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Network neighborhood for query Sequence : FARP2_HUMAN

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FARP2_HUMAN
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FARP1_HUMAN
θ value	0 (rank : 1)	NC score	0.974867 (rank : 3)
Query Neighborhood Hits	240	Target Neighborhood Hits	241	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	240	Target Neighborhood Hits	240	Shared Neighborhood Hits	240
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	0 (rank : 3)	NC score	0.989644 (rank : 2)
Query Neighborhood Hits	240	Target Neighborhood Hits	209	Shared Neighborhood Hits	164
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PTN4_HUMAN
θ value	3.45727e-76 (rank : 4)	NC score	0.549199 (rank : 38)
Query Neighborhood Hits	240	Target Neighborhood Hits	303	Shared Neighborhood Hits	52
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

E41L3_HUMAN
θ value	1.31681e-67 (rank : 5)	NC score	0.778548 (rank : 4)
Query Neighborhood Hits	240	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	5.00389e-67 (rank : 6)	NC score	0.767503 (rank : 14)
Query Neighborhood Hits	240	Target Neighborhood Hits	250	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L2_HUMAN
θ value	2.10232e-65 (rank : 7)	NC score	0.763105 (rank : 16)
Query Neighborhood Hits	240	Target Neighborhood Hits	287	Shared Neighborhood Hits	51
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

41_HUMAN
θ value	4.68348e-65 (rank : 8)	NC score	0.774002 (rank : 8)
Query Neighborhood Hits	240	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L1_HUMAN
θ value	5.17823e-64 (rank : 9)	NC score	0.769471 (rank : 13)
Query Neighborhood Hits	240	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	1.15359e-63 (rank : 10)	NC score	0.773333 (rank : 9)
Query Neighborhood Hits	240	Target Neighborhood Hits	106	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_MOUSE
θ value	2.56992e-63 (rank : 11)	NC score	0.748099 (rank : 18)
Query Neighborhood Hits	240	Target Neighborhood Hits	459	Shared Neighborhood Hits	57
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

41_MOUSE
θ value	1.11734e-58 (rank : 12)	NC score	0.770658 (rank : 12)
Query Neighborhood Hits	240	Target Neighborhood Hits	184	Shared Neighborhood Hits	52
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L5_HUMAN
θ value	5.73848e-55 (rank : 13)	NC score	0.776713 (rank : 5)
Query Neighborhood Hits	240	Target Neighborhood Hits	76	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
θ value	9.16162e-53 (rank : 14)	NC score	0.776370 (rank : 6)
Query Neighborhood Hits	240	Target Neighborhood Hits	59	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

E41LB_HUMAN
θ value	1.32293e-51 (rank : 15)	NC score	0.772088 (rank : 10)
Query Neighborhood Hits	240	Target Neighborhood Hits	79	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

FGD4_MOUSE
θ value	3.72821e-46 (rank : 16)	NC score	0.565602 (rank : 32)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	94
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
θ value	1.08474e-45 (rank : 17)	NC score	0.565967 (rank : 31)
Query Neighborhood Hits	240	Target Neighborhood Hits	219	Shared Neighborhood Hits	96
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FRMD5_MOUSE
θ value	1.85029e-45 (rank : 18)	NC score	0.774025 (rank : 7)
Query Neighborhood Hits	240	Target Neighborhood Hits	55	Shared Neighborhood Hits	47
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

PTN3_HUMAN
θ value	3.15612e-45 (rank : 19)	NC score	0.524154 (rank : 44)
Query Neighborhood Hits	240	Target Neighborhood Hits	258	Shared Neighborhood Hits	52
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

FRMD5_HUMAN
θ value	9.18288e-45 (rank : 20)	NC score	0.771713 (rank : 11)
Query Neighborhood Hits	240	Target Neighborhood Hits	55	Shared Neighborhood Hits	47
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41LA_HUMAN
θ value	7.27602e-42 (rank : 21)	NC score	0.763844 (rank : 15)
Query Neighborhood Hits	240	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

FGD6_HUMAN
θ value	6.15952e-41 (rank : 22)	NC score	0.542723 (rank : 43)
Query Neighborhood Hits	240	Target Neighborhood Hits	237	Shared Neighborhood Hits	95
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	3.05695e-40 (rank : 23)	NC score	0.546555 (rank : 40)
Query Neighborhood Hits	240	Target Neighborhood Hits	282	Shared Neighborhood Hits	95
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

E41LA_MOUSE
θ value	1.98146e-39 (rank : 24)	NC score	0.761924 (rank : 17)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	48
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

FGD1_HUMAN
θ value	8.32485e-38 (rank : 25)	NC score	0.558136 (rank : 34)
Query Neighborhood Hits	240	Target Neighborhood Hits	367	Shared Neighborhood Hits	101
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	8.32485e-38 (rank : 26)	NC score	0.555124 (rank : 35)
Query Neighborhood Hits	240	Target Neighborhood Hits	387	Shared Neighborhood Hits	96
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RADI_HUMAN
θ value	8.06329e-33 (rank : 27)	NC score	0.594469 (rank : 29)
Query Neighborhood Hits	240	Target Neighborhood Hits	741	Shared Neighborhood Hits	63
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	8.06329e-33 (rank : 28)	NC score	0.590821 (rank : 30)
Query Neighborhood Hits	240	Target Neighborhood Hits	773	Shared Neighborhood Hits	62
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

MOES_MOUSE
θ value	8.91499e-32 (rank : 29)	NC score	0.553109 (rank : 37)
Query Neighborhood Hits	240	Target Neighborhood Hits	923	Shared Neighborhood Hits	68
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_HUMAN
θ value	1.16434e-31 (rank : 30)	NC score	0.559633 (rank : 33)
Query Neighborhood Hits	240	Target Neighborhood Hits	892	Shared Neighborhood Hits	68
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FGD2_MOUSE
θ value	4.42448e-31 (rank : 31)	NC score	0.546418 (rank : 41)
Query Neighborhood Hits	240	Target Neighborhood Hits	163	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD5_HUMAN
θ value	5.77852e-31 (rank : 32)	NC score	0.499008 (rank : 49)
Query Neighborhood Hits	240	Target Neighborhood Hits	235	Shared Neighborhood Hits	72
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

EZRI_MOUSE
θ value	4.89182e-30 (rank : 33)	NC score	0.603611 (rank : 28)
Query Neighborhood Hits	240	Target Neighborhood Hits	693	Shared Neighborhood Hits	60
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_HUMAN
θ value	1.4233e-29 (rank : 34)	NC score	0.606571 (rank : 27)
Query Neighborhood Hits	240	Target Neighborhood Hits	663	Shared Neighborhood Hits	60
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

PTN21_MOUSE
θ value	1.85889e-29 (rank : 35)	NC score	0.499246 (rank : 48)
Query Neighborhood Hits	240	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN21_HUMAN
θ value	2.68423e-28 (rank : 36)	NC score	0.497698 (rank : 50)
Query Neighborhood Hits	240	Target Neighborhood Hits	143	Shared Neighborhood Hits	47
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

MERL_HUMAN
θ value	1.73987e-27 (rank : 37)	NC score	0.635601 (rank : 26)
Query Neighborhood Hits	240	Target Neighborhood Hits	532	Shared Neighborhood Hits	58
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	2.27234e-27 (rank : 38)	NC score	0.636187 (rank : 25)
Query Neighborhood Hits	240	Target Neighborhood Hits	524	Shared Neighborhood Hits	58
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

FGD3_HUMAN
θ value	1.47289e-26 (rank : 39)	NC score	0.545492 (rank : 42)
Query Neighborhood Hits	240	Target Neighborhood Hits	249	Shared Neighborhood Hits	74
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	3.28125e-26 (rank : 40)	NC score	0.553170 (rank : 36)
Query Neighborhood Hits	240	Target Neighborhood Hits	257	Shared Neighborhood Hits	88
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD5_MOUSE
θ value	2.12685e-25 (rank : 41)	NC score	0.489406 (rank : 52)
Query Neighborhood Hits	240	Target Neighborhood Hits	170	Shared Neighborhood Hits	76
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG4_HUMAN
θ value	3.62785e-25 (rank : 42)	NC score	0.477962 (rank : 55)
Query Neighborhood Hits	240	Target Neighborhood Hits	242	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

MYLIP_HUMAN
θ value	6.18819e-25 (rank : 43)	NC score	0.692525 (rank : 20)
Query Neighborhood Hits	240	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	1.37858e-24 (rank : 44)	NC score	0.703668 (rank : 19)
Query Neighborhood Hits	240	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

ARHG4_MOUSE
θ value	1.16704e-23 (rank : 45)	NC score	0.490762 (rank : 51)
Query Neighborhood Hits	240	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD2_HUMAN
θ value	2.59989e-23 (rank : 46)	NC score	0.548710 (rank : 39)
Query Neighborhood Hits	240	Target Neighborhood Hits	151	Shared Neighborhood Hits	82
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

PTN14_MOUSE
θ value	9.87957e-23 (rank : 47)	NC score	0.482198 (rank : 54)
Query Neighborhood Hits	240	Target Neighborhood Hits	142	Shared Neighborhood Hits	47
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN14_HUMAN
θ value	1.42661e-21 (rank : 48)	NC score	0.476238 (rank : 56)
Query Neighborhood Hits	240	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

FRM4A_MOUSE
θ value	1.2077e-20 (rank : 49)	NC score	0.644433 (rank : 23)
Query Neighborhood Hits	240	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4B_HUMAN
θ value	1.5773e-20 (rank : 50)	NC score	0.649467 (rank : 21)
Query Neighborhood Hits	240	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

PREX1_HUMAN
θ value	2.69047e-20 (rank : 51)	NC score	0.507474 (rank : 46)
Query Neighborhood Hits	240	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FRM4A_HUMAN
θ value	3.51386e-20 (rank : 52)	NC score	0.642894 (rank : 24)
Query Neighborhood Hits	240	Target Neighborhood Hits	110	Shared Neighborhood Hits	46
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4B_MOUSE
θ value	7.82807e-20 (rank : 53)	NC score	0.647414 (rank : 22)
Query Neighborhood Hits	240	Target Neighborhood Hits	109	Shared Neighborhood Hits	48
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

PTN13_HUMAN
θ value	2.13179e-17 (rank : 54)	NC score	0.376143 (rank : 71)
Query Neighborhood Hits	240	Target Neighborhood Hits	471	Shared Neighborhood Hits	59
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN13_MOUSE
θ value	4.74913e-17 (rank : 55)	NC score	0.382729 (rank : 70)
Query Neighborhood Hits	240	Target Neighborhood Hits	426	Shared Neighborhood Hits	56
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

ARHG9_HUMAN
θ value	3.07829e-16 (rank : 56)	NC score	0.463146 (rank : 58)
Query Neighborhood Hits	240	Target Neighborhood Hits	235	Shared Neighborhood Hits	69
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	3.07829e-16 (rank : 57)	NC score	0.462183 (rank : 59)
Query Neighborhood Hits	240	Target Neighborhood Hits	234	Shared Neighborhood Hits	69
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PKHG1_HUMAN
θ value	1.16975e-15 (rank : 58)	NC score	0.484203 (rank : 53)
Query Neighborhood Hits	240	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG7_HUMAN
θ value	1.29331e-14 (rank : 59)	NC score	0.375417 (rank : 72)
Query Neighborhood Hits	240	Target Neighborhood Hits	347	Shared Neighborhood Hits	75
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ITSN1_HUMAN
θ value	2.43908e-13 (rank : 60)	NC score	0.272028 (rank : 108)
Query Neighborhood Hits	240	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHG6_MOUSE
θ value	2.0648e-12 (rank : 61)	NC score	0.325338 (rank : 85)
Query Neighborhood Hits	240	Target Neighborhood Hits	394	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ITSN1_MOUSE
θ value	2.69671e-12 (rank : 62)	NC score	0.274357 (rank : 107)
Query Neighborhood Hits	240	Target Neighborhood Hits	1669	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DUET_HUMAN
θ value	3.52202e-12 (rank : 63)	NC score	0.144732 (rank : 132)
Query Neighborhood Hits	240	Target Neighborhood Hits	1220	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
θ value	6.00763e-12 (rank : 64)	NC score	0.142602 (rank : 133)
Query Neighborhood Hits	240	Target Neighborhood Hits	1580	Shared Neighborhood Hits	95
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

GNRP_MOUSE
θ value	1.02475e-11 (rank : 65)	NC score	0.349727 (rank : 79)
Query Neighborhood Hits	240	Target Neighborhood Hits	191	Shared Neighborhood Hits	84
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ITSN2_MOUSE
θ value	1.33837e-11 (rank : 66)	NC score	0.279506 (rank : 104)
Query Neighborhood Hits	240	Target Neighborhood Hits	1371	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN2_HUMAN
θ value	1.74796e-11 (rank : 67)	NC score	0.284977 (rank : 101)
Query Neighborhood Hits	240	Target Neighborhood Hits	1173	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ABR_HUMAN
θ value	5.08577e-11 (rank : 68)	NC score	0.286561 (rank : 99)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG6_HUMAN
θ value	5.08577e-11 (rank : 69)	NC score	0.335442 (rank : 82)
Query Neighborhood Hits	240	Target Neighborhood Hits	376	Shared Neighborhood Hits	65
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG7_MOUSE
θ value	6.64225e-11 (rank : 70)	NC score	0.358665 (rank : 75)
Query Neighborhood Hits	240	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

TIAM1_MOUSE
θ value	1.47974e-10 (rank : 71)	NC score	0.403588 (rank : 65)
Query Neighborhood Hits	240	Target Neighborhood Hits	205	Shared Neighborhood Hits	77
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
θ value	1.9326e-10 (rank : 72)	NC score	0.403819 (rank : 64)
Query Neighborhood Hits	240	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHGG_MOUSE
θ value	5.62301e-10 (rank : 73)	NC score	0.406668 (rank : 63)
Query Neighborhood Hits	240	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG2_MOUSE
θ value	7.34386e-10 (rank : 74)	NC score	0.346830 (rank : 81)
Query Neighborhood Hits	240	Target Neighborhood Hits	120	Shared Neighborhood Hits	58
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGG_HUMAN
θ value	1.25267e-09 (rank : 75)	NC score	0.412503 (rank : 62)
Query Neighborhood Hits	240	Target Neighborhood Hits	129	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DNMBP_MOUSE
θ value	4.76016e-09 (rank : 76)	NC score	0.318374 (rank : 91)
Query Neighborhood Hits	240	Target Neighborhood Hits	435	Shared Neighborhood Hits	69
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PKHA6_MOUSE
θ value	4.76016e-09 (rank : 77)	NC score	0.228420 (rank : 120)
Query Neighborhood Hits	240	Target Neighborhood Hits	591	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
θ value	8.11959e-09 (rank : 78)	NC score	0.219572 (rank : 123)
Query Neighborhood Hits	240	Target Neighborhood Hits	556	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF2_HUMAN
θ value	8.11959e-09 (rank : 79)	NC score	0.324296 (rank : 86)
Query Neighborhood Hits	240	Target Neighborhood Hits	75	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	8.11959e-09 (rank : 80)	NC score	0.323875 (rank : 87)
Query Neighborhood Hits	240	Target Neighborhood Hits	77	Shared Neighborhood Hits	30
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ARHGB_HUMAN
θ value	1.06045e-08 (rank : 81)	NC score	0.333041 (rank : 84)
Query Neighborhood Hits	240	Target Neighborhood Hits	375	Shared Neighborhood Hits	71
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DNMBP_HUMAN
θ value	1.38499e-08 (rank : 82)	NC score	0.303203 (rank : 96)
Query Neighborhood Hits	240	Target Neighborhood Hits	413	Shared Neighborhood Hits	71
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

BCR_HUMAN
θ value	4.0297e-08 (rank : 83)	NC score	0.285152 (rank : 100)
Query Neighborhood Hits	240	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

PKHF1_MOUSE
θ value	4.0297e-08 (rank : 84)	NC score	0.317447 (rank : 92)
Query Neighborhood Hits	240	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

NGEF_MOUSE
θ value	5.26297e-08 (rank : 85)	NC score	0.389207 (rank : 69)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHF1_HUMAN
θ value	6.87365e-08 (rank : 86)	NC score	0.317248 (rank : 93)
Query Neighborhood Hits	240	Target Neighborhood Hits	76	Shared Neighborhood Hits	24
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

SOS1_HUMAN
θ value	6.87365e-08 (rank : 87)	NC score	0.234235 (rank : 119)
Query Neighborhood Hits	240	Target Neighborhood Hits	274	Shared Neighborhood Hits	53
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ARHG5_HUMAN
θ value	1.17247e-07 (rank : 88)	NC score	0.396695 (rank : 66)
Query Neighborhood Hits	240	Target Neighborhood Hits	172	Shared Neighborhood Hits	63
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ECT2_MOUSE
θ value	1.17247e-07 (rank : 89)	NC score	0.446212 (rank : 60)
Query Neighborhood Hits	240	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

NGEF_HUMAN
θ value	1.53129e-07 (rank : 90)	NC score	0.395808 (rank : 67)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHA5_HUMAN
θ value	2.61198e-07 (rank : 91)	NC score	0.173093 (rank : 124)
Query Neighborhood Hits	240	Target Neighborhood Hits	455	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

ECT2_HUMAN
θ value	4.45536e-07 (rank : 92)	NC score	0.437300 (rank : 61)
Query Neighborhood Hits	240	Target Neighborhood Hits	98	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG8_HUMAN
θ value	9.92553e-07 (rank : 93)	NC score	0.346890 (rank : 80)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SOS1_MOUSE
θ value	9.92553e-07 (rank : 94)	NC score	0.221992 (rank : 122)
Query Neighborhood Hits	240	Target Neighborhood Hits	281	Shared Neighborhood Hits	52
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	9.92553e-07 (rank : 95)	NC score	0.225380 (rank : 121)
Query Neighborhood Hits	240	Target Neighborhood Hits	193	Shared Neighborhood Hits	53
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

VAV3_HUMAN
θ value	9.92553e-07 (rank : 96)	NC score	0.260725 (rank : 115)
Query Neighborhood Hits	240	Target Neighborhood Hits	398	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	9.92553e-07 (rank : 97)	NC score	0.264653 (rank : 113)
Query Neighborhood Hits	240	Target Neighborhood Hits	404	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PKHA2_MOUSE
θ value	1.29631e-06 (rank : 98)	NC score	0.164595 (rank : 126)
Query Neighborhood Hits	240	Target Neighborhood Hits	116	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

ARHG8_MOUSE
θ value	1.43324e-05 (rank : 99)	NC score	0.321138 (rank : 88)
Query Neighborhood Hits	240	Target Neighborhood Hits	79	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

MCF2_HUMAN
θ value	1.43324e-05 (rank : 100)	NC score	0.389477 (rank : 68)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MCF2L_MOUSE
θ value	3.19293e-05 (rank : 101)	NC score	0.356290 (rank : 76)
Query Neighborhood Hits	240	Target Neighborhood Hits	255	Shared Neighborhood Hits	68
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

HAPIP_HUMAN
θ value	4.1701e-05 (rank : 102)	NC score	0.350168 (rank : 78)
Query Neighborhood Hits	240	Target Neighborhood Hits	350	Shared Neighborhood Hits	73
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

PKHA2_HUMAN
θ value	4.1701e-05 (rank : 103)	NC score	0.152036 (rank : 130)
Query Neighborhood Hits	240	Target Neighborhood Hits	119	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

ARHGC_HUMAN
θ value	7.1131e-05 (rank : 104)	NC score	0.304955 (rank : 95)
Query Neighborhood Hits	240	Target Neighborhood Hits	351	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PLEK_HUMAN
θ value	0.000158464 (rank : 105)	NC score	0.134279 (rank : 137)
Query Neighborhood Hits	240	Target Neighborhood Hits	110	Shared Neighborhood Hits	44
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

ARHGC_MOUSE
θ value	0.00020696 (rank : 106)	NC score	0.300886 (rank : 97)
Query Neighborhood Hits	240	Target Neighborhood Hits	344	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FRMD6_MOUSE
θ value	0.00020696 (rank : 107)	NC score	0.509111 (rank : 45)
Query Neighborhood Hits	240	Target Neighborhood Hits	63	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

FRMD6_HUMAN
θ value	0.000461057 (rank : 108)	NC score	0.501007 (rank : 47)
Query Neighborhood Hits	240	Target Neighborhood Hits	60	Shared Neighborhood Hits	42
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

RGS3_MOUSE
θ value	0.000461057 (rank : 109)	NC score	0.041003 (rank : 313)
Query Neighborhood Hits	240	Target Neighborhood Hits	1621	Shared Neighborhood Hits	63
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

VAV_MOUSE
θ value	0.000602161 (rank : 110)	NC score	0.268921 (rank : 111)
Query Neighborhood Hits	240	Target Neighborhood Hits	430	Shared Neighborhood Hits	67
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

PLEK_MOUSE
θ value	0.000786445 (rank : 111)	NC score	0.126571 (rank : 138)
Query Neighborhood Hits	240	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RGNEF_MOUSE
θ value	0.000786445 (rank : 112)	NC score	0.265463 (rank : 112)
Query Neighborhood Hits	240	Target Neighborhood Hits	641	Shared Neighborhood Hits	71
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

PKHA4_MOUSE
θ value	0.00102713 (rank : 113)	NC score	0.170540 (rank : 125)
Query Neighborhood Hits	240	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

C43BP_HUMAN
θ value	0.00134147 (rank : 114)	NC score	0.098049 (rank : 149)
Query Neighborhood Hits	240	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	0.00134147 (rank : 115)	NC score	0.099120 (rank : 148)
Query Neighborhood Hits	240	Target Neighborhood Hits	91	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

ARHGA_HUMAN
θ value	0.00175202 (rank : 116)	NC score	0.364562 (rank : 73)
Query Neighborhood Hits	240	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PKHG4_HUMAN
θ value	0.00175202 (rank : 117)	NC score	0.333324 (rank : 83)
Query Neighborhood Hits	240	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PKHA4_HUMAN
θ value	0.00228821 (rank : 118)	NC score	0.159877 (rank : 127)
Query Neighborhood Hits	240	Target Neighborhood Hits	283	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA1_MOUSE
θ value	0.00665767 (rank : 119)	NC score	0.118184 (rank : 139)
Query Neighborhood Hits	240	Target Neighborhood Hits	120	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

VAV_HUMAN
θ value	0.00665767 (rank : 120)	NC score	0.263388 (rank : 114)
Query Neighborhood Hits	240	Target Neighborhood Hits	452	Shared Neighborhood Hits	65
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHGA_MOUSE
θ value	0.0113563 (rank : 121)	NC score	0.360220 (rank : 74)
Query Neighborhood Hits	240	Target Neighborhood Hits	125	Shared Neighborhood Hits	59
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CYH3_MOUSE
θ value	0.0148317 (rank : 122)	NC score	0.096146 (rank : 150)
Query Neighborhood Hits	240	Target Neighborhood Hits	148	Shared Neighborhood Hits	48
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

ZIMP7_MOUSE
θ value	0.0148317 (rank : 123)	NC score	0.030815 (rank : 322)
Query Neighborhood Hits	240	Target Neighborhood Hits	566	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

PKHA1_HUMAN
θ value	0.0252991 (rank : 124)	NC score	0.117259 (rank : 140)
Query Neighborhood Hits	240	Target Neighborhood Hits	127	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ALS2_HUMAN
θ value	0.0330416 (rank : 125)	NC score	0.094352 (rank : 153)
Query Neighborhood Hits	240	Target Neighborhood Hits	121	Shared Neighborhood Hits	27
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

SPTN2_HUMAN
θ value	0.0431538 (rank : 126)	NC score	0.031495 (rank : 321)
Query Neighborhood Hits	240	Target Neighborhood Hits	535	Shared Neighborhood Hits	45
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

CYH3_HUMAN
θ value	0.0736092 (rank : 127)	NC score	0.085267 (rank : 182)
Query Neighborhood Hits	240	Target Neighborhood Hits	137	Shared Neighborhood Hits	41
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

MLL3_HUMAN
θ value	0.0961366 (rank : 128)	NC score	0.030576 (rank : 324)
Query Neighborhood Hits	240	Target Neighborhood Hits	1644	Shared Neighborhood Hits	70
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PCLO_MOUSE
θ value	0.0961366 (rank : 129)	NC score	0.030713 (rank : 323)
Query Neighborhood Hits	240	Target Neighborhood Hits	2275	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CSR2B_HUMAN
θ value	0.163984 (rank : 130)	NC score	0.029484 (rank : 325)
Query Neighborhood Hits	240	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8E8, Q96GW6, Q96IH3, Q9HBF0, Q9UIY5	Gene names	CSRP2BP
Domain Architecture
Description	Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (CRP2BP) (CRP2-binding partner).

TLN1_HUMAN
θ value	0.163984 (rank : 131)	NC score	0.282569 (rank : 102)
Query Neighborhood Hits	240	Target Neighborhood Hits	218	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

CYH2_HUMAN
θ value	0.21417 (rank : 132)	NC score	0.079858 (rank : 208)
Query Neighborhood Hits	240	Target Neighborhood Hits	175	Shared Neighborhood Hits	48
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.21417 (rank : 133)	NC score	0.079853 (rank : 209)
Query Neighborhood Hits	240	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

MLL2_HUMAN
θ value	0.21417 (rank : 134)	NC score	0.027155 (rank : 326)
Query Neighborhood Hits	240	Target Neighborhood Hits	1788	Shared Neighborhood Hits	65
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ARHGF_HUMAN
θ value	0.279714 (rank : 135)	NC score	0.352903 (rank : 77)
Query Neighborhood Hits	240	Target Neighborhood Hits	214	Shared Neighborhood Hits	73
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FOXN1_MOUSE
θ value	0.279714 (rank : 136)	NC score	0.014690 (rank : 348)
Query Neighborhood Hits	240	Target Neighborhood Hits	300	Shared Neighborhood Hits	18
SwissProt Accessions	Q61575	Gene names	Foxn1, Fkh19, Hfh11, Whn
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/forkhead homolog 11) (HFH-11).

K1914_HUMAN
θ value	0.365318 (rank : 137)	NC score	0.060688 (rank : 257)
Query Neighborhood Hits	240	Target Neighborhood Hits	255	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

OSBL9_HUMAN
θ value	0.365318 (rank : 138)	NC score	0.065335 (rank : 246)
Query Neighborhood Hits	240	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

SRRM2_HUMAN
θ value	0.365318 (rank : 139)	NC score	0.031811 (rank : 320)
Query Neighborhood Hits	240	Target Neighborhood Hits	1296	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

IASPP_MOUSE
θ value	0.47712 (rank : 140)	NC score	0.044615 (rank : 308)
Query Neighborhood Hits	240	Target Neighborhood Hits	1024	Shared Neighborhood Hits	54
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TLN1_MOUSE
θ value	0.47712 (rank : 141)	NC score	0.278528 (rank : 105)
Query Neighborhood Hits	240	Target Neighborhood Hits	213	Shared Neighborhood Hits	52
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

APC_HUMAN
θ value	0.62314 (rank : 142)	NC score	0.020534 (rank : 338)
Query Neighborhood Hits	240	Target Neighborhood Hits	603	Shared Neighborhood Hits	26
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

CEND2_HUMAN
θ value	0.62314 (rank : 143)	NC score	0.045568 (rank : 307)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	0.62314 (rank : 144)	NC score	0.042365 (rank : 311)
Query Neighborhood Hits	240	Target Neighborhood Hits	275	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CNKR2_HUMAN
θ value	0.62314 (rank : 145)	NC score	0.100849 (rank : 147)
Query Neighborhood Hits	240	Target Neighborhood Hits	197	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.62314 (rank : 146)	NC score	0.101204 (rank : 146)
Query Neighborhood Hits	240	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CYH4_HUMAN
θ value	0.62314 (rank : 147)	NC score	0.079396 (rank : 211)
Query Neighborhood Hits	240	Target Neighborhood Hits	135	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	0.62314 (rank : 148)	NC score	0.082232 (rank : 197)
Query Neighborhood Hits	240	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

SPTB2_HUMAN
θ value	0.62314 (rank : 149)	NC score	0.035471 (rank : 315)
Query Neighborhood Hits	240	Target Neighborhood Hits	748	Shared Neighborhood Hits	48
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TRIM7_HUMAN
θ value	0.62314 (rank : 150)	NC score	0.004280 (rank : 378)
Query Neighborhood Hits	240	Target Neighborhood Hits	336	Shared Neighborhood Hits	7
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

3BP2_HUMAN
θ value	0.813845 (rank : 151)	NC score	0.092885 (rank : 157)
Query Neighborhood Hits	240	Target Neighborhood Hits	296	Shared Neighborhood Hits	43
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CEND3_MOUSE
θ value	0.813845 (rank : 152)	NC score	0.040281 (rank : 314)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CYH1_HUMAN
θ value	0.813845 (rank : 153)	NC score	0.081093 (rank : 201)
Query Neighborhood Hits	240	Target Neighborhood Hits	184	Shared Neighborhood Hits	53
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.813845 (rank : 154)	NC score	0.078845 (rank : 213)
Query Neighborhood Hits	240	Target Neighborhood Hits	176	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

NCOR2_HUMAN
θ value	0.813845 (rank : 155)	NC score	0.020522 (rank : 339)
Query Neighborhood Hits	240	Target Neighborhood Hits	870	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

3BP2_MOUSE
θ value	1.06291 (rank : 156)	NC score	0.093344 (rank : 156)
Query Neighborhood Hits	240	Target Neighborhood Hits	142	Shared Neighborhood Hits	36
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

BSN_MOUSE
θ value	1.06291 (rank : 157)	NC score	0.033841 (rank : 318)
Query Neighborhood Hits	240	Target Neighborhood Hits	2057	Shared Neighborhood Hits	82
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

DAB1_HUMAN
θ value	1.06291 (rank : 158)	NC score	0.013970 (rank : 350)
Query Neighborhood Hits	240	Target Neighborhood Hits	219	Shared Neighborhood Hits	15
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

RGS3_HUMAN
θ value	1.06291 (rank : 159)	NC score	0.022147 (rank : 334)
Query Neighborhood Hits	240	Target Neighborhood Hits	1375	Shared Neighborhood Hits	47
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SPTB2_MOUSE
θ value	1.06291 (rank : 160)	NC score	0.033972 (rank : 317)
Query Neighborhood Hits	240	Target Neighborhood Hits	770	Shared Neighborhood Hits	52
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TLN2_HUMAN
θ value	1.06291 (rank : 161)	NC score	0.269036 (rank : 110)
Query Neighborhood Hits	240	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

CNKR1_HUMAN
θ value	1.38821 (rank : 162)	NC score	0.112011 (rank : 142)
Query Neighborhood Hits	240	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

STAP2_MOUSE
θ value	1.38821 (rank : 163)	NC score	0.023965 (rank : 328)
Query Neighborhood Hits	240	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

TLN2_MOUSE
θ value	1.38821 (rank : 164)	NC score	0.271712 (rank : 109)
Query Neighborhood Hits	240	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

ACOT2_HUMAN
θ value	1.81305 (rank : 165)	NC score	0.011688 (rank : 353)
Query Neighborhood Hits	240	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	P49753, Q9NUX4	Gene names	ACOT2, PTE2, PTE2A
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2 (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (ZAP128) (CTE-Ia).

DEN1A_MOUSE
θ value	1.81305 (rank : 166)	NC score	0.009375 (rank : 358)
Query Neighborhood Hits	240	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K382	Gene names	Dennd1a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

MEF2D_MOUSE
θ value	1.81305 (rank : 167)	NC score	0.011741 (rank : 352)
Query Neighborhood Hits	240	Target Neighborhood Hits	146	Shared Neighborhood Hits	13
SwissProt Accessions	Q63943, Q63944	Gene names	Mef2d
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

SOX7_HUMAN
θ value	1.81305 (rank : 168)	NC score	0.003581 (rank : 383)
Query Neighborhood Hits	240	Target Neighborhood Hits	140	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BT81	Gene names	SOX7
Domain Architecture
Description	Transcription factor SOX-7.

ZN516_MOUSE
θ value	1.81305 (rank : 169)	NC score	-0.003864 (rank : 396)
Query Neighborhood Hits	240	Target Neighborhood Hits	1197	Shared Neighborhood Hits	31
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

IASPP_HUMAN
θ value	2.36792 (rank : 170)	NC score	0.043234 (rank : 310)
Query Neighborhood Hits	240	Target Neighborhood Hits	688	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

K1914_MOUSE
θ value	2.36792 (rank : 171)	NC score	0.044316 (rank : 309)
Query Neighborhood Hits	240	Target Neighborhood Hits	216	Shared Neighborhood Hits	25
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

MYH8_MOUSE
θ value	2.36792 (rank : 172)	NC score	0.021889 (rank : 335)
Query Neighborhood Hits	240	Target Neighborhood Hits	1600	Shared Neighborhood Hits	51
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

RECQ5_HUMAN
θ value	2.36792 (rank : 173)	NC score	0.007305 (rank : 366)
Query Neighborhood Hits	240	Target Neighborhood Hits	390	Shared Neighborhood Hits	23
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RUFY1_HUMAN
θ value	2.36792 (rank : 174)	NC score	0.084767 (rank : 185)
Query Neighborhood Hits	240	Target Neighborhood Hits	848	Shared Neighborhood Hits	42
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

ULK1_MOUSE
θ value	2.36792 (rank : 175)	NC score	-0.002625 (rank : 394)
Query Neighborhood Hits	240	Target Neighborhood Hits	1214	Shared Neighborhood Hits	27
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

BSN_HUMAN
θ value	3.0926 (rank : 176)	NC score	0.041755 (rank : 312)
Query Neighborhood Hits	240	Target Neighborhood Hits	1537	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CEND1_HUMAN
θ value	3.0926 (rank : 177)	NC score	0.055135 (rank : 284)
Query Neighborhood Hits	240	Target Neighborhood Hits	284	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	3.0926 (rank : 178)	NC score	0.048986 (rank : 305)
Query Neighborhood Hits	240	Target Neighborhood Hits	260	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

DC1L2_MOUSE
θ value	3.0926 (rank : 179)	NC score	0.007395 (rank : 365)
Query Neighborhood Hits	240	Target Neighborhood Hits	173	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

ENAM_HUMAN
θ value	3.0926 (rank : 180)	NC score	0.014529 (rank : 349)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

GP152_MOUSE
θ value	3.0926 (rank : 181)	NC score	0.002081 (rank : 387)
Query Neighborhood Hits	240	Target Neighborhood Hits	607	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

KIFC2_HUMAN
θ value	3.0926 (rank : 182)	NC score	0.001754 (rank : 390)
Query Neighborhood Hits	240	Target Neighborhood Hits	237	Shared Neighborhood Hits	14
SwissProt Accessions	Q96AC6	Gene names	KIFC2
Domain Architecture
Description	Kinesin-like protein KIFC2.

MYH8_HUMAN
θ value	3.0926 (rank : 183)	NC score	0.021202 (rank : 336)
Query Neighborhood Hits	240	Target Neighborhood Hits	1610	Shared Neighborhood Hits	53
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

OBSCN_HUMAN
θ value	3.0926 (rank : 184)	NC score	0.057958 (rank : 271)
Query Neighborhood Hits	240	Target Neighborhood Hits	1931	Shared Neighborhood Hits	88
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OGFR_HUMAN
θ value	3.0926 (rank : 185)	NC score	0.023639 (rank : 329)
Query Neighborhood Hits	240	Target Neighborhood Hits	1582	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

TBC16_HUMAN
θ value	3.0926 (rank : 186)	NC score	0.006785 (rank : 370)
Query Neighborhood Hits	240	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TBP0	Gene names	TBC1D16
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 16.

TENS4_HUMAN
θ value	3.0926 (rank : 187)	NC score	0.008017 (rank : 362)
Query Neighborhood Hits	240	Target Neighborhood Hits	214	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TTLL4_MOUSE
θ value	3.0926 (rank : 188)	NC score	0.008700 (rank : 359)
Query Neighborhood Hits	240	Target Neighborhood Hits	103	Shared Neighborhood Hits	12
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

K1802_HUMAN
θ value	4.03905 (rank : 189)	NC score	0.003052 (rank : 384)
Query Neighborhood Hits	240	Target Neighborhood Hits	1378	Shared Neighborhood Hits	45
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MEF2D_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.009797 (rank : 357)
Query Neighborhood Hits	240	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	Q14814, Q14815	Gene names	MEF2D
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

SET1A_HUMAN
θ value	4.03905 (rank : 191)	NC score	0.023348 (rank : 330)
Query Neighborhood Hits	240	Target Neighborhood Hits	690	Shared Neighborhood Hits	42
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SETBP_MOUSE
θ value	4.03905 (rank : 192)	NC score	0.010674 (rank : 354)
Query Neighborhood Hits	240	Target Neighborhood Hits	352	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

STK31_HUMAN
θ value	4.03905 (rank : 193)	NC score	0.017617 (rank : 343)
Query Neighborhood Hits	240	Target Neighborhood Hits	570	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

TTLL5_MOUSE
θ value	4.03905 (rank : 194)	NC score	0.007082 (rank : 367)
Query Neighborhood Hits	240	Target Neighborhood Hits	150	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

ZEP1_HUMAN
θ value	4.03905 (rank : 195)	NC score	-0.005129 (rank : 398)
Query Neighborhood Hits	240	Target Neighborhood Hits	1036	Shared Neighborhood Hits	18
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

ZN438_HUMAN
θ value	4.03905 (rank : 196)	NC score	-0.004535 (rank : 397)
Query Neighborhood Hits	240	Target Neighborhood Hits	906	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

ASCL2_MOUSE
θ value	5.27518 (rank : 197)	NC score	0.004118 (rank : 379)
Query Neighborhood Hits	240	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

E2F5_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.005481 (rank : 374)
Query Neighborhood Hits	240	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q61502	Gene names	E2f5
Domain Architecture
Description	Transcription factor E2F5 (E2F-5).

GPS2_HUMAN
θ value	5.27518 (rank : 199)	NC score	0.023081 (rank : 331)
Query Neighborhood Hits	240	Target Neighborhood Hits	459	Shared Neighborhood Hits	25
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

IQEC3_HUMAN
θ value	5.27518 (rank : 200)	NC score	0.047405 (rank : 306)
Query Neighborhood Hits	240	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IRF3_HUMAN
θ value	5.27518 (rank : 201)	NC score	0.003743 (rank : 382)
Query Neighborhood Hits	240	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

JHD3B_HUMAN
θ value	5.27518 (rank : 202)	NC score	0.006767 (rank : 371)
Query Neighborhood Hits	240	Target Neighborhood Hits	128	Shared Neighborhood Hits	12
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

K1210_HUMAN
θ value	5.27518 (rank : 203)	NC score	0.016262 (rank : 345)
Query Neighborhood Hits	240	Target Neighborhood Hits	219	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

M3K7_MOUSE
θ value	5.27518 (rank : 204)	NC score	-0.005556 (rank : 399)
Query Neighborhood Hits	240	Target Neighborhood Hits	892	Shared Neighborhood Hits	10
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

NCOA6_HUMAN
θ value	5.27518 (rank : 205)	NC score	0.022486 (rank : 332)
Query Neighborhood Hits	240	Target Neighborhood Hits	1202	Shared Neighborhood Hits	68
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NU153_HUMAN
θ value	5.27518 (rank : 206)	NC score	0.007061 (rank : 368)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

PALM_MOUSE
θ value	5.27518 (rank : 207)	NC score	0.012850 (rank : 351)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

PIAS1_HUMAN
θ value	5.27518 (rank : 208)	NC score	0.007408 (rank : 364)
Query Neighborhood Hits	240	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).

TOR1A_MOUSE
θ value	5.27518 (rank : 209)	NC score	0.004035 (rank : 380)
Query Neighborhood Hits	240	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ER39	Gene names	Tor1a, Dyt1
Domain Architecture
Description	Torsin A precursor (Torsin family 1 member A) (Dystonia 1 protein).

ACOT1_HUMAN
θ value	6.88961 (rank : 210)	NC score	0.008043 (rank : 361)
Query Neighborhood Hits	240	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).

ANK3_HUMAN
θ value	6.88961 (rank : 211)	NC score	0.000196 (rank : 392)
Query Neighborhood Hits	240	Target Neighborhood Hits	853	Shared Neighborhood Hits	22
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANR11_HUMAN
θ value	6.88961 (rank : 212)	NC score	0.004007 (rank : 381)
Query Neighborhood Hits	240	Target Neighborhood Hits	1289	Shared Neighborhood Hits	39
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

CENA1_HUMAN
θ value	6.88961 (rank : 213)	NC score	0.032557 (rank : 319)
Query Neighborhood Hits	240	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

ESAM_MOUSE
θ value	6.88961 (rank : 214)	NC score	0.005166 (rank : 375)
Query Neighborhood Hits	240	Target Neighborhood Hits	222	Shared Neighborhood Hits	6
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

G25L_MOUSE
θ value	6.88961 (rank : 215)	NC score	0.004672 (rank : 377)
Query Neighborhood Hits	240	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2R4	Gene names
Domain Architecture	No domain graphic available
Description	Glycoprotein 25L precursor (GP25L).

GAK5_HUMAN
θ value	6.88961 (rank : 216)	NC score	0.002646 (rank : 385)
Query Neighborhood Hits	240	Target Neighborhood Hits	429	Shared Neighborhood Hits	26
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GP152_HUMAN
θ value	6.88961 (rank : 217)	NC score	0.001274 (rank : 391)
Query Neighborhood Hits	240	Target Neighborhood Hits	636	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

NSD1_MOUSE
θ value	6.88961 (rank : 218)	NC score	0.010308 (rank : 355)
Query Neighborhood Hits	240	Target Neighborhood Hits	472	Shared Neighborhood Hits	23
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PCQAP_MOUSE
θ value	6.88961 (rank : 219)	NC score	0.022481 (rank : 333)
Query Neighborhood Hits	240	Target Neighborhood Hits	506	Shared Neighborhood Hits	33
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

SCO1_HUMAN
θ value	6.88961 (rank : 220)	NC score	0.008511 (rank : 360)
Query Neighborhood Hits	240	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	O75880	Gene names	SCO1, SCOD1
Domain Architecture
Description	SCO1 protein homolog, mitochondrial precursor.

SEN34_MOUSE
θ value	6.88961 (rank : 221)	NC score	0.006880 (rank : 369)
Query Neighborhood Hits	240	Target Neighborhood Hits	158	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

SRRM2_MOUSE
θ value	6.88961 (rank : 222)	NC score	0.021029 (rank : 337)
Query Neighborhood Hits	240	Target Neighborhood Hits	1470	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TCF20_MOUSE
θ value	6.88961 (rank : 223)	NC score	0.020326 (rank : 340)
Query Neighborhood Hits	240	Target Neighborhood Hits	396	Shared Neighborhood Hits	31
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

VEZA_HUMAN
θ value	6.88961 (rank : 224)	NC score	0.018655 (rank : 341)
Query Neighborhood Hits	240	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HBM0, Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91	Gene names	VEZT
Domain Architecture	No domain graphic available
Description	Vezatin.

ARBK1_HUMAN
θ value	8.99809 (rank : 225)	NC score	-0.002863 (rank : 395)
Query Neighborhood Hits	240	Target Neighborhood Hits	859	Shared Neighborhood Hits	18
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

BAT2_MOUSE
θ value	8.99809 (rank : 226)	NC score	0.015703 (rank : 347)
Query Neighborhood Hits	240	Target Neighborhood Hits	947	Shared Neighborhood Hits	49
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CAMKV_HUMAN
θ value	8.99809 (rank : 227)	NC score	-0.000961 (rank : 393)
Query Neighborhood Hits	240	Target Neighborhood Hits	1084	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CDT1_HUMAN
θ value	8.99809 (rank : 228)	NC score	0.007557 (rank : 363)
Query Neighborhood Hits	240	Target Neighborhood Hits	92	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0	Gene names	CDT1
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP).

DLG1_HUMAN
θ value	8.99809 (rank : 229)	NC score	0.026321 (rank : 327)
Query Neighborhood Hits	240	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DPOA2_HUMAN
θ value	8.99809 (rank : 230)	NC score	0.005077 (rank : 376)
Query Neighborhood Hits	240	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q14181, Q9BPV3	Gene names	POLA2
Domain Architecture
Description	DNA polymerase subunit alpha B (DNA polymerase alpha 70 kDa subunit).

EDD1_MOUSE
θ value	8.99809 (rank : 231)	NC score	0.002037 (rank : 388)
Query Neighborhood Hits	240	Target Neighborhood Hits	167	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

MRCKB_HUMAN
θ value	8.99809 (rank : 232)	NC score	0.017513 (rank : 344)
Query Neighborhood Hits	240	Target Neighborhood Hits	2239	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MTMRD_HUMAN
θ value	8.99809 (rank : 233)	NC score	0.034117 (rank : 316)
Query Neighborhood Hits	240	Target Neighborhood Hits	135	Shared Neighborhood Hits	32
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

MYH1_HUMAN
θ value	8.99809 (rank : 234)	NC score	0.016031 (rank : 346)
Query Neighborhood Hits	240	Target Neighborhood Hits	1478	Shared Neighborhood Hits	43
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYO15_HUMAN
θ value	8.99809 (rank : 235)	NC score	0.006240 (rank : 373)
Query Neighborhood Hits	240	Target Neighborhood Hits	671	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PDK3_MOUSE
θ value	8.99809 (rank : 236)	NC score	0.001880 (rank : 389)
Query Neighborhood Hits	240	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q922H2, Q8BTX1	Gene names	Pdk3
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3).

PIAS1_MOUSE
θ value	8.99809 (rank : 237)	NC score	0.006685 (rank : 372)
Query Neighborhood Hits	240	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	O88907, Q8C6H5	Gene names	Pias1, Ddxbp1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (DEAD/H box-binding protein 1).

SEM6A_HUMAN
θ value	8.99809 (rank : 238)	NC score	0.002089 (rank : 386)
Query Neighborhood Hits	240	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H2E6, Q9P2H9	Gene names	SEMA6A, KIAA1368
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1).

SPTA3_HUMAN
θ value	8.99809 (rank : 239)	NC score	0.010210 (rank : 356)
Query Neighborhood Hits	240	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHX4, Q86WX5, Q8N9Y6	Gene names	SPATA3, TSARG1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1).

SSFA2_HUMAN
θ value	8.99809 (rank : 240)	NC score	0.017950 (rank : 342)
Query Neighborhood Hits	240	Target Neighborhood Hits	40	Shared Neighborhood Hits	9
SwissProt Accessions	P28290, Q96E36	Gene names	SSFA2, CS1
Domain Architecture	No domain graphic available
Description	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1).

ABI1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.053523 (rank : 291)
Query Neighborhood Hits	240	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.056374 (rank : 276)
Query Neighborhood Hits	240	Target Neighborhood Hits	246	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.059763 (rank : 261)
Query Neighborhood Hits	240	Target Neighborhood Hits	350	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.057985 (rank : 270)
Query Neighborhood Hits	240	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.052915 (rank : 293)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	29
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.051297 (rank : 300)
Query Neighborhood Hits	240	Target Neighborhood Hits	537	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ALS2_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.087615 (rank : 171)
Query Neighborhood Hits	240	Target Neighborhood Hits	111	Shared Neighborhood Hits	26
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.281058 (rank : 103)
Query Neighborhood Hits	240	Target Neighborhood Hits	176	Shared Neighborhood Hits	60
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.257272 (rank : 117)
Query Neighborhood Hits	240	Target Neighborhood Hits	266	Shared Neighborhood Hits	60
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.289350 (rank : 98)
Query Neighborhood Hits	240	Target Neighborhood Hits	142	Shared Neighborhood Hits	55
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG3_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.319234 (rank : 89)
Query Neighborhood Hits	240	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.319095 (rank : 90)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

BI2L1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.055704 (rank : 280)
Query Neighborhood Hits	240	Target Neighborhood Hits	156	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CA106_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.080578 (rank : 204)
Query Neighborhood Hits	240	Target Neighborhood Hits	124	Shared Neighborhood Hits	15
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CA106_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.080877 (rank : 202)
Query Neighborhood Hits	240	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CD2AP_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.085849 (rank : 175)
Query Neighborhood Hits	240	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.085378 (rank : 180)
Query Neighborhood Hits	240	Target Neighborhood Hits	336	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD45_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.078573 (rank : 214)
Query Neighborhood Hits	240	Target Neighborhood Hits	243	Shared Neighborhood Hits	15
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.080707 (rank : 203)
Query Neighborhood Hits	240	Target Neighborhood Hits	178	Shared Neighborhood Hits	12
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

EEA1_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.069525 (rank : 234)
Query Neighborhood Hits	240	Target Neighborhood Hits	1796	Shared Neighborhood Hits	60
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.073697 (rank : 228)
Query Neighborhood Hits	240	Target Neighborhood Hits	1637	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EP15R_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.050849 (rank : 303)
Query Neighborhood Hits	240	Target Neighborhood Hits	1083	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.051009 (rank : 302)
Query Neighborhood Hits	240	Target Neighborhood Hits	1135	Shared Neighborhood Hits	44
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

FRMD1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.472429 (rank : 57)
Query Neighborhood Hits	240	Target Neighborhood Hits	48	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

FYCO1_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.071292 (rank : 231)
Query Neighborhood Hits	240	Target Neighborhood Hits	1149	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.065715 (rank : 243)
Query Neighborhood Hits	240	Target Neighborhood Hits	1059	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

FYV1_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.085097 (rank : 184)
Query Neighborhood Hits	240	Target Neighborhood Hits	217	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.083468 (rank : 194)
Query Neighborhood Hits	240	Target Neighborhood Hits	191	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GNRP_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.307150 (rank : 94)
Query Neighborhood Hits	240	Target Neighborhood Hits	239	Shared Neighborhood Hits	84
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GRAP2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.055349 (rank : 283)
Query Neighborhood Hits	240	Target Neighborhood Hits	304	Shared Neighborhood Hits	26
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.055732 (rank : 279)
Query Neighborhood Hits	240	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.059413 (rank : 264)
Query Neighborhood Hits	240	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.058302 (rank : 269)
Query Neighborhood Hits	240	Target Neighborhood Hits	309	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.055467 (rank : 282)
Query Neighborhood Hits	240	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.055480 (rank : 281)
Query Neighborhood Hits	240	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.059547 (rank : 263)
Query Neighborhood Hits	240	Target Neighborhood Hits	358	Shared Neighborhood Hits	33
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.060305 (rank : 259)
Query Neighborhood Hits	240	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.110972 (rank : 143)
Query Neighborhood Hits	240	Target Neighborhood Hits	517	Shared Neighborhood Hits	35
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.113492 (rank : 141)
Query Neighborhood Hits	240	Target Neighborhood Hits	589	Shared Neighborhood Hits	47
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

KRIT1_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.062905 (rank : 253)
Query Neighborhood Hits	240	Target Neighborhood Hits	258	Shared Neighborhood Hits	22
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

KRIT1_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.057640 (rank : 272)
Query Neighborhood Hits	240	Target Neighborhood Hits	258	Shared Neighborhood Hits	24
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

LBC_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.277579 (rank : 106)
Query Neighborhood Hits	240	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MTMR3_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.074646 (rank : 222)
Query Neighborhood Hits	240	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

NCF1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.094774 (rank : 152)
Query Neighborhood Hits	240	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.087778 (rank : 170)
Query Neighborhood Hits	240	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.075235 (rank : 219)
Query Neighborhood Hits	240	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.073900 (rank : 226)
Query Neighborhood Hits	240	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.072369 (rank : 230)
Query Neighborhood Hits	240	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.069246 (rank : 235)
Query Neighborhood Hits	240	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.066279 (rank : 242)
Query Neighborhood Hits	240	Target Neighborhood Hits	310	Shared Neighborhood Hits	29
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.050259 (rank : 304)
Query Neighborhood Hits	240	Target Neighborhood Hits	457	Shared Neighborhood Hits	32
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PLEK2_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.060309 (rank : 258)
Query Neighborhood Hits	240	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.060827 (rank : 256)
Query Neighborhood Hits	240	Target Neighborhood Hits	96	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PPIP1_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.054407 (rank : 287)
Query Neighborhood Hits	240	Target Neighborhood Hits	389	Shared Neighborhood Hits	30
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.057220 (rank : 274)
Query Neighborhood Hits	240	Target Neighborhood Hits	377	Shared Neighborhood Hits	34
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PTN11_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.084108 (rank : 190)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	13
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.084119 (rank : 189)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	13
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN12_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.085541 (rank : 177)
Query Neighborhood Hits	240	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.085401 (rank : 179)
Query Neighborhood Hits	240	Target Neighborhood Hits	123	Shared Neighborhood Hits	12
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN18_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.092859 (rank : 159)
Query Neighborhood Hits	240	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.089915 (rank : 168)
Query Neighborhood Hits	240	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN1_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.092570 (rank : 160)
Query Neighborhood Hits	240	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.092863 (rank : 158)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN22_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.087320 (rank : 172)
Query Neighborhood Hits	240	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.085927 (rank : 174)
Query Neighborhood Hits	240	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.084144 (rank : 188)
Query Neighborhood Hits	240	Target Neighborhood Hits	646	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.082758 (rank : 196)
Query Neighborhood Hits	240	Target Neighborhood Hits	726	Shared Neighborhood Hits	43
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.092565 (rank : 161)
Query Neighborhood Hits	240	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.093532 (rank : 155)
Query Neighborhood Hits	240	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN5_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.080159 (rank : 205)
Query Neighborhood Hits	240	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.080159 (rank : 206)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN6_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.090003 (rank : 167)
Query Neighborhood Hits	240	Target Neighborhood Hits	234	Shared Neighborhood Hits	14
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.089614 (rank : 169)
Query Neighborhood Hits	240	Target Neighborhood Hits	225	Shared Neighborhood Hits	14
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.085566 (rank : 176)
Query Neighborhood Hits	240	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.086515 (rank : 173)
Query Neighborhood Hits	240	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.090662 (rank : 165)
Query Neighborhood Hits	240	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.090472 (rank : 166)
Query Neighborhood Hits	240	Target Neighborhood Hits	78	Shared Neighborhood Hits	10
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPR2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.083588 (rank : 193)
Query Neighborhood Hits	240	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.084699 (rank : 186)
Query Neighborhood Hits	240	Target Neighborhood Hits	120	Shared Neighborhood Hits	14
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRA_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.074476 (rank : 224)
Query Neighborhood Hits	240	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.074487 (rank : 223)
Query Neighborhood Hits	240	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRB_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.077938 (rank : 215)
Query Neighborhood Hits	240	Target Neighborhood Hits	242	Shared Neighborhood Hits	9
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRD_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.053516 (rank : 292)
Query Neighborhood Hits	240	Target Neighborhood Hits	485	Shared Neighborhood Hits	13
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.051384 (rank : 299)
Query Neighborhood Hits	240	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRE_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.074738 (rank : 221)
Query Neighborhood Hits	240	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.074346 (rank : 225)
Query Neighborhood Hits	240	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRF_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.052025 (rank : 295)
Query Neighborhood Hits	240	Target Neighborhood Hits	489	Shared Neighborhood Hits	12
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRG_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.065640 (rank : 244)
Query Neighborhood Hits	240	Target Neighborhood Hits	231	Shared Neighborhood Hits	9
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.066590 (rank : 240)
Query Neighborhood Hits	240	Target Neighborhood Hits	260	Shared Neighborhood Hits	19
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRJ_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.079852 (rank : 210)
Query Neighborhood Hits	240	Target Neighborhood Hits	207	Shared Neighborhood Hits	10
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.080083 (rank : 207)
Query Neighborhood Hits	240	Target Neighborhood Hits	188	Shared Neighborhood Hits	8
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRK_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.066465 (rank : 241)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.067045 (rank : 238)
Query Neighborhood Hits	240	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRM_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.062280 (rank : 255)
Query Neighborhood Hits	240	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.062968 (rank : 252)
Query Neighborhood Hits	240	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRN_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.083971 (rank : 191)
Query Neighborhood Hits	240	Target Neighborhood Hits	156	Shared Neighborhood Hits	13
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.083811 (rank : 192)
Query Neighborhood Hits	240	Target Neighborhood Hits	240	Shared Neighborhood Hits	16
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRO_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.084272 (rank : 187)
Query Neighborhood Hits	240	Target Neighborhood Hits	139	Shared Neighborhood Hits	9
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRR_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.081690 (rank : 199)
Query Neighborhood Hits	240	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.081979 (rank : 198)
Query Neighborhood Hits	240	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRS_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.054547 (rank : 285)
Query Neighborhood Hits	240	Target Neighborhood Hits	472	Shared Neighborhood Hits	11
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRT_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.064801 (rank : 248)
Query Neighborhood Hits	240	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.064896 (rank : 247)
Query Neighborhood Hits	240	Target Neighborhood Hits	219	Shared Neighborhood Hits	10
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRU_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.062882 (rank : 254)
Query Neighborhood Hits	240	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRV_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.079283 (rank : 212)
Query Neighborhood Hits	240	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTPRZ_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.066782 (rank : 239)
Query Neighborhood Hits	240	Target Neighborhood Hits	255	Shared Neighborhood Hits	13
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

RBNS5_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.110571 (rank : 144)
Query Neighborhood Hits	240	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.109906 (rank : 145)
Query Neighborhood Hits	240	Target Neighborhood Hits	266	Shared Neighborhood Hits	26
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RHG25_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.058583 (rank : 267)
Query Neighborhood Hits	240	Target Neighborhood Hits	550	Shared Neighborhood Hits	58
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.058756 (rank : 266)
Query Neighborhood Hits	240	Target Neighborhood Hits	492	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RIMB1_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.051957 (rank : 296)
Query Neighborhood Hits	240	Target Neighborhood Hits	1479	Shared Neighborhood Hits	67
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.054401 (rank : 288)
Query Neighborhood Hits	240	Target Neighborhood Hits	1376	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUFY1_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.075900 (rank : 218)
Query Neighborhood Hits	240	Target Neighborhood Hits	765	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.085477 (rank : 178)
Query Neighborhood Hits	240	Target Neighborhood Hits	1208	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.090878 (rank : 164)
Query Neighborhood Hits	240	Target Neighborhood Hits	820	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.059186 (rank : 265)
Query Neighborhood Hits	240	Target Neighborhood Hits	307	Shared Neighborhood Hits	25
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.052544 (rank : 294)
Query Neighborhood Hits	240	Target Neighborhood Hits	291	Shared Neighborhood Hits	21
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.051819 (rank : 298)
Query Neighborhood Hits	240	Target Neighborhood Hits	324	Shared Neighborhood Hits	23
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.051260 (rank : 301)
Query Neighborhood Hits	240	Target Neighborhood Hits	319	Shared Neighborhood Hits	23
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.054457 (rank : 286)
Query Neighborhood Hits	240	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.056209 (rank : 277)
Query Neighborhood Hits	240	Target Neighborhood Hits	236	Shared Neighborhood Hits	21
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.091471 (rank : 163)
Query Neighborhood Hits	240	Target Neighborhood Hits	341	Shared Neighborhood Hits	31
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.085220 (rank : 183)
Query Neighborhood Hits	240	Target Neighborhood Hits	332	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.073082 (rank : 229)
Query Neighborhood Hits	240	Target Neighborhood Hits	396	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.073783 (rank : 227)
Query Neighborhood Hits	240	Target Neighborhood Hits	409	Shared Neighborhood Hits	32
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.056417 (rank : 275)
Query Neighborhood Hits	240	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.056060 (rank : 278)
Query Neighborhood Hits	240	Target Neighborhood Hits	292	Shared Neighborhood Hits	26
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.053677 (rank : 290)
Query Neighborhood Hits	240	Target Neighborhood Hits	390	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAC3_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.063374 (rank : 250)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	22
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.063657 (rank : 249)
Query Neighborhood Hits	240	Target Neighborhood Hits	232	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.065335 (rank : 245)
Query Neighborhood Hits	240	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.063038 (rank : 251)
Query Neighborhood Hits	240	Target Neighborhood Hits	268	Shared Neighborhood Hits	26
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.060152 (rank : 260)
Query Neighborhood Hits	240	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.059688 (rank : 262)
Query Neighborhood Hits	240	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.057582 (rank : 273)
Query Neighborhood Hits	240	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.058565 (rank : 268)
Query Neighborhood Hits	240	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SWP70_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.075093 (rank : 220)
Query Neighborhood Hits	240	Target Neighborhood Hits	973	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.083018 (rank : 195)
Query Neighborhood Hits	240	Target Neighborhood Hits	1097	Shared Neighborhood Hits	78
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TCGAP_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.051953 (rank : 297)
Query Neighborhood Hits	240	Target Neighborhood Hits	872	Shared Neighborhood Hits	57
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.054329 (rank : 289)
Query Neighborhood Hits	240	Target Neighborhood Hits	409	Shared Neighborhood Hits	44
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VAV2_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.256293 (rank : 118)
Query Neighborhood Hits	240	Target Neighborhood Hits	453	Shared Neighborhood Hits	71
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.260031 (rank : 116)
Query Neighborhood Hits	240	Target Neighborhood Hits	456	Shared Neighborhood Hits	70
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VINEX_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.070693 (rank : 232)
Query Neighborhood Hits	240	Target Neighborhood Hits	270	Shared Neighborhood Hits	29
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.070013 (rank : 233)
Query Neighborhood Hits	240	Target Neighborhood Hits	286	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WDFY1_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.081129 (rank : 200)
Query Neighborhood Hits	240	Target Neighborhood Hits	305	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.068532 (rank : 237)
Query Neighborhood Hits	240	Target Neighborhood Hits	332	Shared Neighborhood Hits	17
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.069043 (rank : 236)
Query Neighborhood Hits	240	Target Neighborhood Hits	337	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY3_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.076332 (rank : 216)
Query Neighborhood Hits	240	Target Neighborhood Hits	348	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.075962 (rank : 217)
Query Neighborhood Hits	240	Target Neighborhood Hits	332	Shared Neighborhood Hits	17
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ZFY16_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.140941 (rank : 135)
Query Neighborhood Hits	240	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.144925 (rank : 131)
Query Neighborhood Hits	240	Target Neighborhood Hits	108	Shared Neighborhood Hits	20
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.092179 (rank : 162)
Query Neighborhood Hits	240	Target Neighborhood Hits	206	Shared Neighborhood Hits	18
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.085361 (rank : 181)
Query Neighborhood Hits	240	Target Neighborhood Hits	143	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.139638 (rank : 136)
Query Neighborhood Hits	240	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.142436 (rank : 134)
Query Neighborhood Hits	240	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.155379 (rank : 128)
Query Neighborhood Hits	240	Target Neighborhood Hits	152	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.095373 (rank : 151)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.093580 (rank : 154)
Query Neighborhood Hits	240	Target Neighborhood Hits	153	Shared Neighborhood Hits	18
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.152465 (rank : 129)
Query Neighborhood Hits	240	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

FARP2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	240	Target Neighborhood Hits	240	Shared Neighborhood Hits	240
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
NC score	0.989644 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	240	Target Neighborhood Hits	209	Shared Neighborhood Hits	164
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
NC score	0.974867 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	240	Target Neighborhood Hits	241	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

E41L3_HUMAN
NC score	0.778548 (rank : 4)	θ value	1.31681e-67 (rank : 5)
Query Neighborhood Hits	240	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L5_HUMAN
NC score	0.776713 (rank : 5)	θ value	5.73848e-55 (rank : 13)
Query Neighborhood Hits	240	Target Neighborhood Hits	76	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.776370 (rank : 6)	θ value	9.16162e-53 (rank : 14)
Query Neighborhood Hits	240	Target Neighborhood Hits	59	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

FRMD5_MOUSE
NC score	0.774025 (rank : 7)	θ value	1.85029e-45 (rank : 18)
Query Neighborhood Hits	240	Target Neighborhood Hits	55	Shared Neighborhood Hits	47
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

41_HUMAN
NC score	0.774002 (rank : 8)	θ value	4.68348e-65 (rank : 8)
Query Neighborhood Hits	240	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L1_MOUSE
NC score	0.773333 (rank : 9)	θ value	1.15359e-63 (rank : 10)
Query Neighborhood Hits	240	Target Neighborhood Hits	106	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41LB_HUMAN
NC score	0.772088 (rank : 10)	θ value	1.32293e-51 (rank : 15)
Query Neighborhood Hits	240	Target Neighborhood Hits	79	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

FRMD5_HUMAN
NC score	0.771713 (rank : 11)	θ value	9.18288e-45 (rank : 20)
Query Neighborhood Hits	240	Target Neighborhood Hits	55	Shared Neighborhood Hits	47
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

41_MOUSE
NC score	0.770658 (rank : 12)	θ value	1.11734e-58 (rank : 12)
Query Neighborhood Hits	240	Target Neighborhood Hits	184	Shared Neighborhood Hits	52
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L1_HUMAN
NC score	0.769471 (rank : 13)	θ value	5.17823e-64 (rank : 9)
Query Neighborhood Hits	240	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L3_MOUSE
NC score	0.767503 (rank : 14)	θ value	5.00389e-67 (rank : 6)
Query Neighborhood Hits	240	Target Neighborhood Hits	250	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41LA_HUMAN
NC score	0.763844 (rank : 15)	θ value	7.27602e-42 (rank : 21)
Query Neighborhood Hits	240	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41L2_HUMAN
NC score	0.763105 (rank : 16)	θ value	2.10232e-65 (rank : 7)
Query Neighborhood Hits	240	Target Neighborhood Hits	287	Shared Neighborhood Hits	51
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41LA_MOUSE
NC score	0.761924 (rank : 17)	θ value	1.98146e-39 (rank : 24)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	48
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41L2_MOUSE
NC score	0.748099 (rank : 18)	θ value	2.56992e-63 (rank : 11)
Query Neighborhood Hits	240	Target Neighborhood Hits	459	Shared Neighborhood Hits	57
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

MYLIP_MOUSE
NC score	0.703668 (rank : 19)	θ value	1.37858e-24 (rank : 44)
Query Neighborhood Hits	240	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_HUMAN
NC score	0.692525 (rank : 20)	θ value	6.18819e-25 (rank : 43)
Query Neighborhood Hits	240	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

FRM4B_HUMAN
NC score	0.649467 (rank : 21)	θ value	1.5773e-20 (rank : 50)
Query Neighborhood Hits	240	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
NC score	0.647414 (rank : 22)	θ value	7.82807e-20 (rank : 53)
Query Neighborhood Hits	240	Target Neighborhood Hits	109	Shared Neighborhood Hits	48
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

FRM4A_MOUSE
NC score	0.644433 (rank : 23)	θ value	1.2077e-20 (rank : 49)
Query Neighborhood Hits	240	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_HUMAN
NC score	0.642894 (rank : 24)	θ value	3.51386e-20 (rank : 52)
Query Neighborhood Hits	240	Target Neighborhood Hits	110	Shared Neighborhood Hits	46
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

MERL_MOUSE
NC score	0.636187 (rank : 25)	θ value	2.27234e-27 (rank : 38)
Query Neighborhood Hits	240	Target Neighborhood Hits	524	Shared Neighborhood Hits	58
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MERL_HUMAN
NC score	0.635601 (rank : 26)	θ value	1.73987e-27 (rank : 37)
Query Neighborhood Hits	240	Target Neighborhood Hits	532	Shared Neighborhood Hits	58
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

EZRI_HUMAN
NC score	0.606571 (rank : 27)	θ value	1.4233e-29 (rank : 34)
Query Neighborhood Hits	240	Target Neighborhood Hits	663	Shared Neighborhood Hits	60
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
NC score	0.603611 (rank : 28)	θ value	4.89182e-30 (rank : 33)
Query Neighborhood Hits	240	Target Neighborhood Hits	693	Shared Neighborhood Hits	60
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

RADI_HUMAN
NC score	0.594469 (rank : 29)	θ value	8.06329e-33 (rank : 27)
Query Neighborhood Hits	240	Target Neighborhood Hits	741	Shared Neighborhood Hits	63
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
NC score	0.590821 (rank : 30)	θ value	8.06329e-33 (rank : 28)
Query Neighborhood Hits	240	Target Neighborhood Hits	773	Shared Neighborhood Hits	62
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

FGD4_HUMAN
NC score	0.565967 (rank : 31)	θ value	1.08474e-45 (rank : 17)
Query Neighborhood Hits	240	Target Neighborhood Hits	219	Shared Neighborhood Hits	96
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.565602 (rank : 32)	θ value	3.72821e-46 (rank : 16)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	94
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

MOES_HUMAN
NC score	0.559633 (rank : 33)	θ value	1.16434e-31 (rank : 30)
Query Neighborhood Hits	240	Target Neighborhood Hits	892	Shared Neighborhood Hits	68
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FGD1_HUMAN
NC score	0.558136 (rank : 34)	θ value	8.32485e-38 (rank : 25)
Query Neighborhood Hits	240	Target Neighborhood Hits	367	Shared Neighborhood Hits	101
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.555124 (rank : 35)	θ value	8.32485e-38 (rank : 26)
Query Neighborhood Hits	240	Target Neighborhood Hits	387	Shared Neighborhood Hits	96
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_MOUSE
NC score	0.553170 (rank : 36)	θ value	3.28125e-26 (rank : 40)
Query Neighborhood Hits	240	Target Neighborhood Hits	257	Shared Neighborhood Hits	88
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

MOES_MOUSE
NC score	0.553109 (rank : 37)	θ value	8.91499e-32 (rank : 29)
Query Neighborhood Hits	240	Target Neighborhood Hits	923	Shared Neighborhood Hits	68
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

PTN4_HUMAN
NC score	0.549199 (rank : 38)	θ value	3.45727e-76 (rank : 4)
Query Neighborhood Hits	240	Target Neighborhood Hits	303	Shared Neighborhood Hits	52
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

FGD2_HUMAN
NC score	0.548710 (rank : 39)	θ value	2.59989e-23 (rank : 46)
Query Neighborhood Hits	240	Target Neighborhood Hits	151	Shared Neighborhood Hits	82
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD6_MOUSE
NC score	0.546555 (rank : 40)	θ value	3.05695e-40 (rank : 23)
Query Neighborhood Hits	240	Target Neighborhood Hits	282	Shared Neighborhood Hits	95
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD2_MOUSE
NC score	0.546418 (rank : 41)	θ value	4.42448e-31 (rank : 31)
Query Neighborhood Hits	240	Target Neighborhood Hits	163	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
NC score	0.545492 (rank : 42)	θ value	1.47289e-26 (rank : 39)
Query Neighborhood Hits	240	Target Neighborhood Hits	249	Shared Neighborhood Hits	74
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD6_HUMAN
NC score	0.542723 (rank : 43)	θ value	6.15952e-41 (rank : 22)
Query Neighborhood Hits	240	Target Neighborhood Hits	237	Shared Neighborhood Hits	95
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PTN3_HUMAN
NC score	0.524154 (rank : 44)	θ value	3.15612e-45 (rank : 19)
Query Neighborhood Hits	240	Target Neighborhood Hits	258	Shared Neighborhood Hits	52
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

FRMD6_MOUSE
NC score	0.509111 (rank : 45)	θ value	0.00020696 (rank : 107)
Query Neighborhood Hits	240	Target Neighborhood Hits	63	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

PREX1_HUMAN
NC score	0.507474 (rank : 46)	θ value	2.69047e-20 (rank : 51)
Query Neighborhood Hits	240	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FRMD6_HUMAN
NC score	0.501007 (rank : 47)	θ value	0.000461057 (rank : 108)
Query Neighborhood Hits	240	Target Neighborhood Hits	60	Shared Neighborhood Hits	42
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

PTN21_MOUSE
NC score	0.499246 (rank : 48)	θ value	1.85889e-29 (rank : 35)
Query Neighborhood Hits	240	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

FGD5_HUMAN
NC score	0.499008 (rank : 49)	θ value	5.77852e-31 (rank : 32)
Query Neighborhood Hits	240	Target Neighborhood Hits	235	Shared Neighborhood Hits	72
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

PTN21_HUMAN
NC score	0.497698 (rank : 50)	θ value	2.68423e-28 (rank : 36)
Query Neighborhood Hits	240	Target Neighborhood Hits	143	Shared Neighborhood Hits	47
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

ARHG4_MOUSE
NC score	0.490762 (rank : 51)	θ value	1.16704e-23 (rank : 45)
Query Neighborhood Hits	240	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD5_MOUSE
NC score	0.489406 (rank : 52)	θ value	2.12685e-25 (rank : 41)
Query Neighborhood Hits	240	Target Neighborhood Hits	170	Shared Neighborhood Hits	76
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PKHG1_HUMAN
NC score	0.484203 (rank : 53)	θ value	1.16975e-15 (rank : 58)
Query Neighborhood Hits	240	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PTN14_MOUSE
NC score	0.482198 (rank : 54)	θ value	9.87957e-23 (rank : 47)
Query Neighborhood Hits	240	Target Neighborhood Hits	142	Shared Neighborhood Hits	47
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

ARHG4_HUMAN
NC score	0.477962 (rank : 55)	θ value	3.62785e-25 (rank : 42)
Query Neighborhood Hits	240	Target Neighborhood Hits	242	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PTN14_HUMAN
NC score	0.476238 (rank : 56)	θ value	1.42661e-21 (rank : 48)
Query Neighborhood Hits	240	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

FRMD1_HUMAN
NC score	0.472429 (rank : 57)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	240	Target Neighborhood Hits	48	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

ARHG9_HUMAN
NC score	0.463146 (rank : 58)	θ value	3.07829e-16 (rank : 56)
Query Neighborhood Hits	240	Target Neighborhood Hits	235	Shared Neighborhood Hits	69
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.462183 (rank : 59)	θ value	3.07829e-16 (rank : 57)
Query Neighborhood Hits	240	Target Neighborhood Hits	234	Shared Neighborhood Hits	69
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ECT2_MOUSE
NC score	0.446212 (rank : 60)	θ value	1.17247e-07 (rank : 89)
Query Neighborhood Hits	240	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.437300 (rank : 61)	θ value	4.45536e-07 (rank : 92)
Query Neighborhood Hits	240	Target Neighborhood Hits	98	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGG_HUMAN
NC score	0.412503 (rank : 62)	θ value	1.25267e-09 (rank : 75)
Query Neighborhood Hits	240	Target Neighborhood Hits	129	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.406668 (rank : 63)	θ value	5.62301e-10 (rank : 73)
Query Neighborhood Hits	240	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

TIAM1_HUMAN
NC score	0.403819 (rank : 64)	θ value	1.9326e-10 (rank : 72)
Query Neighborhood Hits	240	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.403588 (rank : 65)	θ value	1.47974e-10 (rank : 71)
Query Neighborhood Hits	240	Target Neighborhood Hits	205	Shared Neighborhood Hits	77
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG5_HUMAN
NC score	0.396695 (rank : 66)	θ value	1.17247e-07 (rank : 88)
Query Neighborhood Hits	240	Target Neighborhood Hits	172	Shared Neighborhood Hits	63
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_HUMAN
NC score	0.395808 (rank : 67)	θ value	1.53129e-07 (rank : 90)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

MCF2_HUMAN
NC score	0.389477 (rank : 68)	θ value	1.43324e-05 (rank : 100)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NGEF_MOUSE
NC score	0.389207 (rank : 69)	θ value	5.26297e-08 (rank : 85)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PTN13_MOUSE
NC score	0.382729 (rank : 70)	θ value	4.74913e-17 (rank : 55)
Query Neighborhood Hits	240	Target Neighborhood Hits	426	Shared Neighborhood Hits	56
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN13_HUMAN
NC score	0.376143 (rank : 71)	θ value	2.13179e-17 (rank : 54)
Query Neighborhood Hits	240	Target Neighborhood Hits	471	Shared Neighborhood Hits	59
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

ARHG7_HUMAN
NC score	0.375417 (rank : 72)	θ value	1.29331e-14 (rank : 59)
Query Neighborhood Hits	240	Target Neighborhood Hits	347	Shared Neighborhood Hits	75
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHGA_HUMAN
NC score	0.364562 (rank : 73)	θ value	0.00175202 (rank : 116)
Query Neighborhood Hits	240	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.360220 (rank : 74)	θ value	0.0113563 (rank : 121)
Query Neighborhood Hits	240	Target Neighborhood Hits	125	Shared Neighborhood Hits	59
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG7_MOUSE
NC score	0.358665 (rank : 75)	θ value	6.64225e-11 (rank : 70)
Query Neighborhood Hits	240	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

MCF2L_MOUSE
NC score	0.356290 (rank : 76)	θ value	3.19293e-05 (rank : 101)
Query Neighborhood Hits	240	Target Neighborhood Hits	255	Shared Neighborhood Hits	68
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHGF_HUMAN
NC score	0.352903 (rank : 77)	θ value	0.279714 (rank : 135)
Query Neighborhood Hits	240	Target Neighborhood Hits	214	Shared Neighborhood Hits	73
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

HAPIP_HUMAN
NC score	0.350168 (rank : 78)	θ value	4.1701e-05 (rank : 102)
Query Neighborhood Hits	240	Target Neighborhood Hits	350	Shared Neighborhood Hits	73
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

GNRP_MOUSE
NC score	0.349727 (rank : 79)	θ value	1.02475e-11 (rank : 65)
Query Neighborhood Hits	240	Target Neighborhood Hits	191	Shared Neighborhood Hits	84
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG8_HUMAN
NC score	0.346890 (rank : 80)	θ value	9.92553e-07 (rank : 93)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG2_MOUSE
NC score	0.346830 (rank : 81)	θ value	7.34386e-10 (rank : 74)
Query Neighborhood Hits	240	Target Neighborhood Hits	120	Shared Neighborhood Hits	58
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG6_HUMAN
NC score	0.335442 (rank : 82)	θ value	5.08577e-11 (rank : 69)
Query Neighborhood Hits	240	Target Neighborhood Hits	376	Shared Neighborhood Hits	65
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PKHG4_HUMAN
NC score	0.333324 (rank : 83)	θ value	0.00175202 (rank : 117)
Query Neighborhood Hits	240	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHGB_HUMAN
NC score	0.333041 (rank : 84)	θ value	1.06045e-08 (rank : 81)
Query Neighborhood Hits	240	Target Neighborhood Hits	375	Shared Neighborhood Hits	71
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG6_MOUSE
NC score	0.325338 (rank : 85)	θ value	2.0648e-12 (rank : 61)
Query Neighborhood Hits	240	Target Neighborhood Hits	394	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PKHF2_HUMAN
NC score	0.324296 (rank : 86)	θ value	8.11959e-09 (rank : 79)
Query Neighborhood Hits	240	Target Neighborhood Hits	75	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.323875 (rank : 87)	θ value	8.11959e-09 (rank : 80)
Query Neighborhood Hits	240	Target Neighborhood Hits	77	Shared Neighborhood Hits	30
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ARHG8_MOUSE
NC score	0.321138 (rank : 88)	θ value	1.43324e-05 (rank : 99)
Query Neighborhood Hits	240	Target Neighborhood Hits	79	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG3_HUMAN
NC score	0.319234 (rank : 89)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	240	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.319095 (rank : 90)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

DNMBP_MOUSE
NC score	0.318374 (rank : 91)	θ value	4.76016e-09 (rank : 76)
Query Neighborhood Hits	240	Target Neighborhood Hits	435	Shared Neighborhood Hits	69
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PKHF1_MOUSE
NC score	0.317447 (rank : 92)	θ value	4.0297e-08 (rank : 84)
Query Neighborhood Hits	240	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
NC score	0.317248 (rank : 93)	θ value	6.87365e-08 (rank : 86)
Query Neighborhood Hits	240	Target Neighborhood Hits	76	Shared Neighborhood Hits	24
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

GNRP_HUMAN
NC score	0.307150 (rank : 94)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	240	Target Neighborhood Hits	239	Shared Neighborhood Hits	84
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHGC_HUMAN
NC score	0.304955 (rank : 95)	θ value	7.1131e-05 (rank : 104)
Query Neighborhood Hits	240	Target Neighborhood Hits	351	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

DNMBP_HUMAN
NC score	0.303203 (rank : 96)	θ value	1.38499e-08 (rank : 82)
Query Neighborhood Hits	240	Target Neighborhood Hits	413	Shared Neighborhood Hits	71
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGC_MOUSE
NC score	0.300886 (rank : 97)	θ value	0.00020696 (rank : 106)
Query Neighborhood Hits	240	Target Neighborhood Hits	344	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG2_HUMAN
NC score	0.289350 (rank : 98)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	240	Target Neighborhood Hits	142	Shared Neighborhood Hits	55
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ABR_HUMAN
NC score	0.286561 (rank : 99)	θ value	5.08577e-11 (rank : 68)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
NC score	0.285152 (rank : 100)	θ value	4.0297e-08 (rank : 83)
Query Neighborhood Hits	240	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ITSN2_HUMAN
NC score	0.284977 (rank : 101)	θ value	1.74796e-11 (rank : 67)
Query Neighborhood Hits	240	Target Neighborhood Hits	1173	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

TLN1_HUMAN
NC score	0.282569 (rank : 102)	θ value	0.163984 (rank : 131)
Query Neighborhood Hits	240	Target Neighborhood Hits	218	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

ARHG1_HUMAN
NC score	0.281058 (rank : 103)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	240	Target Neighborhood Hits	176	Shared Neighborhood Hits	60
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ITSN2_MOUSE
NC score	0.279506 (rank : 104)	θ value	1.33837e-11 (rank : 66)
Query Neighborhood Hits	240	Target Neighborhood Hits	1371	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

TLN1_MOUSE
NC score	0.278528 (rank : 105)	θ value	0.47712 (rank : 141)
Query Neighborhood Hits	240	Target Neighborhood Hits	213	Shared Neighborhood Hits	52
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

LBC_HUMAN
NC score	0.277579 (rank : 106)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	240	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ITSN1_MOUSE
NC score	0.274357 (rank : 107)	θ value	2.69671e-12 (rank : 62)
Query Neighborhood Hits	240	Target Neighborhood Hits	1669	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.272028 (rank : 108)	θ value	2.43908e-13 (rank : 60)
Query Neighborhood Hits	240	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

TLN2_MOUSE
NC score	0.271712 (rank : 109)	θ value	1.38821 (rank : 164)
Query Neighborhood Hits	240	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TLN2_HUMAN
NC score	0.269036 (rank : 110)	θ value	1.06291 (rank : 161)
Query Neighborhood Hits	240	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

VAV_MOUSE
NC score	0.268921 (rank : 111)	θ value	0.000602161 (rank : 110)
Query Neighborhood Hits	240	Target Neighborhood Hits	430	Shared Neighborhood Hits	67
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

RGNEF_MOUSE
NC score	0.265463 (rank : 112)	θ value	0.000786445 (rank : 112)
Query Neighborhood Hits	240	Target Neighborhood Hits	641	Shared Neighborhood Hits	71
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

VAV3_MOUSE
NC score	0.264653 (rank : 113)	θ value	9.92553e-07 (rank : 97)
Query Neighborhood Hits	240	Target Neighborhood Hits	404	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
NC score	0.263388 (rank : 114)	θ value	0.00665767 (rank : 120)
Query Neighborhood Hits	240	Target Neighborhood Hits	452	Shared Neighborhood Hits	65
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV3_HUMAN
NC score	0.260725 (rank : 115)	θ value	9.92553e-07 (rank : 96)
Query Neighborhood Hits	240	Target Neighborhood Hits	398	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
NC score	0.260031 (rank : 116)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	240	Target Neighborhood Hits	456	Shared Neighborhood Hits	70
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG1_MOUSE
NC score	0.257272 (rank : 117)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	240	Target Neighborhood Hits	266	Shared Neighborhood Hits	60
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

VAV2_HUMAN
NC score	0.256293 (rank : 118)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	240	Target Neighborhood Hits	453	Shared Neighborhood Hits	71
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SOS1_HUMAN
NC score	0.234235 (rank : 119)	θ value	6.87365e-08 (rank : 87)
Query Neighborhood Hits	240	Target Neighborhood Hits	274	Shared Neighborhood Hits	53
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

PKHA6_MOUSE
NC score	0.228420 (rank : 120)	θ value	4.76016e-09 (rank : 77)
Query Neighborhood Hits	240	Target Neighborhood Hits	591	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SOS2_HUMAN
NC score	0.225380 (rank : 121)	θ value	9.92553e-07 (rank : 95)
Query Neighborhood Hits	240	Target Neighborhood Hits	193	Shared Neighborhood Hits	53
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_MOUSE
NC score	0.221992 (rank : 122)	θ value	9.92553e-07 (rank : 94)
Query Neighborhood Hits	240	Target Neighborhood Hits	281	Shared Neighborhood Hits	52
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

PKHA6_HUMAN
NC score	0.219572 (rank : 123)	θ value	8.11959e-09 (rank : 78)
Query Neighborhood Hits	240	Target Neighborhood Hits	556	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA5_HUMAN
NC score	0.173093 (rank : 124)	θ value	2.61198e-07 (rank : 91)
Query Neighborhood Hits	240	Target Neighborhood Hits	455	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_MOUSE
NC score	0.170540 (rank : 125)	θ value	0.00102713 (rank : 113)
Query Neighborhood Hits	240	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA2_MOUSE
NC score	0.164595 (rank : 126)	θ value	1.29631e-06 (rank : 98)
Query Neighborhood Hits	240	Target Neighborhood Hits	116	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
NC score	0.159877 (rank : 127)	θ value	0.00228821 (rank : 118)
Query Neighborhood Hits	240	Target Neighborhood Hits	283	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

ZFY28_HUMAN
NC score	0.155379 (rank : 128)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	240	Target Neighborhood Hits	152	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.152465 (rank : 129)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	240	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PKHA2_HUMAN
NC score	0.152036 (rank : 130)	θ value	4.1701e-05 (rank : 103)
Query Neighborhood Hits	240	Target Neighborhood Hits	119	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

ZFY16_MOUSE
NC score	0.144925 (rank : 131)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	240	Target Neighborhood Hits	108	Shared Neighborhood Hits	20
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

DUET_HUMAN
NC score	0.144732 (rank : 132)	θ value	3.52202e-12 (rank : 63)
Query Neighborhood Hits	240	Target Neighborhood Hits	1220	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.142602 (rank : 133)	θ value	6.00763e-12 (rank : 64)
Query Neighborhood Hits	240	Target Neighborhood Hits	1580	Shared Neighborhood Hits	95
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ZFY21_MOUSE
NC score	0.142436 (rank : 134)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	240	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_HUMAN
NC score	0.140941 (rank : 135)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	240	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.139638 (rank : 136)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	240	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

PLEK_HUMAN
NC score	0.134279 (rank : 137)	θ value	0.000158464 (rank : 105)
Query Neighborhood Hits	240	Target Neighborhood Hits	110	Shared Neighborhood Hits	44
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
NC score	0.126571 (rank : 138)	θ value	0.000786445 (rank : 111)
Query Neighborhood Hits	240	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PKHA1_MOUSE
NC score	0.118184 (rank : 139)	θ value	0.00665767 (rank : 119)
Query Neighborhood Hits	240	Target Neighborhood Hits	120	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.117259 (rank : 140)	θ value	0.0252991 (rank : 124)
Query Neighborhood Hits	240	Target Neighborhood Hits	127	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

HGS_MOUSE
NC score	0.113492 (rank : 141)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	240	Target Neighborhood Hits	589	Shared Neighborhood Hits	47
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

CNKR1_HUMAN
NC score	0.112011 (rank : 142)	θ value	1.38821 (rank : 162)
Query Neighborhood Hits	240	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

HGS_HUMAN
NC score	0.110972 (rank : 143)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	240	Target Neighborhood Hits	517	Shared Neighborhood Hits	35
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

RBNS5_HUMAN
NC score	0.110571 (rank : 144)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	240	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.109906 (rank : 145)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	240	Target Neighborhood Hits	266	Shared Neighborhood Hits	26
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

CNKR2_MOUSE
NC score	0.101204 (rank : 146)	θ value	0.62314 (rank : 146)
Query Neighborhood Hits	240	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.100849 (rank : 147)	θ value	0.62314 (rank : 145)
Query Neighborhood Hits	240	Target Neighborhood Hits	197	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

C43BP_MOUSE
NC score	0.099120 (rank : 148)	θ value	0.00134147 (rank : 115)
Query Neighborhood Hits	240	Target Neighborhood Hits	91	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_HUMAN
NC score	0.098049 (rank : 149)	θ value	0.00134147 (rank : 114)
Query Neighborhood Hits	240	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CYH3_MOUSE
NC score	0.096146 (rank : 150)	θ value	0.0148317 (rank : 122)
Query Neighborhood Hits	240	Target Neighborhood Hits	148	Shared Neighborhood Hits	48
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

ZFYV1_HUMAN
NC score	0.095373 (rank : 151)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

NCF1_HUMAN
NC score	0.094774 (rank : 152)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	240	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ALS2_HUMAN
NC score	0.094352 (rank : 153)	θ value	0.0330416 (rank : 125)
Query Neighborhood Hits	240	Target Neighborhood Hits	121	Shared Neighborhood Hits	27
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ZFYV1_MOUSE
NC score	0.093580 (rank : 154)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	240	Target Neighborhood Hits	153	Shared Neighborhood Hits	18
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

PTN2_MOUSE
NC score	0.093532 (rank : 155)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	240	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

3BP2_MOUSE
NC score	0.093344 (rank : 156)	θ value	1.06291 (rank : 156)
Query Neighborhood Hits	240	Target Neighborhood Hits	142	Shared Neighborhood Hits	36
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_HUMAN
NC score	0.092885 (rank : 157)	θ value	0.813845 (rank : 151)
Query Neighborhood Hits	240	Target Neighborhood Hits	296	Shared Neighborhood Hits	43
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PTN1_MOUSE
NC score	0.092863 (rank : 158)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN18_HUMAN
NC score	0.092859 (rank : 159)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	240	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN1_HUMAN
NC score	0.092570 (rank : 160)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	240	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN2_HUMAN
NC score	0.092565 (rank : 161)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	240	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

ZFY19_HUMAN
NC score	0.092179 (rank : 162)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	240	Target Neighborhood Hits	206	Shared Neighborhood Hits	18
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

SH3K1_HUMAN
NC score	0.091471 (rank : 163)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	240	Target Neighborhood Hits	341	Shared Neighborhood Hits	31
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

RUFY2_MOUSE
NC score	0.090878 (rank : 164)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	240	Target Neighborhood Hits	820	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PTN9_HUMAN
NC score	0.090662 (rank : 165)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	240	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
NC score	0.090472 (rank : 166)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	240	Target Neighborhood Hits	78	Shared Neighborhood Hits	10
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN6_HUMAN
NC score	0.090003 (rank : 167)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	240	Target Neighborhood Hits	234	Shared Neighborhood Hits	14
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN18_MOUSE
NC score	0.089915 (rank : 168)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	240	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN6_MOUSE
NC score	0.089614 (rank : 169)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	240	Target Neighborhood Hits	225	Shared Neighborhood Hits	14
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

NCF1_MOUSE
NC score	0.087778 (rank : 170)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	240	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ALS2_MOUSE
NC score	0.087615 (rank : 171)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	240	Target Neighborhood Hits	111	Shared Neighborhood Hits	26
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

PTN22_HUMAN
NC score	0.087320 (rank : 172)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	240	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN7_MOUSE
NC score	0.086515 (rank : 173)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	240	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN22_MOUSE
NC score	0.085927 (rank : 174)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	240	Target Neighborhood Hits	179	Shared Neighborhood Hits	14
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

CD2AP_HUMAN
NC score	0.085849 (rank : 175)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	240	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

PTN7_HUMAN
NC score	0.085566 (rank : 176)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	240	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN12_HUMAN
NC score	0.085541 (rank : 177)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	240	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

RUFY2_HUMAN
NC score	0.085477 (rank : 178)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	240	Target Neighborhood Hits	1208	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PTN12_MOUSE
NC score	0.085401 (rank : 179)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	240	Target Neighborhood Hits	123	Shared Neighborhood Hits	12
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

CD2AP_MOUSE
NC score	0.085378 (rank : 180)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	240	Target Neighborhood Hits	336	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ZFY19_MOUSE
NC score	0.085361 (rank : 181)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	240	Target Neighborhood Hits	143	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

CYH3_HUMAN
NC score	0.085267 (rank : 182)	θ value	0.0736092 (rank : 127)
Query Neighborhood Hits	240	Target Neighborhood Hits	137	Shared Neighborhood Hits	41
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

SH3K1_MOUSE
NC score	0.085220 (rank : 183)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	240	Target Neighborhood Hits	332	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

FYV1_HUMAN
NC score	0.085097 (rank : 184)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	240	Target Neighborhood Hits	217	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

RUFY1_HUMAN
NC score	0.084767 (rank : 185)	θ value	2.36792 (rank : 174)
Query Neighborhood Hits	240	Target Neighborhood Hits	848	Shared Neighborhood Hits	42
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

PTPR2_MOUSE
NC score	0.084699 (rank : 186)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	240	Target Neighborhood Hits	120	Shared Neighborhood Hits	14
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRO_HUMAN
NC score	0.084272 (rank : 187)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	240	Target Neighborhood Hits	139	Shared Neighborhood Hits	9
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTN23_HUMAN
NC score	0.084144 (rank : 188)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	240	Target Neighborhood Hits	646	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN11_MOUSE
NC score	0.084119 (rank : 189)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	13
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.084108 (rank : 190)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	13
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTPRN_HUMAN
NC score	0.083971 (rank : 191)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	240	Target Neighborhood Hits	156	Shared Neighborhood Hits	13
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
NC score	0.083811 (rank : 192)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	240	Target Neighborhood Hits	240	Shared Neighborhood Hits	16
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPR2_HUMAN
NC score	0.083588 (rank : 193)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	240	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

FYV1_MOUSE
NC score	0.083468 (rank : 194)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	240	Target Neighborhood Hits	191	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

SWP70_MOUSE
NC score	0.083018 (rank : 195)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	240	Target Neighborhood Hits	1097	Shared Neighborhood Hits	78
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PTN23_MOUSE
NC score	0.082758 (rank : 196)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	240	Target Neighborhood Hits	726	Shared Neighborhood Hits	43
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

CYH4_MOUSE
NC score	0.082232 (rank : 197)	θ value	0.62314 (rank : 148)
Query Neighborhood Hits	240	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PTPRR_MOUSE
NC score	0.081979 (rank : 198)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	240	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRR_HUMAN
NC score	0.081690 (rank : 199)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	240	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

WDFY1_HUMAN
NC score	0.081129 (rank : 200)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	240	Target Neighborhood Hits	305	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

CYH1_HUMAN
NC score	0.081093 (rank : 201)	θ value	0.813845 (rank : 153)
Query Neighborhood Hits	240	Target Neighborhood Hits	184	Shared Neighborhood Hits	53
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CA106_MOUSE
NC score	0.080877 (rank : 202)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	240	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CD45_MOUSE
NC score	0.080707 (rank : 203)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	240	Target Neighborhood Hits	178	Shared Neighborhood Hits	12
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

CA106_HUMAN
NC score	0.080578 (rank : 204)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	240	Target Neighborhood Hits	124	Shared Neighborhood Hits	15
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

PTN5_HUMAN
NC score	0.080159 (rank : 205)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	240	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
NC score	0.080159 (rank : 206)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	240	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTPRJ_MOUSE
NC score	0.080083 (rank : 207)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	240	Target Neighborhood Hits	188	Shared Neighborhood Hits	8
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

CYH2_HUMAN
NC score	0.079858 (rank : 208)	θ value	0.21417 (rank : 132)
Query Neighborhood Hits	240	Target Neighborhood Hits	175	Shared Neighborhood Hits	48
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.079853 (rank : 209)	θ value	0.21417 (rank : 133)
Query Neighborhood Hits	240	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PTPRJ_HUMAN
NC score	0.079852 (rank : 210)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	240	Target Neighborhood Hits	207	Shared Neighborhood Hits	10
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

CYH4_HUMAN
NC score	0.079396 (rank : 211)	θ value	0.62314 (rank : 147)
Query Neighborhood Hits	240	Target Neighborhood Hits	135	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PTPRV_MOUSE
NC score	0.079283 (rank : 212)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	240	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

CYH1_MOUSE
NC score	0.078845 (rank : 213)	θ value	0.813845 (rank : 154)
Query Neighborhood Hits	240	Target Neighborhood Hits	176	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CD45_HUMAN
NC score	0.078573 (rank : 214)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	240	Target Neighborhood Hits	243	Shared Neighborhood Hits	15
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

PTPRB_HUMAN
NC score	0.077938 (rank : 215)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	240	Target Neighborhood Hits	242	Shared Neighborhood Hits	9
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

WDFY3_HUMAN
NC score	0.076332 (rank : 216)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	240	Target Neighborhood Hits	348	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
NC score	0.075962 (rank : 217)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	240	Target Neighborhood Hits	332	Shared Neighborhood Hits	17
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

RUFY1_MOUSE
NC score	0.075900 (rank : 218)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	240	Target Neighborhood Hits	765	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

NCF2_HUMAN
NC score	0.075235 (rank : 219)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	240	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SWP70_HUMAN
NC score	0.075093 (rank : 220)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	240	Target Neighborhood Hits	973	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PTPRE_HUMAN
NC score	0.074738 (rank : 221)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	240	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

MTMR3_HUMAN
NC score	0.074646 (rank : 222)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	240	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

PTPRA_MOUSE
NC score	0.074487 (rank : 223)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	240	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRA_HUMAN
NC score	0.074476 (rank : 224)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	240	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRE_MOUSE
NC score	0.074346 (rank : 225)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	240	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

NCF4_HUMAN
NC score	0.073900 (rank : 226)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	240	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SRBS1_MOUSE
NC score	0.073783 (rank : 227)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	240	Target Neighborhood Hits	409	Shared Neighborhood Hits	32
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

EEA1_MOUSE
NC score	0.073697 (rank : 228)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	240	Target Neighborhood Hits	1637	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SRBS1_HUMAN
NC score	0.073082 (rank : 229)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	240	Target Neighborhood Hits	396	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF4_MOUSE
NC score	0.072369 (rank : 230)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	240	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

FYCO1_HUMAN
NC score	0.071292 (rank : 231)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	240	Target Neighborhood Hits	1149	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

VINEX_HUMAN
NC score	0.070693 (rank : 232)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	240	Target Neighborhood Hits	270	Shared Neighborhood Hits	29
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.070013 (rank : 233)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	240	Target Neighborhood Hits	286	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

EEA1_HUMAN
NC score	0.069525 (rank : 234)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	240	Target Neighborhood Hits	1796	Shared Neighborhood Hits	60
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

NCK1_HUMAN
NC score	0.069246 (rank : 235)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	240	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

WDFY2_MOUSE
NC score	0.069043 (rank : 236)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	240	Target Neighborhood Hits	337	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.068532 (rank : 237)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	240	Target Neighborhood Hits	332	Shared Neighborhood Hits	17
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

PTPRK_MOUSE
NC score	0.067045 (rank : 238)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	240	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRZ_HUMAN
NC score	0.066782 (rank : 239)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	240	Target Neighborhood Hits	255	Shared Neighborhood Hits	13
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PTPRG_MOUSE
NC score	0.066590 (rank : 240)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	240	Target Neighborhood Hits	260	Shared Neighborhood Hits	19
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRK_HUMAN
NC score	0.066465 (rank : 241)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

NCK2_HUMAN
NC score	0.066279 (rank : 242)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	240	Target Neighborhood Hits	310	Shared Neighborhood Hits	29
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

FYCO1_MOUSE
NC score	0.065715 (rank : 243)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	240	Target Neighborhood Hits	1059	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

PTPRG_HUMAN
NC score	0.065640 (rank : 244)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	240	Target Neighborhood Hits	231	Shared Neighborhood Hits	9
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

STAC_HUMAN
NC score	0.065335 (rank : 245)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	240	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

OSBL9_HUMAN
NC score	0.065335 (rank : 246)	θ value	0.365318 (rank : 138)
Query Neighborhood Hits	240	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PTPRT_MOUSE
NC score	0.064896 (rank : 247)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	240	Target Neighborhood Hits	219	Shared Neighborhood Hits	10
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRT_HUMAN
NC score	0.064801 (rank : 248)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	240	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

STAC3_MOUSE
NC score	0.063657 (rank : 249)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	240	Target Neighborhood Hits	232	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.063374 (rank : 250)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	22
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_MOUSE
NC score	0.063038 (rank : 251)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	240	Target Neighborhood Hits	268	Shared Neighborhood Hits	26
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PTPRM_MOUSE
NC score	0.062968 (rank : 252)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	240	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

KRIT1_HUMAN
NC score	0.062905 (rank : 253)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	240	Target Neighborhood Hits	258	Shared Neighborhood Hits	22
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

PTPRU_HUMAN
NC score	0.062882 (rank : 254)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	240	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRM_HUMAN
NC score	0.062280 (rank : 255)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	240	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PLEK2_MOUSE
NC score	0.060827 (rank : 256)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	240	Target Neighborhood Hits	96	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

K1914_HUMAN
NC score	0.060688 (rank : 257)	θ value	0.365318 (rank : 137)
Query Neighborhood Hits	240	Target Neighborhood Hits	255	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

PLEK2_HUMAN
NC score	0.060309 (rank : 258)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	240	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

HCLS1_MOUSE
NC score	0.060305 (rank : 259)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	240	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

STAM1_HUMAN
NC score	0.060152 (rank : 260)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	240	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI2_HUMAN
NC score	0.059763 (rank : 261)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	240	Target Neighborhood Hits	350	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

STAM1_MOUSE
NC score	0.059688 (rank : 262)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	240	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

HCLS1_HUMAN
NC score	0.059547 (rank : 263)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	240	Target Neighborhood Hits	358	Shared Neighborhood Hits	33
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GRAP_HUMAN
NC score	0.059413 (rank : 264)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	240	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SH3G1_HUMAN
NC score	0.059186 (rank : 265)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	240	Target Neighborhood Hits	307	Shared Neighborhood Hits	25
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

RHG25_MOUSE
NC score	0.058756 (rank : 266)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	240	Target Neighborhood Hits	492	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.058583 (rank : 267)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	240	Target Neighborhood Hits	550	Shared Neighborhood Hits	58
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

STAM2_MOUSE
NC score	0.058565 (rank : 268)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	240	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

GRAP_MOUSE
NC score	0.058302 (rank : 269)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	240	Target Neighborhood Hits	309	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ABI2_MOUSE
NC score	0.057985 (rank : 270)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	240	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

OBSCN_HUMAN
NC score	0.057958 (rank : 271)	θ value	3.0926 (rank : 184)
Query Neighborhood Hits	240	Target Neighborhood Hits	1931	Shared Neighborhood Hits	88
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

KRIT1_MOUSE
NC score	0.057640 (rank : 272)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	240	Target Neighborhood Hits	258	Shared Neighborhood Hits	24
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

STAM2_HUMAN
NC score	0.057582 (rank : 273)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	240	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

PPIP1_MOUSE
NC score	0.057220 (rank : 274)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	240	Target Neighborhood Hits	377	Shared Neighborhood Hits	34
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SRC8_HUMAN
NC score	0.056417 (rank : 275)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	240	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ABI1_MOUSE
NC score	0.056374 (rank : 276)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	240	Target Neighborhood Hits	246	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G3_MOUSE
NC score	0.056209 (rank : 277)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	240	Target Neighborhood Hits	236	Shared Neighborhood Hits	21
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRC8_MOUSE
NC score	0.056060 (rank : 278)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	240	Target Neighborhood Hits	292	Shared Neighborhood Hits	26
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

GRAP2_MOUSE
NC score	0.055732 (rank : 279)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	240	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

BI2L1_HUMAN
NC score	0.055704 (rank : 280)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	240	Target Neighborhood Hits	156	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

GRB2_MOUSE
NC score	0.055480 (rank : 281)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	240	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.055467 (rank : 282)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	240	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRAP2_HUMAN
NC score	0.055349 (rank : 283)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	240	Target Neighborhood Hits	304	Shared Neighborhood Hits	26
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CEND1_HUMAN
NC score	0.055135 (rank : 284)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	240	Target Neighborhood Hits	284	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

PTPRS_HUMAN
NC score	0.054547 (rank : 285)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	240	Target Neighborhood Hits	472	Shared Neighborhood Hits	11
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

SH3G3_HUMAN
NC score	0.054457 (rank : 286)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	240	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

PPIP1_HUMAN
NC score	0.054407 (rank : 287)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	240	Target Neighborhood Hits	389	Shared Neighborhood Hits	30
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

RIMB1_MOUSE
NC score	0.054401 (rank : 288)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	240	Target Neighborhood Hits	1376	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TCGAP_MOUSE
NC score	0.054329 (rank : 289)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	240	Target Neighborhood Hits	409	Shared Neighborhood Hits	44
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SRGP1_HUMAN
NC score	0.053677 (rank : 290)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	240	Target Neighborhood Hits	390	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ABI1_HUMAN
NC score	0.053523 (rank : 291)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	240	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PTPRD_HUMAN
NC score	0.053516 (rank : 292)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	240	Target Neighborhood Hits	485	Shared Neighborhood Hits	13
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

ABI3_HUMAN
NC score	0.052915 (rank : 293)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	29
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G1_MOUSE
NC score	0.052544 (rank : 294)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	240	Target Neighborhood Hits	291	Shared Neighborhood Hits	21
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

PTPRF_HUMAN
NC score	0.052025 (rank : 295)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	240	Target Neighborhood Hits	489	Shared Neighborhood Hits	12
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

RIMB1_HUMAN
NC score	0.051957 (rank : 296)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	240	Target Neighborhood Hits	1479	Shared Neighborhood Hits	67
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TCGAP_HUMAN
NC score	0.051953 (rank : 297)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	240	Target Neighborhood Hits	872	Shared Neighborhood Hits	57
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SH3G2_HUMAN
NC score	0.051819 (rank : 298)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	240	Target Neighborhood Hits	324	Shared Neighborhood Hits	23
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PTPRD_MOUSE
NC score	0.051384 (rank : 299)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	240	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

AHI1_HUMAN
NC score	0.051297 (rank : 300)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	240	Target Neighborhood Hits	537	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

SH3G2_MOUSE
NC score	0.051260 (rank : 301)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	240	Target Neighborhood Hits	319	Shared Neighborhood Hits	23
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

EP15R_MOUSE
NC score	0.051009 (rank : 302)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	240	Target Neighborhood Hits	1135	Shared Neighborhood Hits	44
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15R_HUMAN
NC score	0.050849 (rank : 303)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	240	Target Neighborhood Hits	1083	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

NEBL_HUMAN
NC score	0.050259 (rank : 304)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	240	Target Neighborhood Hits	457	Shared Neighborhood Hits	32
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

CEND1_MOUSE
NC score	0.048986 (rank : 305)	θ value	3.0926 (rank : 178)
Query Neighborhood Hits	240	Target Neighborhood Hits	260	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

IQEC3_HUMAN
NC score	0.047405 (rank : 306)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	240	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

CEND2_HUMAN
NC score	0.045568 (rank : 307)	θ value	0.62314 (rank : 143)
Query Neighborhood Hits	240	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

IASPP_MOUSE
NC score	0.044615 (rank : 308)	θ value	0.47712 (rank : 140)
Query Neighborhood Hits	240	Target Neighborhood Hits	1024	Shared Neighborhood Hits	54
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

K1914_MOUSE
NC score	0.044316 (rank : 309)	θ value	2.36792 (rank : 171)
Query Neighborhood Hits	240	Target Neighborhood Hits	216	Shared Neighborhood Hits	25
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

IASPP_HUMAN
NC score	0.043234 (rank : 310)	θ value	2.36792 (rank : 170)
Query Neighborhood Hits	240	Target Neighborhood Hits	688	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CEND3_HUMAN
NC score	0.042365 (rank : 311)	θ value	0.62314 (rank : 144)
Query Neighborhood Hits	240	Target Neighborhood Hits	275	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

BSN_HUMAN
NC score	0.041755 (rank : 312)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	240	Target Neighborhood Hits	1537	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

RGS3_MOUSE
NC score	0.041003 (rank : 313)	θ value	0.000461057 (rank : 109)
Query Neighborhood Hits	240	Target Neighborhood Hits	1621	Shared Neighborhood Hits	63
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CEND3_MOUSE
NC score	0.040281 (rank : 314)	θ value	0.813845 (rank : 152)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

SPTB2_HUMAN
NC score	0.035471 (rank : 315)	θ value	0.62314 (rank : 149)
Query Neighborhood Hits	240	Target Neighborhood Hits	748	Shared Neighborhood Hits	48
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MTMRD_HUMAN
NC score	0.034117 (rank : 316)	θ value	8.99809 (rank : 233)
Query Neighborhood Hits	240	Target Neighborhood Hits	135	Shared Neighborhood Hits	32
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

SPTB2_MOUSE
NC score	0.033972 (rank : 317)	θ value	1.06291 (rank : 160)
Query Neighborhood Hits	240	Target Neighborhood Hits	770	Shared Neighborhood Hits	52
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

BSN_MOUSE
NC score	0.033841 (rank : 318)	θ value	1.06291 (rank : 157)
Query Neighborhood Hits	240	Target Neighborhood Hits	2057	Shared Neighborhood Hits	82
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CENA1_HUMAN
NC score	0.032557 (rank : 319)	θ value	6.88961 (rank : 213)
Query Neighborhood Hits	240	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SRRM2_HUMAN
NC score	0.031811 (rank : 320)	θ value	0.365318 (rank : 139)
Query Neighborhood Hits	240	Target Neighborhood Hits	1296	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SPTN2_HUMAN
NC score	0.031495 (rank : 321)	θ value	0.0431538 (rank : 126)
Query Neighborhood Hits	240	Target Neighborhood Hits	535	Shared Neighborhood Hits	45
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

ZIMP7_MOUSE
NC score	0.030815 (rank : 322)	θ value	0.0148317 (rank : 123)
Query Neighborhood Hits	240	Target Neighborhood Hits	566	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

PCLO_MOUSE
NC score	0.030713 (rank : 323)	θ value	0.0961366 (rank : 129)
Query Neighborhood Hits	240	Target Neighborhood Hits	2275	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

MLL3_HUMAN
NC score	0.030576 (rank : 324)	θ value	0.0961366 (rank : 128)
Query Neighborhood Hits	240	Target Neighborhood Hits	1644	Shared Neighborhood Hits	70
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

CSR2B_HUMAN
NC score	0.029484 (rank : 325)	θ value	0.163984 (rank : 130)
Query Neighborhood Hits	240	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8E8, Q96GW6, Q96IH3, Q9HBF0, Q9UIY5	Gene names	CSRP2BP
Domain Architecture
Description	Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (CRP2BP) (CRP2-binding partner).

MLL2_HUMAN
NC score	0.027155 (rank : 326)	θ value	0.21417 (rank : 134)
Query Neighborhood Hits	240	Target Neighborhood Hits	1788	Shared Neighborhood Hits	65
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

DLG1_HUMAN
NC score	0.026321 (rank : 327)	θ value	8.99809 (rank : 229)
Query Neighborhood Hits	240	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

STAP2_MOUSE
NC score	0.023965 (rank : 328)	θ value	1.38821 (rank : 163)
Query Neighborhood Hits	240	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

OGFR_HUMAN
NC score	0.023639 (rank : 329)	θ value	3.0926 (rank : 185)
Query Neighborhood Hits	240	Target Neighborhood Hits	1582	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

SET1A_HUMAN
NC score	0.023348 (rank : 330)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	240	Target Neighborhood Hits	690	Shared Neighborhood Hits	42
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

GPS2_HUMAN
NC score	0.023081 (rank : 331)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	240	Target Neighborhood Hits	459	Shared Neighborhood Hits	25
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

NCOA6_HUMAN
NC score	0.022486 (rank : 332)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	240	Target Neighborhood Hits	1202	Shared Neighborhood Hits	68
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PCQAP_MOUSE
NC score	0.022481 (rank : 333)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	240	Target Neighborhood Hits	506	Shared Neighborhood Hits	33
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

RGS3_HUMAN
NC score	0.022147 (rank : 334)	θ value	1.06291 (rank : 159)
Query Neighborhood Hits	240	Target Neighborhood Hits	1375	Shared Neighborhood Hits	47
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

MYH8_MOUSE
NC score	0.021889 (rank : 335)	θ value	2.36792 (rank : 172)
Query Neighborhood Hits	240	Target Neighborhood Hits	1600	Shared Neighborhood Hits	51
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_HUMAN
NC score	0.021202 (rank : 336)	θ value	3.0926 (rank : 183)
Query Neighborhood Hits	240	Target Neighborhood Hits	1610	Shared Neighborhood Hits	53
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SRRM2_MOUSE
NC score	0.021029 (rank : 337)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	240	Target Neighborhood Hits	1470	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

APC_HUMAN
NC score	0.020534 (rank : 338)	θ value	0.62314 (rank : 142)
Query Neighborhood Hits	240	Target Neighborhood Hits	603	Shared Neighborhood Hits	26
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

NCOR2_HUMAN
NC score	0.020522 (rank : 339)	θ value	0.813845 (rank : 155)
Query Neighborhood Hits	240	Target Neighborhood Hits	870	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

TCF20_MOUSE
NC score	0.020326 (rank : 340)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	240	Target Neighborhood Hits	396	Shared Neighborhood Hits	31
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

VEZA_HUMAN
NC score	0.018655 (rank : 341)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	240	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HBM0, Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91	Gene names	VEZT
Domain Architecture	No domain graphic available
Description	Vezatin.

SSFA2_HUMAN
NC score	0.017950 (rank : 342)	θ value	8.99809 (rank : 240)
Query Neighborhood Hits	240	Target Neighborhood Hits	40	Shared Neighborhood Hits	9
SwissProt Accessions	P28290, Q96E36	Gene names	SSFA2, CS1
Domain Architecture	No domain graphic available
Description	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1).

STK31_HUMAN
NC score	0.017617 (rank : 343)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	240	Target Neighborhood Hits	570	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

MRCKB_HUMAN
NC score	0.017513 (rank : 344)	θ value	8.99809 (rank : 232)
Query Neighborhood Hits	240	Target Neighborhood Hits	2239	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

K1210_HUMAN
NC score	0.016262 (rank : 345)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	240	Target Neighborhood Hits	219	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

MYH1_HUMAN
NC score	0.016031 (rank : 346)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	240	Target Neighborhood Hits	1478	Shared Neighborhood Hits	43
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

BAT2_MOUSE
NC score	0.015703 (rank : 347)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	240	Target Neighborhood Hits	947	Shared Neighborhood Hits	49
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

FOXN1_MOUSE
NC score	0.014690 (rank : 348)	θ value	0.279714 (rank : 136)
Query Neighborhood Hits	240	Target Neighborhood Hits	300	Shared Neighborhood Hits	18
SwissProt Accessions	Q61575	Gene names	Foxn1, Fkh19, Hfh11, Whn
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/forkhead homolog 11) (HFH-11).

ENAM_HUMAN
NC score	0.014529 (rank : 349)	θ value	3.0926 (rank : 180)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

DAB1_HUMAN
NC score	0.013970 (rank : 350)	θ value	1.06291 (rank : 158)
Query Neighborhood Hits	240	Target Neighborhood Hits	219	Shared Neighborhood Hits	15
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

PALM_MOUSE
NC score	0.012850 (rank : 351)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	240	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

MEF2D_MOUSE
NC score	0.011741 (rank : 352)	θ value	1.81305 (rank : 167)
Query Neighborhood Hits	240	Target Neighborhood Hits	146	Shared Neighborhood Hits	13
SwissProt Accessions	Q63943, Q63944	Gene names	Mef2d
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

ACOT2_HUMAN
NC score	0.011688 (rank : 353)	θ value	1.81305 (rank : 165)
Query Neighborhood Hits	240	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	P49753, Q9NUX4	Gene names	ACOT2, PTE2, PTE2A
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2 (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (ZAP128) (CTE-Ia).

SETBP_MOUSE
NC score	0.010674 (rank : 354)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	240	Target Neighborhood Hits	352	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

NSD1_MOUSE
NC score	0.010308 (rank : 355)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	240	Target Neighborhood Hits	472	Shared Neighborhood Hits	23
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

SPTA3_HUMAN
NC score	0.010210 (rank : 356)	θ value	8.99809 (rank : 239)
Query Neighborhood Hits	240	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHX4, Q86WX5, Q8N9Y6	Gene names	SPATA3, TSARG1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1).

MEF2D_HUMAN
NC score	0.009797 (rank : 357)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	240	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	Q14814, Q14815	Gene names	MEF2D
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

DEN1A_MOUSE
NC score	0.009375 (rank : 358)	θ value	1.81305 (rank : 166)
Query Neighborhood Hits	240	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K382	Gene names	Dennd1a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

TTLL4_MOUSE
NC score	0.008700 (rank : 359)	θ value	3.0926 (rank : 188)
Query Neighborhood Hits	240	Target Neighborhood Hits	103	Shared Neighborhood Hits	12
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

SCO1_HUMAN
NC score	0.008511 (rank : 360)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	240	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	O75880	Gene names	SCO1, SCOD1
Domain Architecture
Description	SCO1 protein homolog, mitochondrial precursor.

ACOT1_HUMAN
NC score	0.008043 (rank : 361)	θ value	6.88961 (rank : 210)
Query Neighborhood Hits	240	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).

TENS4_HUMAN
NC score	0.008017 (rank : 362)	θ value	3.0926 (rank : 187)
Query Neighborhood Hits	240	Target Neighborhood Hits	214	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

CDT1_HUMAN
NC score	0.007557 (rank : 363)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	240	Target Neighborhood Hits	92	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0	Gene names	CDT1
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP).

PIAS1_HUMAN
NC score	0.007408 (rank : 364)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	240	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).

DC1L2_MOUSE
NC score	0.007395 (rank : 365)	θ value	3.0926 (rank : 179)
Query Neighborhood Hits	240	Target Neighborhood Hits	173	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

RECQ5_HUMAN
NC score	0.007305 (rank : 366)	θ value	2.36792 (rank : 173)
Query Neighborhood Hits	240	Target Neighborhood Hits	390	Shared Neighborhood Hits	23
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

TTLL5_MOUSE
NC score	0.007082 (rank : 367)	θ value	4.03905 (rank : 194)
Query Neighborhood Hits	240	Target Neighborhood Hits	150	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

NU153_HUMAN
NC score	0.007061 (rank : 368)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	240	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

SEN34_MOUSE
NC score	0.006880 (rank : 369)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	240	Target Neighborhood Hits	158	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

TBC16_HUMAN
NC score	0.006785 (rank : 370)	θ value	3.0926 (rank : 186)
Query Neighborhood Hits	240	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TBP0	Gene names	TBC1D16
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 16.

JHD3B_HUMAN
NC score	0.006767 (rank : 371)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	240	Target Neighborhood Hits	128	Shared Neighborhood Hits	12
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

PIAS1_MOUSE
NC score	0.006685 (rank : 372)	θ value	8.99809 (rank : 237)
Query Neighborhood Hits	240	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	O88907, Q8C6H5	Gene names	Pias1, Ddxbp1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (DEAD/H box-binding protein 1).

MYO15_HUMAN
NC score	0.006240 (rank : 373)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	240	Target Neighborhood Hits	671	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

E2F5_MOUSE
NC score	0.005481 (rank : 374)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	240	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q61502	Gene names	E2f5
Domain Architecture
Description	Transcription factor E2F5 (E2F-5).

ESAM_MOUSE
NC score	0.005166 (rank : 375)	θ value	6.88961 (rank : 214)
Query Neighborhood Hits	240	Target Neighborhood Hits	222	Shared Neighborhood Hits	6
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

DPOA2_HUMAN
NC score	0.005077 (rank : 376)	θ value	8.99809 (rank : 230)
Query Neighborhood Hits	240	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q14181, Q9BPV3	Gene names	POLA2
Domain Architecture
Description	DNA polymerase subunit alpha B (DNA polymerase alpha 70 kDa subunit).

G25L_MOUSE
NC score	0.004672 (rank : 377)	θ value	6.88961 (rank : 215)
Query Neighborhood Hits	240	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2R4	Gene names
Domain Architecture	No domain graphic available
Description	Glycoprotein 25L precursor (GP25L).

TRIM7_HUMAN
NC score	0.004280 (rank : 378)	θ value	0.62314 (rank : 150)
Query Neighborhood Hits	240	Target Neighborhood Hits	336	Shared Neighborhood Hits	7
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

ASCL2_MOUSE
NC score	0.004118 (rank : 379)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	240	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

TOR1A_MOUSE
NC score	0.004035 (rank : 380)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	240	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ER39	Gene names	Tor1a, Dyt1
Domain Architecture
Description	Torsin A precursor (Torsin family 1 member A) (Dystonia 1 protein).

ANR11_HUMAN
NC score	0.004007 (rank : 381)	θ value	6.88961 (rank : 212)
Query Neighborhood Hits	240	Target Neighborhood Hits	1289	Shared Neighborhood Hits	39
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

IRF3_HUMAN
NC score	0.003743 (rank : 382)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	240	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

SOX7_HUMAN
NC score	0.003581 (rank : 383)	θ value	1.81305 (rank : 168)
Query Neighborhood Hits	240	Target Neighborhood Hits	140	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BT81	Gene names	SOX7
Domain Architecture
Description	Transcription factor SOX-7.

K1802_HUMAN
NC score	0.003052 (rank : 384)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	240	Target Neighborhood Hits	1378	Shared Neighborhood Hits	45
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

GAK5_HUMAN
NC score	0.002646 (rank : 385)	θ value	6.88961 (rank : 216)
Query Neighborhood Hits	240	Target Neighborhood Hits	429	Shared Neighborhood Hits	26
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

SEM6A_HUMAN
NC score	0.002089 (rank : 386)	θ value	8.99809 (rank : 238)
Query Neighborhood Hits	240	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H2E6, Q9P2H9	Gene names	SEMA6A, KIAA1368
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1).

GP152_MOUSE
NC score	0.002081 (rank : 387)	θ value	3.0926 (rank : 181)
Query Neighborhood Hits	240	Target Neighborhood Hits	607	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

EDD1_MOUSE
NC score	0.002037 (rank : 388)	θ value	8.99809 (rank : 231)
Query Neighborhood Hits	240	Target Neighborhood Hits	167	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

PDK3_MOUSE
NC score	0.001880 (rank : 389)	θ value	8.99809 (rank : 236)
Query Neighborhood Hits	240	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q922H2, Q8BTX1	Gene names	Pdk3
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3).

KIFC2_HUMAN
NC score	0.001754 (rank : 390)	θ value	3.0926 (rank : 182)
Query Neighborhood Hits	240	Target Neighborhood Hits	237	Shared Neighborhood Hits	14
SwissProt Accessions	Q96AC6	Gene names	KIFC2
Domain Architecture
Description	Kinesin-like protein KIFC2.

GP152_HUMAN
NC score	0.001274 (rank : 391)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	240	Target Neighborhood Hits	636	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

ANK3_HUMAN
NC score	0.000196 (rank : 392)	θ value	6.88961 (rank : 211)
Query Neighborhood Hits	240	Target Neighborhood Hits	853	Shared Neighborhood Hits	22
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

CAMKV_HUMAN
NC score	-0.000961 (rank : 393)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	240	Target Neighborhood Hits	1084	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

ULK1_MOUSE
NC score	-0.002625 (rank : 394)	θ value	2.36792 (rank : 175)
Query Neighborhood Hits	240	Target Neighborhood Hits	1214	Shared Neighborhood Hits	27
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ARBK1_HUMAN
NC score	-0.002863 (rank : 395)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	240	Target Neighborhood Hits	859	Shared Neighborhood Hits	18
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ZN516_MOUSE
NC score	-0.003864 (rank : 396)	θ value	1.81305 (rank : 169)
Query Neighborhood Hits	240	Target Neighborhood Hits	1197	Shared Neighborhood Hits	31
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ZN438_HUMAN
NC score	-0.004535 (rank : 397)	θ value	4.03905 (rank : 196)
Query Neighborhood Hits	240	Target Neighborhood Hits	906	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

ZEP1_HUMAN
NC score	-0.005129 (rank : 398)	θ value	4.03905 (rank : 195)
Query Neighborhood Hits	240	Target Neighborhood Hits	1036	Shared Neighborhood Hits	18
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

M3K7_MOUSE
NC score	-0.005556 (rank : 399)	θ value	5.27518 (rank : 204)
Query Neighborhood Hits	240	Target Neighborhood Hits	892	Shared Neighborhood Hits	10
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).