Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : HMDH_HUMAN

For an explanation of this page, click here

HMDH_HUMAN
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HMDH_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
θ value	0 (rank : 2)	NC score	0.998743 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

SCAP_HUMAN
θ value	7.59969e-07 (rank : 3)	NC score	0.195804 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	368	Shared Neighborhood Hits	5
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

NPC1_MOUSE
θ value	4.92598e-06 (rank : 4)	NC score	0.211238 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_HUMAN
θ value	1.43324e-05 (rank : 5)	NC score	0.204755 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

CELR1_HUMAN
θ value	1.06291 (rank : 6)	NC score	0.006994 (rank : 14)
Query Neighborhood Hits	13	Target Neighborhood Hits	613	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NYQ6, O95722, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526	Gene names	CELSR1, CDHF9, FMI2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).

CAZA3_HUMAN
θ value	3.0926 (rank : 7)	NC score	0.042691 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q96KX2, Q969J0	Gene names	CAPZA3, CAPAA3, GSG3
Domain Architecture
Description	F-actin capping protein alpha-3 subunit (CapZ alpha-3) (CP-alpha-3) (Germ cell-specific protein 3).

AFF2_MOUSE
θ value	4.03905 (rank : 8)	NC score	0.016730 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	225	Shared Neighborhood Hits	2
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

CAZA3_MOUSE
θ value	5.27518 (rank : 9)	NC score	0.036545 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P70190, Q9D4N3	Gene names	Capza3, Cappa3, Gsg3
Domain Architecture
Description	F-actin capping protein alpha-3 subunit (CapZ alpha-3) (Germ cell- specific protein 3).

RN5A_MOUSE
θ value	5.27518 (rank : 10)	NC score	0.007752 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	899	Shared Neighborhood Hits	3
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

CV019_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.018978 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q13769, O60839, Q9UPZ5	Gene names	C22orf19, KIAA0983
Domain Architecture	No domain graphic available
Description	Protein C22orf19 (NF2/meningioma region protein pK1.3) (Placental protein 39.2).

GBRG3_MOUSE
θ value	8.99809 (rank : 12)	NC score	0.003858 (rank : 15)
Query Neighborhood Hits	13	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P27681	Gene names	Gabrg3
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit gamma-3 precursor (GABA(A) receptor subunit gamma-3).

MYLIP_MOUSE
θ value	8.99809 (rank : 13)	NC score	0.017041 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NPCL1_HUMAN
θ value	θ > 10 (rank : 14)	NC score	0.091641 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_MOUSE
θ value	θ > 10 (rank : 15)	NC score	0.092076 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

Hits sorted by NC score

HMDH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
NC score	0.998743 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

NPC1_MOUSE
NC score	0.211238 (rank : 3)	θ value	4.92598e-06 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_HUMAN
NC score	0.204755 (rank : 4)	θ value	1.43324e-05 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

SCAP_HUMAN
NC score	0.195804 (rank : 5)	θ value	7.59969e-07 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	368	Shared Neighborhood Hits	5
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

NPCL1_MOUSE
NC score	0.092076 (rank : 6)	θ value	θ > 10 (rank : 15)
Query Neighborhood Hits	13	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_HUMAN
NC score	0.091641 (rank : 7)	θ value	θ > 10 (rank : 14)
Query Neighborhood Hits	13	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

CAZA3_HUMAN
NC score	0.042691 (rank : 8)	θ value	3.0926 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q96KX2, Q969J0	Gene names	CAPZA3, CAPAA3, GSG3
Domain Architecture
Description	F-actin capping protein alpha-3 subunit (CapZ alpha-3) (CP-alpha-3) (Germ cell-specific protein 3).

CAZA3_MOUSE
NC score	0.036545 (rank : 9)	θ value	5.27518 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P70190, Q9D4N3	Gene names	Capza3, Cappa3, Gsg3
Domain Architecture
Description	F-actin capping protein alpha-3 subunit (CapZ alpha-3) (Germ cell- specific protein 3).

CV019_HUMAN
NC score	0.018978 (rank : 10)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q13769, O60839, Q9UPZ5	Gene names	C22orf19, KIAA0983
Domain Architecture	No domain graphic available
Description	Protein C22orf19 (NF2/meningioma region protein pK1.3) (Placental protein 39.2).

MYLIP_MOUSE
NC score	0.017041 (rank : 11)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

AFF2_MOUSE
NC score	0.016730 (rank : 12)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	225	Shared Neighborhood Hits	2
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

RN5A_MOUSE
NC score	0.007752 (rank : 13)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	899	Shared Neighborhood Hits	3
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

CELR1_HUMAN
NC score	0.006994 (rank : 14)	θ value	1.06291 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	613	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NYQ6, O95722, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526	Gene names	CELSR1, CDHF9, FMI2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).

GBRG3_MOUSE
NC score	0.003858 (rank : 15)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P27681	Gene names	Gabrg3
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit gamma-3 precursor (GABA(A) receptor subunit gamma-3).