163068 (rank : 42)
Query Neighborhood Hits	83	Target Neighborhood Hits	119	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	1.06291 (rank : 66)	NC score	0.169883 (rank : 41)
Query Neighborhood Hits	83	Target Neighborhood Hits	116	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

SWP70_HUMAN
θ value	1.06291 (rank : 67)	NC score	0.068796 (rank : 96)
Query Neighborhood Hits	83	Target Neighborhood Hits	973	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH1_MOUSE
θ value	1.81305 (rank : 68)	NC score	0.121122 (rank : 55)
Query Neighborhood Hits	83	Target Neighborhood Hits	176	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

GNRP_HUMAN
θ value	1.81305 (rank : 69)	NC score	0.046328 (rank : 203)
Query Neighborhood Hits	83	Target Neighborhood Hits	239	Shared Neighborhood Hits	29
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

MLE1_MOUSE
θ value	1.81305 (rank : 70)	NC score	0.016853 (rank : 210)
Query Neighborhood Hits	83	Target Neighborhood Hits	69	Shared Neighborhood Hits	5
SwissProt Accessions	P05977	Gene names	Myl1, Mylf
Domain Architecture
Description	Myosin light chain 1, skeletal muscle isoform (MLC1F) (A1 catalytic) (Alkali myosin light chain 1).

MLE3_MOUSE
θ value	1.81305 (rank : 71)	NC score	0.017000 (rank : 209)
Query Neighborhood Hits	83	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	P05978	Gene names	Myl1, Mylf
Domain Architecture
Description	Myosin light chain 3, skeletal muscle isoform (A2 catalytic) (Alkali myosin light chain 3) (MLC3F).

GNRP_MOUSE
θ value	2.36792 (rank : 72)	NC score	0.043776 (rank : 204)
Query Neighborhood Hits	83	Target Neighborhood Hits	191	Shared Neighborhood Hits	29
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

3BP2_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.076890 (rank : 84)
Query Neighborhood Hits	83	Target Neighborhood Hits	296	Shared Neighborhood Hits	34
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

DGKK_HUMAN
θ value	3.0926 (rank : 74)	NC score	0.057720 (rank : 121)
Query Neighborhood Hits	83	Target Neighborhood Hits	378	Shared Neighborhood Hits	23
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

CYH4_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.107012 (rank : 63)
Query Neighborhood Hits	83	Target Neighborhood Hits	135	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PLEK_MOUSE
θ value	5.27518 (rank : 76)	NC score	0.106798 (rank : 64)
Query Neighborhood Hits	83	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RASA2_HUMAN
θ value	5.27518 (rank : 77)	NC score	0.056038 (rank : 138)
Query Neighborhood Hits	83	Target Neighborhood Hits	157	Shared Neighborhood Hits	24
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

ALS2_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.017947 (rank : 207)
Query Neighborhood Hits	83	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.017934 (rank : 208)
Query Neighborhood Hits	83	Target Neighborhood Hits	111	Shared Neighborhood Hits	8
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

3BP2_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.069915 (rank : 91)
Query Neighborhood Hits	83	Target Neighborhood Hits	142	Shared Neighborhood Hits	32
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

FGD6_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.022268 (rank : 206)
Query Neighborhood Hits	83	Target Neighborhood Hits	237	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

MLE1_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.013105 (rank : 212)
Query Neighborhood Hits	83	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	P05976	Gene names	MYL1
Domain Architecture
Description	Myosin light chain 1, skeletal muscle isoform (MLC1F) (A1 catalytic) (Alkali myosin light chain 1).

MLE3_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.013136 (rank : 211)
Query Neighborhood Hits	83	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	P06741	Gene names	MYL1
Domain Architecture
Description	Myosin light chain 3, skeletal muscle isoform (A2 catalytic) (Alkali myosin light chain 3) (MLC3F).

ABR_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.053032 (rank : 163)
Query Neighborhood Hits	83	Target Neighborhood Hits	166	Shared Neighborhood Hits	10
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACBD6_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.053909 (rank : 158)
Query Neighborhood Hits	83	Target Neighborhood Hits	304	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ACBD6_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.052429 (rank : 169)
Query Neighborhood Hits	83	Target Neighborhood Hits	305	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

AN13B_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.051117 (rank : 192)
Query Neighborhood Hits	83	Target Neighborhood Hits	265	Shared Neighborhood Hits	15
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.051191 (rank : 190)
Query Neighborhood Hits	83	Target Neighborhood Hits	276	Shared Neighborhood Hits	15
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

ANK1_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.056568 (rank : 128)
Query Neighborhood Hits	83	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK1_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.056319 (rank : 133)
Query Neighborhood Hits	83	Target Neighborhood Hits	430	Shared Neighborhood Hits	18
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANKR1_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.054693 (rank : 150)
Query Neighborhood Hits	83	Target Neighborhood Hits	308	Shared Neighborhood Hits	18
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ANKR1_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.056057 (rank : 137)
Query Neighborhood Hits	83	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

ANKR2_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.060313 (rank : 109)
Query Neighborhood Hits	83	Target Neighborhood Hits	321	Shared Neighborhood Hits	18
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKR2_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.055150 (rank : 145)
Query Neighborhood Hits	83	Target Neighborhood Hits	312	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

ANKR5_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.051799 (rank : 176)
Query Neighborhood Hits	83	Target Neighborhood Hits	297	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANKR5_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.051855 (rank : 174)
Query Neighborhood Hits	83	Target Neighborhood Hits	298	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANKR6_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.059141 (rank : 115)
Query Neighborhood Hits	83	Target Neighborhood Hits	439	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANR10_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.059544 (rank : 111)
Query Neighborhood Hits	83	Target Neighborhood Hits	289	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR10_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.056547 (rank : 129)
Query Neighborhood Hits	83	Target Neighborhood Hits	273	Shared Neighborhood Hits	18
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR15_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.051392 (rank : 185)
Query Neighborhood Hits	83	Target Neighborhood Hits	478	Shared Neighborhood Hits	20
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ANR22_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.054554 (rank : 151)
Query Neighborhood Hits	83	Target Neighborhood Hits	243	Shared Neighborhood Hits	10
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ANR23_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.055029 (rank : 146)
Query Neighborhood Hits	83	Target Neighborhood Hits	291	Shared Neighborhood Hits	18
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ANR23_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.052256 (rank : 171)
Query Neighborhood Hits	83	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

ANR28_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.051179 (rank : 191)
Query Neighborhood Hits	83	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.051697 (rank : 179)
Query Neighborhood Hits	83	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR33_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.061214 (rank : 107)
Query Neighborhood Hits	83	Target Neighborhood Hits	215	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR33_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.050663 (rank : 198)
Query Neighborhood Hits	83	Target Neighborhood Hits	225	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR35_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.055465 (rank : 144)
Query Neighborhood Hits	83	Target Neighborhood Hits	784	Shared Neighborhood Hits	21
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

ANR37_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.069398 (rank : 95)
Query Neighborhood Hits	83	Target Neighborhood Hits	247	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR37_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.079792 (rank : 83)
Query Neighborhood Hits	83	Target Neighborhood Hits	237	Shared Neighborhood Hits	16
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR39_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.072772 (rank : 86)
Query Neighborhood Hits	83	Target Neighborhood Hits	285	Shared Neighborhood Hits	18
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.073011 (rank : 85)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR41_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.082495 (rank : 80)
Query Neighborhood Hits	83	Target Neighborhood Hits	332	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR42_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.057361 (rank : 124)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR42_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.053160 (rank : 160)
Query Neighborhood Hits	83	Target Neighborhood Hits	334	Shared Neighborhood Hits	18
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR44_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.053046 (rank : 162)
Query Neighborhood Hits	83	Target Neighborhood Hits	318	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANR46_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.082969 (rank : 78)
Query Neighborhood Hits	83	Target Neighborhood Hits	281	Shared Neighborhood Hits	17
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR46_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.081056 (rank : 82)
Query Neighborhood Hits	83	Target Neighborhood Hits	274	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR49_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.051752 (rank : 177)
Query Neighborhood Hits	83	Target Neighborhood Hits	282	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

ANR50_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.053027 (rank : 164)
Query Neighborhood Hits	83	Target Neighborhood Hits	361	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

ANR52_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.056421 (rank : 131)
Query Neighborhood Hits	83	Target Neighborhood Hits	322	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.056515 (rank : 130)
Query Neighborhood Hits	83	Target Neighborhood Hits	318	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANRA2_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.057515 (rank : 123)
Query Neighborhood Hits	83	Target Neighborhood Hits	288	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ANRA2_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.058342 (rank : 118)
Query Neighborhood Hits	83	Target Neighborhood Hits	287	Shared Neighborhood Hits	17
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ANS4B_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.065233 (rank : 100)
Query Neighborhood Hits	83	Target Neighborhood Hits	289	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANS4B_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.071620 (rank : 88)
Query Neighborhood Hits	83	Target Neighborhood Hits	294	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB10_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.058810 (rank : 116)
Query Neighborhood Hits	83	Target Neighborhood Hits	291	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ASB10_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.056135 (rank : 136)
Query Neighborhood Hits	83	Target Neighborhood Hits	301	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ASB12_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.050845 (rank : 195)
Query Neighborhood Hits	83	Target Neighborhood Hits	263	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB12_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.050902 (rank : 194)
Query Neighborhood Hits	83	Target Neighborhood Hits	261	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB16_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.050298 (rank : 201)
Query Neighborhood Hits	83	Target Neighborhood Hits	286	Shared Neighborhood Hits	18
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ASB3_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.051277 (rank : 186)
Query Neighborhood Hits	83	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ASB7_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.050296 (rank : 202)
Query Neighborhood Hits	83	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.050314 (rank : 200)
Query Neighborhood Hits	83	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB8_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.056202 (rank : 135)
Query Neighborhood Hits	83	Target Neighborhood Hits	294	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ASB8_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.055744 (rank : 140)
Query Neighborhood Hits	83	Target Neighborhood Hits	293	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

BARD1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.053115 (rank : 161)
Query Neighborhood Hits	83	Target Neighborhood Hits	427	Shared Neighborhood Hits	18
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

BARD1_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.050768 (rank : 196)
Query Neighborhood Hits	83	Target Neighborhood Hits	411	Shared Neighborhood Hits	18
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

BCL3_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.054152 (rank : 155)
Query Neighborhood Hits	83	Target Neighborhood Hits	324	Shared Neighborhood Hits	19
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

BCL3_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.054410 (rank : 152)
Query Neighborhood Hits	83	Target Neighborhood Hits	388	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

BCR_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.053969 (rank : 157)
Query Neighborhood Hits	83	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CDN2D_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.063544 (rank : 104)
Query Neighborhood Hits	83	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CDN2D_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.053872 (rank : 159)
Query Neighborhood Hits	83	Target Neighborhood Hits	267	Shared Neighborhood Hits	13
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CNKR1_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.065032 (rank : 101)
Query Neighborhood Hits	83	Target Neighborhood Hits	154	Shared Neighborhood Hits	28
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CSKI1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.051094 (rank : 193)
Query Neighborhood Hits	83	Target Neighborhood Hits	997	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.051239 (rank : 188)
Query Neighborhood Hits	83	Target Neighborhood Hits	1031	Shared Neighborhood Hits	26
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI2_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.052962 (rank : 166)
Query Neighborhood Hits	83	Target Neighborhood Hits	747	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.052042 (rank : 173)
Query Neighborhood Hits	83	Target Neighborhood Hits	812	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CT086_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.101457 (rank : 67)
Query Neighborhood Hits	83	Target Neighborhood Hits	277	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

CYH4_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.105294 (rank : 65)
Query Neighborhood Hits	83	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DAPP1_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.125508 (rank : 50)
Query Neighborhood Hits	83	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DGKI_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.050485 (rank : 199)
Query Neighborhood Hits	83	Target Neighborhood Hits	609	Shared Neighborhood Hits	17
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

DP13A_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.099461 (rank : 69)
Query Neighborhood Hits	83	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.099121 (rank : 70)
Query Neighborhood Hits	83	Target Neighborhood Hits	96	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.093016 (rank : 74)
Query Neighborhood Hits	83	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.098203 (rank : 71)
Query Neighborhood Hits	83	Target Neighborhood Hits	58	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

EHMT2_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.051707 (rank : 178)
Query Neighborhood Hits	83	Target Neighborhood Hits	498	Shared Neighborhood Hits	19
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

GAB1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.051273 (rank : 187)
Query Neighborhood Hits	83	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB2_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.058028 (rank : 120)
Query Neighborhood Hits	83	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.052155 (rank : 172)
Query Neighborhood Hits	83	Target Neighborhood Hits	220	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GABP2_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.069752 (rank : 92)
Query Neighborhood Hits	83	Target Neighborhood Hits	454	Shared Neighborhood Hits	20
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.069436 (rank : 94)
Query Neighborhood Hits	83	Target Neighborhood Hits	429	Shared Neighborhood Hits	20
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

GABP3_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.071005 (rank : 89)
Query Neighborhood Hits	83	Target Neighborhood Hits	330	Shared Neighborhood Hits	18
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

GMIP_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.053026 (rank : 165)
Query Neighborhood Hits	83	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GMIP_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.056880 (rank : 126)
Query Neighborhood Hits	83	Target Neighborhood Hits	202	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GRLF1_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.051554 (rank : 181)
Query Neighborhood Hits	83	Target Neighborhood Hits	167	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

HECD1_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.062797 (rank : 105)
Query Neighborhood Hits	83	Target Neighborhood Hits	371	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

IKBB_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.063641 (rank : 103)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

IKBB_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.072716 (rank : 87)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

MTPN_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.065649 (rank : 99)
Query Neighborhood Hits	83	Target Neighborhood Hits	269	Shared Neighborhood Hits	16
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.067482 (rank : 97)
Query Neighborhood Hits	83	Target Neighborhood Hits	269	Shared Neighborhood Hits	16
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

MYPT1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.060583 (rank : 108)
Query Neighborhood Hits	83	Target Neighborhood Hits	723	Shared Neighborhood Hits	22
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

MYPT1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.059540 (rank : 112)
Query Neighborhood Hits	83	Target Neighborhood Hits	539	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

MYPT2_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.052277 (rank : 170)
Query Neighborhood Hits	83	Target Neighborhood Hits	707	Shared Neighborhood Hits	17
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

OPHN1_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.107706 (rank : 60)
Query Neighborhood Hits	83	Target Neighborhood Hits	161	Shared Neighborhood Hits	13
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.117982 (rank : 56)
Query Neighborhood Hits	83	Target Neighborhood Hits	174	Shared Neighborhood Hits	15
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OSBL9_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.059594 (rank : 110)
Query Neighborhood Hits	83	Target Neighborhood Hits	138	Shared Neighborhood Hits	39
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSBP1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.054176 (rank : 154)
Query Neighborhood Hits	83	Target Neighborhood Hits	180	Shared Neighborhood Hits	40
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PA2G6_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.054233 (rank : 153)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

PKHA5_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.091878 (rank : 76)
Query Neighborhood Hits	83	Target Neighborhood Hits	455	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.132142 (rank : 47)
Query Neighborhood Hits	83	Target Neighborhood Hits	556	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.130214 (rank : 48)
Query Neighborhood Hits	83	Target Neighborhood Hits	591	Shared Neighborhood Hits	49
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.109809 (rank : 59)
Query Neighborhood Hits	83	Target Neighborhood Hits	110	Shared Neighborhood Hits	45
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PP16A_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.051840 (rank : 175)
Query Neighborhood Hits	83	Target Neighborhood Hits	318	Shared Neighborhood Hits	17
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

PSD10_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.056792 (rank : 127)
Query Neighborhood Hits	83	Target Neighborhood Hits	301	Shared Neighborhood Hits	18
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

PSD10_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.055557 (rank : 143)
Query Neighborhood Hits	83	Target Neighborhood Hits	293	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

RAI14_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.055565 (rank : 142)
Query Neighborhood Hits	83	Target Neighborhood Hits	1367	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RAI14_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.051218 (rank : 189)
Query Neighborhood Hits	83	Target Neighborhood Hits	1505	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RASA2_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.050758 (rank : 197)
Query Neighborhood Hits	83	Target Neighborhood Hits	159	Shared Neighborhood Hits	25
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RBP1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.059352 (rank : 113)
Query Neighborhood Hits	83	Target Neighborhood Hits	521	Shared Neighborhood Hits	12
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.057717 (rank : 122)
Query Neighborhood Hits	83	Target Neighborhood Hits	493	Shared Neighborhood Hits	11
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RGAP1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.055633 (rank : 141)
Query Neighborhood Hits	83	Target Neighborhood Hits	189	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.057315 (rank : 125)
Query Neighborhood Hits	83	Target Neighborhood Hits	185	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG05_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.054121 (rank : 156)
Query Neighborhood Hits	83	Target Neighborhood Hits	158	Shared Neighborhood Hits	7
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.054830 (rank : 147)
Query Neighborhood Hits	83	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG06_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.056380 (rank : 132)
Query Neighborhood Hits	83	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.056280 (rank : 134)
Query Neighborhood Hits	83	Target Neighborhood Hits	105	Shared Neighborhood Hits	8
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG09_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.063770 (rank : 102)
Query Neighborhood Hits	83	Target Neighborhood Hits	186	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.051478 (rank : 183)
Query Neighborhood Hits	83	Target Neighborhood Hits	190	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.052959 (rank : 167)
Query Neighborhood Hits	83	Target Neighborhood Hits	204	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG18_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.054774 (rank : 148)
Query Neighborhood Hits	83	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG18_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.052452 (rank : 168)
Query Neighborhood Hits	83	Target Neighborhood Hits	110	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG26_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.104192 (rank : 66)
Query Neighborhood Hits	83	Target Neighborhood Hits	281	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SHAN1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.051490 (rank : 182)
Query Neighborhood Hits	83	Target Neighborhood Hits	1041	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

TAGAP_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.054766 (rank : 149)
Query Neighborhood Hits	83	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.051621 (rank : 180)
Query Neighborhood Hits	83	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.055979 (rank : 139)
Query Neighborhood Hits	83	Target Neighborhood Hits	872	Shared Neighborhood Hits	14
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.051406 (rank : 184)
Query Neighborhood Hits	83	Target Neighborhood Hits	409	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TNKS1_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.062256 (rank : 106)
Query Neighborhood Hits	83	Target Neighborhood Hits	477	Shared Neighborhood Hits	25
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

TNKS2_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.059253 (rank : 114)
Query Neighborhood Hits	83	Target Neighborhood Hits	361	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

USH1G_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.058301 (rank : 119)
Query Neighborhood Hits	83	Target Neighborhood Hits	267	Shared Neighborhood Hits	18
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.058580 (rank : 117)
Query Neighborhood Hits	83	Target Neighborhood Hits	271	Shared Neighborhood Hits	18
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

Hits sorted by NC score

CENA2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	83	Target Neighborhood Hits	83	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA2_MOUSE
NC score	0.991565 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	83	Target Neighborhood Hits	68	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CENA1_HUMAN
NC score	0.973729 (rank : 3)	θ value	8.37844e-131 (rank : 3)
Query Neighborhood Hits	83	Target Neighborhood Hits	87	Shared Neighborhood Hits	62
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SMP1L_MOUSE
NC score	0.800358 (rank : 4)	θ value	7.82807e-20 (rank : 4)
Query Neighborhood Hits	83	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMP1L_HUMAN
NC score	0.800246 (rank : 5)	θ value	2.97466e-19 (rank : 5)
Query Neighborhood Hits	83	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMAP1_HUMAN
NC score	0.797703 (rank : 6)	θ value	9.56915e-18 (rank : 7)
Query Neighborhood Hits	83	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
NC score	0.796294 (rank : 7)	θ value	7.32683e-18 (rank : 6)
Query Neighborhood Hits	83	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

ARFG1_MOUSE
NC score	0.708871 (rank : 8)	θ value	1.63604e-09 (rank : 26)
Query Neighborhood Hits	83	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_HUMAN
NC score	0.694824 (rank : 9)	θ value	3.64472e-09 (rank : 28)
Query Neighborhood Hits	83	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_HUMAN
NC score	0.669870 (rank : 10)	θ value	2.88788e-06 (rank : 36)
Query Neighborhood Hits	83	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
NC score	0.665187 (rank : 11)	θ value	2.21117e-06 (rank : 35)
Query Neighborhood Hits	83	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

DDFL1_HUMAN
NC score	0.624843 (rank : 12)	θ value	7.84624e-12 (rank : 17)
Query Neighborhood Hits	83	Target Neighborhood Hits	353	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

CENG1_MOUSE
NC score	0.620218 (rank : 13)	θ value	1.68911e-14 (rank : 16)
Query Neighborhood Hits	83	Target Neighborhood Hits	531	Shared Neighborhood Hits	41
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG3_HUMAN
NC score	0.619130 (rank : 14)	θ value	2.7842e-17 (rank : 8)
Query Neighborhood Hits	83	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
NC score	0.618326 (rank : 15)	θ value	6.20254e-17 (rank : 9)
Query Neighborhood Hits	83	Target Neighborhood Hits	467	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENB1_HUMAN
NC score	0.615233 (rank : 16)	θ value	1.058e-16 (rank : 10)
Query Neighborhood Hits	83	Target Neighborhood Hits	383	Shared Neighborhood Hits	65
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENG1_HUMAN
NC score	0.613643 (rank : 17)	θ value	1.29331e-14 (rank : 15)
Query Neighborhood Hits	83	Target Neighborhood Hits	544	Shared Neighborhood Hits	41
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENB5_HUMAN
NC score	0.603510 (rank : 18)	θ value	6.85773e-16 (rank : 12)
Query Neighborhood Hits	83	Target Neighborhood Hits	395	Shared Neighborhood Hits	65
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENB2_HUMAN
NC score	0.594808 (rank : 19)	θ value	3.07829e-16 (rank : 11)
Query Neighborhood Hits	83	Target Neighborhood Hits	425	Shared Neighborhood Hits	66
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENG2_MOUSE
NC score	0.594026 (rank : 20)	θ value	1.52774e-15 (rank : 14)
Query Neighborhood Hits	83	Target Neighborhood Hits	463	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

DDFL1_MOUSE
NC score	0.593373 (rank : 21)	θ value	1.74796e-11 (rank : 18)
Query Neighborhood Hits	83	Target Neighborhood Hits	324	Shared Neighborhood Hits	44
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CENG2_HUMAN
NC score	0.591104 (rank : 22)	θ value	1.16975e-15 (rank : 13)
Query Neighborhood Hits	83	Target Neighborhood Hits	471	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

DDEF1_MOUSE
NC score	0.586741 (rank : 23)	θ value	1.47974e-10 (rank : 20)
Query Neighborhood Hits	83	Target Neighborhood Hits	592	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

NUPL_HUMAN
NC score	0.566672 (rank : 24)	θ value	8.40245e-06 (rank : 37)
Query Neighborhood Hits	83	Target Neighborhood Hits	68	Shared Neighborhood Hits	36
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

DDEF2_HUMAN
NC score	0.565025 (rank : 25)	θ value	5.62301e-10 (rank : 23)
Query Neighborhood Hits	83	Target Neighborhood Hits	599	Shared Neighborhood Hits	47
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.562922 (rank : 26)	θ value	2.52405e-10 (rank : 21)
Query Neighborhood Hits	83	Target Neighborhood Hits	625	Shared Neighborhood Hits	47
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

NUPL_MOUSE
NC score	0.561111 (rank : 27)	θ value	8.40245e-06 (rank : 38)
Query Neighborhood Hits	83	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

CEND1_HUMAN
NC score	0.554474 (rank : 28)	θ value	9.59137e-10 (rank : 24)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
NC score	0.546020 (rank : 29)	θ value	2.79066e-09 (rank : 27)
Query Neighborhood Hits	83	Target Neighborhood Hits	260	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
NC score	0.543423 (rank : 30)	θ value	9.59137e-10 (rank : 25)
Query Neighborhood Hits	83	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
NC score	0.531497 (rank : 31)	θ value	4.30538e-10 (rank : 22)
Query Neighborhood Hits	83	Target Neighborhood Hits	275	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
NC score	0.529268 (rank : 32)	θ value	1.47974e-10 (rank : 19)
Query Neighborhood Hits	83	Target Neighborhood Hits	228	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

HRBL_HUMAN
NC score	0.521369 (rank : 33)	θ value	1.29631e-06 (rank : 33)
Query Neighborhood Hits	83	Target Neighborhood Hits	179	Shared Neighborhood Hits	36
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

GIT2_MOUSE
NC score	0.515782 (rank : 34)	θ value	5.81887e-07 (rank : 32)
Query Neighborhood Hits	83	Target Neighborhood Hits	323	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_HUMAN
NC score	0.515096 (rank : 35)	θ value	1.69304e-06 (rank : 34)
Query Neighborhood Hits	83	Target Neighborhood Hits	381	Shared Neighborhood Hits	39
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT1_HUMAN
NC score	0.509470 (rank : 36)	θ value	2.61198e-07 (rank : 29)
Query Neighborhood Hits	83	Target Neighborhood Hits	336	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
NC score	0.506911 (rank : 37)	θ value	2.61198e-07 (rank : 30)
Query Neighborhood Hits	83	Target Neighborhood Hits	341	Shared Neighborhood Hits	36
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

HRBL_MOUSE
NC score	0.498903 (rank : 38)	θ value	3.41135e-07 (rank : 31)
Query Neighborhood Hits	83	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

PKHA1_HUMAN
NC score	0.216461 (rank : 39)	θ value	0.47712 (rank : 62)
Query Neighborhood Hits	83	Target Neighborhood Hits	127	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.212942 (rank : 40)	θ value	0.365318 (rank : 60)
Query Neighborhood Hits	83	Target Neighborhood Hits	120	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
NC score	0.169883 (rank : 41)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	83	Target Neighborhood Hits	116	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA2_HUMAN
NC score	0.163068 (rank : 42)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	83	Target Neighborhood Hits	119	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLEK2_HUMAN
NC score	0.161427 (rank : 43)	θ value	0.0193708 (rank : 42)
Query Neighborhood Hits	83	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
NC score	0.137174 (rank : 44)	θ value	0.0563607 (rank : 45)
Query Neighborhood Hits	83	Target Neighborhood Hits	96	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

DAPP1_HUMAN
NC score	0.133645 (rank : 45)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	83	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA4_MOUSE
NC score	0.132155 (rank : 46)	θ value	0.279714 (rank : 57)
Query Neighborhood Hits	83	Target Neighborhood Hits	202	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA6_HUMAN
NC score	0.132142 (rank : 47)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	83	Target Neighborhood Hits	556	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.130214 (rank : 48)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	83	Target Neighborhood Hits	591	Shared Neighborhood Hits	49
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CYH3_HUMAN
NC score	0.125988 (rank : 49)	θ value	0.0330416 (rank : 43)
Query Neighborhood Hits	83	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DAPP1_MOUSE
NC score	0.125508 (rank : 50)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	83	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA4_HUMAN
NC score	0.124915 (rank : 51)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	83	Target Neighborhood Hits	283	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH2_HUMAN
NC score	0.124269 (rank : 52)	θ value	0.0961366 (rank : 49)
Query Neighborhood Hits	83	Target Neighborhood Hits	175	Shared Neighborhood Hits	48
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.124161 (rank : 53)	θ value	0.0961366 (rank : 50)
Query Neighborhood Hits	83	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH1_HUMAN
NC score	0.122532 (rank : 54)	θ value	0.813845 (rank : 64)
Query Neighborhood Hits	83	Target Neighborhood Hits	184	Shared Neighborhood Hits	47
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
NC score	0.121122 (rank : 55)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	83	Target Neighborhood Hits	176	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

OPHN1_MOUSE
NC score	0.117982 (rank : 56)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	83	Target Neighborhood Hits	174	Shared Neighborhood Hits	15
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

CYH3_MOUSE
NC score	0.117257 (rank : 57)	θ value	0.125558 (rank : 54)
Query Neighborhood Hits	83	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

PHLB1_MOUSE
NC score	0.115520 (rank : 58)	θ value	0.00298849 (rank : 41)
Query Neighborhood Hits	83	Target Neighborhood Hits	678	Shared Neighborhood Hits	32
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PLEK_HUMAN
NC score	0.109809 (rank : 59)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	83	Target Neighborhood Hits	110	Shared Neighborhood Hits	45
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

OPHN1_HUMAN
NC score	0.107706 (rank : 60)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	83	Target Neighborhood Hits	161	Shared Neighborhood Hits	13
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG25_MOUSE
NC score	0.107676 (rank : 61)	θ value	0.0961366 (rank : 53)
Query Neighborhood Hits	83	Target Neighborhood Hits	492	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

DGKH_HUMAN
NC score	0.107437 (rank : 62)	θ value	0.0431538 (rank : 44)
Query Neighborhood Hits	83	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

CYH4_HUMAN
NC score	0.107012 (rank : 63)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	83	Target Neighborhood Hits	135	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PLEK_MOUSE
NC score	0.106798 (rank : 64)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	83	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

CYH4_MOUSE
NC score	0.105294 (rank : 65)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	83	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

RHG26_HUMAN
NC score	0.104192 (rank : 66)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	83	Target Neighborhood Hits	281	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CT086_HUMAN
NC score	0.101457 (rank : 67)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	83	Target Neighborhood Hits	277	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

RHG25_HUMAN
NC score	0.100157 (rank : 68)	θ value	0.0736092 (rank : 48)
Query Neighborhood Hits	83	Target Neighborhood Hits	550	Shared Neighborhood Hits	44
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

DP13A_HUMAN
NC score	0.099461 (rank : 69)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	83	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
NC score	0.099121 (rank : 70)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	83	Target Neighborhood Hits	96	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_MOUSE
NC score	0.098203 (rank : 71)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	83	Target Neighborhood Hits	58	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

PHLB2_MOUSE
NC score	0.096463 (rank : 72)	θ value	0.00134147 (rank : 39)
Query Neighborhood Hits	83	Target Neighborhood Hits	1016	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
NC score	0.094358 (rank : 73)	θ value	0.00175202 (rank : 40)
Query Neighborhood Hits	83	Target Neighborhood Hits	964	Shared Neighborhood Hits	33
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

DP13B_HUMAN
NC score	0.093016 (rank : 74)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	83	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

PHLB1_HUMAN
NC score	0.092962 (rank : 75)	θ value	0.0961366 (rank : 52)
Query Neighborhood Hits	83	Target Neighborhood Hits	1038	Shared Neighborhood Hits	32
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PKHA5_HUMAN
NC score	0.091878 (rank : 76)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	83	Target Neighborhood Hits	455	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

DGKD_HUMAN
NC score	0.091493 (rank : 77)	θ value	0.365318 (rank : 59)
Query Neighborhood Hits	83	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

ANR46_HUMAN
NC score	0.082969 (rank : 78)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	83	Target Neighborhood Hits	281	Shared Neighborhood Hits	17
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

MTMR5_HUMAN
NC score	0.082604 (rank : 79)	θ value	0.0961366 (rank : 51)
Query Neighborhood Hits	83	Target Neighborhood Hits	141	Shared Neighborhood Hits	32
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

ANR41_HUMAN
NC score	0.082495 (rank : 80)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	83	Target Neighborhood Hits	332	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

MTMRD_HUMAN
NC score	0.082259 (rank : 81)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	83	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

ANR46_MOUSE
NC score	0.081056 (rank : 82)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	83	Target Neighborhood Hits	274	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR37_MOUSE
NC score	0.079792 (rank : 83)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	83	Target Neighborhood Hits	237	Shared Neighborhood Hits	16
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

3BP2_HUMAN
NC score	0.076890 (rank : 84)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	83	Target Neighborhood Hits	296	Shared Neighborhood Hits	34
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANR39_MOUSE
NC score	0.073011 (rank : 85)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_HUMAN
NC score	0.072772 (rank : 86)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	83	Target Neighborhood Hits	285	Shared Neighborhood Hits	18
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

IKBB_MOUSE
NC score	0.072716 (rank : 87)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

ANS4B_MOUSE
NC score	0.071620 (rank : 88)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	83	Target Neighborhood Hits	294	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

GABP3_MOUSE
NC score	0.071005 (rank : 89)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	83	Target Neighborhood Hits	330	Shared Neighborhood Hits	18
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

SWP70_MOUSE
NC score	0.070757 (rank : 90)	θ value	0.62314 (rank : 63)
Query Neighborhood Hits	83	Target Neighborhood Hits	1097	Shared Neighborhood Hits	45
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

3BP2_MOUSE
NC score	0.069915 (rank : 91)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	83	Target Neighborhood Hits	142	Shared Neighborhood Hits	32
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

GABP2_HUMAN
NC score	0.069752 (rank : 92)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	83	Target Neighborhood Hits	454	Shared Neighborhood Hits	20
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

RASA3_HUMAN
NC score	0.069629 (rank : 93)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	83	Target Neighborhood Hits	166	Shared Neighborhood Hits	33
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

GABP2_MOUSE
NC score	0.069436 (rank : 94)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	83	Target Neighborhood Hits	429	Shared Neighborhood Hits	20
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ANR37_HUMAN
NC score	0.069398 (rank : 95)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	83	Target Neighborhood Hits	247	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

SWP70_HUMAN
NC score	0.068796 (rank : 96)	θ value	1.06291 (rank : 67)
Query Neighborhood Hits	83	Target Neighborhood Hits	973	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MTPN_MOUSE
NC score	0.067482 (rank : 97)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	83	Target Neighborhood Hits	269	Shared Neighborhood Hits	16
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

RASA3_MOUSE
NC score	0.067158 (rank : 98)	θ value	0.279714 (rank : 58)
Query Neighborhood Hits	83	Target Neighborhood Hits	144	Shared Neighborhood Hits	31
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

MTPN_HUMAN
NC score	0.065649 (rank : 99)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	83	Target Neighborhood Hits	269	Shared Neighborhood Hits	16
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

ANS4B_HUMAN
NC score	0.065233 (rank : 100)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	83	Target Neighborhood Hits	289	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

CNKR1_HUMAN
NC score	0.065032 (rank : 101)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	83	Target Neighborhood Hits	154	Shared Neighborhood Hits	28
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

RHG09_HUMAN
NC score	0.063770 (rank : 102)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	83	Target Neighborhood Hits	186	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

IKBB_HUMAN
NC score	0.063641 (rank : 103)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

CDN2D_HUMAN
NC score	0.063544 (rank : 104)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	83	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

HECD1_HUMAN
NC score	0.062797 (rank : 105)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	83	Target Neighborhood Hits	371	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

TNKS1_HUMAN
NC score	0.062256 (rank : 106)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	83	Target Neighborhood Hits	477	Shared Neighborhood Hits	25
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANR33_HUMAN
NC score	0.061214 (rank : 107)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	83	Target Neighborhood Hits	215	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

MYPT1_HUMAN
NC score	0.060583 (rank : 108)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	83	Target Neighborhood Hits	723	Shared Neighborhood Hits	22
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

ANKR2_HUMAN
NC score	0.060313 (rank : 109)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	83	Target Neighborhood Hits	321	Shared Neighborhood Hits	18
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

OSBL9_HUMAN
NC score	0.059594 (rank : 110)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	83	Target Neighborhood Hits	138	Shared Neighborhood Hits	39
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

ANR10_HUMAN
NC score	0.059544 (rank : 111)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	83	Target Neighborhood Hits	289	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

MYPT1_MOUSE
NC score	0.059540 (rank : 112)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	83	Target Neighborhood Hits	539	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

RBP1_HUMAN
NC score	0.059352 (rank : 113)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	83	Target Neighborhood Hits	521	Shared Neighborhood Hits	12
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

TNKS2_HUMAN
NC score	0.059253 (rank : 114)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	83	Target Neighborhood Hits	361	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ANKR6_HUMAN
NC score	0.059141 (rank : 115)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	83	Target Neighborhood Hits	439	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ASB10_HUMAN
NC score	0.058810 (rank : 116)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	83	Target Neighborhood Hits	291	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

USH1G_MOUSE
NC score	0.058580 (rank : 117)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	83	Target Neighborhood Hits	271	Shared Neighborhood Hits	18
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ANRA2_MOUSE
NC score	0.058342 (rank : 118)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	83	Target Neighborhood Hits	287	Shared Neighborhood Hits	17
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

USH1G_HUMAN
NC score	0.058301 (rank : 119)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	83	Target Neighborhood Hits	267	Shared Neighborhood Hits	18
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

GAB2_HUMAN
NC score	0.058028 (rank : 120)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	83	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

DGKK_HUMAN
NC score	0.057720 (rank : 121)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	83	Target Neighborhood Hits	378	Shared Neighborhood Hits	23
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

RBP1_MOUSE
NC score	0.057717 (rank : 122)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	83	Target Neighborhood Hits	493	Shared Neighborhood Hits	11
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

ANRA2_HUMAN
NC score	0.057515 (rank : 123)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	83	Target Neighborhood Hits	288	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ANR42_HUMAN
NC score	0.057361 (rank : 124)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

RGAP1_MOUSE
NC score	0.057315 (rank : 125)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	83	Target Neighborhood Hits	185	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GMIP_MOUSE
NC score	0.056880 (rank : 126)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	83	Target Neighborhood Hits	202	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

PSD10_HUMAN
NC score	0.056792 (rank : 127)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	83	Target Neighborhood Hits	301	Shared Neighborhood Hits	18
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANK1_HUMAN
NC score	0.056568 (rank : 128)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	83	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANR10_MOUSE
NC score	0.056547 (rank : 129)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	83	Target Neighborhood Hits	273	Shared Neighborhood Hits	18
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR52_MOUSE
NC score	0.056515 (rank : 130)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	83	Target Neighborhood Hits	318	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_HUMAN
NC score	0.056421 (rank : 131)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	83	Target Neighborhood Hits	322	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

RHG06_HUMAN
NC score	0.056380 (rank : 132)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	83	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

ANK1_MOUSE
NC score	0.056319 (rank : 133)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	83	Target Neighborhood Hits	430	Shared Neighborhood Hits	18
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

RHG06_MOUSE
NC score	0.056280 (rank : 134)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	83	Target Neighborhood Hits	105	Shared Neighborhood Hits	8
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

ASB8_HUMAN
NC score	0.056202 (rank : 135)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	83	Target Neighborhood Hits	294	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ASB10_MOUSE
NC score	0.056135 (rank : 136)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	83	Target Neighborhood Hits	301	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ANKR1_MOUSE
NC score	0.056057 (rank : 137)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	83	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

RASA2_HUMAN
NC score	0.056038 (rank : 138)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	83	Target Neighborhood Hits	157	Shared Neighborhood Hits	24
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

TCGAP_HUMAN
NC score	0.055979 (rank : 139)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	83	Target Neighborhood Hits	872	Shared Neighborhood Hits	14
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ASB8_MOUSE
NC score	0.055744 (rank : 140)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	83	Target Neighborhood Hits	293	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

RGAP1_HUMAN
NC score	0.055633 (rank : 141)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	83	Target Neighborhood Hits	189	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RAI14_HUMAN
NC score	0.055565 (rank : 142)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	83	Target Neighborhood Hits	1367	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

PSD10_MOUSE
NC score	0.055557 (rank : 143)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	83	Target Neighborhood Hits	293	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR35_HUMAN
NC score	0.055465 (rank : 144)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	83	Target Neighborhood Hits	784	Shared Neighborhood Hits	21
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

ANKR2_MOUSE
NC score	0.055150 (rank : 145)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	83	Target Neighborhood Hits	312	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

ANR23_HUMAN
NC score	0.055029 (rank : 146)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	83	Target Neighborhood Hits	291	Shared Neighborhood Hits	18
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

RHG05_MOUSE
NC score	0.054830 (rank : 147)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	83	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG18_HUMAN
NC score	0.054774 (rank : 148)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	83	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

TAGAP_HUMAN
NC score	0.054766 (rank : 149)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	83	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

ANKR1_HUMAN
NC score	0.054693 (rank : 150)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	83	Target Neighborhood Hits	308	Shared Neighborhood Hits	18
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ANR22_HUMAN
NC score	0.054554 (rank : 151)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	83	Target Neighborhood Hits	243	Shared Neighborhood Hits	10
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

BCL3_MOUSE
NC score	0.054410 (rank : 152)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	83	Target Neighborhood Hits	388	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

PA2G6_HUMAN
NC score	0.054233 (rank : 153)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	83	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

OSBP1_HUMAN
NC score	0.054176 (rank : 154)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	83	Target Neighborhood Hits	180	Shared Neighborhood Hits	40
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

BCL3_HUMAN
NC score	0.054152 (rank : 155)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	83	Target Neighborhood Hits	324	Shared Neighborhood Hits	19
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

RHG05_HUMAN
NC score	0.054121 (rank : 156)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	83	Target Neighborhood Hits	158	Shared Neighborhood Hits	7
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

BCR_HUMAN
NC score	0.053969 (rank : 157)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	83	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ACBD6_HUMAN
NC score	0.053909 (rank : 158)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	83	Target Neighborhood Hits	304	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

CDN2D_MOUSE
NC score	0.053872 (rank : 159)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	83	Target Neighborhood Hits	267	Shared Neighborhood Hits	13
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ANR42_MOUSE
NC score	0.053160 (rank : 160)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	83	Target Neighborhood Hits	334	Shared Neighborhood Hits	18
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

BARD1_HUMAN
NC score	0.053115 (rank : 161)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	83	Target Neighborhood Hits	427	Shared Neighborhood Hits	18
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ANR44_HUMAN
NC score	0.053046 (rank : 162)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	83	Target Neighborhood Hits	318	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ABR_HUMAN
NC score	0.053032 (rank : 163)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	83	Target Neighborhood Hits	166	Shared Neighborhood Hits	10
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ANR50_HUMAN
NC score	0.053027 (rank : 164)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	83	Target Neighborhood Hits	361	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

GMIP_HUMAN
NC score	0.053026 (rank : 165)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	83	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

CSKI2_HUMAN
NC score	0.052962 (rank : 166)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	83	Target Neighborhood Hits	747	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

RHG12_MOUSE
NC score	0.052959 (rank : 167)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	83	Target Neighborhood Hits	204	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG18_MOUSE
NC score	0.052452 (rank : 168)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	83	Target Neighborhood Hits	110	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

ACBD6_MOUSE
NC score	0.052429 (rank : 169)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	83	Target Neighborhood Hits	305	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

MYPT2_HUMAN
NC score	0.052277 (rank : 170)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	83	Target Neighborhood Hits	707	Shared Neighborhood Hits	17
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

ANR23_MOUSE
NC score	0.052256 (rank : 171)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	83	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

GAB2_MOUSE
NC score	0.052155 (rank : 172)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	83	Target Neighborhood Hits	220	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

CSKI2_MOUSE
NC score	0.052042 (rank : 173)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	83	Target Neighborhood Hits	812	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ANKR5_MOUSE
NC score	0.051855 (rank : 174)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	83	Target Neighborhood Hits	298	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

PP16A_MOUSE
NC score	0.051840 (rank : 175)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	83	Target Neighborhood Hits	318	Shared Neighborhood Hits	17
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

ANKR5_HUMAN
NC score	0.051799 (rank : 176)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	83	Target Neighborhood Hits	297	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANR49_HUMAN
NC score	0.051752 (rank : 177)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	83	Target Neighborhood Hits	282	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

EHMT2_HUMAN
NC score	0.051707 (rank : 178)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	83	Target Neighborhood Hits	498	Shared Neighborhood Hits	19
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ANR28_MOUSE
NC score	0.051697 (rank : 179)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	83	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

TAGAP_MOUSE
NC score	0.051621 (rank : 180)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	83	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

GRLF1_HUMAN
NC score	0.051554 (rank : 181)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	83	Target Neighborhood Hits	167	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

SHAN1_HUMAN
NC score	0.051490 (rank : 182)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	83	Target Neighborhood Hits	1041	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

RHG12_HUMAN
NC score	0.051478 (rank : 183)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	83	Target Neighborhood Hits	190	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TCGAP_MOUSE
NC score	0.051406 (rank : 184)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	83	Target Neighborhood Hits	409	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ANR15_HUMAN
NC score	0.051392 (rank : 185)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	83	Target Neighborhood Hits	478	Shared Neighborhood Hits	20
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ASB3_MOUSE
NC score	0.051277 (rank : 186)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	83	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

GAB1_HUMAN
NC score	0.051273 (rank : 187)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	83	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CSKI1_MOUSE
NC score	0.051239 (rank : 188)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	83	Target Neighborhood Hits	1031	Shared Neighborhood Hits	26
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

RAI14_MOUSE
NC score	0.051218 (rank : 189)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	83	Target Neighborhood Hits	1505	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

AN13B_MOUSE
NC score	0.051191 (rank : 190)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	83	Target Neighborhood Hits	276	Shared Neighborhood Hits	15
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

ANR28_HUMAN
NC score	0.051179 (rank : 191)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	83	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

AN13B_HUMAN
NC score	0.051117 (rank : 192)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	83	Target Neighborhood Hits	265	Shared Neighborhood Hits	15
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

CSKI1_HUMAN
NC score	0.051094 (rank : 193)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	83	Target Neighborhood Hits	997	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ASB12_MOUSE
NC score	0.050902 (rank : 194)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	83	Target Neighborhood Hits	261	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB12_HUMAN
NC score	0.050845 (rank : 195)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	83	Target Neighborhood Hits	263	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

BARD1_MOUSE
NC score	0.050768 (rank : 196)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	83	Target Neighborhood Hits	411	Shared Neighborhood Hits	18
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

RASA2_MOUSE
NC score	0.050758 (rank : 197)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	83	Target Neighborhood Hits	159	Shared Neighborhood Hits	25
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

ANR33_MOUSE
NC score	0.050663 (rank : 198)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	83	Target Neighborhood Hits	225	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

DGKI_HUMAN
NC score	0.050485 (rank : 199)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	83	Target Neighborhood Hits	609	Shared Neighborhood Hits	17
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

ASB7_MOUSE
NC score	0.050314 (rank : 200)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	83	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB16_HUMAN
NC score	0.050298 (rank : 201)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	83	Target Neighborhood Hits	286	Shared Neighborhood Hits	18
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ASB7_HUMAN
NC score	0.050296 (rank : 202)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	83	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

GNRP_HUMAN
NC score	0.046328 (rank : 203)	θ value	1.81305 (rank : 69)
Query Neighborhood Hits	83	Target Neighborhood Hits	239	Shared Neighborhood Hits	29
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
NC score	0.043776 (rank : 204)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	83	Target Neighborhood Hits	191	Shared Neighborhood Hits	29
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

OSB10_HUMAN
NC score	0.042279 (rank : 205)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	83	Target Neighborhood Hits	55	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

FGD6_HUMAN
NC score	0.022268 (rank : 206)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	83	Target Neighborhood Hits	237	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ALS2_HUMAN
NC score	0.017947 (rank : 207)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	83	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
NC score	0.017934 (rank : 208)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	83	Target Neighborhood Hits	111	Shared Neighborhood Hits	8
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

MLE3_MOUSE
NC score	0.017000 (rank : 209)	θ value	1.81305 (rank : 71)
Query Neighborhood Hits	83	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	P05978	Gene names	Myl1, Mylf
Domain Architecture
Description	Myosin light chain 3, skeletal muscle isoform (A2 catalytic) (Alkali myosin light chain 3) (MLC3F).

MLE1_MOUSE
NC score	0.016853 (rank : 210)	θ value	1.81305 (rank : 70)
Query Neighborhood Hits	83	Target Neighborhood Hits	69	Shared Neighborhood Hits	5
SwissProt Accessions	P05977	Gene names	Myl1, Mylf
Domain Architecture
Description	Myosin light chain 1, skeletal muscle isoform (MLC1F) (A1 catalytic) (Alkali myosin light chain 1).

MLE3_HUMAN
NC score	0.013136 (rank : 211)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	83	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	P06741	Gene names	MYL1
Domain Architecture
Description	Myosin light chain 3, skeletal muscle isoform (A2 catalytic) (Alkali myosin light chain 3) (MLC3F).

MLE1_HUMAN
NC score	0.013105 (rank : 212)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	83	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	P05976	Gene names	MYL1
Domain Architecture
Description	Myosin light chain 1, skeletal muscle isoform (MLC1F) (A1 catalytic) (Alkali myosin light chain 1).