Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : MYLIP_MOUSE

For an explanation of this page, click here

MYLIP_MOUSE
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MYLIP_HUMAN
θ value	0 (rank : 1)	NC score	0.994821 (rank : 2)
Query Neighborhood Hits	139	Target Neighborhood Hits	162	Shared Neighborhood Hits	128
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	139	Target Neighborhood Hits	139	Shared Neighborhood Hits	139
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

PTN4_HUMAN
θ value	4.42448e-31 (rank : 3)	NC score	0.615641 (rank : 33)
Query Neighborhood Hits	139	Target Neighborhood Hits	303	Shared Neighborhood Hits	50
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN3_HUMAN
θ value	3.74554e-30 (rank : 4)	NC score	0.599208 (rank : 35)
Query Neighborhood Hits	139	Target Neighborhood Hits	258	Shared Neighborhood Hits	47
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

E41L5_HUMAN
θ value	1.4233e-29 (rank : 5)	NC score	0.875980 (rank : 3)
Query Neighborhood Hits	139	Target Neighborhood Hits	76	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
θ value	2.42779e-29 (rank : 6)	NC score	0.875967 (rank : 4)
Query Neighborhood Hits	139	Target Neighborhood Hits	59	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

E41L2_HUMAN
θ value	4.14116e-29 (rank : 7)	NC score	0.846630 (rank : 16)
Query Neighborhood Hits	139	Target Neighborhood Hits	287	Shared Neighborhood Hits	47
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41LB_HUMAN
θ value	4.14116e-29 (rank : 8)	NC score	0.868753 (rank : 7)
Query Neighborhood Hits	139	Target Neighborhood Hits	79	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41L2_MOUSE
θ value	2.05525e-28 (rank : 9)	NC score	0.827261 (rank : 17)
Query Neighborhood Hits	139	Target Neighborhood Hits	459	Shared Neighborhood Hits	48
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

41_HUMAN
θ value	3.50572e-28 (rank : 10)	NC score	0.856882 (rank : 12)
Query Neighborhood Hits	139	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	5.97985e-28 (rank : 11)	NC score	0.853860 (rank : 13)
Query Neighborhood Hits	139	Target Neighborhood Hits	184	Shared Neighborhood Hits	47
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L3_MOUSE
θ value	1.02001e-27 (rank : 12)	NC score	0.849006 (rank : 15)
Query Neighborhood Hits	139	Target Neighborhood Hits	250	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L1_HUMAN
θ value	2.27234e-27 (rank : 13)	NC score	0.853416 (rank : 14)
Query Neighborhood Hits	139	Target Neighborhood Hits	180	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L3_HUMAN
θ value	3.87602e-27 (rank : 14)	NC score	0.861451 (rank : 10)
Query Neighborhood Hits	139	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L1_MOUSE
θ value	5.06226e-27 (rank : 15)	NC score	0.857963 (rank : 11)
Query Neighborhood Hits	139	Target Neighborhood Hits	106	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

RADI_HUMAN
θ value	5.06226e-27 (rank : 16)	NC score	0.705896 (rank : 27)
Query Neighborhood Hits	139	Target Neighborhood Hits	741	Shared Neighborhood Hits	54
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	5.06226e-27 (rank : 17)	NC score	0.701952 (rank : 29)
Query Neighborhood Hits	139	Target Neighborhood Hits	773	Shared Neighborhood Hits	53
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

FARP1_HUMAN
θ value	1.47289e-26 (rank : 18)	NC score	0.727054 (rank : 24)
Query Neighborhood Hits	139	Target Neighborhood Hits	241	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

EZRI_MOUSE
θ value	4.28545e-26 (rank : 19)	NC score	0.718511 (rank : 26)
Query Neighborhood Hits	139	Target Neighborhood Hits	693	Shared Neighborhood Hits	53
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

MOES_HUMAN
θ value	4.28545e-26 (rank : 20)	NC score	0.664588 (rank : 31)
Query Neighborhood Hits	139	Target Neighborhood Hits	892	Shared Neighborhood Hits	56
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

EZRI_HUMAN
θ value	1.62847e-25 (rank : 21)	NC score	0.722339 (rank : 25)
Query Neighborhood Hits	139	Target Neighborhood Hits	663	Shared Neighborhood Hits	51
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FRMD5_HUMAN
θ value	1.62847e-25 (rank : 22)	NC score	0.868798 (rank : 6)
Query Neighborhood Hits	139	Target Neighborhood Hits	55	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	2.12685e-25 (rank : 23)	NC score	0.871224 (rank : 5)
Query Neighborhood Hits	139	Target Neighborhood Hits	55	Shared Neighborhood Hits	45
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

MOES_MOUSE
θ value	2.12685e-25 (rank : 24)	NC score	0.656659 (rank : 32)
Query Neighborhood Hits	139	Target Neighborhood Hits	923	Shared Neighborhood Hits	57
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FARP2_HUMAN
θ value	1.37858e-24 (rank : 25)	NC score	0.703668 (rank : 28)
Query Neighborhood Hits	139	Target Neighborhood Hits	240	Shared Neighborhood Hits	44
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PTN14_MOUSE
θ value	1.80048e-24 (rank : 26)	NC score	0.576784 (rank : 38)
Query Neighborhood Hits	139	Target Neighborhood Hits	142	Shared Neighborhood Hits	48
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

E41LA_MOUSE
θ value	5.23862e-24 (rank : 27)	NC score	0.863646 (rank : 8)
Query Neighborhood Hits	139	Target Neighborhood Hits	85	Shared Neighborhood Hits	45
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

FARP2_MOUSE
θ value	5.23862e-24 (rank : 28)	NC score	0.695217 (rank : 30)
Query Neighborhood Hits	139	Target Neighborhood Hits	209	Shared Neighborhood Hits	44
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

E41LA_HUMAN
θ value	1.16704e-23 (rank : 29)	NC score	0.862704 (rank : 9)
Query Neighborhood Hits	139	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

PTN14_HUMAN
θ value	5.79196e-23 (rank : 30)	NC score	0.568921 (rank : 39)
Query Neighborhood Hits	139	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

MERL_HUMAN
θ value	1.29031e-22 (rank : 31)	NC score	0.755489 (rank : 20)
Query Neighborhood Hits	139	Target Neighborhood Hits	532	Shared Neighborhood Hits	54
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

PTN21_HUMAN
θ value	2.87452e-22 (rank : 32)	NC score	0.584940 (rank : 37)
Query Neighborhood Hits	139	Target Neighborhood Hits	143	Shared Neighborhood Hits	48
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

MERL_MOUSE
θ value	4.9032e-22 (rank : 33)	NC score	0.755437 (rank : 21)
Query Neighborhood Hits	139	Target Neighborhood Hits	524	Shared Neighborhood Hits	52
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

PTN21_MOUSE
θ value	1.86321e-21 (rank : 34)	NC score	0.586197 (rank : 36)
Query Neighborhood Hits	139	Target Neighborhood Hits	155	Shared Neighborhood Hits	49
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

FRM4B_MOUSE
θ value	1.80466e-16 (rank : 35)	NC score	0.763790 (rank : 19)
Query Neighborhood Hits	139	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

FRM4B_HUMAN
θ value	6.85773e-16 (rank : 36)	NC score	0.763904 (rank : 18)
Query Neighborhood Hits	139	Target Neighborhood Hits	117	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4A_HUMAN
θ value	8.38298e-14 (rank : 37)	NC score	0.751439 (rank : 23)
Query Neighborhood Hits	139	Target Neighborhood Hits	110	Shared Neighborhood Hits	46
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_MOUSE
θ value	1.09485e-13 (rank : 38)	NC score	0.752199 (rank : 22)
Query Neighborhood Hits	139	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

BIRC3_MOUSE
θ value	5.08577e-11 (rank : 39)	NC score	0.263890 (rank : 50)
Query Neighborhood Hits	139	Target Neighborhood Hits	113	Shared Neighborhood Hits	58
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

PTN13_MOUSE
θ value	6.64225e-11 (rank : 40)	NC score	0.442291 (rank : 42)
Query Neighborhood Hits	139	Target Neighborhood Hits	426	Shared Neighborhood Hits	52
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

BIRC8_HUMAN
θ value	8.11959e-09 (rank : 41)	NC score	0.276066 (rank : 48)
Query Neighborhood Hits	139	Target Neighborhood Hits	121	Shared Neighborhood Hits	56
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

PTN13_HUMAN
θ value	8.11959e-09 (rank : 42)	NC score	0.430246 (rank : 43)
Query Neighborhood Hits	139	Target Neighborhood Hits	471	Shared Neighborhood Hits	48
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

BIRC7_HUMAN
θ value	5.26297e-08 (rank : 43)	NC score	0.264540 (rank : 49)
Query Neighborhood Hits	139	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC3_HUMAN
θ value	1.17247e-07 (rank : 44)	NC score	0.255391 (rank : 51)
Query Neighborhood Hits	139	Target Neighborhood Hits	133	Shared Neighborhood Hits	58
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC2_MOUSE
θ value	3.41135e-07 (rank : 45)	NC score	0.252590 (rank : 53)
Query Neighborhood Hits	139	Target Neighborhood Hits	137	Shared Neighborhood Hits	59
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

FRMD1_HUMAN
θ value	3.41135e-07 (rank : 46)	NC score	0.605742 (rank : 34)
Query Neighborhood Hits	139	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

BIRC2_HUMAN
θ value	4.45536e-07 (rank : 47)	NC score	0.252038 (rank : 55)
Query Neighborhood Hits	139	Target Neighborhood Hits	142	Shared Neighborhood Hits	57
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC4_HUMAN
θ value	2.44474e-05 (rank : 48)	NC score	0.241142 (rank : 58)
Query Neighborhood Hits	139	Target Neighborhood Hits	89	Shared Neighborhood Hits	50
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	2.44474e-05 (rank : 49)	NC score	0.239332 (rank : 59)
Query Neighborhood Hits	139	Target Neighborhood Hits	89	Shared Neighborhood Hits	49
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

RFFL_HUMAN
θ value	2.44474e-05 (rank : 50)	NC score	0.248285 (rank : 57)
Query Neighborhood Hits	139	Target Neighborhood Hits	175	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	2.44474e-05 (rank : 51)	NC score	0.251798 (rank : 56)
Query Neighborhood Hits	139	Target Neighborhood Hits	145	Shared Neighborhood Hits	56
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_HUMAN
θ value	3.19293e-05 (rank : 52)	NC score	0.254620 (rank : 52)
Query Neighborhood Hits	139	Target Neighborhood Hits	153	Shared Neighborhood Hits	58
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	3.19293e-05 (rank : 53)	NC score	0.252113 (rank : 54)
Query Neighborhood Hits	139	Target Neighborhood Hits	160	Shared Neighborhood Hits	57
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

MIB1_MOUSE
θ value	5.44631e-05 (rank : 54)	NC score	0.093618 (rank : 116)
Query Neighborhood Hits	139	Target Neighborhood Hits	471	Shared Neighborhood Hits	56
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB1_HUMAN
θ value	0.000121331 (rank : 55)	NC score	0.092155 (rank : 121)
Query Neighborhood Hits	139	Target Neighborhood Hits	470	Shared Neighborhood Hits	56
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB2_HUMAN
θ value	0.000461057 (rank : 56)	NC score	0.088272 (rank : 122)
Query Neighborhood Hits	139	Target Neighborhood Hits	438	Shared Neighborhood Hits	45
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

RKHD1_HUMAN
θ value	0.000461057 (rank : 57)	NC score	0.218769 (rank : 60)
Query Neighborhood Hits	139	Target Neighborhood Hits	163	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

TLN1_HUMAN
θ value	0.000602161 (rank : 58)	NC score	0.379201 (rank : 44)
Query Neighborhood Hits	139	Target Neighborhood Hits	218	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

CGRF1_HUMAN
θ value	0.000786445 (rank : 59)	NC score	0.210203 (rank : 62)
Query Neighborhood Hits	139	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

LRSM1_MOUSE
θ value	0.00134147 (rank : 60)	NC score	0.118765 (rank : 69)
Query Neighborhood Hits	139	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

TLN1_MOUSE
θ value	0.00134147 (rank : 61)	NC score	0.375017 (rank : 45)
Query Neighborhood Hits	139	Target Neighborhood Hits	213	Shared Neighborhood Hits	48
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

PEX10_HUMAN
θ value	0.00175202 (rank : 62)	NC score	0.125801 (rank : 68)
Query Neighborhood Hits	139	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

CGRF1_MOUSE
θ value	0.00390308 (rank : 63)	NC score	0.199408 (rank : 63)
Query Neighborhood Hits	139	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

LRSM1_HUMAN
θ value	0.00390308 (rank : 64)	NC score	0.115349 (rank : 76)
Query Neighborhood Hits	139	Target Neighborhood Hits	1078	Shared Neighborhood Hits	61
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

UHRF1_MOUSE
θ value	0.00390308 (rank : 65)	NC score	0.084056 (rank : 126)
Query Neighborhood Hits	139	Target Neighborhood Hits	278	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

TLN2_MOUSE
θ value	0.00665767 (rank : 66)	NC score	0.368884 (rank : 46)
Query Neighborhood Hits	139	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

UHRF2_MOUSE
θ value	0.00869519 (rank : 67)	NC score	0.084520 (rank : 124)
Query Neighborhood Hits	139	Target Neighborhood Hits	275	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

TLN2_HUMAN
θ value	0.0113563 (rank : 68)	NC score	0.363703 (rank : 47)
Query Neighborhood Hits	139	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

MIB2_MOUSE
θ value	0.0148317 (rank : 69)	NC score	0.085844 (rank : 123)
Query Neighborhood Hits	139	Target Neighborhood Hits	409	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

NEURL_MOUSE
θ value	0.0193708 (rank : 70)	NC score	0.169579 (rank : 64)
Query Neighborhood Hits	139	Target Neighborhood Hits	106	Shared Neighborhood Hits	54
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

UHRF2_HUMAN
θ value	0.0330416 (rank : 71)	NC score	0.081299 (rank : 132)
Query Neighborhood Hits	139	Target Neighborhood Hits	269	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

MYO10_HUMAN
θ value	0.0431538 (rank : 72)	NC score	0.046020 (rank : 197)
Query Neighborhood Hits	139	Target Neighborhood Hits	920	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

NEUL1_HUMAN
θ value	0.0431538 (rank : 73)	NC score	0.165023 (rank : 65)
Query Neighborhood Hits	139	Target Neighborhood Hits	114	Shared Neighborhood Hits	55
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

RNF26_HUMAN
θ value	0.0431538 (rank : 74)	NC score	0.214147 (rank : 61)
Query Neighborhood Hits	139	Target Neighborhood Hits	95	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

TRI35_HUMAN
θ value	0.0736092 (rank : 75)	NC score	0.059178 (rank : 166)
Query Neighborhood Hits	139	Target Neighborhood Hits	382	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

ZC3H5_MOUSE
θ value	0.0736092 (rank : 76)	NC score	0.076665 (rank : 141)
Query Neighborhood Hits	139	Target Neighborhood Hits	136	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

CBLB_HUMAN
θ value	0.0961366 (rank : 77)	NC score	0.112257 (rank : 78)
Query Neighborhood Hits	139	Target Neighborhood Hits	261	Shared Neighborhood Hits	62
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBLB_MOUSE
θ value	0.0961366 (rank : 78)	NC score	0.112470 (rank : 77)
Query Neighborhood Hits	139	Target Neighborhood Hits	277	Shared Neighborhood Hits	62
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBLC_MOUSE
θ value	0.0961366 (rank : 79)	NC score	0.118498 (rank : 70)
Query Neighborhood Hits	139	Target Neighborhood Hits	186	Shared Neighborhood Hits	59
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

MYO7A_HUMAN
θ value	0.0961366 (rank : 80)	NC score	0.059973 (rank : 163)
Query Neighborhood Hits	139	Target Neighborhood Hits	209	Shared Neighborhood Hits	28
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

CBL_HUMAN
θ value	0.125558 (rank : 81)	NC score	0.111302 (rank : 83)
Query Neighborhood Hits	139	Target Neighborhood Hits	353	Shared Neighborhood Hits	65
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
θ value	0.125558 (rank : 82)	NC score	0.108739 (rank : 84)
Query Neighborhood Hits	139	Target Neighborhood Hits	426	Shared Neighborhood Hits	66
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

MYO7A_MOUSE
θ value	0.125558 (rank : 83)	NC score	0.060303 (rank : 162)
Query Neighborhood Hits	139	Target Neighborhood Hits	235	Shared Neighborhood Hits	26
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MGRN1_HUMAN
θ value	0.21417 (rank : 84)	NC score	0.138087 (rank : 67)
Query Neighborhood Hits	139	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MGRN1_MOUSE
θ value	0.21417 (rank : 85)	NC score	0.142484 (rank : 66)
Query Neighborhood Hits	139	Target Neighborhood Hits	149	Shared Neighborhood Hits	54
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

TRI35_MOUSE
θ value	0.21417 (rank : 86)	NC score	0.062162 (rank : 159)
Query Neighborhood Hits	139	Target Neighborhood Hits	465	Shared Neighborhood Hits	70
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

ZC3H5_HUMAN
θ value	0.21417 (rank : 87)	NC score	0.072629 (rank : 142)
Query Neighborhood Hits	139	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

NALP6_MOUSE
θ value	0.279714 (rank : 88)	NC score	0.014802 (rank : 215)
Query Neighborhood Hits	139	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

CBLC_HUMAN
θ value	0.365318 (rank : 89)	NC score	0.111400 (rank : 82)
Query Neighborhood Hits	139	Target Neighborhood Hits	173	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

TRI37_HUMAN
θ value	0.365318 (rank : 90)	NC score	0.061842 (rank : 160)
Query Neighborhood Hits	139	Target Neighborhood Hits	307	Shared Neighborhood Hits	44
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	0.365318 (rank : 91)	NC score	0.062768 (rank : 157)
Query Neighborhood Hits	139	Target Neighborhood Hits	316	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

MUC5B_HUMAN
θ value	0.47712 (rank : 92)	NC score	0.012742 (rank : 216)
Query Neighborhood Hits	139	Target Neighborhood Hits	1020	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

TRIM2_HUMAN
θ value	0.47712 (rank : 93)	NC score	0.054077 (rank : 176)
Query Neighborhood Hits	139	Target Neighborhood Hits	330	Shared Neighborhood Hits	56
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

UHRF1_HUMAN
θ value	0.47712 (rank : 94)	NC score	0.068722 (rank : 145)
Query Neighborhood Hits	139	Target Neighborhood Hits	272	Shared Neighborhood Hits	40
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

LNX2_HUMAN
θ value	0.62314 (rank : 95)	NC score	0.053337 (rank : 178)
Query Neighborhood Hits	139	Target Neighborhood Hits	389	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

RO52_HUMAN
θ value	0.62314 (rank : 96)	NC score	0.054114 (rank : 175)
Query Neighborhood Hits	139	Target Neighborhood Hits	419	Shared Neighborhood Hits	71
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

TRI12_MOUSE
θ value	0.62314 (rank : 97)	NC score	0.054903 (rank : 173)
Query Neighborhood Hits	139	Target Neighborhood Hits	387	Shared Neighborhood Hits	59
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

TRIM2_MOUSE
θ value	0.62314 (rank : 98)	NC score	0.053179 (rank : 179)
Query Neighborhood Hits	139	Target Neighborhood Hits	331	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

TRAF7_MOUSE
θ value	0.813845 (rank : 99)	NC score	0.025974 (rank : 209)
Query Neighborhood Hits	139	Target Neighborhood Hits	470	Shared Neighborhood Hits	45
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

HMDH_MOUSE
θ value	1.06291 (rank : 100)	NC score	0.029410 (rank : 207)
Query Neighborhood Hits	139	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

TRAF7_HUMAN
θ value	1.06291 (rank : 101)	NC score	0.025840 (rank : 210)
Query Neighborhood Hits	139	Target Neighborhood Hits	482	Shared Neighborhood Hits	45
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

TRI27_MOUSE
θ value	1.38821 (rank : 102)	NC score	0.042998 (rank : 198)
Query Neighborhood Hits	139	Target Neighborhood Hits	261	Shared Neighborhood Hits	65
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRI32_HUMAN
θ value	1.38821 (rank : 103)	NC score	0.050869 (rank : 190)
Query Neighborhood Hits	139	Target Neighborhood Hits	264	Shared Neighborhood Hits	46
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	1.38821 (rank : 104)	NC score	0.056872 (rank : 168)
Query Neighborhood Hits	139	Target Neighborhood Hits	271	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

ZN142_HUMAN
θ value	1.38821 (rank : 105)	NC score	-0.004873 (rank : 222)
Query Neighborhood Hits	139	Target Neighborhood Hits	1007	Shared Neighborhood Hits	4
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

BRE1B_HUMAN
θ value	1.81305 (rank : 106)	NC score	0.040162 (rank : 201)
Query Neighborhood Hits	139	Target Neighborhood Hits	1040	Shared Neighborhood Hits	53
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	1.81305 (rank : 107)	NC score	0.042027 (rank : 200)
Query Neighborhood Hits	139	Target Neighborhood Hits	970	Shared Neighborhood Hits	53
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

FRAS1_MOUSE
θ value	1.81305 (rank : 108)	NC score	0.005377 (rank : 219)
Query Neighborhood Hits	139	Target Neighborhood Hits	747	Shared Neighborhood Hits	8
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

MDM2_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.067795 (rank : 150)
Query Neighborhood Hits	139	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MDM4_HUMAN
θ value	1.81305 (rank : 110)	NC score	0.072520 (rank : 143)
Query Neighborhood Hits	139	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

RNF8_MOUSE
θ value	1.81305 (rank : 111)	NC score	0.077358 (rank : 140)
Query Neighborhood Hits	139	Target Neighborhood Hits	618	Shared Neighborhood Hits	75
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

K2002_MOUSE
θ value	2.36792 (rank : 112)	NC score	0.010149 (rank : 217)
Query Neighborhood Hits	139	Target Neighborhood Hits	267	Shared Neighborhood Hits	3
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

LNX2_MOUSE
θ value	2.36792 (rank : 113)	NC score	0.048614 (rank : 194)
Query Neighborhood Hits	139	Target Neighborhood Hits	407	Shared Neighborhood Hits	48
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

PML_MOUSE
θ value	2.36792 (rank : 114)	NC score	0.042628 (rank : 199)
Query Neighborhood Hits	139	Target Neighborhood Hits	246	Shared Neighborhood Hits	43
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

RN168_HUMAN
θ value	2.36792 (rank : 115)	NC score	0.077496 (rank : 139)
Query Neighborhood Hits	139	Target Neighborhood Hits	370	Shared Neighborhood Hits	69
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI42_HUMAN
θ value	2.36792 (rank : 116)	NC score	0.031305 (rank : 205)
Query Neighborhood Hits	139	Target Neighborhood Hits	283	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI50_HUMAN
θ value	2.36792 (rank : 117)	NC score	0.046847 (rank : 196)
Query Neighborhood Hits	139	Target Neighborhood Hits	294	Shared Neighborhood Hits	68
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

RN123_MOUSE
θ value	3.0926 (rank : 118)	NC score	0.054269 (rank : 174)
Query Neighborhood Hits	139	Target Neighborhood Hits	174	Shared Neighborhood Hits	45
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

RO52_MOUSE
θ value	3.0926 (rank : 119)	NC score	0.048675 (rank : 193)
Query Neighborhood Hits	139	Target Neighborhood Hits	360	Shared Neighborhood Hits	68
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

TRI27_HUMAN
θ value	4.03905 (rank : 120)	NC score	0.038380 (rank : 202)
Query Neighborhood Hits	139	Target Neighborhood Hits	273	Shared Neighborhood Hits	64
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

TRI56_HUMAN
θ value	4.03905 (rank : 121)	NC score	0.053415 (rank : 177)
Query Neighborhood Hits	139	Target Neighborhood Hits	339	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

TRI56_MOUSE
θ value	4.03905 (rank : 122)	NC score	0.052244 (rank : 184)
Query Neighborhood Hits	139	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

PML_HUMAN
θ value	5.27518 (rank : 123)	NC score	0.047283 (rank : 195)
Query Neighborhood Hits	139	Target Neighborhood Hits	248	Shared Neighborhood Hits	42
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

RFWD2_HUMAN
θ value	5.27518 (rank : 124)	NC score	0.030001 (rank : 206)
Query Neighborhood Hits	139	Target Neighborhood Hits	518	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RFWD2_MOUSE
θ value	5.27518 (rank : 125)	NC score	0.031530 (rank : 204)
Query Neighborhood Hits	139	Target Neighborhood Hits	535	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RN123_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.051267 (rank : 187)
Query Neighborhood Hits	139	Target Neighborhood Hits	175	Shared Neighborhood Hits	43
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRI42_MOUSE
θ value	5.27518 (rank : 127)	NC score	0.029329 (rank : 208)
Query Neighborhood Hits	139	Target Neighborhood Hits	316	Shared Neighborhood Hits	41
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

CNOT4_HUMAN
θ value	6.88961 (rank : 128)	NC score	0.021294 (rank : 211)
Query Neighborhood Hits	139	Target Neighborhood Hits	207	Shared Neighborhood Hits	18
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CNOT4_MOUSE
θ value	6.88961 (rank : 129)	NC score	0.020354 (rank : 212)
Query Neighborhood Hits	139	Target Neighborhood Hits	277	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

LNX1_HUMAN
θ value	6.88961 (rank : 130)	NC score	0.037487 (rank : 203)
Query Neighborhood Hits	139	Target Neighborhood Hits	379	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

RN168_MOUSE
θ value	6.88961 (rank : 131)	NC score	0.063656 (rank : 155)
Query Neighborhood Hits	139	Target Neighborhood Hits	440	Shared Neighborhood Hits	65
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

SPI2_HUMAN
θ value	6.88961 (rank : 132)	NC score	0.000006 (rank : 221)
Query Neighborhood Hits	139	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	O75830	Gene names	SERPINI2, MEPI, PI14
Domain Architecture
Description	Serpin I2 precursor (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Protease inhibitor 14) (TSA2004).

TRI31_HUMAN
θ value	6.88961 (rank : 133)	NC score	0.056274 (rank : 170)
Query Neighborhood Hits	139	Target Neighborhood Hits	299	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

TRI50_MOUSE
θ value	6.88961 (rank : 134)	NC score	0.049677 (rank : 192)
Query Neighborhood Hits	139	Target Neighborhood Hits	326	Shared Neighborhood Hits	73
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

HMDH_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.017041 (rank : 214)
Query Neighborhood Hits	139	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

NALP6_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.009437 (rank : 218)
Query Neighborhood Hits	139	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

RNF24_MOUSE
θ value	8.99809 (rank : 137)	NC score	0.019133 (rank : 213)
Query Neighborhood Hits	139	Target Neighborhood Hits	124	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BGI1	Gene names	Rnf24
Domain Architecture	No domain graphic available
Description	RING finger protein 24.

TITIN_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.003614 (rank : 220)
Query Neighborhood Hits	139	Target Neighborhood Hits	2923	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ZN646_HUMAN
θ value	8.99809 (rank : 139)	NC score	-0.006057 (rank : 223)
Query Neighborhood Hits	139	Target Neighborhood Hits	813	Shared Neighborhood Hits	3
SwissProt Accessions	O15015	Gene names	ZNF646, KIAA0296
Domain Architecture	No domain graphic available
Description	Zinc finger protein 646.

BIR1A_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.067369 (rank : 151)
Query Neighborhood Hits	139	Target Neighborhood Hits	94	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1B_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.068581 (rank : 147)
Query Neighborhood Hits	139	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1E_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.068686 (rank : 146)
Query Neighborhood Hits	139	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.068494 (rank : 148)
Query Neighborhood Hits	139	Target Neighborhood Hits	88	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.068290 (rank : 149)
Query Neighborhood Hits	139	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIRC1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.069055 (rank : 144)
Query Neighborhood Hits	139	Target Neighborhood Hits	61	Shared Neighborhood Hits	10
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIRC5_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.077985 (rank : 138)
Query Neighborhood Hits	139	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.083100 (rank : 130)
Query Neighborhood Hits	139	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

CA106_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.096013 (rank : 114)
Query Neighborhood Hits	139	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CA106_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.094413 (rank : 115)
Query Neighborhood Hits	139	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CCD50_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.050982 (rank : 189)
Query Neighborhood Hits	139	Target Neighborhood Hits	237	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IVM0, Q86VH7	Gene names	CCDC50, C3orf6
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

CD45_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.097552 (rank : 112)
Query Neighborhood Hits	139	Target Neighborhood Hits	243	Shared Neighborhood Hits	10
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.101403 (rank : 101)
Query Neighborhood Hits	139	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

FGD4_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.050863 (rank : 191)
Query Neighborhood Hits	139	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.051153 (rank : 188)
Query Neighborhood Hits	139	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD5_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.056116 (rank : 171)
Query Neighborhood Hits	139	Target Neighborhood Hits	235	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.053176 (rank : 180)
Query Neighborhood Hits	139	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.052951 (rank : 182)
Query Neighborhood Hits	139	Target Neighborhood Hits	237	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.052548 (rank : 183)
Query Neighborhood Hits	139	Target Neighborhood Hits	282	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FRMD6_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.561249 (rank : 41)
Query Neighborhood Hits	139	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

FRMD6_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.567280 (rank : 40)
Query Neighborhood Hits	139	Target Neighborhood Hits	63	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

HIP1R_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.052214 (rank : 185)
Query Neighborhood Hits	139	Target Neighborhood Hits	809	Shared Neighborhood Hits	19
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

HIP1_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.055807 (rank : 172)
Query Neighborhood Hits	139	Target Neighborhood Hits	1016	Shared Neighborhood Hits	27
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

KRIT1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.103003 (rank : 98)
Query Neighborhood Hits	139	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

KRIT1_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.096286 (rank : 113)
Query Neighborhood Hits	139	Target Neighborhood Hits	258	Shared Neighborhood Hits	27
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

PTN11_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.100066 (rank : 106)
Query Neighborhood Hits	139	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.100067 (rank : 105)
Query Neighborhood Hits	139	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN12_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.106555 (rank : 91)
Query Neighborhood Hits	139	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.106242 (rank : 92)
Query Neighborhood Hits	139	Target Neighborhood Hits	123	Shared Neighborhood Hits	8
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN18_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.115542 (rank : 74)
Query Neighborhood Hits	139	Target Neighborhood Hits	73	Shared Neighborhood Hits	8
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.112017 (rank : 80)
Query Neighborhood Hits	139	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN1_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.115650 (rank : 73)
Query Neighborhood Hits	139	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.116001 (rank : 72)
Query Neighborhood Hits	139	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN22_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.108713 (rank : 85)
Query Neighborhood Hits	139	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.107220 (rank : 87)
Query Neighborhood Hits	139	Target Neighborhood Hits	179	Shared Neighborhood Hits	9
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.099129 (rank : 109)
Query Neighborhood Hits	139	Target Neighborhood Hits	646	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.097714 (rank : 111)
Query Neighborhood Hits	139	Target Neighborhood Hits	726	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN2_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.115466 (rank : 75)
Query Neighborhood Hits	139	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.116685 (rank : 71)
Query Neighborhood Hits	139	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN5_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.100464 (rank : 104)
Query Neighborhood Hits	139	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.100564 (rank : 103)
Query Neighborhood Hits	139	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN6_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.106775 (rank : 89)
Query Neighborhood Hits	139	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.106756 (rank : 90)
Query Neighborhood Hits	139	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.106841 (rank : 88)
Query Neighborhood Hits	139	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.108014 (rank : 86)
Query Neighborhood Hits	139	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.112250 (rank : 79)
Query Neighborhood Hits	139	Target Neighborhood Hits	79	Shared Neighborhood Hits	8
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.111898 (rank : 81)
Query Neighborhood Hits	139	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPR2_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.103581 (rank : 96)
Query Neighborhood Hits	139	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.103726 (rank : 95)
Query Neighborhood Hits	139	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRA_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.093525 (rank : 117)
Query Neighborhood Hits	139	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.093481 (rank : 118)
Query Neighborhood Hits	139	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRB_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.097874 (rank : 110)
Query Neighborhood Hits	139	Target Neighborhood Hits	242	Shared Neighborhood Hits	9
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRD_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.064697 (rank : 154)
Query Neighborhood Hits	139	Target Neighborhood Hits	485	Shared Neighborhood Hits	11
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.062177 (rank : 158)
Query Neighborhood Hits	139	Target Neighborhood Hits	491	Shared Neighborhood Hits	10
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRE_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.093475 (rank : 119)
Query Neighborhood Hits	139	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.092912 (rank : 120)
Query Neighborhood Hits	139	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRF_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.062823 (rank : 156)
Query Neighborhood Hits	139	Target Neighborhood Hits	489	Shared Neighborhood Hits	9
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRG_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.083006 (rank : 131)
Query Neighborhood Hits	139	Target Neighborhood Hits	231	Shared Neighborhood Hits	9
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.083331 (rank : 129)
Query Neighborhood Hits	139	Target Neighborhood Hits	260	Shared Neighborhood Hits	11
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRJ_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.099956 (rank : 107)
Query Neighborhood Hits	139	Target Neighborhood Hits	207	Shared Neighborhood Hits	9
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.100592 (rank : 102)
Query Neighborhood Hits	139	Target Neighborhood Hits	188	Shared Neighborhood Hits	10
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRK_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.083588 (rank : 128)
Query Neighborhood Hits	139	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.084277 (rank : 125)
Query Neighborhood Hits	139	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRM_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.078561 (rank : 137)
Query Neighborhood Hits	139	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.078973 (rank : 135)
Query Neighborhood Hits	139	Target Neighborhood Hits	238	Shared Neighborhood Hits	9
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRN_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.104079 (rank : 94)
Query Neighborhood Hits	139	Target Neighborhood Hits	156	Shared Neighborhood Hits	11
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.103553 (rank : 97)
Query Neighborhood Hits	139	Target Neighborhood Hits	240	Shared Neighborhood Hits	9
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRO_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.104411 (rank : 93)
Query Neighborhood Hits	139	Target Neighborhood Hits	139	Shared Neighborhood Hits	9
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRR_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.102059 (rank : 100)
Query Neighborhood Hits	139	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.102595 (rank : 99)
Query Neighborhood Hits	139	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRS_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.066095 (rank : 153)
Query Neighborhood Hits	139	Target Neighborhood Hits	472	Shared Neighborhood Hits	10
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRT_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.080726 (rank : 133)
Query Neighborhood Hits	139	Target Neighborhood Hits	217	Shared Neighborhood Hits	9
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.080683 (rank : 134)
Query Neighborhood Hits	139	Target Neighborhood Hits	219	Shared Neighborhood Hits	9
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRU_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.078743 (rank : 136)
Query Neighborhood Hits	139	Target Neighborhood Hits	237	Shared Neighborhood Hits	9
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRV_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.099571 (rank : 108)
Query Neighborhood Hits	139	Target Neighborhood Hits	179	Shared Neighborhood Hits	9
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTPRZ_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.083727 (rank : 127)
Query Neighborhood Hits	139	Target Neighborhood Hits	255	Shared Neighborhood Hits	9
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

RN169_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.060752 (rank : 161)
Query Neighborhood Hits	139	Target Neighborhood Hits	203	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

RN185_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.059906 (rank : 164)
Query Neighborhood Hits	139	Target Neighborhood Hits	213	Shared Neighborhood Hits	57
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.059327 (rank : 165)
Query Neighborhood Hits	139	Target Neighborhood Hits	211	Shared Neighborhood Hits	57
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RNF5_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.052990 (rank : 181)
Query Neighborhood Hits	139	Target Neighborhood Hits	206	Shared Neighborhood Hits	62
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RNF5_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.052210 (rank : 186)
Query Neighborhood Hits	139	Target Neighborhood Hits	206	Shared Neighborhood Hits	62
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

RNF8_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.066521 (rank : 152)
Query Neighborhood Hits	139	Target Neighborhood Hits	622	Shared Neighborhood Hits	71
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

TRI26_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.056435 (rank : 169)
Query Neighborhood Hits	139	Target Neighborhood Hits	335	Shared Neighborhood Hits	71
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI26_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.057196 (rank : 167)
Query Neighborhood Hits	139	Target Neighborhood Hits	339	Shared Neighborhood Hits	71
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

Hits sorted by NC score

MYLIP_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	139	Target Neighborhood Hits	139	Shared Neighborhood Hits	139
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_HUMAN
NC score	0.994821 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	139	Target Neighborhood Hits	162	Shared Neighborhood Hits	128
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

E41L5_HUMAN
NC score	0.875980 (rank : 3)	θ value	1.4233e-29 (rank : 5)
Query Neighborhood Hits	139	Target Neighborhood Hits	76	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.875967 (rank : 4)	θ value	2.42779e-29 (rank : 6)
Query Neighborhood Hits	139	Target Neighborhood Hits	59	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

FRMD5_MOUSE
NC score	0.871224 (rank : 5)	θ value	2.12685e-25 (rank : 23)
Query Neighborhood Hits	139	Target Neighborhood Hits	55	Shared Neighborhood Hits	45
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_HUMAN
NC score	0.868798 (rank : 6)	θ value	1.62847e-25 (rank : 22)
Query Neighborhood Hits	139	Target Neighborhood Hits	55	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41LB_HUMAN
NC score	0.868753 (rank : 7)	θ value	4.14116e-29 (rank : 8)
Query Neighborhood Hits	139	Target Neighborhood Hits	79	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LA_MOUSE
NC score	0.863646 (rank : 8)	θ value	5.23862e-24 (rank : 27)
Query Neighborhood Hits	139	Target Neighborhood Hits	85	Shared Neighborhood Hits	45
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_HUMAN
NC score	0.862704 (rank : 9)	θ value	1.16704e-23 (rank : 29)
Query Neighborhood Hits	139	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41L3_HUMAN
NC score	0.861451 (rank : 10)	θ value	3.87602e-27 (rank : 14)
Query Neighborhood Hits	139	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L1_MOUSE
NC score	0.857963 (rank : 11)	θ value	5.06226e-27 (rank : 15)
Query Neighborhood Hits	139	Target Neighborhood Hits	106	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

41_HUMAN
NC score	0.856882 (rank : 12)	θ value	3.50572e-28 (rank : 10)
Query Neighborhood Hits	139	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
NC score	0.853860 (rank : 13)	θ value	5.97985e-28 (rank : 11)
Query Neighborhood Hits	139	Target Neighborhood Hits	184	Shared Neighborhood Hits	47
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L1_HUMAN
NC score	0.853416 (rank : 14)	θ value	2.27234e-27 (rank : 13)
Query Neighborhood Hits	139	Target Neighborhood Hits	180	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L3_MOUSE
NC score	0.849006 (rank : 15)	θ value	1.02001e-27 (rank : 12)
Query Neighborhood Hits	139	Target Neighborhood Hits	250	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L2_HUMAN
NC score	0.846630 (rank : 16)	θ value	4.14116e-29 (rank : 7)
Query Neighborhood Hits	139	Target Neighborhood Hits	287	Shared Neighborhood Hits	47
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
NC score	0.827261 (rank : 17)	θ value	2.05525e-28 (rank : 9)
Query Neighborhood Hits	139	Target Neighborhood Hits	459	Shared Neighborhood Hits	48
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

FRM4B_HUMAN
NC score	0.763904 (rank : 18)	θ value	6.85773e-16 (rank : 36)
Query Neighborhood Hits	139	Target Neighborhood Hits	117	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
NC score	0.763790 (rank : 19)	θ value	1.80466e-16 (rank : 35)
Query Neighborhood Hits	139	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

MERL_HUMAN
NC score	0.755489 (rank : 20)	θ value	1.29031e-22 (rank : 31)
Query Neighborhood Hits	139	Target Neighborhood Hits	532	Shared Neighborhood Hits	54
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
NC score	0.755437 (rank : 21)	θ value	4.9032e-22 (rank : 33)
Query Neighborhood Hits	139	Target Neighborhood Hits	524	Shared Neighborhood Hits	52
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

FRM4A_MOUSE
NC score	0.752199 (rank : 22)	θ value	1.09485e-13 (rank : 38)
Query Neighborhood Hits	139	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_HUMAN
NC score	0.751439 (rank : 23)	θ value	8.38298e-14 (rank : 37)
Query Neighborhood Hits	139	Target Neighborhood Hits	110	Shared Neighborhood Hits	46
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FARP1_HUMAN
NC score	0.727054 (rank : 24)	θ value	1.47289e-26 (rank : 18)
Query Neighborhood Hits	139	Target Neighborhood Hits	241	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

EZRI_HUMAN
NC score	0.722339 (rank : 25)	θ value	1.62847e-25 (rank : 21)
Query Neighborhood Hits	139	Target Neighborhood Hits	663	Shared Neighborhood Hits	51
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
NC score	0.718511 (rank : 26)	θ value	4.28545e-26 (rank : 19)
Query Neighborhood Hits	139	Target Neighborhood Hits	693	Shared Neighborhood Hits	53
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

RADI_HUMAN
NC score	0.705896 (rank : 27)	θ value	5.06226e-27 (rank : 16)
Query Neighborhood Hits	139	Target Neighborhood Hits	741	Shared Neighborhood Hits	54
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

FARP2_HUMAN
NC score	0.703668 (rank : 28)	θ value	1.37858e-24 (rank : 25)
Query Neighborhood Hits	139	Target Neighborhood Hits	240	Shared Neighborhood Hits	44
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

RADI_MOUSE
NC score	0.701952 (rank : 29)	θ value	5.06226e-27 (rank : 17)
Query Neighborhood Hits	139	Target Neighborhood Hits	773	Shared Neighborhood Hits	53
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

FARP2_MOUSE
NC score	0.695217 (rank : 30)	θ value	5.23862e-24 (rank : 28)
Query Neighborhood Hits	139	Target Neighborhood Hits	209	Shared Neighborhood Hits	44
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MOES_HUMAN
NC score	0.664588 (rank : 31)	θ value	4.28545e-26 (rank : 20)
Query Neighborhood Hits	139	Target Neighborhood Hits	892	Shared Neighborhood Hits	56
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
NC score	0.656659 (rank : 32)	θ value	2.12685e-25 (rank : 24)
Query Neighborhood Hits	139	Target Neighborhood Hits	923	Shared Neighborhood Hits	57
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

PTN4_HUMAN
NC score	0.615641 (rank : 33)	θ value	4.42448e-31 (rank : 3)
Query Neighborhood Hits	139	Target Neighborhood Hits	303	Shared Neighborhood Hits	50
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

FRMD1_HUMAN
NC score	0.605742 (rank : 34)	θ value	3.41135e-07 (rank : 46)
Query Neighborhood Hits	139	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

PTN3_HUMAN
NC score	0.599208 (rank : 35)	θ value	3.74554e-30 (rank : 4)
Query Neighborhood Hits	139	Target Neighborhood Hits	258	Shared Neighborhood Hits	47
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN21_MOUSE
NC score	0.586197 (rank : 36)	θ value	1.86321e-21 (rank : 34)
Query Neighborhood Hits	139	Target Neighborhood Hits	155	Shared Neighborhood Hits	49
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN21_HUMAN
NC score	0.584940 (rank : 37)	θ value	2.87452e-22 (rank : 32)
Query Neighborhood Hits	139	Target Neighborhood Hits	143	Shared Neighborhood Hits	48
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN14_MOUSE
NC score	0.576784 (rank : 38)	θ value	1.80048e-24 (rank : 26)
Query Neighborhood Hits	139	Target Neighborhood Hits	142	Shared Neighborhood Hits	48
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN14_HUMAN
NC score	0.568921 (rank : 39)	θ value	5.79196e-23 (rank : 30)
Query Neighborhood Hits	139	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

FRMD6_MOUSE
NC score	0.567280 (rank : 40)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	139	Target Neighborhood Hits	63	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

FRMD6_HUMAN
NC score	0.561249 (rank : 41)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	139	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

PTN13_MOUSE
NC score	0.442291 (rank : 42)	θ value	6.64225e-11 (rank : 40)
Query Neighborhood Hits	139	Target Neighborhood Hits	426	Shared Neighborhood Hits	52
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN13_HUMAN
NC score	0.430246 (rank : 43)	θ value	8.11959e-09 (rank : 42)
Query Neighborhood Hits	139	Target Neighborhood Hits	471	Shared Neighborhood Hits	48
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

TLN1_HUMAN
NC score	0.379201 (rank : 44)	θ value	0.000602161 (rank : 58)
Query Neighborhood Hits	139	Target Neighborhood Hits	218	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
NC score	0.375017 (rank : 45)	θ value	0.00134147 (rank : 61)
Query Neighborhood Hits	139	Target Neighborhood Hits	213	Shared Neighborhood Hits	48
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TLN2_MOUSE
NC score	0.368884 (rank : 46)	θ value	0.00665767 (rank : 66)
Query Neighborhood Hits	139	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TLN2_HUMAN
NC score	0.363703 (rank : 47)	θ value	0.0113563 (rank : 68)
Query Neighborhood Hits	139	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

BIRC8_HUMAN
NC score	0.276066 (rank : 48)	θ value	8.11959e-09 (rank : 41)
Query Neighborhood Hits	139	Target Neighborhood Hits	121	Shared Neighborhood Hits	56
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC7_HUMAN
NC score	0.264540 (rank : 49)	θ value	5.26297e-08 (rank : 43)
Query Neighborhood Hits	139	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC3_MOUSE
NC score	0.263890 (rank : 50)	θ value	5.08577e-11 (rank : 39)
Query Neighborhood Hits	139	Target Neighborhood Hits	113	Shared Neighborhood Hits	58
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC3_HUMAN
NC score	0.255391 (rank : 51)	θ value	1.17247e-07 (rank : 44)
Query Neighborhood Hits	139	Target Neighborhood Hits	133	Shared Neighborhood Hits	58
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

RNF34_HUMAN
NC score	0.254620 (rank : 52)	θ value	3.19293e-05 (rank : 52)
Query Neighborhood Hits	139	Target Neighborhood Hits	153	Shared Neighborhood Hits	58
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

BIRC2_MOUSE
NC score	0.252590 (rank : 53)	θ value	3.41135e-07 (rank : 45)
Query Neighborhood Hits	139	Target Neighborhood Hits	137	Shared Neighborhood Hits	59
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

RNF34_MOUSE
NC score	0.252113 (rank : 54)	θ value	3.19293e-05 (rank : 53)
Query Neighborhood Hits	139	Target Neighborhood Hits	160	Shared Neighborhood Hits	57
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

BIRC2_HUMAN
NC score	0.252038 (rank : 55)	θ value	4.45536e-07 (rank : 47)
Query Neighborhood Hits	139	Target Neighborhood Hits	142	Shared Neighborhood Hits	57
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

RFFL_MOUSE
NC score	0.251798 (rank : 56)	θ value	2.44474e-05 (rank : 51)
Query Neighborhood Hits	139	Target Neighborhood Hits	145	Shared Neighborhood Hits	56
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
NC score	0.248285 (rank : 57)	θ value	2.44474e-05 (rank : 50)
Query Neighborhood Hits	139	Target Neighborhood Hits	175	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

BIRC4_HUMAN
NC score	0.241142 (rank : 58)	θ value	2.44474e-05 (rank : 48)
Query Neighborhood Hits	139	Target Neighborhood Hits	89	Shared Neighborhood Hits	50
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
NC score	0.239332 (rank : 59)	θ value	2.44474e-05 (rank : 49)
Query Neighborhood Hits	139	Target Neighborhood Hits	89	Shared Neighborhood Hits	49
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

RKHD1_HUMAN
NC score	0.218769 (rank : 60)	θ value	0.000461057 (rank : 57)
Query Neighborhood Hits	139	Target Neighborhood Hits	163	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RNF26_HUMAN
NC score	0.214147 (rank : 61)	θ value	0.0431538 (rank : 74)
Query Neighborhood Hits	139	Target Neighborhood Hits	95	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

CGRF1_HUMAN
NC score	0.210203 (rank : 62)	θ value	0.000786445 (rank : 59)
Query Neighborhood Hits	139	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_MOUSE
NC score	0.199408 (rank : 63)	θ value	0.00390308 (rank : 63)
Query Neighborhood Hits	139	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

NEURL_MOUSE
NC score	0.169579 (rank : 64)	θ value	0.0193708 (rank : 70)
Query Neighborhood Hits	139	Target Neighborhood Hits	106	Shared Neighborhood Hits	54
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
NC score	0.165023 (rank : 65)	θ value	0.0431538 (rank : 73)
Query Neighborhood Hits	139	Target Neighborhood Hits	114	Shared Neighborhood Hits	55
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

MGRN1_MOUSE
NC score	0.142484 (rank : 66)	θ value	0.21417 (rank : 85)
Query Neighborhood Hits	139	Target Neighborhood Hits	149	Shared Neighborhood Hits	54
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MGRN1_HUMAN
NC score	0.138087 (rank : 67)	θ value	0.21417 (rank : 84)
Query Neighborhood Hits	139	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

PEX10_HUMAN
NC score	0.125801 (rank : 68)	θ value	0.00175202 (rank : 62)
Query Neighborhood Hits	139	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

LRSM1_MOUSE
NC score	0.118765 (rank : 69)	θ value	0.00134147 (rank : 60)
Query Neighborhood Hits	139	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

CBLC_MOUSE
NC score	0.118498 (rank : 70)	θ value	0.0961366 (rank : 79)
Query Neighborhood Hits	139	Target Neighborhood Hits	186	Shared Neighborhood Hits	59
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

PTN2_MOUSE
NC score	0.116685 (rank : 71)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	139	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN1_MOUSE
NC score	0.116001 (rank : 72)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	139	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN1_HUMAN
NC score	0.115650 (rank : 73)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	139	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN18_HUMAN
NC score	0.115542 (rank : 74)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	139	Target Neighborhood Hits	73	Shared Neighborhood Hits	8
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN2_HUMAN
NC score	0.115466 (rank : 75)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	139	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

LRSM1_HUMAN
NC score	0.115349 (rank : 76)	θ value	0.00390308 (rank : 64)
Query Neighborhood Hits	139	Target Neighborhood Hits	1078	Shared Neighborhood Hits	61
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

CBLB_MOUSE
NC score	0.112470 (rank : 77)	θ value	0.0961366 (rank : 78)
Query Neighborhood Hits	139	Target Neighborhood Hits	277	Shared Neighborhood Hits	62
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBLB_HUMAN
NC score	0.112257 (rank : 78)	θ value	0.0961366 (rank : 77)
Query Neighborhood Hits	139	Target Neighborhood Hits	261	Shared Neighborhood Hits	62
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

PTN9_HUMAN
NC score	0.112250 (rank : 79)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	139	Target Neighborhood Hits	79	Shared Neighborhood Hits	8
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN18_MOUSE
NC score	0.112017 (rank : 80)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	139	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN9_MOUSE
NC score	0.111898 (rank : 81)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	139	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

CBLC_HUMAN
NC score	0.111400 (rank : 82)	θ value	0.365318 (rank : 89)
Query Neighborhood Hits	139	Target Neighborhood Hits	173	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

CBL_HUMAN
NC score	0.111302 (rank : 83)	θ value	0.125558 (rank : 81)
Query Neighborhood Hits	139	Target Neighborhood Hits	353	Shared Neighborhood Hits	65
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
NC score	0.108739 (rank : 84)	θ value	0.125558 (rank : 82)
Query Neighborhood Hits	139	Target Neighborhood Hits	426	Shared Neighborhood Hits	66
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

PTN22_HUMAN
NC score	0.108713 (rank : 85)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	139	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN7_MOUSE
NC score	0.108014 (rank : 86)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	139	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN22_MOUSE
NC score	0.107220 (rank : 87)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	139	Target Neighborhood Hits	179	Shared Neighborhood Hits	9
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN7_HUMAN
NC score	0.106841 (rank : 88)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	139	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN6_HUMAN
NC score	0.106775 (rank : 89)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	139	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
NC score	0.106756 (rank : 90)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	139	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN12_HUMAN
NC score	0.106555 (rank : 91)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	139	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
NC score	0.106242 (rank : 92)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	139	Target Neighborhood Hits	123	Shared Neighborhood Hits	8
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTPRO_HUMAN
NC score	0.104411 (rank : 93)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	139	Target Neighborhood Hits	139	Shared Neighborhood Hits	9
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRN_HUMAN
NC score	0.104079 (rank : 94)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	139	Target Neighborhood Hits	156	Shared Neighborhood Hits	11
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPR2_MOUSE
NC score	0.103726 (rank : 95)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	139	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPR2_HUMAN
NC score	0.103581 (rank : 96)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	139	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPRN_MOUSE
NC score	0.103553 (rank : 97)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	139	Target Neighborhood Hits	240	Shared Neighborhood Hits	9
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

KRIT1_HUMAN
NC score	0.103003 (rank : 98)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	139	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

PTPRR_MOUSE
NC score	0.102595 (rank : 99)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	139	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRR_HUMAN
NC score	0.102059 (rank : 100)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	139	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

CD45_MOUSE
NC score	0.101403 (rank : 101)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	139	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

PTPRJ_MOUSE
NC score	0.100592 (rank : 102)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	139	Target Neighborhood Hits	188	Shared Neighborhood Hits	10
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTN5_MOUSE
NC score	0.100564 (rank : 103)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	139	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_HUMAN
NC score	0.100464 (rank : 104)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	139	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN11_MOUSE
NC score	0.100067 (rank : 105)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	139	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.100066 (rank : 106)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	139	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTPRJ_HUMAN
NC score	0.099956 (rank : 107)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	139	Target Neighborhood Hits	207	Shared Neighborhood Hits	9
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRV_MOUSE
NC score	0.099571 (rank : 108)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	139	Target Neighborhood Hits	179	Shared Neighborhood Hits	9
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTN23_HUMAN
NC score	0.099129 (rank : 109)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	139	Target Neighborhood Hits	646	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTPRB_HUMAN
NC score	0.097874 (rank : 110)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	139	Target Neighborhood Hits	242	Shared Neighborhood Hits	9
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTN23_MOUSE
NC score	0.097714 (rank : 111)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	139	Target Neighborhood Hits	726	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

CD45_HUMAN
NC score	0.097552 (rank : 112)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	139	Target Neighborhood Hits	243	Shared Neighborhood Hits	10
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

KRIT1_MOUSE
NC score	0.096286 (rank : 113)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	139	Target Neighborhood Hits	258	Shared Neighborhood Hits	27
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

CA106_HUMAN
NC score	0.096013 (rank : 114)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	139	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CA106_MOUSE
NC score	0.094413 (rank : 115)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	139	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

MIB1_MOUSE
NC score	0.093618 (rank : 116)	θ value	5.44631e-05 (rank : 54)
Query Neighborhood Hits	139	Target Neighborhood Hits	471	Shared Neighborhood Hits	56
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

PTPRA_HUMAN
NC score	0.093525 (rank : 117)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	139	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
NC score	0.093481 (rank : 118)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	139	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRE_HUMAN
NC score	0.093475 (rank : 119)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	139	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
NC score	0.092912 (rank : 120)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	139	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

MIB1_HUMAN
NC score	0.092155 (rank : 121)	θ value	0.000121331 (rank : 55)
Query Neighborhood Hits	139	Target Neighborhood Hits	470	Shared Neighborhood Hits	56
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB2_HUMAN
NC score	0.088272 (rank : 122)	θ value	0.000461057 (rank : 56)
Query Neighborhood Hits	139	Target Neighborhood Hits	438	Shared Neighborhood Hits	45
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

MIB2_MOUSE
NC score	0.085844 (rank : 123)	θ value	0.0148317 (rank : 69)
Query Neighborhood Hits	139	Target Neighborhood Hits	409	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

UHRF2_MOUSE
NC score	0.084520 (rank : 124)	θ value	0.00869519 (rank : 67)
Query Neighborhood Hits	139	Target Neighborhood Hits	275	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

PTPRK_MOUSE
NC score	0.084277 (rank : 125)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	139	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

UHRF1_MOUSE
NC score	0.084056 (rank : 126)	θ value	0.00390308 (rank : 65)
Query Neighborhood Hits	139	Target Neighborhood Hits	278	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

PTPRZ_HUMAN
NC score	0.083727 (rank : 127)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	139	Target Neighborhood Hits	255	Shared Neighborhood Hits	9
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PTPRK_HUMAN
NC score	0.083588 (rank : 128)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	139	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRG_MOUSE
NC score	0.083331 (rank : 129)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	139	Target Neighborhood Hits	260	Shared Neighborhood Hits	11
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

BIRC5_MOUSE
NC score	0.083100 (rank : 130)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	139	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

PTPRG_HUMAN
NC score	0.083006 (rank : 131)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	139	Target Neighborhood Hits	231	Shared Neighborhood Hits	9
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

UHRF2_HUMAN
NC score	0.081299 (rank : 132)	θ value	0.0330416 (rank : 71)
Query Neighborhood Hits	139	Target Neighborhood Hits	269	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

PTPRT_HUMAN
NC score	0.080726 (rank : 133)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	139	Target Neighborhood Hits	217	Shared Neighborhood Hits	9
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
NC score	0.080683 (rank : 134)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	139	Target Neighborhood Hits	219	Shared Neighborhood Hits	9
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRM_MOUSE
NC score	0.078973 (rank : 135)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	139	Target Neighborhood Hits	238	Shared Neighborhood Hits	9
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRU_HUMAN
NC score	0.078743 (rank : 136)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	139	Target Neighborhood Hits	237	Shared Neighborhood Hits	9
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRM_HUMAN
NC score	0.078561 (rank : 137)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	139	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

BIRC5_HUMAN
NC score	0.077985 (rank : 138)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	139	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

RN168_HUMAN
NC score	0.077496 (rank : 139)	θ value	2.36792 (rank : 115)
Query Neighborhood Hits	139	Target Neighborhood Hits	370	Shared Neighborhood Hits	69
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RNF8_MOUSE
NC score	0.077358 (rank : 140)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	139	Target Neighborhood Hits	618	Shared Neighborhood Hits	75
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

ZC3H5_MOUSE
NC score	0.076665 (rank : 141)	θ value	0.0736092 (rank : 76)
Query Neighborhood Hits	139	Target Neighborhood Hits	136	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

ZC3H5_HUMAN
NC score	0.072629 (rank : 142)	θ value	0.21417 (rank : 87)
Query Neighborhood Hits	139	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

MDM4_HUMAN
NC score	0.072520 (rank : 143)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	139	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

BIRC1_HUMAN
NC score	0.069055 (rank : 144)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	139	Target Neighborhood Hits	61	Shared Neighborhood Hits	10
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

UHRF1_HUMAN
NC score	0.068722 (rank : 145)	θ value	0.47712 (rank : 94)
Query Neighborhood Hits	139	Target Neighborhood Hits	272	Shared Neighborhood Hits	40
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

BIR1E_MOUSE
NC score	0.068686 (rank : 146)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	139	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1B_MOUSE
NC score	0.068581 (rank : 147)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	139	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1F_MOUSE
NC score	0.068494 (rank : 148)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	139	Target Neighborhood Hits	88	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
NC score	0.068290 (rank : 149)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	139	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

MDM2_HUMAN
NC score	0.067795 (rank : 150)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	139	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

BIR1A_MOUSE
NC score	0.067369 (rank : 151)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	139	Target Neighborhood Hits	94	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

RNF8_HUMAN
NC score	0.066521 (rank : 152)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	139	Target Neighborhood Hits	622	Shared Neighborhood Hits	71
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

PTPRS_HUMAN
NC score	0.066095 (rank : 153)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	139	Target Neighborhood Hits	472	Shared Neighborhood Hits	10
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRD_HUMAN
NC score	0.064697 (rank : 154)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	139	Target Neighborhood Hits	485	Shared Neighborhood Hits	11
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

RN168_MOUSE
NC score	0.063656 (rank : 155)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	139	Target Neighborhood Hits	440	Shared Neighborhood Hits	65
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

PTPRF_HUMAN
NC score	0.062823 (rank : 156)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	139	Target Neighborhood Hits	489	Shared Neighborhood Hits	9
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

TRI37_MOUSE
NC score	0.062768 (rank : 157)	θ value	0.365318 (rank : 91)
Query Neighborhood Hits	139	Target Neighborhood Hits	316	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

PTPRD_MOUSE
NC score	0.062177 (rank : 158)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	139	Target Neighborhood Hits	491	Shared Neighborhood Hits	10
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

TRI35_MOUSE
NC score	0.062162 (rank : 159)	θ value	0.21417 (rank : 86)
Query Neighborhood Hits	139	Target Neighborhood Hits	465	Shared Neighborhood Hits	70
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRI37_HUMAN
NC score	0.061842 (rank : 160)	θ value	0.365318 (rank : 90)
Query Neighborhood Hits	139	Target Neighborhood Hits	307	Shared Neighborhood Hits	44
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

RN169_HUMAN
NC score	0.060752 (rank : 161)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	139	Target Neighborhood Hits	203	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

MYO7A_MOUSE
NC score	0.060303 (rank : 162)	θ value	0.125558 (rank : 83)
Query Neighborhood Hits	139	Target Neighborhood Hits	235	Shared Neighborhood Hits	26
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO7A_HUMAN
NC score	0.059973 (rank : 163)	θ value	0.0961366 (rank : 80)
Query Neighborhood Hits	139	Target Neighborhood Hits	209	Shared Neighborhood Hits	28
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

RN185_HUMAN
NC score	0.059906 (rank : 164)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	139	Target Neighborhood Hits	213	Shared Neighborhood Hits	57
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
NC score	0.059327 (rank : 165)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	139	Target Neighborhood Hits	211	Shared Neighborhood Hits	57
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

TRI35_HUMAN
NC score	0.059178 (rank : 166)	θ value	0.0736092 (rank : 75)
Query Neighborhood Hits	139	Target Neighborhood Hits	382	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

TRI26_MOUSE
NC score	0.057196 (rank : 167)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	139	Target Neighborhood Hits	339	Shared Neighborhood Hits	71
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI32_MOUSE
NC score	0.056872 (rank : 168)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	139	Target Neighborhood Hits	271	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI26_HUMAN
NC score	0.056435 (rank : 169)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	139	Target Neighborhood Hits	335	Shared Neighborhood Hits	71
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI31_HUMAN
NC score	0.056274 (rank : 170)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	139	Target Neighborhood Hits	299	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

FGD5_HUMAN
NC score	0.056116 (rank : 171)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	139	Target Neighborhood Hits	235	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

HIP1_HUMAN
NC score	0.055807 (rank : 172)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	139	Target Neighborhood Hits	1016	Shared Neighborhood Hits	27
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

TRI12_MOUSE
NC score	0.054903 (rank : 173)	θ value	0.62314 (rank : 97)
Query Neighborhood Hits	139	Target Neighborhood Hits	387	Shared Neighborhood Hits	59
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

RN123_MOUSE
NC score	0.054269 (rank : 174)	θ value	3.0926 (rank : 118)
Query Neighborhood Hits	139	Target Neighborhood Hits	174	Shared Neighborhood Hits	45
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

RO52_HUMAN
NC score	0.054114 (rank : 175)	θ value	0.62314 (rank : 96)
Query Neighborhood Hits	139	Target Neighborhood Hits	419	Shared Neighborhood Hits	71
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

TRIM2_HUMAN
NC score	0.054077 (rank : 176)	θ value	0.47712 (rank : 93)
Query Neighborhood Hits	139	Target Neighborhood Hits	330	Shared Neighborhood Hits	56
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRI56_HUMAN
NC score	0.053415 (rank : 177)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	139	Target Neighborhood Hits	339	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

LNX2_HUMAN
NC score	0.053337 (rank : 178)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	139	Target Neighborhood Hits	389	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

TRIM2_MOUSE
NC score	0.053179 (rank : 179)	θ value	0.62314 (rank : 98)
Query Neighborhood Hits	139	Target Neighborhood Hits	331	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

FGD5_MOUSE
NC score	0.053176 (rank : 180)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	139	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

RNF5_HUMAN
NC score	0.052990 (rank : 181)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	139	Target Neighborhood Hits	206	Shared Neighborhood Hits	62
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

FGD6_HUMAN
NC score	0.052951 (rank : 182)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	139	Target Neighborhood Hits	237	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
NC score	0.052548 (rank : 183)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	139	Target Neighborhood Hits	282	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

TRI56_MOUSE
NC score	0.052244 (rank : 184)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	139	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

HIP1R_HUMAN
NC score	0.052214 (rank : 185)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	139	Target Neighborhood Hits	809	Shared Neighborhood Hits	19
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

RNF5_MOUSE
NC score	0.052210 (rank : 186)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	139	Target Neighborhood Hits	206	Shared Neighborhood Hits	62
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

RN123_HUMAN
NC score	0.051267 (rank : 187)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	139	Target Neighborhood Hits	175	Shared Neighborhood Hits	43
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

FGD4_MOUSE
NC score	0.051153 (rank : 188)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	139	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

CCD50_HUMAN
NC score	0.050982 (rank : 189)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	139	Target Neighborhood Hits	237	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IVM0, Q86VH7	Gene names	CCDC50, C3orf6
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

TRI32_HUMAN
NC score	0.050869 (rank : 190)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	139	Target Neighborhood Hits	264	Shared Neighborhood Hits	46
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

FGD4_HUMAN
NC score	0.050863 (rank : 191)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	139	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

TRI50_MOUSE
NC score	0.049677 (rank : 192)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	139	Target Neighborhood Hits	326	Shared Neighborhood Hits	73
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

RO52_MOUSE
NC score	0.048675 (rank : 193)	θ value	3.0926 (rank : 119)
Query Neighborhood Hits	139	Target Neighborhood Hits	360	Shared Neighborhood Hits	68
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

LNX2_MOUSE
NC score	0.048614 (rank : 194)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	139	Target Neighborhood Hits	407	Shared Neighborhood Hits	48
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

PML_HUMAN
NC score	0.047283 (rank : 195)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	139	Target Neighborhood Hits	248	Shared Neighborhood Hits	42
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

TRI50_HUMAN
NC score	0.046847 (rank : 196)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	139	Target Neighborhood Hits	294	Shared Neighborhood Hits	68
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

MYO10_HUMAN
NC score	0.046020 (rank : 197)	θ value	0.0431538 (rank : 72)
Query Neighborhood Hits	139	Target Neighborhood Hits	920	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

TRI27_MOUSE
NC score	0.042998 (rank : 198)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	139	Target Neighborhood Hits	261	Shared Neighborhood Hits	65
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

PML_MOUSE
NC score	0.042628 (rank : 199)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	139	Target Neighborhood Hits	246	Shared Neighborhood Hits	43
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

BRE1B_MOUSE
NC score	0.042027 (rank : 200)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	139	Target Neighborhood Hits	970	Shared Neighborhood Hits	53
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

BRE1B_HUMAN
NC score	0.040162 (rank : 201)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	139	Target Neighborhood Hits	1040	Shared Neighborhood Hits	53
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

TRI27_HUMAN
NC score	0.038380 (rank : 202)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	139	Target Neighborhood Hits	273	Shared Neighborhood Hits	64
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

LNX1_HUMAN
NC score	0.037487 (rank : 203)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	139	Target Neighborhood Hits	379	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

RFWD2_MOUSE
NC score	0.031530 (rank : 204)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	139	Target Neighborhood Hits	535	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

TRI42_HUMAN
NC score	0.031305 (rank : 205)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	139	Target Neighborhood Hits	283	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

RFWD2_HUMAN
NC score	0.030001 (rank : 206)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	139	Target Neighborhood Hits	518	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

HMDH_MOUSE
NC score	0.029410 (rank : 207)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	139	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

TRI42_MOUSE
NC score	0.029329 (rank : 208)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	139	Target Neighborhood Hits	316	Shared Neighborhood Hits	41
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRAF7_MOUSE
NC score	0.025974 (rank : 209)	θ value	0.813845 (rank : 99)
Query Neighborhood Hits	139	Target Neighborhood Hits	470	Shared Neighborhood Hits	45
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TRAF7_HUMAN
NC score	0.025840 (rank : 210)	θ value	1.06291 (rank : 101)
Query Neighborhood Hits	139	Target Neighborhood Hits	482	Shared Neighborhood Hits	45
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

CNOT4_HUMAN
NC score	0.021294 (rank : 211)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	139	Target Neighborhood Hits	207	Shared Neighborhood Hits	18
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CNOT4_MOUSE
NC score	0.020354 (rank : 212)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	139	Target Neighborhood Hits	277	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

RNF24_MOUSE
NC score	0.019133 (rank : 213)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	139	Target Neighborhood Hits	124	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BGI1	Gene names	Rnf24
Domain Architecture	No domain graphic available
Description	RING finger protein 24.

HMDH_HUMAN
NC score	0.017041 (rank : 214)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	139	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

NALP6_MOUSE
NC score	0.014802 (rank : 215)	θ value	0.279714 (rank : 88)
Query Neighborhood Hits	139	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

MUC5B_HUMAN
NC score	0.012742 (rank : 216)	θ value	0.47712 (rank : 92)
Query Neighborhood Hits	139	Target Neighborhood Hits	1020	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

K2002_MOUSE
NC score	0.010149 (rank : 217)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	139	Target Neighborhood Hits	267	Shared Neighborhood Hits	3
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

NALP6_HUMAN
NC score	0.009437 (rank : 218)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	139	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

FRAS1_MOUSE
NC score	0.005377 (rank : 219)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	139	Target Neighborhood Hits	747	Shared Neighborhood Hits	8
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

TITIN_HUMAN
NC score	0.003614 (rank : 220)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	139	Target Neighborhood Hits	2923	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

SPI2_HUMAN
NC score	0.000006 (rank : 221)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	139	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	O75830	Gene names	SERPINI2, MEPI, PI14
Domain Architecture
Description	Serpin I2 precursor (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Protease inhibitor 14) (TSA2004).

ZN142_HUMAN
NC score	-0.004873 (rank : 222)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	139	Target Neighborhood Hits	1007	Shared Neighborhood Hits	4
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ZN646_HUMAN
NC score	-0.006057 (rank : 223)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	139	Target Neighborhood Hits	813	Shared Neighborhood Hits	3
SwissProt Accessions	O15015	Gene names	ZNF646, KIAA0296
Domain Architecture	No domain graphic available
Description	Zinc finger protein 646.