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Network neighborhood for query Sequence : MYLIP_HUMAN

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MYLIP_HUMAN
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MYLIP_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	162	Target Neighborhood Hits	162	Shared Neighborhood Hits	162
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	0 (rank : 2)	NC score	0.994821 (rank : 2)
Query Neighborhood Hits	162	Target Neighborhood Hits	139	Shared Neighborhood Hits	128
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

PTN4_HUMAN
θ value	2.19584e-30 (rank : 3)	NC score	0.603077 (rank : 33)
Query Neighborhood Hits	162	Target Neighborhood Hits	303	Shared Neighborhood Hits	49
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN3_HUMAN
θ value	1.4233e-29 (rank : 4)	NC score	0.587294 (rank : 35)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	48
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

E41L5_HUMAN
θ value	2.42779e-29 (rank : 5)	NC score	0.859683 (rank : 3)
Query Neighborhood Hits	162	Target Neighborhood Hits	76	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
θ value	4.14116e-29 (rank : 6)	NC score	0.858310 (rank : 4)
Query Neighborhood Hits	162	Target Neighborhood Hits	59	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

E41LB_HUMAN
θ value	1.2049e-28 (rank : 7)	NC score	0.852527 (rank : 7)
Query Neighborhood Hits	162	Target Neighborhood Hits	79	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41L2_HUMAN
θ value	1.57365e-28 (rank : 8)	NC score	0.831368 (rank : 16)
Query Neighborhood Hits	162	Target Neighborhood Hits	287	Shared Neighborhood Hits	47
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

41_HUMAN
θ value	3.50572e-28 (rank : 9)	NC score	0.840837 (rank : 12)
Query Neighborhood Hits	162	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	3.50572e-28 (rank : 10)	NC score	0.838008 (rank : 14)
Query Neighborhood Hits	162	Target Neighborhood Hits	184	Shared Neighborhood Hits	45
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L1_HUMAN
θ value	1.02001e-27 (rank : 11)	NC score	0.838209 (rank : 13)
Query Neighborhood Hits	162	Target Neighborhood Hits	180	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L3_MOUSE
θ value	1.02001e-27 (rank : 12)	NC score	0.833915 (rank : 15)
Query Neighborhood Hits	162	Target Neighborhood Hits	250	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L2_MOUSE
θ value	1.33217e-27 (rank : 13)	NC score	0.812270 (rank : 17)
Query Neighborhood Hits	162	Target Neighborhood Hits	459	Shared Neighborhood Hits	46
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	1.73987e-27 (rank : 14)	NC score	0.846151 (rank : 10)
Query Neighborhood Hits	162	Target Neighborhood Hits	113	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L1_MOUSE
θ value	2.27234e-27 (rank : 15)	NC score	0.842679 (rank : 11)
Query Neighborhood Hits	162	Target Neighborhood Hits	106	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

FARP1_HUMAN
θ value	2.96777e-27 (rank : 16)	NC score	0.715513 (rank : 24)
Query Neighborhood Hits	162	Target Neighborhood Hits	241	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

RADI_HUMAN
θ value	2.96777e-27 (rank : 17)	NC score	0.692467 (rank : 28)
Query Neighborhood Hits	162	Target Neighborhood Hits	741	Shared Neighborhood Hits	51
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	2.96777e-27 (rank : 18)	NC score	0.688322 (rank : 29)
Query Neighborhood Hits	162	Target Neighborhood Hits	773	Shared Neighborhood Hits	50
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

EZRI_MOUSE
θ value	2.51237e-26 (rank : 19)	NC score	0.704367 (rank : 26)
Query Neighborhood Hits	162	Target Neighborhood Hits	693	Shared Neighborhood Hits	50
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

MOES_HUMAN
θ value	4.28545e-26 (rank : 20)	NC score	0.652510 (rank : 31)
Query Neighborhood Hits	162	Target Neighborhood Hits	892	Shared Neighborhood Hits	54
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FRMD5_HUMAN
θ value	7.30988e-26 (rank : 21)	NC score	0.853452 (rank : 6)
Query Neighborhood Hits	162	Target Neighborhood Hits	55	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	7.30988e-26 (rank : 22)	NC score	0.855867 (rank : 5)
Query Neighborhood Hits	162	Target Neighborhood Hits	55	Shared Neighborhood Hits	45
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

EZRI_HUMAN
θ value	9.54697e-26 (rank : 23)	NC score	0.708154 (rank : 25)
Query Neighborhood Hits	162	Target Neighborhood Hits	663	Shared Neighborhood Hits	49
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

MOES_MOUSE
θ value	2.12685e-25 (rank : 24)	NC score	0.644933 (rank : 32)
Query Neighborhood Hits	162	Target Neighborhood Hits	923	Shared Neighborhood Hits	55
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FARP2_HUMAN
θ value	6.18819e-25 (rank : 25)	NC score	0.692525 (rank : 27)
Query Neighborhood Hits	162	Target Neighborhood Hits	240	Shared Neighborhood Hits	45
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	1.05554e-24 (rank : 26)	NC score	0.683992 (rank : 30)
Query Neighborhood Hits	162	Target Neighborhood Hits	209	Shared Neighborhood Hits	44
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

E41LA_MOUSE
θ value	5.23862e-24 (rank : 27)	NC score	0.847411 (rank : 8)
Query Neighborhood Hits	162	Target Neighborhood Hits	85	Shared Neighborhood Hits	45
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_HUMAN
θ value	1.16704e-23 (rank : 28)	NC score	0.846554 (rank : 9)
Query Neighborhood Hits	162	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

MERL_HUMAN
θ value	3.39556e-23 (rank : 29)	NC score	0.740176 (rank : 20)
Query Neighborhood Hits	162	Target Neighborhood Hits	532	Shared Neighborhood Hits	51
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	4.43474e-23 (rank : 30)	NC score	0.740137 (rank : 21)
Query Neighborhood Hits	162	Target Neighborhood Hits	524	Shared Neighborhood Hits	49
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

PTN14_MOUSE
θ value	2.20094e-22 (rank : 31)	NC score	0.561370 (rank : 38)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN14_HUMAN
θ value	5.42112e-21 (rank : 32)	NC score	0.553777 (rank : 40)
Query Neighborhood Hits	162	Target Neighborhood Hits	163	Shared Neighborhood Hits	45
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTN21_HUMAN
θ value	7.0802e-21 (rank : 33)	NC score	0.570568 (rank : 37)
Query Neighborhood Hits	162	Target Neighborhood Hits	143	Shared Neighborhood Hits	46
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN21_MOUSE
θ value	1.33526e-19 (rank : 34)	NC score	0.571550 (rank : 36)
Query Neighborhood Hits	162	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

FRM4B_MOUSE
θ value	5.8054e-15 (rank : 35)	NC score	0.746396 (rank : 19)
Query Neighborhood Hits	162	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

FRM4B_HUMAN
θ value	1.29331e-14 (rank : 36)	NC score	0.746546 (rank : 18)
Query Neighborhood Hits	162	Target Neighborhood Hits	117	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4A_HUMAN
θ value	1.86753e-13 (rank : 37)	NC score	0.734696 (rank : 23)
Query Neighborhood Hits	162	Target Neighborhood Hits	110	Shared Neighborhood Hits	46
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_MOUSE
θ value	2.43908e-13 (rank : 38)	NC score	0.735471 (rank : 22)
Query Neighborhood Hits	162	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

BIRC3_MOUSE
θ value	1.74796e-11 (rank : 39)	NC score	0.307294 (rank : 50)
Query Neighborhood Hits	162	Target Neighborhood Hits	113	Shared Neighborhood Hits	73
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC3_HUMAN
θ value	2.98157e-11 (rank : 40)	NC score	0.299377 (rank : 51)
Query Neighborhood Hits	162	Target Neighborhood Hits	133	Shared Neighborhood Hits	74
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC2_MOUSE
θ value	3.89403e-11 (rank : 41)	NC score	0.296838 (rank : 52)
Query Neighborhood Hits	162	Target Neighborhood Hits	137	Shared Neighborhood Hits	76
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC2_HUMAN
θ value	5.08577e-11 (rank : 42)	NC score	0.295955 (rank : 53)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	75
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

PTN13_MOUSE
θ value	4.30538e-10 (rank : 43)	NC score	0.432051 (rank : 42)
Query Neighborhood Hits	162	Target Neighborhood Hits	426	Shared Neighborhood Hits	50
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

BIRC8_HUMAN
θ value	2.13673e-09 (rank : 44)	NC score	0.319650 (rank : 48)
Query Neighborhood Hits	162	Target Neighborhood Hits	121	Shared Neighborhood Hits	71
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC4_HUMAN
θ value	3.64472e-09 (rank : 45)	NC score	0.282802 (rank : 55)
Query Neighborhood Hits	162	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	3.64472e-09 (rank : 46)	NC score	0.280559 (rank : 58)
Query Neighborhood Hits	162	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC7_HUMAN
θ value	1.80886e-08 (rank : 47)	NC score	0.307618 (rank : 49)
Query Neighborhood Hits	162	Target Neighborhood Hits	185	Shared Neighborhood Hits	86
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

PTN13_HUMAN
θ value	2.36244e-08 (rank : 48)	NC score	0.420818 (rank : 43)
Query Neighborhood Hits	162	Target Neighborhood Hits	471	Shared Neighborhood Hits	49
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

FRMD1_HUMAN
θ value	1.17247e-07 (rank : 49)	NC score	0.595463 (rank : 34)
Query Neighborhood Hits	162	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

LRSM1_MOUSE
θ value	4.45536e-07 (rank : 50)	NC score	0.141823 (rank : 69)
Query Neighborhood Hits	162	Target Neighborhood Hits	874	Shared Neighborhood Hits	70
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

LRSM1_HUMAN
θ value	9.92553e-07 (rank : 51)	NC score	0.135985 (rank : 71)
Query Neighborhood Hits	162	Target Neighborhood Hits	1078	Shared Neighborhood Hits	70
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

RFFL_HUMAN
θ value	8.40245e-06 (rank : 52)	NC score	0.277191 (rank : 59)
Query Neighborhood Hits	162	Target Neighborhood Hits	175	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	8.40245e-06 (rank : 53)	NC score	0.280888 (rank : 57)
Query Neighborhood Hits	162	Target Neighborhood Hits	145	Shared Neighborhood Hits	68
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_HUMAN
θ value	1.09739e-05 (rank : 54)	NC score	0.284017 (rank : 54)
Query Neighborhood Hits	162	Target Neighborhood Hits	153	Shared Neighborhood Hits	72
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	1.09739e-05 (rank : 55)	NC score	0.281894 (rank : 56)
Query Neighborhood Hits	162	Target Neighborhood Hits	160	Shared Neighborhood Hits	71
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

MIB1_MOUSE
θ value	2.44474e-05 (rank : 56)	NC score	0.107450 (rank : 82)
Query Neighborhood Hits	162	Target Neighborhood Hits	471	Shared Neighborhood Hits	73
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB1_HUMAN
θ value	5.44631e-05 (rank : 57)	NC score	0.105910 (rank : 86)
Query Neighborhood Hits	162	Target Neighborhood Hits	470	Shared Neighborhood Hits	73
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB2_MOUSE
θ value	0.000121331 (rank : 58)	NC score	0.098799 (rank : 103)
Query Neighborhood Hits	162	Target Neighborhood Hits	409	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

RKHD1_HUMAN
θ value	0.000158464 (rank : 59)	NC score	0.243832 (rank : 61)
Query Neighborhood Hits	162	Target Neighborhood Hits	163	Shared Neighborhood Hits	62
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

CGRF1_HUMAN
θ value	0.000270298 (rank : 60)	NC score	0.231318 (rank : 62)
Query Neighborhood Hits	162	Target Neighborhood Hits	51	Shared Neighborhood Hits	40
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

MIB2_HUMAN
θ value	0.000270298 (rank : 61)	NC score	0.102155 (rank : 89)
Query Neighborhood Hits	162	Target Neighborhood Hits	438	Shared Neighborhood Hits	64
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

PEX10_HUMAN
θ value	0.00102713 (rank : 62)	NC score	0.152402 (rank : 68)
Query Neighborhood Hits	162	Target Neighborhood Hits	255	Shared Neighborhood Hits	83
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

CGRF1_MOUSE
θ value	0.00134147 (rank : 63)	NC score	0.220542 (rank : 63)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

UHRF1_MOUSE
θ value	0.00509761 (rank : 64)	NC score	0.086306 (rank : 130)
Query Neighborhood Hits	162	Target Neighborhood Hits	278	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

NEURL_MOUSE
θ value	0.00665767 (rank : 65)	NC score	0.194283 (rank : 64)
Query Neighborhood Hits	162	Target Neighborhood Hits	106	Shared Neighborhood Hits	65
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
θ value	0.0148317 (rank : 66)	NC score	0.189891 (rank : 65)
Query Neighborhood Hits	162	Target Neighborhood Hits	114	Shared Neighborhood Hits	66
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

RNF26_HUMAN
θ value	0.0148317 (rank : 67)	NC score	0.245675 (rank : 60)
Query Neighborhood Hits	162	Target Neighborhood Hits	95	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

TLN1_HUMAN
θ value	0.0148317 (rank : 68)	NC score	0.357762 (rank : 44)
Query Neighborhood Hits	162	Target Neighborhood Hits	218	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN2_MOUSE
θ value	0.0193708 (rank : 69)	NC score	0.346572 (rank : 46)
Query Neighborhood Hits	162	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TRI35_MOUSE
θ value	0.0193708 (rank : 70)	NC score	0.083900 (rank : 136)
Query Neighborhood Hits	162	Target Neighborhood Hits	465	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRI35_HUMAN
θ value	0.0252991 (rank : 71)	NC score	0.080725 (rank : 143)
Query Neighborhood Hits	162	Target Neighborhood Hits	382	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

CBLB_HUMAN
θ value	0.0330416 (rank : 72)	NC score	0.130853 (rank : 74)
Query Neighborhood Hits	162	Target Neighborhood Hits	261	Shared Neighborhood Hits	78
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBLB_MOUSE
θ value	0.0330416 (rank : 73)	NC score	0.131053 (rank : 73)
Query Neighborhood Hits	162	Target Neighborhood Hits	277	Shared Neighborhood Hits	78
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBLC_MOUSE
θ value	0.0330416 (rank : 74)	NC score	0.139119 (rank : 70)
Query Neighborhood Hits	162	Target Neighborhood Hits	186	Shared Neighborhood Hits	73
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

TLN1_MOUSE
θ value	0.0330416 (rank : 75)	NC score	0.353531 (rank : 45)
Query Neighborhood Hits	162	Target Neighborhood Hits	213	Shared Neighborhood Hits	46
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TLN2_HUMAN
θ value	0.0330416 (rank : 76)	NC score	0.341566 (rank : 47)
Query Neighborhood Hits	162	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

CBL_HUMAN
θ value	0.0431538 (rank : 77)	NC score	0.130500 (rank : 75)
Query Neighborhood Hits	162	Target Neighborhood Hits	353	Shared Neighborhood Hits	80
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
θ value	0.0431538 (rank : 78)	NC score	0.127516 (rank : 76)
Query Neighborhood Hits	162	Target Neighborhood Hits	426	Shared Neighborhood Hits	81
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

UHRF2_MOUSE
θ value	0.0431538 (rank : 79)	NC score	0.088795 (rank : 127)
Query Neighborhood Hits	162	Target Neighborhood Hits	275	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

MGRN1_HUMAN
θ value	0.0736092 (rank : 80)	NC score	0.160392 (rank : 67)
Query Neighborhood Hits	162	Target Neighborhood Hits	192	Shared Neighborhood Hits	66
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MGRN1_MOUSE
θ value	0.0736092 (rank : 81)	NC score	0.164349 (rank : 66)
Query Neighborhood Hits	162	Target Neighborhood Hits	149	Shared Neighborhood Hits	66
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

UHRF2_HUMAN
θ value	0.0736092 (rank : 82)	NC score	0.085838 (rank : 131)
Query Neighborhood Hits	162	Target Neighborhood Hits	269	Shared Neighborhood Hits	58
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

ZC3H5_MOUSE
θ value	0.0961366 (rank : 83)	NC score	0.076769 (rank : 156)
Query Neighborhood Hits	162	Target Neighborhood Hits	136	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

CBLC_HUMAN
θ value	0.125558 (rank : 84)	NC score	0.131295 (rank : 72)
Query Neighborhood Hits	162	Target Neighborhood Hits	173	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

LNX2_HUMAN
θ value	0.125558 (rank : 85)	NC score	0.064940 (rank : 182)
Query Neighborhood Hits	162	Target Neighborhood Hits	389	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

TRI37_HUMAN
θ value	0.125558 (rank : 86)	NC score	0.079268 (rank : 152)
Query Neighborhood Hits	162	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	0.125558 (rank : 87)	NC score	0.080159 (rank : 146)
Query Neighborhood Hits	162	Target Neighborhood Hits	316	Shared Neighborhood Hits	60
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRIM2_HUMAN
θ value	0.163984 (rank : 88)	NC score	0.073780 (rank : 164)
Query Neighborhood Hits	162	Target Neighborhood Hits	330	Shared Neighborhood Hits	76
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

MYO10_HUMAN
θ value	0.21417 (rank : 89)	NC score	0.037187 (rank : 258)
Query Neighborhood Hits	162	Target Neighborhood Hits	920	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

RO52_HUMAN
θ value	0.21417 (rank : 90)	NC score	0.076726 (rank : 157)
Query Neighborhood Hits	162	Target Neighborhood Hits	419	Shared Neighborhood Hits	92
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

TRI12_MOUSE
θ value	0.21417 (rank : 91)	NC score	0.077320 (rank : 155)
Query Neighborhood Hits	162	Target Neighborhood Hits	387	Shared Neighborhood Hits	79
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

TRIM2_MOUSE
θ value	0.21417 (rank : 92)	NC score	0.072799 (rank : 169)
Query Neighborhood Hits	162	Target Neighborhood Hits	331	Shared Neighborhood Hits	76
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

RNF8_MOUSE
θ value	0.365318 (rank : 93)	NC score	0.099918 (rank : 98)
Query Neighborhood Hits	162	Target Neighborhood Hits	618	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

TRAF7_MOUSE
θ value	0.47712 (rank : 94)	NC score	0.033064 (rank : 259)
Query Neighborhood Hits	162	Target Neighborhood Hits	470	Shared Neighborhood Hits	65
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TRI26_MOUSE
θ value	0.47712 (rank : 95)	NC score	0.085629 (rank : 132)
Query Neighborhood Hits	162	Target Neighborhood Hits	339	Shared Neighborhood Hits	97
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI27_MOUSE
θ value	0.47712 (rank : 96)	NC score	0.063735 (rank : 186)
Query Neighborhood Hits	162	Target Neighborhood Hits	261	Shared Neighborhood Hits	90
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

ZC3H5_HUMAN
θ value	0.47712 (rank : 97)	NC score	0.072662 (rank : 170)
Query Neighborhood Hits	162	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

TRAF7_HUMAN
θ value	0.62314 (rank : 98)	NC score	0.032865 (rank : 260)
Query Neighborhood Hits	162	Target Neighborhood Hits	482	Shared Neighborhood Hits	65
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

UHRF1_HUMAN
θ value	0.62314 (rank : 99)	NC score	0.071175 (rank : 173)
Query Neighborhood Hits	162	Target Neighborhood Hits	272	Shared Neighborhood Hits	59
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

LNX2_MOUSE
θ value	0.813845 (rank : 100)	NC score	0.060007 (rank : 199)
Query Neighborhood Hits	162	Target Neighborhood Hits	407	Shared Neighborhood Hits	68
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

MUC5B_HUMAN
θ value	0.813845 (rank : 101)	NC score	0.012327 (rank : 268)
Query Neighborhood Hits	162	Target Neighborhood Hits	1020	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

RN168_HUMAN
θ value	0.813845 (rank : 102)	NC score	0.101523 (rank : 94)
Query Neighborhood Hits	162	Target Neighborhood Hits	370	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN169_HUMAN
θ value	0.813845 (rank : 103)	NC score	0.084552 (rank : 134)
Query Neighborhood Hits	162	Target Neighborhood Hits	203	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

TRI26_HUMAN
θ value	0.813845 (rank : 104)	NC score	0.084189 (rank : 135)
Query Neighborhood Hits	162	Target Neighborhood Hits	335	Shared Neighborhood Hits	94
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI50_HUMAN
θ value	0.813845 (rank : 105)	NC score	0.069873 (rank : 176)
Query Neighborhood Hits	162	Target Neighborhood Hits	294	Shared Neighborhood Hits	92
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

MDM2_HUMAN
θ value	1.06291 (rank : 106)	NC score	0.075786 (rank : 160)
Query Neighborhood Hits	162	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

RN123_MOUSE
θ value	1.06291 (rank : 107)	NC score	0.067904 (rank : 179)
Query Neighborhood Hits	162	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

RO52_MOUSE
θ value	1.06291 (rank : 108)	NC score	0.070725 (rank : 174)
Query Neighborhood Hits	162	Target Neighborhood Hits	360	Shared Neighborhood Hits	87
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

RNF8_HUMAN
θ value	1.38821 (rank : 109)	NC score	0.088462 (rank : 129)
Query Neighborhood Hits	162	Target Neighborhood Hits	622	Shared Neighborhood Hits	89
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

TRI27_HUMAN
θ value	1.38821 (rank : 110)	NC score	0.058667 (rank : 205)
Query Neighborhood Hits	162	Target Neighborhood Hits	273	Shared Neighborhood Hits	86
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

TRI42_HUMAN
θ value	1.38821 (rank : 111)	NC score	0.044832 (rank : 251)
Query Neighborhood Hits	162	Target Neighborhood Hits	283	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI56_HUMAN
θ value	1.38821 (rank : 112)	NC score	0.071879 (rank : 172)
Query Neighborhood Hits	162	Target Neighborhood Hits	339	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

TRI56_MOUSE
θ value	1.38821 (rank : 113)	NC score	0.069973 (rank : 175)
Query Neighborhood Hits	162	Target Neighborhood Hits	255	Shared Neighborhood Hits	69
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

KRA93_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.012862 (rank : 267)
Query Neighborhood Hits	162	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

RFWD2_HUMAN
θ value	1.81305 (rank : 115)	NC score	0.041779 (rank : 255)
Query Neighborhood Hits	162	Target Neighborhood Hits	518	Shared Neighborhood Hits	76
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RFWD2_MOUSE
θ value	1.81305 (rank : 116)	NC score	0.043408 (rank : 252)
Query Neighborhood Hits	162	Target Neighborhood Hits	535	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RN123_HUMAN
θ value	1.81305 (rank : 117)	NC score	0.064782 (rank : 183)
Query Neighborhood Hits	162	Target Neighborhood Hits	175	Shared Neighborhood Hits	58
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRI32_HUMAN
θ value	1.81305 (rank : 118)	NC score	0.067558 (rank : 181)
Query Neighborhood Hits	162	Target Neighborhood Hits	264	Shared Neighborhood Hits	64
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	1.81305 (rank : 119)	NC score	0.073147 (rank : 167)
Query Neighborhood Hits	162	Target Neighborhood Hits	271	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

BRE1B_HUMAN
θ value	2.36792 (rank : 120)	NC score	0.043404 (rank : 253)
Query Neighborhood Hits	162	Target Neighborhood Hits	1040	Shared Neighborhood Hits	67
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	2.36792 (rank : 121)	NC score	0.045451 (rank : 250)
Query Neighborhood Hits	162	Target Neighborhood Hits	970	Shared Neighborhood Hits	67
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

FRAS1_MOUSE
θ value	2.36792 (rank : 122)	NC score	0.005329 (rank : 272)
Query Neighborhood Hits	162	Target Neighborhood Hits	747	Shared Neighborhood Hits	12
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

HMDH_MOUSE
θ value	2.36792 (rank : 123)	NC score	0.022936 (rank : 264)
Query Neighborhood Hits	162	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

MDM4_HUMAN
θ value	2.36792 (rank : 124)	NC score	0.080201 (rank : 145)
Query Neighborhood Hits	162	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

RN168_MOUSE
θ value	2.36792 (rank : 125)	NC score	0.085543 (rank : 133)
Query Neighborhood Hits	162	Target Neighborhood Hits	440	Shared Neighborhood Hits	83
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI31_HUMAN
θ value	2.36792 (rank : 126)	NC score	0.080227 (rank : 144)
Query Neighborhood Hits	162	Target Neighborhood Hits	299	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

TRI50_MOUSE
θ value	2.36792 (rank : 127)	NC score	0.073175 (rank : 166)
Query Neighborhood Hits	162	Target Neighborhood Hits	326	Shared Neighborhood Hits	98
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

ZNF23_HUMAN
θ value	2.36792 (rank : 128)	NC score	-0.006562 (rank : 275)
Query Neighborhood Hits	162	Target Neighborhood Hits	750	Shared Neighborhood Hits	3
SwissProt Accessions	P17027, Q96IT3, Q9UG42	Gene names	ZNF23, KOX16, ZNF359
Domain Architecture
Description	Zinc finger protein 23 (Zinc finger protein 359) (Zinc finger protein KOX16).

RNF24_MOUSE
θ value	3.0926 (rank : 129)	NC score	0.028777 (rank : 261)
Query Neighborhood Hits	162	Target Neighborhood Hits	124	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BGI1	Gene names	Rnf24
Domain Architecture	No domain graphic available
Description	RING finger protein 24.

TRI42_MOUSE
θ value	3.0926 (rank : 130)	NC score	0.043145 (rank : 254)
Query Neighborhood Hits	162	Target Neighborhood Hits	316	Shared Neighborhood Hits	57
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

KRA98_HUMAN
θ value	4.03905 (rank : 131)	NC score	0.010790 (rank : 270)
Query Neighborhood Hits	162	Target Neighborhood Hits	185	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

RNF24_HUMAN
θ value	4.03905 (rank : 132)	NC score	0.024633 (rank : 262)
Query Neighborhood Hits	162	Target Neighborhood Hits	122	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y225, Q9UMH1	Gene names	RNF24
Domain Architecture
Description	RING finger protein 24.

TR10B_MOUSE
θ value	4.03905 (rank : 133)	NC score	0.009667 (rank : 271)
Query Neighborhood Hits	162	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QZM4, Q9JJL5, Q9JJL6	Gene names	Tnfrsf10b, Dr5, Killer
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (MK).

TRI73_HUMAN
θ value	4.03905 (rank : 134)	NC score	0.073751 (rank : 165)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	84
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

CI085_MOUSE
θ value	5.27518 (rank : 135)	NC score	0.018352 (rank : 266)
Query Neighborhood Hits	162	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQ90	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf85 homolog.

TRI22_HUMAN
θ value	5.27518 (rank : 136)	NC score	0.051695 (rank : 231)
Query Neighborhood Hits	162	Target Neighborhood Hits	396	Shared Neighborhood Hits	71
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRI25_MOUSE
θ value	5.27518 (rank : 137)	NC score	0.060324 (rank : 198)
Query Neighborhood Hits	162	Target Neighborhood Hits	446	Shared Neighborhood Hits	80
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

TRI34_MOUSE
θ value	5.27518 (rank : 138)	NC score	0.050260 (rank : 243)
Query Neighborhood Hits	162	Target Neighborhood Hits	332	Shared Neighborhood Hits	64
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRIM5_HUMAN
θ value	5.27518 (rank : 139)	NC score	0.058165 (rank : 207)
Query Neighborhood Hits	162	Target Neighborhood Hits	424	Shared Neighborhood Hits	81
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

BRCA1_MOUSE
θ value	6.88961 (rank : 140)	NC score	0.054975 (rank : 215)
Query Neighborhood Hits	162	Target Neighborhood Hits	436	Shared Neighborhood Hits	79
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

LNX1_MOUSE
θ value	6.88961 (rank : 141)	NC score	0.051311 (rank : 235)
Query Neighborhood Hits	162	Target Neighborhood Hits	377	Shared Neighborhood Hits	66
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

PML_HUMAN
θ value	6.88961 (rank : 142)	NC score	0.053105 (rank : 223)
Query Neighborhood Hits	162	Target Neighborhood Hits	248	Shared Neighborhood Hits	54
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

RECQ5_HUMAN
θ value	6.88961 (rank : 143)	NC score	0.004061 (rank : 273)
Query Neighborhood Hits	162	Target Neighborhood Hits	390	Shared Neighborhood Hits	4
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

SIA1A_MOUSE
θ value	6.88961 (rank : 144)	NC score	0.052754 (rank : 226)
Query Neighborhood Hits	162	Target Neighborhood Hits	72	Shared Neighborhood Hits	33
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIA1B_MOUSE
θ value	6.88961 (rank : 145)	NC score	0.053531 (rank : 221)
Query Neighborhood Hits	162	Target Neighborhood Hits	69	Shared Neighborhood Hits	33
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

SIAH1_HUMAN
θ value	6.88961 (rank : 146)	NC score	0.053001 (rank : 225)
Query Neighborhood Hits	162	Target Neighborhood Hits	72	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

TRI25_HUMAN
θ value	6.88961 (rank : 147)	NC score	0.052425 (rank : 229)
Query Neighborhood Hits	162	Target Neighborhood Hits	472	Shared Neighborhood Hits	80
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRI46_HUMAN
θ value	6.88961 (rank : 148)	NC score	0.041179 (rank : 256)
Query Neighborhood Hits	162	Target Neighborhood Hits	291	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI46_MOUSE
θ value	6.88961 (rank : 149)	NC score	0.040850 (rank : 257)
Query Neighborhood Hits	162	Target Neighborhood Hits	287	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI74_HUMAN
θ value	6.88961 (rank : 150)	NC score	0.068949 (rank : 177)
Query Neighborhood Hits	162	Target Neighborhood Hits	249	Shared Neighborhood Hits	81
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

TRIM3_HUMAN
θ value	6.88961 (rank : 151)	NC score	0.061799 (rank : 191)
Query Neighborhood Hits	162	Target Neighborhood Hits	357	Shared Neighborhood Hits	75
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRIM3_MOUSE
θ value	6.88961 (rank : 152)	NC score	0.059095 (rank : 202)
Query Neighborhood Hits	162	Target Neighborhood Hits	351	Shared Neighborhood Hits	69
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

AMFR2_HUMAN
θ value	8.99809 (rank : 153)	NC score	0.048099 (rank : 248)
Query Neighborhood Hits	162	Target Neighborhood Hits	219	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

AMFR_MOUSE
θ value	8.99809 (rank : 154)	NC score	0.047699 (rank : 249)
Query Neighborhood Hits	162	Target Neighborhood Hits	208	Shared Neighborhood Hits	60
SwissProt Accessions	Q9R049, Q8K008, Q99LH5	Gene names	Amfr
Domain Architecture
Description	Autocrine motility factor receptor (EC 6.3.2.19) (AMF receptor).

CI085_HUMAN
θ value	8.99809 (rank : 155)	NC score	0.012142 (rank : 269)
Query Neighborhood Hits	162	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q96MD7, Q5W0N1, Q5W0N3, Q6PJW9, Q86U95	Gene names	C9orf85
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf85.

CNOT4_HUMAN
θ value	8.99809 (rank : 156)	NC score	0.023323 (rank : 263)
Query Neighborhood Hits	162	Target Neighborhood Hits	207	Shared Neighborhood Hits	23
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CNOT4_MOUSE
θ value	8.99809 (rank : 157)	NC score	0.022189 (rank : 265)
Query Neighborhood Hits	162	Target Neighborhood Hits	277	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

LNX1_HUMAN
θ value	8.99809 (rank : 158)	NC score	0.049117 (rank : 247)
Query Neighborhood Hits	162	Target Neighborhood Hits	379	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MYCB2_MOUSE
θ value	8.99809 (rank : 159)	NC score	0.003840 (rank : 274)
Query Neighborhood Hits	162	Target Neighborhood Hits	307	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

SIAH2_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.061271 (rank : 194)
Query Neighborhood Hits	162	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

SIAH2_MOUSE
θ value	8.99809 (rank : 161)	NC score	0.061749 (rank : 192)
Query Neighborhood Hits	162	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

TRI65_MOUSE
θ value	8.99809 (rank : 162)	NC score	0.068694 (rank : 178)
Query Neighborhood Hits	162	Target Neighborhood Hits	340	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

BFAR_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.050317 (rank : 242)
Query Neighborhood Hits	162	Target Neighborhood Hits	222	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BFAR_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.051672 (rank : 232)
Query Neighborhood Hits	162	Target Neighborhood Hits	232	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

BIR1A_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.081091 (rank : 142)
Query Neighborhood Hits	162	Target Neighborhood Hits	94	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1B_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.082809 (rank : 138)
Query Neighborhood Hits	162	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1E_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.082779 (rank : 139)
Query Neighborhood Hits	162	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.082473 (rank : 140)
Query Neighborhood Hits	162	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.082387 (rank : 141)
Query Neighborhood Hits	162	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIRC1_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.083342 (rank : 137)
Query Neighborhood Hits	162	Target Neighborhood Hits	61	Shared Neighborhood Hits	8
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIRC5_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.093837 (rank : 117)
Query Neighborhood Hits	162	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.100410 (rank : 97)
Query Neighborhood Hits	162	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC6_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.061224 (rank : 195)
Query Neighborhood Hits	162	Target Neighborhood Hits	161	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

BRCA1_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.050229 (rank : 244)
Query Neighborhood Hits	162	Target Neighborhood Hits	381	Shared Neighborhood Hits	77
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

CA106_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.091627 (rank : 122)
Query Neighborhood Hits	162	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CA106_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.090115 (rank : 123)
Query Neighborhood Hits	162	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CCD50_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.050429 (rank : 241)
Query Neighborhood Hits	162	Target Neighborhood Hits	237	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IVM0, Q86VH7	Gene names	CCDC50, C3orf6
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

CD45_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.092765 (rank : 121)
Query Neighborhood Hits	162	Target Neighborhood Hits	243	Shared Neighborhood Hits	10
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.096560 (rank : 108)
Query Neighborhood Hits	162	Target Neighborhood Hits	178	Shared Neighborhood Hits	12
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

CHFR_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.058967 (rank : 204)
Query Neighborhood Hits	162	Target Neighborhood Hits	255	Shared Neighborhood Hits	69
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

CHFR_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.056851 (rank : 211)
Query Neighborhood Hits	162	Target Neighborhood Hits	264	Shared Neighborhood Hits	71
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

FGD4_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.050685 (rank : 239)
Query Neighborhood Hits	162	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.051020 (rank : 237)
Query Neighborhood Hits	162	Target Neighborhood Hits	227	Shared Neighborhood Hits	4
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD5_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.056126 (rank : 213)
Query Neighborhood Hits	162	Target Neighborhood Hits	235	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.053086 (rank : 224)
Query Neighborhood Hits	162	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.052599 (rank : 228)
Query Neighborhood Hits	162	Target Neighborhood Hits	237	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.052254 (rank : 230)
Query Neighborhood Hits	162	Target Neighborhood Hits	282	Shared Neighborhood Hits	4
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FRMD6_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.549963 (rank : 41)
Query Neighborhood Hits	162	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

FRMD6_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.555870 (rank : 39)
Query Neighborhood Hits	162	Target Neighborhood Hits	63	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

HIP1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.052634 (rank : 227)
Query Neighborhood Hits	162	Target Neighborhood Hits	1016	Shared Neighborhood Hits	29
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

KRIT1_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.099343 (rank : 100)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

KRIT1_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.092951 (rank : 120)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

MDM2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.051369 (rank : 233)
Query Neighborhood Hits	162	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

PTN11_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.095192 (rank : 113)
Query Neighborhood Hits	162	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.095196 (rank : 112)
Query Neighborhood Hits	162	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN12_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.101513 (rank : 95)
Query Neighborhood Hits	162	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.101217 (rank : 96)
Query Neighborhood Hits	162	Target Neighborhood Hits	123	Shared Neighborhood Hits	8
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN18_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.110136 (rank : 80)
Query Neighborhood Hits	162	Target Neighborhood Hits	73	Shared Neighborhood Hits	8
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.106758 (rank : 84)
Query Neighborhood Hits	162	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN1_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.110209 (rank : 79)
Query Neighborhood Hits	162	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.110549 (rank : 78)
Query Neighborhood Hits	162	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN22_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.103577 (rank : 87)
Query Neighborhood Hits	162	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.102143 (rank : 90)
Query Neighborhood Hits	162	Target Neighborhood Hits	179	Shared Neighborhood Hits	10
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.094035 (rank : 116)
Query Neighborhood Hits	162	Target Neighborhood Hits	646	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.092966 (rank : 119)
Query Neighborhood Hits	162	Target Neighborhood Hits	726	Shared Neighborhood Hits	14
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN2_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.110062 (rank : 81)
Query Neighborhood Hits	162	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.111218 (rank : 77)
Query Neighborhood Hits	162	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN5_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.095655 (rank : 110)
Query Neighborhood Hits	162	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.095761 (rank : 109)
Query Neighborhood Hits	162	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN6_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.101594 (rank : 92)
Query Neighborhood Hits	162	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.101567 (rank : 93)
Query Neighborhood Hits	162	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.101775 (rank : 91)
Query Neighborhood Hits	162	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.102903 (rank : 88)
Query Neighborhood Hits	162	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.106934 (rank : 83)
Query Neighborhood Hits	162	Target Neighborhood Hits	79	Shared Neighborhood Hits	8
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.106598 (rank : 85)
Query Neighborhood Hits	162	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPR2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.098778 (rank : 104)
Query Neighborhood Hits	162	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.098898 (rank : 102)
Query Neighborhood Hits	162	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRA_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.089046 (rank : 124)
Query Neighborhood Hits	162	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.089035 (rank : 126)
Query Neighborhood Hits	162	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRB_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.093014 (rank : 118)
Query Neighborhood Hits	162	Target Neighborhood Hits	242	Shared Neighborhood Hits	8
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRD_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.060958 (rank : 196)
Query Neighborhood Hits	162	Target Neighborhood Hits	485	Shared Neighborhood Hits	10
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.058540 (rank : 206)
Query Neighborhood Hits	162	Target Neighborhood Hits	491	Shared Neighborhood Hits	9
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRE_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.089042 (rank : 125)
Query Neighborhood Hits	162	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.088500 (rank : 128)
Query Neighborhood Hits	162	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRF_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.059181 (rank : 201)
Query Neighborhood Hits	162	Target Neighborhood Hits	489	Shared Neighborhood Hits	8
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRG_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.078863 (rank : 154)
Query Neighborhood Hits	162	Target Neighborhood Hits	231	Shared Neighborhood Hits	8
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.079093 (rank : 153)
Query Neighborhood Hits	162	Target Neighborhood Hits	260	Shared Neighborhood Hits	9
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRJ_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.094960 (rank : 114)
Query Neighborhood Hits	162	Target Neighborhood Hits	207	Shared Neighborhood Hits	8
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.095623 (rank : 111)
Query Neighborhood Hits	162	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRK_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.079405 (rank : 151)
Query Neighborhood Hits	162	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.080069 (rank : 148)
Query Neighborhood Hits	162	Target Neighborhood Hits	223	Shared Neighborhood Hits	8
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRM_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.074550 (rank : 163)
Query Neighborhood Hits	162	Target Neighborhood Hits	244	Shared Neighborhood Hits	8
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.074970 (rank : 161)
Query Neighborhood Hits	162	Target Neighborhood Hits	238	Shared Neighborhood Hits	8
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRN_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.099174 (rank : 101)
Query Neighborhood Hits	162	Target Neighborhood Hits	156	Shared Neighborhood Hits	10
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.098639 (rank : 105)
Query Neighborhood Hits	162	Target Neighborhood Hits	240	Shared Neighborhood Hits	9
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRO_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.099371 (rank : 99)
Query Neighborhood Hits	162	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRR_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.097204 (rank : 107)
Query Neighborhood Hits	162	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.097708 (rank : 106)
Query Neighborhood Hits	162	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRS_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.062398 (rank : 189)
Query Neighborhood Hits	162	Target Neighborhood Hits	472	Shared Neighborhood Hits	11
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRT_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.076673 (rank : 158)
Query Neighborhood Hits	162	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.076632 (rank : 159)
Query Neighborhood Hits	162	Target Neighborhood Hits	219	Shared Neighborhood Hits	8
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRU_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.074815 (rank : 162)
Query Neighborhood Hits	162	Target Neighborhood Hits	237	Shared Neighborhood Hits	8
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRV_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.094692 (rank : 115)
Query Neighborhood Hits	162	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTPRZ_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.079626 (rank : 149)
Query Neighborhood Hits	162	Target Neighborhood Hits	255	Shared Neighborhood Hits	9
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

RN125_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.059311 (rank : 200)
Query Neighborhood Hits	162	Target Neighborhood Hits	230	Shared Neighborhood Hits	71
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

RN125_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.053652 (rank : 220)
Query Neighborhood Hits	162	Target Neighborhood Hits	220	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

RN141_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.057184 (rank : 209)
Query Neighborhood Hits	162	Target Neighborhood Hits	199	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.057036 (rank : 210)
Query Neighborhood Hits	162	Target Neighborhood Hits	200	Shared Neighborhood Hits	58
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN185_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.080158 (rank : 147)
Query Neighborhood Hits	162	Target Neighborhood Hits	213	Shared Neighborhood Hits	74
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.079542 (rank : 150)
Query Neighborhood Hits	162	Target Neighborhood Hits	211	Shared Neighborhood Hits	74
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RNF5_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.072928 (rank : 168)
Query Neighborhood Hits	162	Target Neighborhood Hits	206	Shared Neighborhood Hits	80
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RNF5_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.071995 (rank : 171)
Query Neighborhood Hits	162	Target Neighborhood Hits	206	Shared Neighborhood Hits	80
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

TRI11_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.054532 (rank : 217)
Query Neighborhood Hits	162	Target Neighborhood Hits	316	Shared Neighborhood Hits	85
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI11_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.054453 (rank : 218)
Query Neighborhood Hits	162	Target Neighborhood Hits	329	Shared Neighborhood Hits	84
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI13_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.050702 (rank : 238)
Query Neighborhood Hits	162	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRI15_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.050098 (rank : 246)
Query Neighborhood Hits	162	Target Neighborhood Hits	395	Shared Neighborhood Hits	70
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

TRI17_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.054438 (rank : 219)
Query Neighborhood Hits	162	Target Neighborhood Hits	318	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRI17_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.063007 (rank : 187)
Query Neighborhood Hits	162	Target Neighborhood Hits	620	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

TRI30_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.053232 (rank : 222)
Query Neighborhood Hits	162	Target Neighborhood Hits	434	Shared Neighborhood Hits	74
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TRI34_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.050478 (rank : 240)
Query Neighborhood Hits	162	Target Neighborhood Hits	416	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRI39_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.063903 (rank : 185)
Query Neighborhood Hits	162	Target Neighborhood Hits	693	Shared Neighborhood Hits	93
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI39_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.061842 (rank : 190)
Query Neighborhood Hits	162	Target Neighborhood Hits	691	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI40_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.067700 (rank : 180)
Query Neighborhood Hits	162	Target Neighborhood Hits	279	Shared Neighborhood Hits	81
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI43_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.056077 (rank : 214)
Query Neighborhood Hits	162	Target Neighborhood Hits	341	Shared Neighborhood Hits	83
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI52_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.060735 (rank : 197)
Query Neighborhood Hits	162	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TRI59_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.051369 (rank : 234)
Query Neighborhood Hits	162	Target Neighborhood Hits	292	Shared Neighborhood Hits	70
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI60_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.059006 (rank : 203)
Query Neighborhood Hits	162	Target Neighborhood Hits	357	Shared Neighborhood Hits	89
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

TRI65_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.062447 (rank : 188)
Query Neighborhood Hits	162	Target Neighborhood Hits	330	Shared Neighborhood Hits	78
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI68_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.051059 (rank : 236)
Query Neighborhood Hits	162	Target Neighborhood Hits	356	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

TRIM4_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.054895 (rank : 216)
Query Neighborhood Hits	162	Target Neighborhood Hits	321	Shared Neighborhood Hits	83
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

TRIM6_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.050169 (rank : 245)
Query Neighborhood Hits	162	Target Neighborhood Hits	451	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

TRIM8_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.057664 (rank : 208)
Query Neighborhood Hits	162	Target Neighborhood Hits	650	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM8_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.056746 (rank : 212)
Query Neighborhood Hits	162	Target Neighborhood Hits	674	Shared Neighborhood Hits	69
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

ZN313_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.061684 (rank : 193)
Query Neighborhood Hits	162	Target Neighborhood Hits	264	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

ZN313_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.064553 (rank : 184)
Query Neighborhood Hits	162	Target Neighborhood Hits	273	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

Hits sorted by NC score

MYLIP_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	162	Target Neighborhood Hits	162	Shared Neighborhood Hits	162
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
NC score	0.994821 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	162	Target Neighborhood Hits	139	Shared Neighborhood Hits	128
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

E41L5_HUMAN
NC score	0.859683 (rank : 3)	θ value	2.42779e-29 (rank : 5)
Query Neighborhood Hits	162	Target Neighborhood Hits	76	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.858310 (rank : 4)	θ value	4.14116e-29 (rank : 6)
Query Neighborhood Hits	162	Target Neighborhood Hits	59	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

FRMD5_MOUSE
NC score	0.855867 (rank : 5)	θ value	7.30988e-26 (rank : 22)
Query Neighborhood Hits	162	Target Neighborhood Hits	55	Shared Neighborhood Hits	45
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_HUMAN
NC score	0.853452 (rank : 6)	θ value	7.30988e-26 (rank : 21)
Query Neighborhood Hits	162	Target Neighborhood Hits	55	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41LB_HUMAN
NC score	0.852527 (rank : 7)	θ value	1.2049e-28 (rank : 7)
Query Neighborhood Hits	162	Target Neighborhood Hits	79	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LA_MOUSE
NC score	0.847411 (rank : 8)	θ value	5.23862e-24 (rank : 27)
Query Neighborhood Hits	162	Target Neighborhood Hits	85	Shared Neighborhood Hits	45
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_HUMAN
NC score	0.846554 (rank : 9)	θ value	1.16704e-23 (rank : 28)
Query Neighborhood Hits	162	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41L3_HUMAN
NC score	0.846151 (rank : 10)	θ value	1.73987e-27 (rank : 14)
Query Neighborhood Hits	162	Target Neighborhood Hits	113	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L1_MOUSE
NC score	0.842679 (rank : 11)	θ value	2.27234e-27 (rank : 15)
Query Neighborhood Hits	162	Target Neighborhood Hits	106	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

41_HUMAN
NC score	0.840837 (rank : 12)	θ value	3.50572e-28 (rank : 9)
Query Neighborhood Hits	162	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L1_HUMAN
NC score	0.838209 (rank : 13)	θ value	1.02001e-27 (rank : 11)
Query Neighborhood Hits	162	Target Neighborhood Hits	180	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

41_MOUSE
NC score	0.838008 (rank : 14)	θ value	3.50572e-28 (rank : 10)
Query Neighborhood Hits	162	Target Neighborhood Hits	184	Shared Neighborhood Hits	45
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L3_MOUSE
NC score	0.833915 (rank : 15)	θ value	1.02001e-27 (rank : 12)
Query Neighborhood Hits	162	Target Neighborhood Hits	250	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L2_HUMAN
NC score	0.831368 (rank : 16)	θ value	1.57365e-28 (rank : 8)
Query Neighborhood Hits	162	Target Neighborhood Hits	287	Shared Neighborhood Hits	47
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
NC score	0.812270 (rank : 17)	θ value	1.33217e-27 (rank : 13)
Query Neighborhood Hits	162	Target Neighborhood Hits	459	Shared Neighborhood Hits	46
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

FRM4B_HUMAN
NC score	0.746546 (rank : 18)	θ value	1.29331e-14 (rank : 36)
Query Neighborhood Hits	162	Target Neighborhood Hits	117	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
NC score	0.746396 (rank : 19)	θ value	5.8054e-15 (rank : 35)
Query Neighborhood Hits	162	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

MERL_HUMAN
NC score	0.740176 (rank : 20)	θ value	3.39556e-23 (rank : 29)
Query Neighborhood Hits	162	Target Neighborhood Hits	532	Shared Neighborhood Hits	51
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
NC score	0.740137 (rank : 21)	θ value	4.43474e-23 (rank : 30)
Query Neighborhood Hits	162	Target Neighborhood Hits	524	Shared Neighborhood Hits	49
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

FRM4A_MOUSE
NC score	0.735471 (rank : 22)	θ value	2.43908e-13 (rank : 38)
Query Neighborhood Hits	162	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_HUMAN
NC score	0.734696 (rank : 23)	θ value	1.86753e-13 (rank : 37)
Query Neighborhood Hits	162	Target Neighborhood Hits	110	Shared Neighborhood Hits	46
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FARP1_HUMAN
NC score	0.715513 (rank : 24)	θ value	2.96777e-27 (rank : 16)
Query Neighborhood Hits	162	Target Neighborhood Hits	241	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

EZRI_HUMAN
NC score	0.708154 (rank : 25)	θ value	9.54697e-26 (rank : 23)
Query Neighborhood Hits	162	Target Neighborhood Hits	663	Shared Neighborhood Hits	49
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
NC score	0.704367 (rank : 26)	θ value	2.51237e-26 (rank : 19)
Query Neighborhood Hits	162	Target Neighborhood Hits	693	Shared Neighborhood Hits	50
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FARP2_HUMAN
NC score	0.692525 (rank : 27)	θ value	6.18819e-25 (rank : 25)
Query Neighborhood Hits	162	Target Neighborhood Hits	240	Shared Neighborhood Hits	45
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

RADI_HUMAN
NC score	0.692467 (rank : 28)	θ value	2.96777e-27 (rank : 17)
Query Neighborhood Hits	162	Target Neighborhood Hits	741	Shared Neighborhood Hits	51
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
NC score	0.688322 (rank : 29)	θ value	2.96777e-27 (rank : 18)
Query Neighborhood Hits	162	Target Neighborhood Hits	773	Shared Neighborhood Hits	50
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

FARP2_MOUSE
NC score	0.683992 (rank : 30)	θ value	1.05554e-24 (rank : 26)
Query Neighborhood Hits	162	Target Neighborhood Hits	209	Shared Neighborhood Hits	44
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MOES_HUMAN
NC score	0.652510 (rank : 31)	θ value	4.28545e-26 (rank : 20)
Query Neighborhood Hits	162	Target Neighborhood Hits	892	Shared Neighborhood Hits	54
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
NC score	0.644933 (rank : 32)	θ value	2.12685e-25 (rank : 24)
Query Neighborhood Hits	162	Target Neighborhood Hits	923	Shared Neighborhood Hits	55
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

PTN4_HUMAN
NC score	0.603077 (rank : 33)	θ value	2.19584e-30 (rank : 3)
Query Neighborhood Hits	162	Target Neighborhood Hits	303	Shared Neighborhood Hits	49
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

FRMD1_HUMAN
NC score	0.595463 (rank : 34)	θ value	1.17247e-07 (rank : 49)
Query Neighborhood Hits	162	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

PTN3_HUMAN
NC score	0.587294 (rank : 35)	θ value	1.4233e-29 (rank : 4)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	48
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN21_MOUSE
NC score	0.571550 (rank : 36)	θ value	1.33526e-19 (rank : 34)
Query Neighborhood Hits	162	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN21_HUMAN
NC score	0.570568 (rank : 37)	θ value	7.0802e-21 (rank : 33)
Query Neighborhood Hits	162	Target Neighborhood Hits	143	Shared Neighborhood Hits	46
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN14_MOUSE
NC score	0.561370 (rank : 38)	θ value	2.20094e-22 (rank : 31)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

FRMD6_MOUSE
NC score	0.555870 (rank : 39)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	162	Target Neighborhood Hits	63	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

PTN14_HUMAN
NC score	0.553777 (rank : 40)	θ value	5.42112e-21 (rank : 32)
Query Neighborhood Hits	162	Target Neighborhood Hits	163	Shared Neighborhood Hits	45
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

FRMD6_HUMAN
NC score	0.549963 (rank : 41)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	162	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

PTN13_MOUSE
NC score	0.432051 (rank : 42)	θ value	4.30538e-10 (rank : 43)
Query Neighborhood Hits	162	Target Neighborhood Hits	426	Shared Neighborhood Hits	50
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN13_HUMAN
NC score	0.420818 (rank : 43)	θ value	2.36244e-08 (rank : 48)
Query Neighborhood Hits	162	Target Neighborhood Hits	471	Shared Neighborhood Hits	49
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

TLN1_HUMAN
NC score	0.357762 (rank : 44)	θ value	0.0148317 (rank : 68)
Query Neighborhood Hits	162	Target Neighborhood Hits	218	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
NC score	0.353531 (rank : 45)	θ value	0.0330416 (rank : 75)
Query Neighborhood Hits	162	Target Neighborhood Hits	213	Shared Neighborhood Hits	46
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TLN2_MOUSE
NC score	0.346572 (rank : 46)	θ value	0.0193708 (rank : 69)
Query Neighborhood Hits	162	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TLN2_HUMAN
NC score	0.341566 (rank : 47)	θ value	0.0330416 (rank : 76)
Query Neighborhood Hits	162	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

BIRC8_HUMAN
NC score	0.319650 (rank : 48)	θ value	2.13673e-09 (rank : 44)
Query Neighborhood Hits	162	Target Neighborhood Hits	121	Shared Neighborhood Hits	71
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC7_HUMAN
NC score	0.307618 (rank : 49)	θ value	1.80886e-08 (rank : 47)
Query Neighborhood Hits	162	Target Neighborhood Hits	185	Shared Neighborhood Hits	86
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC3_MOUSE
NC score	0.307294 (rank : 50)	θ value	1.74796e-11 (rank : 39)
Query Neighborhood Hits	162	Target Neighborhood Hits	113	Shared Neighborhood Hits	73
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC3_HUMAN
NC score	0.299377 (rank : 51)	θ value	2.98157e-11 (rank : 40)
Query Neighborhood Hits	162	Target Neighborhood Hits	133	Shared Neighborhood Hits	74
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC2_MOUSE
NC score	0.296838 (rank : 52)	θ value	3.89403e-11 (rank : 41)
Query Neighborhood Hits	162	Target Neighborhood Hits	137	Shared Neighborhood Hits	76
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC2_HUMAN
NC score	0.295955 (rank : 53)	θ value	5.08577e-11 (rank : 42)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	75
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

RNF34_HUMAN
NC score	0.284017 (rank : 54)	θ value	1.09739e-05 (rank : 54)
Query Neighborhood Hits	162	Target Neighborhood Hits	153	Shared Neighborhood Hits	72
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

BIRC4_HUMAN
NC score	0.282802 (rank : 55)	θ value	3.64472e-09 (rank : 45)
Query Neighborhood Hits	162	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

RNF34_MOUSE
NC score	0.281894 (rank : 56)	θ value	1.09739e-05 (rank : 55)
Query Neighborhood Hits	162	Target Neighborhood Hits	160	Shared Neighborhood Hits	71
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RFFL_MOUSE
NC score	0.280888 (rank : 57)	θ value	8.40245e-06 (rank : 53)
Query Neighborhood Hits	162	Target Neighborhood Hits	145	Shared Neighborhood Hits	68
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

BIRC4_MOUSE
NC score	0.280559 (rank : 58)	θ value	3.64472e-09 (rank : 46)
Query Neighborhood Hits	162	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

RFFL_HUMAN
NC score	0.277191 (rank : 59)	θ value	8.40245e-06 (rank : 52)
Query Neighborhood Hits	162	Target Neighborhood Hits	175	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RNF26_HUMAN
NC score	0.245675 (rank : 60)	θ value	0.0148317 (rank : 67)
Query Neighborhood Hits	162	Target Neighborhood Hits	95	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

RKHD1_HUMAN
NC score	0.243832 (rank : 61)	θ value	0.000158464 (rank : 59)
Query Neighborhood Hits	162	Target Neighborhood Hits	163	Shared Neighborhood Hits	62
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

CGRF1_HUMAN
NC score	0.231318 (rank : 62)	θ value	0.000270298 (rank : 60)
Query Neighborhood Hits	162	Target Neighborhood Hits	51	Shared Neighborhood Hits	40
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_MOUSE
NC score	0.220542 (rank : 63)	θ value	0.00134147 (rank : 63)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

NEURL_MOUSE
NC score	0.194283 (rank : 64)	θ value	0.00665767 (rank : 65)
Query Neighborhood Hits	162	Target Neighborhood Hits	106	Shared Neighborhood Hits	65
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
NC score	0.189891 (rank : 65)	θ value	0.0148317 (rank : 66)
Query Neighborhood Hits	162	Target Neighborhood Hits	114	Shared Neighborhood Hits	66
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

MGRN1_MOUSE
NC score	0.164349 (rank : 66)	θ value	0.0736092 (rank : 81)
Query Neighborhood Hits	162	Target Neighborhood Hits	149	Shared Neighborhood Hits	66
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MGRN1_HUMAN
NC score	0.160392 (rank : 67)	θ value	0.0736092 (rank : 80)
Query Neighborhood Hits	162	Target Neighborhood Hits	192	Shared Neighborhood Hits	66
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

PEX10_HUMAN
NC score	0.152402 (rank : 68)	θ value	0.00102713 (rank : 62)
Query Neighborhood Hits	162	Target Neighborhood Hits	255	Shared Neighborhood Hits	83
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

LRSM1_MOUSE
NC score	0.141823 (rank : 69)	θ value	4.45536e-07 (rank : 50)
Query Neighborhood Hits	162	Target Neighborhood Hits	874	Shared Neighborhood Hits	70
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

CBLC_MOUSE
NC score	0.139119 (rank : 70)	θ value	0.0330416 (rank : 74)
Query Neighborhood Hits	162	Target Neighborhood Hits	186	Shared Neighborhood Hits	73
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

LRSM1_HUMAN
NC score	0.135985 (rank : 71)	θ value	9.92553e-07 (rank : 51)
Query Neighborhood Hits	162	Target Neighborhood Hits	1078	Shared Neighborhood Hits	70
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

CBLC_HUMAN
NC score	0.131295 (rank : 72)	θ value	0.125558 (rank : 84)
Query Neighborhood Hits	162	Target Neighborhood Hits	173	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

CBLB_MOUSE
NC score	0.131053 (rank : 73)	θ value	0.0330416 (rank : 73)
Query Neighborhood Hits	162	Target Neighborhood Hits	277	Shared Neighborhood Hits	78
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBLB_HUMAN
NC score	0.130853 (rank : 74)	θ value	0.0330416 (rank : 72)
Query Neighborhood Hits	162	Target Neighborhood Hits	261	Shared Neighborhood Hits	78
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBL_HUMAN
NC score	0.130500 (rank : 75)	θ value	0.0431538 (rank : 77)
Query Neighborhood Hits	162	Target Neighborhood Hits	353	Shared Neighborhood Hits	80
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
NC score	0.127516 (rank : 76)	θ value	0.0431538 (rank : 78)
Query Neighborhood Hits	162	Target Neighborhood Hits	426	Shared Neighborhood Hits	81
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

PTN2_MOUSE
NC score	0.111218 (rank : 77)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	162	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN1_MOUSE
NC score	0.110549 (rank : 78)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	162	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN1_HUMAN
NC score	0.110209 (rank : 79)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	162	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN18_HUMAN
NC score	0.110136 (rank : 80)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	162	Target Neighborhood Hits	73	Shared Neighborhood Hits	8
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN2_HUMAN
NC score	0.110062 (rank : 81)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	162	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

MIB1_MOUSE
NC score	0.107450 (rank : 82)	θ value	2.44474e-05 (rank : 56)
Query Neighborhood Hits	162	Target Neighborhood Hits	471	Shared Neighborhood Hits	73
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

PTN9_HUMAN
NC score	0.106934 (rank : 83)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	162	Target Neighborhood Hits	79	Shared Neighborhood Hits	8
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN18_MOUSE
NC score	0.106758 (rank : 84)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	162	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN9_MOUSE
NC score	0.106598 (rank : 85)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	162	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

MIB1_HUMAN
NC score	0.105910 (rank : 86)	θ value	5.44631e-05 (rank : 57)
Query Neighborhood Hits	162	Target Neighborhood Hits	470	Shared Neighborhood Hits	73
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

PTN22_HUMAN
NC score	0.103577 (rank : 87)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	162	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN7_MOUSE
NC score	0.102903 (rank : 88)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	162	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

MIB2_HUMAN
NC score	0.102155 (rank : 89)	θ value	0.000270298 (rank : 61)
Query Neighborhood Hits	162	Target Neighborhood Hits	438	Shared Neighborhood Hits	64
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

PTN22_MOUSE
NC score	0.102143 (rank : 90)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	162	Target Neighborhood Hits	179	Shared Neighborhood Hits	10
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN7_HUMAN
NC score	0.101775 (rank : 91)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	162	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN6_HUMAN
NC score	0.101594 (rank : 92)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	162	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
NC score	0.101567 (rank : 93)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	162	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RN168_HUMAN
NC score	0.101523 (rank : 94)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	162	Target Neighborhood Hits	370	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

PTN12_HUMAN
NC score	0.101513 (rank : 95)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	162	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
NC score	0.101217 (rank : 96)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	162	Target Neighborhood Hits	123	Shared Neighborhood Hits	8
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

BIRC5_MOUSE
NC score	0.100410 (rank : 97)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	162	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

RNF8_MOUSE
NC score	0.099918 (rank : 98)	θ value	0.365318 (rank : 93)
Query Neighborhood Hits	162	Target Neighborhood Hits	618	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

PTPRO_HUMAN
NC score	0.099371 (rank : 99)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	162	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

KRIT1_HUMAN
NC score	0.099343 (rank : 100)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

PTPRN_HUMAN
NC score	0.099174 (rank : 101)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	162	Target Neighborhood Hits	156	Shared Neighborhood Hits	10
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPR2_MOUSE
NC score	0.098898 (rank : 102)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	162	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

MIB2_MOUSE
NC score	0.098799 (rank : 103)	θ value	0.000121331 (rank : 58)
Query Neighborhood Hits	162	Target Neighborhood Hits	409	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

PTPR2_HUMAN
NC score	0.098778 (rank : 104)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	162	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPRN_MOUSE
NC score	0.098639 (rank : 105)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	162	Target Neighborhood Hits	240	Shared Neighborhood Hits	9
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRR_MOUSE
NC score	0.097708 (rank : 106)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	162	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRR_HUMAN
NC score	0.097204 (rank : 107)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	162	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

CD45_MOUSE
NC score	0.096560 (rank : 108)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	162	Target Neighborhood Hits	178	Shared Neighborhood Hits	12
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

PTN5_MOUSE
NC score	0.095761 (rank : 109)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	162	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_HUMAN
NC score	0.095655 (rank : 110)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	162	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTPRJ_MOUSE
NC score	0.095623 (rank : 111)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	162	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTN11_MOUSE
NC score	0.095196 (rank : 112)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	162	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.095192 (rank : 113)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	162	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTPRJ_HUMAN
NC score	0.094960 (rank : 114)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	162	Target Neighborhood Hits	207	Shared Neighborhood Hits	8
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRV_MOUSE
NC score	0.094692 (rank : 115)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	162	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTN23_HUMAN
NC score	0.094035 (rank : 116)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	162	Target Neighborhood Hits	646	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

BIRC5_HUMAN
NC score	0.093837 (rank : 117)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	162	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

PTPRB_HUMAN
NC score	0.093014 (rank : 118)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	162	Target Neighborhood Hits	242	Shared Neighborhood Hits	8
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTN23_MOUSE
NC score	0.092966 (rank : 119)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	162	Target Neighborhood Hits	726	Shared Neighborhood Hits	14
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

KRIT1_MOUSE
NC score	0.092951 (rank : 120)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

CD45_HUMAN
NC score	0.092765 (rank : 121)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	162	Target Neighborhood Hits	243	Shared Neighborhood Hits	10
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CA106_HUMAN
NC score	0.091627 (rank : 122)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	162	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CA106_MOUSE
NC score	0.090115 (rank : 123)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	162	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

PTPRA_HUMAN
NC score	0.089046 (rank : 124)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	162	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRE_HUMAN
NC score	0.089042 (rank : 125)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	162	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_MOUSE
NC score	0.089035 (rank : 126)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	162	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

UHRF2_MOUSE
NC score	0.088795 (rank : 127)	θ value	0.0431538 (rank : 79)
Query Neighborhood Hits	162	Target Neighborhood Hits	275	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

PTPRE_MOUSE
NC score	0.088500 (rank : 128)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	162	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

RNF8_HUMAN
NC score	0.088462 (rank : 129)	θ value	1.38821 (rank : 109)
Query Neighborhood Hits	162	Target Neighborhood Hits	622	Shared Neighborhood Hits	89
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

UHRF1_MOUSE
NC score	0.086306 (rank : 130)	θ value	0.00509761 (rank : 64)
Query Neighborhood Hits	162	Target Neighborhood Hits	278	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

UHRF2_HUMAN
NC score	0.085838 (rank : 131)	θ value	0.0736092 (rank : 82)
Query Neighborhood Hits	162	Target Neighborhood Hits	269	Shared Neighborhood Hits	58
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

TRI26_MOUSE
NC score	0.085629 (rank : 132)	θ value	0.47712 (rank : 95)
Query Neighborhood Hits	162	Target Neighborhood Hits	339	Shared Neighborhood Hits	97
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

RN168_MOUSE
NC score	0.085543 (rank : 133)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	162	Target Neighborhood Hits	440	Shared Neighborhood Hits	83
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN169_HUMAN
NC score	0.084552 (rank : 134)	θ value	0.813845 (rank : 103)
Query Neighborhood Hits	162	Target Neighborhood Hits	203	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

TRI26_HUMAN
NC score	0.084189 (rank : 135)	θ value	0.813845 (rank : 104)
Query Neighborhood Hits	162	Target Neighborhood Hits	335	Shared Neighborhood Hits	94
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI35_MOUSE
NC score	0.083900 (rank : 136)	θ value	0.0193708 (rank : 70)
Query Neighborhood Hits	162	Target Neighborhood Hits	465	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

BIRC1_HUMAN
NC score	0.083342 (rank : 137)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	162	Target Neighborhood Hits	61	Shared Neighborhood Hits	8
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1B_MOUSE
NC score	0.082809 (rank : 138)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	162	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1E_MOUSE
NC score	0.082779 (rank : 139)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	162	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
NC score	0.082473 (rank : 140)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	162	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
NC score	0.082387 (rank : 141)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	162	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1A_MOUSE
NC score	0.081091 (rank : 142)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	162	Target Neighborhood Hits	94	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

TRI35_HUMAN
NC score	0.080725 (rank : 143)	θ value	0.0252991 (rank : 71)
Query Neighborhood Hits	162	Target Neighborhood Hits	382	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

TRI31_HUMAN
NC score	0.080227 (rank : 144)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	162	Target Neighborhood Hits	299	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

MDM4_HUMAN
NC score	0.080201 (rank : 145)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	162	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

TRI37_MOUSE
NC score	0.080159 (rank : 146)	θ value	0.125558 (rank : 87)
Query Neighborhood Hits	162	Target Neighborhood Hits	316	Shared Neighborhood Hits	60
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

RN185_HUMAN
NC score	0.080158 (rank : 147)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	162	Target Neighborhood Hits	213	Shared Neighborhood Hits	74
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

PTPRK_MOUSE
NC score	0.080069 (rank : 148)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	162	Target Neighborhood Hits	223	Shared Neighborhood Hits	8
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRZ_HUMAN
NC score	0.079626 (rank : 149)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	162	Target Neighborhood Hits	255	Shared Neighborhood Hits	9
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

RN185_MOUSE
NC score	0.079542 (rank : 150)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	162	Target Neighborhood Hits	211	Shared Neighborhood Hits	74
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

PTPRK_HUMAN
NC score	0.079405 (rank : 151)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	162	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

TRI37_HUMAN
NC score	0.079268 (rank : 152)	θ value	0.125558 (rank : 86)
Query Neighborhood Hits	162	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

PTPRG_MOUSE
NC score	0.079093 (rank : 153)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	162	Target Neighborhood Hits	260	Shared Neighborhood Hits	9
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_HUMAN
NC score	0.078863 (rank : 154)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	162	Target Neighborhood Hits	231	Shared Neighborhood Hits	8
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

TRI12_MOUSE
NC score	0.077320 (rank : 155)	θ value	0.21417 (rank : 91)
Query Neighborhood Hits	162	Target Neighborhood Hits	387	Shared Neighborhood Hits	79
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

ZC3H5_MOUSE
NC score	0.076769 (rank : 156)	θ value	0.0961366 (rank : 83)
Query Neighborhood Hits	162	Target Neighborhood Hits	136	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

RO52_HUMAN
NC score	0.076726 (rank : 157)	θ value	0.21417 (rank : 90)
Query Neighborhood Hits	162	Target Neighborhood Hits	419	Shared Neighborhood Hits	92
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

PTPRT_HUMAN
NC score	0.076673 (rank : 158)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	162	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
NC score	0.076632 (rank : 159)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	162	Target Neighborhood Hits	219	Shared Neighborhood Hits	8
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

MDM2_HUMAN
NC score	0.075786 (rank : 160)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	162	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

PTPRM_MOUSE
NC score	0.074970 (rank : 161)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	162	Target Neighborhood Hits	238	Shared Neighborhood Hits	8
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRU_HUMAN
NC score	0.074815 (rank : 162)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	162	Target Neighborhood Hits	237	Shared Neighborhood Hits	8
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRM_HUMAN
NC score	0.074550 (rank : 163)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	162	Target Neighborhood Hits	244	Shared Neighborhood Hits	8
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

TRIM2_HUMAN
NC score	0.073780 (rank : 164)	θ value	0.163984 (rank : 88)
Query Neighborhood Hits	162	Target Neighborhood Hits	330	Shared Neighborhood Hits	76
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRI73_HUMAN
NC score	0.073751 (rank : 165)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	84
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

TRI50_MOUSE
NC score	0.073175 (rank : 166)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	162	Target Neighborhood Hits	326	Shared Neighborhood Hits	98
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRI32_MOUSE
NC score	0.073147 (rank : 167)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	162	Target Neighborhood Hits	271	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

RNF5_HUMAN
NC score	0.072928 (rank : 168)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	162	Target Neighborhood Hits	206	Shared Neighborhood Hits	80
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

TRIM2_MOUSE
NC score	0.072799 (rank : 169)	θ value	0.21417 (rank : 92)
Query Neighborhood Hits	162	Target Neighborhood Hits	331	Shared Neighborhood Hits	76
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

ZC3H5_HUMAN
NC score	0.072662 (rank : 170)	θ value	0.47712 (rank : 97)
Query Neighborhood Hits	162	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

RNF5_MOUSE
NC score	0.071995 (rank : 171)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	162	Target Neighborhood Hits	206	Shared Neighborhood Hits	80
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

TRI56_HUMAN
NC score	0.071879 (rank : 172)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	162	Target Neighborhood Hits	339	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

UHRF1_HUMAN
NC score	0.071175 (rank : 173)	θ value	0.62314 (rank : 99)
Query Neighborhood Hits	162	Target Neighborhood Hits	272	Shared Neighborhood Hits	59
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

RO52_MOUSE
NC score	0.070725 (rank : 174)	θ value	1.06291 (rank : 108)
Query Neighborhood Hits	162	Target Neighborhood Hits	360	Shared Neighborhood Hits	87
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

TRI56_MOUSE
NC score	0.069973 (rank : 175)	θ value	1.38821 (rank : 113)
Query Neighborhood Hits	162	Target Neighborhood Hits	255	Shared Neighborhood Hits	69
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

TRI50_HUMAN
NC score	0.069873 (rank : 176)	θ value	0.813845 (rank : 105)
Query Neighborhood Hits	162	Target Neighborhood Hits	294	Shared Neighborhood Hits	92
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRI74_HUMAN
NC score	0.068949 (rank : 177)	θ value	6.88961 (rank : 150)
Query Neighborhood Hits	162	Target Neighborhood Hits	249	Shared Neighborhood Hits	81
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

TRI65_MOUSE
NC score	0.068694 (rank : 178)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	162	Target Neighborhood Hits	340	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

RN123_MOUSE
NC score	0.067904 (rank : 179)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	162	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRI40_HUMAN
NC score	0.067700 (rank : 180)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	162	Target Neighborhood Hits	279	Shared Neighborhood Hits	81
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI32_HUMAN
NC score	0.067558 (rank : 181)	θ value	1.81305 (rank : 118)
Query Neighborhood Hits	162	Target Neighborhood Hits	264	Shared Neighborhood Hits	64
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

LNX2_HUMAN
NC score	0.064940 (rank : 182)	θ value	0.125558 (rank : 85)
Query Neighborhood Hits	162	Target Neighborhood Hits	389	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

RN123_HUMAN
NC score	0.064782 (rank : 183)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	162	Target Neighborhood Hits	175	Shared Neighborhood Hits	58
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

ZN313_MOUSE
NC score	0.064553 (rank : 184)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	162	Target Neighborhood Hits	273	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

TRI39_HUMAN
NC score	0.063903 (rank : 185)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	162	Target Neighborhood Hits	693	Shared Neighborhood Hits	93
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI27_MOUSE
NC score	0.063735 (rank : 186)	θ value	0.47712 (rank : 96)
Query Neighborhood Hits	162	Target Neighborhood Hits	261	Shared Neighborhood Hits	90
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRI17_MOUSE
NC score	0.063007 (rank : 187)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	162	Target Neighborhood Hits	620	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

TRI65_HUMAN
NC score	0.062447 (rank : 188)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	162	Target Neighborhood Hits	330	Shared Neighborhood Hits	78
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

PTPRS_HUMAN
NC score	0.062398 (rank : 189)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	162	Target Neighborhood Hits	472	Shared Neighborhood Hits	11
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

TRI39_MOUSE
NC score	0.061842 (rank : 190)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	162	Target Neighborhood Hits	691	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRIM3_HUMAN
NC score	0.061799 (rank : 191)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	162	Target Neighborhood Hits	357	Shared Neighborhood Hits	75
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

SIAH2_MOUSE
NC score	0.061749 (rank : 192)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	162	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

ZN313_HUMAN
NC score	0.061684 (rank : 193)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	162	Target Neighborhood Hits	264	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

SIAH2_HUMAN
NC score	0.061271 (rank : 194)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	162	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

BIRC6_HUMAN
NC score	0.061224 (rank : 195)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	162	Target Neighborhood Hits	161	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

PTPRD_HUMAN
NC score	0.060958 (rank : 196)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	162	Target Neighborhood Hits	485	Shared Neighborhood Hits	10
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

TRI52_HUMAN
NC score	0.060735 (rank : 197)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	162	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TRI25_MOUSE
NC score	0.060324 (rank : 198)	θ value	5.27518 (rank : 137)
Query Neighborhood Hits	162	Target Neighborhood Hits	446	Shared Neighborhood Hits	80
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

LNX2_MOUSE
NC score	0.060007 (rank : 199)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	162	Target Neighborhood Hits	407	Shared Neighborhood Hits	68
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

RN125_HUMAN
NC score	0.059311 (rank : 200)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	162	Target Neighborhood Hits	230	Shared Neighborhood Hits	71
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

PTPRF_HUMAN
NC score	0.059181 (rank : 201)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	162	Target Neighborhood Hits	489	Shared Neighborhood Hits	8
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

TRIM3_MOUSE
NC score	0.059095 (rank : 202)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	162	Target Neighborhood Hits	351	Shared Neighborhood Hits	69
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRI60_HUMAN
NC score	0.059006 (rank : 203)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	162	Target Neighborhood Hits	357	Shared Neighborhood Hits	89
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

CHFR_HUMAN
NC score	0.058967 (rank : 204)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	162	Target Neighborhood Hits	255	Shared Neighborhood Hits	69
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

TRI27_HUMAN
NC score	0.058667 (rank : 205)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	162	Target Neighborhood Hits	273	Shared Neighborhood Hits	86
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

PTPRD_MOUSE
NC score	0.058540 (rank : 206)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	162	Target Neighborhood Hits	491	Shared Neighborhood Hits	9
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

TRIM5_HUMAN
NC score	0.058165 (rank : 207)	θ value	5.27518 (rank : 139)
Query Neighborhood Hits	162	Target Neighborhood Hits	424	Shared Neighborhood Hits	81
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

TRIM8_HUMAN
NC score	0.057664 (rank : 208)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	162	Target Neighborhood Hits	650	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

RN141_HUMAN
NC score	0.057184 (rank : 209)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	162	Target Neighborhood Hits	199	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_MOUSE
NC score	0.057036 (rank : 210)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	162	Target Neighborhood Hits	200	Shared Neighborhood Hits	58
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

CHFR_MOUSE
NC score	0.056851 (rank : 211)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	162	Target Neighborhood Hits	264	Shared Neighborhood Hits	71
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

TRIM8_MOUSE
NC score	0.056746 (rank : 212)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	162	Target Neighborhood Hits	674	Shared Neighborhood Hits	69
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

FGD5_HUMAN
NC score	0.056126 (rank : 213)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	162	Target Neighborhood Hits	235	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

TRI43_HUMAN
NC score	0.056077 (rank : 214)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	162	Target Neighborhood Hits	341	Shared Neighborhood Hits	83
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

BRCA1_MOUSE
NC score	0.054975 (rank : 215)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	162	Target Neighborhood Hits	436	Shared Neighborhood Hits	79
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

TRIM4_HUMAN
NC score	0.054895 (rank : 216)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	162	Target Neighborhood Hits	321	Shared Neighborhood Hits	83
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

TRI11_HUMAN
NC score	0.054532 (rank : 217)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	162	Target Neighborhood Hits	316	Shared Neighborhood Hits	85
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI11_MOUSE
NC score	0.054453 (rank : 218)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	162	Target Neighborhood Hits	329	Shared Neighborhood Hits	84
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI17_HUMAN
NC score	0.054438 (rank : 219)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	162	Target Neighborhood Hits	318	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

RN125_MOUSE
NC score	0.053652 (rank : 220)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	162	Target Neighborhood Hits	220	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

SIA1B_MOUSE
NC score	0.053531 (rank : 221)	θ value	6.88961 (rank : 145)
Query Neighborhood Hits	162	Target Neighborhood Hits	69	Shared Neighborhood Hits	33
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

TRI30_MOUSE
NC score	0.053232 (rank : 222)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	162	Target Neighborhood Hits	434	Shared Neighborhood Hits	74
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

PML_HUMAN
NC score	0.053105 (rank : 223)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	162	Target Neighborhood Hits	248	Shared Neighborhood Hits	54
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

FGD5_MOUSE
NC score	0.053086 (rank : 224)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	162	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

SIAH1_HUMAN
NC score	0.053001 (rank : 225)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	162	Target Neighborhood Hits	72	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

SIA1A_MOUSE
NC score	0.052754 (rank : 226)	θ value	6.88961 (rank : 144)
Query Neighborhood Hits	162	Target Neighborhood Hits	72	Shared Neighborhood Hits	33
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

HIP1_HUMAN
NC score	0.052634 (rank : 227)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	162	Target Neighborhood Hits	1016	Shared Neighborhood Hits	29
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

FGD6_HUMAN
NC score	0.052599 (rank : 228)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	162	Target Neighborhood Hits	237	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

TRI25_HUMAN
NC score	0.052425 (rank : 229)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	162	Target Neighborhood Hits	472	Shared Neighborhood Hits	80
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

FGD6_MOUSE
NC score	0.052254 (rank : 230)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	162	Target Neighborhood Hits	282	Shared Neighborhood Hits	4
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

TRI22_HUMAN
NC score	0.051695 (rank : 231)	θ value	5.27518 (rank : 136)
Query Neighborhood Hits	162	Target Neighborhood Hits	396	Shared Neighborhood Hits	71
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

BFAR_MOUSE
NC score	0.051672 (rank : 232)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	162	Target Neighborhood Hits	232	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

MDM2_MOUSE
NC score	0.051369 (rank : 233)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	162	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

TRI59_MOUSE
NC score	0.051369 (rank : 234)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	162	Target Neighborhood Hits	292	Shared Neighborhood Hits	70
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

LNX1_MOUSE
NC score	0.051311 (rank : 235)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	162	Target Neighborhood Hits	377	Shared Neighborhood Hits	66
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

TRI68_MOUSE
NC score	0.051059 (rank : 236)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	162	Target Neighborhood Hits	356	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

FGD4_MOUSE
NC score	0.051020 (rank : 237)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	162	Target Neighborhood Hits	227	Shared Neighborhood Hits	4
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

TRI13_MOUSE
NC score	0.050702 (rank : 238)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	162	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

FGD4_HUMAN
NC score	0.050685 (rank : 239)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	162	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

TRI34_HUMAN
NC score	0.050478 (rank : 240)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	162	Target Neighborhood Hits	416	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

CCD50_HUMAN
NC score	0.050429 (rank : 241)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	162	Target Neighborhood Hits	237	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IVM0, Q86VH7	Gene names	CCDC50, C3orf6
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

BFAR_HUMAN
NC score	0.050317 (rank : 242)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	162	Target Neighborhood Hits	222	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

TRI34_MOUSE
NC score	0.050260 (rank : 243)	θ value	5.27518 (rank : 138)
Query Neighborhood Hits	162	Target Neighborhood Hits	332	Shared Neighborhood Hits	64
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

BRCA1_HUMAN
NC score	0.050229 (rank : 244)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	162	Target Neighborhood Hits	381	Shared Neighborhood Hits	77
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

TRIM6_MOUSE
NC score	0.050169 (rank : 245)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	162	Target Neighborhood Hits	451	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

TRI15_HUMAN
NC score	0.050098 (rank : 246)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	162	Target Neighborhood Hits	395	Shared Neighborhood Hits	70
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

LNX1_HUMAN
NC score	0.049117 (rank : 247)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	162	Target Neighborhood Hits	379	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

AMFR2_HUMAN
NC score	0.048099 (rank : 248)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	162	Target Neighborhood Hits	219	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

AMFR_MOUSE
NC score	0.047699 (rank : 249)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	162	Target Neighborhood Hits	208	Shared Neighborhood Hits	60
SwissProt Accessions	Q9R049, Q8K008, Q99LH5	Gene names	Amfr
Domain Architecture
Description	Autocrine motility factor receptor (EC 6.3.2.19) (AMF receptor).

BRE1B_MOUSE
NC score	0.045451 (rank : 250)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	162	Target Neighborhood Hits	970	Shared Neighborhood Hits	67
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

TRI42_HUMAN
NC score	0.044832 (rank : 251)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	162	Target Neighborhood Hits	283	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

RFWD2_MOUSE
NC score	0.043408 (rank : 252)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	162	Target Neighborhood Hits	535	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

BRE1B_HUMAN
NC score	0.043404 (rank : 253)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	162	Target Neighborhood Hits	1040	Shared Neighborhood Hits	67
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

TRI42_MOUSE
NC score	0.043145 (rank : 254)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	162	Target Neighborhood Hits	316	Shared Neighborhood Hits	57
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

RFWD2_HUMAN
NC score	0.041779 (rank : 255)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	162	Target Neighborhood Hits	518	Shared Neighborhood Hits	76
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

TRI46_HUMAN
NC score	0.041179 (rank : 256)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	162	Target Neighborhood Hits	291	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI46_MOUSE
NC score	0.040850 (rank : 257)	θ value	6.88961 (rank : 149)
Query Neighborhood Hits	162	Target Neighborhood Hits	287	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

MYO10_HUMAN
NC score	0.037187 (rank : 258)	θ value	0.21417 (rank : 89)
Query Neighborhood Hits	162	Target Neighborhood Hits	920	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

TRAF7_MOUSE
NC score	0.033064 (rank : 259)	θ value	0.47712 (rank : 94)
Query Neighborhood Hits	162	Target Neighborhood Hits	470	Shared Neighborhood Hits	65
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TRAF7_HUMAN
NC score	0.032865 (rank : 260)	θ value	0.62314 (rank : 98)
Query Neighborhood Hits	162	Target Neighborhood Hits	482	Shared Neighborhood Hits	65
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

RNF24_MOUSE
NC score	0.028777 (rank : 261)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	162	Target Neighborhood Hits	124	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BGI1	Gene names	Rnf24
Domain Architecture	No domain graphic available
Description	RING finger protein 24.

RNF24_HUMAN
NC score	0.024633 (rank : 262)	θ value	4.03905 (rank : 132)
Query Neighborhood Hits	162	Target Neighborhood Hits	122	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y225, Q9UMH1	Gene names	RNF24
Domain Architecture
Description	RING finger protein 24.

CNOT4_HUMAN
NC score	0.023323 (rank : 263)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	162	Target Neighborhood Hits	207	Shared Neighborhood Hits	23
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

HMDH_MOUSE
NC score	0.022936 (rank : 264)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	162	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

CNOT4_MOUSE
NC score	0.022189 (rank : 265)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	162	Target Neighborhood Hits	277	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CI085_MOUSE
NC score	0.018352 (rank : 266)	θ value	5.27518 (rank : 135)
Query Neighborhood Hits	162	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQ90	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf85 homolog.

KRA93_HUMAN
NC score	0.012862 (rank : 267)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	162	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

MUC5B_HUMAN
NC score	0.012327 (rank : 268)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	162	Target Neighborhood Hits	1020	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

CI085_HUMAN
NC score	0.012142 (rank : 269)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	162	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q96MD7, Q5W0N1, Q5W0N3, Q6PJW9, Q86U95	Gene names	C9orf85
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf85.

KRA98_HUMAN
NC score	0.010790 (rank : 270)	θ value	4.03905 (rank : 131)
Query Neighborhood Hits	162	Target Neighborhood Hits	185	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

TR10B_MOUSE
NC score	0.009667 (rank : 271)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	162	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QZM4, Q9JJL5, Q9JJL6	Gene names	Tnfrsf10b, Dr5, Killer
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (MK).

FRAS1_MOUSE
NC score	0.005329 (rank : 272)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	162	Target Neighborhood Hits	747	Shared Neighborhood Hits	12
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RECQ5_HUMAN
NC score	0.004061 (rank : 273)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	162	Target Neighborhood Hits	390	Shared Neighborhood Hits	4
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

MYCB2_MOUSE
NC score	0.003840 (rank : 274)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	162	Target Neighborhood Hits	307	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

ZNF23_HUMAN
NC score	-0.006562 (rank : 275)	θ value	2.36792 (rank : 128)
Query Neighborhood Hits	162	Target Neighborhood Hits	750	Shared Neighborhood Hits	3
SwissProt Accessions	P17027, Q96IT3, Q9UG42	Gene names	ZNF23, KOX16, ZNF359
Domain Architecture
Description	Zinc finger protein 23 (Zinc finger protein 359) (Zinc finger protein KOX16).