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Network neighborhood for query Sequence : CGRF1_MOUSE

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CGRF1_MOUSE
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CGRF1_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_HUMAN
θ value	5.94893e-161 (rank : 2)	NC score	0.992282 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

RNF26_HUMAN
θ value	1.29631e-06 (rank : 3)	NC score	0.505775 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	95	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

MGRN1_HUMAN
θ value	3.19293e-05 (rank : 4)	NC score	0.383772 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	192	Shared Neighborhood Hits	43
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MGRN1_MOUSE
θ value	4.1701e-05 (rank : 5)	NC score	0.376821 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	149	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

LRSM1_HUMAN
θ value	0.000121331 (rank : 6)	NC score	0.176281 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	1078	Shared Neighborhood Hits	35
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

LRSM1_MOUSE
θ value	0.000158464 (rank : 7)	NC score	0.196454 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

RNF34_HUMAN
θ value	0.00020696 (rank : 8)	NC score	0.417909 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	153	Shared Neighborhood Hits	35
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	0.00020696 (rank : 9)	NC score	0.419487 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	160	Shared Neighborhood Hits	38
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

BIRC3_HUMAN
θ value	0.00035302 (rank : 10)	NC score	0.327659 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	133	Shared Neighborhood Hits	38
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC2_HUMAN
θ value	0.000461057 (rank : 11)	NC score	0.330223 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	142	Shared Neighborhood Hits	39
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

RFFL_HUMAN
θ value	0.000461057 (rank : 12)	NC score	0.399181 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	0.000461057 (rank : 13)	NC score	0.405447 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	145	Shared Neighborhood Hits	32
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

MIB1_HUMAN
θ value	0.000602161 (rank : 14)	NC score	0.154823 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	470	Shared Neighborhood Hits	36
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	0.000602161 (rank : 15)	NC score	0.154439 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	471	Shared Neighborhood Hits	36
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

BIRC2_MOUSE
θ value	0.000786445 (rank : 16)	NC score	0.325843 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	137	Shared Neighborhood Hits	38
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

MYLIP_HUMAN
θ value	0.00134147 (rank : 17)	NC score	0.220542 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

BIRC3_MOUSE
θ value	0.00175202 (rank : 18)	NC score	0.324999 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	113	Shared Neighborhood Hits	34
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

MYLIP_MOUSE
θ value	0.00390308 (rank : 19)	NC score	0.199408 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	139	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NEURL_MOUSE
θ value	0.00665767 (rank : 20)	NC score	0.321994 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	106	Shared Neighborhood Hits	35
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
θ value	0.0148317 (rank : 21)	NC score	0.318354 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

RKHD1_HUMAN
θ value	0.0193708 (rank : 22)	NC score	0.319017 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	163	Shared Neighborhood Hits	35
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

MIB2_HUMAN
θ value	0.0431538 (rank : 23)	NC score	0.135440 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	438	Shared Neighborhood Hits	37
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

BIRC4_HUMAN
θ value	0.0563607 (rank : 24)	NC score	0.288965 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	89	Shared Neighborhood Hits	35
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	0.0563607 (rank : 25)	NC score	0.286823 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	89	Shared Neighborhood Hits	34
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

MIB2_MOUSE
θ value	0.0563607 (rank : 26)	NC score	0.132574 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	409	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

BIRC8_HUMAN
θ value	0.0961366 (rank : 27)	NC score	0.327702 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	121	Shared Neighborhood Hits	37
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

RN146_HUMAN
θ value	0.0961366 (rank : 28)	NC score	0.151551 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

RN146_MOUSE
θ value	0.0961366 (rank : 29)	NC score	0.150585 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CZW6, Q3TF93	Gene names	Rnf146
Domain Architecture	No domain graphic available
Description	RING finger protein 146.

BIRC7_HUMAN
θ value	0.125558 (rank : 30)	NC score	0.306456 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

RNF8_MOUSE
θ value	0.47712 (rank : 31)	NC score	0.116963 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	618	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

ZC3H5_HUMAN
θ value	0.813845 (rank : 32)	NC score	0.115971 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	134	Shared Neighborhood Hits	22
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

RBBP6_HUMAN
θ value	1.06291 (rank : 33)	NC score	0.048814 (rank : 65)
Query Neighborhood Hits	47	Target Neighborhood Hits	1135	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RBBP6_MOUSE
θ value	1.06291 (rank : 34)	NC score	0.054177 (rank : 57)
Query Neighborhood Hits	47	Target Neighborhood Hits	1014	Shared Neighborhood Hits	20
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

ZC3H5_MOUSE
θ value	1.06291 (rank : 35)	NC score	0.115216 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	136	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

R113A_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.067035 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	177	Shared Neighborhood Hits	15
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

TRI65_MOUSE
θ value	1.81305 (rank : 37)	NC score	0.055573 (rank : 56)
Query Neighborhood Hits	47	Target Neighborhood Hits	340	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

R113B_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.061578 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	165	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZP6, Q8WWF9, Q96QY9	Gene names	RNF113B, RNF161, ZNF183L1
Domain Architecture
Description	RING finger protein 113B (Zinc finger protein 183-like 1).

RNF8_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.104353 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	622	Shared Neighborhood Hits	39
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

TRI65_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.038633 (rank : 66)
Query Neighborhood Hits	47	Target Neighborhood Hits	330	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

MDM2_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.096033 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	92	Shared Neighborhood Hits	24
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

TRI42_MOUSE
θ value	6.88961 (rank : 42)	NC score	0.027547 (rank : 67)
Query Neighborhood Hits	47	Target Neighborhood Hits	316	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

MDM2_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.082615 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

TRI18_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.024070 (rank : 69)
Query Neighborhood Hits	47	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TRI18_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.025928 (rank : 68)
Query Neighborhood Hits	47	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TTLL7_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.011121 (rank : 70)
Query Neighborhood Hits	47	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

WDR24_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.009390 (rank : 71)
Query Neighborhood Hits	47	Target Neighborhood Hits	247	Shared Neighborhood Hits	2
SwissProt Accessions	Q96S15, Q96GC7, Q9H0B7	Gene names	WDR24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

BIR1A_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.074440 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1B_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.075784 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1E_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.076435 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.076192 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.076077 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIRC1_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.076999 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	61	Shared Neighborhood Hits	8
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIRC5_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.084353 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.090251 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC6_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.056264 (rank : 55)
Query Neighborhood Hits	47	Target Neighborhood Hits	161	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

CBLB_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.053216 (rank : 60)
Query Neighborhood Hits	47	Target Neighborhood Hits	261	Shared Neighborhood Hits	29
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBLB_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.053952 (rank : 58)
Query Neighborhood Hits	47	Target Neighborhood Hits	277	Shared Neighborhood Hits	29
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBLC_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.052774 (rank : 61)
Query Neighborhood Hits	47	Target Neighborhood Hits	173	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

CBLC_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.056552 (rank : 54)
Query Neighborhood Hits	47	Target Neighborhood Hits	186	Shared Neighborhood Hits	28
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

CBL_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.053385 (rank : 59)
Query Neighborhood Hits	47	Target Neighborhood Hits	353	Shared Neighborhood Hits	27
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.052328 (rank : 62)
Query Neighborhood Hits	47	Target Neighborhood Hits	426	Shared Neighborhood Hits	29
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

MDM4_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.092538 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

PEX10_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.072950 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	255	Shared Neighborhood Hits	29
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

RN141_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.060264 (rank : 52)
Query Neighborhood Hits	47	Target Neighborhood Hits	199	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.059823 (rank : 53)
Query Neighborhood Hits	47	Target Neighborhood Hits	200	Shared Neighborhood Hits	16
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN168_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.065695 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	370	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN168_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.051722 (rank : 63)
Query Neighborhood Hits	47	Target Neighborhood Hits	440	Shared Neighborhood Hits	29
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN185_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.061898 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	213	Shared Neighborhood Hits	30
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.060989 (rank : 51)
Query Neighborhood Hits	47	Target Neighborhood Hits	211	Shared Neighborhood Hits	30
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

TRI26_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.051015 (rank : 64)
Query Neighborhood Hits	47	Target Neighborhood Hits	339	Shared Neighborhood Hits	37
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

Hits sorted by NC score

CGRF1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_HUMAN
NC score	0.992282 (rank : 2)	θ value	5.94893e-161 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

RNF26_HUMAN
NC score	0.505775 (rank : 3)	θ value	1.29631e-06 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	95	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

RNF34_MOUSE
NC score	0.419487 (rank : 4)	θ value	0.00020696 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	160	Shared Neighborhood Hits	38
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.417909 (rank : 5)	θ value	0.00020696 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	153	Shared Neighborhood Hits	35
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RFFL_MOUSE
NC score	0.405447 (rank : 6)	θ value	0.000461057 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	145	Shared Neighborhood Hits	32
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
NC score	0.399181 (rank : 7)	θ value	0.000461057 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

MGRN1_HUMAN
NC score	0.383772 (rank : 8)	θ value	3.19293e-05 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	192	Shared Neighborhood Hits	43
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MGRN1_MOUSE
NC score	0.376821 (rank : 9)	θ value	4.1701e-05 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	149	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

BIRC2_HUMAN
NC score	0.330223 (rank : 10)	θ value	0.000461057 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	142	Shared Neighborhood Hits	39
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC8_HUMAN
NC score	0.327702 (rank : 11)	θ value	0.0961366 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	121	Shared Neighborhood Hits	37
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC3_HUMAN
NC score	0.327659 (rank : 12)	θ value	0.00035302 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	133	Shared Neighborhood Hits	38
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC2_MOUSE
NC score	0.325843 (rank : 13)	θ value	0.000786445 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	137	Shared Neighborhood Hits	38
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_MOUSE
NC score	0.324999 (rank : 14)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	113	Shared Neighborhood Hits	34
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

NEURL_MOUSE
NC score	0.321994 (rank : 15)	θ value	0.00665767 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	106	Shared Neighborhood Hits	35
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

RKHD1_HUMAN
NC score	0.319017 (rank : 16)	θ value	0.0193708 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	163	Shared Neighborhood Hits	35
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

NEUL1_HUMAN
NC score	0.318354 (rank : 17)	θ value	0.0148317 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

BIRC7_HUMAN
NC score	0.306456 (rank : 18)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC4_HUMAN
NC score	0.288965 (rank : 19)	θ value	0.0563607 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	89	Shared Neighborhood Hits	35
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
NC score	0.286823 (rank : 20)	θ value	0.0563607 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	89	Shared Neighborhood Hits	34
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

MYLIP_HUMAN
NC score	0.220542 (rank : 21)	θ value	0.00134147 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
NC score	0.199408 (rank : 22)	θ value	0.00390308 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	139	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

LRSM1_MOUSE
NC score	0.196454 (rank : 23)	θ value	0.000158464 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

LRSM1_HUMAN
NC score	0.176281 (rank : 24)	θ value	0.000121331 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	1078	Shared Neighborhood Hits	35
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MIB1_HUMAN
NC score	0.154823 (rank : 25)	θ value	0.000602161 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	470	Shared Neighborhood Hits	36
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
NC score	0.154439 (rank : 26)	θ value	0.000602161 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	471	Shared Neighborhood Hits	36
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

RN146_HUMAN
NC score	0.151551 (rank : 27)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

RN146_MOUSE
NC score	0.150585 (rank : 28)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CZW6, Q3TF93	Gene names	Rnf146
Domain Architecture	No domain graphic available
Description	RING finger protein 146.

MIB2_HUMAN
NC score	0.135440 (rank : 29)	θ value	0.0431538 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	438	Shared Neighborhood Hits	37
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

MIB2_MOUSE
NC score	0.132574 (rank : 30)	θ value	0.0563607 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	409	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

RNF8_MOUSE
NC score	0.116963 (rank : 31)	θ value	0.47712 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	618	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

ZC3H5_HUMAN
NC score	0.115971 (rank : 32)	θ value	0.813845 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	134	Shared Neighborhood Hits	22
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

ZC3H5_MOUSE
NC score	0.115216 (rank : 33)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	136	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

RNF8_HUMAN
NC score	0.104353 (rank : 34)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	622	Shared Neighborhood Hits	39
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

MDM2_HUMAN
NC score	0.096033 (rank : 35)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	92	Shared Neighborhood Hits	24
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MDM4_HUMAN
NC score	0.092538 (rank : 36)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	47	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

BIRC5_MOUSE
NC score	0.090251 (rank : 37)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	47	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC5_HUMAN
NC score	0.084353 (rank : 38)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	47	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

MDM2_MOUSE
NC score	0.082615 (rank : 39)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

BIRC1_HUMAN
NC score	0.076999 (rank : 40)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	47	Target Neighborhood Hits	61	Shared Neighborhood Hits	8
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1E_MOUSE
NC score	0.076435 (rank : 41)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
NC score	0.076192 (rank : 42)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	47	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
NC score	0.076077 (rank : 43)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	47	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.075784 (rank : 44)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1A_MOUSE
NC score	0.074440 (rank : 45)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

PEX10_HUMAN
NC score	0.072950 (rank : 46)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	47	Target Neighborhood Hits	255	Shared Neighborhood Hits	29
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

R113A_HUMAN
NC score	0.067035 (rank : 47)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	177	Shared Neighborhood Hits	15
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

RN168_HUMAN
NC score	0.065695 (rank : 48)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	47	Target Neighborhood Hits	370	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN185_HUMAN
NC score	0.061898 (rank : 49)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	47	Target Neighborhood Hits	213	Shared Neighborhood Hits	30
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

R113B_HUMAN
NC score	0.061578 (rank : 50)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	165	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZP6, Q8WWF9, Q96QY9	Gene names	RNF113B, RNF161, ZNF183L1
Domain Architecture
Description	RING finger protein 113B (Zinc finger protein 183-like 1).

RN185_MOUSE
NC score	0.060989 (rank : 51)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	47	Target Neighborhood Hits	211	Shared Neighborhood Hits	30
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN141_HUMAN
NC score	0.060264 (rank : 52)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	47	Target Neighborhood Hits	199	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_MOUSE
NC score	0.059823 (rank : 53)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	47	Target Neighborhood Hits	200	Shared Neighborhood Hits	16
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

CBLC_MOUSE
NC score	0.056552 (rank : 54)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	47	Target Neighborhood Hits	186	Shared Neighborhood Hits	28
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

BIRC6_HUMAN
NC score	0.056264 (rank : 55)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	47	Target Neighborhood Hits	161	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

TRI65_MOUSE
NC score	0.055573 (rank : 56)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	340	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

RBBP6_MOUSE
NC score	0.054177 (rank : 57)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	1014	Shared Neighborhood Hits	20
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

CBLB_MOUSE
NC score	0.053952 (rank : 58)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	47	Target Neighborhood Hits	277	Shared Neighborhood Hits	29
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBL_HUMAN
NC score	0.053385 (rank : 59)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	47	Target Neighborhood Hits	353	Shared Neighborhood Hits	27
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBLB_HUMAN
NC score	0.053216 (rank : 60)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	47	Target Neighborhood Hits	261	Shared Neighborhood Hits	29
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBLC_HUMAN
NC score	0.052774 (rank : 61)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	47	Target Neighborhood Hits	173	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

CBL_MOUSE
NC score	0.052328 (rank : 62)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	47	Target Neighborhood Hits	426	Shared Neighborhood Hits	29
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

RN168_MOUSE
NC score	0.051722 (rank : 63)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	47	Target Neighborhood Hits	440	Shared Neighborhood Hits	29
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI26_MOUSE
NC score	0.051015 (rank : 64)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	47	Target Neighborhood Hits	339	Shared Neighborhood Hits	37
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

RBBP6_HUMAN
NC score	0.048814 (rank : 65)	θ value	1.06291 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	1135	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

TRI65_HUMAN
NC score	0.038633 (rank : 66)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	330	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI42_MOUSE
NC score	0.027547 (rank : 67)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	316	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI18_MOUSE
NC score	0.025928 (rank : 68)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TRI18_HUMAN
NC score	0.024070 (rank : 69)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TTLL7_HUMAN
NC score	0.011121 (rank : 70)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

WDR24_HUMAN
NC score	0.009390 (rank : 71)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	247	Shared Neighborhood Hits	2
SwissProt Accessions	Q96S15, Q96GC7, Q9H0B7	Gene names	WDR24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.