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Network neighborhood for query Sequence : PIAS1_HUMAN

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PIAS1_HUMAN
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PIAS1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).

PIAS1_MOUSE
θ value	0 (rank : 2)	NC score	0.998917 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	27
SwissProt Accessions	O88907, Q8C6H5	Gene names	Pias1, Ddxbp1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (DEAD/H box-binding protein 1).

PIAS3_HUMAN
θ value	0 (rank : 3)	NC score	0.987636 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	58	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6X2, Q9UFI3	Gene names	PIAS3
Domain Architecture
Description	Protein inhibitor of activated STAT protein 3.

PIAS3_MOUSE
θ value	0 (rank : 4)	NC score	0.986316 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	65	Shared Neighborhood Hits	14
SwissProt Accessions	O54714, Q80WF8, Q8R598	Gene names	Pias3
Domain Architecture
Description	Protein inhibitor of activated STAT protein 3.

PIAS2_HUMAN
θ value	6.77497e-173 (rank : 5)	NC score	0.989002 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	O75928, O75927, Q96BT5, Q96KE3	Gene names	PIAS2, PIASX
Domain Architecture	No domain graphic available
Description	Protein inhibitor of activated STAT2 (Protein inhibitor of activated STAT x) (Msx-interacting zinc finger protein) (Miz1) (DAB2-interacting protein) (DIP) (Androgen receptor-interacting protein 3) (ARIP3) (PIAS-NY protein).

PIAS2_MOUSE
θ value	7.49059e-172 (rank : 6)	NC score	0.989106 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C5D8, O54987, Q8C384, Q8CDQ8, Q8K208, Q99JX5, Q9D5W7, Q9QZ63	Gene names	Pias2, Miz1, Piasx
Domain Architecture	No domain graphic available
Description	Protein inhibitor of activated STAT2 (Protein inhibitor of activated STAT x) (Msx-interacting zinc finger protein) (DAB2-interacting protein) (DIP) (Androgen receptor-interacting protein 3) (ARIP3).

PIAS4_HUMAN
θ value	1.2549e-118 (rank : 7)	NC score	0.975959 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N2W9, O75926, Q96G19, Q9UN16	Gene names	PIAS4, PIASG
Domain Architecture
Description	Protein inhibitor of activated STAT protein 4 (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) (PIASy).

PIAS4_MOUSE
θ value	1.29861e-115 (rank : 8)	NC score	0.975825 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JM05, Q8R165	Gene names	Pias4, Piasg
Domain Architecture
Description	Protein inhibitor of activated STAT protein 4 (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) (PIASy).

ZIMP7_MOUSE
θ value	2.7842e-17 (rank : 9)	NC score	0.508280 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	566	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZIMP7_HUMAN
θ value	6.20254e-17 (rank : 10)	NC score	0.566147 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	290	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZIM10_HUMAN
θ value	1.99529e-15 (rank : 11)	NC score	0.482305 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	577	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZIM10_MOUSE
θ value	1.99529e-15 (rank : 12)	NC score	0.521541 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	430	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

DNMT2_HUMAN
θ value	0.813845 (rank : 13)	NC score	0.041328 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	O14717, O43669	Gene names	DNMT2
Domain Architecture
Description	tRNA (cytosine-5-)-methyltransferase (EC 2.1.1.29) (DNA (cytosine-5)- methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet).

UBP36_HUMAN
θ value	0.813845 (rank : 14)	NC score	0.011756 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	232	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

MSH5_MOUSE
θ value	1.06291 (rank : 15)	NC score	0.025678 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QUM7, Q9Z1Q6	Gene names	Msh5
Domain Architecture	No domain graphic available
Description	MutS protein homolog 5.

ZN250_MOUSE
θ value	1.06291 (rank : 16)	NC score	-0.001022 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	773	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TNU6, Q8BJ57	Gene names	Znf250, Zfp647, Znf647
Domain Architecture	No domain graphic available
Description	Zinc finger protein 250 (Zinc finger protein 647).

CB010_HUMAN
θ value	1.38821 (rank : 17)	NC score	0.045735 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z570, Q6ZN26	Gene names	C2orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf10.

ZN364_MOUSE
θ value	1.38821 (rank : 18)	NC score	0.051770 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	140	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D0C1, Q8R5A1, Q9D885	Gene names	Znf364, Zfp364
Domain Architecture
Description	Zinc finger protein 364 (Rabring 7).

VAX2_MOUSE
θ value	1.81305 (rank : 19)	NC score	0.008860 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	338	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTP9	Gene names	Vax2, Vex
Domain Architecture	No domain graphic available
Description	Ventral anterior homeobox 2 (Ventral retina homeodomain protein).

ZN364_HUMAN
θ value	1.81305 (rank : 20)	NC score	0.048357 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	140	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y4L5, Q5T2V9, Q7Z2J2	Gene names	ZNF364, RNF115
Domain Architecture	No domain graphic available
Description	Zinc finger protein 364 (Rabring 7) (RING finger protein 115).

SMO_MOUSE
θ value	2.36792 (rank : 21)	NC score	0.009327 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

EZH1_MOUSE
θ value	3.0926 (rank : 22)	NC score	0.008957 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

PDE9A_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.006752 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

CSN7B_HUMAN
θ value	4.03905 (rank : 24)	NC score	0.031490 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H9Q2, Q9H7V6	Gene names	COPS7B, CSN7B
Domain Architecture	No domain graphic available
Description	COP9 signalosome complex subunit 7b (Signalosome subunit 7b) (SGN7b) (JAB1-containing signalosome subunit 7b).

PF21B_MOUSE
θ value	4.03905 (rank : 25)	NC score	0.014072 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	278	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

CSN7B_MOUSE
θ value	5.27518 (rank : 26)	NC score	0.027000 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BV13, O88547, Q3TGG7, Q921G4	Gene names	Cops7b, Csn7b
Domain Architecture	No domain graphic available
Description	COP9 signalosome complex subunit 7b (Signalosome subunit 7b) (SGN7b) (JAB1-containing signalosome subunit 7b).

FARP2_HUMAN
θ value	5.27518 (rank : 27)	NC score	0.007408 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	240	Shared Neighborhood Hits	4
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

NR5A2_MOUSE
θ value	5.27518 (rank : 28)	NC score	0.004906 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

SYMPK_HUMAN
θ value	5.27518 (rank : 29)	NC score	0.020494 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

SYMPK_MOUSE
θ value	5.27518 (rank : 30)	NC score	0.020366 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

AT2C1_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.003162 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	P98194, O76005, Q86V72, Q86V73, Q8N6V1, Q8NCJ7	Gene names	ATP2C1, KIAA1347, PMR1L
Domain Architecture
Description	Calcium-transporting ATPase type 2C member 1 (EC 3.6.3.8) (ATPase 2C1) (ATP-dependent Ca(2+) pump PMR1).

SIN3B_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.010975 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	O75182, Q68GC2, Q6P4B8, Q8TB34, Q9BSC8	Gene names	SIN3B, KIAA0700
Domain Architecture
Description	Paired amphipathic helix protein Sin3b (Transcriptional corepressor Sin3b) (Histone deacetylase complex subunit Sin3b).

SIN3B_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.011097 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	Q62141, O54976, Q6A013, Q8VCB8, Q8VDZ5	Gene names	Sin3b, Kiaa0700
Domain Architecture
Description	Paired amphipathic helix protein Sin3b (Transcriptional corepressor Sin3b) (Histone deacetylase complex subunit Sin3b).

TIMD1_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.014129 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q5QNS5, Q7TPU2, Q8VIM1, Q8VIM2	Gene names	Havcr1, Tim1, Timd1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 homolog precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1).

TSH1_MOUSE
θ value	6.88961 (rank : 35)	NC score	0.004054 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	675	Shared Neighborhood Hits	3
SwissProt Accessions	Q5DTH5, Q6PE60, Q8VD19, Q9JLD5	Gene names	Tshz1, Kiaa4206, Sdccag33, Tsh1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog).

MRP5_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.003204 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	O15440, O14517, Q9UN85, Q9UNP5, Q9UQC3	Gene names	ABCC5, MRP5
Domain Architecture
Description	Multidrug resistance-associated protein 5 (ATP-binding cassette sub- family C member 5) (Multi-specific organic anion transporter-C) (MOAT- C) (pABC11) (SMRP).

Hits sorted by NC score

PIAS1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).

PIAS1_MOUSE
NC score	0.998917 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	27
SwissProt Accessions	O88907, Q8C6H5	Gene names	Pias1, Ddxbp1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (DEAD/H box-binding protein 1).

PIAS2_MOUSE
NC score	0.989106 (rank : 3)	θ value	7.49059e-172 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C5D8, O54987, Q8C384, Q8CDQ8, Q8K208, Q99JX5, Q9D5W7, Q9QZ63	Gene names	Pias2, Miz1, Piasx
Domain Architecture	No domain graphic available
Description	Protein inhibitor of activated STAT2 (Protein inhibitor of activated STAT x) (Msx-interacting zinc finger protein) (DAB2-interacting protein) (DIP) (Androgen receptor-interacting protein 3) (ARIP3).

PIAS2_HUMAN
NC score	0.989002 (rank : 4)	θ value	6.77497e-173 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	O75928, O75927, Q96BT5, Q96KE3	Gene names	PIAS2, PIASX
Domain Architecture	No domain graphic available
Description	Protein inhibitor of activated STAT2 (Protein inhibitor of activated STAT x) (Msx-interacting zinc finger protein) (Miz1) (DAB2-interacting protein) (DIP) (Androgen receptor-interacting protein 3) (ARIP3) (PIAS-NY protein).

PIAS3_HUMAN
NC score	0.987636 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	58	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6X2, Q9UFI3	Gene names	PIAS3
Domain Architecture
Description	Protein inhibitor of activated STAT protein 3.

PIAS3_MOUSE
NC score	0.986316 (rank : 6)	θ value	0 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	65	Shared Neighborhood Hits	14
SwissProt Accessions	O54714, Q80WF8, Q8R598	Gene names	Pias3
Domain Architecture
Description	Protein inhibitor of activated STAT protein 3.

PIAS4_HUMAN
NC score	0.975959 (rank : 7)	θ value	1.2549e-118 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N2W9, O75926, Q96G19, Q9UN16	Gene names	PIAS4, PIASG
Domain Architecture
Description	Protein inhibitor of activated STAT protein 4 (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) (PIASy).

PIAS4_MOUSE
NC score	0.975825 (rank : 8)	θ value	1.29861e-115 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JM05, Q8R165	Gene names	Pias4, Piasg
Domain Architecture
Description	Protein inhibitor of activated STAT protein 4 (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) (PIASy).

ZIMP7_HUMAN
NC score	0.566147 (rank : 9)	θ value	6.20254e-17 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	290	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZIM10_MOUSE
NC score	0.521541 (rank : 10)	θ value	1.99529e-15 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	430	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZIMP7_MOUSE
NC score	0.508280 (rank : 11)	θ value	2.7842e-17 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	566	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZIM10_HUMAN
NC score	0.482305 (rank : 12)	θ value	1.99529e-15 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	577	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZN364_MOUSE
NC score	0.051770 (rank : 13)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	140	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D0C1, Q8R5A1, Q9D885	Gene names	Znf364, Zfp364
Domain Architecture
Description	Zinc finger protein 364 (Rabring 7).

ZN364_HUMAN
NC score	0.048357 (rank : 14)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	140	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y4L5, Q5T2V9, Q7Z2J2	Gene names	ZNF364, RNF115
Domain Architecture	No domain graphic available
Description	Zinc finger protein 364 (Rabring 7) (RING finger protein 115).

CB010_HUMAN
NC score	0.045735 (rank : 15)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z570, Q6ZN26	Gene names	C2orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf10.

DNMT2_HUMAN
NC score	0.041328 (rank : 16)	θ value	0.813845 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	O14717, O43669	Gene names	DNMT2
Domain Architecture
Description	tRNA (cytosine-5-)-methyltransferase (EC 2.1.1.29) (DNA (cytosine-5)- methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet).

CSN7B_HUMAN
NC score	0.031490 (rank : 17)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H9Q2, Q9H7V6	Gene names	COPS7B, CSN7B
Domain Architecture	No domain graphic available
Description	COP9 signalosome complex subunit 7b (Signalosome subunit 7b) (SGN7b) (JAB1-containing signalosome subunit 7b).

CSN7B_MOUSE
NC score	0.027000 (rank : 18)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BV13, O88547, Q3TGG7, Q921G4	Gene names	Cops7b, Csn7b
Domain Architecture	No domain graphic available
Description	COP9 signalosome complex subunit 7b (Signalosome subunit 7b) (SGN7b) (JAB1-containing signalosome subunit 7b).

MSH5_MOUSE
NC score	0.025678 (rank : 19)	θ value	1.06291 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QUM7, Q9Z1Q6	Gene names	Msh5
Domain Architecture	No domain graphic available
Description	MutS protein homolog 5.

SYMPK_HUMAN
NC score	0.020494 (rank : 20)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

SYMPK_MOUSE
NC score	0.020366 (rank : 21)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

TIMD1_MOUSE
NC score	0.014129 (rank : 22)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q5QNS5, Q7TPU2, Q8VIM1, Q8VIM2	Gene names	Havcr1, Tim1, Timd1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 homolog precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1).

PF21B_MOUSE
NC score	0.014072 (rank : 23)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	278	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

UBP36_HUMAN
NC score	0.011756 (rank : 24)	θ value	0.813845 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	232	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

SIN3B_MOUSE
NC score	0.011097 (rank : 25)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	Q62141, O54976, Q6A013, Q8VCB8, Q8VDZ5	Gene names	Sin3b, Kiaa0700
Domain Architecture
Description	Paired amphipathic helix protein Sin3b (Transcriptional corepressor Sin3b) (Histone deacetylase complex subunit Sin3b).

SIN3B_HUMAN
NC score	0.010975 (rank : 26)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	O75182, Q68GC2, Q6P4B8, Q8TB34, Q9BSC8	Gene names	SIN3B, KIAA0700
Domain Architecture
Description	Paired amphipathic helix protein Sin3b (Transcriptional corepressor Sin3b) (Histone deacetylase complex subunit Sin3b).

SMO_MOUSE
NC score	0.009327 (rank : 27)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

EZH1_MOUSE
NC score	0.008957 (rank : 28)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

VAX2_MOUSE
NC score	0.008860 (rank : 29)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	338	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTP9	Gene names	Vax2, Vex
Domain Architecture	No domain graphic available
Description	Ventral anterior homeobox 2 (Ventral retina homeodomain protein).

FARP2_HUMAN
NC score	0.007408 (rank : 30)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	240	Shared Neighborhood Hits	4
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PDE9A_HUMAN
NC score	0.006752 (rank : 31)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

NR5A2_MOUSE
NC score	0.004906 (rank : 32)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

TSH1_MOUSE
NC score	0.004054 (rank : 33)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	675	Shared Neighborhood Hits	3
SwissProt Accessions	Q5DTH5, Q6PE60, Q8VD19, Q9JLD5	Gene names	Tshz1, Kiaa4206, Sdccag33, Tsh1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog).

MRP5_HUMAN
NC score	0.003204 (rank : 34)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	O15440, O14517, Q9UN85, Q9UNP5, Q9UQC3	Gene names	ABCC5, MRP5
Domain Architecture
Description	Multidrug resistance-associated protein 5 (ATP-binding cassette sub- family C member 5) (Multi-specific organic anion transporter-C) (MOAT- C) (pABC11) (SMRP).

AT2C1_HUMAN
NC score	0.003162 (rank : 35)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	P98194, O76005, Q86V72, Q86V73, Q8N6V1, Q8NCJ7	Gene names	ATP2C1, KIAA1347, PMR1L
Domain Architecture
Description	Calcium-transporting ATPase type 2C member 1 (EC 3.6.3.8) (ATPase 2C1) (ATP-dependent Ca(2+) pump PMR1).

ZN250_MOUSE
NC score	-0.001022 (rank : 36)	θ value	1.06291 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	773	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TNU6, Q8BJ57	Gene names	Znf250, Zfp647, Znf647
Domain Architecture	No domain graphic available
Description	Zinc finger protein 250 (Zinc finger protein 647).