Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : FGD6_HUMAN

For an explanation of this page, click here

FGD6_HUMAN
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	237	Target Neighborhood Hits	237	Shared Neighborhood Hits	237
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	0 (rank : 2)	NC score	0.984160 (rank : 2)
Query Neighborhood Hits	237	Target Neighborhood Hits	282	Shared Neighborhood Hits	162
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD5_HUMAN
θ value	9.24197e-138 (rank : 3)	NC score	0.906746 (rank : 3)
Query Neighborhood Hits	237	Target Neighborhood Hits	235	Shared Neighborhood Hits	116
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	2.52267e-127 (rank : 4)	NC score	0.902333 (rank : 6)
Query Neighborhood Hits	237	Target Neighborhood Hits	170	Shared Neighborhood Hits	112
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD4_MOUSE
θ value	1.2268e-81 (rank : 5)	NC score	0.896103 (rank : 8)
Query Neighborhood Hits	237	Target Neighborhood Hits	227	Shared Neighborhood Hits	128
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
θ value	2.73302e-81 (rank : 6)	NC score	0.899175 (rank : 7)
Query Neighborhood Hits	237	Target Neighborhood Hits	219	Shared Neighborhood Hits	129
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD1_MOUSE
θ value	8.51556e-75 (rank : 7)	NC score	0.882612 (rank : 10)
Query Neighborhood Hits	237	Target Neighborhood Hits	387	Shared Neighborhood Hits	116
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	1.11217e-74 (rank : 8)	NC score	0.903855 (rank : 5)
Query Neighborhood Hits	237	Target Neighborhood Hits	151	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD1_HUMAN
θ value	4.22625e-74 (rank : 9)	NC score	0.884692 (rank : 9)
Query Neighborhood Hits	237	Target Neighborhood Hits	367	Shared Neighborhood Hits	118
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_MOUSE
θ value	9.41505e-74 (rank : 10)	NC score	0.905840 (rank : 4)
Query Neighborhood Hits	237	Target Neighborhood Hits	163	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	1.08223e-53 (rank : 11)	NC score	0.868451 (rank : 11)
Query Neighborhood Hits	237	Target Neighborhood Hits	249	Shared Neighborhood Hits	107
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	3.48141e-52 (rank : 12)	NC score	0.860615 (rank : 12)
Query Neighborhood Hits	237	Target Neighborhood Hits	257	Shared Neighborhood Hits	117
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FARP2_MOUSE
θ value	9.50281e-42 (rank : 13)	NC score	0.553023 (rank : 29)
Query Neighborhood Hits	237	Target Neighborhood Hits	209	Shared Neighborhood Hits	99
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	6.15952e-41 (rank : 14)	NC score	0.542723 (rank : 33)
Query Neighborhood Hits	237	Target Neighborhood Hits	240	Shared Neighborhood Hits	95
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
θ value	2.86122e-38 (rank : 15)	NC score	0.517822 (rank : 38)
Query Neighborhood Hits	237	Target Neighborhood Hits	241	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHF1_HUMAN
θ value	1.08979e-29 (rank : 16)	NC score	0.733015 (rank : 15)
Query Neighborhood Hits	237	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	4.14116e-29 (rank : 17)	NC score	0.731069 (rank : 16)
Query Neighborhood Hits	237	Target Neighborhood Hits	80	Shared Neighborhood Hits	58
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	3.50572e-28 (rank : 18)	NC score	0.733771 (rank : 13)
Query Neighborhood Hits	237	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	4.57862e-28 (rank : 19)	NC score	0.733211 (rank : 14)
Query Neighborhood Hits	237	Target Neighborhood Hits	77	Shared Neighborhood Hits	64
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ECT2_MOUSE
θ value	3.88503e-19 (rank : 20)	NC score	0.646946 (rank : 17)
Query Neighborhood Hits	237	Target Neighborhood Hits	98	Shared Neighborhood Hits	66
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ITSN1_HUMAN
θ value	1.13037e-18 (rank : 21)	NC score	0.350201 (rank : 84)
Query Neighborhood Hits	237	Target Neighborhood Hits	1757	Shared Neighborhood Hits	103
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ECT2_HUMAN
θ value	1.47631e-18 (rank : 22)	NC score	0.633325 (rank : 18)
Query Neighborhood Hits	237	Target Neighborhood Hits	98	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ITSN1_MOUSE
θ value	5.60996e-18 (rank : 23)	NC score	0.349653 (rank : 85)
Query Neighborhood Hits	237	Target Neighborhood Hits	1669	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PREX1_HUMAN
θ value	1.63225e-17 (rank : 24)	NC score	0.630271 (rank : 19)
Query Neighborhood Hits	237	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ZFY16_MOUSE
θ value	1.63225e-17 (rank : 25)	NC score	0.553287 (rank : 28)
Query Neighborhood Hits	237	Target Neighborhood Hits	108	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

PKHG1_HUMAN
θ value	3.63628e-17 (rank : 26)	NC score	0.599835 (rank : 20)
Query Neighborhood Hits	237	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ZFY16_HUMAN
θ value	1.38178e-16 (rank : 27)	NC score	0.545512 (rank : 32)
Query Neighborhood Hits	237	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ARHGA_HUMAN
θ value	3.07829e-16 (rank : 28)	NC score	0.569054 (rank : 22)
Query Neighborhood Hits	237	Target Neighborhood Hits	187	Shared Neighborhood Hits	66
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	4.02038e-16 (rank : 29)	NC score	0.566680 (rank : 24)
Query Neighborhood Hits	237	Target Neighborhood Hits	125	Shared Neighborhood Hits	60
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ZFYV9_HUMAN
θ value	4.02038e-16 (rank : 30)	NC score	0.564634 (rank : 25)
Query Neighborhood Hits	237	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

BCR_HUMAN
θ value	1.16975e-15 (rank : 31)	NC score	0.409511 (rank : 61)
Query Neighborhood Hits	237	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ITSN2_HUMAN
θ value	1.52774e-15 (rank : 32)	NC score	0.375465 (rank : 71)
Query Neighborhood Hits	237	Target Neighborhood Hits	1173	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	5.8054e-15 (rank : 33)	NC score	0.360896 (rank : 77)
Query Neighborhood Hits	237	Target Neighborhood Hits	1371	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ZFY28_HUMAN
θ value	9.26847e-13 (rank : 34)	NC score	0.572850 (rank : 21)
Query Neighborhood Hits	237	Target Neighborhood Hits	152	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ABR_HUMAN
θ value	2.0648e-12 (rank : 35)	NC score	0.403801 (rank : 63)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG4_HUMAN
θ value	3.52202e-12 (rank : 36)	NC score	0.529683 (rank : 37)
Query Neighborhood Hits	237	Target Neighborhood Hits	242	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

GNRP_MOUSE
θ value	3.52202e-12 (rank : 37)	NC score	0.455597 (rank : 49)
Query Neighborhood Hits	237	Target Neighborhood Hits	191	Shared Neighborhood Hits	86
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RUFY2_MOUSE
θ value	3.52202e-12 (rank : 38)	NC score	0.322692 (rank : 89)
Query Neighborhood Hits	237	Target Neighborhood Hits	820	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

TRIO_HUMAN
θ value	6.00763e-12 (rank : 39)	NC score	0.185738 (rank : 115)
Query Neighborhood Hits	237	Target Neighborhood Hits	1580	Shared Neighborhood Hits	92
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DUET_HUMAN
θ value	7.84624e-12 (rank : 40)	NC score	0.192912 (rank : 113)
Query Neighborhood Hits	237	Target Neighborhood Hits	1220	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

RUFY2_HUMAN
θ value	1.74796e-11 (rank : 41)	NC score	0.264468 (rank : 100)
Query Neighborhood Hits	237	Target Neighborhood Hits	1208	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

GNRP_HUMAN
θ value	2.28291e-11 (rank : 42)	NC score	0.427581 (rank : 53)
Query Neighborhood Hits	237	Target Neighborhood Hits	239	Shared Neighborhood Hits	88
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RUFY1_HUMAN
θ value	3.89403e-11 (rank : 43)	NC score	0.313794 (rank : 94)
Query Neighborhood Hits	237	Target Neighborhood Hits	848	Shared Neighborhood Hits	71
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY3_HUMAN
θ value	5.08577e-11 (rank : 44)	NC score	0.316044 (rank : 92)
Query Neighborhood Hits	237	Target Neighborhood Hits	348	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	5.08577e-11 (rank : 45)	NC score	0.316497 (rank : 91)
Query Neighborhood Hits	237	Target Neighborhood Hits	332	Shared Neighborhood Hits	52
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

EEA1_HUMAN
θ value	8.67504e-11 (rank : 46)	NC score	0.194866 (rank : 112)
Query Neighborhood Hits	237	Target Neighborhood Hits	1796	Shared Neighborhood Hits	97
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

NGEF_MOUSE
θ value	8.67504e-11 (rank : 47)	NC score	0.536746 (rank : 35)
Query Neighborhood Hits	237	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG5_HUMAN
θ value	1.133e-10 (rank : 48)	NC score	0.567467 (rank : 23)
Query Neighborhood Hits	237	Target Neighborhood Hits	172	Shared Neighborhood Hits	68
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_HUMAN
θ value	1.133e-10 (rank : 49)	NC score	0.548332 (rank : 31)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG4_MOUSE
θ value	1.47974e-10 (rank : 50)	NC score	0.538763 (rank : 34)
Query Neighborhood Hits	237	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

MTMR3_HUMAN
θ value	1.9326e-10 (rank : 51)	NC score	0.315922 (rank : 93)
Query Neighborhood Hits	237	Target Neighborhood Hits	163	Shared Neighborhood Hits	52
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY1_MOUSE
θ value	1.9326e-10 (rank : 52)	NC score	0.317997 (rank : 90)
Query Neighborhood Hits	237	Target Neighborhood Hits	765	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

EEA1_MOUSE
θ value	2.52405e-10 (rank : 53)	NC score	0.207067 (rank : 110)
Query Neighborhood Hits	237	Target Neighborhood Hits	1637	Shared Neighborhood Hits	92
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

ZFY21_HUMAN
θ value	4.30538e-10 (rank : 54)	NC score	0.556809 (rank : 27)
Query Neighborhood Hits	237	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	5.62301e-10 (rank : 55)	NC score	0.561424 (rank : 26)
Query Neighborhood Hits	237	Target Neighborhood Hits	72	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FYCO1_HUMAN
θ value	1.25267e-09 (rank : 56)	NC score	0.226423 (rank : 104)
Query Neighborhood Hits	237	Target Neighborhood Hits	1149	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

HAPIP_HUMAN
θ value	1.25267e-09 (rank : 57)	NC score	0.460344 (rank : 46)
Query Neighborhood Hits	237	Target Neighborhood Hits	350	Shared Neighborhood Hits	80
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

VAV3_HUMAN
θ value	1.63604e-09 (rank : 58)	NC score	0.357255 (rank : 80)
Query Neighborhood Hits	237	Target Neighborhood Hits	398	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

MCF2_HUMAN
θ value	4.76016e-09 (rank : 59)	NC score	0.504244 (rank : 42)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

VAV3_MOUSE
θ value	4.76016e-09 (rank : 60)	NC score	0.358031 (rank : 79)
Query Neighborhood Hits	237	Target Neighborhood Hits	404	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG9_HUMAN
θ value	6.21693e-09 (rank : 61)	NC score	0.511693 (rank : 39)
Query Neighborhood Hits	237	Target Neighborhood Hits	235	Shared Neighborhood Hits	68
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ANFY1_MOUSE
θ value	8.11959e-09 (rank : 62)	NC score	0.209204 (rank : 106)
Query Neighborhood Hits	237	Target Neighborhood Hits	480	Shared Neighborhood Hits	59
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
θ value	1.06045e-08 (rank : 63)	NC score	0.208742 (rank : 108)
Query Neighborhood Hits	237	Target Neighborhood Hits	480	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

HGS_MOUSE
θ value	1.38499e-08 (rank : 64)	NC score	0.421969 (rank : 56)
Query Neighborhood Hits	237	Target Neighborhood Hits	589	Shared Neighborhood Hits	63
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

ARHGG_MOUSE
θ value	1.80886e-08 (rank : 65)	NC score	0.535029 (rank : 36)
Query Neighborhood Hits	237	Target Neighborhood Hits	152	Shared Neighborhood Hits	64
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG9_MOUSE
θ value	3.08544e-08 (rank : 66)	NC score	0.509466 (rank : 40)
Query Neighborhood Hits	237	Target Neighborhood Hits	234	Shared Neighborhood Hits	68
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

HGS_HUMAN
θ value	4.0297e-08 (rank : 67)	NC score	0.421962 (rank : 57)
Query Neighborhood Hits	237	Target Neighborhood Hits	517	Shared Neighborhood Hits	62
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ARHGG_HUMAN
θ value	6.87365e-08 (rank : 68)	NC score	0.548788 (rank : 30)
Query Neighborhood Hits	237	Target Neighborhood Hits	129	Shared Neighborhood Hits	64
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2L_MOUSE
θ value	6.87365e-08 (rank : 69)	NC score	0.479864 (rank : 43)
Query Neighborhood Hits	237	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FYV1_HUMAN
θ value	8.97725e-08 (rank : 70)	NC score	0.374256 (rank : 73)
Query Neighborhood Hits	237	Target Neighborhood Hits	217	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	1.17247e-07 (rank : 71)	NC score	0.370704 (rank : 74)
Query Neighborhood Hits	237	Target Neighborhood Hits	191	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ARHG8_MOUSE
θ value	1.99992e-07 (rank : 72)	NC score	0.387132 (rank : 68)
Query Neighborhood Hits	237	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGF_HUMAN
θ value	1.99992e-07 (rank : 73)	NC score	0.507111 (rank : 41)
Query Neighborhood Hits	237	Target Neighborhood Hits	214	Shared Neighborhood Hits	63
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

VAV_MOUSE
θ value	1.99992e-07 (rank : 74)	NC score	0.374520 (rank : 72)
Query Neighborhood Hits	237	Target Neighborhood Hits	430	Shared Neighborhood Hits	69
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG1_HUMAN
θ value	3.41135e-07 (rank : 75)	NC score	0.456526 (rank : 48)
Query Neighborhood Hits	237	Target Neighborhood Hits	176	Shared Neighborhood Hits	61
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG8_HUMAN
θ value	4.45536e-07 (rank : 76)	NC score	0.454729 (rank : 50)
Query Neighborhood Hits	237	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

PKHA6_MOUSE
θ value	4.45536e-07 (rank : 77)	NC score	0.246002 (rank : 102)
Query Neighborhood Hits	237	Target Neighborhood Hits	591	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

FYCO1_MOUSE
θ value	5.81887e-07 (rank : 78)	NC score	0.208854 (rank : 107)
Query Neighborhood Hits	237	Target Neighborhood Hits	1059	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ZFYV1_HUMAN
θ value	5.81887e-07 (rank : 79)	NC score	0.423141 (rank : 55)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

PKHA6_HUMAN
θ value	7.59969e-07 (rank : 80)	NC score	0.249239 (rank : 101)
Query Neighborhood Hits	237	Target Neighborhood Hits	556	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARHG1_MOUSE
θ value	1.69304e-06 (rank : 81)	NC score	0.435148 (rank : 51)
Query Neighborhood Hits	237	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ZFY19_HUMAN
θ value	1.69304e-06 (rank : 82)	NC score	0.379755 (rank : 69)
Query Neighborhood Hits	237	Target Neighborhood Hits	206	Shared Neighborhood Hits	48
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

VAV_HUMAN
θ value	2.21117e-06 (rank : 83)	NC score	0.369208 (rank : 75)
Query Neighborhood Hits	237	Target Neighborhood Hits	452	Shared Neighborhood Hits	68
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ZFYV1_MOUSE
θ value	2.21117e-06 (rank : 84)	NC score	0.418184 (rank : 58)
Query Neighborhood Hits	237	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

TIAM1_HUMAN
θ value	6.43352e-06 (rank : 85)	NC score	0.469432 (rank : 44)
Query Neighborhood Hits	237	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG2_MOUSE
θ value	1.09739e-05 (rank : 86)	NC score	0.457170 (rank : 47)
Query Neighborhood Hits	237	Target Neighborhood Hits	120	Shared Neighborhood Hits	58
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

OBSCN_HUMAN
θ value	1.43324e-05 (rank : 87)	NC score	0.087676 (rank : 143)
Query Neighborhood Hits	237	Target Neighborhood Hits	1931	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

VAV2_MOUSE
θ value	2.44474e-05 (rank : 88)	NC score	0.360810 (rank : 78)
Query Neighborhood Hits	237	Target Neighborhood Hits	456	Shared Neighborhood Hits	73
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

PKHG4_HUMAN
θ value	3.19293e-05 (rank : 89)	NC score	0.425930 (rank : 54)
Query Neighborhood Hits	237	Target Neighborhood Hits	200	Shared Neighborhood Hits	50
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

TIAM1_MOUSE
θ value	7.1131e-05 (rank : 90)	NC score	0.467731 (rank : 45)
Query Neighborhood Hits	237	Target Neighborhood Hits	205	Shared Neighborhood Hits	80
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ALS2_MOUSE
θ value	9.29e-05 (rank : 91)	NC score	0.158432 (rank : 119)
Query Neighborhood Hits	237	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

RBNS5_HUMAN
θ value	9.29e-05 (rank : 92)	NC score	0.394525 (rank : 66)
Query Neighborhood Hits	237	Target Neighborhood Hits	242	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	9.29e-05 (rank : 93)	NC score	0.387781 (rank : 67)
Query Neighborhood Hits	237	Target Neighborhood Hits	266	Shared Neighborhood Hits	55
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ARHGB_HUMAN
θ value	0.000121331 (rank : 94)	NC score	0.434510 (rank : 52)
Query Neighborhood Hits	237	Target Neighborhood Hits	375	Shared Neighborhood Hits	68
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	0.000158464 (rank : 95)	NC score	0.403252 (rank : 64)
Query Neighborhood Hits	237	Target Neighborhood Hits	351	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ZFY19_MOUSE
θ value	0.000158464 (rank : 96)	NC score	0.363549 (rank : 76)
Query Neighborhood Hits	237	Target Neighborhood Hits	143	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

RGNEF_MOUSE
θ value	0.00020696 (rank : 97)	NC score	0.330728 (rank : 88)
Query Neighborhood Hits	237	Target Neighborhood Hits	641	Shared Neighborhood Hits	72
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

WDFY1_HUMAN
θ value	0.00020696 (rank : 98)	NC score	0.305434 (rank : 95)
Query Neighborhood Hits	237	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

VAV2_HUMAN
θ value	0.000270298 (rank : 99)	NC score	0.351614 (rank : 83)
Query Neighborhood Hits	237	Target Neighborhood Hits	453	Shared Neighborhood Hits	72
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHGC_MOUSE
θ value	0.000461057 (rank : 100)	NC score	0.398449 (rank : 65)
Query Neighborhood Hits	237	Target Neighborhood Hits	344	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ALS2_HUMAN
θ value	0.00102713 (rank : 101)	NC score	0.142912 (rank : 121)
Query Neighborhood Hits	237	Target Neighborhood Hits	121	Shared Neighborhood Hits	23
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

WDFY2_HUMAN
θ value	0.00102713 (rank : 102)	NC score	0.281404 (rank : 98)
Query Neighborhood Hits	237	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	0.00102713 (rank : 103)	NC score	0.283602 (rank : 97)
Query Neighborhood Hits	237	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

MTMRD_HUMAN
θ value	0.00134147 (rank : 104)	NC score	0.089113 (rank : 139)
Query Neighborhood Hits	237	Target Neighborhood Hits	135	Shared Neighborhood Hits	43
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

EXOC8_HUMAN
θ value	0.00175202 (rank : 105)	NC score	0.076465 (rank : 158)
Query Neighborhood Hits	237	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IYI6, Q5TE82	Gene names	EXOC8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

PKHA5_HUMAN
θ value	0.00228821 (rank : 106)	NC score	0.185605 (rank : 116)
Query Neighborhood Hits	237	Target Neighborhood Hits	455	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CNKR2_HUMAN
θ value	0.00298849 (rank : 107)	NC score	0.138328 (rank : 123)
Query Neighborhood Hits	237	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.00298849 (rank : 108)	NC score	0.138812 (rank : 122)
Query Neighborhood Hits	237	Target Neighborhood Hits	197	Shared Neighborhood Hits	37
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DNMBP_HUMAN
θ value	0.00298849 (rank : 109)	NC score	0.341357 (rank : 86)
Query Neighborhood Hits	237	Target Neighborhood Hits	413	Shared Neighborhood Hits	77
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PKHA3_HUMAN
θ value	0.00298849 (rank : 110)	NC score	0.110838 (rank : 126)
Query Neighborhood Hits	237	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

MTMR5_HUMAN
θ value	0.00509761 (rank : 111)	NC score	0.078053 (rank : 155)
Query Neighborhood Hits	237	Target Neighborhood Hits	141	Shared Neighborhood Hits	39
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

DNMBP_MOUSE
θ value	0.00665767 (rank : 112)	NC score	0.354661 (rank : 82)
Query Neighborhood Hits	237	Target Neighborhood Hits	435	Shared Neighborhood Hits	69
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LBC_HUMAN
θ value	0.00665767 (rank : 113)	NC score	0.404113 (rank : 62)
Query Neighborhood Hits	237	Target Neighborhood Hits	90	Shared Neighborhood Hits	52
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

PKHA3_MOUSE
θ value	0.00665767 (rank : 114)	NC score	0.110568 (rank : 127)
Query Neighborhood Hits	237	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

OSBL9_HUMAN
θ value	0.0193708 (rank : 115)	NC score	0.102283 (rank : 129)
Query Neighborhood Hits	237	Target Neighborhood Hits	138	Shared Neighborhood Hits	43
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

SWP70_MOUSE
θ value	0.0252991 (rank : 116)	NC score	0.117111 (rank : 125)
Query Neighborhood Hits	237	Target Neighborhood Hits	1097	Shared Neighborhood Hits	91
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CNKR1_HUMAN
θ value	0.0330416 (rank : 117)	NC score	0.145195 (rank : 120)
Query Neighborhood Hits	237	Target Neighborhood Hits	154	Shared Neighborhood Hits	35
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

SWP70_HUMAN
θ value	0.0330416 (rank : 118)	NC score	0.120594 (rank : 124)
Query Neighborhood Hits	237	Target Neighborhood Hits	973	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GOGA3_MOUSE
θ value	0.0431538 (rank : 119)	NC score	0.060366 (rank : 198)
Query Neighborhood Hits	237	Target Neighborhood Hits	1437	Shared Neighborhood Hits	53
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

PLEK2_HUMAN
θ value	0.0563607 (rank : 120)	NC score	0.075021 (rank : 161)
Query Neighborhood Hits	237	Target Neighborhood Hits	101	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

CYH4_MOUSE
θ value	0.0736092 (rank : 121)	NC score	0.102054 (rank : 130)
Query Neighborhood Hits	237	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH3_MOUSE
θ value	0.125558 (rank : 122)	NC score	0.108193 (rank : 128)
Query Neighborhood Hits	237	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_HUMAN
θ value	0.125558 (rank : 123)	NC score	0.095955 (rank : 131)
Query Neighborhood Hits	237	Target Neighborhood Hits	135	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

DDFL1_HUMAN
θ value	0.125558 (rank : 124)	NC score	0.033727 (rank : 273)
Query Neighborhood Hits	237	Target Neighborhood Hits	353	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DSPP_HUMAN
θ value	0.125558 (rank : 125)	NC score	0.035799 (rank : 272)
Query Neighborhood Hits	237	Target Neighborhood Hits	645	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

NPHP3_MOUSE
θ value	0.125558 (rank : 126)	NC score	0.023808 (rank : 287)
Query Neighborhood Hits	237	Target Neighborhood Hits	335	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TNH6, Q69Z39, Q8C798, Q8C7Z3, Q9D6D1	Gene names	Nphp3, Kiaa2000
Domain Architecture	No domain graphic available
Description	Nephrocystin-3.

PLEK2_MOUSE
θ value	0.125558 (rank : 127)	NC score	0.075675 (rank : 159)
Query Neighborhood Hits	237	Target Neighborhood Hits	96	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

DSPP_MOUSE
θ value	0.163984 (rank : 128)	NC score	0.035944 (rank : 271)
Query Neighborhood Hits	237	Target Neighborhood Hits	491	Shared Neighborhood Hits	22
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

SPTB2_HUMAN
θ value	0.163984 (rank : 129)	NC score	0.044693 (rank : 265)
Query Neighborhood Hits	237	Target Neighborhood Hits	748	Shared Neighborhood Hits	49
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

FSTL1_MOUSE
θ value	0.21417 (rank : 130)	NC score	0.041294 (rank : 268)
Query Neighborhood Hits	237	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

SP100_HUMAN
θ value	0.21417 (rank : 131)	NC score	0.014788 (rank : 301)
Query Neighborhood Hits	237	Target Neighborhood Hits	117	Shared Neighborhood Hits	2
SwissProt Accessions	P23497, O75450, Q13343, Q96F70, Q96T24, Q96T95, Q9NP33, Q9UE32	Gene names	SP100
Domain Architecture
Description	Nuclear autoantigen Sp-100 (Speckled 100 kDa) (Nuclear dot-associated Sp100 protein) (Lysp100b).

FSTL1_HUMAN
θ value	0.279714 (rank : 132)	NC score	0.040297 (rank : 269)
Query Neighborhood Hits	237	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

SFRS4_HUMAN
θ value	0.279714 (rank : 133)	NC score	0.009520 (rank : 316)
Query Neighborhood Hits	237	Target Neighborhood Hits	384	Shared Neighborhood Hits	11
SwissProt Accessions	Q08170, Q5VXP1, Q9BUA4, Q9UEB5	Gene names	SFRS4, SRP75
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB).

HUWE1_MOUSE
θ value	0.365318 (rank : 134)	NC score	0.013104 (rank : 305)
Query Neighborhood Hits	237	Target Neighborhood Hits	406	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

IQEC3_HUMAN
θ value	0.365318 (rank : 135)	NC score	0.058421 (rank : 205)
Query Neighborhood Hits	237	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

TNR25_HUMAN
θ value	0.365318 (rank : 136)	NC score	0.030151 (rank : 280)
Query Neighborhood Hits	237	Target Neighborhood Hits	172	Shared Neighborhood Hits	4
SwissProt Accessions	Q93038, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5	Gene names	TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 25 precursor (WSL-1 protein) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death domain receptor 3) (WSL protein) (Apoptosis- inducing receptor AIR) (Apo-3) (Lymphocyte-associated receptor of death) (LARD).

CJ006_MOUSE
θ value	0.47712 (rank : 137)	NC score	0.022523 (rank : 290)
Query Neighborhood Hits	237	Target Neighborhood Hits	141	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

ITK_HUMAN
θ value	0.47712 (rank : 138)	NC score	0.007081 (rank : 326)
Query Neighborhood Hits	237	Target Neighborhood Hits	1016	Shared Neighborhood Hits	40
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

K2002_MOUSE
θ value	0.47712 (rank : 139)	NC score	0.026874 (rank : 283)
Query Neighborhood Hits	237	Target Neighborhood Hits	267	Shared Neighborhood Hits	8
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

NFM_HUMAN
θ value	0.47712 (rank : 140)	NC score	0.026070 (rank : 285)
Query Neighborhood Hits	237	Target Neighborhood Hits	1328	Shared Neighborhood Hits	50
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

FMN1B_MOUSE
θ value	0.62314 (rank : 141)	NC score	0.010767 (rank : 312)
Query Neighborhood Hits	237	Target Neighborhood Hits	447	Shared Neighborhood Hits	10
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

PKHA4_HUMAN
θ value	0.62314 (rank : 142)	NC score	0.161212 (rank : 118)
Query Neighborhood Hits	237	Target Neighborhood Hits	283	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	0.62314 (rank : 143)	NC score	0.166600 (rank : 117)
Query Neighborhood Hits	237	Target Neighborhood Hits	202	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RASA3_MOUSE
θ value	0.62314 (rank : 144)	NC score	0.031392 (rank : 278)
Query Neighborhood Hits	237	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

REEP2_MOUSE
θ value	0.62314 (rank : 145)	NC score	0.016692 (rank : 297)
Query Neighborhood Hits	237	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCD6	Gene names	Reep2
Domain Architecture	No domain graphic available
Description	Receptor expression-enhancing protein 2.

CEND1_MOUSE
θ value	0.813845 (rank : 146)	NC score	0.053073 (rank : 243)
Query Neighborhood Hits	237	Target Neighborhood Hits	260	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

DMP1_MOUSE
θ value	0.813845 (rank : 147)	NC score	0.022099 (rank : 292)
Query Neighborhood Hits	237	Target Neighborhood Hits	498	Shared Neighborhood Hits	26
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

IQEC3_MOUSE
θ value	0.813845 (rank : 148)	NC score	0.051236 (rank : 250)
Query Neighborhood Hits	237	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

NALP5_MOUSE
θ value	0.813845 (rank : 149)	NC score	0.009225 (rank : 318)
Query Neighborhood Hits	237	Target Neighborhood Hits	560	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

PDE2A_MOUSE
θ value	0.813845 (rank : 150)	NC score	0.009638 (rank : 315)
Query Neighborhood Hits	237	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

SPTB2_MOUSE
θ value	0.813845 (rank : 151)	NC score	0.043449 (rank : 266)
Query Neighborhood Hits	237	Target Neighborhood Hits	770	Shared Neighborhood Hits	53
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

CYH3_HUMAN
θ value	1.06291 (rank : 152)	NC score	0.090245 (rank : 137)
Query Neighborhood Hits	237	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DDEF2_HUMAN
θ value	1.06291 (rank : 153)	NC score	0.055362 (rank : 225)
Query Neighborhood Hits	237	Target Neighborhood Hits	599	Shared Neighborhood Hits	50
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	1.06291 (rank : 154)	NC score	0.055599 (rank : 224)
Query Neighborhood Hits	237	Target Neighborhood Hits	625	Shared Neighborhood Hits	47
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

FACD2_HUMAN
θ value	1.06291 (rank : 155)	NC score	0.024824 (rank : 286)
Query Neighborhood Hits	237	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXW9, Q2LA86, Q69YP9, Q6PJN7, Q9BQ06, Q9H9T9	Gene names	FANCD2
Domain Architecture	No domain graphic available
Description	Fanconi anemia group D2 protein (Protein FACD2).

PARG_HUMAN
θ value	1.06291 (rank : 156)	NC score	0.020139 (rank : 293)
Query Neighborhood Hits	237	Target Neighborhood Hits	97	Shared Neighborhood Hits	10
SwissProt Accessions	Q86W56, Q6E4P6, Q6E4P7, Q7Z742, Q9Y4W7	Gene names	PARG
Domain Architecture	No domain graphic available
Description	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143).

PSD4_HUMAN
θ value	1.06291 (rank : 157)	NC score	0.047744 (rank : 260)
Query Neighborhood Hits	237	Target Neighborhood Hits	178	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

SNX16_MOUSE
θ value	1.06291 (rank : 158)	NC score	0.015550 (rank : 298)
Query Neighborhood Hits	237	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C080	Gene names	Snx16
Domain Architecture	No domain graphic available
Description	Sorting nexin-16.

ZFY27_HUMAN
θ value	1.06291 (rank : 159)	NC score	0.225140 (rank : 105)
Query Neighborhood Hits	237	Target Neighborhood Hits	64	Shared Neighborhood Hits	40
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

GIT2_HUMAN
θ value	1.38821 (rank : 160)	NC score	0.017653 (rank : 295)
Query Neighborhood Hits	237	Target Neighborhood Hits	381	Shared Neighborhood Hits	20
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

KMHN1_HUMAN
θ value	1.38821 (rank : 161)	NC score	0.045945 (rank : 263)
Query Neighborhood Hits	237	Target Neighborhood Hits	950	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

MKNK1_MOUSE
θ value	1.38821 (rank : 162)	NC score	0.002440 (rank : 342)
Query Neighborhood Hits	237	Target Neighborhood Hits	811	Shared Neighborhood Hits	9
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

OSB11_MOUSE
θ value	1.38821 (rank : 163)	NC score	0.044821 (rank : 264)
Query Neighborhood Hits	237	Target Neighborhood Hits	71	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

PHLB2_MOUSE
θ value	1.38821 (rank : 164)	NC score	0.052492 (rank : 247)
Query Neighborhood Hits	237	Target Neighborhood Hits	1016	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

TAF3_MOUSE
θ value	1.38821 (rank : 165)	NC score	0.022784 (rank : 288)
Query Neighborhood Hits	237	Target Neighborhood Hits	463	Shared Neighborhood Hits	17
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

ZFY27_MOUSE
θ value	1.38821 (rank : 166)	NC score	0.230571 (rank : 103)
Query Neighborhood Hits	237	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

BRD7_HUMAN
θ value	1.81305 (rank : 167)	NC score	0.009374 (rank : 317)
Query Neighborhood Hits	237	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPI1, Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9UH59	Gene names	BRD7, BP75, CELTIX1
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1).

CSPG2_MOUSE
θ value	1.81305 (rank : 168)	NC score	0.000031 (rank : 345)
Query Neighborhood Hits	237	Target Neighborhood Hits	711	Shared Neighborhood Hits	8
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

HIC2_MOUSE
θ value	1.81305 (rank : 169)	NC score	-0.006856 (rank : 347)
Query Neighborhood Hits	237	Target Neighborhood Hits	821	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLZ6, Q3U030, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5	Gene names	Hic2, Kiaa1020
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2).

HRX_HUMAN
θ value	1.81305 (rank : 170)	NC score	0.012265 (rank : 308)
Query Neighborhood Hits	237	Target Neighborhood Hits	825	Shared Neighborhood Hits	25
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

K1914_HUMAN
θ value	1.81305 (rank : 171)	NC score	0.049163 (rank : 259)
Query Neighborhood Hits	237	Target Neighborhood Hits	255	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

PKHA2_MOUSE
θ value	1.81305 (rank : 172)	NC score	0.095474 (rank : 133)
Query Neighborhood Hits	237	Target Neighborhood Hits	116	Shared Neighborhood Hits	46
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PPIG_HUMAN
θ value	1.81305 (rank : 173)	NC score	0.008255 (rank : 321)
Query Neighborhood Hits	237	Target Neighborhood Hits	670	Shared Neighborhood Hits	22
SwissProt Accessions	Q13427, O00706, Q96DG9	Gene names	PPIG
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase G (EC 5.2.1.8) (Peptidyl-prolyl isomerase G) (PPIase G) (Rotamase G) (Cyclophilin G) (Clk-associating RS-cyclophilin) (CARS-cyclophilin) (CARS-Cyp) (SR-cyclophilin) (SRcyp) (SR-cyp) (CASP10).

RHG25_HUMAN
θ value	1.81305 (rank : 174)	NC score	0.068837 (rank : 174)
Query Neighborhood Hits	237	Target Neighborhood Hits	550	Shared Neighborhood Hits	67
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

2AAB_HUMAN
θ value	2.36792 (rank : 175)	NC score	0.014847 (rank : 300)
Query Neighborhood Hits	237	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

C43BP_HUMAN
θ value	2.36792 (rank : 176)	NC score	0.087142 (rank : 144)
Query Neighborhood Hits	237	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	2.36792 (rank : 177)	NC score	0.088395 (rank : 142)
Query Neighborhood Hits	237	Target Neighborhood Hits	91	Shared Neighborhood Hits	36
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

ITAX_HUMAN
θ value	2.36792 (rank : 178)	NC score	0.002685 (rank : 341)
Query Neighborhood Hits	237	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P20702, Q8IVA6	Gene names	ITGAX, CD11C
Domain Architecture
Description	Integrin alpha-X precursor (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (Leu M5) (CD11c antigen).

RPTOR_MOUSE
θ value	2.36792 (rank : 179)	NC score	0.009996 (rank : 314)
Query Neighborhood Hits	237	Target Neighborhood Hits	129	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

TGM2_MOUSE
θ value	2.36792 (rank : 180)	NC score	0.005282 (rank : 331)
Query Neighborhood Hits	237	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P21981, O88901, Q9R1F7	Gene names	Tgm2
Domain Architecture
Description	Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (TGase C) (TGC) (TG(C)) (Transglutaminase-2).

ASXL1_HUMAN
θ value	3.0926 (rank : 181)	NC score	0.012439 (rank : 306)
Query Neighborhood Hits	237	Target Neighborhood Hits	260	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

CEP35_HUMAN
θ value	3.0926 (rank : 182)	NC score	0.032793 (rank : 275)
Query Neighborhood Hits	237	Target Neighborhood Hits	811	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CIR_MOUSE
θ value	3.0926 (rank : 183)	NC score	0.017312 (rank : 296)
Query Neighborhood Hits	237	Target Neighborhood Hits	255	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

HUWE1_HUMAN
θ value	3.0926 (rank : 184)	NC score	0.010516 (rank : 313)
Query Neighborhood Hits	237	Target Neighborhood Hits	443	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

MAGD1_MOUSE
θ value	3.0926 (rank : 185)	NC score	0.003912 (rank : 337)
Query Neighborhood Hits	237	Target Neighborhood Hits	136	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

RASA3_HUMAN
θ value	3.0926 (rank : 186)	NC score	0.031422 (rank : 277)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	33
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

TITIN_HUMAN
θ value	3.0926 (rank : 187)	NC score	0.005185 (rank : 333)
Query Neighborhood Hits	237	Target Neighborhood Hits	2923	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

3BP2_MOUSE
θ value	4.03905 (rank : 188)	NC score	0.077773 (rank : 157)
Query Neighborhood Hits	237	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CHD9_HUMAN
θ value	4.03905 (rank : 189)	NC score	0.005146 (rank : 334)
Query Neighborhood Hits	237	Target Neighborhood Hits	343	Shared Neighborhood Hits	19
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

CKAP5_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.012286 (rank : 307)
Query Neighborhood Hits	237	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	Q14008, Q14668	Gene names	CKAP5, KIAA0097
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor over- expressed protein) (Ch-TOG protein).

CLSPN_HUMAN
θ value	4.03905 (rank : 191)	NC score	0.018941 (rank : 294)
Query Neighborhood Hits	237	Target Neighborhood Hits	433	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

CYH1_HUMAN
θ value	4.03905 (rank : 192)	NC score	0.086903 (rank : 145)
Query Neighborhood Hits	237	Target Neighborhood Hits	184	Shared Neighborhood Hits	62
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	4.03905 (rank : 193)	NC score	0.084047 (rank : 146)
Query Neighborhood Hits	237	Target Neighborhood Hits	176	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

KCD13_MOUSE
θ value	4.03905 (rank : 194)	NC score	0.005512 (rank : 330)
Query Neighborhood Hits	237	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGV7, Q6AXE9	Gene names	Kctd13, Poldip1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD13 (Polymerase delta-interacting protein 1).

LNX1_MOUSE
θ value	4.03905 (rank : 195)	NC score	0.005669 (rank : 328)
Query Neighborhood Hits	237	Target Neighborhood Hits	377	Shared Neighborhood Hits	8
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

NUMA1_HUMAN
θ value	4.03905 (rank : 196)	NC score	0.046138 (rank : 262)
Query Neighborhood Hits	237	Target Neighborhood Hits	1523	Shared Neighborhood Hits	57
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RBM19_HUMAN
θ value	4.03905 (rank : 197)	NC score	0.001440 (rank : 343)
Query Neighborhood Hits	237	Target Neighborhood Hits	331	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4C8, Q9BPY6, Q9UFN5	Gene names	RBM19, KIAA0682
Domain Architecture
Description	Probable RNA-binding protein 19 (RNA-binding motif protein 19).

RHG25_MOUSE
θ value	4.03905 (rank : 198)	NC score	0.067229 (rank : 176)
Query Neighborhood Hits	237	Target Neighborhood Hits	492	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

UACA_HUMAN
θ value	4.03905 (rank : 199)	NC score	0.030745 (rank : 279)
Query Neighborhood Hits	237	Target Neighborhood Hits	1622	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

ZBED1_HUMAN
θ value	4.03905 (rank : 200)	NC score	0.014252 (rank : 302)
Query Neighborhood Hits	237	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	O96006, Q96BY4	Gene names	ZBED1, ALTE, DREF, KIAA0785, TRAMP
Domain Architecture
Description	Zinc finger BED domain-containing protein 1 (dREF homolog) (Putative Ac-like transposable element).

3BP2_HUMAN
θ value	5.27518 (rank : 201)	NC score	0.080275 (rank : 152)
Query Neighborhood Hits	237	Target Neighborhood Hits	296	Shared Neighborhood Hits	37
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANLN_HUMAN
θ value	5.27518 (rank : 202)	NC score	0.026247 (rank : 284)
Query Neighborhood Hits	237	Target Neighborhood Hits	222	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CEND2_HUMAN
θ value	5.27518 (rank : 203)	NC score	0.047040 (rank : 261)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CYH2_HUMAN
θ value	5.27518 (rank : 204)	NC score	0.080991 (rank : 150)
Query Neighborhood Hits	237	Target Neighborhood Hits	175	Shared Neighborhood Hits	58
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	5.27518 (rank : 205)	NC score	0.080965 (rank : 151)
Query Neighborhood Hits	237	Target Neighborhood Hits	171	Shared Neighborhood Hits	58
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

E2F2_MOUSE
θ value	5.27518 (rank : 206)	NC score	0.005216 (rank : 332)
Query Neighborhood Hits	237	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P56931, Q8BID0	Gene names	E2f2
Domain Architecture	No domain graphic available
Description	Transcription factor E2F2 (E2F-2).

HS105_MOUSE
θ value	5.27518 (rank : 207)	NC score	0.006660 (rank : 327)
Query Neighborhood Hits	237	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	Q61699, Q3TNS2, Q3UIY8, Q62578, Q62579, Q6A0A5, Q8C430, Q8VCW6	Gene names	Hsph1, Hsp105, Hsp110, Kiaa0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock-related 100 kDa protein E7I) (HSP-E7I) (Heat shock 110 kDa protein) (42 degrees C-HSP).

LIPB1_HUMAN
θ value	5.27518 (rank : 208)	NC score	0.027133 (rank : 282)
Query Neighborhood Hits	237	Target Neighborhood Hits	640	Shared Neighborhood Hits	31
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

RC3H1_HUMAN
θ value	5.27518 (rank : 209)	NC score	0.013373 (rank : 304)
Query Neighborhood Hits	237	Target Neighborhood Hits	433	Shared Neighborhood Hits	15
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RC3H1_MOUSE
θ value	5.27518 (rank : 210)	NC score	0.015015 (rank : 299)
Query Neighborhood Hits	237	Target Neighborhood Hits	244	Shared Neighborhood Hits	12
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

SVIL_MOUSE
θ value	5.27518 (rank : 211)	NC score	0.008632 (rank : 320)
Query Neighborhood Hits	237	Target Neighborhood Hits	439	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

USP9X_HUMAN
θ value	5.27518 (rank : 212)	NC score	0.007360 (rank : 324)
Query Neighborhood Hits	237	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

USP9X_MOUSE
θ value	5.27518 (rank : 213)	NC score	0.007376 (rank : 323)
Query Neighborhood Hits	237	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

ATBF1_MOUSE
θ value	6.88961 (rank : 214)	NC score	0.002787 (rank : 340)
Query Neighborhood Hits	237	Target Neighborhood Hits	1841	Shared Neighborhood Hits	33
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CDON_MOUSE
θ value	6.88961 (rank : 215)	NC score	0.005629 (rank : 329)
Query Neighborhood Hits	237	Target Neighborhood Hits	410	Shared Neighborhood Hits	6
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

EDAR_HUMAN
θ value	6.88961 (rank : 216)	NC score	0.007270 (rank : 325)
Query Neighborhood Hits	237	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

LNX1_HUMAN
θ value	6.88961 (rank : 217)	NC score	0.004673 (rank : 336)
Query Neighborhood Hits	237	Target Neighborhood Hits	379	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LRTM4_HUMAN
θ value	6.88961 (rank : 218)	NC score	-0.002930 (rank : 346)
Query Neighborhood Hits	237	Target Neighborhood Hits	279	Shared Neighborhood Hits	2
SwissProt Accessions	Q86VH4	Gene names	LRRTM4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

RHG05_MOUSE
θ value	6.88961 (rank : 219)	NC score	0.022718 (rank : 289)
Query Neighborhood Hits	237	Target Neighborhood Hits	165	Shared Neighborhood Hits	10
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

SMAL1_HUMAN
θ value	6.88961 (rank : 220)	NC score	0.003672 (rank : 338)
Query Neighborhood Hits	237	Target Neighborhood Hits	174	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

SYTL2_MOUSE
θ value	6.88961 (rank : 221)	NC score	0.011726 (rank : 309)
Query Neighborhood Hits	237	Target Neighborhood Hits	253	Shared Neighborhood Hits	16
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

TACC2_HUMAN
θ value	6.88961 (rank : 222)	NC score	0.033584 (rank : 274)
Query Neighborhood Hits	237	Target Neighborhood Hits	856	Shared Neighborhood Hits	31
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

ZN318_HUMAN
θ value	6.88961 (rank : 223)	NC score	0.031622 (rank : 276)
Query Neighborhood Hits	237	Target Neighborhood Hits	497	Shared Neighborhood Hits	24
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

AKT1_HUMAN
θ value	8.99809 (rank : 224)	NC score	0.001319 (rank : 344)
Query Neighborhood Hits	237	Target Neighborhood Hits	885	Shared Neighborhood Hits	32
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

CENA2_HUMAN
θ value	8.99809 (rank : 225)	NC score	0.022268 (rank : 291)
Query Neighborhood Hits	237	Target Neighborhood Hits	83	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

DDFL1_MOUSE
θ value	8.99809 (rank : 226)	NC score	0.028464 (rank : 281)
Query Neighborhood Hits	237	Target Neighborhood Hits	324	Shared Neighborhood Hits	24
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

HIC2_HUMAN
θ value	8.99809 (rank : 227)	NC score	-0.007966 (rank : 348)
Query Neighborhood Hits	237	Target Neighborhood Hits	820	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JB3, Q96KR3, Q9NSM9, Q9UPX9	Gene names	HIC2, HRG22, KIAA1020, ZBTB30
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2) (Hic-3) (HIC1-related gene on chromosome 22) (Zinc finger and BTB domain-containing protein 30).

MCM4_HUMAN
θ value	8.99809 (rank : 228)	NC score	0.011540 (rank : 310)
Query Neighborhood Hits	237	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

OSBP1_HUMAN
θ value	8.99809 (rank : 229)	NC score	0.041321 (rank : 267)
Query Neighborhood Hits	237	Target Neighborhood Hits	180	Shared Neighborhood Hits	47
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

RIF1_HUMAN
θ value	8.99809 (rank : 230)	NC score	0.011287 (rank : 311)
Query Neighborhood Hits	237	Target Neighborhood Hits	320	Shared Neighborhood Hits	16
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

SEC63_MOUSE
θ value	8.99809 (rank : 231)	NC score	0.007658 (rank : 322)
Query Neighborhood Hits	237	Target Neighborhood Hits	601	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SPTA1_HUMAN
θ value	8.99809 (rank : 232)	NC score	0.056829 (rank : 214)
Query Neighborhood Hits	237	Target Neighborhood Hits	748	Shared Neighborhood Hits	50
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

STAP1_HUMAN
θ value	8.99809 (rank : 233)	NC score	0.013975 (rank : 303)
Query Neighborhood Hits	237	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULZ2	Gene names	STAP1, BRDG1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1) (BCR downstream signaling protein 1) (Docking protein BRDG1).

TBCD8_MOUSE
θ value	8.99809 (rank : 234)	NC score	0.003648 (rank : 339)
Query Neighborhood Hits	237	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z1A9	Gene names	Tbc1d8, Hblp1, Vrp
Domain Architecture
Description	TBC1 domain family member 8 (Vascular Rab-GAP/TBC-containing protein) (BUB2-like protein 1).

TMF1_HUMAN
θ value	8.99809 (rank : 235)	NC score	0.036177 (rank : 270)
Query Neighborhood Hits	237	Target Neighborhood Hits	987	Shared Neighborhood Hits	40
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

YIPF1_HUMAN
θ value	8.99809 (rank : 236)	NC score	0.004864 (rank : 335)
Query Neighborhood Hits	237	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y548, Q9NWJ1	Gene names	YIPF1
Domain Architecture	No domain graphic available
Description	Protein YIPF1 (YIP1 family member 1).

ZCH10_MOUSE
θ value	8.99809 (rank : 237)	NC score	0.008990 (rank : 319)
Query Neighborhood Hits	237	Target Neighborhood Hits	133	Shared Neighborhood Hits	7
SwissProt Accessions	Q9CX48	Gene names	Zcchc10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

41_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.063186 (rank : 181)
Query Neighborhood Hits	237	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.061409 (rank : 188)
Query Neighborhood Hits	237	Target Neighborhood Hits	184	Shared Neighborhood Hits	9
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ABI1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.053093 (rank : 242)
Query Neighborhood Hits	237	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.054310 (rank : 234)
Query Neighborhood Hits	237	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.054540 (rank : 232)
Query Neighborhood Hits	237	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

AHI1_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.053928 (rank : 237)
Query Neighborhood Hits	237	Target Neighborhood Hits	537	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG2_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.379395 (rank : 70)
Query Neighborhood Hits	237	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG3_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.411584 (rank : 60)
Query Neighborhood Hits	237	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.412036 (rank : 59)
Query Neighborhood Hits	237	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG6_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.294739 (rank : 96)
Query Neighborhood Hits	237	Target Neighborhood Hits	376	Shared Neighborhood Hits	62
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.274181 (rank : 99)
Query Neighborhood Hits	237	Target Neighborhood Hits	394	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.354663 (rank : 81)
Query Neighborhood Hits	237	Target Neighborhood Hits	347	Shared Neighborhood Hits	72
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.331956 (rank : 87)
Query Neighborhood Hits	237	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

BI2L1_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.059079 (rank : 202)
Query Neighborhood Hits	237	Target Neighborhood Hits	156	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CD2AP_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.082395 (rank : 147)
Query Neighborhood Hits	237	Target Neighborhood Hits	315	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.082324 (rank : 148)
Query Neighborhood Hits	237	Target Neighborhood Hits	336	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CEND1_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.055855 (rank : 220)
Query Neighborhood Hits	237	Target Neighborhood Hits	284	Shared Neighborhood Hits	58
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CJ064_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.060722 (rank : 195)
Query Neighborhood Hits	237	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

CRKL_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.054403 (rank : 233)
Query Neighborhood Hits	237	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.052653 (rank : 245)
Query Neighborhood Hits	237	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.050236 (rank : 256)
Query Neighborhood Hits	237	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DGKH_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.060566 (rank : 196)
Query Neighborhood Hits	237	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

E41L1_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.060997 (rank : 191)
Query Neighborhood Hits	237	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.060190 (rank : 199)
Query Neighborhood Hits	237	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.059676 (rank : 201)
Query Neighborhood Hits	237	Target Neighborhood Hits	287	Shared Neighborhood Hits	8
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.061880 (rank : 186)
Query Neighborhood Hits	237	Target Neighborhood Hits	459	Shared Neighborhood Hits	21
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.063473 (rank : 179)
Query Neighborhood Hits	237	Target Neighborhood Hits	113	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.061996 (rank : 185)
Query Neighborhood Hits	237	Target Neighborhood Hits	250	Shared Neighborhood Hits	11
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.062756 (rank : 182)
Query Neighborhood Hits	237	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LA_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.056949 (rank : 212)
Query Neighborhood Hits	237	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.056311 (rank : 218)
Query Neighborhood Hits	237	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LB_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.063313 (rank : 180)
Query Neighborhood Hits	237	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.062725 (rank : 183)
Query Neighborhood Hits	237	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EP15R_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.056830 (rank : 213)
Query Neighborhood Hits	237	Target Neighborhood Hits	1083	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.057040 (rank : 211)
Query Neighborhood Hits	237	Target Neighborhood Hits	1135	Shared Neighborhood Hits	47
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.056402 (rank : 216)
Query Neighborhood Hits	237	Target Neighborhood Hits	1021	Shared Neighborhood Hits	43
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.053200 (rank : 241)
Query Neighborhood Hits	237	Target Neighborhood Hits	820	Shared Neighborhood Hits	33
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EZRI_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.054051 (rank : 236)
Query Neighborhood Hits	237	Target Neighborhood Hits	663	Shared Neighborhood Hits	30
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.053555 (rank : 239)
Query Neighborhood Hits	237	Target Neighborhood Hits	693	Shared Neighborhood Hits	31
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FNBP2_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.051019 (rank : 252)
Query Neighborhood Hits	237	Target Neighborhood Hits	432	Shared Neighborhood Hits	33
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FRMD5_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.060893 (rank : 193)
Query Neighborhood Hits	237	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.061301 (rank : 189)
Query Neighborhood Hits	237	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

GRAP2_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.056325 (rank : 217)
Query Neighborhood Hits	237	Target Neighborhood Hits	304	Shared Neighborhood Hits	21
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.055691 (rank : 223)
Query Neighborhood Hits	237	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.070486 (rank : 168)
Query Neighborhood Hits	237	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.068915 (rank : 173)
Query Neighborhood Hits	237	Target Neighborhood Hits	309	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.060944 (rank : 192)
Query Neighborhood Hits	237	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.060876 (rank : 194)
Query Neighborhood Hits	237	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.055116 (rank : 227)
Query Neighborhood Hits	237	Target Neighborhood Hits	358	Shared Neighborhood Hits	25
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.055730 (rank : 222)
Query Neighborhood Hits	237	Target Neighborhood Hits	329	Shared Neighborhood Hits	23
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

MERL_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.054171 (rank : 235)
Query Neighborhood Hits	237	Target Neighborhood Hits	532	Shared Neighborhood Hits	23
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.054563 (rank : 231)
Query Neighborhood Hits	237	Target Neighborhood Hits	524	Shared Neighborhood Hits	23
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MOES_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.057285 (rank : 210)
Query Neighborhood Hits	237	Target Neighborhood Hits	892	Shared Neighborhood Hits	38
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.058039 (rank : 207)
Query Neighborhood Hits	237	Target Neighborhood Hits	923	Shared Neighborhood Hits	39
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYLIP_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.052599 (rank : 246)
Query Neighborhood Hits	237	Target Neighborhood Hits	162	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.052951 (rank : 244)
Query Neighborhood Hits	237	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NCF1_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.093816 (rank : 136)
Query Neighborhood Hits	237	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.088575 (rank : 141)
Query Neighborhood Hits	237	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.079086 (rank : 154)
Query Neighborhood Hits	237	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.067393 (rank : 175)
Query Neighborhood Hits	237	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.066319 (rank : 177)
Query Neighborhood Hits	237	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.072690 (rank : 165)
Query Neighborhood Hits	237	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.069947 (rank : 169)
Query Neighborhood Hits	237	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.050934 (rank : 253)
Query Neighborhood Hits	237	Target Neighborhood Hits	457	Shared Neighborhood Hits	33
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PKHA1_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.062335 (rank : 184)
Query Neighborhood Hits	237	Target Neighborhood Hits	127	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.061149 (rank : 190)
Query Neighborhood Hits	237	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.080025 (rank : 153)
Query Neighborhood Hits	237	Target Neighborhood Hits	119	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLCG1_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.050758 (rank : 254)
Query Neighborhood Hits	237	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLEK_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.094945 (rank : 134)
Query Neighborhood Hits	237	Target Neighborhood Hits	110	Shared Neighborhood Hits	50
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.088714 (rank : 140)
Query Neighborhood Hits	237	Target Neighborhood Hits	109	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PPIP1_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.055806 (rank : 221)
Query Neighborhood Hits	237	Target Neighborhood Hits	389	Shared Neighborhood Hits	29
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.054909 (rank : 228)
Query Neighborhood Hits	237	Target Neighborhood Hits	377	Shared Neighborhood Hits	30
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RADI_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.057506 (rank : 209)
Query Neighborhood Hits	237	Target Neighborhood Hits	741	Shared Neighborhood Hits	33
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.056629 (rank : 215)
Query Neighborhood Hits	237	Target Neighborhood Hits	773	Shared Neighborhood Hits	32
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

REPS1_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.056250 (rank : 219)
Query Neighborhood Hits	237	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RFFL_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.058780 (rank : 203)
Query Neighborhood Hits	237	Target Neighborhood Hits	175	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.069922 (rank : 170)
Query Neighborhood Hits	237	Target Neighborhood Hits	145	Shared Neighborhood Hits	32
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RHG04_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.053806 (rank : 238)
Query Neighborhood Hits	237	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RNF34_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.064075 (rank : 178)
Query Neighborhood Hits	237	Target Neighborhood Hits	153	Shared Neighborhood Hits	31
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.069265 (rank : 172)
Query Neighborhood Hits	237	Target Neighborhood Hits	160	Shared Neighborhood Hits	34
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RUFY3_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.094881 (rank : 135)
Query Neighborhood Hits	237	Target Neighborhood Hits	594	Shared Neighborhood Hits	24
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.095683 (rank : 132)
Query Neighborhood Hits	237	Target Neighborhood Hits	579	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SH3G1_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.051481 (rank : 249)
Query Neighborhood Hits	237	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.052065 (rank : 248)
Query Neighborhood Hits	237	Target Neighborhood Hits	324	Shared Neighborhood Hits	28
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.050067 (rank : 257)
Query Neighborhood Hits	237	Target Neighborhood Hits	319	Shared Neighborhood Hits	26
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.050391 (rank : 255)
Query Neighborhood Hits	237	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.051195 (rank : 251)
Query Neighborhood Hits	237	Target Neighborhood Hits	236	Shared Neighborhood Hits	21
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.089171 (rank : 138)
Query Neighborhood Hits	237	Target Neighborhood Hits	341	Shared Neighborhood Hits	28
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.081187 (rank : 149)
Query Neighborhood Hits	237	Target Neighborhood Hits	332	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SOS1_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.207416 (rank : 109)
Query Neighborhood Hits	237	Target Neighborhood Hits	274	Shared Neighborhood Hits	43
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.191952 (rank : 114)
Query Neighborhood Hits	237	Target Neighborhood Hits	281	Shared Neighborhood Hits	41
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.201262 (rank : 111)
Query Neighborhood Hits	237	Target Neighborhood Hits	193	Shared Neighborhood Hits	42
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SPTA1_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.055185 (rank : 226)
Query Neighborhood Hits	237	Target Neighborhood Hits	675	Shared Neighborhood Hits	46
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.060482 (rank : 197)
Query Neighborhood Hits	237	Target Neighborhood Hits	888	Shared Neighborhood Hits	49
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.075199 (rank : 160)
Query Neighborhood Hits	237	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.077846 (rank : 156)
Query Neighborhood Hits	237	Target Neighborhood Hits	409	Shared Neighborhood Hits	27
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.054747 (rank : 230)
Query Neighborhood Hits	237	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.053258 (rank : 240)
Query Neighborhood Hits	237	Target Neighborhood Hits	292	Shared Neighborhood Hits	22
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.050003 (rank : 258)
Query Neighborhood Hits	237	Target Neighborhood Hits	390	Shared Neighborhood Hits	31
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAC3_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.057787 (rank : 208)
Query Neighborhood Hits	237	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.058415 (rank : 206)
Query Neighborhood Hits	237	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.061727 (rank : 187)
Query Neighborhood Hits	237	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.060163 (rank : 200)
Query Neighborhood Hits	237	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.073312 (rank : 162)
Query Neighborhood Hits	237	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.073033 (rank : 163)
Query Neighborhood Hits	237	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.069894 (rank : 171)
Query Neighborhood Hits	237	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.070540 (rank : 167)
Query Neighborhood Hits	237	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.054871 (rank : 229)
Query Neighborhood Hits	237	Target Neighborhood Hits	872	Shared Neighborhood Hits	38
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.058749 (rank : 204)
Query Neighborhood Hits	237	Target Neighborhood Hits	409	Shared Neighborhood Hits	35
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.072718 (rank : 164)
Query Neighborhood Hits	237	Target Neighborhood Hits	270	Shared Neighborhood Hits	25
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.071914 (rank : 166)
Query Neighborhood Hits	237	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

FGD6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	237	Target Neighborhood Hits	237	Shared Neighborhood Hits	237
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
NC score	0.984160 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	237	Target Neighborhood Hits	282	Shared Neighborhood Hits	162
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD5_HUMAN
NC score	0.906746 (rank : 3)	θ value	9.24197e-138 (rank : 3)
Query Neighborhood Hits	237	Target Neighborhood Hits	235	Shared Neighborhood Hits	116
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD2_MOUSE
NC score	0.905840 (rank : 4)	θ value	9.41505e-74 (rank : 10)
Query Neighborhood Hits	237	Target Neighborhood Hits	163	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.903855 (rank : 5)	θ value	1.11217e-74 (rank : 8)
Query Neighborhood Hits	237	Target Neighborhood Hits	151	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD5_MOUSE
NC score	0.902333 (rank : 6)	θ value	2.52267e-127 (rank : 4)
Query Neighborhood Hits	237	Target Neighborhood Hits	170	Shared Neighborhood Hits	112
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD4_HUMAN
NC score	0.899175 (rank : 7)	θ value	2.73302e-81 (rank : 6)
Query Neighborhood Hits	237	Target Neighborhood Hits	219	Shared Neighborhood Hits	129
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.896103 (rank : 8)	θ value	1.2268e-81 (rank : 5)
Query Neighborhood Hits	237	Target Neighborhood Hits	227	Shared Neighborhood Hits	128
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
NC score	0.884692 (rank : 9)	θ value	4.22625e-74 (rank : 9)
Query Neighborhood Hits	237	Target Neighborhood Hits	367	Shared Neighborhood Hits	118
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.882612 (rank : 10)	θ value	8.51556e-75 (rank : 7)
Query Neighborhood Hits	237	Target Neighborhood Hits	387	Shared Neighborhood Hits	116
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
NC score	0.868451 (rank : 11)	θ value	1.08223e-53 (rank : 11)
Query Neighborhood Hits	237	Target Neighborhood Hits	249	Shared Neighborhood Hits	107
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
NC score	0.860615 (rank : 12)	θ value	3.48141e-52 (rank : 12)
Query Neighborhood Hits	237	Target Neighborhood Hits	257	Shared Neighborhood Hits	117
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PKHF2_HUMAN
NC score	0.733771 (rank : 13)	θ value	3.50572e-28 (rank : 18)
Query Neighborhood Hits	237	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.733211 (rank : 14)	θ value	4.57862e-28 (rank : 19)
Query Neighborhood Hits	237	Target Neighborhood Hits	77	Shared Neighborhood Hits	64
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_HUMAN
NC score	0.733015 (rank : 15)	θ value	1.08979e-29 (rank : 16)
Query Neighborhood Hits	237	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.731069 (rank : 16)	θ value	4.14116e-29 (rank : 17)
Query Neighborhood Hits	237	Target Neighborhood Hits	80	Shared Neighborhood Hits	58
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ECT2_MOUSE
NC score	0.646946 (rank : 17)	θ value	3.88503e-19 (rank : 20)
Query Neighborhood Hits	237	Target Neighborhood Hits	98	Shared Neighborhood Hits	66
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.633325 (rank : 18)	θ value	1.47631e-18 (rank : 22)
Query Neighborhood Hits	237	Target Neighborhood Hits	98	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.630271 (rank : 19)	θ value	1.63225e-17 (rank : 24)
Query Neighborhood Hits	237	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PKHG1_HUMAN
NC score	0.599835 (rank : 20)	θ value	3.63628e-17 (rank : 26)
Query Neighborhood Hits	237	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ZFY28_HUMAN
NC score	0.572850 (rank : 21)	θ value	9.26847e-13 (rank : 34)
Query Neighborhood Hits	237	Target Neighborhood Hits	152	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ARHGA_HUMAN
NC score	0.569054 (rank : 22)	θ value	3.07829e-16 (rank : 28)
Query Neighborhood Hits	237	Target Neighborhood Hits	187	Shared Neighborhood Hits	66
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG5_HUMAN
NC score	0.567467 (rank : 23)	θ value	1.133e-10 (rank : 48)
Query Neighborhood Hits	237	Target Neighborhood Hits	172	Shared Neighborhood Hits	68
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGA_MOUSE
NC score	0.566680 (rank : 24)	θ value	4.02038e-16 (rank : 29)
Query Neighborhood Hits	237	Target Neighborhood Hits	125	Shared Neighborhood Hits	60
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ZFYV9_HUMAN
NC score	0.564634 (rank : 25)	θ value	4.02038e-16 (rank : 30)
Query Neighborhood Hits	237	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY21_MOUSE
NC score	0.561424 (rank : 26)	θ value	5.62301e-10 (rank : 55)
Query Neighborhood Hits	237	Target Neighborhood Hits	72	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_HUMAN
NC score	0.556809 (rank : 27)	θ value	4.30538e-10 (rank : 54)
Query Neighborhood Hits	237	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_MOUSE
NC score	0.553287 (rank : 28)	θ value	1.63225e-17 (rank : 25)
Query Neighborhood Hits	237	Target Neighborhood Hits	108	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

FARP2_MOUSE
NC score	0.553023 (rank : 29)	θ value	9.50281e-42 (rank : 13)
Query Neighborhood Hits	237	Target Neighborhood Hits	209	Shared Neighborhood Hits	99
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGG_HUMAN
NC score	0.548788 (rank : 30)	θ value	6.87365e-08 (rank : 68)
Query Neighborhood Hits	237	Target Neighborhood Hits	129	Shared Neighborhood Hits	64
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_HUMAN
NC score	0.548332 (rank : 31)	θ value	1.133e-10 (rank : 49)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ZFY16_HUMAN
NC score	0.545512 (rank : 32)	θ value	1.38178e-16 (rank : 27)
Query Neighborhood Hits	237	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

FARP2_HUMAN
NC score	0.542723 (rank : 33)	θ value	6.15952e-41 (rank : 14)
Query Neighborhood Hits	237	Target Neighborhood Hits	240	Shared Neighborhood Hits	95
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG4_MOUSE
NC score	0.538763 (rank : 34)	θ value	1.47974e-10 (rank : 50)
Query Neighborhood Hits	237	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NGEF_MOUSE
NC score	0.536746 (rank : 35)	θ value	8.67504e-11 (rank : 47)
Query Neighborhood Hits	237	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_MOUSE
NC score	0.535029 (rank : 36)	θ value	1.80886e-08 (rank : 65)
Query Neighborhood Hits	237	Target Neighborhood Hits	152	Shared Neighborhood Hits	64
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG4_HUMAN
NC score	0.529683 (rank : 37)	θ value	3.52202e-12 (rank : 36)
Query Neighborhood Hits	237	Target Neighborhood Hits	242	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FARP1_HUMAN
NC score	0.517822 (rank : 38)	θ value	2.86122e-38 (rank : 15)
Query Neighborhood Hits	237	Target Neighborhood Hits	241	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG9_HUMAN
NC score	0.511693 (rank : 39)	θ value	6.21693e-09 (rank : 61)
Query Neighborhood Hits	237	Target Neighborhood Hits	235	Shared Neighborhood Hits	68
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.509466 (rank : 40)	θ value	3.08544e-08 (rank : 66)
Query Neighborhood Hits	237	Target Neighborhood Hits	234	Shared Neighborhood Hits	68
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGF_HUMAN
NC score	0.507111 (rank : 41)	θ value	1.99992e-07 (rank : 73)
Query Neighborhood Hits	237	Target Neighborhood Hits	214	Shared Neighborhood Hits	63
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

MCF2_HUMAN
NC score	0.504244 (rank : 42)	θ value	4.76016e-09 (rank : 59)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MCF2L_MOUSE
NC score	0.479864 (rank : 43)	θ value	6.87365e-08 (rank : 69)
Query Neighborhood Hits	237	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

TIAM1_HUMAN
NC score	0.469432 (rank : 44)	θ value	6.43352e-06 (rank : 85)
Query Neighborhood Hits	237	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.467731 (rank : 45)	θ value	7.1131e-05 (rank : 90)
Query Neighborhood Hits	237	Target Neighborhood Hits	205	Shared Neighborhood Hits	80
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

HAPIP_HUMAN
NC score	0.460344 (rank : 46)	θ value	1.25267e-09 (rank : 57)
Query Neighborhood Hits	237	Target Neighborhood Hits	350	Shared Neighborhood Hits	80
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG2_MOUSE
NC score	0.457170 (rank : 47)	θ value	1.09739e-05 (rank : 86)
Query Neighborhood Hits	237	Target Neighborhood Hits	120	Shared Neighborhood Hits	58
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG1_HUMAN
NC score	0.456526 (rank : 48)	θ value	3.41135e-07 (rank : 75)
Query Neighborhood Hits	237	Target Neighborhood Hits	176	Shared Neighborhood Hits	61
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

GNRP_MOUSE
NC score	0.455597 (rank : 49)	θ value	3.52202e-12 (rank : 37)
Query Neighborhood Hits	237	Target Neighborhood Hits	191	Shared Neighborhood Hits	86
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG8_HUMAN
NC score	0.454729 (rank : 50)	θ value	4.45536e-07 (rank : 76)
Query Neighborhood Hits	237	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG1_MOUSE
NC score	0.435148 (rank : 51)	θ value	1.69304e-06 (rank : 81)
Query Neighborhood Hits	237	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGB_HUMAN
NC score	0.434510 (rank : 52)	θ value	0.000121331 (rank : 94)
Query Neighborhood Hits	237	Target Neighborhood Hits	375	Shared Neighborhood Hits	68
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GNRP_HUMAN
NC score	0.427581 (rank : 53)	θ value	2.28291e-11 (rank : 42)
Query Neighborhood Hits	237	Target Neighborhood Hits	239	Shared Neighborhood Hits	88
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHG4_HUMAN
NC score	0.425930 (rank : 54)	θ value	3.19293e-05 (rank : 89)
Query Neighborhood Hits	237	Target Neighborhood Hits	200	Shared Neighborhood Hits	50
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ZFYV1_HUMAN
NC score	0.423141 (rank : 55)	θ value	5.81887e-07 (rank : 79)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

HGS_MOUSE
NC score	0.421969 (rank : 56)	θ value	1.38499e-08 (rank : 64)
Query Neighborhood Hits	237	Target Neighborhood Hits	589	Shared Neighborhood Hits	63
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.421962 (rank : 57)	θ value	4.0297e-08 (rank : 67)
Query Neighborhood Hits	237	Target Neighborhood Hits	517	Shared Neighborhood Hits	62
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ZFYV1_MOUSE
NC score	0.418184 (rank : 58)	θ value	2.21117e-06 (rank : 84)
Query Neighborhood Hits	237	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ARHG3_MOUSE
NC score	0.412036 (rank : 59)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	237	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.411584 (rank : 60)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	237	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

BCR_HUMAN
NC score	0.409511 (rank : 61)	θ value	1.16975e-15 (rank : 31)
Query Neighborhood Hits	237	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

LBC_HUMAN
NC score	0.404113 (rank : 62)	θ value	0.00665767 (rank : 113)
Query Neighborhood Hits	237	Target Neighborhood Hits	90	Shared Neighborhood Hits	52
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ABR_HUMAN
NC score	0.403801 (rank : 63)	θ value	2.0648e-12 (rank : 35)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHGC_HUMAN
NC score	0.403252 (rank : 64)	θ value	0.000158464 (rank : 95)
Query Neighborhood Hits	237	Target Neighborhood Hits	351	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.398449 (rank : 65)	θ value	0.000461057 (rank : 100)
Query Neighborhood Hits	237	Target Neighborhood Hits	344	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RBNS5_HUMAN
NC score	0.394525 (rank : 66)	θ value	9.29e-05 (rank : 92)
Query Neighborhood Hits	237	Target Neighborhood Hits	242	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.387781 (rank : 67)	θ value	9.29e-05 (rank : 93)
Query Neighborhood Hits	237	Target Neighborhood Hits	266	Shared Neighborhood Hits	55
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ARHG8_MOUSE
NC score	0.387132 (rank : 68)	θ value	1.99992e-07 (rank : 72)
Query Neighborhood Hits	237	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ZFY19_HUMAN
NC score	0.379755 (rank : 69)	θ value	1.69304e-06 (rank : 82)
Query Neighborhood Hits	237	Target Neighborhood Hits	206	Shared Neighborhood Hits	48
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ARHG2_HUMAN
NC score	0.379395 (rank : 70)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	237	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ITSN2_HUMAN
NC score	0.375465 (rank : 71)	θ value	1.52774e-15 (rank : 32)
Query Neighborhood Hits	237	Target Neighborhood Hits	1173	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV_MOUSE
NC score	0.374520 (rank : 72)	θ value	1.99992e-07 (rank : 74)
Query Neighborhood Hits	237	Target Neighborhood Hits	430	Shared Neighborhood Hits	69
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

FYV1_HUMAN
NC score	0.374256 (rank : 73)	θ value	8.97725e-08 (rank : 70)
Query Neighborhood Hits	237	Target Neighborhood Hits	217	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.370704 (rank : 74)	θ value	1.17247e-07 (rank : 71)
Query Neighborhood Hits	237	Target Neighborhood Hits	191	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

VAV_HUMAN
NC score	0.369208 (rank : 75)	θ value	2.21117e-06 (rank : 83)
Query Neighborhood Hits	237	Target Neighborhood Hits	452	Shared Neighborhood Hits	68
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ZFY19_MOUSE
NC score	0.363549 (rank : 76)	θ value	0.000158464 (rank : 96)
Query Neighborhood Hits	237	Target Neighborhood Hits	143	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ITSN2_MOUSE
NC score	0.360896 (rank : 77)	θ value	5.8054e-15 (rank : 33)
Query Neighborhood Hits	237	Target Neighborhood Hits	1371	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV2_MOUSE
NC score	0.360810 (rank : 78)	θ value	2.44474e-05 (rank : 88)
Query Neighborhood Hits	237	Target Neighborhood Hits	456	Shared Neighborhood Hits	73
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.358031 (rank : 79)	θ value	4.76016e-09 (rank : 60)
Query Neighborhood Hits	237	Target Neighborhood Hits	404	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.357255 (rank : 80)	θ value	1.63604e-09 (rank : 58)
Query Neighborhood Hits	237	Target Neighborhood Hits	398	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG7_HUMAN
NC score	0.354663 (rank : 81)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	237	Target Neighborhood Hits	347	Shared Neighborhood Hits	72
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DNMBP_MOUSE
NC score	0.354661 (rank : 82)	θ value	0.00665767 (rank : 112)
Query Neighborhood Hits	237	Target Neighborhood Hits	435	Shared Neighborhood Hits	69
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_HUMAN
NC score	0.351614 (rank : 83)	θ value	0.000270298 (rank : 99)
Query Neighborhood Hits	237	Target Neighborhood Hits	453	Shared Neighborhood Hits	72
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ITSN1_HUMAN
NC score	0.350201 (rank : 84)	θ value	1.13037e-18 (rank : 21)
Query Neighborhood Hits	237	Target Neighborhood Hits	1757	Shared Neighborhood Hits	103
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.349653 (rank : 85)	θ value	5.60996e-18 (rank : 23)
Query Neighborhood Hits	237	Target Neighborhood Hits	1669	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DNMBP_HUMAN
NC score	0.341357 (rank : 86)	θ value	0.00298849 (rank : 109)
Query Neighborhood Hits	237	Target Neighborhood Hits	413	Shared Neighborhood Hits	77
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG7_MOUSE
NC score	0.331956 (rank : 87)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	237	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

RGNEF_MOUSE
NC score	0.330728 (rank : 88)	θ value	0.00020696 (rank : 97)
Query Neighborhood Hits	237	Target Neighborhood Hits	641	Shared Neighborhood Hits	72
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RUFY2_MOUSE
NC score	0.322692 (rank : 89)	θ value	3.52202e-12 (rank : 38)
Query Neighborhood Hits	237	Target Neighborhood Hits	820	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.317997 (rank : 90)	θ value	1.9326e-10 (rank : 52)
Query Neighborhood Hits	237	Target Neighborhood Hits	765	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

WDFY3_MOUSE
NC score	0.316497 (rank : 91)	θ value	5.08577e-11 (rank : 45)
Query Neighborhood Hits	237	Target Neighborhood Hits	332	Shared Neighborhood Hits	52
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.316044 (rank : 92)	θ value	5.08577e-11 (rank : 44)
Query Neighborhood Hits	237	Target Neighborhood Hits	348	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

MTMR3_HUMAN
NC score	0.315922 (rank : 93)	θ value	1.9326e-10 (rank : 51)
Query Neighborhood Hits	237	Target Neighborhood Hits	163	Shared Neighborhood Hits	52
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY1_HUMAN
NC score	0.313794 (rank : 94)	θ value	3.89403e-11 (rank : 43)
Query Neighborhood Hits	237	Target Neighborhood Hits	848	Shared Neighborhood Hits	71
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY1_HUMAN
NC score	0.305434 (rank : 95)	θ value	0.00020696 (rank : 98)
Query Neighborhood Hits	237	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ARHG6_HUMAN
NC score	0.294739 (rank : 96)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	237	Target Neighborhood Hits	376	Shared Neighborhood Hits	62
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

WDFY2_MOUSE
NC score	0.283602 (rank : 97)	θ value	0.00102713 (rank : 103)
Query Neighborhood Hits	237	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.281404 (rank : 98)	θ value	0.00102713 (rank : 102)
Query Neighborhood Hits	237	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

ARHG6_MOUSE
NC score	0.274181 (rank : 99)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	237	Target Neighborhood Hits	394	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

RUFY2_HUMAN
NC score	0.264468 (rank : 100)	θ value	1.74796e-11 (rank : 41)
Query Neighborhood Hits	237	Target Neighborhood Hits	1208	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PKHA6_HUMAN
NC score	0.249239 (rank : 101)	θ value	7.59969e-07 (rank : 80)
Query Neighborhood Hits	237	Target Neighborhood Hits	556	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.246002 (rank : 102)	θ value	4.45536e-07 (rank : 77)
Query Neighborhood Hits	237	Target Neighborhood Hits	591	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ZFY27_MOUSE
NC score	0.230571 (rank : 103)	θ value	1.38821 (rank : 166)
Query Neighborhood Hits	237	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FYCO1_HUMAN
NC score	0.226423 (rank : 104)	θ value	1.25267e-09 (rank : 56)
Query Neighborhood Hits	237	Target Neighborhood Hits	1149	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ZFY27_HUMAN
NC score	0.225140 (rank : 105)	θ value	1.06291 (rank : 159)
Query Neighborhood Hits	237	Target Neighborhood Hits	64	Shared Neighborhood Hits	40
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ANFY1_MOUSE
NC score	0.209204 (rank : 106)	θ value	8.11959e-09 (rank : 62)
Query Neighborhood Hits	237	Target Neighborhood Hits	480	Shared Neighborhood Hits	59
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

FYCO1_MOUSE
NC score	0.208854 (rank : 107)	θ value	5.81887e-07 (rank : 78)
Query Neighborhood Hits	237	Target Neighborhood Hits	1059	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ANFY1_HUMAN
NC score	0.208742 (rank : 108)	θ value	1.06045e-08 (rank : 63)
Query Neighborhood Hits	237	Target Neighborhood Hits	480	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

SOS1_HUMAN
NC score	0.207416 (rank : 109)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	237	Target Neighborhood Hits	274	Shared Neighborhood Hits	43
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

EEA1_MOUSE
NC score	0.207067 (rank : 110)	θ value	2.52405e-10 (rank : 53)
Query Neighborhood Hits	237	Target Neighborhood Hits	1637	Shared Neighborhood Hits	92
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SOS2_HUMAN
NC score	0.201262 (rank : 111)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	237	Target Neighborhood Hits	193	Shared Neighborhood Hits	42
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

EEA1_HUMAN
NC score	0.194866 (rank : 112)	θ value	8.67504e-11 (rank : 46)
Query Neighborhood Hits	237	Target Neighborhood Hits	1796	Shared Neighborhood Hits	97
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

DUET_HUMAN
NC score	0.192912 (rank : 113)	θ value	7.84624e-12 (rank : 40)
Query Neighborhood Hits	237	Target Neighborhood Hits	1220	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

SOS1_MOUSE
NC score	0.191952 (rank : 114)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	237	Target Neighborhood Hits	281	Shared Neighborhood Hits	41
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TRIO_HUMAN
NC score	0.185738 (rank : 115)	θ value	6.00763e-12 (rank : 39)
Query Neighborhood Hits	237	Target Neighborhood Hits	1580	Shared Neighborhood Hits	92
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PKHA5_HUMAN
NC score	0.185605 (rank : 116)	θ value	0.00228821 (rank : 106)
Query Neighborhood Hits	237	Target Neighborhood Hits	455	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_MOUSE
NC score	0.166600 (rank : 117)	θ value	0.62314 (rank : 143)
Query Neighborhood Hits	237	Target Neighborhood Hits	202	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.161212 (rank : 118)	θ value	0.62314 (rank : 142)
Query Neighborhood Hits	237	Target Neighborhood Hits	283	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

ALS2_MOUSE
NC score	0.158432 (rank : 119)	θ value	9.29e-05 (rank : 91)
Query Neighborhood Hits	237	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CNKR1_HUMAN
NC score	0.145195 (rank : 120)	θ value	0.0330416 (rank : 117)
Query Neighborhood Hits	237	Target Neighborhood Hits	154	Shared Neighborhood Hits	35
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

ALS2_HUMAN
NC score	0.142912 (rank : 121)	θ value	0.00102713 (rank : 101)
Query Neighborhood Hits	237	Target Neighborhood Hits	121	Shared Neighborhood Hits	23
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

CNKR2_MOUSE
NC score	0.138812 (rank : 122)	θ value	0.00298849 (rank : 108)
Query Neighborhood Hits	237	Target Neighborhood Hits	197	Shared Neighborhood Hits	37
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.138328 (rank : 123)	θ value	0.00298849 (rank : 107)
Query Neighborhood Hits	237	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

SWP70_HUMAN
NC score	0.120594 (rank : 124)	θ value	0.0330416 (rank : 118)
Query Neighborhood Hits	237	Target Neighborhood Hits	973	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.117111 (rank : 125)	θ value	0.0252991 (rank : 116)
Query Neighborhood Hits	237	Target Neighborhood Hits	1097	Shared Neighborhood Hits	91
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA3_HUMAN
NC score	0.110838 (rank : 126)	θ value	0.00298849 (rank : 110)
Query Neighborhood Hits	237	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
NC score	0.110568 (rank : 127)	θ value	0.00665767 (rank : 114)
Query Neighborhood Hits	237	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

CYH3_MOUSE
NC score	0.108193 (rank : 128)	θ value	0.125558 (rank : 122)
Query Neighborhood Hits	237	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

OSBL9_HUMAN
NC score	0.102283 (rank : 129)	θ value	0.0193708 (rank : 115)
Query Neighborhood Hits	237	Target Neighborhood Hits	138	Shared Neighborhood Hits	43
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

CYH4_MOUSE
NC score	0.102054 (rank : 130)	θ value	0.0736092 (rank : 121)
Query Neighborhood Hits	237	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH4_HUMAN
NC score	0.095955 (rank : 131)	θ value	0.125558 (rank : 123)
Query Neighborhood Hits	237	Target Neighborhood Hits	135	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

RUFY3_MOUSE
NC score	0.095683 (rank : 132)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	237	Target Neighborhood Hits	579	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

PKHA2_MOUSE
NC score	0.095474 (rank : 133)	θ value	1.81305 (rank : 172)
Query Neighborhood Hits	237	Target Neighborhood Hits	116	Shared Neighborhood Hits	46
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PLEK_HUMAN
NC score	0.094945 (rank : 134)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	237	Target Neighborhood Hits	110	Shared Neighborhood Hits	50
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

RUFY3_HUMAN
NC score	0.094881 (rank : 135)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	237	Target Neighborhood Hits	594	Shared Neighborhood Hits	24
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

NCF1_HUMAN
NC score	0.093816 (rank : 136)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	237	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CYH3_HUMAN
NC score	0.090245 (rank : 137)	θ value	1.06291 (rank : 152)
Query Neighborhood Hits	237	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

SH3K1_HUMAN
NC score	0.089171 (rank : 138)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	237	Target Neighborhood Hits	341	Shared Neighborhood Hits	28
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

MTMRD_HUMAN
NC score	0.089113 (rank : 139)	θ value	0.00134147 (rank : 104)
Query Neighborhood Hits	237	Target Neighborhood Hits	135	Shared Neighborhood Hits	43
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

PLEK_MOUSE
NC score	0.088714 (rank : 140)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	237	Target Neighborhood Hits	109	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

NCF1_MOUSE
NC score	0.088575 (rank : 141)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	237	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

C43BP_MOUSE
NC score	0.088395 (rank : 142)	θ value	2.36792 (rank : 177)
Query Neighborhood Hits	237	Target Neighborhood Hits	91	Shared Neighborhood Hits	36
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OBSCN_HUMAN
NC score	0.087676 (rank : 143)	θ value	1.43324e-05 (rank : 87)
Query Neighborhood Hits	237	Target Neighborhood Hits	1931	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

C43BP_HUMAN
NC score	0.087142 (rank : 144)	θ value	2.36792 (rank : 176)
Query Neighborhood Hits	237	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CYH1_HUMAN
NC score	0.086903 (rank : 145)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	237	Target Neighborhood Hits	184	Shared Neighborhood Hits	62
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
NC score	0.084047 (rank : 146)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	237	Target Neighborhood Hits	176	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CD2AP_HUMAN
NC score	0.082395 (rank : 147)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	237	Target Neighborhood Hits	315	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.082324 (rank : 148)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	237	Target Neighborhood Hits	336	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.081187 (rank : 149)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	237	Target Neighborhood Hits	332	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CYH2_HUMAN
NC score	0.080991 (rank : 150)	θ value	5.27518 (rank : 204)
Query Neighborhood Hits	237	Target Neighborhood Hits	175	Shared Neighborhood Hits	58
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.080965 (rank : 151)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	237	Target Neighborhood Hits	171	Shared Neighborhood Hits	58
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

3BP2_HUMAN
NC score	0.080275 (rank : 152)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	237	Target Neighborhood Hits	296	Shared Neighborhood Hits	37
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA2_HUMAN
NC score	0.080025 (rank : 153)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	237	Target Neighborhood Hits	119	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

NCF2_HUMAN
NC score	0.079086 (rank : 154)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	237	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

MTMR5_HUMAN
NC score	0.078053 (rank : 155)	θ value	0.00509761 (rank : 111)
Query Neighborhood Hits	237	Target Neighborhood Hits	141	Shared Neighborhood Hits	39
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

SRBS1_MOUSE
NC score	0.077846 (rank : 156)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	237	Target Neighborhood Hits	409	Shared Neighborhood Hits	27
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

3BP2_MOUSE
NC score	0.077773 (rank : 157)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	237	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

EXOC8_HUMAN
NC score	0.076465 (rank : 158)	θ value	0.00175202 (rank : 105)
Query Neighborhood Hits	237	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IYI6, Q5TE82	Gene names	EXOC8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

PLEK2_MOUSE
NC score	0.075675 (rank : 159)	θ value	0.125558 (rank : 127)
Query Neighborhood Hits	237	Target Neighborhood Hits	96	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

SRBS1_HUMAN
NC score	0.075199 (rank : 160)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	237	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PLEK2_HUMAN
NC score	0.075021 (rank : 161)	θ value	0.0563607 (rank : 120)
Query Neighborhood Hits	237	Target Neighborhood Hits	101	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

STAM1_HUMAN
NC score	0.073312 (rank : 162)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	237	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.073033 (rank : 163)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	237	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

VINEX_HUMAN
NC score	0.072718 (rank : 164)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	237	Target Neighborhood Hits	270	Shared Neighborhood Hits	25
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCK1_HUMAN
NC score	0.072690 (rank : 165)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	237	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

VINEX_MOUSE
NC score	0.071914 (rank : 166)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	237	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

STAM2_MOUSE
NC score	0.070540 (rank : 167)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	237	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

GRAP_HUMAN
NC score	0.070486 (rank : 168)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	237	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.069947 (rank : 169)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	237	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RFFL_MOUSE
NC score	0.069922 (rank : 170)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	237	Target Neighborhood Hits	145	Shared Neighborhood Hits	32
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

STAM2_HUMAN
NC score	0.069894 (rank : 171)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	237	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

RNF34_MOUSE
NC score	0.069265 (rank : 172)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	237	Target Neighborhood Hits	160	Shared Neighborhood Hits	34
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

GRAP_MOUSE
NC score	0.068915 (rank : 173)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	237	Target Neighborhood Hits	309	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

RHG25_HUMAN
NC score	0.068837 (rank : 174)	θ value	1.81305 (rank : 174)
Query Neighborhood Hits	237	Target Neighborhood Hits	550	Shared Neighborhood Hits	67
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

NCF4_HUMAN
NC score	0.067393 (rank : 175)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	237	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

RHG25_MOUSE
NC score	0.067229 (rank : 176)	θ value	4.03905 (rank : 198)
Query Neighborhood Hits	237	Target Neighborhood Hits	492	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

NCF4_MOUSE
NC score	0.066319 (rank : 177)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	237	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

RNF34_HUMAN
NC score	0.064075 (rank : 178)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	237	Target Neighborhood Hits	153	Shared Neighborhood Hits	31
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

E41L3_HUMAN
NC score	0.063473 (rank : 179)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	237	Target Neighborhood Hits	113	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41LB_HUMAN
NC score	0.063313 (rank : 180)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	237	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

41_HUMAN
NC score	0.063186 (rank : 181)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	237	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L5_HUMAN
NC score	0.062756 (rank : 182)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	237	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.062725 (rank : 183)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	237	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

PKHA1_HUMAN
NC score	0.062335 (rank : 184)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	237	Target Neighborhood Hits	127	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

E41L3_MOUSE
NC score	0.061996 (rank : 185)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	237	Target Neighborhood Hits	250	Shared Neighborhood Hits	11
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L2_MOUSE
NC score	0.061880 (rank : 186)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	237	Target Neighborhood Hits	459	Shared Neighborhood Hits	21
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

STAC_HUMAN
NC score	0.061727 (rank : 187)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	237	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

41_MOUSE
NC score	0.061409 (rank : 188)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	237	Target Neighborhood Hits	184	Shared Neighborhood Hits	9
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

FRMD5_MOUSE
NC score	0.061301 (rank : 189)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	237	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

PKHA1_MOUSE
NC score	0.061149 (rank : 190)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	237	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

E41L1_HUMAN
NC score	0.060997 (rank : 191)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	237	Target Neighborhood Hits	180	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

GRB2_HUMAN
NC score	0.060944 (rank : 192)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	237	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

FRMD5_HUMAN
NC score	0.060893 (rank : 193)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	237	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

GRB2_MOUSE
NC score	0.060876 (rank : 194)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	237	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

CJ064_HUMAN
NC score	0.060722 (rank : 195)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	237	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

DGKH_HUMAN
NC score	0.060566 (rank : 196)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	237	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

SPTA2_HUMAN
NC score	0.060482 (rank : 197)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	237	Target Neighborhood Hits	888	Shared Neighborhood Hits	49
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

GOGA3_MOUSE
NC score	0.060366 (rank : 198)	θ value	0.0431538 (rank : 119)
Query Neighborhood Hits	237	Target Neighborhood Hits	1437	Shared Neighborhood Hits	53
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

E41L1_MOUSE
NC score	0.060190 (rank : 199)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	237	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

STAC_MOUSE
NC score	0.060163 (rank : 200)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	237	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

E41L2_HUMAN
NC score	0.059676 (rank : 201)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	237	Target Neighborhood Hits	287	Shared Neighborhood Hits	8
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

BI2L1_HUMAN
NC score	0.059079 (rank : 202)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	237	Target Neighborhood Hits	156	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

RFFL_HUMAN
NC score	0.058780 (rank : 203)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	237	Target Neighborhood Hits	175	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

TCGAP_MOUSE
NC score	0.058749 (rank : 204)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	237	Target Neighborhood Hits	409	Shared Neighborhood Hits	35
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

IQEC3_HUMAN
NC score	0.058421 (rank : 205)	θ value	0.365318 (rank : 135)
Query Neighborhood Hits	237	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

STAC3_MOUSE
NC score	0.058415 (rank : 206)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	237	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

MOES_MOUSE
NC score	0.058039 (rank : 207)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	237	Target Neighborhood Hits	923	Shared Neighborhood Hits	39
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

STAC3_HUMAN
NC score	0.057787 (rank : 208)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	237	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

RADI_HUMAN
NC score	0.057506 (rank : 209)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	237	Target Neighborhood Hits	741	Shared Neighborhood Hits	33
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

MOES_HUMAN
NC score	0.057285 (rank : 210)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	237	Target Neighborhood Hits	892	Shared Neighborhood Hits	38
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

EP15R_MOUSE
NC score	0.057040 (rank : 211)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	237	Target Neighborhood Hits	1135	Shared Neighborhood Hits	47
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

E41LA_HUMAN
NC score	0.056949 (rank : 212)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	237	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

EP15R_HUMAN
NC score	0.056830 (rank : 213)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	237	Target Neighborhood Hits	1083	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

SPTA1_HUMAN
NC score	0.056829 (rank : 214)	θ value	8.99809 (rank : 232)
Query Neighborhood Hits	237	Target Neighborhood Hits	748	Shared Neighborhood Hits	50
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RADI_MOUSE
NC score	0.056629 (rank : 215)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	237	Target Neighborhood Hits	773	Shared Neighborhood Hits	32
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

EP15_HUMAN
NC score	0.056402 (rank : 216)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	237	Target Neighborhood Hits	1021	Shared Neighborhood Hits	43
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

GRAP2_HUMAN
NC score	0.056325 (rank : 217)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	237	Target Neighborhood Hits	304	Shared Neighborhood Hits	21
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

E41LA_MOUSE
NC score	0.056311 (rank : 218)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	237	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

REPS1_MOUSE
NC score	0.056250 (rank : 219)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	237	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

CEND1_HUMAN
NC score	0.055855 (rank : 220)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	237	Target Neighborhood Hits	284	Shared Neighborhood Hits	58
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

PPIP1_HUMAN
NC score	0.055806 (rank : 221)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	237	Target Neighborhood Hits	389	Shared Neighborhood Hits	29
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

HCLS1_MOUSE
NC score	0.055730 (rank : 222)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	237	Target Neighborhood Hits	329	Shared Neighborhood Hits	23
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

GRAP2_MOUSE
NC score	0.055691 (rank : 223)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	237	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

DDEF2_MOUSE
NC score	0.055599 (rank : 224)	θ value	1.06291 (rank : 154)
Query Neighborhood Hits	237	Target Neighborhood Hits	625	Shared Neighborhood Hits	47
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.055362 (rank : 225)	θ value	1.06291 (rank : 153)
Query Neighborhood Hits	237	Target Neighborhood Hits	599	Shared Neighborhood Hits	50
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SPTA1_MOUSE
NC score	0.055185 (rank : 226)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	237	Target Neighborhood Hits	675	Shared Neighborhood Hits	46
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

HCLS1_HUMAN
NC score	0.055116 (rank : 227)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	237	Target Neighborhood Hits	358	Shared Neighborhood Hits	25
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PPIP1_MOUSE
NC score	0.054909 (rank : 228)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	237	Target Neighborhood Hits	377	Shared Neighborhood Hits	30
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

TCGAP_HUMAN
NC score	0.054871 (rank : 229)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	237	Target Neighborhood Hits	872	Shared Neighborhood Hits	38
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SRC8_HUMAN
NC score	0.054747 (rank : 230)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	237	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

MERL_MOUSE
NC score	0.054563 (rank : 231)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	237	Target Neighborhood Hits	524	Shared Neighborhood Hits	23
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

ABI2_MOUSE
NC score	0.054540 (rank : 232)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	237	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CRKL_HUMAN
NC score	0.054403 (rank : 233)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	237	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ABI2_HUMAN
NC score	0.054310 (rank : 234)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	237	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

MERL_HUMAN
NC score	0.054171 (rank : 235)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	237	Target Neighborhood Hits	532	Shared Neighborhood Hits	23
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

EZRI_HUMAN
NC score	0.054051 (rank : 236)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	237	Target Neighborhood Hits	663	Shared Neighborhood Hits	30
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

AHI1_HUMAN
NC score	0.053928 (rank : 237)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	237	Target Neighborhood Hits	537	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

RHG04_HUMAN
NC score	0.053806 (rank : 238)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	237	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

EZRI_MOUSE
NC score	0.053555 (rank : 239)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	237	Target Neighborhood Hits	693	Shared Neighborhood Hits	31
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

SRC8_MOUSE
NC score	0.053258 (rank : 240)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	237	Target Neighborhood Hits	292	Shared Neighborhood Hits	22
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

EP15_MOUSE
NC score	0.053200 (rank : 241)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	237	Target Neighborhood Hits	820	Shared Neighborhood Hits	33
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

ABI1_MOUSE
NC score	0.053093 (rank : 242)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	237	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CEND1_MOUSE
NC score	0.053073 (rank : 243)	θ value	0.813845 (rank : 146)
Query Neighborhood Hits	237	Target Neighborhood Hits	260	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

MYLIP_MOUSE
NC score	0.052951 (rank : 244)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	237	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

CRKL_MOUSE
NC score	0.052653 (rank : 245)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	237	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

MYLIP_HUMAN
NC score	0.052599 (rank : 246)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	237	Target Neighborhood Hits	162	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

PHLB2_MOUSE
NC score	0.052492 (rank : 247)	θ value	1.38821 (rank : 164)
Query Neighborhood Hits	237	Target Neighborhood Hits	1016	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

SH3G2_HUMAN
NC score	0.052065 (rank : 248)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	237	Target Neighborhood Hits	324	Shared Neighborhood Hits	28
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G1_HUMAN
NC score	0.051481 (rank : 249)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	237	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

IQEC3_MOUSE
NC score	0.051236 (rank : 250)	θ value	0.813845 (rank : 148)
Query Neighborhood Hits	237	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

SH3G3_MOUSE
NC score	0.051195 (rank : 251)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	237	Target Neighborhood Hits	236	Shared Neighborhood Hits	21
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

FNBP2_HUMAN
NC score	0.051019 (rank : 252)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	237	Target Neighborhood Hits	432	Shared Neighborhood Hits	33
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

NEBL_HUMAN
NC score	0.050934 (rank : 253)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	237	Target Neighborhood Hits	457	Shared Neighborhood Hits	33
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PLCG1_MOUSE
NC score	0.050758 (rank : 254)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	237	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G3_HUMAN
NC score	0.050391 (rank : 255)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	237	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CRK_MOUSE
NC score	0.050236 (rank : 256)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	237	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G2_MOUSE
NC score	0.050067 (rank : 257)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	237	Target Neighborhood Hits	319	Shared Neighborhood Hits	26
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SRGP1_HUMAN
NC score	0.050003 (rank : 258)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	237	Target Neighborhood Hits	390	Shared Neighborhood Hits	31
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

K1914_HUMAN
NC score	0.049163 (rank : 259)	θ value	1.81305 (rank : 171)
Query Neighborhood Hits	237	Target Neighborhood Hits	255	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

PSD4_HUMAN
NC score	0.047744 (rank : 260)	θ value	1.06291 (rank : 157)
Query Neighborhood Hits	237	Target Neighborhood Hits	178	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CEND2_HUMAN
NC score	0.047040 (rank : 261)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

NUMA1_HUMAN
NC score	0.046138 (rank : 262)	θ value	4.03905 (rank : 196)
Query Neighborhood Hits	237	Target Neighborhood Hits	1523	Shared Neighborhood Hits	57
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

KMHN1_HUMAN
NC score	0.045945 (rank : 263)	θ value	1.38821 (rank : 161)
Query Neighborhood Hits	237	Target Neighborhood Hits	950	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

OSB11_MOUSE
NC score	0.044821 (rank : 264)	θ value	1.38821 (rank : 163)
Query Neighborhood Hits	237	Target Neighborhood Hits	71	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

SPTB2_HUMAN
NC score	0.044693 (rank : 265)	θ value	0.163984 (rank : 129)
Query Neighborhood Hits	237	Target Neighborhood Hits	748	Shared Neighborhood Hits	49
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.043449 (rank : 266)	θ value	0.813845 (rank : 151)
Query Neighborhood Hits	237	Target Neighborhood Hits	770	Shared Neighborhood Hits	53
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

OSBP1_HUMAN
NC score	0.041321 (rank : 267)	θ value	8.99809 (rank : 229)
Query Neighborhood Hits	237	Target Neighborhood Hits	180	Shared Neighborhood Hits	47
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

FSTL1_MOUSE
NC score	0.041294 (rank : 268)	θ value	0.21417 (rank : 130)
Query Neighborhood Hits	237	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

FSTL1_HUMAN
NC score	0.040297 (rank : 269)	θ value	0.279714 (rank : 132)
Query Neighborhood Hits	237	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

TMF1_HUMAN
NC score	0.036177 (rank : 270)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	237	Target Neighborhood Hits	987	Shared Neighborhood Hits	40
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

DSPP_MOUSE
NC score	0.035944 (rank : 271)	θ value	0.163984 (rank : 128)
Query Neighborhood Hits	237	Target Neighborhood Hits	491	Shared Neighborhood Hits	22
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DSPP_HUMAN
NC score	0.035799 (rank : 272)	θ value	0.125558 (rank : 125)
Query Neighborhood Hits	237	Target Neighborhood Hits	645	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DDFL1_HUMAN
NC score	0.033727 (rank : 273)	θ value	0.125558 (rank : 124)
Query Neighborhood Hits	237	Target Neighborhood Hits	353	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

TACC2_HUMAN
NC score	0.033584 (rank : 274)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	237	Target Neighborhood Hits	856	Shared Neighborhood Hits	31
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

CEP35_HUMAN
NC score	0.032793 (rank : 275)	θ value	3.0926 (rank : 182)
Query Neighborhood Hits	237	Target Neighborhood Hits	811	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

ZN318_HUMAN
NC score	0.031622 (rank : 276)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	237	Target Neighborhood Hits	497	Shared Neighborhood Hits	24
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

RASA3_HUMAN
NC score	0.031422 (rank : 277)	θ value	3.0926 (rank : 186)
Query Neighborhood Hits	237	Target Neighborhood Hits	166	Shared Neighborhood Hits	33
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA3_MOUSE
NC score	0.031392 (rank : 278)	θ value	0.62314 (rank : 144)
Query Neighborhood Hits	237	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

UACA_HUMAN
NC score	0.030745 (rank : 279)	θ value	4.03905 (rank : 199)
Query Neighborhood Hits	237	Target Neighborhood Hits	1622	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

TNR25_HUMAN
NC score	0.030151 (rank : 280)	θ value	0.365318 (rank : 136)
Query Neighborhood Hits	237	Target Neighborhood Hits	172	Shared Neighborhood Hits	4
SwissProt Accessions	Q93038, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5	Gene names	TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 25 precursor (WSL-1 protein) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death domain receptor 3) (WSL protein) (Apoptosis- inducing receptor AIR) (Apo-3) (Lymphocyte-associated receptor of death) (LARD).

DDFL1_MOUSE
NC score	0.028464 (rank : 281)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	237	Target Neighborhood Hits	324	Shared Neighborhood Hits	24
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

LIPB1_HUMAN
NC score	0.027133 (rank : 282)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	237	Target Neighborhood Hits	640	Shared Neighborhood Hits	31
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

K2002_MOUSE
NC score	0.026874 (rank : 283)	θ value	0.47712 (rank : 139)
Query Neighborhood Hits	237	Target Neighborhood Hits	267	Shared Neighborhood Hits	8
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

ANLN_HUMAN
NC score	0.026247 (rank : 284)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	237	Target Neighborhood Hits	222	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

NFM_HUMAN
NC score	0.026070 (rank : 285)	θ value	0.47712 (rank : 140)
Query Neighborhood Hits	237	Target Neighborhood Hits	1328	Shared Neighborhood Hits	50
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

FACD2_HUMAN
NC score	0.024824 (rank : 286)	θ value	1.06291 (rank : 155)
Query Neighborhood Hits	237	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXW9, Q2LA86, Q69YP9, Q6PJN7, Q9BQ06, Q9H9T9	Gene names	FANCD2
Domain Architecture	No domain graphic available
Description	Fanconi anemia group D2 protein (Protein FACD2).

NPHP3_MOUSE
NC score	0.023808 (rank : 287)	θ value	0.125558 (rank : 126)
Query Neighborhood Hits	237	Target Neighborhood Hits	335	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TNH6, Q69Z39, Q8C798, Q8C7Z3, Q9D6D1	Gene names	Nphp3, Kiaa2000
Domain Architecture	No domain graphic available
Description	Nephrocystin-3.

TAF3_MOUSE
NC score	0.022784 (rank : 288)	θ value	1.38821 (rank : 165)
Query Neighborhood Hits	237	Target Neighborhood Hits	463	Shared Neighborhood Hits	17
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

RHG05_MOUSE
NC score	0.022718 (rank : 289)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	237	Target Neighborhood Hits	165	Shared Neighborhood Hits	10
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

CJ006_MOUSE
NC score	0.022523 (rank : 290)	θ value	0.47712 (rank : 137)
Query Neighborhood Hits	237	Target Neighborhood Hits	141	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

CENA2_HUMAN
NC score	0.022268 (rank : 291)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	237	Target Neighborhood Hits	83	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

DMP1_MOUSE
NC score	0.022099 (rank : 292)	θ value	0.813845 (rank : 147)
Query Neighborhood Hits	237	Target Neighborhood Hits	498	Shared Neighborhood Hits	26
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

PARG_HUMAN
NC score	0.020139 (rank : 293)	θ value	1.06291 (rank : 156)
Query Neighborhood Hits	237	Target Neighborhood Hits	97	Shared Neighborhood Hits	10
SwissProt Accessions	Q86W56, Q6E4P6, Q6E4P7, Q7Z742, Q9Y4W7	Gene names	PARG
Domain Architecture	No domain graphic available
Description	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143).

CLSPN_HUMAN
NC score	0.018941 (rank : 294)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	237	Target Neighborhood Hits	433	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

GIT2_HUMAN
NC score	0.017653 (rank : 295)	θ value	1.38821 (rank : 160)
Query Neighborhood Hits	237	Target Neighborhood Hits	381	Shared Neighborhood Hits	20
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

CIR_MOUSE
NC score	0.017312 (rank : 296)	θ value	3.0926 (rank : 183)
Query Neighborhood Hits	237	Target Neighborhood Hits	255	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

REEP2_MOUSE
NC score	0.016692 (rank : 297)	θ value	0.62314 (rank : 145)
Query Neighborhood Hits	237	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCD6	Gene names	Reep2
Domain Architecture	No domain graphic available
Description	Receptor expression-enhancing protein 2.

SNX16_MOUSE
NC score	0.015550 (rank : 298)	θ value	1.06291 (rank : 158)
Query Neighborhood Hits	237	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C080	Gene names	Snx16
Domain Architecture	No domain graphic available
Description	Sorting nexin-16.

RC3H1_MOUSE
NC score	0.015015 (rank : 299)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	237	Target Neighborhood Hits	244	Shared Neighborhood Hits	12
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

2AAB_HUMAN
NC score	0.014847 (rank : 300)	θ value	2.36792 (rank : 175)
Query Neighborhood Hits	237	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

SP100_HUMAN
NC score	0.014788 (rank : 301)	θ value	0.21417 (rank : 131)
Query Neighborhood Hits	237	Target Neighborhood Hits	117	Shared Neighborhood Hits	2
SwissProt Accessions	P23497, O75450, Q13343, Q96F70, Q96T24, Q96T95, Q9NP33, Q9UE32	Gene names	SP100
Domain Architecture
Description	Nuclear autoantigen Sp-100 (Speckled 100 kDa) (Nuclear dot-associated Sp100 protein) (Lysp100b).

ZBED1_HUMAN
NC score	0.014252 (rank : 302)	θ value	4.03905 (rank : 200)
Query Neighborhood Hits	237	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	O96006, Q96BY4	Gene names	ZBED1, ALTE, DREF, KIAA0785, TRAMP
Domain Architecture
Description	Zinc finger BED domain-containing protein 1 (dREF homolog) (Putative Ac-like transposable element).

STAP1_HUMAN
NC score	0.013975 (rank : 303)	θ value	8.99809 (rank : 233)
Query Neighborhood Hits	237	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULZ2	Gene names	STAP1, BRDG1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1) (BCR downstream signaling protein 1) (Docking protein BRDG1).

RC3H1_HUMAN
NC score	0.013373 (rank : 304)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	237	Target Neighborhood Hits	433	Shared Neighborhood Hits	15
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

HUWE1_MOUSE
NC score	0.013104 (rank : 305)	θ value	0.365318 (rank : 134)
Query Neighborhood Hits	237	Target Neighborhood Hits	406	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ASXL1_HUMAN
NC score	0.012439 (rank : 306)	θ value	3.0926 (rank : 181)
Query Neighborhood Hits	237	Target Neighborhood Hits	260	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

CKAP5_HUMAN
NC score	0.012286 (rank : 307)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	237	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	Q14008, Q14668	Gene names	CKAP5, KIAA0097
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor over- expressed protein) (Ch-TOG protein).

HRX_HUMAN
NC score	0.012265 (rank : 308)	θ value	1.81305 (rank : 170)
Query Neighborhood Hits	237	Target Neighborhood Hits	825	Shared Neighborhood Hits	25
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

SYTL2_MOUSE
NC score	0.011726 (rank : 309)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	237	Target Neighborhood Hits	253	Shared Neighborhood Hits	16
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

MCM4_HUMAN
NC score	0.011540 (rank : 310)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	237	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

RIF1_HUMAN
NC score	0.011287 (rank : 311)	θ value	8.99809 (rank : 230)
Query Neighborhood Hits	237	Target Neighborhood Hits	320	Shared Neighborhood Hits	16
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

FMN1B_MOUSE
NC score	0.010767 (rank : 312)	θ value	0.62314 (rank : 141)
Query Neighborhood Hits	237	Target Neighborhood Hits	447	Shared Neighborhood Hits	10
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

HUWE1_HUMAN
NC score	0.010516 (rank : 313)	θ value	3.0926 (rank : 184)
Query Neighborhood Hits	237	Target Neighborhood Hits	443	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

RPTOR_MOUSE
NC score	0.009996 (rank : 314)	θ value	2.36792 (rank : 179)
Query Neighborhood Hits	237	Target Neighborhood Hits	129	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

PDE2A_MOUSE
NC score	0.009638 (rank : 315)	θ value	0.813845 (rank : 150)
Query Neighborhood Hits	237	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

SFRS4_HUMAN
NC score	0.009520 (rank : 316)	θ value	0.279714 (rank : 133)
Query Neighborhood Hits	237	Target Neighborhood Hits	384	Shared Neighborhood Hits	11
SwissProt Accessions	Q08170, Q5VXP1, Q9BUA4, Q9UEB5	Gene names	SFRS4, SRP75
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB).

BRD7_HUMAN
NC score	0.009374 (rank : 317)	θ value	1.81305 (rank : 167)
Query Neighborhood Hits	237	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPI1, Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9UH59	Gene names	BRD7, BP75, CELTIX1
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1).

NALP5_MOUSE
NC score	0.009225 (rank : 318)	θ value	0.813845 (rank : 149)
Query Neighborhood Hits	237	Target Neighborhood Hits	560	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

ZCH10_MOUSE
NC score	0.008990 (rank : 319)	θ value	8.99809 (rank : 237)
Query Neighborhood Hits	237	Target Neighborhood Hits	133	Shared Neighborhood Hits	7
SwissProt Accessions	Q9CX48	Gene names	Zcchc10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

SVIL_MOUSE
NC score	0.008632 (rank : 320)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	237	Target Neighborhood Hits	439	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

PPIG_HUMAN
NC score	0.008255 (rank : 321)	θ value	1.81305 (rank : 173)
Query Neighborhood Hits	237	Target Neighborhood Hits	670	Shared Neighborhood Hits	22
SwissProt Accessions	Q13427, O00706, Q96DG9	Gene names	PPIG
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase G (EC 5.2.1.8) (Peptidyl-prolyl isomerase G) (PPIase G) (Rotamase G) (Cyclophilin G) (Clk-associating RS-cyclophilin) (CARS-cyclophilin) (CARS-Cyp) (SR-cyclophilin) (SRcyp) (SR-cyp) (CASP10).

SEC63_MOUSE
NC score	0.007658 (rank : 322)	θ value	8.99809 (rank : 231)
Query Neighborhood Hits	237	Target Neighborhood Hits	601	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

USP9X_MOUSE
NC score	0.007376 (rank : 323)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	237	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

USP9X_HUMAN
NC score	0.007360 (rank : 324)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	237	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

EDAR_HUMAN
NC score	0.007270 (rank : 325)	θ value	6.88961 (rank : 216)
Query Neighborhood Hits	237	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

ITK_HUMAN
NC score	0.007081 (rank : 326)	θ value	0.47712 (rank : 138)
Query Neighborhood Hits	237	Target Neighborhood Hits	1016	Shared Neighborhood Hits	40
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

HS105_MOUSE
NC score	0.006660 (rank : 327)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	237	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	Q61699, Q3TNS2, Q3UIY8, Q62578, Q62579, Q6A0A5, Q8C430, Q8VCW6	Gene names	Hsph1, Hsp105, Hsp110, Kiaa0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock-related 100 kDa protein E7I) (HSP-E7I) (Heat shock 110 kDa protein) (42 degrees C-HSP).

LNX1_MOUSE
NC score	0.005669 (rank : 328)	θ value	4.03905 (rank : 195)
Query Neighborhood Hits	237	Target Neighborhood Hits	377	Shared Neighborhood Hits	8
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

CDON_MOUSE
NC score	0.005629 (rank : 329)	θ value	6.88961 (rank : 215)
Query Neighborhood Hits	237	Target Neighborhood Hits	410	Shared Neighborhood Hits	6
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

KCD13_MOUSE
NC score	0.005512 (rank : 330)	θ value	4.03905 (rank : 194)
Query Neighborhood Hits	237	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGV7, Q6AXE9	Gene names	Kctd13, Poldip1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD13 (Polymerase delta-interacting protein 1).

TGM2_MOUSE
NC score	0.005282 (rank : 331)	θ value	2.36792 (rank : 180)
Query Neighborhood Hits	237	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P21981, O88901, Q9R1F7	Gene names	Tgm2
Domain Architecture
Description	Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (TGase C) (TGC) (TG(C)) (Transglutaminase-2).

E2F2_MOUSE
NC score	0.005216 (rank : 332)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	237	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P56931, Q8BID0	Gene names	E2f2
Domain Architecture	No domain graphic available
Description	Transcription factor E2F2 (E2F-2).

TITIN_HUMAN
NC score	0.005185 (rank : 333)	θ value	3.0926 (rank : 187)
Query Neighborhood Hits	237	Target Neighborhood Hits	2923	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CHD9_HUMAN
NC score	0.005146 (rank : 334)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	237	Target Neighborhood Hits	343	Shared Neighborhood Hits	19
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

YIPF1_HUMAN
NC score	0.004864 (rank : 335)	θ value	8.99809 (rank : 236)
Query Neighborhood Hits	237	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y548, Q9NWJ1	Gene names	YIPF1
Domain Architecture	No domain graphic available
Description	Protein YIPF1 (YIP1 family member 1).

LNX1_HUMAN
NC score	0.004673 (rank : 336)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	237	Target Neighborhood Hits	379	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MAGD1_MOUSE
NC score	0.003912 (rank : 337)	θ value	3.0926 (rank : 185)
Query Neighborhood Hits	237	Target Neighborhood Hits	136	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

SMAL1_HUMAN
NC score	0.003672 (rank : 338)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	237	Target Neighborhood Hits	174	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

TBCD8_MOUSE
NC score	0.003648 (rank : 339)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	237	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z1A9	Gene names	Tbc1d8, Hblp1, Vrp
Domain Architecture
Description	TBC1 domain family member 8 (Vascular Rab-GAP/TBC-containing protein) (BUB2-like protein 1).

ATBF1_MOUSE
NC score	0.002787 (rank : 340)	θ value	6.88961 (rank : 214)
Query Neighborhood Hits	237	Target Neighborhood Hits	1841	Shared Neighborhood Hits	33
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ITAX_HUMAN
NC score	0.002685 (rank : 341)	θ value	2.36792 (rank : 178)
Query Neighborhood Hits	237	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P20702, Q8IVA6	Gene names	ITGAX, CD11C
Domain Architecture
Description	Integrin alpha-X precursor (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (Leu M5) (CD11c antigen).

MKNK1_MOUSE
NC score	0.002440 (rank : 342)	θ value	1.38821 (rank : 162)
Query Neighborhood Hits	237	Target Neighborhood Hits	811	Shared Neighborhood Hits	9
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

RBM19_HUMAN
NC score	0.001440 (rank : 343)	θ value	4.03905 (rank : 197)
Query Neighborhood Hits	237	Target Neighborhood Hits	331	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4C8, Q9BPY6, Q9UFN5	Gene names	RBM19, KIAA0682
Domain Architecture
Description	Probable RNA-binding protein 19 (RNA-binding motif protein 19).

AKT1_HUMAN
NC score	0.001319 (rank : 344)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	237	Target Neighborhood Hits	885	Shared Neighborhood Hits	32
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

CSPG2_MOUSE
NC score	0.000031 (rank : 345)	θ value	1.81305 (rank : 168)
Query Neighborhood Hits	237	Target Neighborhood Hits	711	Shared Neighborhood Hits	8
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

LRTM4_HUMAN
NC score	-0.002930 (rank : 346)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	237	Target Neighborhood Hits	279	Shared Neighborhood Hits	2
SwissProt Accessions	Q86VH4	Gene names	LRRTM4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

HIC2_MOUSE
NC score	-0.006856 (rank : 347)	θ value	1.81305 (rank : 169)
Query Neighborhood Hits	237	Target Neighborhood Hits	821	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLZ6, Q3U030, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5	Gene names	Hic2, Kiaa1020
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2).

HIC2_HUMAN
NC score	-0.007966 (rank : 348)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	237	Target Neighborhood Hits	820	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JB3, Q96KR3, Q9NSM9, Q9UPX9	Gene names	HIC2, HRG22, KIAA1020, ZBTB30
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2) (Hic-3) (HIC1-related gene on chromosome 22) (Zinc finger and BTB domain-containing protein 30).