Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : AHI1_HUMAN

For an explanation of this page, click here

AHI1_HUMAN
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AHI1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	537	Target Neighborhood Hits	537	Shared Neighborhood Hits	537
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	0 (rank : 2)	NC score	0.976895 (rank : 2)
Query Neighborhood Hits	537	Target Neighborhood Hits	496	Shared Neighborhood Hits	432
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

WDR5_HUMAN
θ value	1.80048e-24 (rank : 3)	NC score	0.643694 (rank : 3)
Query Neighborhood Hits	537	Target Neighborhood Hits	341	Shared Neighborhood Hits	226
SwissProt Accessions	P61964, Q91VA5, Q9NWX7, Q9UGP9	Gene names	WDR5, BIG3
Domain Architecture
Description	WD repeat protein 5 (BMP2-induced 3-kb gene protein).

WDR5_MOUSE
θ value	1.80048e-24 (rank : 4)	NC score	0.643694 (rank : 4)
Query Neighborhood Hits	537	Target Neighborhood Hits	341	Shared Neighborhood Hits	226
SwissProt Accessions	P61965, Q91VA5, Q922C9, Q9NWX7, Q9UGP9	Gene names	Wdr5, Big, Big3
Domain Architecture
Description	WD repeat protein 5 (BMP2-induced 3-kb gene protein) (WD repeat protein BIG-3).

WDR57_HUMAN
θ value	5.8054e-15 (rank : 5)	NC score	0.623127 (rank : 5)
Query Neighborhood Hits	537	Target Neighborhood Hits	322	Shared Neighborhood Hits	227
SwissProt Accessions	Q96DI7, O75938, O95320	Gene names	WDR57, PRP8BP, SFP38
Domain Architecture	No domain graphic available
Description	WD repeat protein 57 (Prp8-binding protein) (hPRP8BP) (U5 snRNP- specific 40 kDa protein) (38 kDa-splicing factor).

WDR57_MOUSE
θ value	2.20605e-14 (rank : 6)	NC score	0.622024 (rank : 7)
Query Neighborhood Hits	537	Target Neighborhood Hits	323	Shared Neighborhood Hits	227
SwissProt Accessions	Q6PE01, Q3TEJ3, Q9DCX3	Gene names	Wdr57
Domain Architecture	No domain graphic available
Description	WD repeat protein 57.

A16L1_HUMAN
θ value	5.43371e-13 (rank : 7)	NC score	0.586898 (rank : 45)
Query Neighborhood Hits	537	Target Neighborhood Hits	664	Shared Neighborhood Hits	235
SwissProt Accessions	Q676U5, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619	Gene names	ATG16L1, APG16L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

SMU1_HUMAN
θ value	9.26847e-13 (rank : 8)	NC score	0.611238 (rank : 10)
Query Neighborhood Hits	537	Target Neighborhood Hits	311	Shared Neighborhood Hits	223
SwissProt Accessions	Q2TAY7, Q9BU59, Q9HA96, Q9NVD1	Gene names	SMU1
Domain Architecture	No domain graphic available
Description	Smu-1 suppressor of mec-8 and unc-52 protein homolog.

SMU1_MOUSE
θ value	9.26847e-13 (rank : 9)	NC score	0.611238 (rank : 11)
Query Neighborhood Hits	537	Target Neighborhood Hits	311	Shared Neighborhood Hits	223
SwissProt Accessions	Q3UKJ7, Q6PFR6, Q8BMY4, Q9D1I8, Q9JJ70	Gene names	Smu1
Domain Architecture	No domain graphic available
Description	Smu-1 suppressor of mec-8 and unc-52 protein homolog.

A16L1_MOUSE
θ value	1.02475e-11 (rank : 10)	NC score	0.569006 (rank : 76)
Query Neighborhood Hits	537	Target Neighborhood Hits	776	Shared Neighborhood Hits	237
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

WSB2_HUMAN
θ value	2.28291e-11 (rank : 11)	NC score	0.589458 (rank : 33)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	218
SwissProt Accessions	Q9NYS7, Q9NRX9	Gene names	WSB2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein).

WSB2_MOUSE
θ value	5.08577e-11 (rank : 12)	NC score	0.585714 (rank : 47)
Query Neighborhood Hits	537	Target Neighborhood Hits	306	Shared Neighborhood Hits	218
SwissProt Accessions	O54929, Q9R1M8	Gene names	Wsb2, Swip2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (SOCS box- containing WD protein SWiP-2).

KTNB1_HUMAN
θ value	6.64225e-11 (rank : 13)	NC score	0.599437 (rank : 20)
Query Neighborhood Hits	537	Target Neighborhood Hits	349	Shared Neighborhood Hits	229
SwissProt Accessions	Q9BVA0, O60620	Gene names	KATNB1
Domain Architecture	No domain graphic available
Description	Katanin p80 WD40-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin).

KTNB1_MOUSE
θ value	6.64225e-11 (rank : 14)	NC score	0.598969 (rank : 21)
Query Neighborhood Hits	537	Target Neighborhood Hits	356	Shared Neighborhood Hits	227
SwissProt Accessions	Q8BG40, Q8CD18, Q8R1J0, Q9CWV2	Gene names	Katnb1
Domain Architecture	No domain graphic available
Description	Katanin p80 WD40-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin).

WD51A_MOUSE
θ value	6.64225e-11 (rank : 15)	NC score	0.603641 (rank : 18)
Query Neighborhood Hits	537	Target Neighborhood Hits	342	Shared Neighborhood Hits	225
SwissProt Accessions	Q8JZX3, Q9CY09	Gene names	Wdr51a
Domain Architecture	No domain graphic available
Description	WD repeat protein 51A.

WD51B_HUMAN
θ value	6.64225e-11 (rank : 16)	NC score	0.606261 (rank : 16)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	228
SwissProt Accessions	Q8TC44	Gene names	WDR51B
Domain Architecture	No domain graphic available
Description	WD repeat protein 51B.

MORG1_MOUSE
θ value	1.47974e-10 (rank : 17)	NC score	0.622915 (rank : 6)
Query Neighborhood Hits	537	Target Neighborhood Hits	281	Shared Neighborhood Hits	214
SwissProt Accessions	Q9DAJ4, Q505C2, Q8VEB7, Q99JX9, Q9D235	Gene names	Morg1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase organizer 1 (MAPK organizer 1).

WDR69_HUMAN
θ value	1.47974e-10 (rank : 18)	NC score	0.610733 (rank : 12)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	223
SwissProt Accessions	Q8N136, Q6ZRY1, Q8N776	Gene names	WDR69
Domain Architecture	No domain graphic available
Description	WD repeat protein 69.

GBB3_HUMAN
θ value	7.34386e-10 (rank : 19)	NC score	0.579885 (rank : 55)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	215
SwissProt Accessions	P16520, Q9BQC0	Gene names	GNB3
Domain Architecture
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 3 (Transducin beta chain 3).

WD51A_HUMAN
θ value	7.34386e-10 (rank : 20)	NC score	0.602672 (rank : 19)
Query Neighborhood Hits	537	Target Neighborhood Hits	337	Shared Neighborhood Hits	225
SwissProt Accessions	Q8NBT0, Q2TAK6, Q96IK6, Q9UFJ8	Gene names	WDR51A
Domain Architecture	No domain graphic available
Description	WD repeat protein 51A.

GBB3_MOUSE
θ value	9.59137e-10 (rank : 21)	NC score	0.579938 (rank : 54)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	216
SwissProt Accessions	Q61011	Gene names	Gnb3
Domain Architecture
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 3 (Transducin beta chain 3).

WD51B_MOUSE
θ value	1.25267e-09 (rank : 22)	NC score	0.607700 (rank : 15)
Query Neighborhood Hits	537	Target Neighborhood Hits	321	Shared Neighborhood Hits	228
SwissProt Accessions	Q8BHD1	Gene names	Wdr51b
Domain Architecture	No domain graphic available
Description	WD repeat protein 51B.

RBBP5_HUMAN
θ value	1.63604e-09 (rank : 23)	NC score	0.544530 (rank : 98)
Query Neighborhood Hits	537	Target Neighborhood Hits	372	Shared Neighborhood Hits	177
SwissProt Accessions	Q15291	Gene names	RBBP5, RBQ3
Domain Architecture
Description	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3).

TBL1X_HUMAN
θ value	2.79066e-09 (rank : 24)	NC score	0.588208 (rank : 37)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	222
SwissProt Accessions	O60907, Q86UY2	Gene names	TBL1X, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein) (Transducin-beta-like 1, X-linked) (SMAP55).

MORG1_HUMAN
θ value	3.64472e-09 (rank : 25)	NC score	0.617261 (rank : 8)
Query Neighborhood Hits	537	Target Neighborhood Hits	280	Shared Neighborhood Hits	213
SwissProt Accessions	Q9BRX9, Q53FT6	Gene names	MORG1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase organizer 1 (MAPK organizer 1).

GBB2_HUMAN
θ value	4.76016e-09 (rank : 26)	NC score	0.582045 (rank : 48)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	218
SwissProt Accessions	P62879, P11016, P54312	Gene names	GNB2
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit).

GBB2_MOUSE
θ value	4.76016e-09 (rank : 27)	NC score	0.582045 (rank : 49)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	218
SwissProt Accessions	P62880, P11016, P54312	Gene names	Gnb2
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit).

ITSN2_HUMAN
θ value	4.76016e-09 (rank : 28)	NC score	0.326941 (rank : 312)
Query Neighborhood Hits	537	Target Neighborhood Hits	1173	Shared Neighborhood Hits	243
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

GBLP_HUMAN
θ value	8.11959e-09 (rank : 29)	NC score	0.607727 (rank : 13)
Query Neighborhood Hits	537	Target Neighborhood Hits	316	Shared Neighborhood Hits	224
SwissProt Accessions	P63244, P25388, P99049	Gene names	GNB2L1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 2-like 1 (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Receptor of activated protein kinase C 1) (RACK1) (Receptor for activated C kinase).

GBLP_MOUSE
θ value	8.11959e-09 (rank : 30)	NC score	0.607727 (rank : 14)
Query Neighborhood Hits	537	Target Neighborhood Hits	316	Shared Neighborhood Hits	224
SwissProt Accessions	P68040, P25388, P99049	Gene names	Gnb2l1, Gnb2-rs1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 2-like 1 (Receptor of activated protein kinase C 1) (RACK1) (Receptor for activated C kinase) (p205) (12-3).

ITSN1_HUMAN
θ value	1.06045e-08 (rank : 31)	NC score	0.303179 (rank : 331)
Query Neighborhood Hits	537	Target Neighborhood Hits	1757	Shared Neighborhood Hits	255
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SPG16_HUMAN
θ value	1.06045e-08 (rank : 32)	NC score	0.613869 (rank : 9)
Query Neighborhood Hits	537	Target Neighborhood Hits	361	Shared Neighborhood Hits	227
SwissProt Accessions	Q8N0X2, Q658W1, Q68DB3, Q6I9Z6, Q8N9C7, Q9H601	Gene names	SPAG16, PF20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

TBL1Y_HUMAN
θ value	1.06045e-08 (rank : 33)	NC score	0.586435 (rank : 46)
Query Neighborhood Hits	537	Target Neighborhood Hits	331	Shared Neighborhood Hits	225
SwissProt Accessions	Q9BQ87	Gene names	TBL1Y, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1Y (Transducin beta-like 1Y protein) (Transducin-beta-like 1, Y-linked).

GBB4_MOUSE
θ value	1.38499e-08 (rank : 34)	NC score	0.577193 (rank : 60)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	216
SwissProt Accessions	P29387, Q3TJJ1, Q8R475, Q9JHX8	Gene names	Gnb4
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 4 (Transducin beta chain 4).

ITSN1_MOUSE
θ value	1.80886e-08 (rank : 35)	NC score	0.302708 (rank : 332)
Query Neighborhood Hits	537	Target Neighborhood Hits	1669	Shared Neighborhood Hits	250
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PLCG2_HUMAN
θ value	1.80886e-08 (rank : 36)	NC score	0.324446 (rank : 314)
Query Neighborhood Hits	537	Target Neighborhood Hits	280	Shared Neighborhood Hits	162
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

TBLX_MOUSE
θ value	1.80886e-08 (rank : 37)	NC score	0.587383 (rank : 40)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	226
SwissProt Accessions	Q9QXE7, Q8BMM0, Q8BYQ4, Q8C0A1	Gene names	Tbl1x, Tbl1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein).

ITSN2_MOUSE
θ value	3.08544e-08 (rank : 38)	NC score	0.309279 (rank : 327)
Query Neighborhood Hits	537	Target Neighborhood Hits	1371	Shared Neighborhood Hits	242
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

COPA_HUMAN
θ value	4.0297e-08 (rank : 39)	NC score	0.577894 (rank : 59)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	215
SwissProt Accessions	P53621	Gene names	COPA
Domain Architecture
Description	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEPCOP) (HEP- COP) [Contains: Xenin (Xenopsin-related peptide); Proxenin].

PRP4_MOUSE
θ value	4.0297e-08 (rank : 40)	NC score	0.595410 (rank : 28)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	222
SwissProt Accessions	Q9DAW6	Gene names	Prpf4
Domain Architecture	No domain graphic available
Description	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4).

TBL1R_HUMAN
θ value	4.0297e-08 (rank : 41)	NC score	0.587561 (rank : 39)
Query Neighborhood Hits	537	Target Neighborhood Hits	327	Shared Neighborhood Hits	223
SwissProt Accessions	Q9BZK7, Q9H2I1, Q9H9A1	Gene names	TBL1XR1, IRA1, TBLR1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1).

TBL1R_MOUSE
θ value	4.0297e-08 (rank : 42)	NC score	0.587690 (rank : 38)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	223
SwissProt Accessions	Q8BHJ5, Q3UWL6, Q8CBG4, Q8VEG3, Q9EQD4	Gene names	Tbl1xr1, Ira1, Tblr1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1).

PRP4_HUMAN
θ value	6.87365e-08 (rank : 43)	NC score	0.595519 (rank : 27)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	224
SwissProt Accessions	O43172, O43445, O43864, Q96DG2, Q96IK4	Gene names	PRPF4, PRP4
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) (hPrp4).

FBXW7_HUMAN
θ value	8.97725e-08 (rank : 44)	NC score	0.578002 (rank : 57)
Query Neighborhood Hits	537	Target Neighborhood Hits	433	Shared Neighborhood Hits	229
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

GBB4_HUMAN
θ value	8.97725e-08 (rank : 45)	NC score	0.575838 (rank : 62)
Query Neighborhood Hits	537	Target Neighborhood Hits	288	Shared Neighborhood Hits	217
SwissProt Accessions	Q9HAV0	Gene names	GNB4
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 4 (Transducin beta chain 4).

SPG16_MOUSE
θ value	8.97725e-08 (rank : 46)	NC score	0.604692 (rank : 17)
Query Neighborhood Hits	537	Target Neighborhood Hits	377	Shared Neighborhood Hits	229
SwissProt Accessions	Q8K450, Q8C450, Q9CPU8, Q9D522	Gene names	Spag16, Pf20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

APAF_MOUSE
θ value	1.17247e-07 (rank : 47)	NC score	0.580818 (rank : 52)
Query Neighborhood Hits	537	Target Neighborhood Hits	343	Shared Neighborhood Hits	224
SwissProt Accessions	O88879	Gene names	Apaf1
Domain Architecture
Description	Apoptotic protease-activating factor 1 (Apaf-1).

NLE1_HUMAN
θ value	1.17247e-07 (rank : 48)	NC score	0.597270 (rank : 25)
Query Neighborhood Hits	537	Target Neighborhood Hits	334	Shared Neighborhood Hits	227
SwissProt Accessions	Q9NVX2, O60868, Q9BU54	Gene names	NLE1
Domain Architecture
Description	Notchless homolog 1.

NLE1_MOUSE
θ value	1.17247e-07 (rank : 49)	NC score	0.596982 (rank : 26)
Query Neighborhood Hits	537	Target Neighborhood Hits	332	Shared Neighborhood Hits	227
SwissProt Accessions	Q8VEJ4	Gene names	Nle1
Domain Architecture
Description	Notchless homolog 1.

ABI2_HUMAN
θ value	1.53129e-07 (rank : 50)	NC score	0.438987 (rank : 182)
Query Neighborhood Hits	537	Target Neighborhood Hits	350	Shared Neighborhood Hits	186
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	1.53129e-07 (rank : 51)	NC score	0.443193 (rank : 173)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	184
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

BRWD1_HUMAN
θ value	1.99992e-07 (rank : 52)	NC score	0.535522 (rank : 104)
Query Neighborhood Hits	537	Target Neighborhood Hits	448	Shared Neighborhood Hits	229
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

STRAP_HUMAN
θ value	1.99992e-07 (rank : 53)	NC score	0.591549 (rank : 30)
Query Neighborhood Hits	537	Target Neighborhood Hits	272	Shared Neighborhood Hits	214
SwissProt Accessions	Q9Y3F4, Q9UQC8	Gene names	STRAP, MAWD, UNRIP
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein) (WD-40 repeat protein PT-WD) (MAP activator with WD repeats).

TAF5_HUMAN
θ value	2.61198e-07 (rank : 54)	NC score	0.593337 (rank : 29)
Query Neighborhood Hits	537	Target Neighborhood Hits	352	Shared Neighborhood Hits	228
SwissProt Accessions	Q15542, Q86UZ7, Q9Y4K5	Gene names	TAF5, TAF2D
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

TAF5_MOUSE
θ value	2.61198e-07 (rank : 55)	NC score	0.591468 (rank : 31)
Query Neighborhood Hits	537	Target Neighborhood Hits	366	Shared Neighborhood Hits	228
SwissProt Accessions	Q8C092, Q8BTR2	Gene names	Taf5
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

TBL3_HUMAN
θ value	2.61198e-07 (rank : 56)	NC score	0.597598 (rank : 24)
Query Neighborhood Hits	537	Target Neighborhood Hits	286	Shared Neighborhood Hits	212
SwissProt Accessions	Q12788	Gene names	TBL3, SAZD
Domain Architecture
Description	WD repeat protein SAZD (Transducin beta-like 3 protein).

FBXW7_MOUSE
θ value	3.41135e-07 (rank : 57)	NC score	0.578637 (rank : 56)
Query Neighborhood Hits	537	Target Neighborhood Hits	365	Shared Neighborhood Hits	224
SwissProt Accessions	Q8VBV4, Q8CCS5, Q8VHP4	Gene names	Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).

STRAP_MOUSE
θ value	3.41135e-07 (rank : 58)	NC score	0.590220 (rank : 32)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	213
SwissProt Accessions	Q9Z1Z2	Gene names	Strap, Unrip
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein).

GBB1_HUMAN
θ value	4.45536e-07 (rank : 59)	NC score	0.575480 (rank : 64)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	215
SwissProt Accessions	P62873, P04697, P04901	Gene names	GNB1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 1 (Transducin beta chain 1).

GBB1_MOUSE
θ value	4.45536e-07 (rank : 60)	NC score	0.575480 (rank : 65)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	215
SwissProt Accessions	P62874, P04697, P04901	Gene names	Gnb1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 1 (Transducin beta chain 1).

BRWD1_MOUSE
θ value	5.81887e-07 (rank : 61)	NC score	0.534361 (rank : 105)
Query Neighborhood Hits	537	Target Neighborhood Hits	478	Shared Neighborhood Hits	227
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

COR2A_MOUSE
θ value	5.81887e-07 (rank : 62)	NC score	0.407119 (rank : 215)
Query Neighborhood Hits	537	Target Neighborhood Hits	204	Shared Neighborhood Hits	156
SwissProt Accessions	Q8C0P5, Q3U6H8, Q8BW42	Gene names	Coro2a
Domain Architecture	No domain graphic available
Description	Coronin-2A.

U3IP2_MOUSE
θ value	5.81887e-07 (rank : 63)	NC score	0.565706 (rank : 79)
Query Neighborhood Hits	537	Target Neighborhood Hits	312	Shared Neighborhood Hits	215
SwissProt Accessions	Q91WM3, Q8CFB7	Gene names	Rnu3ip2, U3-55k
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

PRP17_HUMAN
θ value	7.59969e-07 (rank : 64)	NC score	0.598388 (rank : 23)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	217
SwissProt Accessions	O60508, O75471, Q9UPG1	Gene names	CDC40, PRP17
Domain Architecture
Description	Pre-mRNA-splicing factor PRP17 (hPRP17) (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3).

PRP17_MOUSE
θ value	9.92553e-07 (rank : 65)	NC score	0.598662 (rank : 22)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	216
SwissProt Accessions	Q9DC48	Gene names	Cdc40, Prp17
Domain Architecture
Description	Pre-mRNA-splicing factor PRP17 (Cell division cycle 40 homolog).

WDR39_HUMAN
θ value	9.92553e-07 (rank : 66)	NC score	0.581223 (rank : 51)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	214
SwissProt Accessions	O76071	Gene names	WDR39, CIAO1
Domain Architecture
Description	WD repeat protein 39 (Ciao 1 protein).

M3K10_HUMAN
θ value	1.29631e-06 (rank : 67)	NC score	0.128496 (rank : 490)
Query Neighborhood Hits	537	Target Neighborhood Hits	1071	Shared Neighborhood Hits	169
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

TAF5L_HUMAN
θ value	1.69304e-06 (rank : 68)	NC score	0.588636 (rank : 35)
Query Neighborhood Hits	537	Target Neighborhood Hits	330	Shared Neighborhood Hits	225
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

U3IP2_HUMAN
θ value	1.69304e-06 (rank : 69)	NC score	0.567071 (rank : 78)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	215
SwissProt Accessions	O43818, Q8IZ30	Gene names	RNU3IP2, U355K
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

ASPP1_MOUSE
θ value	2.21117e-06 (rank : 70)	NC score	0.235806 (rank : 377)
Query Neighborhood Hits	537	Target Neighborhood Hits	1244	Shared Neighborhood Hits	197
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

FYN_HUMAN
θ value	2.21117e-06 (rank : 71)	NC score	0.170058 (rank : 436)
Query Neighborhood Hits	537	Target Neighborhood Hits	1078	Shared Neighborhood Hits	195
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	2.21117e-06 (rank : 72)	NC score	0.173005 (rank : 432)
Query Neighborhood Hits	537	Target Neighborhood Hits	1073	Shared Neighborhood Hits	195
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

WDR17_HUMAN
θ value	2.21117e-06 (rank : 73)	NC score	0.577933 (rank : 58)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	218
SwissProt Accessions	Q8IZU2	Gene names	WDR17
Domain Architecture
Description	WD repeat protein 17.

WDR4_MOUSE
θ value	2.88788e-06 (rank : 74)	NC score	0.370418 (rank : 264)
Query Neighborhood Hits	537	Target Neighborhood Hits	136	Shared Neighborhood Hits	118
SwissProt Accessions	Q9EP82	Gene names	Wdr4
Domain Architecture
Description	WD repeat protein 4.

COR2B_MOUSE
θ value	3.77169e-06 (rank : 75)	NC score	0.440038 (rank : 178)
Query Neighborhood Hits	537	Target Neighborhood Hits	235	Shared Neighborhood Hits	183
SwissProt Accessions	Q8BH44, Q6P5U9	Gene names	Coro2b
Domain Architecture	No domain graphic available
Description	Coronin-2B.

STAM1_MOUSE
θ value	3.77169e-06 (rank : 76)	NC score	0.404865 (rank : 219)
Query Neighborhood Hits	537	Target Neighborhood Hits	273	Shared Neighborhood Hits	190
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

WDHD1_MOUSE
θ value	3.77169e-06 (rank : 77)	NC score	0.505176 (rank : 119)
Query Neighborhood Hits	537	Target Neighborhood Hits	414	Shared Neighborhood Hits	217
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

YES_HUMAN
θ value	3.77169e-06 (rank : 78)	NC score	0.169839 (rank : 438)
Query Neighborhood Hits	537	Target Neighborhood Hits	1059	Shared Neighborhood Hits	192
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

M3K11_HUMAN
θ value	4.92598e-06 (rank : 79)	NC score	0.140029 (rank : 471)
Query Neighborhood Hits	537	Target Neighborhood Hits	1136	Shared Neighborhood Hits	193
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TAF5L_MOUSE
θ value	4.92598e-06 (rank : 80)	NC score	0.589047 (rank : 34)
Query Neighborhood Hits	537	Target Neighborhood Hits	337	Shared Neighborhood Hits	225
SwissProt Accessions	Q91WQ5, Q8BTL5	Gene names	Taf5l, Paf65b
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

ABI1_HUMAN
θ value	6.43352e-06 (rank : 81)	NC score	0.406127 (rank : 218)
Query Neighborhood Hits	537	Target Neighborhood Hits	257	Shared Neighborhood Hits	176
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

COR2A_HUMAN
θ value	6.43352e-06 (rank : 82)	NC score	0.414179 (rank : 202)
Query Neighborhood Hits	537	Target Neighborhood Hits	214	Shared Neighborhood Hits	167
SwissProt Accessions	Q92828, Q92829, Q9BWS5	Gene names	CORO2A, IR10, WDR2
Domain Architecture
Description	Coronin-2A (WD repeat-containing protein 2) (IR10).

COR2B_HUMAN
θ value	6.43352e-06 (rank : 83)	NC score	0.437337 (rank : 186)
Query Neighborhood Hits	537	Target Neighborhood Hits	233	Shared Neighborhood Hits	181
SwissProt Accessions	Q9UQ03, O94767, Q8TAN1	Gene names	CORO2B, KIAA0925
Domain Architecture
Description	Coronin-2B (Coronin-like protein C) (ClipinC) (Protein FC96).

M3KL4_HUMAN
θ value	8.40245e-06 (rank : 84)	NC score	0.148538 (rank : 460)
Query Neighborhood Hits	537	Target Neighborhood Hits	1087	Shared Neighborhood Hits	185
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SH3K1_HUMAN
θ value	8.40245e-06 (rank : 85)	NC score	0.441673 (rank : 176)
Query Neighborhood Hits	537	Target Neighborhood Hits	341	Shared Neighborhood Hits	198
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

STAM1_HUMAN
θ value	8.40245e-06 (rank : 86)	NC score	0.403497 (rank : 223)
Query Neighborhood Hits	537	Target Neighborhood Hits	271	Shared Neighborhood Hits	193
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

WDR13_HUMAN
θ value	8.40245e-06 (rank : 87)	NC score	0.467708 (rank : 151)
Query Neighborhood Hits	537	Target Neighborhood Hits	186	Shared Neighborhood Hits	163
SwissProt Accessions	Q9H1Z4, Q9BUL7, Q9NWW4	Gene names	WDR13
Domain Architecture
Description	WD repeat protein 13.

YES_MOUSE
θ value	8.40245e-06 (rank : 88)	NC score	0.169527 (rank : 439)
Query Neighborhood Hits	537	Target Neighborhood Hits	1052	Shared Neighborhood Hits	192
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHG6_HUMAN
θ value	1.09739e-05 (rank : 89)	NC score	0.364838 (rank : 278)
Query Neighborhood Hits	537	Target Neighborhood Hits	376	Shared Neighborhood Hits	187
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

GRAP2_HUMAN
θ value	1.09739e-05 (rank : 90)	NC score	0.439139 (rank : 180)
Query Neighborhood Hits	537	Target Neighborhood Hits	304	Shared Neighborhood Hits	196
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PLCG1_MOUSE
θ value	1.09739e-05 (rank : 91)	NC score	0.314031 (rank : 323)
Query Neighborhood Hits	537	Target Neighborhood Hits	314	Shared Neighborhood Hits	168
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

WDR4_HUMAN
θ value	1.09739e-05 (rank : 92)	NC score	0.376183 (rank : 254)
Query Neighborhood Hits	537	Target Neighborhood Hits	145	Shared Neighborhood Hits	126
SwissProt Accessions	P57081, Q9HCR3	Gene names	WDR4
Domain Architecture
Description	WD repeat protein 4.

ABI1_MOUSE
θ value	1.43324e-05 (rank : 93)	NC score	0.416310 (rank : 201)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	177
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

BTK_HUMAN
θ value	1.43324e-05 (rank : 94)	NC score	0.156398 (rank : 450)
Query Neighborhood Hits	537	Target Neighborhood Hits	1026	Shared Neighborhood Hits	189
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FGR_MOUSE
θ value	1.43324e-05 (rank : 95)	NC score	0.169420 (rank : 440)
Query Neighborhood Hits	537	Target Neighborhood Hits	1069	Shared Neighborhood Hits	189
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

PLCG1_HUMAN
θ value	1.43324e-05 (rank : 96)	NC score	0.305649 (rank : 330)
Query Neighborhood Hits	537	Target Neighborhood Hits	293	Shared Neighborhood Hits	161
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G2_MOUSE
θ value	1.43324e-05 (rank : 97)	NC score	0.382271 (rank : 248)
Query Neighborhood Hits	537	Target Neighborhood Hits	319	Shared Neighborhood Hits	179
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

STAC_HUMAN
θ value	1.43324e-05 (rank : 98)	NC score	0.404455 (rank : 220)
Query Neighborhood Hits	537	Target Neighborhood Hits	276	Shared Neighborhood Hits	184
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

THOC3_HUMAN
θ value	1.43324e-05 (rank : 99)	NC score	0.581651 (rank : 50)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	221
SwissProt Accessions	Q96J01	Gene names	THOC3
Domain Architecture
Description	THO complex subunit 3 (Tho3) (TEX1 homolog).

UTP15_MOUSE
θ value	1.43324e-05 (rank : 100)	NC score	0.568134 (rank : 77)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	216
SwissProt Accessions	Q8C7V3, Q3TRG8, Q8K231	Gene names	Utp15
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 15 homolog (Src-associated protein SAW).

WDHD1_HUMAN
θ value	1.43324e-05 (rank : 101)	NC score	0.499192 (rank : 128)
Query Neighborhood Hits	537	Target Neighborhood Hits	342	Shared Neighborhood Hits	190
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

WDR18_HUMAN
θ value	1.43324e-05 (rank : 102)	NC score	0.497945 (rank : 131)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	198
SwissProt Accessions	Q9BV38, O60390, Q9BWR2	Gene names	WDR18
Domain Architecture
Description	WD repeat protein 18.

WDR33_HUMAN
θ value	1.43324e-05 (rank : 103)	NC score	0.510050 (rank : 111)
Query Neighborhood Hits	537	Target Neighborhood Hits	638	Shared Neighborhood Hits	229
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

CD2AP_MOUSE
θ value	1.87187e-05 (rank : 104)	NC score	0.446393 (rank : 171)
Query Neighborhood Hits	537	Target Neighborhood Hits	336	Shared Neighborhood Hits	200
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

IF122_HUMAN
θ value	1.87187e-05 (rank : 105)	NC score	0.498199 (rank : 129)
Query Neighborhood Hits	537	Target Neighborhood Hits	244	Shared Neighborhood Hits	192
SwissProt Accessions	Q9HBG6	Gene names	IFT122, WDR10, WDR140
Domain Architecture
Description	Intraflagellar transport 122 homolog (WD repeat protein 10).

WDR37_HUMAN
θ value	1.87187e-05 (rank : 106)	NC score	0.563962 (rank : 81)
Query Neighborhood Hits	537	Target Neighborhood Hits	303	Shared Neighborhood Hits	210
SwissProt Accessions	Q9Y2I8, Q5SW03, Q9NTJ6	Gene names	WDR37, KIAA0982
Domain Architecture
Description	WD repeat protein 37.

WSB1_MOUSE
θ value	1.87187e-05 (rank : 107)	NC score	0.575861 (rank : 61)
Query Neighborhood Hits	537	Target Neighborhood Hits	313	Shared Neighborhood Hits	214
SwissProt Accessions	O54927	Gene names	Wsb1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1).

BLK_HUMAN
θ value	2.44474e-05 (rank : 108)	NC score	0.146199 (rank : 461)
Query Neighborhood Hits	537	Target Neighborhood Hits	994	Shared Neighborhood Hits	156
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

GRAP_HUMAN
θ value	2.44474e-05 (rank : 109)	NC score	0.430671 (rank : 193)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	201
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SRC_HUMAN
θ value	2.44474e-05 (rank : 110)	NC score	0.165260 (rank : 444)
Query Neighborhood Hits	537	Target Neighborhood Hits	1058	Shared Neighborhood Hits	194
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

THOC3_MOUSE
θ value	2.44474e-05 (rank : 111)	NC score	0.580272 (rank : 53)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	221
SwissProt Accessions	Q8VE80, Q9CWI8	Gene names	Thoc3
Domain Architecture
Description	THO complex subunit 3 (Tho3).

ARHG7_HUMAN
θ value	3.19293e-05 (rank : 112)	NC score	0.376568 (rank : 253)
Query Neighborhood Hits	537	Target Neighborhood Hits	347	Shared Neighborhood Hits	197
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ASPP1_HUMAN
θ value	3.19293e-05 (rank : 113)	NC score	0.236763 (rank : 376)
Query Neighborhood Hits	537	Target Neighborhood Hits	956	Shared Neighborhood Hits	186
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MYO1F_MOUSE
θ value	3.19293e-05 (rank : 114)	NC score	0.182674 (rank : 421)
Query Neighborhood Hits	537	Target Neighborhood Hits	262	Shared Neighborhood Hits	181
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PPIP1_MOUSE
θ value	3.19293e-05 (rank : 115)	NC score	0.403789 (rank : 222)
Query Neighborhood Hits	537	Target Neighborhood Hits	377	Shared Neighborhood Hits	201
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PWP1_MOUSE
θ value	3.19293e-05 (rank : 116)	NC score	0.536535 (rank : 102)
Query Neighborhood Hits	537	Target Neighborhood Hits	278	Shared Neighborhood Hits	200
SwissProt Accessions	Q99LL5, Q9D6T6	Gene names	Pwp1
Domain Architecture	No domain graphic available
Description	Periodic tryptophan protein 1 homolog.

SH3G2_HUMAN
θ value	3.19293e-05 (rank : 117)	NC score	0.383869 (rank : 243)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	182
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SRC8_HUMAN
θ value	3.19293e-05 (rank : 118)	NC score	0.413160 (rank : 204)
Query Neighborhood Hits	537	Target Neighborhood Hits	269	Shared Neighborhood Hits	184
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	3.19293e-05 (rank : 119)	NC score	0.409900 (rank : 209)
Query Neighborhood Hits	537	Target Neighborhood Hits	292	Shared Neighborhood Hits	183
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC_MOUSE
θ value	3.19293e-05 (rank : 120)	NC score	0.398783 (rank : 231)
Query Neighborhood Hits	537	Target Neighborhood Hits	268	Shared Neighborhood Hits	178
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

WDR13_MOUSE
θ value	3.19293e-05 (rank : 121)	NC score	0.451442 (rank : 165)
Query Neighborhood Hits	537	Target Neighborhood Hits	195	Shared Neighborhood Hits	166
SwissProt Accessions	Q91V09	Gene names	Wdr13
Domain Architecture
Description	WD repeat protein 13.

ARHG6_MOUSE
θ value	4.1701e-05 (rank : 122)	NC score	0.367218 (rank : 272)
Query Neighborhood Hits	537	Target Neighborhood Hits	394	Shared Neighborhood Hits	196
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG9_HUMAN
θ value	4.1701e-05 (rank : 123)	NC score	0.281919 (rank : 345)
Query Neighborhood Hits	537	Target Neighborhood Hits	235	Shared Neighborhood Hits	156
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	4.1701e-05 (rank : 124)	NC score	0.282320 (rank : 342)
Query Neighborhood Hits	537	Target Neighborhood Hits	234	Shared Neighborhood Hits	157
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CORO6_MOUSE
θ value	4.1701e-05 (rank : 125)	NC score	0.434611 (rank : 191)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	179
SwissProt Accessions	Q920M5, Q920M3, Q920M4	Gene names	Coro6
Domain Architecture	No domain graphic available
Description	Coronin-6 (Clipin E).

IASPP_MOUSE
θ value	4.1701e-05 (rank : 126)	NC score	0.239837 (rank : 373)
Query Neighborhood Hits	537	Target Neighborhood Hits	1024	Shared Neighborhood Hits	174
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PPIP1_HUMAN
θ value	4.1701e-05 (rank : 127)	NC score	0.400758 (rank : 229)
Query Neighborhood Hits	537	Target Neighborhood Hits	389	Shared Neighborhood Hits	202
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

BTK_MOUSE
θ value	5.44631e-05 (rank : 128)	NC score	0.151517 (rank : 457)
Query Neighborhood Hits	537	Target Neighborhood Hits	1017	Shared Neighborhood Hits	179
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

MYO1F_HUMAN
θ value	5.44631e-05 (rank : 129)	NC score	0.182939 (rank : 420)
Query Neighborhood Hits	537	Target Neighborhood Hits	275	Shared Neighborhood Hits	183
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

WDR61_HUMAN
θ value	5.44631e-05 (rank : 130)	NC score	0.587161 (rank : 44)
Query Neighborhood Hits	537	Target Neighborhood Hits	334	Shared Neighborhood Hits	225
SwissProt Accessions	Q9GZS3, Q6IA22, Q7Z4X4	Gene names	WDR61
Domain Architecture	No domain graphic available
Description	WD repeat protein 61 (Meiotic recombination REC14 protein homolog).

WDR61_MOUSE
θ value	5.44631e-05 (rank : 131)	NC score	0.587303 (rank : 41)
Query Neighborhood Hits	537	Target Neighborhood Hits	331	Shared Neighborhood Hits	224
SwissProt Accessions	Q9ERF3, Q3U562, Q9CZP1	Gene names	Wdr61
Domain Architecture	No domain graphic available
Description	WD repeat protein 61 (Meiotic recombination REC14 protein homolog).

ARHG7_MOUSE
θ value	7.1131e-05 (rank : 132)	NC score	0.380272 (rank : 249)
Query Neighborhood Hits	537	Target Neighborhood Hits	396	Shared Neighborhood Hits	201
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

FBW1B_HUMAN
θ value	7.1131e-05 (rank : 133)	NC score	0.571489 (rank : 72)
Query Neighborhood Hits	537	Target Neighborhood Hits	327	Shared Neighborhood Hits	221
SwissProt Accessions	Q9UKB1, Q9P2S8, Q9P2S9, Q9Y4C6	Gene names	FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Domain Architecture
Description	F-box/WD repeat protein 11 (F-box/WD repeat protein 1B) (F-box and WD repeats protein beta-TrCP2).

GRAP_MOUSE
θ value	7.1131e-05 (rank : 134)	NC score	0.430726 (rank : 192)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	200
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

MYO1E_HUMAN
θ value	7.1131e-05 (rank : 135)	NC score	0.175217 (rank : 430)
Query Neighborhood Hits	537	Target Neighborhood Hits	293	Shared Neighborhood Hits	177
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NCK1_HUMAN
θ value	7.1131e-05 (rank : 136)	NC score	0.429367 (rank : 194)
Query Neighborhood Hits	537	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

VAV_HUMAN
θ value	7.1131e-05 (rank : 137)	NC score	0.344045 (rank : 301)
Query Neighborhood Hits	537	Target Neighborhood Hits	452	Shared Neighborhood Hits	194
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

WDR1_HUMAN
θ value	7.1131e-05 (rank : 138)	NC score	0.550175 (rank : 96)
Query Neighborhood Hits	537	Target Neighborhood Hits	292	Shared Neighborhood Hits	211
SwissProt Accessions	O75083, O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0	Gene names	WDR1
Domain Architecture
Description	WD repeat protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1).

AAMP_HUMAN
θ value	9.29e-05 (rank : 139)	NC score	0.575667 (rank : 63)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	215
SwissProt Accessions	Q13685, Q8WUJ9, Q96H92	Gene names	AAMP
Domain Architecture
Description	Angio-associated migratory cell protein.

GRB2_HUMAN
θ value	9.29e-05 (rank : 140)	NC score	0.438034 (rank : 183)
Query Neighborhood Hits	537	Target Neighborhood Hits	310	Shared Neighborhood Hits	196
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

IASPP_HUMAN
θ value	9.29e-05 (rank : 141)	NC score	0.260335 (rank : 351)
Query Neighborhood Hits	537	Target Neighborhood Hits	688	Shared Neighborhood Hits	161
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PLAP_MOUSE
θ value	9.29e-05 (rank : 142)	NC score	0.538267 (rank : 101)
Query Neighborhood Hits	537	Target Neighborhood Hits	261	Shared Neighborhood Hits	203
SwissProt Accessions	P27612, Q8C6C4	Gene names	Plaa, Plap
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP).

SH3K1_MOUSE
θ value	9.29e-05 (rank : 143)	NC score	0.435306 (rank : 190)
Query Neighborhood Hits	537	Target Neighborhood Hits	332	Shared Neighborhood Hits	197
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

FAN_MOUSE
θ value	0.000121331 (rank : 144)	NC score	0.454716 (rank : 163)
Query Neighborhood Hits	537	Target Neighborhood Hits	292	Shared Neighborhood Hits	206
SwissProt Accessions	O35242	Gene names	Nsmaf, Fan
Domain Architecture
Description	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation).

FBW1A_HUMAN
θ value	0.000121331 (rank : 145)	NC score	0.569412 (rank : 75)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	220
SwissProt Accessions	Q9Y297, Q9Y213	Gene names	BTRC, BTRCP, FBW1A, FBXW1A
Domain Architecture
Description	F-box/WD repeat protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit).

GBB5_HUMAN
θ value	0.000121331 (rank : 146)	NC score	0.572663 (rank : 68)
Query Neighborhood Hits	537	Target Neighborhood Hits	299	Shared Neighborhood Hits	225
SwissProt Accessions	O14775, Q9HAU9	Gene names	GNB5
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 5 (Transducin beta chain 5) (Gbeta5).

GRB2_MOUSE
θ value	0.000121331 (rank : 147)	NC score	0.437626 (rank : 184)
Query Neighborhood Hits	537	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

M3K9_HUMAN
θ value	0.000121331 (rank : 148)	NC score	0.134603 (rank : 478)
Query Neighborhood Hits	537	Target Neighborhood Hits	1123	Shared Neighborhood Hits	188
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

NCK2_HUMAN
θ value	0.000121331 (rank : 149)	NC score	0.427842 (rank : 197)
Query Neighborhood Hits	537	Target Neighborhood Hits	310	Shared Neighborhood Hits	196
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NPHP1_HUMAN
θ value	0.000121331 (rank : 150)	NC score	0.345856 (rank : 298)
Query Neighborhood Hits	537	Target Neighborhood Hits	288	Shared Neighborhood Hits	168
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PLAP_HUMAN
θ value	0.000121331 (rank : 151)	NC score	0.535763 (rank : 103)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	202
SwissProt Accessions	Q9Y263, Q53EU5, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1	Gene names	PLAA, PLAP
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP) (PLA2P).

TEC_HUMAN
θ value	0.000121331 (rank : 152)	NC score	0.133397 (rank : 479)
Query Neighborhood Hits	537	Target Neighborhood Hits	1006	Shared Neighborhood Hits	153
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	0.000121331 (rank : 153)	NC score	0.131590 (rank : 484)
Query Neighborhood Hits	537	Target Neighborhood Hits	1006	Shared Neighborhood Hits	154
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

UTP15_HUMAN
θ value	0.000121331 (rank : 154)	NC score	0.555238 (rank : 88)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	214
SwissProt Accessions	Q8TED0, Q6IA60, Q96E08, Q9H9F8	Gene names	UTP15
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 15 homolog.

WDR1_MOUSE
θ value	0.000121331 (rank : 155)	NC score	0.552676 (rank : 92)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	212
SwissProt Accessions	O88342	Gene names	Wdr1
Domain Architecture
Description	WD repeat protein 1 (Actin-interacting protein 1) (AIP1).

ANM2_MOUSE
θ value	0.000158464 (rank : 156)	NC score	0.254227 (rank : 358)
Query Neighborhood Hits	537	Target Neighborhood Hits	175	Shared Neighborhood Hits	143
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APAF_HUMAN
θ value	0.000158464 (rank : 157)	NC score	0.572568 (rank : 69)
Query Neighborhood Hits	537	Target Neighborhood Hits	334	Shared Neighborhood Hits	226
SwissProt Accessions	O14727, O43297, Q7Z438, Q9BXZ6, Q9UBZ5, Q9UGN8, Q9UGN9, Q9UGP0, Q9UJ58, Q9UJ59, Q9UJ60, Q9UJ61, Q9UJ62, Q9UJ63, Q9UJ64, Q9UJ65, Q9UJ66, Q9UJ67, Q9UNC9	Gene names	APAF1, KIAA0413
Domain Architecture
Description	Apoptotic protease-activating factor 1 (Apaf-1).

CD2AP_HUMAN
θ value	0.000158464 (rank : 158)	NC score	0.441466 (rank : 177)
Query Neighborhood Hits	537	Target Neighborhood Hits	315	Shared Neighborhood Hits	197
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

FGR_HUMAN
θ value	0.000158464 (rank : 159)	NC score	0.170010 (rank : 437)
Query Neighborhood Hits	537	Target Neighborhood Hits	1067	Shared Neighborhood Hits	187
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GBB5_MOUSE
θ value	0.000158464 (rank : 160)	NC score	0.572405 (rank : 70)
Query Neighborhood Hits	537	Target Neighborhood Hits	298	Shared Neighborhood Hits	225
SwissProt Accessions	P62881, O35354, P54314, Q91WB3	Gene names	Gnb5
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 5 (Transducin beta chain 5) (Gbeta5).

GRAP2_MOUSE
θ value	0.000158464 (rank : 161)	NC score	0.436947 (rank : 187)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	194
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

HCK_HUMAN
θ value	0.000158464 (rank : 162)	NC score	0.154997 (rank : 454)
Query Neighborhood Hits	537	Target Neighborhood Hits	1035	Shared Neighborhood Hits	187
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

PWP2_HUMAN
θ value	0.000158464 (rank : 163)	NC score	0.558274 (rank : 84)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	220
SwissProt Accessions	Q15269, Q96A77	Gene names	PWP2H, PWP2
Domain Architecture
Description	Periodic tryptophan protein 2 homolog.

COR1C_HUMAN
θ value	0.00020696 (rank : 164)	NC score	0.409337 (rank : 210)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	176
SwissProt Accessions	Q9ULV4, Q9NSK5	Gene names	CORO1C, CRNN4
Domain Architecture
Description	Coronin-1C (Coronin-3) (hCRNN4).

CRK_HUMAN
θ value	0.00020696 (rank : 165)	NC score	0.367012 (rank : 273)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	191
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.00020696 (rank : 166)	NC score	0.369160 (rank : 269)
Query Neighborhood Hits	537	Target Neighborhood Hits	314	Shared Neighborhood Hits	189
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DDEF2_HUMAN
θ value	0.00020696 (rank : 167)	NC score	0.181434 (rank : 423)
Query Neighborhood Hits	537	Target Neighborhood Hits	599	Shared Neighborhood Hits	157
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

HCLS1_MOUSE
θ value	0.00020696 (rank : 168)	NC score	0.409007 (rank : 213)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	172
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PACN3_MOUSE
θ value	0.00020696 (rank : 169)	NC score	0.351782 (rank : 293)
Query Neighborhood Hits	537	Target Neighborhood Hits	380	Shared Neighborhood Hits	179
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

WDR71_HUMAN
θ value	0.00020696 (rank : 170)	NC score	0.588548 (rank : 36)
Query Neighborhood Hits	537	Target Neighborhood Hits	241	Shared Neighborhood Hits	195
SwissProt Accessions	Q9BRP4, Q4G165, Q53HS9, Q7Z500, Q8TBU6, Q9HAB6	Gene names	WDR71
Domain Architecture	No domain graphic available
Description	WD repeat protein 71 (Protein G-16).

ARHG4_HUMAN
θ value	0.000270298 (rank : 171)	NC score	0.292220 (rank : 336)
Query Neighborhood Hits	537	Target Neighborhood Hits	242	Shared Neighborhood Hits	164
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

COR1C_MOUSE
θ value	0.000270298 (rank : 172)	NC score	0.409183 (rank : 211)
Query Neighborhood Hits	537	Target Neighborhood Hits	251	Shared Neighborhood Hits	177
SwissProt Accessions	Q9WUM4, Q8VCQ5	Gene names	Coro1c
Domain Architecture
Description	Coronin-1C (Coronin-3).

HCK_MOUSE
θ value	0.000270298 (rank : 173)	NC score	0.155230 (rank : 453)
Query Neighborhood Hits	537	Target Neighborhood Hits	1029	Shared Neighborhood Hits	185
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

PRP19_MOUSE
θ value	0.000270298 (rank : 174)	NC score	0.575278 (rank : 66)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	223
SwissProt Accessions	Q99KP6, Q3TP64, Q8BKZ5, Q8BVQ4	Gene names	Prpf19, Prp19, Snev
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor 19 (PRP19/PSO4 homolog) (Nuclear matrix protein 200) (Nuclear matrix protein SNEV).

RUFY2_HUMAN
θ value	0.000270298 (rank : 175)	NC score	0.030294 (rank : 867)
Query Neighborhood Hits	537	Target Neighborhood Hits	1208	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

SH3G1_HUMAN
θ value	0.000270298 (rank : 176)	NC score	0.369723 (rank : 266)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	182
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

WDR12_HUMAN
θ value	0.000270298 (rank : 177)	NC score	0.556673 (rank : 86)
Query Neighborhood Hits	537	Target Neighborhood Hits	300	Shared Neighborhood Hits	212
SwissProt Accessions	Q9GZL7, Q96HU0, Q9NV80, Q9NYI8	Gene names	WDR12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

BCAR1_HUMAN
θ value	0.00035302 (rank : 178)	NC score	0.289683 (rank : 338)
Query Neighborhood Hits	537	Target Neighborhood Hits	554	Shared Neighborhood Hits	169
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CAF1B_HUMAN
θ value	0.00035302 (rank : 179)	NC score	0.552897 (rank : 91)
Query Neighborhood Hits	537	Target Neighborhood Hits	345	Shared Neighborhood Hits	215
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

COR1B_HUMAN
θ value	0.00035302 (rank : 180)	NC score	0.391573 (rank : 238)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	171
SwissProt Accessions	Q9BR76	Gene names	CORO1B
Domain Architecture
Description	Coronin-1B (Coronin-2).

ES8L1_MOUSE
θ value	0.00035302 (rank : 181)	NC score	0.229017 (rank : 383)
Query Neighborhood Hits	537	Target Neighborhood Hits	143	Shared Neighborhood Hits	97
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

LIS1_HUMAN
θ value	0.00035302 (rank : 182)	NC score	0.587303 (rank : 42)
Query Neighborhood Hits	537	Target Neighborhood Hits	333	Shared Neighborhood Hits	222
SwissProt Accessions	P43034, Q8WZ88, Q8WZ89	Gene names	PAFAH1B1, LIS1, MDCR, PAFAHA
Domain Architecture
Description	Platelet-activating factor acetylhydrolase IB subunit alpha (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) (Lissencephaly-1 protein) (LIS-1).

LIS1_MOUSE
θ value	0.00035302 (rank : 183)	NC score	0.587257 (rank : 43)
Query Neighborhood Hits	537	Target Neighborhood Hits	336	Shared Neighborhood Hits	222
SwissProt Accessions	P63005, O35592, P43035, P81692, Q9R2A6	Gene names	Pafah1b1, Lis-1, Lis1, Pafaha
Domain Architecture	No domain graphic available
Description	Platelet-activating factor acetylhydrolase IB subunit alpha (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) (Lissencephaly-1 protein) (LIS-1).

PACN2_MOUSE
θ value	0.00035302 (rank : 184)	NC score	0.373673 (rank : 257)
Query Neighborhood Hits	537	Target Neighborhood Hits	382	Shared Neighborhood Hits	196
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PWP1_HUMAN
θ value	0.00035302 (rank : 185)	NC score	0.515880 (rank : 110)
Query Neighborhood Hits	537	Target Neighborhood Hits	261	Shared Neighborhood Hits	193
SwissProt Accessions	Q13610	Gene names	PWP1
Domain Architecture
Description	Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502).

SPTA2_HUMAN
θ value	0.00035302 (rank : 186)	NC score	0.188841 (rank : 417)
Query Neighborhood Hits	537	Target Neighborhood Hits	888	Shared Neighborhood Hits	201
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

VAV_MOUSE
θ value	0.00035302 (rank : 187)	NC score	0.340643 (rank : 302)
Query Neighborhood Hits	537	Target Neighborhood Hits	430	Shared Neighborhood Hits	196
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

WDR23_HUMAN
θ value	0.00035302 (rank : 188)	NC score	0.522895 (rank : 109)
Query Neighborhood Hits	537	Target Neighborhood Hits	267	Shared Neighborhood Hits	205
SwissProt Accessions	Q8TEB1, Q86U00, Q86U39, Q8NDN2, Q9H2J0, Q9H3A3, Q9H5C9	Gene names	WDR23
Domain Architecture
Description	WD repeat protein 23.

WDR23_MOUSE
θ value	0.00035302 (rank : 189)	NC score	0.524835 (rank : 108)
Query Neighborhood Hits	537	Target Neighborhood Hits	271	Shared Neighborhood Hits	204
SwissProt Accessions	Q91VU6, Q3U836, Q8JZV8	Gene names	Wdr23, D14Ucla1
Domain Architecture
Description	WD repeat protein 23.

BLK_MOUSE
θ value	0.000461057 (rank : 190)	NC score	0.142324 (rank : 467)
Query Neighborhood Hits	537	Target Neighborhood Hits	992	Shared Neighborhood Hits	146
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

COR1B_MOUSE
θ value	0.000461057 (rank : 191)	NC score	0.390663 (rank : 240)
Query Neighborhood Hits	537	Target Neighborhood Hits	235	Shared Neighborhood Hits	165
SwissProt Accessions	Q9WUM3, Q3UEB1, Q9CVA2	Gene names	Coro1b
Domain Architecture
Description	Coronin-1B (Coronin-2).

NCF4_HUMAN
θ value	0.000461057 (rank : 192)	NC score	0.357408 (rank : 285)
Query Neighborhood Hits	537	Target Neighborhood Hits	161	Shared Neighborhood Hits	130
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN3_HUMAN
θ value	0.000461057 (rank : 193)	NC score	0.348950 (rank : 296)
Query Neighborhood Hits	537	Target Neighborhood Hits	385	Shared Neighborhood Hits	176
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

RAE1L_MOUSE
θ value	0.000461057 (rank : 194)	NC score	0.484371 (rank : 140)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	179
SwissProt Accessions	Q8C570, Q3UKD4	Gene names	Rae1, Mrnp41
Domain Architecture	No domain graphic available
Description	mRNA-associated protein mrnp 41 (Rae1 protein homolog).

STAM2_MOUSE
θ value	0.000461057 (rank : 195)	NC score	0.397056 (rank : 233)
Query Neighborhood Hits	537	Target Neighborhood Hits	285	Shared Neighborhood Hits	190
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

WDR26_HUMAN
θ value	0.000461057 (rank : 196)	NC score	0.564647 (rank : 80)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	220
SwissProt Accessions	Q9H7D7, Q86UY4	Gene names	WDR26
Domain Architecture
Description	WD repeat protein 26.

ANM2_HUMAN
θ value	0.000602161 (rank : 197)	NC score	0.260455 (rank : 350)
Query Neighborhood Hits	537	Target Neighborhood Hits	175	Shared Neighborhood Hits	148
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

COR1A_MOUSE
θ value	0.000602161 (rank : 198)	NC score	0.411266 (rank : 207)
Query Neighborhood Hits	537	Target Neighborhood Hits	243	Shared Neighborhood Hits	180
SwissProt Accessions	O89053, Q7TMU0, Q9R1Y8, Q9R288	Gene names	Coro1a, Coro1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

CORO7_HUMAN
θ value	0.000602161 (rank : 199)	NC score	0.473126 (rank : 146)
Query Neighborhood Hits	537	Target Neighborhood Hits	315	Shared Neighborhood Hits	209
SwissProt Accessions	P57737	Gene names	CORO7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

HCLS1_HUMAN
θ value	0.000602161 (rank : 200)	NC score	0.406967 (rank : 216)
Query Neighborhood Hits	537	Target Neighborhood Hits	358	Shared Neighborhood Hits	175
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NCF4_MOUSE
θ value	0.000602161 (rank : 201)	NC score	0.373680 (rank : 256)
Query Neighborhood Hits	537	Target Neighborhood Hits	177	Shared Neighborhood Hits	142
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN2_HUMAN
θ value	0.000602161 (rank : 202)	NC score	0.373023 (rank : 258)
Query Neighborhood Hits	537	Target Neighborhood Hits	339	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PLRG1_HUMAN
θ value	0.000602161 (rank : 203)	NC score	0.571190 (rank : 73)
Query Neighborhood Hits	537	Target Neighborhood Hits	318	Shared Neighborhood Hits	221
SwissProt Accessions	O43660, Q8WUD8	Gene names	PLRG1
Domain Architecture
Description	Pleiotropic regulator 1.

PRP19_HUMAN
θ value	0.000602161 (rank : 204)	NC score	0.574350 (rank : 67)
Query Neighborhood Hits	537	Target Neighborhood Hits	333	Shared Neighborhood Hits	223
SwissProt Accessions	Q9UMS4	Gene names	PRPF19, NMP200, PRP19
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor 19 (PRP19/PSO4 homolog) (Nuclear matrix protein 200) (hPso4).

SH3G3_MOUSE
θ value	0.000602161 (rank : 205)	NC score	0.383069 (rank : 244)
Query Neighborhood Hits	537	Target Neighborhood Hits	236	Shared Neighborhood Hits	180
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

STAC3_HUMAN
θ value	0.000602161 (rank : 206)	NC score	0.368554 (rank : 271)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	153
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.000602161 (rank : 207)	NC score	0.369496 (rank : 267)
Query Neighborhood Hits	537	Target Neighborhood Hits	232	Shared Neighborhood Hits	154
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VINEX_HUMAN
θ value	0.000602161 (rank : 208)	NC score	0.408768 (rank : 214)
Query Neighborhood Hits	537	Target Neighborhood Hits	270	Shared Neighborhood Hits	191
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

WDR26_MOUSE
θ value	0.000602161 (rank : 209)	NC score	0.563256 (rank : 82)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	220
SwissProt Accessions	Q8C6G8, Q8C4F3, Q8VDZ6	Gene names	Wdr26
Domain Architecture
Description	WD repeat protein 26.

CORO7_MOUSE
θ value	0.000786445 (rank : 210)	NC score	0.481743 (rank : 141)
Query Neighborhood Hits	537	Target Neighborhood Hits	312	Shared Neighborhood Hits	217
SwissProt Accessions	Q9D2V7, Q3UDJ4, Q6P8Y8, Q8C9V7	Gene names	Coro7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

NPHP1_MOUSE
θ value	0.000786445 (rank : 211)	NC score	0.371236 (rank : 260)
Query Neighborhood Hits	537	Target Neighborhood Hits	267	Shared Neighborhood Hits	176
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PACN1_HUMAN
θ value	0.000786445 (rank : 212)	NC score	0.365457 (rank : 275)
Query Neighborhood Hits	537	Target Neighborhood Hits	320	Shared Neighborhood Hits	185
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.000786445 (rank : 213)	NC score	0.366475 (rank : 274)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	184
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RIMB2_MOUSE
θ value	0.000786445 (rank : 214)	NC score	0.239686 (rank : 374)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	107
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SPTA1_HUMAN
θ value	0.000786445 (rank : 215)	NC score	0.173060 (rank : 431)
Query Neighborhood Hits	537	Target Neighborhood Hits	748	Shared Neighborhood Hits	194
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

BCAR1_MOUSE
θ value	0.00102713 (rank : 216)	NC score	0.299402 (rank : 334)
Query Neighborhood Hits	537	Target Neighborhood Hits	438	Shared Neighborhood Hits	168
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DDEF2_MOUSE
θ value	0.00102713 (rank : 217)	NC score	0.180317 (rank : 425)
Query Neighborhood Hits	537	Target Neighborhood Hits	625	Shared Neighborhood Hits	157
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EFS_HUMAN
θ value	0.00102713 (rank : 218)	NC score	0.292308 (rank : 335)
Query Neighborhood Hits	537	Target Neighborhood Hits	348	Shared Neighborhood Hits	152
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	0.00102713 (rank : 219)	NC score	0.300231 (rank : 333)
Query Neighborhood Hits	537	Target Neighborhood Hits	389	Shared Neighborhood Hits	156
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FRK_HUMAN
θ value	0.00102713 (rank : 220)	NC score	0.141595 (rank : 469)
Query Neighborhood Hits	537	Target Neighborhood Hits	1058	Shared Neighborhood Hits	188
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

OSTF1_HUMAN
θ value	0.00102713 (rank : 221)	NC score	0.327394 (rank : 311)
Query Neighborhood Hits	537	Target Neighborhood Hits	466	Shared Neighborhood Hits	190
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PLRG1_MOUSE
θ value	0.00102713 (rank : 222)	NC score	0.569417 (rank : 74)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	220
SwissProt Accessions	Q922V4, O55039	Gene names	Plrg1
Domain Architecture
Description	Pleiotropic regulator 1.

PWP2_MOUSE
θ value	0.00102713 (rank : 223)	NC score	0.553295 (rank : 90)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	218
SwissProt Accessions	Q8BU03, Q8BTR0	Gene names	Pwp2h
Domain Architecture
Description	Periodic tryptophan protein 2 homolog.

SRC_MOUSE
θ value	0.00102713 (rank : 224)	NC score	0.150440 (rank : 458)
Query Neighborhood Hits	537	Target Neighborhood Hits	1033	Shared Neighborhood Hits	173
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

VAV2_HUMAN
θ value	0.00102713 (rank : 225)	NC score	0.319448 (rank : 317)
Query Neighborhood Hits	537	Target Neighborhood Hits	453	Shared Neighborhood Hits	191
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VINEX_MOUSE
θ value	0.00102713 (rank : 226)	NC score	0.409147 (rank : 212)
Query Neighborhood Hits	537	Target Neighborhood Hits	286	Shared Neighborhood Hits	195
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WDR12_MOUSE
θ value	0.00102713 (rank : 227)	NC score	0.552434 (rank : 93)
Query Neighborhood Hits	537	Target Neighborhood Hits	301	Shared Neighborhood Hits	214
SwissProt Accessions	Q9JJA4, Q9CST3, Q9JKF5	Gene names	Wdr12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

CAF1B_MOUSE
θ value	0.00134147 (rank : 228)	NC score	0.550368 (rank : 95)
Query Neighborhood Hits	537	Target Neighborhood Hits	385	Shared Neighborhood Hits	223
SwissProt Accessions	Q9D0N7	Gene names	Chaf1b
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60).

PTK6_HUMAN
θ value	0.00134147 (rank : 229)	NC score	0.128294 (rank : 492)
Query Neighborhood Hits	537	Target Neighborhood Hits	1020	Shared Neighborhood Hits	167
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

RHG04_HUMAN
θ value	0.00134147 (rank : 230)	NC score	0.235133 (rank : 378)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	164
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ASPP2_HUMAN
θ value	0.00175202 (rank : 231)	NC score	0.193449 (rank : 413)
Query Neighborhood Hits	537	Target Neighborhood Hits	1156	Shared Neighborhood Hits	173
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ES8L2_MOUSE
θ value	0.00175202 (rank : 232)	NC score	0.243423 (rank : 369)
Query Neighborhood Hits	537	Target Neighborhood Hits	169	Shared Neighborhood Hits	127
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FAN_HUMAN
θ value	0.00175202 (rank : 233)	NC score	0.459683 (rank : 160)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	214
SwissProt Accessions	Q92636	Gene names	NSMAF, FAN
Domain Architecture
Description	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation).

OSTF1_MOUSE
θ value	0.00175202 (rank : 234)	NC score	0.318185 (rank : 319)
Query Neighborhood Hits	537	Target Neighborhood Hits	467	Shared Neighborhood Hits	190
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PK1IP_HUMAN
θ value	0.00175202 (rank : 235)	NC score	0.508234 (rank : 114)
Query Neighborhood Hits	537	Target Neighborhood Hits	277	Shared Neighborhood Hits	196
SwissProt Accessions	Q9NWT1, Q5T4J2, Q96QJ8, Q96T87	Gene names	PAK1IP1, PIP1, WDR84
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (PAK/PLC-interacting protein 1) (hPIP1) (WD repeat protein 84).

PTK6_MOUSE
θ value	0.00175202 (rank : 236)	NC score	0.131023 (rank : 486)
Query Neighborhood Hits	537	Target Neighborhood Hits	1026	Shared Neighborhood Hits	168
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RAE1L_HUMAN
θ value	0.00175202 (rank : 237)	NC score	0.480192 (rank : 142)
Query Neighborhood Hits	537	Target Neighborhood Hits	222	Shared Neighborhood Hits	178
SwissProt Accessions	P78406, O15306, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6	Gene names	RAE1, MRNP41
Domain Architecture
Description	mRNA-associated protein mrnp 41 (Rae1 protein homolog).

RIMB2_HUMAN
θ value	0.00175202 (rank : 238)	NC score	0.241943 (rank : 372)
Query Neighborhood Hits	537	Target Neighborhood Hits	263	Shared Neighborhood Hits	113
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SPTA1_MOUSE
θ value	0.00175202 (rank : 239)	NC score	0.178806 (rank : 429)
Query Neighborhood Hits	537	Target Neighborhood Hits	675	Shared Neighborhood Hits	189
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

STAM2_HUMAN
θ value	0.00175202 (rank : 240)	NC score	0.382700 (rank : 246)
Query Neighborhood Hits	537	Target Neighborhood Hits	288	Shared Neighborhood Hits	188
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

WDR48_HUMAN
θ value	0.00175202 (rank : 241)	NC score	0.555661 (rank : 87)
Query Neighborhood Hits	537	Target Neighborhood Hits	291	Shared Neighborhood Hits	214
SwissProt Accessions	Q8TAF3, Q63HJ2, Q658Y1, Q8N3Z1, Q9NSK8, Q9P279	Gene names	WDR48, KIAA1449
Domain Architecture	No domain graphic available
Description	WD repeat protein 48 (WD repeat endosomal protein) (p80).

CSKI1_MOUSE
θ value	0.00228821 (rank : 242)	NC score	0.039765 (rank : 856)
Query Neighborhood Hits	537	Target Neighborhood Hits	1031	Shared Neighborhood Hits	69
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ES8L2_HUMAN
θ value	0.00228821 (rank : 243)	NC score	0.247402 (rank : 365)
Query Neighborhood Hits	537	Target Neighborhood Hits	193	Shared Neighborhood Hits	129
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

VAV2_MOUSE
θ value	0.00228821 (rank : 244)	NC score	0.317400 (rank : 320)
Query Neighborhood Hits	537	Target Neighborhood Hits	456	Shared Neighborhood Hits	190
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	0.00228821 (rank : 245)	NC score	0.310947 (rank : 324)
Query Neighborhood Hits	537	Target Neighborhood Hits	398	Shared Neighborhood Hits	187
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

WDR48_MOUSE
θ value	0.00228821 (rank : 246)	NC score	0.554992 (rank : 89)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	214
SwissProt Accessions	Q8BH57, Q80TD4, Q80XI0, Q8BRM0, Q8CBK0, Q922Z9, Q9CRR1, Q9CSL0	Gene names	Wdr48, Kiaa1449
Domain Architecture	No domain graphic available
Description	WD repeat protein 48.

CT032_HUMAN
θ value	0.00298849 (rank : 247)	NC score	0.310153 (rank : 326)
Query Neighborhood Hits	537	Target Neighborhood Hits	235	Shared Neighborhood Hits	150
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

LYN_MOUSE
θ value	0.00298849 (rank : 248)	NC score	0.143424 (rank : 463)
Query Neighborhood Hits	537	Target Neighborhood Hits	1023	Shared Neighborhood Hits	168
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NCF2_HUMAN
θ value	0.00298849 (rank : 249)	NC score	0.425958 (rank : 200)
Query Neighborhood Hits	537	Target Neighborhood Hits	229	Shared Neighborhood Hits	174
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NGEF_HUMAN
θ value	0.00298849 (rank : 250)	NC score	0.170104 (rank : 435)
Query Neighborhood Hits	537	Target Neighborhood Hits	166	Shared Neighborhood Hits	81
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SH3G1_MOUSE
θ value	0.00298849 (rank : 251)	NC score	0.364850 (rank : 276)
Query Neighborhood Hits	537	Target Neighborhood Hits	291	Shared Neighborhood Hits	179
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

TBL2_HUMAN
θ value	0.00298849 (rank : 252)	NC score	0.496136 (rank : 135)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	182
SwissProt Accessions	Q9Y4P3, Q9UQE2	Gene names	TBL2, WBSCR13
Domain Architecture
Description	Transducin beta-like 2 protein (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosome region 13 protein).

WSB1_HUMAN
θ value	0.00298849 (rank : 253)	NC score	0.572197 (rank : 71)
Query Neighborhood Hits	537	Target Neighborhood Hits	337	Shared Neighborhood Hits	221
SwissProt Accessions	Q9Y6I7, Q9NRB1, Q9UBH9, Q9UNN6	Gene names	WSB1, SWIP1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box- containing WD protein SWiP-1).

DDEF1_MOUSE
θ value	0.00390308 (rank : 254)	NC score	0.189219 (rank : 415)
Query Neighborhood Hits	537	Target Neighborhood Hits	592	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ES8L1_HUMAN
θ value	0.00390308 (rank : 255)	NC score	0.230988 (rank : 382)
Query Neighborhood Hits	537	Target Neighborhood Hits	162	Shared Neighborhood Hits	107
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

NGEF_MOUSE
θ value	0.00390308 (rank : 256)	NC score	0.170147 (rank : 434)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

VAV3_MOUSE
θ value	0.00390308 (rank : 257)	NC score	0.306008 (rank : 329)
Query Neighborhood Hits	537	Target Neighborhood Hits	404	Shared Neighborhood Hits	187
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

WDR22_HUMAN
θ value	0.00390308 (rank : 258)	NC score	0.463480 (rank : 156)
Query Neighborhood Hits	537	Target Neighborhood Hits	328	Shared Neighborhood Hits	193
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

WDR22_MOUSE
θ value	0.00390308 (rank : 259)	NC score	0.466007 (rank : 153)
Query Neighborhood Hits	537	Target Neighborhood Hits	302	Shared Neighborhood Hits	191
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

WDR65_HUMAN
θ value	0.00390308 (rank : 260)	NC score	0.487482 (rank : 139)
Query Neighborhood Hits	537	Target Neighborhood Hits	238	Shared Neighborhood Hits	188
SwissProt Accessions	Q96MR6, Q5TAI0	Gene names	WDR65
Domain Architecture	No domain graphic available
Description	WD repeat protein 65.

WDR79_HUMAN
θ value	0.00390308 (rank : 261)	NC score	0.436614 (rank : 188)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q9BUR4, Q9NW09	Gene names	WDR79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

LCK_HUMAN
θ value	0.00509761 (rank : 262)	NC score	0.132404 (rank : 481)
Query Neighborhood Hits	537	Target Neighborhood Hits	987	Shared Neighborhood Hits	130
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	0.00509761 (rank : 263)	NC score	0.131347 (rank : 485)
Query Neighborhood Hits	537	Target Neighborhood Hits	981	Shared Neighborhood Hits	130
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SH3G3_HUMAN
θ value	0.00509761 (rank : 264)	NC score	0.371942 (rank : 259)
Query Neighborhood Hits	537	Target Neighborhood Hits	222	Shared Neighborhood Hits	174
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

STRN_HUMAN
θ value	0.00509761 (rank : 265)	NC score	0.458357 (rank : 161)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	211
SwissProt Accessions	O43815, Q9NP38	Gene names	STRN
Domain Architecture
Description	Striatin.

NEBL_HUMAN
θ value	0.00665767 (rank : 266)	NC score	0.290039 (rank : 337)
Query Neighborhood Hits	537	Target Neighborhood Hits	457	Shared Neighborhood Hits	171
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	0.00665767 (rank : 267)	NC score	0.260280 (rank : 352)
Query Neighborhood Hits	537	Target Neighborhood Hits	420	Shared Neighborhood Hits	174
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

RUSC1_HUMAN
θ value	0.00665767 (rank : 268)	NC score	0.244672 (rank : 368)
Query Neighborhood Hits	537	Target Neighborhood Hits	226	Shared Neighborhood Hits	134
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

STTP1_MOUSE
θ value	0.00665767 (rank : 269)	NC score	0.427454 (rank : 199)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	205
SwissProt Accessions	Q91WG4, Q3TIH5, Q3TIT0, Q8CBW6, Q9ESY7	Gene names	Statip1
Domain Architecture	No domain graphic available
Description	Stat3-interacting protein (StIP1).

WDTC1_HUMAN
θ value	0.00665767 (rank : 270)	NC score	0.413400 (rank : 203)
Query Neighborhood Hits	537	Target Neighborhood Hits	299	Shared Neighborhood Hits	204
SwissProt Accessions	Q8N5D0, Q9NV87, Q9UPW4	Gene names	WDTC1, KIAA1037
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

WDTC1_MOUSE
θ value	0.00665767 (rank : 271)	NC score	0.412147 (rank : 205)
Query Neighborhood Hits	537	Target Neighborhood Hits	298	Shared Neighborhood Hits	204
SwissProt Accessions	Q80ZK9	Gene names	Wdtc1
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

ITK_HUMAN
θ value	0.00869519 (rank : 272)	NC score	0.124977 (rank : 496)
Query Neighborhood Hits	537	Target Neighborhood Hits	1016	Shared Neighborhood Hits	147
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

LYN_HUMAN
θ value	0.00869519 (rank : 273)	NC score	0.143412 (rank : 464)
Query Neighborhood Hits	537	Target Neighborhood Hits	1022	Shared Neighborhood Hits	167
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NCF1_MOUSE
θ value	0.00869519 (rank : 274)	NC score	0.374229 (rank : 255)
Query Neighborhood Hits	537	Target Neighborhood Hits	198	Shared Neighborhood Hits	164
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PEX7_MOUSE
θ value	0.00869519 (rank : 275)	NC score	0.551313 (rank : 94)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	212
SwissProt Accessions	P97865	Gene names	Pex7
Domain Architecture
Description	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7).

SRBS1_MOUSE
θ value	0.00869519 (rank : 276)	NC score	0.383010 (rank : 245)
Query Neighborhood Hits	537	Target Neighborhood Hits	409	Shared Neighborhood Hits	202
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ARHG4_MOUSE
θ value	0.0113563 (rank : 277)	NC score	0.232484 (rank : 381)
Query Neighborhood Hits	537	Target Neighborhood Hits	185	Shared Neighborhood Hits	118
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FNBP2_HUMAN
θ value	0.0113563 (rank : 278)	NC score	0.196775 (rank : 409)
Query Neighborhood Hits	537	Target Neighborhood Hits	432	Shared Neighborhood Hits	154
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

LASP1_HUMAN
θ value	0.0113563 (rank : 279)	NC score	0.318648 (rank : 318)
Query Neighborhood Hits	537	Target Neighborhood Hits	293	Shared Neighborhood Hits	153
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.0113563 (rank : 280)	NC score	0.316959 (rank : 321)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	153
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SRBS1_HUMAN
θ value	0.0113563 (rank : 281)	NC score	0.382511 (rank : 247)
Query Neighborhood Hits	537	Target Neighborhood Hits	396	Shared Neighborhood Hits	197
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

WDR37_MOUSE
θ value	0.0113563 (rank : 282)	NC score	0.559877 (rank : 83)
Query Neighborhood Hits	537	Target Neighborhood Hits	298	Shared Neighborhood Hits	211
SwissProt Accessions	Q8CBE3, Q80Y96, Q8CCL2	Gene names	Wdr37, Kiaa0982
Domain Architecture
Description	WD repeat protein 37.

ABI3_HUMAN
θ value	0.0148317 (rank : 283)	NC score	0.349047 (rank : 295)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	0.0148317 (rank : 284)	NC score	0.353714 (rank : 291)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	146
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CRKL_HUMAN
θ value	0.0148317 (rank : 285)	NC score	0.378196 (rank : 252)
Query Neighborhood Hits	537	Target Neighborhood Hits	313	Shared Neighborhood Hits	194
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CSKI1_HUMAN
θ value	0.0148317 (rank : 286)	NC score	0.038665 (rank : 858)
Query Neighborhood Hits	537	Target Neighborhood Hits	997	Shared Neighborhood Hits	70
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

GEMI5_HUMAN
θ value	0.0148317 (rank : 287)	NC score	0.442516 (rank : 174)
Query Neighborhood Hits	537	Target Neighborhood Hits	362	Shared Neighborhood Hits	221
SwissProt Accessions	Q8TEQ6, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5	Gene names	GEMIN5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

STRN_MOUSE
θ value	0.0148317 (rank : 288)	NC score	0.461422 (rank : 159)
Query Neighborhood Hits	537	Target Neighborhood Hits	326	Shared Neighborhood Hits	215
SwissProt Accessions	O55106	Gene names	Strn
Domain Architecture
Description	Striatin.

EPS8_MOUSE
θ value	0.0193708 (rank : 289)	NC score	0.215678 (rank : 393)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	128
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

WDR3_HUMAN
θ value	0.0193708 (rank : 290)	NC score	0.557734 (rank : 85)
Query Neighborhood Hits	537	Target Neighborhood Hits	334	Shared Neighborhood Hits	220
SwissProt Accessions	Q9UNX4	Gene names	WDR3
Domain Architecture
Description	WD repeat protein 3.

GNB1L_MOUSE
θ value	0.0252991 (rank : 291)	NC score	0.488990 (rank : 138)
Query Neighborhood Hits	537	Target Neighborhood Hits	231	Shared Neighborhood Hits	180
SwissProt Accessions	Q9EQ15, Q8R1F3, Q9CWP2, Q9D3Y1	Gene names	Gnb1l, Estm55, Wdr14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF).

NIPBL_HUMAN
θ value	0.0252991 (rank : 292)	NC score	0.032847 (rank : 863)
Query Neighborhood Hits	537	Target Neighborhood Hits	1311	Shared Neighborhood Hits	69
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

TXND2_MOUSE
θ value	0.0252991 (rank : 293)	NC score	0.023032 (rank : 882)
Query Neighborhood Hits	537	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

PEX7_HUMAN
θ value	0.0330416 (rank : 294)	NC score	0.548523 (rank : 97)
Query Neighborhood Hits	537	Target Neighborhood Hits	275	Shared Neighborhood Hits	212
SwissProt Accessions	O00628	Gene names	PEX7, PTS2R
Domain Architecture
Description	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7).

RHG12_HUMAN
θ value	0.0330416 (rank : 295)	NC score	0.075417 (rank : 605)
Query Neighborhood Hits	537	Target Neighborhood Hits	190	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

COR1A_HUMAN
θ value	0.0431538 (rank : 296)	NC score	0.402490 (rank : 227)
Query Neighborhood Hits	537	Target Neighborhood Hits	240	Shared Neighborhood Hits	177
SwissProt Accessions	P31146	Gene names	CORO1A, CORO1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

CRKL_MOUSE
θ value	0.0431538 (rank : 297)	NC score	0.370162 (rank : 265)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	189
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

EPS8_HUMAN
θ value	0.0431538 (rank : 298)	NC score	0.208560 (rank : 402)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	112
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ERCC8_MOUSE
θ value	0.0431538 (rank : 299)	NC score	0.502280 (rank : 122)
Query Neighborhood Hits	537	Target Neighborhood Hits	269	Shared Neighborhood Hits	208
SwissProt Accessions	Q8CFD5, Q3U066, Q8VDC4, Q9CWK7	Gene names	Ercc8, Ckn1, Csa
Domain Architecture	No domain graphic available
Description	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA homolog).

KI21B_HUMAN
θ value	0.0431538 (rank : 300)	NC score	0.237328 (rank : 375)
Query Neighborhood Hits	537	Target Neighborhood Hits	1017	Shared Neighborhood Hits	238
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

NCF1_HUMAN
θ value	0.0431538 (rank : 301)	NC score	0.369292 (rank : 268)
Query Neighborhood Hits	537	Target Neighborhood Hits	198	Shared Neighborhood Hits	161
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PK1IP_MOUSE
θ value	0.0431538 (rank : 302)	NC score	0.508138 (rank : 116)
Query Neighborhood Hits	537	Target Neighborhood Hits	313	Shared Neighborhood Hits	206
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

WDR6_HUMAN
θ value	0.0431538 (rank : 303)	NC score	0.379517 (rank : 250)
Query Neighborhood Hits	537	Target Neighborhood Hits	193	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NNW5, Q9UF63	Gene names	WDR6
Domain Architecture
Description	WD repeat protein 6.

ERCC8_HUMAN
θ value	0.0563607 (rank : 304)	NC score	0.507813 (rank : 117)
Query Neighborhood Hits	537	Target Neighborhood Hits	267	Shared Neighborhood Hits	205
SwissProt Accessions	Q13216, Q6FHX5, Q96GB9	Gene names	ERCC8, CKN1, CSA
Domain Architecture
Description	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA).

GEMI5_MOUSE
θ value	0.0563607 (rank : 305)	NC score	0.436603 (rank : 189)
Query Neighborhood Hits	537	Target Neighborhood Hits	424	Shared Neighborhood Hits	225
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

MIA_HUMAN
θ value	0.0563607 (rank : 306)	NC score	0.115380 (rank : 524)
Query Neighborhood Hits	537	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	0.0563607 (rank : 307)	NC score	0.113533 (rank : 527)
Query Neighborhood Hits	537	Target Neighborhood Hits	17	Shared Neighborhood Hits	16
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

RBBP4_HUMAN
θ value	0.0563607 (rank : 308)	NC score	0.464633 (rank : 155)
Query Neighborhood Hits	537	Target Neighborhood Hits	291	Shared Neighborhood Hits	211
SwissProt Accessions	Q09028, P31149, Q53H02, Q96BV9	Gene names	RBBP4, RBAP48
Domain Architecture
Description	Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome remodeling factor subunit RBAP48).

RBBP4_MOUSE
θ value	0.0563607 (rank : 309)	NC score	0.465820 (rank : 154)
Query Neighborhood Hits	537	Target Neighborhood Hits	289	Shared Neighborhood Hits	210
SwissProt Accessions	Q60972	Gene names	Rbbp4, Rbap48
Domain Architecture
Description	Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome remodeling factor subunit RBAP48).

TCGAP_MOUSE
θ value	0.0563607 (rank : 310)	NC score	0.154052 (rank : 455)
Query Neighborhood Hits	537	Target Neighborhood Hits	409	Shared Neighborhood Hits	129
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

UTP18_MOUSE
θ value	0.0563607 (rank : 311)	NC score	0.273914 (rank : 347)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	98
SwissProt Accessions	Q5SSI6	Gene names	Utp18, Wdr50
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat protein 50).

ABL1_HUMAN
θ value	0.0736092 (rank : 312)	NC score	0.122846 (rank : 505)
Query Neighborhood Hits	537	Target Neighborhood Hits	1220	Shared Neighborhood Hits	152
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	0.0736092 (rank : 313)	NC score	0.122052 (rank : 509)
Query Neighborhood Hits	537	Target Neighborhood Hits	1178	Shared Neighborhood Hits	146
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSKP_HUMAN
θ value	0.0736092 (rank : 314)	NC score	0.048547 (rank : 852)
Query Neighborhood Hits	537	Target Neighborhood Hits	1022	Shared Neighborhood Hits	124
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DBNL_HUMAN
θ value	0.0736092 (rank : 315)	NC score	0.323776 (rank : 315)
Query Neighborhood Hits	537	Target Neighborhood Hits	244	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.0736092 (rank : 316)	NC score	0.319776 (rank : 316)
Query Neighborhood Hits	537	Target Neighborhood Hits	306	Shared Neighborhood Hits	156
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ES8L3_MOUSE
θ value	0.0736092 (rank : 317)	NC score	0.264544 (rank : 348)
Query Neighborhood Hits	537	Target Neighborhood Hits	168	Shared Neighborhood Hits	145
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

MIA2_MOUSE
θ value	0.0736092 (rank : 318)	NC score	0.082107 (rank : 583)
Query Neighborhood Hits	537	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

TEP1_MOUSE
θ value	0.0736092 (rank : 319)	NC score	0.499589 (rank : 127)
Query Neighborhood Hits	537	Target Neighborhood Hits	344	Shared Neighborhood Hits	222
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

WDR20_MOUSE
θ value	0.0736092 (rank : 320)	NC score	0.379494 (rank : 251)
Query Neighborhood Hits	537	Target Neighborhood Hits	217	Shared Neighborhood Hits	168
SwissProt Accessions	Q9D5R2	Gene names	Wdr20
Domain Architecture
Description	WD repeat protein 20.

COPB2_HUMAN
θ value	0.0961366 (rank : 321)	NC score	0.542915 (rank : 99)
Query Neighborhood Hits	537	Target Neighborhood Hits	315	Shared Neighborhood Hits	223
SwissProt Accessions	P35606	Gene names	COPB2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

COPB2_MOUSE
θ value	0.0961366 (rank : 322)	NC score	0.542863 (rank : 100)
Query Neighborhood Hits	537	Target Neighborhood Hits	315	Shared Neighborhood Hits	223
SwissProt Accessions	O55029, Q3U5Z9	Gene names	Copb2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

DC1I2_HUMAN
θ value	0.0961366 (rank : 323)	NC score	0.192686 (rank : 414)
Query Neighborhood Hits	537	Target Neighborhood Hits	201	Shared Neighborhood Hits	117
SwissProt Accessions	Q13409, Q96NG7, Q96S87, Q9BXZ5, Q9NT58	Gene names	DYNC1I2, DNCI2, DNCIC2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

DC1I2_MOUSE
θ value	0.0961366 (rank : 324)	NC score	0.196781 (rank : 408)
Query Neighborhood Hits	537	Target Neighborhood Hits	209	Shared Neighborhood Hits	118
SwissProt Accessions	O88487, Q3TGH7	Gene names	Dync1i2, Dnci2, Dncic2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

DEK_HUMAN
θ value	0.0961366 (rank : 325)	NC score	0.042919 (rank : 855)
Query Neighborhood Hits	537	Target Neighborhood Hits	199	Shared Neighborhood Hits	18
SwissProt Accessions	P35659, Q5TGV4, Q5TGV5	Gene names	DEK
Domain Architecture	No domain graphic available
Description	Protein DEK.

DNMBP_HUMAN
θ value	0.0961366 (rank : 326)	NC score	0.348780 (rank : 297)
Query Neighborhood Hits	537	Target Neighborhood Hits	413	Shared Neighborhood Hits	207
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	0.0961366 (rank : 327)	NC score	0.339192 (rank : 303)
Query Neighborhood Hits	537	Target Neighborhood Hits	435	Shared Neighborhood Hits	202
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

E41L2_HUMAN
θ value	0.0961366 (rank : 328)	NC score	0.010293 (rank : 924)
Query Neighborhood Hits	537	Target Neighborhood Hits	287	Shared Neighborhood Hits	15
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

FOG1_MOUSE
θ value	0.0961366 (rank : 329)	NC score	-0.005315 (rank : 947)
Query Neighborhood Hits	537	Target Neighborhood Hits	1237	Shared Neighborhood Hits	25
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ITK_MOUSE
θ value	0.0961366 (rank : 330)	NC score	0.117349 (rank : 520)
Query Neighborhood Hits	537	Target Neighborhood Hits	985	Shared Neighborhood Hits	134
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SRGP1_HUMAN
θ value	0.0961366 (rank : 331)	NC score	0.194679 (rank : 411)
Query Neighborhood Hits	537	Target Neighborhood Hits	390	Shared Neighborhood Hits	148
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

TBL2_MOUSE
θ value	0.0961366 (rank : 332)	NC score	0.473787 (rank : 145)
Query Neighborhood Hits	537	Target Neighborhood Hits	221	Shared Neighborhood Hits	184
SwissProt Accessions	Q9R099	Gene names	Tbl2
Domain Architecture
Description	Transducin beta-like 2 protein.

TXK_HUMAN
θ value	0.0961366 (rank : 333)	NC score	0.124481 (rank : 500)
Query Neighborhood Hits	537	Target Neighborhood Hits	971	Shared Neighborhood Hits	140
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

WDFY1_HUMAN
θ value	0.0961366 (rank : 334)	NC score	0.404133 (rank : 221)
Query Neighborhood Hits	537	Target Neighborhood Hits	305	Shared Neighborhood Hits	207
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ZF106_HUMAN
θ value	0.0961366 (rank : 335)	NC score	0.402917 (rank : 226)
Query Neighborhood Hits	537	Target Neighborhood Hits	470	Shared Neighborhood Hits	178
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

ABL2_HUMAN
θ value	0.125558 (rank : 336)	NC score	0.119239 (rank : 517)
Query Neighborhood Hits	537	Target Neighborhood Hits	1045	Shared Neighborhood Hits	134
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ARHG5_HUMAN
θ value	0.125558 (rank : 337)	NC score	0.166417 (rank : 442)
Query Neighborhood Hits	537	Target Neighborhood Hits	172	Shared Neighborhood Hits	91
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

CSKP_MOUSE
θ value	0.125558 (rank : 338)	NC score	0.048177 (rank : 854)
Query Neighborhood Hits	537	Target Neighborhood Hits	1027	Shared Neighborhood Hits	130
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DOCK1_HUMAN
θ value	0.125558 (rank : 339)	NC score	0.128370 (rank : 491)
Query Neighborhood Hits	537	Target Neighborhood Hits	191	Shared Neighborhood Hits	116
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ERG_HUMAN
θ value	0.125558 (rank : 340)	NC score	0.015716 (rank : 905)
Query Neighborhood Hits	537	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	P11308, Q16113	Gene names	ERG
Domain Architecture
Description	Transcriptional regulator ERG (Transforming protein ERG).

K0329_HUMAN
θ value	0.125558 (rank : 341)	NC score	0.054026 (rank : 817)
Query Neighborhood Hits	537	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	O15040, Q9UEG6	Gene names	KIAA0329, KIAA0297
Domain Architecture
Description	Protein KIAA0329/KIAA0297.

NUP37_MOUSE
θ value	0.125558 (rank : 342)	NC score	0.364574 (rank : 279)
Query Neighborhood Hits	537	Target Neighborhood Hits	159	Shared Neighborhood Hits	140
SwissProt Accessions	Q9CWU9	Gene names	Nup37
Domain Architecture
Description	Nucleoporin Nup37.

RIMB1_HUMAN
θ value	0.125558 (rank : 343)	NC score	0.131871 (rank : 483)
Query Neighborhood Hits	537	Target Neighborhood Hits	1479	Shared Neighborhood Hits	161
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRGP2_MOUSE
θ value	0.125558 (rank : 344)	NC score	0.205768 (rank : 404)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	156
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CASL_HUMAN
θ value	0.163984 (rank : 345)	NC score	0.260049 (rank : 353)
Query Neighborhood Hits	537	Target Neighborhood Hits	259	Shared Neighborhood Hits	148
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0.163984 (rank : 346)	NC score	0.262345 (rank : 349)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	151
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

IF32_HUMAN
θ value	0.163984 (rank : 347)	NC score	0.501000 (rank : 126)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	189
SwissProt Accessions	Q13347	Gene names	EIF3S2, TRIP1
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 2 (eIF-3 beta) (eIF3 p36) (eIF3i) (TGF-beta receptor-interacting protein 1) (TRIP-1).

IF32_MOUSE
θ value	0.163984 (rank : 348)	NC score	0.501475 (rank : 124)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	189
SwissProt Accessions	Q9QZD9	Gene names	Eif3s2, Trip1
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 2 (eIF-3 beta) (eIF3 p36) (eIF3i) (TGF-beta receptor-interacting protein 1) (TRIP-1).

LYST_HUMAN
θ value	0.163984 (rank : 349)	NC score	0.242423 (rank : 371)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	145
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

LYST_MOUSE
θ value	0.163984 (rank : 350)	NC score	0.227754 (rank : 385)
Query Neighborhood Hits	537	Target Neighborhood Hits	286	Shared Neighborhood Hits	146
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

SRGP2_HUMAN
θ value	0.163984 (rank : 351)	NC score	0.201971 (rank : 405)
Query Neighborhood Hits	537	Target Neighborhood Hits	331	Shared Neighborhood Hits	153
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRMS_MOUSE
θ value	0.163984 (rank : 352)	NC score	0.109423 (rank : 532)
Query Neighborhood Hits	537	Target Neighborhood Hits	964	Shared Neighborhood Hits	117
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

WDR36_HUMAN
θ value	0.163984 (rank : 353)	NC score	0.507149 (rank : 118)
Query Neighborhood Hits	537	Target Neighborhood Hits	274	Shared Neighborhood Hits	210
SwissProt Accessions	Q8NI36, Q8N1Q2	Gene names	WDR36
Domain Architecture
Description	WD repeat protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP).

WDR79_MOUSE
θ value	0.163984 (rank : 354)	NC score	0.448681 (rank : 168)
Query Neighborhood Hits	537	Target Neighborhood Hits	216	Shared Neighborhood Hits	169
SwissProt Accessions	Q8VC51	Gene names	Wdr79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

ZC11A_MOUSE
θ value	0.163984 (rank : 355)	NC score	0.025311 (rank : 876)
Query Neighborhood Hits	537	Target Neighborhood Hits	216	Shared Neighborhood Hits	9
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

DMXL2_HUMAN
θ value	0.21417 (rank : 356)	NC score	0.281879 (rank : 346)
Query Neighborhood Hits	537	Target Neighborhood Hits	374	Shared Neighborhood Hits	178
SwissProt Accessions	Q8TDJ6, O94938	Gene names	DMXL2, KIAA0856
Domain Architecture	No domain graphic available
Description	Protein DmX-like 2 (Rabconnectin-3).

DOCK2_MOUSE
θ value	0.21417 (rank : 357)	NC score	0.055488 (rank : 798)
Query Neighborhood Hits	537	Target Neighborhood Hits	104	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

NPBL_MOUSE
θ value	0.21417 (rank : 358)	NC score	0.036863 (rank : 860)
Query Neighborhood Hits	537	Target Neighborhood Hits	1041	Shared Neighborhood Hits	56
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

OTOR_HUMAN
θ value	0.21417 (rank : 359)	NC score	0.074598 (rank : 612)
Query Neighborhood Hits	537	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRC9	Gene names	OTOR, FDP, MIAL
Domain Architecture
Description	Otoraplin precursor (Fibrocyte-derived protein) (Melanoma inhibitory activity-like protein).

P85A_HUMAN
θ value	0.21417 (rank : 360)	NC score	0.155240 (rank : 452)
Query Neighborhood Hits	537	Target Neighborhood Hits	479	Shared Neighborhood Hits	123
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RHG12_MOUSE
θ value	0.21417 (rank : 361)	NC score	0.076273 (rank : 601)
Query Neighborhood Hits	537	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

AT2B2_MOUSE
θ value	0.279714 (rank : 362)	NC score	0.017944 (rank : 893)
Query Neighborhood Hits	537	Target Neighborhood Hits	68	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0K7, O88863	Gene names	Atp2b2, Pmca2
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2) (Plasma membrane calcium pump isoform 2) (Plasma membrane calcium ATPase isoform 2).

P85A_MOUSE
θ value	0.279714 (rank : 363)	NC score	0.160015 (rank : 449)
Query Neighborhood Hits	537	Target Neighborhood Hits	435	Shared Neighborhood Hits	125
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RUSC1_MOUSE
θ value	0.279714 (rank : 364)	NC score	0.213456 (rank : 396)
Query Neighborhood Hits	537	Target Neighborhood Hits	206	Shared Neighborhood Hits	127
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

TEP1_HUMAN
θ value	0.279714 (rank : 365)	NC score	0.498120 (rank : 130)
Query Neighborhood Hits	537	Target Neighborhood Hits	371	Shared Neighborhood Hits	224
SwissProt Accessions	Q99973	Gene names	TEP1, TLP1, TP1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog).

TXK_MOUSE
θ value	0.279714 (rank : 366)	NC score	0.129248 (rank : 487)
Query Neighborhood Hits	537	Target Neighborhood Hits	980	Shared Neighborhood Hits	151
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

WDR7_MOUSE
θ value	0.279714 (rank : 367)	NC score	0.334429 (rank : 307)
Query Neighborhood Hits	537	Target Neighborhood Hits	226	Shared Neighborhood Hits	173
SwissProt Accessions	Q920I9, Q80TY3, Q920J0	Gene names	Wdr7, Kiaa0541, Trag
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG).

ARHGG_MOUSE
θ value	0.365318 (rank : 368)	NC score	0.143215 (rank : 465)
Query Neighborhood Hits	537	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

CT194_HUMAN
θ value	0.365318 (rank : 369)	NC score	0.024395 (rank : 879)
Query Neighborhood Hits	537	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TEA3, Q66K86, Q6P2R9, Q9UFX9	Gene names	C20orf194
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf194.

KI21B_MOUSE
θ value	0.365318 (rank : 370)	NC score	0.234533 (rank : 380)
Query Neighborhood Hits	537	Target Neighborhood Hits	997	Shared Neighborhood Hits	235
SwissProt Accessions	Q9QXL1, P97424	Gene names	Kif21b, Kif6
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B (Kinesin-like protein KIF6).

MLL3_HUMAN
θ value	0.365318 (rank : 371)	NC score	0.017380 (rank : 896)
Query Neighborhood Hits	537	Target Neighborhood Hits	1644	Shared Neighborhood Hits	75
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NBN_HUMAN
θ value	0.365318 (rank : 372)	NC score	0.027794 (rank : 869)
Query Neighborhood Hits	537	Target Neighborhood Hits	226	Shared Neighborhood Hits	20
SwissProt Accessions	O60934, O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2	Gene names	NBN, NBS, NBS1, P95
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95).

NEDD1_MOUSE
θ value	0.365318 (rank : 373)	NC score	0.445147 (rank : 172)
Query Neighborhood Hits	537	Target Neighborhood Hits	281	Shared Neighborhood Hits	184
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

RBBP7_HUMAN
θ value	0.365318 (rank : 374)	NC score	0.462888 (rank : 157)
Query Neighborhood Hits	537	Target Neighborhood Hits	285	Shared Neighborhood Hits	210
SwissProt Accessions	Q16576	Gene names	RBBP7, RBAP46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

RBBP7_MOUSE
θ value	0.365318 (rank : 375)	NC score	0.462685 (rank : 158)
Query Neighborhood Hits	537	Target Neighborhood Hits	285	Shared Neighborhood Hits	210
SwissProt Accessions	Q60973, Q3UX20	Gene names	Rbbp7, Rbap46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

STRN3_HUMAN
θ value	0.365318 (rank : 376)	NC score	0.448210 (rank : 169)
Query Neighborhood Hits	537	Target Neighborhood Hits	316	Shared Neighborhood Hits	204
SwissProt Accessions	Q13033, Q9NRA5	Gene names	STRN3, GS2NA, SG2NA
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

STRN3_MOUSE
θ value	0.365318 (rank : 377)	NC score	0.447300 (rank : 170)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ERG2	Gene names	Strn3, Gs2na, Sg2na
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

TRIO_HUMAN
θ value	0.365318 (rank : 378)	NC score	0.061987 (rank : 713)
Query Neighborhood Hits	537	Target Neighborhood Hits	1580	Shared Neighborhood Hits	121
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

WDFY3_HUMAN
θ value	0.365318 (rank : 379)	NC score	0.228509 (rank : 384)
Query Neighborhood Hits	537	Target Neighborhood Hits	348	Shared Neighborhood Hits	168
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDR20_HUMAN
θ value	0.365318 (rank : 380)	NC score	0.364841 (rank : 277)
Query Neighborhood Hits	537	Target Neighborhood Hits	249	Shared Neighborhood Hits	172
SwissProt Accessions	Q8TBZ3, Q8WXX2, Q9UF86	Gene names	WDR20
Domain Architecture
Description	WD repeat protein 20 (DMR protein).

WDR31_HUMAN
θ value	0.365318 (rank : 381)	NC score	0.530930 (rank : 106)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	216
SwissProt Accessions	Q8NA23, Q96EG8	Gene names	WDR31
Domain Architecture
Description	WD repeat protein 31.

AMPH_HUMAN
θ value	0.47712 (rank : 382)	NC score	0.124375 (rank : 502)
Query Neighborhood Hits	537	Target Neighborhood Hits	455	Shared Neighborhood Hits	93
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

GRWD1_MOUSE
θ value	0.47712 (rank : 383)	NC score	0.478154 (rank : 143)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	215
SwissProt Accessions	Q810D6, Q922H3	Gene names	Grwd1, A301
Domain Architecture	No domain graphic available
Description	Glutamate-rich WD repeat-containing protein 1 (Protein A301).

SHAN2_MOUSE
θ value	0.47712 (rank : 384)	NC score	0.142208 (rank : 468)
Query Neighborhood Hits	537	Target Neighborhood Hits	446	Shared Neighborhood Hits	109
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

STRN4_MOUSE
θ value	0.47712 (rank : 385)	NC score	0.468465 (rank : 149)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	213
SwissProt Accessions	P58404, Q68EF5	Gene names	Strn4, Zin
Domain Architecture
Description	Striatin-4 (Zinedin).

TCGAP_HUMAN
θ value	0.47712 (rank : 386)	NC score	0.135372 (rank : 477)
Query Neighborhood Hits	537	Target Neighborhood Hits	872	Shared Neighborhood Hits	137
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

WDR16_MOUSE
θ value	0.47712 (rank : 387)	NC score	0.495613 (rank : 136)
Query Neighborhood Hits	537	Target Neighborhood Hits	269	Shared Neighborhood Hits	202
SwissProt Accessions	Q5F201, Q5F200, Q9D432, Q9DA68	Gene names	WDR16
Domain Architecture	No domain graphic available
Description	WD repeat protein 16.

WDR7_HUMAN
θ value	0.47712 (rank : 388)	NC score	0.326489 (rank : 313)
Query Neighborhood Hits	537	Target Neighborhood Hits	244	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

ZF106_MOUSE
θ value	0.47712 (rank : 389)	NC score	0.396276 (rank : 234)
Query Neighborhood Hits	537	Target Neighborhood Hits	472	Shared Neighborhood Hits	185
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

AT2B3_HUMAN
θ value	0.62314 (rank : 390)	NC score	0.016741 (rank : 900)
Query Neighborhood Hits	537	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q16720, Q12995, Q16858	Gene names	ATP2B3
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 3 (EC 3.6.3.8) (PMCA3) (Plasma membrane calcium pump isoform 3) (Plasma membrane calcium ATPase isoform 3).

DMWD_MOUSE
θ value	0.62314 (rank : 391)	NC score	0.363675 (rank : 280)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	170
SwissProt Accessions	Q08274	Gene names	Dmwd, Dm9
Domain Architecture
Description	Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (DMR-N9 protein).

FZR_HUMAN
θ value	0.62314 (rank : 392)	NC score	0.497112 (rank : 134)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UM11, O75869, Q86U66, Q96NW8, Q9UI96, Q9ULH8, Q9UM10, Q9UNQ1, Q9Y2T8	Gene names	FZR1, CDH1, FYR, FZR, KIAA1242
Domain Architecture
Description	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) (hCDH1) (CDC20-like protein 1).

MPP5_HUMAN
θ value	0.62314 (rank : 393)	NC score	0.066140 (rank : 660)
Query Neighborhood Hits	537	Target Neighborhood Hits	231	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.62314 (rank : 394)	NC score	0.065526 (rank : 665)
Query Neighborhood Hits	537	Target Neighborhood Hits	226	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

STTP1_HUMAN
θ value	0.62314 (rank : 395)	NC score	0.401968 (rank : 228)
Query Neighborhood Hits	537	Target Neighborhood Hits	232	Shared Neighborhood Hits	200
SwissProt Accessions	Q6IA86, Q53GZ0, Q687Y8, Q8N5C2, Q96GV4, Q96PI7, Q9H9N0, Q9NV81	Gene names	STATIP1
Domain Architecture	No domain graphic available
Description	Stat3-interacting protein (StIP1) (SHINC-2).

WDR31_MOUSE
θ value	0.62314 (rank : 396)	NC score	0.528757 (rank : 107)
Query Neighborhood Hits	537	Target Neighborhood Hits	287	Shared Neighborhood Hits	217
SwissProt Accessions	Q9JHB4, Q3URZ0, Q9D3N4	Gene names	Wdr31
Domain Architecture
Description	WD repeat protein 31 (Spermatid WD repeat protein) (spWD).

AT2B2_HUMAN
θ value	0.813845 (rank : 397)	NC score	0.017485 (rank : 895)
Query Neighborhood Hits	537	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q01814, O00766, Q12994, Q16818	Gene names	ATP2B2, PMCA2
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2) (Plasma membrane calcium pump isoform 2) (Plasma membrane calcium ATPase isoform 2).

CEP35_HUMAN
θ value	0.813845 (rank : 398)	NC score	0.027234 (rank : 871)
Query Neighborhood Hits	537	Target Neighborhood Hits	811	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CSK_HUMAN
θ value	0.813845 (rank : 399)	NC score	0.120900 (rank : 512)
Query Neighborhood Hits	537	Target Neighborhood Hits	1009	Shared Neighborhood Hits	150
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.813845 (rank : 400)	NC score	0.120761 (rank : 513)
Query Neighborhood Hits	537	Target Neighborhood Hits	1009	Shared Neighborhood Hits	150
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

ES8L3_HUMAN
θ value	0.813845 (rank : 401)	NC score	0.247445 (rank : 364)
Query Neighborhood Hits	537	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HIRA_HUMAN
θ value	0.813845 (rank : 402)	NC score	0.466574 (rank : 152)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	200
SwissProt Accessions	P54198, Q8IXN2	Gene names	HIRA, DGCR1, HIR, TUPLE1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

HIRA_MOUSE
θ value	0.813845 (rank : 403)	NC score	0.468366 (rank : 150)
Query Neighborhood Hits	537	Target Neighborhood Hits	274	Shared Neighborhood Hits	199
SwissProt Accessions	Q61666, O08845, Q62365	Gene names	Hira, Tuple1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

RIMB1_MOUSE
θ value	0.813845 (rank : 404)	NC score	0.125960 (rank : 495)
Query Neighborhood Hits	537	Target Neighborhood Hits	1376	Shared Neighborhood Hits	177
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SNX18_HUMAN
θ value	0.813845 (rank : 405)	NC score	0.212319 (rank : 398)
Query Neighborhood Hits	537	Target Neighborhood Hits	207	Shared Neighborhood Hits	129
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0.813845 (rank : 406)	NC score	0.218128 (rank : 392)
Query Neighborhood Hits	537	Target Neighborhood Hits	198	Shared Neighborhood Hits	128
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

STRN4_HUMAN
θ value	0.813845 (rank : 407)	NC score	0.469523 (rank : 148)
Query Neighborhood Hits	537	Target Neighborhood Hits	325	Shared Neighborhood Hits	216
SwissProt Accessions	Q9NRL3	Gene names	STRN4, ZIN
Domain Architecture
Description	Striatin-4 (Zinedin).

WDR24_HUMAN
θ value	0.813845 (rank : 408)	NC score	0.337968 (rank : 304)
Query Neighborhood Hits	537	Target Neighborhood Hits	247	Shared Neighborhood Hits	175
SwissProt Accessions	Q96S15, Q96GC7, Q9H0B7	Gene names	WDR24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

CDC20_MOUSE
θ value	1.06291 (rank : 409)	NC score	0.508145 (rank : 115)
Query Neighborhood Hits	537	Target Neighborhood Hits	325	Shared Neighborhood Hits	208
SwissProt Accessions	Q9JJ66, Q3TGP1, Q8BPG4, Q99LK3	Gene names	Cdc20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC) (mmCdc20).

CIR1A_MOUSE
θ value	1.06291 (rank : 410)	NC score	0.253868 (rank : 359)
Query Neighborhood Hits	537	Target Neighborhood Hits	155	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R2N2, Q62306, Q69Z48, Q6NVG9, Q8VEL5	Gene names	Cirh1a, Kiaa1988, Tex292
Domain Architecture	No domain graphic available
Description	Cirhin (Testis-expressed gene 292 protein).

CK5P2_HUMAN
θ value	1.06291 (rank : 411)	NC score	0.022192 (rank : 885)
Query Neighborhood Hits	537	Target Neighborhood Hits	1433	Shared Neighborhood Hits	81
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

ERC2_MOUSE
θ value	1.06291 (rank : 412)	NC score	0.027692 (rank : 870)
Query Neighborhood Hits	537	Target Neighborhood Hits	1166	Shared Neighborhood Hits	63
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

GOGA4_HUMAN
θ value	1.06291 (rank : 413)	NC score	0.022399 (rank : 883)
Query Neighborhood Hits	537	Target Neighborhood Hits	2034	Shared Neighborhood Hits	96
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GRWD1_HUMAN
θ value	1.06291 (rank : 414)	NC score	0.477285 (rank : 144)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	215
SwissProt Accessions	Q9BQ67	Gene names	GRWD1, GRWD, WDR28
Domain Architecture
Description	Glutamate-rich WD repeat-containing protein 1.

KMHN1_MOUSE
θ value	1.06291 (rank : 415)	NC score	0.023168 (rank : 881)
Query Neighborhood Hits	537	Target Neighborhood Hits	949	Shared Neighborhood Hits	64
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

NEDD1_HUMAN
θ value	1.06291 (rank : 416)	NC score	0.439408 (rank : 179)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	185
SwissProt Accessions	Q8NHV4, Q8NA30	Gene names	NEDD1
Domain Architecture	No domain graphic available
Description	Protein NEDD1.

THOC6_MOUSE
θ value	1.06291 (rank : 417)	NC score	0.371047 (rank : 261)
Query Neighborhood Hits	537	Target Neighborhood Hits	199	Shared Neighborhood Hits	163
SwissProt Accessions	Q5U4D9	Gene names	Thoc6, Wdr58
Domain Architecture	No domain graphic available
Description	THO complex subunit 6 homolog (WD repeat protein 58).

TLE1_HUMAN
θ value	1.06291 (rank : 418)	NC score	0.354482 (rank : 287)
Query Neighborhood Hits	537	Target Neighborhood Hits	485	Shared Neighborhood Hits	217
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE1_MOUSE
θ value	1.06291 (rank : 419)	NC score	0.354177 (rank : 288)
Query Neighborhood Hits	537	Target Neighborhood Hits	491	Shared Neighborhood Hits	218
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

TLE4_HUMAN
θ value	1.06291 (rank : 420)	NC score	0.361666 (rank : 282)
Query Neighborhood Hits	537	Target Neighborhood Hits	477	Shared Neighborhood Hits	212
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

TLE4_MOUSE
θ value	1.06291 (rank : 421)	NC score	0.362129 (rank : 281)
Query Neighborhood Hits	537	Target Neighborhood Hits	482	Shared Neighborhood Hits	213
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

UBP36_HUMAN
θ value	1.06291 (rank : 422)	NC score	0.008207 (rank : 932)
Query Neighborhood Hits	537	Target Neighborhood Hits	232	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

CYLC1_HUMAN
θ value	1.38821 (rank : 423)	NC score	0.033159 (rank : 861)
Query Neighborhood Hits	537	Target Neighborhood Hits	408	Shared Neighborhood Hits	28
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

EMAL4_HUMAN
θ value	1.38821 (rank : 424)	NC score	0.359283 (rank : 283)
Query Neighborhood Hits	537	Target Neighborhood Hits	306	Shared Neighborhood Hits	197
SwissProt Accessions	Q9HC35	Gene names	EML4, C2orf2, EMAPL4
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120).

ERC2_HUMAN
θ value	1.38821 (rank : 425)	NC score	0.025933 (rank : 874)
Query Neighborhood Hits	537	Target Neighborhood Hits	1156	Shared Neighborhood Hits	60
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERG_MOUSE
θ value	1.38821 (rank : 426)	NC score	0.012136 (rank : 917)
Query Neighborhood Hits	537	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	P81270, Q8C5L4, Q920K7, Q920K8, Q920K9	Gene names	Erg, Erg-3
Domain Architecture
Description	Transcriptional regulator ERG.

FANCJ_MOUSE
θ value	1.38821 (rank : 427)	NC score	0.012853 (rank : 914)
Query Neighborhood Hits	537	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SXJ3, Q8BJQ8, Q8BKI6	Gene names	Brip1, Bach1, Fancj
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

FZR_MOUSE
θ value	1.38821 (rank : 428)	NC score	0.497298 (rank : 132)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	211
SwissProt Accessions	Q9R1K5	Gene names	Fzr1, Fyr, Fzr
Domain Architecture
Description	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog).

MRCKG_HUMAN
θ value	1.38821 (rank : 429)	NC score	0.025763 (rank : 875)
Query Neighborhood Hits	537	Target Neighborhood Hits	1519	Shared Neighborhood Hits	90
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

STS1_HUMAN
θ value	1.38821 (rank : 430)	NC score	0.113612 (rank : 525)
Query Neighborhood Hits	537	Target Neighborhood Hits	106	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

WDR24_MOUSE
θ value	1.38821 (rank : 431)	NC score	0.429219 (rank : 195)
Query Neighborhood Hits	537	Target Neighborhood Hits	286	Shared Neighborhood Hits	193
SwissProt Accessions	Q8CFJ9	Gene names	Wdr24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

AMPH_MOUSE
θ value	1.81305 (rank : 432)	NC score	0.110626 (rank : 531)
Query Neighborhood Hits	537	Target Neighborhood Hits	291	Shared Neighborhood Hits	78
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BOP1_HUMAN
θ value	1.81305 (rank : 433)	NC score	0.357750 (rank : 284)
Query Neighborhood Hits	537	Target Neighborhood Hits	257	Shared Neighborhood Hits	187
SwissProt Accessions	Q14137, Q969Z6, Q96IS8, Q9BSA7, Q9BVM0	Gene names	BOP1, KIAA0124
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

CDC20_HUMAN
θ value	1.81305 (rank : 434)	NC score	0.509181 (rank : 112)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	208
SwissProt Accessions	Q12834, Q9BW56, Q9UQI9	Gene names	CDC20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC).

CEP63_HUMAN
θ value	1.81305 (rank : 435)	NC score	0.025076 (rank : 877)
Query Neighborhood Hits	537	Target Neighborhood Hits	1005	Shared Neighborhood Hits	55
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

EM55_HUMAN
θ value	1.81305 (rank : 436)	NC score	0.087538 (rank : 572)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	90
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

OTOR_MOUSE
θ value	1.81305 (rank : 437)	NC score	0.065917 (rank : 662)
Query Neighborhood Hits	537	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JIE3	Gene names	Otor, Mial
Domain Architecture
Description	Otoraplin precursor (Melanoma inhibitory activity-like protein).

SLAP2_MOUSE
θ value	1.81305 (rank : 438)	NC score	0.218541 (rank : 390)
Query Neighborhood Hits	537	Target Neighborhood Hits	136	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

THOC6_HUMAN
θ value	1.81305 (rank : 439)	NC score	0.400038 (rank : 230)
Query Neighborhood Hits	537	Target Neighborhood Hits	223	Shared Neighborhood Hits	181
SwissProt Accessions	Q86W42, Q8NBR1, Q9BTV9	Gene names	THOC6, WDR58
Domain Architecture	No domain graphic available
Description	THO complex subunit 6 homolog (WD repeat protein 58).

TOP2B_HUMAN
θ value	1.81305 (rank : 440)	NC score	0.010917 (rank : 920)
Query Neighborhood Hits	537	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q02880, Q13600, Q9UMG8, Q9UQP8	Gene names	TOP2B
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

WDR16_HUMAN
θ value	1.81305 (rank : 441)	NC score	0.491989 (rank : 137)
Query Neighborhood Hits	537	Target Neighborhood Hits	275	Shared Neighborhood Hits	205
SwissProt Accessions	Q8N1V2, Q5DX23, Q8TC73, Q8TCI3	Gene names	WDR16, WDRPUH
Domain Architecture	No domain graphic available
Description	WD repeat protein 16 (WD40-repeat protein up-regulated in HCC).

WDR47_HUMAN
θ value	1.81305 (rank : 442)	NC score	0.504682 (rank : 120)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	204
SwissProt Accessions	O94967, Q8IXT7, Q8IYU9	Gene names	WDR47, KIAA0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

WDR47_MOUSE
θ value	1.81305 (rank : 443)	NC score	0.504594 (rank : 121)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	203
SwissProt Accessions	Q8CGF6, Q80TP4	Gene names	Wdr47, Kiaa0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

ZN638_HUMAN
θ value	1.81305 (rank : 444)	NC score	0.012656 (rank : 915)
Query Neighborhood Hits	537	Target Neighborhood Hits	343	Shared Neighborhood Hits	23
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

ADA30_HUMAN
θ value	2.36792 (rank : 445)	NC score	0.001177 (rank : 945)
Query Neighborhood Hits	537	Target Neighborhood Hits	391	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

AP3D1_HUMAN
θ value	2.36792 (rank : 446)	NC score	0.014540 (rank : 909)
Query Neighborhood Hits	537	Target Neighborhood Hits	254	Shared Neighborhood Hits	20
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

ARHGG_HUMAN
θ value	2.36792 (rank : 447)	NC score	0.126610 (rank : 494)
Query Neighborhood Hits	537	Target Neighborhood Hits	129	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

AT2B1_HUMAN
θ value	2.36792 (rank : 448)	NC score	0.015533 (rank : 906)
Query Neighborhood Hits	537	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082	Gene names	ATP2B1, PMCA1
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 1 (EC 3.6.3.8) (PMCA1) (Plasma membrane calcium pump isoform 1) (Plasma membrane calcium ATPase isoform 1).

CASC5_MOUSE
θ value	2.36792 (rank : 449)	NC score	0.014832 (rank : 908)
Query Neighborhood Hits	537	Target Neighborhood Hits	70	Shared Neighborhood Hits	7
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

CF060_HUMAN
θ value	2.36792 (rank : 450)	NC score	0.017979 (rank : 892)
Query Neighborhood Hits	537	Target Neighborhood Hits	1270	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

DOCK2_HUMAN
θ value	2.36792 (rank : 451)	NC score	0.048240 (rank : 853)
Query Neighborhood Hits	537	Target Neighborhood Hits	90	Shared Neighborhood Hits	43
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

IWS1_MOUSE
θ value	2.36792 (rank : 452)	NC score	0.020800 (rank : 887)
Query Neighborhood Hits	537	Target Neighborhood Hits	1258	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MYBB_HUMAN
θ value	2.36792 (rank : 453)	NC score	0.009947 (rank : 925)
Query Neighborhood Hits	537	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	P10244	Gene names	MYBL2, BMYB
Domain Architecture
Description	Myb-related protein B (B-Myb).

NUP37_HUMAN
θ value	2.36792 (rank : 454)	NC score	0.314875 (rank : 322)
Query Neighborhood Hits	537	Target Neighborhood Hits	153	Shared Neighborhood Hits	137
SwissProt Accessions	Q8NFH4, Q9H644	Gene names	NUP37
Domain Architecture
Description	Nucleoporin Nup37 (p37).

RIF1_HUMAN
θ value	2.36792 (rank : 455)	NC score	0.017979 (rank : 891)
Query Neighborhood Hits	537	Target Neighborhood Hits	320	Shared Neighborhood Hits	27
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

SNX9_HUMAN
θ value	2.36792 (rank : 456)	NC score	0.135389 (rank : 476)
Query Neighborhood Hits	537	Target Neighborhood Hits	148	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

DPOLZ_MOUSE
θ value	3.0926 (rank : 457)	NC score	0.010677 (rank : 922)
Query Neighborhood Hits	537	Target Neighborhood Hits	169	Shared Neighborhood Hits	11
SwissProt Accessions	Q61493, Q9JMD6, Q9QWX6	Gene names	Rev3l, Polz, Sez4
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Seizure-related protein 4).

GABP2_HUMAN
θ value	3.0926 (rank : 458)	NC score	0.016045 (rank : 903)
Query Neighborhood Hits	537	Target Neighborhood Hits	454	Shared Neighborhood Hits	25
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

HDAC1_HUMAN
θ value	3.0926 (rank : 459)	NC score	0.007842 (rank : 934)
Query Neighborhood Hits	537	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q13547, Q92534	Gene names	HDAC1, RPD3L1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

IFT74_HUMAN
θ value	3.0926 (rank : 460)	NC score	0.021840 (rank : 886)
Query Neighborhood Hits	537	Target Neighborhood Hits	949	Shared Neighborhood Hits	53
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

KIT_MOUSE
θ value	3.0926 (rank : 461)	NC score	0.064049 (rank : 683)
Query Neighborhood Hits	537	Target Neighborhood Hits	949	Shared Neighborhood Hits	48
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

MORC3_HUMAN
θ value	3.0926 (rank : 462)	NC score	0.014209 (rank : 911)
Query Neighborhood Hits	537	Target Neighborhood Hits	489	Shared Neighborhood Hits	31
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

PASK_MOUSE
θ value	3.0926 (rank : 463)	NC score	0.023587 (rank : 880)
Query Neighborhood Hits	537	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PCSK5_MOUSE
θ value	3.0926 (rank : 464)	NC score	-0.004578 (rank : 946)
Query Neighborhood Hits	537	Target Neighborhood Hits	613	Shared Neighborhood Hits	3
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

SFR11_HUMAN
θ value	3.0926 (rank : 465)	NC score	0.030671 (rank : 866)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q05519	Gene names	SFRS11
Domain Architecture
Description	Splicing factor arginine/serine-rich 11 (Arginine-rich 54 kDa nuclear protein) (p54).

SLAP2_HUMAN
θ value	3.0926 (rank : 466)	NC score	0.215579 (rank : 394)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

T2FA_HUMAN
θ value	3.0926 (rank : 467)	NC score	0.029090 (rank : 868)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	19
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

WDR53_HUMAN
θ value	3.0926 (rank : 468)	NC score	0.456801 (rank : 162)
Query Neighborhood Hits	537	Target Neighborhood Hits	251	Shared Neighborhood Hits	205
SwissProt Accessions	Q7Z5U6	Gene names	WDR53
Domain Architecture	No domain graphic available
Description	WD repeat protein 53.

ACM2_HUMAN
θ value	4.03905 (rank : 469)	NC score	-0.012828 (rank : 949)
Query Neighborhood Hits	537	Target Neighborhood Hits	930	Shared Neighborhood Hits	5
SwissProt Accessions	P08172, Q9P1X9	Gene names	CHRM2
Domain Architecture
Description	Muscarinic acetylcholine receptor M2.

ANK2_HUMAN
θ value	4.03905 (rank : 470)	NC score	0.019152 (rank : 890)
Query Neighborhood Hits	537	Target Neighborhood Hits	1615	Shared Neighborhood Hits	86
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CSTF1_MOUSE
θ value	4.03905 (rank : 471)	NC score	0.509146 (rank : 113)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	211
SwissProt Accessions	Q99LC2, Q3UMB8, Q8BJW1, Q9CSU8	Gene names	Cstf1
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit) (CF-1 50 kDa subunit) (CstF-50).

CUL4B_HUMAN
θ value	4.03905 (rank : 472)	NC score	0.004263 (rank : 941)
Query Neighborhood Hits	537	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

DC1I1_HUMAN
θ value	4.03905 (rank : 473)	NC score	0.148853 (rank : 459)
Query Neighborhood Hits	537	Target Neighborhood Hits	183	Shared Neighborhood Hits	95
SwissProt Accessions	O14576, Q9Y2X1	Gene names	DYNC1I1, DNCI1, DNCIC1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

DLG4_MOUSE
θ value	4.03905 (rank : 474)	NC score	0.038403 (rank : 859)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	65
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

GABP2_MOUSE
θ value	4.03905 (rank : 475)	NC score	0.016010 (rank : 904)
Query Neighborhood Hits	537	Target Neighborhood Hits	429	Shared Neighborhood Hits	25
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

HDAC1_MOUSE
θ value	4.03905 (rank : 476)	NC score	0.007278 (rank : 935)
Query Neighborhood Hits	537	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O09106, P97476	Gene names	Hdac1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

PEX13_HUMAN
θ value	4.03905 (rank : 477)	NC score	0.226217 (rank : 386)
Query Neighborhood Hits	537	Target Neighborhood Hits	128	Shared Neighborhood Hits	113
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	4.03905 (rank : 478)	NC score	0.222245 (rank : 389)
Query Neighborhood Hits	537	Target Neighborhood Hits	126	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RFC1_MOUSE
θ value	4.03905 (rank : 479)	NC score	0.013471 (rank : 912)
Query Neighborhood Hits	537	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

RUFY2_MOUSE
θ value	4.03905 (rank : 480)	NC score	0.022237 (rank : 884)
Query Neighborhood Hits	537	Target Neighborhood Hits	820	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

STS1_MOUSE
θ value	4.03905 (rank : 481)	NC score	0.106435 (rank : 533)
Query Neighborhood Hits	537	Target Neighborhood Hits	104	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

WDFY2_HUMAN
θ value	4.03905 (rank : 482)	NC score	0.387706 (rank : 241)
Query Neighborhood Hits	537	Target Neighborhood Hits	332	Shared Neighborhood Hits	217
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

ACM2_MOUSE
θ value	5.27518 (rank : 483)	NC score	-0.013185 (rank : 950)
Query Neighborhood Hits	537	Target Neighborhood Hits	905	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ERZ4	Gene names	Chrm2, Chrm-2
Domain Architecture
Description	Muscarinic acetylcholine receptor M2.

CIR1A_HUMAN
θ value	5.27518 (rank : 484)	NC score	0.257234 (rank : 354)
Query Neighborhood Hits	537	Target Neighborhood Hits	158	Shared Neighborhood Hits	125
SwissProt Accessions	Q969X6, Q8NCD9, Q8TF14, Q96SP0, Q96SR9, Q96SZ9, Q96T13, Q9BWK6	Gene names	CIRH1A, KIAA1988
Domain Architecture
Description	Cirhin.

EAA3_HUMAN
θ value	5.27518 (rank : 485)	NC score	0.003157 (rank : 943)
Query Neighborhood Hits	537	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P43005, O75587, Q5VZ24, Q8N199, Q9UEW2	Gene names	SLC1A1, EAAC1, EAAT3
Domain Architecture
Description	Excitatory amino acid transporter 3 (Sodium-dependent glutamate/aspartate transporter 3) (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter).

EM55_MOUSE
θ value	5.27518 (rank : 486)	NC score	0.083464 (rank : 579)
Query Neighborhood Hits	537	Target Neighborhood Hits	221	Shared Neighborhood Hits	87
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

K0513_MOUSE
θ value	5.27518 (rank : 487)	NC score	0.010590 (rank : 923)
Query Neighborhood Hits	537	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R0A7, Q80TY8, Q8BQV3, Q8C8N9, Q8CCN0	Gene names	Kiaa0513
Domain Architecture	No domain graphic available
Description	Protein KIAA0513.

KI67_HUMAN
θ value	5.27518 (rank : 488)	NC score	0.016245 (rank : 901)
Query Neighborhood Hits	537	Target Neighborhood Hits	581	Shared Neighborhood Hits	35
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

KINH_HUMAN
θ value	5.27518 (rank : 489)	NC score	0.016947 (rank : 898)
Query Neighborhood Hits	537	Target Neighborhood Hits	1231	Shared Neighborhood Hits	64
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

MRCKB_MOUSE
θ value	5.27518 (rank : 490)	NC score	0.033154 (rank : 862)
Query Neighborhood Hits	537	Target Neighborhood Hits	2180	Shared Neighborhood Hits	123
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NOXO1_HUMAN
θ value	5.27518 (rank : 491)	NC score	0.167413 (rank : 441)
Query Neighborhood Hits	537	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NPM_MOUSE
θ value	5.27518 (rank : 492)	NC score	0.009816 (rank : 927)
Query Neighborhood Hits	537	Target Neighborhood Hits	69	Shared Neighborhood Hits	8
SwissProt Accessions	Q61937	Gene names	Npm1
Domain Architecture
Description	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38).

PLCB4_HUMAN
θ value	5.27518 (rank : 493)	NC score	0.039060 (rank : 857)
Query Neighborhood Hits	537	Target Neighborhood Hits	658	Shared Neighborhood Hits	44
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

RPGR_HUMAN
θ value	5.27518 (rank : 494)	NC score	0.006528 (rank : 937)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	20
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

STK10_HUMAN
θ value	5.27518 (rank : 495)	NC score	0.031887 (rank : 864)
Query Neighborhood Hits	537	Target Neighborhood Hits	1921	Shared Neighborhood Hits	102
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TLE3_HUMAN
θ value	5.27518 (rank : 496)	NC score	0.354133 (rank : 289)
Query Neighborhood Hits	537	Target Neighborhood Hits	385	Shared Neighborhood Hits	210
SwissProt Accessions	Q04726, Q8IVV6, Q8WVR2, Q9HCM5	Gene names	TLE3, KIAA1547
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG3).

TLE3_MOUSE
θ value	5.27518 (rank : 497)	NC score	0.355330 (rank : 286)
Query Neighborhood Hits	537	Target Neighborhood Hits	378	Shared Neighborhood Hits	209
SwissProt Accessions	Q08122, Q923A4	Gene names	Tle3, Esg
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG) (Grg-3).

TRI25_MOUSE
θ value	5.27518 (rank : 498)	NC score	0.001281 (rank : 944)
Query Neighborhood Hits	537	Target Neighborhood Hits	446	Shared Neighborhood Hits	17
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

WDR34_MOUSE
θ value	5.27518 (rank : 499)	NC score	0.124225 (rank : 503)
Query Neighborhood Hits	537	Target Neighborhood Hits	105	Shared Neighborhood Hits	79
SwissProt Accessions	Q5U4F6	Gene names	Wdr34
Domain Architecture	No domain graphic available
Description	WD repeat protein 34.

ATBF1_MOUSE
θ value	6.88961 (rank : 500)	NC score	-0.009680 (rank : 948)
Query Neighborhood Hits	537	Target Neighborhood Hits	1841	Shared Neighborhood Hits	48
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

BID_MOUSE
θ value	6.88961 (rank : 501)	NC score	0.012257 (rank : 916)
Query Neighborhood Hits	537	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	P70444, Q99M39	Gene names	Bid
Domain Architecture
Description	BH3-interacting domain death agonist (BID) (p22 BID) [Contains: BH3- interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)].

CCD16_MOUSE
θ value	6.88961 (rank : 502)	NC score	0.009742 (rank : 928)
Query Neighborhood Hits	537	Target Neighborhood Hits	218	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R1N0, Q3TR52, Q9CWV9, Q9CYI6	Gene names	Ccdc16, Omcg1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 16 (Ovus mutant candidate gene 1 protein).

CP135_HUMAN
θ value	6.88961 (rank : 503)	NC score	0.017342 (rank : 897)
Query Neighborhood Hits	537	Target Neighborhood Hits	1290	Shared Neighborhood Hits	60
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

DC1I1_MOUSE
θ value	6.88961 (rank : 504)	NC score	0.141070 (rank : 470)
Query Neighborhood Hits	537	Target Neighborhood Hits	206	Shared Neighborhood Hits	96
SwissProt Accessions	O88485, O88486	Gene names	Dync1i1, Dnci1, Dncic1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

DCR1C_MOUSE
θ value	6.88961 (rank : 505)	NC score	0.007192 (rank : 936)
Query Neighborhood Hits	537	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4J0, Q8BG72, Q8BTT1	Gene names	Dclre1c, Art, Snm1l
Domain Architecture	No domain graphic available
Description	Artemis protein (EC 3.1.-.-) (DNA cross-link repair 1C protein) (mArt protein) (SNM1-like protein).

HIP1_HUMAN
θ value	6.88961 (rank : 506)	NC score	0.010993 (rank : 919)
Query Neighborhood Hits	537	Target Neighborhood Hits	1016	Shared Neighborhood Hits	49
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

K0586_HUMAN
θ value	6.88961 (rank : 507)	NC score	0.009493 (rank : 929)
Query Neighborhood Hits	537	Target Neighborhood Hits	311	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

MADCA_HUMAN
θ value	6.88961 (rank : 508)	NC score	0.013426 (rank : 913)
Query Neighborhood Hits	537	Target Neighborhood Hits	221	Shared Neighborhood Hits	15
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

PRG4_MOUSE
θ value	6.88961 (rank : 509)	NC score	0.010701 (rank : 921)
Query Neighborhood Hits	537	Target Neighborhood Hits	624	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RAPH1_HUMAN
θ value	6.88961 (rank : 510)	NC score	0.016073 (rank : 902)
Query Neighborhood Hits	537	Target Neighborhood Hits	593	Shared Neighborhood Hits	39
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RFWD2_HUMAN
θ value	6.88961 (rank : 511)	NC score	0.411303 (rank : 206)
Query Neighborhood Hits	537	Target Neighborhood Hits	518	Shared Neighborhood Hits	198
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RFWD2_MOUSE
θ value	6.88961 (rank : 512)	NC score	0.410680 (rank : 208)
Query Neighborhood Hits	537	Target Neighborhood Hits	535	Shared Neighborhood Hits	199
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

SGP50_MOUSE
θ value	6.88961 (rank : 513)	NC score	0.017679 (rank : 894)
Query Neighborhood Hits	537	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q02596	Gene names	Glycam1
Domain Architecture
Description	Sulfated 50 kDa glycoprotein precursor (SGP50) (Endothelial ligand FOR L-selectin) (Glycosylation-dependent cell adhesion molecule 1) (GlyCAM-1) (MC26).

WDFY2_MOUSE
θ value	6.88961 (rank : 514)	NC score	0.384055 (rank : 242)
Query Neighborhood Hits	537	Target Neighborhood Hits	337	Shared Neighborhood Hits	217
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

ZFP3_HUMAN
θ value	6.88961 (rank : 515)	NC score	-0.015466 (rank : 951)
Query Neighborhood Hits	537	Target Neighborhood Hits	750	Shared Neighborhood Hits	5
SwissProt Accessions	Q96NJ6	Gene names	ZFP3
Domain Architecture	No domain graphic available
Description	Zinc finger protein 3 homolog (Zfp-3).

BRCA2_HUMAN
θ value	8.99809 (rank : 516)	NC score	0.005737 (rank : 938)
Query Neighborhood Hits	537	Target Neighborhood Hits	202	Shared Neighborhood Hits	13
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

CCD21_HUMAN
θ value	8.99809 (rank : 517)	NC score	0.020090 (rank : 889)
Query Neighborhood Hits	537	Target Neighborhood Hits	1228	Shared Neighborhood Hits	66
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CLK3_HUMAN
θ value	8.99809 (rank : 518)	NC score	0.026779 (rank : 873)
Query Neighborhood Hits	537	Target Neighborhood Hits	748	Shared Neighborhood Hits	49
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	8.99809 (rank : 519)	NC score	0.026829 (rank : 872)
Query Neighborhood Hits	537	Target Neighborhood Hits	761	Shared Neighborhood Hits	50
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CSKI2_HUMAN
θ value	8.99809 (rank : 520)	NC score	0.031188 (rank : 865)
Query Neighborhood Hits	537	Target Neighborhood Hits	747	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

GTF2I_HUMAN
θ value	8.99809 (rank : 521)	NC score	0.004953 (rank : 939)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	8
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

HTSF1_HUMAN
θ value	8.99809 (rank : 522)	NC score	0.009908 (rank : 926)
Query Neighborhood Hits	537	Target Neighborhood Hits	408	Shared Neighborhood Hits	22
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

HUWE1_HUMAN
θ value	8.99809 (rank : 523)	NC score	0.003497 (rank : 942)
Query Neighborhood Hits	537	Target Neighborhood Hits	443	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

INVO_MOUSE
θ value	8.99809 (rank : 524)	NC score	0.020163 (rank : 888)
Query Neighborhood Hits	537	Target Neighborhood Hits	474	Shared Neighborhood Hits	30
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

KIF5C_HUMAN
θ value	8.99809 (rank : 525)	NC score	0.016852 (rank : 899)
Query Neighborhood Hits	537	Target Neighborhood Hits	974	Shared Neighborhood Hits	57
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KIF5C_MOUSE
θ value	8.99809 (rank : 526)	NC score	0.015439 (rank : 907)
Query Neighborhood Hits	537	Target Neighborhood Hits	1040	Shared Neighborhood Hits	56
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

LEO1_HUMAN
θ value	8.99809 (rank : 527)	NC score	0.004280 (rank : 940)
Query Neighborhood Hits	537	Target Neighborhood Hits	958	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MAP1B_MOUSE
θ value	8.99809 (rank : 528)	NC score	0.024961 (rank : 878)
Query Neighborhood Hits	537	Target Neighborhood Hits	977	Shared Neighborhood Hits	72
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MBP_HUMAN
θ value	8.99809 (rank : 529)	NC score	0.008619 (rank : 931)
Query Neighborhood Hits	537	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	P02686, Q15337, Q15338, Q15339, Q15340, Q6AI64, Q6FH37, Q6FI04, Q6PK23	Gene names	MBP
Domain Architecture
Description	Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein).

NOXO1_MOUSE
θ value	8.99809 (rank : 530)	NC score	0.209789 (rank : 400)
Query Neighborhood Hits	537	Target Neighborhood Hits	114	Shared Neighborhood Hits	102
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PACS1_HUMAN
θ value	8.99809 (rank : 531)	NC score	0.008133 (rank : 933)
Query Neighborhood Hits	537	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q6VY07, Q6PJY6, Q6PKB6, Q7Z590, Q7Z5W4, Q8N8K6, Q96MW0, Q9NW92, Q9ULP5	Gene names	PACS1, KIAA1175
Domain Architecture	No domain graphic available
Description	Phosphofurin acidic cluster sorting protein 1 (PACS-1).

PACS1_MOUSE
θ value	8.99809 (rank : 532)	NC score	0.008879 (rank : 930)
Query Neighborhood Hits	537	Target Neighborhood Hits	87	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K212, Q6P5H8	Gene names	Pacs1
Domain Architecture	No domain graphic available
Description	Phosphofurin acidic cluster sorting protein 1 (PACS-1).

RUSC2_HUMAN
θ value	8.99809 (rank : 533)	NC score	0.089607 (rank : 568)
Query Neighborhood Hits	537	Target Neighborhood Hits	205	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SFR16_HUMAN
θ value	8.99809 (rank : 534)	NC score	0.014457 (rank : 910)
Query Neighborhood Hits	537	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N2M8, O96026, Q6UW71, Q96DX2	Gene names	SFRS16, SWAP2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2).

TNR6A_HUMAN
θ value	8.99809 (rank : 535)	NC score	0.011545 (rank : 918)
Query Neighborhood Hits	537	Target Neighborhood Hits	343	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

WIPI3_HUMAN
θ value	8.99809 (rank : 536)	NC score	0.061004 (rank : 735)
Query Neighborhood Hits	537	Target Neighborhood Hits	53	Shared Neighborhood Hits	33
SwissProt Accessions	Q5MNZ6, O95328, Q6IBN2	Gene names	WDR45L, WIPI3
Domain Architecture	No domain graphic available
Description	WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat protein 45-like) (WDR45-like protein) (WIPI49-like protein).

WIPI3_MOUSE
θ value	8.99809 (rank : 537)	NC score	0.061493 (rank : 726)
Query Neighborhood Hits	537	Target Neighborhood Hits	51	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CR39, Q3U924	Gene names	Wdr45l, Wipi3
Domain Architecture	No domain graphic available
Description	WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat protein 45-like) (WDR45-like protein).

AAAS_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.245970 (rank : 367)
Query Neighborhood Hits	537	Target Neighborhood Hits	154	Shared Neighborhood Hits	125
SwissProt Accessions	Q9NRG9, Q9NWI6, Q9UG19	Gene names	AAAS, ADRACALA
Domain Architecture
Description	Aladin (Adracalin).

AAAS_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.206127 (rank : 403)
Query Neighborhood Hits	537	Target Neighborhood Hits	144	Shared Neighborhood Hits	115
SwissProt Accessions	P58742, Q544M6	Gene names	Aaas
Domain Architecture
Description	Aladin (Adracalin).

AATK_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.063814 (rank : 686)
Query Neighborhood Hits	537	Target Neighborhood Hits	1243	Shared Neighborhood Hits	56
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.065652 (rank : 663)
Query Neighborhood Hits	537	Target Neighborhood Hits	942	Shared Neighborhood Hits	54
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABR_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.058327 (rank : 770)
Query Neighborhood Hits	537	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACK1_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.075663 (rank : 604)
Query Neighborhood Hits	537	Target Neighborhood Hits	1140	Shared Neighborhood Hits	86
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.076806 (rank : 598)
Query Neighborhood Hits	537	Target Neighborhood Hits	1080	Shared Neighborhood Hits	91
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ALK_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.068947 (rank : 643)
Query Neighborhood Hits	537	Target Neighborhood Hits	795	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.069458 (rank : 639)
Query Neighborhood Hits	537	Target Neighborhood Hits	811	Shared Neighborhood Hits	50
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ANPRA_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.058057 (rank : 773)
Query Neighborhood Hits	537	Target Neighborhood Hits	612	Shared Neighborhood Hits	39
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.058299 (rank : 771)
Query Neighborhood Hits	537	Target Neighborhood Hits	600	Shared Neighborhood Hits	39
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.053841 (rank : 820)
Query Neighborhood Hits	537	Target Neighborhood Hits	646	Shared Neighborhood Hits	42
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.054707 (rank : 809)
Query Neighborhood Hits	537	Target Neighborhood Hits	607	Shared Neighborhood Hits	42
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

APS_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.094437 (rank : 559)
Query Neighborhood Hits	537	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.070298 (rank : 633)
Query Neighborhood Hits	537	Target Neighborhood Hits	134	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARAF_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.055878 (rank : 787)
Query Neighborhood Hits	537	Target Neighborhood Hits	924	Shared Neighborhood Hits	57
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.056158 (rank : 782)
Query Neighborhood Hits	537	Target Neighborhood Hits	874	Shared Neighborhood Hits	55
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARC1A_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.165766 (rank : 443)
Query Neighborhood Hits	537	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	Q92747, Q7Z5U8, Q86WU5, Q8IXQ0	Gene names	ARPC1A, SOP2L
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein).

ARC1A_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.164348 (rank : 446)
Query Neighborhood Hits	537	Target Neighborhood Hits	120	Shared Neighborhood Hits	102
SwissProt Accessions	Q9R0Q6, Q3UL75	Gene names	Arpc1a, Sid329
Domain Architecture	No domain graphic available
Description	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) (Sid 329).

ARC1B_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.196247 (rank : 410)
Query Neighborhood Hits	537	Target Neighborhood Hits	148	Shared Neighborhood Hits	125
SwissProt Accessions	O15143, Q9BU00	Gene names	ARPC1B, ARC41
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1B (ARP2/3 complex 41 kDa subunit) (p41-ARC).

ARC1B_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.179735 (rank : 428)
Query Neighborhood Hits	537	Target Neighborhood Hits	133	Shared Neighborhood Hits	112
SwissProt Accessions	Q9WV32	Gene names	Arpc1b
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1B (ARP2/3 complex 41 kDa subunit) (p41-ARC).

ARHG1_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.074611 (rank : 611)
Query Neighborhood Hits	537	Target Neighborhood Hits	176	Shared Neighborhood Hits	23
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.062949 (rank : 697)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.062155 (rank : 712)
Query Neighborhood Hits	537	Target Neighborhood Hits	142	Shared Neighborhood Hits	31
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.061963 (rank : 715)
Query Neighborhood Hits	537	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.099694 (rank : 548)
Query Neighborhood Hits	537	Target Neighborhood Hits	82	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.099755 (rank : 547)
Query Neighborhood Hits	537	Target Neighborhood Hits	85	Shared Neighborhood Hits	28
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.092769 (rank : 564)
Query Neighborhood Hits	537	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.099793 (rank : 546)
Query Neighborhood Hits	537	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.081347 (rank : 584)
Query Neighborhood Hits	537	Target Neighborhood Hits	187	Shared Neighborhood Hits	28
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.085357 (rank : 577)
Query Neighborhood Hits	537	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.073392 (rank : 616)
Query Neighborhood Hits	537	Target Neighborhood Hits	375	Shared Neighborhood Hits	35
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.072026 (rank : 624)
Query Neighborhood Hits	537	Target Neighborhood Hits	351	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.072026 (rank : 623)
Query Neighborhood Hits	537	Target Neighborhood Hits	344	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.083255 (rank : 580)
Query Neighborhood Hits	537	Target Neighborhood Hits	214	Shared Neighborhood Hits	31
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

BAIP2_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.058943 (rank : 762)
Query Neighborhood Hits	537	Target Neighborhood Hits	192	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.059937 (rank : 755)
Query Neighborhood Hits	537	Target Neighborhood Hits	185	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR3_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.054255 (rank : 814)
Query Neighborhood Hits	537	Target Neighborhood Hits	129	Shared Neighborhood Hits	41
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.053000 (rank : 825)
Query Neighborhood Hits	537	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.065334 (rank : 667)
Query Neighborhood Hits	537	Target Neighborhood Hits	204	Shared Neighborhood Hits	37
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.081019 (rank : 586)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.066567 (rank : 652)
Query Neighborhood Hits	537	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.100920 (rank : 544)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	89
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 581)	NC score	0.094901 (rank : 557)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	87
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLNK_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.054194 (rank : 815)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 583)	NC score	0.059254 (rank : 760)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMR1A_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.050074 (rank : 851)
Query Neighborhood Hits	537	Target Neighborhood Hits	759	Shared Neighborhood Hits	45
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 585)	NC score	0.050229 (rank : 850)
Query Neighborhood Hits	537	Target Neighborhood Hits	758	Shared Neighborhood Hits	45
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.050851 (rank : 848)
Query Neighborhood Hits	537	Target Neighborhood Hits	760	Shared Neighborhood Hits	42
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.051173 (rank : 840)
Query Neighborhood Hits	537	Target Neighborhood Hits	758	Shared Neighborhood Hits	42
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 588)	NC score	0.086930 (rank : 574)
Query Neighborhood Hits	537	Target Neighborhood Hits	942	Shared Neighborhood Hits	69
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 589)	NC score	0.087153 (rank : 573)
Query Neighborhood Hits	537	Target Neighborhood Hits	912	Shared Neighborhood Hits	68
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BOP1_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.370820 (rank : 262)
Query Neighborhood Hits	537	Target Neighborhood Hits	267	Shared Neighborhood Hits	192
SwissProt Accessions	P97452, Q3TK87, Q91X31	Gene names	Bop1
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

BRAF1_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.055281 (rank : 800)
Query Neighborhood Hits	537	Target Neighborhood Hits	883	Shared Neighborhood Hits	57
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BRWD2_HUMAN
θ value	θ > 10 (rank : 592)	NC score	0.124629 (rank : 499)
Query Neighborhood Hits	537	Target Neighborhood Hits	94	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BZH6, Q5VWA1	Gene names	BRWD2, WDR11
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 2 (WD repeat protein 11).

BUB3_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.403246 (rank : 224)
Query Neighborhood Hits	537	Target Neighborhood Hits	200	Shared Neighborhood Hits	163
SwissProt Accessions	O43684, O43685	Gene names	BUB3
Domain Architecture
Description	Mitotic checkpoint protein BUB3.

BUB3_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.393300 (rank : 235)
Query Neighborhood Hits	537	Target Neighborhood Hits	199	Shared Neighborhood Hits	163
SwissProt Accessions	Q9WVA3, P97397	Gene names	Bub3
Domain Architecture
Description	Mitotic checkpoint protein BUB3 (WD repeat type I transmembrane protein A72.5).

CHIN_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.065030 (rank : 670)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.066381 (rank : 654)
Query Neighborhood Hits	537	Target Neighborhood Hits	229	Shared Neighborhood Hits	59
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.063823 (rank : 685)
Query Neighborhood Hits	537	Target Neighborhood Hits	220	Shared Neighborhood Hits	54
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.128518 (rank : 489)
Query Neighborhood Hits	537	Target Neighborhood Hits	374	Shared Neighborhood Hits	94
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CSF1R_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.064178 (rank : 680)
Query Neighborhood Hits	537	Target Neighborhood Hits	943	Shared Neighborhood Hits	48
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.061365 (rank : 729)
Query Neighborhood Hits	537	Target Neighborhood Hits	983	Shared Neighborhood Hits	48
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSTF1_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.502254 (rank : 123)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	210
SwissProt Accessions	Q05048	Gene names	CSTF1
Domain Architecture
Description	Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit) (CF-1 50 kDa subunit) (CstF-50).

DAPP1_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.122582 (rank : 506)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.122368 (rank : 508)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDB2_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.310693 (rank : 325)
Query Neighborhood Hits	537	Target Neighborhood Hits	175	Shared Neighborhood Hits	135
SwissProt Accessions	Q92466, Q76E54, Q76E55, Q76E56, Q76E57	Gene names	DDB2
Domain Architecture
Description	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) (DDB p48 subunit) (DDBb) (UV-damaged DNA-binding protein 2) (UV-DDB 2).

DDB2_MOUSE
θ value	θ > 10 (rank : 605)	NC score	0.306734 (rank : 328)
Query Neighborhood Hits	537	Target Neighborhood Hits	175	Shared Neighborhood Hits	141
SwissProt Accessions	Q99J79	Gene names	Ddb2
Domain Architecture	No domain graphic available
Description	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2).

DDR1_HUMAN
θ value	θ > 10 (rank : 606)	NC score	0.066592 (rank : 651)
Query Neighborhood Hits	537	Target Neighborhood Hits	819	Shared Neighborhood Hits	48
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 607)	NC score	0.067245 (rank : 650)
Query Neighborhood Hits	537	Target Neighborhood Hits	818	Shared Neighborhood Hits	46
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.063206 (rank : 694)
Query Neighborhood Hits	537	Target Neighborhood Hits	818	Shared Neighborhood Hits	49
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 609)	NC score	0.062700 (rank : 701)
Query Neighborhood Hits	537	Target Neighborhood Hits	813	Shared Neighborhood Hits	45
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DMXL1_HUMAN
θ value	θ > 10 (rank : 610)	NC score	0.218538 (rank : 391)
Query Neighborhood Hits	537	Target Neighborhood Hits	259	Shared Neighborhood Hits	167
SwissProt Accessions	Q9Y485	Gene names	DMXL1, XL1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

DMXL1_MOUSE
θ value	θ > 10 (rank : 611)	NC score	0.250274 (rank : 362)
Query Neighborhood Hits	537	Target Neighborhood Hits	257	Shared Neighborhood Hits	171
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

DNAI1_HUMAN
θ value	θ > 10 (rank : 612)	NC score	0.181558 (rank : 422)
Query Neighborhood Hits	537	Target Neighborhood Hits	148	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UI46, Q9UEZ8	Gene names	DNAI1
Domain Architecture
Description	Dynein intermediate chain 1, axonemal (Axonemal dynein intermediate chain 1).

DNAI2_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.171034 (rank : 433)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	104
SwissProt Accessions	Q9GZS0, Q9H179, Q9NT53	Gene names	DNAI2
Domain Architecture
Description	Dynein intermediate chain 2, axonemal (Axonemal dynein intermediate chain 2).

ECT2_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.078686 (rank : 591)
Query Neighborhood Hits	537	Target Neighborhood Hits	98	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 615)	NC score	0.081075 (rank : 585)
Query Neighborhood Hits	537	Target Neighborhood Hits	98	Shared Neighborhood Hits	28
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EGFR_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.061726 (rank : 722)
Query Neighborhood Hits	537	Target Neighborhood Hits	939	Shared Neighborhood Hits	46
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.061722 (rank : 723)
Query Neighborhood Hits	537	Target Neighborhood Hits	927	Shared Neighborhood Hits	46
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EMAL1_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.349910 (rank : 294)
Query Neighborhood Hits	537	Target Neighborhood Hits	214	Shared Neighborhood Hits	177
SwissProt Accessions	O00423	Gene names	EML1, EMAP1, EMAPL, EMAPL1
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1).

EMAL2_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.368960 (rank : 270)
Query Neighborhood Hits	537	Target Neighborhood Hits	217	Shared Neighborhood Hits	176
SwissProt Accessions	O95834, Q9UG50	Gene names	EML2, EMAP2, EMAPL2
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2).

EPHA1_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.063076 (rank : 695)
Query Neighborhood Hits	537	Target Neighborhood Hits	997	Shared Neighborhood Hits	51
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.063401 (rank : 691)
Query Neighborhood Hits	537	Target Neighborhood Hits	958	Shared Neighborhood Hits	50
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.061522 (rank : 725)
Query Neighborhood Hits	537	Target Neighborhood Hits	1021	Shared Neighborhood Hits	52
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.061755 (rank : 721)
Query Neighborhood Hits	537	Target Neighborhood Hits	1020	Shared Neighborhood Hits	52
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.058510 (rank : 767)
Query Neighborhood Hits	537	Target Neighborhood Hits	1005	Shared Neighborhood Hits	50
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.058557 (rank : 766)
Query Neighborhood Hits	537	Target Neighborhood Hits	1009	Shared Neighborhood Hits	51
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.059979 (rank : 753)
Query Neighborhood Hits	537	Target Neighborhood Hits	975	Shared Neighborhood Hits	50
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.059967 (rank : 754)
Query Neighborhood Hits	537	Target Neighborhood Hits	982	Shared Neighborhood Hits	51
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.060017 (rank : 752)
Query Neighborhood Hits	537	Target Neighborhood Hits	1009	Shared Neighborhood Hits	51
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.063056 (rank : 696)
Query Neighborhood Hits	537	Target Neighborhood Hits	950	Shared Neighborhood Hits	51
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.063440 (rank : 690)
Query Neighborhood Hits	537	Target Neighborhood Hits	959	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.063281 (rank : 693)
Query Neighborhood Hits	537	Target Neighborhood Hits	946	Shared Neighborhood Hits	49
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.058709 (rank : 765)
Query Neighborhood Hits	537	Target Neighborhood Hits	1053	Shared Neighborhood Hits	52
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.058845 (rank : 764)
Query Neighborhood Hits	537	Target Neighborhood Hits	1025	Shared Neighborhood Hits	52
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.060380 (rank : 748)
Query Neighborhood Hits	537	Target Neighborhood Hits	956	Shared Neighborhood Hits	48
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 635)	NC score	0.060597 (rank : 743)
Query Neighborhood Hits	537	Target Neighborhood Hits	969	Shared Neighborhood Hits	49
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.066358 (rank : 656)
Query Neighborhood Hits	537	Target Neighborhood Hits	960	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.059582 (rank : 757)
Query Neighborhood Hits	537	Target Neighborhood Hits	988	Shared Neighborhood Hits	52
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.060939 (rank : 737)
Query Neighborhood Hits	537	Target Neighborhood Hits	983	Shared Neighborhood Hits	52
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.060778 (rank : 740)
Query Neighborhood Hits	537	Target Neighborhood Hits	982	Shared Neighborhood Hits	52
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.061196 (rank : 733)
Query Neighborhood Hits	537	Target Neighborhood Hits	996	Shared Neighborhood Hits	54
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.061345 (rank : 730)
Query Neighborhood Hits	537	Target Neighborhood Hits	996	Shared Neighborhood Hits	54
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.060972 (rank : 736)
Query Neighborhood Hits	537	Target Neighborhood Hits	1056	Shared Neighborhood Hits	51
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.060840 (rank : 739)
Query Neighborhood Hits	537	Target Neighborhood Hits	1013	Shared Neighborhood Hits	51
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.065940 (rank : 661)
Query Neighborhood Hits	537	Target Neighborhood Hits	912	Shared Neighborhood Hits	47
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.065054 (rank : 669)
Query Neighborhood Hits	537	Target Neighborhood Hits	906	Shared Neighborhood Hits	47
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.064099 (rank : 681)
Query Neighborhood Hits	537	Target Neighborhood Hits	1073	Shared Neighborhood Hits	54
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.064280 (rank : 676)
Query Neighborhood Hits	537	Target Neighborhood Hits	918	Shared Neighborhood Hits	47
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.064401 (rank : 672)
Query Neighborhood Hits	537	Target Neighborhood Hits	918	Shared Neighborhood Hits	45
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.064090 (rank : 682)
Query Neighborhood Hits	537	Target Neighborhood Hits	898	Shared Neighborhood Hits	46
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.064212 (rank : 677)
Query Neighborhood Hits	537	Target Neighborhood Hits	910	Shared Neighborhood Hits	51
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

FAK1_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.062509 (rank : 704)
Query Neighborhood Hits	537	Target Neighborhood Hits	850	Shared Neighborhood Hits	47
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.062587 (rank : 703)
Query Neighborhood Hits	537	Target Neighborhood Hits	850	Shared Neighborhood Hits	49
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 653)	NC score	0.065604 (rank : 664)
Query Neighborhood Hits	537	Target Neighborhood Hits	847	Shared Neighborhood Hits	48
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 654)	NC score	0.065382 (rank : 666)
Query Neighborhood Hits	537	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FARP1_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.051376 (rank : 838)
Query Neighborhood Hits	537	Target Neighborhood Hits	241	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.051297 (rank : 839)
Query Neighborhood Hits	537	Target Neighborhood Hits	240	Shared Neighborhood Hits	28
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 657)	NC score	0.055506 (rank : 797)
Query Neighborhood Hits	537	Target Neighborhood Hits	209	Shared Neighborhood Hits	30
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FBXW2_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.501469 (rank : 125)
Query Neighborhood Hits	537	Target Neighborhood Hits	260	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UKT8, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3	Gene names	FBXW2, FBW2, FWD2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

FBXW2_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.497123 (rank : 133)
Query Neighborhood Hits	537	Target Neighborhood Hits	249	Shared Neighborhood Hits	197
SwissProt Accessions	Q60584	Gene names	Fbxw2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

FBXW4_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.329413 (rank : 310)
Query Neighborhood Hits	537	Target Neighborhood Hits	209	Shared Neighborhood Hits	154
SwissProt Accessions	P57775, Q5SVS1, Q96IM6	Gene names	FBXW4, FBW4, SHFM3
Domain Architecture
Description	F-box/WD repeat protein 4 (F-box and WD-40 domain protein 4) (Dactylin).

FBXW4_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.344809 (rank : 299)
Query Neighborhood Hits	537	Target Neighborhood Hits	205	Shared Neighborhood Hits	152
SwissProt Accessions	Q9JMJ2, Q9QXW3	Gene names	Fbxw4, Fbw4
Domain Architecture
Description	F-box/WD repeat protein 4 (F-box and WD-40 domain protein 4) (Hagoromo protein).

FBXW5_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.235126 (rank : 379)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	121
SwissProt Accessions	Q969U6, Q5SPZ8, Q5SPZ9, Q5SQ02, Q5SQ03, Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, Q9H6A8, Q9HBQ6, Q9NSZ3	Gene names	FBXW5, FBW5
Domain Architecture
Description	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5).

FBXW5_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.250609 (rank : 361)
Query Neighborhood Hits	537	Target Neighborhood Hits	159	Shared Neighborhood Hits	123
SwissProt Accessions	Q9QXW2	Gene names	Fbxw5, Fbw5
Domain Architecture
Description	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5).

FBXW8_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.209462 (rank : 401)
Query Neighborhood Hits	537	Target Neighborhood Hits	192	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N3Y1, Q9UK95	Gene names	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8) (F-box only protein 29).

FBXW8_MOUSE
θ value	θ > 10 (rank : 665)	NC score	0.181252 (rank : 424)
Query Neighborhood Hits	537	Target Neighborhood Hits	162	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BIA4, Q8BI62, Q8BI75, Q8BI76, Q8CID8, Q921Z1	Gene names	Fbxw8
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8).

FBXW9_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.391595 (rank : 237)
Query Neighborhood Hits	537	Target Neighborhood Hits	184	Shared Neighborhood Hits	142
SwissProt Accessions	Q5XUX1, Q9BT89	Gene names	FBXW9, FBW9
Domain Architecture	No domain graphic available
Description	F-box/WD repeat protein 9 (F-box and WD-40 domain protein 9).

FER_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.082825 (rank : 581)
Query Neighborhood Hits	537	Target Neighborhood Hits	1278	Shared Neighborhood Hits	105
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.070063 (rank : 636)
Query Neighborhood Hits	537	Target Neighborhood Hits	978	Shared Neighborhood Hits	67
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.067729 (rank : 646)
Query Neighborhood Hits	537	Target Neighborhood Hits	980	Shared Neighborhood Hits	59
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.062598 (rank : 702)
Query Neighborhood Hits	537	Target Neighborhood Hits	367	Shared Neighborhood Hits	43
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 671)	NC score	0.061220 (rank : 731)
Query Neighborhood Hits	537	Target Neighborhood Hits	387	Shared Neighborhood Hits	44
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.069173 (rank : 641)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 673)	NC score	0.066302 (rank : 657)
Query Neighborhood Hits	537	Target Neighborhood Hits	163	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.066440 (rank : 653)
Query Neighborhood Hits	537	Target Neighborhood Hits	249	Shared Neighborhood Hits	32
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.072139 (rank : 622)
Query Neighborhood Hits	537	Target Neighborhood Hits	257	Shared Neighborhood Hits	37
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.073152 (rank : 617)
Query Neighborhood Hits	537	Target Neighborhood Hits	219	Shared Neighborhood Hits	36
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 677)	NC score	0.073668 (rank : 613)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.053928 (rank : 818)
Query Neighborhood Hits	537	Target Neighborhood Hits	237	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.057410 (rank : 777)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	35
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGFR1_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.054996 (rank : 805)
Query Neighborhood Hits	537	Target Neighborhood Hits	1069	Shared Neighborhood Hits	47
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 681)	NC score	0.055000 (rank : 804)
Query Neighborhood Hits	537	Target Neighborhood Hits	1068	Shared Neighborhood Hits	47
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.055277 (rank : 802)
Query Neighborhood Hits	537	Target Neighborhood Hits	1062	Shared Neighborhood Hits	47
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 683)	NC score	0.055636 (rank : 791)
Query Neighborhood Hits	537	Target Neighborhood Hits	1062	Shared Neighborhood Hits	47
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.056100 (rank : 783)
Query Neighborhood Hits	537	Target Neighborhood Hits	1042	Shared Neighborhood Hits	47
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.055694 (rank : 790)
Query Neighborhood Hits	537	Target Neighborhood Hits	1059	Shared Neighborhood Hits	47
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.057953 (rank : 774)
Query Neighborhood Hits	537	Target Neighborhood Hits	1037	Shared Neighborhood Hits	47
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 687)	NC score	0.059372 (rank : 758)
Query Neighborhood Hits	537	Target Neighborhood Hits	1026	Shared Neighborhood Hits	46
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLT3_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.064880 (rank : 671)
Query Neighborhood Hits	537	Target Neighborhood Hits	843	Shared Neighborhood Hits	47
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 689)	NC score	0.065256 (rank : 668)
Query Neighborhood Hits	537	Target Neighborhood Hits	847	Shared Neighborhood Hits	47
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

GNB1L_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.428732 (rank : 196)
Query Neighborhood Hits	537	Target Neighborhood Hits	221	Shared Neighborhood Hits	169
SwissProt Accessions	Q9BYB4, Q9H2S2, Q9H4M4	Gene names	GNB1L, GY2, KIAA1645, WDR14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF) (DGCRK3).

GNRP_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.055518 (rank : 795)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 692)	NC score	0.064337 (rank : 675)
Query Neighborhood Hits	537	Target Neighborhood Hits	191	Shared Neighborhood Hits	27
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.073649 (rank : 614)
Query Neighborhood Hits	537	Target Neighborhood Hits	147	Shared Neighborhood Hits	54
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 694)	NC score	0.075055 (rank : 609)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	54
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.099450 (rank : 550)
Query Neighborhood Hits	537	Target Neighborhood Hits	137	Shared Neighborhood Hits	55
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 696)	NC score	0.101886 (rank : 541)
Query Neighborhood Hits	537	Target Neighborhood Hits	149	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.078659 (rank : 592)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	55
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 698)	NC score	0.086666 (rank : 575)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	57
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GUC2C_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.054672 (rank : 810)
Query Neighborhood Hits	537	Target Neighborhood Hits	624	Shared Neighborhood Hits	39
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.051101 (rank : 842)
Query Neighborhood Hits	537	Target Neighborhood Hits	715	Shared Neighborhood Hits	42
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.051002 (rank : 845)
Query Neighborhood Hits	537	Target Neighborhood Hits	692	Shared Neighborhood Hits	42
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.057737 (rank : 776)
Query Neighborhood Hits	537	Target Neighborhood Hits	740	Shared Neighborhood Hits	43
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 703)	NC score	0.054933 (rank : 808)
Query Neighborhood Hits	537	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HAPIP_HUMAN
θ value	θ > 10 (rank : 704)	NC score	0.075840 (rank : 602)
Query Neighborhood Hits	537	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HSH2D_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.097547 (rank : 553)
Query Neighborhood Hits	537	Target Neighborhood Hits	159	Shared Neighborhood Hits	48
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.060389 (rank : 747)
Query Neighborhood Hits	537	Target Neighborhood Hits	124	Shared Neighborhood Hits	35
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IF140_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.066171 (rank : 659)
Query Neighborhood Hits	537	Target Neighborhood Hits	111	Shared Neighborhood Hits	57
SwissProt Accessions	Q96RY7, O60332	Gene names	IFT140, KIAA0590, WDTC2
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 140 homolog (WD and tetratricopeptide repeats protein 2).

IFT80_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.330429 (rank : 308)
Query Neighborhood Hits	537	Target Neighborhood Hits	195	Shared Neighborhood Hits	154
SwissProt Accessions	Q9P2H3	Gene names	IFT80, KIAA1374, WDR56
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 80 homolog (WD repeat protein 56).

IFT80_MOUSE
θ value	θ > 10 (rank : 709)	NC score	0.336668 (rank : 306)
Query Neighborhood Hits	537	Target Neighborhood Hits	200	Shared Neighborhood Hits	154
SwissProt Accessions	Q8K057	Gene names	Ift80, Wdr56
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 80 homolog (WD repeat protein 56).

IGF1R_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.064192 (rank : 678)
Query Neighborhood Hits	537	Target Neighborhood Hits	977	Shared Neighborhood Hits	49
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 711)	NC score	0.064386 (rank : 673)
Query Neighborhood Hits	537	Target Neighborhood Hits	973	Shared Neighborhood Hits	48
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ILK1_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.071441 (rank : 627)
Query Neighborhood Hits	537	Target Neighborhood Hits	857	Shared Neighborhood Hits	60
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.070884 (rank : 629)
Query Neighborhood Hits	537	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 714)	NC score	0.071627 (rank : 625)
Query Neighborhood Hits	537	Target Neighborhood Hits	858	Shared Neighborhood Hits	60
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INSRR_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.064340 (rank : 674)
Query Neighborhood Hits	537	Target Neighborhood Hits	950	Shared Neighborhood Hits	52
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.064014 (rank : 684)
Query Neighborhood Hits	537	Target Neighborhood Hits	961	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.062453 (rank : 707)
Query Neighborhood Hits	537	Target Neighborhood Hits	963	Shared Neighborhood Hits	49
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.062385 (rank : 709)
Query Neighborhood Hits	537	Target Neighborhood Hits	968	Shared Neighborhood Hits	48
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK1_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.050315 (rank : 849)
Query Neighborhood Hits	537	Target Neighborhood Hits	820	Shared Neighborhood Hits	47
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.052338 (rank : 829)
Query Neighborhood Hits	537	Target Neighborhood Hits	784	Shared Neighborhood Hits	46
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.053034 (rank : 824)
Query Neighborhood Hits	537	Target Neighborhood Hits	714	Shared Neighborhood Hits	49
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.055739 (rank : 789)
Query Neighborhood Hits	537	Target Neighborhood Hits	644	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 723)	NC score	0.058880 (rank : 763)
Query Neighborhood Hits	537	Target Neighborhood Hits	628	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

JAK1_HUMAN
θ value	θ > 10 (rank : 724)	NC score	0.056425 (rank : 780)
Query Neighborhood Hits	537	Target Neighborhood Hits	858	Shared Neighborhood Hits	51
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 725)	NC score	0.055523 (rank : 794)
Query Neighborhood Hits	537	Target Neighborhood Hits	854	Shared Neighborhood Hits	48
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.051463 (rank : 836)
Query Neighborhood Hits	537	Target Neighborhood Hits	847	Shared Neighborhood Hits	48
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 727)	NC score	0.051460 (rank : 837)
Query Neighborhood Hits	537	Target Neighborhood Hits	839	Shared Neighborhood Hits	47
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.053859 (rank : 819)
Query Neighborhood Hits	537	Target Neighborhood Hits	827	Shared Neighborhood Hits	47
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 729)	NC score	0.051019 (rank : 844)
Query Neighborhood Hits	537	Target Neighborhood Hits	821	Shared Neighborhood Hits	47
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KI21A_HUMAN
θ value	θ > 10 (rank : 730)	NC score	0.214799 (rank : 395)
Query Neighborhood Hits	537	Target Neighborhood Hits	1543	Shared Neighborhood Hits	244
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

KI21A_MOUSE
θ value	θ > 10 (rank : 731)	NC score	0.210908 (rank : 399)
Query Neighborhood Hits	537	Target Neighborhood Hits	1317	Shared Neighborhood Hits	232
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

KIT_HUMAN
θ value	θ > 10 (rank : 732)	NC score	0.061800 (rank : 719)
Query Neighborhood Hits	537	Target Neighborhood Hits	953	Shared Neighborhood Hits	47
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSR1_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.052677 (rank : 826)
Query Neighborhood Hits	537	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.051504 (rank : 835)
Query Neighborhood Hits	537	Target Neighborhood Hits	870	Shared Neighborhood Hits	53
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.052642 (rank : 827)
Query Neighborhood Hits	537	Target Neighborhood Hits	920	Shared Neighborhood Hits	53
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 736)	NC score	0.077173 (rank : 596)
Query Neighborhood Hits	537	Target Neighborhood Hits	901	Shared Neighborhood Hits	72
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 737)	NC score	0.078039 (rank : 595)
Query Neighborhood Hits	537	Target Neighborhood Hits	944	Shared Neighborhood Hits	75
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 738)	NC score	0.060529 (rank : 744)
Query Neighborhood Hits	537	Target Neighborhood Hits	90	Shared Neighborhood Hits	25
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.070277 (rank : 634)
Query Neighborhood Hits	537	Target Neighborhood Hits	531	Shared Neighborhood Hits	60
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.077002 (rank : 597)
Query Neighborhood Hits	537	Target Neighborhood Hits	177	Shared Neighborhood Hits	45
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.086220 (rank : 576)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.082623 (rank : 582)
Query Neighborhood Hits	537	Target Neighborhood Hits	132	Shared Neighborhood Hits	47
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRBA_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.121672 (rank : 511)
Query Neighborhood Hits	537	Target Neighborhood Hits	196	Shared Neighborhood Hits	91
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

LTK_HUMAN
θ value	θ > 10 (rank : 744)	NC score	0.070436 (rank : 632)
Query Neighborhood Hits	537	Target Neighborhood Hits	774	Shared Neighborhood Hits	49
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 745)	NC score	0.070076 (rank : 635)
Query Neighborhood Hits	537	Target Neighborhood Hits	770	Shared Neighborhood Hits	48
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K12_HUMAN
θ value	θ > 10 (rank : 746)	NC score	0.052151 (rank : 831)
Query Neighborhood Hits	537	Target Neighborhood Hits	940	Shared Neighborhood Hits	54
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 747)	NC score	0.052026 (rank : 832)
Query Neighborhood Hits	537	Target Neighborhood Hits	957	Shared Neighborhood Hits	52
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.052368 (rank : 828)
Query Neighborhood Hits	537	Target Neighborhood Hits	911	Shared Neighborhood Hits	52
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

MATK_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.091823 (rank : 565)
Query Neighborhood Hits	537	Target Neighborhood Hits	954	Shared Neighborhood Hits	92
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.091746 (rank : 566)
Query Neighborhood Hits	537	Target Neighborhood Hits	952	Shared Neighborhood Hits	96
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.105217 (rank : 535)
Query Neighborhood Hits	537	Target Neighborhood Hits	255	Shared Neighborhood Hits	54
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.088124 (rank : 571)
Query Neighborhood Hits	537	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MEP50_HUMAN
θ value	θ > 10 (rank : 753)	NC score	0.403132 (rank : 225)
Query Neighborhood Hits	537	Target Neighborhood Hits	268	Shared Neighborhood Hits	188
SwissProt Accessions	Q9BQA1, Q96GK4, Q9BWY3	Gene names	WDR77, MEP50
Domain Architecture
Description	Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).

MEP50_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.406141 (rank : 217)
Query Neighborhood Hits	537	Target Neighborhood Hits	271	Shared Neighborhood Hits	193
SwissProt Accessions	Q99J09, Q3TFJ1, Q8BSH8, Q9CZY5	Gene names	Wdr77, Mep50
Domain Architecture
Description	Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).

MERTK_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.061826 (rank : 718)
Query Neighborhood Hits	537	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 756)	NC score	0.061372 (rank : 728)
Query Neighborhood Hits	537	Target Neighborhood Hits	974	Shared Neighborhood Hits	43
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.060846 (rank : 738)
Query Neighborhood Hits	537	Target Neighborhood Hits	831	Shared Neighborhood Hits	46
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.061022 (rank : 734)
Query Neighborhood Hits	537	Target Neighborhood Hits	844	Shared Neighborhood Hits	45
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MLKL_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.062373 (rank : 710)
Query Neighborhood Hits	537	Target Neighborhood Hits	600	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 760)	NC score	0.059831 (rank : 756)
Query Neighborhood Hits	537	Target Neighborhood Hits	707	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.055880 (rank : 786)
Query Neighborhood Hits	537	Target Neighborhood Hits	911	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 762)	NC score	0.055906 (rank : 785)
Query Neighborhood Hits	537	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.055033 (rank : 803)
Query Neighborhood Hits	537	Target Neighborhood Hits	829	Shared Neighborhood Hits	47
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.054962 (rank : 807)
Query Neighborhood Hits	537	Target Neighborhood Hits	833	Shared Neighborhood Hits	49
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MPP2_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.054968 (rank : 806)
Query Neighborhood Hits	537	Target Neighborhood Hits	173	Shared Neighborhood Hits	67
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.054346 (rank : 813)
Query Neighborhood Hits	537	Target Neighborhood Hits	189	Shared Neighborhood Hits	66
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 767)	NC score	0.051678 (rank : 834)
Query Neighborhood Hits	537	Target Neighborhood Hits	188	Shared Neighborhood Hits	58
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP6_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.075694 (rank : 603)
Query Neighborhood Hits	537	Target Neighborhood Hits	180	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 769)	NC score	0.075385 (rank : 606)
Query Neighborhood Hits	537	Target Neighborhood Hits	187	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MUSK_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.056651 (rank : 779)
Query Neighborhood Hits	537	Target Neighborhood Hits	1074	Shared Neighborhood Hits	47
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 771)	NC score	0.056929 (rank : 778)
Query Neighborhood Hits	537	Target Neighborhood Hits	1057	Shared Neighborhood Hits	47
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NBEAL_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.194489 (rank : 412)
Query Neighborhood Hits	537	Target Neighborhood Hits	200	Shared Neighborhood Hits	143
SwissProt Accessions	Q6ZS30, Q6Y876, Q6ZQY5, Q96Q30	Gene names	NBEAL1, ALS2CR17
Domain Architecture	No domain graphic available
Description	Neurobeachin-like 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein).

NBEA_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.124835 (rank : 497)
Query Neighborhood Hits	537	Target Neighborhood Hits	186	Shared Neighborhood Hits	98
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
θ value	θ > 10 (rank : 774)	NC score	0.124794 (rank : 498)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	100
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

NTRK1_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.063480 (rank : 689)
Query Neighborhood Hits	537	Target Neighborhood Hits	1023	Shared Neighborhood Hits	47
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.058496 (rank : 768)
Query Neighborhood Hits	537	Target Neighborhood Hits	1081	Shared Neighborhood Hits	47
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.058494 (rank : 769)
Query Neighborhood Hits	537	Target Neighborhood Hits	1088	Shared Neighborhood Hits	47
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.060621 (rank : 742)
Query Neighborhood Hits	537	Target Neighborhood Hits	1115	Shared Neighborhood Hits	45
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NUP43_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.283394 (rank : 341)
Query Neighborhood Hits	537	Target Neighborhood Hits	198	Shared Neighborhood Hits	152
SwissProt Accessions	Q8NFH3, Q9H8S0	Gene names	NUP43
Domain Architecture
Description	Nucleoporin Nup43 (p42).

NUP43_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.286637 (rank : 339)
Query Neighborhood Hits	537	Target Neighborhood Hits	193	Shared Neighborhood Hits	148
SwissProt Accessions	P59235	Gene names	Nup43
Domain Architecture
Description	Nucleoporin Nup43.

P55G_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.119318 (rank : 516)
Query Neighborhood Hits	537	Target Neighborhood Hits	451	Shared Neighborhood Hits	78
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 782)	NC score	0.116360 (rank : 522)
Query Neighborhood Hits	537	Target Neighborhood Hits	401	Shared Neighborhood Hits	76
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.124380 (rank : 501)
Query Neighborhood Hits	537	Target Neighborhood Hits	543	Shared Neighborhood Hits	100
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 784)	NC score	0.123974 (rank : 504)
Query Neighborhood Hits	537	Target Neighborhood Hits	519	Shared Neighborhood Hits	101
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PGFRA_HUMAN
θ value	θ > 10 (rank : 785)	NC score	0.062460 (rank : 706)
Query Neighborhood Hits	537	Target Neighborhood Hits	980	Shared Neighborhood Hits	48
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 786)	NC score	0.062793 (rank : 699)
Query Neighborhood Hits	537	Target Neighborhood Hits	975	Shared Neighborhood Hits	48
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 787)	NC score	0.062212 (rank : 711)
Query Neighborhood Hits	537	Target Neighborhood Hits	962	Shared Neighborhood Hits	47
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 788)	NC score	0.062387 (rank : 708)
Query Neighborhood Hits	537	Target Neighborhood Hits	960	Shared Neighborhood Hits	49
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PI3R4_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.132899 (rank : 480)
Query Neighborhood Hits	537	Target Neighborhood Hits	534	Shared Neighborhood Hits	129
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.120244 (rank : 514)
Query Neighborhood Hits	537	Target Neighborhood Hits	535	Shared Neighborhood Hits	126
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PKHG1_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.111185 (rank : 529)
Query Neighborhood Hits	537	Target Neighborhood Hits	174	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PPIP2_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.066376 (rank : 655)
Query Neighborhood Hits	537	Target Neighborhood Hits	254	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 793)	NC score	0.061700 (rank : 724)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	29
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PPWD1_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.118563 (rank : 518)
Query Neighborhood Hits	537	Target Neighborhood Hits	136	Shared Neighborhood Hits	95
SwissProt Accessions	Q96BP3, Q15002, Q7KZ89	Gene names	PPWD1, KIAA0073
Domain Architecture	No domain graphic available
Description	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).

PPWD1_MOUSE
θ value	θ > 10 (rank : 795)	NC score	0.113565 (rank : 526)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	94
SwissProt Accessions	Q8CEC6	Gene names	Ppwd1
Domain Architecture	No domain graphic available
Description	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).

PREB_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.256784 (rank : 355)
Query Neighborhood Hits	537	Target Neighborhood Hits	163	Shared Neighborhood Hits	134
SwissProt Accessions	Q9HCU5, Q9UH94	Gene names	PREB, SEC12
Domain Architecture
Description	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12).

PREB_MOUSE
θ value	θ > 10 (rank : 797)	NC score	0.249644 (rank : 363)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	129
SwissProt Accessions	Q9WUQ2, Q9QZ99	Gene names	Preb, Sec12
Domain Architecture
Description	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12).

PREX1_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.104516 (rank : 539)
Query Neighborhood Hits	537	Target Neighborhood Hits	177	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTK7_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.054453 (rank : 812)
Query Neighborhood Hits	537	Target Neighborhood Hits	1103	Shared Neighborhood Hits	50
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PTN11_HUMAN
θ value	θ > 10 (rank : 800)	NC score	0.075160 (rank : 608)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 801)	NC score	0.075172 (rank : 607)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 802)	NC score	0.061971 (rank : 714)
Query Neighborhood Hits	537	Target Neighborhood Hits	234	Shared Neighborhood Hits	60
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 803)	NC score	0.063287 (rank : 692)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RAF1_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.056198 (rank : 781)
Query Neighborhood Hits	537	Target Neighborhood Hits	886	Shared Neighborhood Hits	56
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 805)	NC score	0.055757 (rank : 788)
Query Neighborhood Hits	537	Target Neighborhood Hits	886	Shared Neighborhood Hits	56
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RASA1_HUMAN
θ value	θ > 10 (rank : 806)	NC score	0.137935 (rank : 473)
Query Neighborhood Hits	537	Target Neighborhood Hits	258	Shared Neighborhood Hits	79
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RET_HUMAN
θ value	θ > 10 (rank : 807)	NC score	0.061862 (rank : 717)
Query Neighborhood Hits	537	Target Neighborhood Hits	873	Shared Neighborhood Hits	48
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 808)	NC score	0.061450 (rank : 727)
Query Neighborhood Hits	537	Target Neighborhood Hits	884	Shared Neighborhood Hits	47
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RGNEF_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.066200 (rank : 658)
Query Neighborhood Hits	537	Target Neighborhood Hits	641	Shared Neighborhood Hits	59
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG09_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.062825 (rank : 698)
Query Neighborhood Hits	537	Target Neighborhood Hits	186	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG26_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.155516 (rank : 451)
Query Neighborhood Hits	537	Target Neighborhood Hits	281	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIPK1_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.051045 (rank : 843)
Query Neighborhood Hits	537	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RON_HUMAN
θ value	θ > 10 (rank : 813)	NC score	0.062771 (rank : 700)
Query Neighborhood Hits	537	Target Neighborhood Hits	842	Shared Neighborhood Hits	45
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 814)	NC score	0.063768 (rank : 687)
Query Neighborhood Hits	537	Target Neighborhood Hits	836	Shared Neighborhood Hits	45
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 815)	NC score	0.060315 (rank : 749)
Query Neighborhood Hits	537	Target Neighborhood Hits	1018	Shared Neighborhood Hits	49
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 816)	NC score	0.060444 (rank : 745)
Query Neighborhood Hits	537	Target Neighborhood Hits	1025	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 817)	NC score	0.061783 (rank : 720)
Query Neighborhood Hits	537	Target Neighborhood Hits	1014	Shared Neighborhood Hits	48
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 818)	NC score	0.063507 (rank : 688)
Query Neighborhood Hits	537	Target Neighborhood Hits	1000	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.068568 (rank : 644)
Query Neighborhood Hits	537	Target Neighborhood Hits	907	Shared Neighborhood Hits	47
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RPTOR_HUMAN
θ value	θ > 10 (rank : 820)	NC score	0.165013 (rank : 445)
Query Neighborhood Hits	537	Target Neighborhood Hits	121	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

RPTOR_MOUSE
θ value	θ > 10 (rank : 821)	NC score	0.153589 (rank : 456)
Query Neighborhood Hits	537	Target Neighborhood Hits	129	Shared Neighborhood Hits	84
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

RUSC2_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.075014 (rank : 610)
Query Neighborhood Hits	537	Target Neighborhood Hits	305	Shared Neighborhood Hits	70
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RYK_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.070693 (rank : 630)
Query Neighborhood Hits	537	Target Neighborhood Hits	701	Shared Neighborhood Hits	42
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 824)	NC score	0.069867 (rank : 637)
Query Neighborhood Hits	537	Target Neighborhood Hits	715	Shared Neighborhood Hits	42
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SASH1_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.050949 (rank : 846)
Query Neighborhood Hits	537	Target Neighborhood Hits	292	Shared Neighborhood Hits	65
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SCAP_HUMAN
θ value	θ > 10 (rank : 826)	NC score	0.391564 (rank : 239)
Query Neighborhood Hits	537	Target Neighborhood Hits	368	Shared Neighborhood Hits	175
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

SEC13_HUMAN
θ value	θ > 10 (rank : 827)	NC score	0.393076 (rank : 236)
Query Neighborhood Hits	537	Target Neighborhood Hits	199	Shared Neighborhood Hits	164
SwissProt Accessions	P55735, Q9BRM6, Q9BUG7	Gene names	SEC13L1, SEC13R
Domain Architecture	No domain graphic available
Description	SEC13-related protein (SEC13-like protein 1).

SEC13_MOUSE
θ value	θ > 10 (rank : 828)	NC score	0.398522 (rank : 232)
Query Neighborhood Hits	537	Target Neighborhood Hits	195	Shared Neighborhood Hits	162
SwissProt Accessions	Q9D1M0, Q99M12, Q9D712	Gene names	Sec13l1
Domain Architecture	No domain graphic available
Description	SEC13-related protein (SEC13-like protein 1).

SEH1L_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.330053 (rank : 309)
Query Neighborhood Hits	537	Target Neighborhood Hits	145	Shared Neighborhood Hits	121
SwissProt Accessions	Q96EE3, Q8NFU6, Q96MH3, Q9C069	Gene names	SEH1L, SEC13L, SEH1
Domain Architecture
Description	Nucleoporin SEH1-like (SEC13-like protein).

SH21A_HUMAN
θ value	θ > 10 (rank : 830)	NC score	0.095914 (rank : 555)
Query Neighborhood Hits	537	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 831)	NC score	0.099422 (rank : 551)
Query Neighborhood Hits	537	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 832)	NC score	0.116822 (rank : 521)
Query Neighborhood Hits	537	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 833)	NC score	0.127396 (rank : 493)
Query Neighborhood Hits	537	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.060713 (rank : 741)
Query Neighborhood Hits	537	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 835)	NC score	0.067429 (rank : 649)
Query Neighborhood Hits	537	Target Neighborhood Hits	179	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH24A_HUMAN
θ value	θ > 10 (rank : 836)	NC score	0.076381 (rank : 600)
Query Neighborhood Hits	537	Target Neighborhood Hits	455	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 837)	NC score	0.053038 (rank : 823)
Query Neighborhood Hits	537	Target Neighborhood Hits	326	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 838)	NC score	0.061199 (rank : 732)
Query Neighborhood Hits	537	Target Neighborhood Hits	188	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 839)	NC score	0.064181 (rank : 679)
Query Neighborhood Hits	537	Target Neighborhood Hits	174	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHAN1_HUMAN
θ value	θ > 10 (rank : 840)	NC score	0.104752 (rank : 537)
Query Neighborhood Hits	537	Target Neighborhood Hits	1041	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHB_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.097793 (rank : 552)
Query Neighborhood Hits	537	Target Neighborhood Hits	141	Shared Neighborhood Hits	56
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.099660 (rank : 549)
Query Neighborhood Hits	537	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.094320 (rank : 560)
Query Neighborhood Hits	537	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 844)	NC score	0.095130 (rank : 556)
Query Neighborhood Hits	537	Target Neighborhood Hits	180	Shared Neighborhood Hits	59
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.093285 (rank : 562)
Query Neighborhood Hits	537	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 846)	NC score	0.090766 (rank : 567)
Query Neighborhood Hits	537	Target Neighborhood Hits	144	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.088537 (rank : 570)
Query Neighborhood Hits	537	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 848)	NC score	0.094692 (rank : 558)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 849)	NC score	0.093131 (rank : 563)
Query Neighborhood Hits	537	Target Neighborhood Hits	204	Shared Neighborhood Hits	56
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 850)	NC score	0.094213 (rank : 561)
Query Neighborhood Hits	537	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 851)	NC score	0.101511 (rank : 542)
Query Neighborhood Hits	537	Target Neighborhood Hits	164	Shared Neighborhood Hits	54
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 852)	NC score	0.104832 (rank : 536)
Query Neighborhood Hits	537	Target Neighborhood Hits	169	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.132308 (rank : 482)
Query Neighborhood Hits	537	Target Neighborhood Hits	96	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.136250 (rank : 475)
Query Neighborhood Hits	537	Target Neighborhood Hits	101	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.115952 (rank : 523)
Query Neighborhood Hits	537	Target Neighborhood Hits	86	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.122033 (rank : 510)
Query Neighborhood Hits	537	Target Neighborhood Hits	88	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.201686 (rank : 406)
Query Neighborhood Hits	537	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.199904 (rank : 407)
Query Neighborhood Hits	537	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLY_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.070562 (rank : 631)
Query Neighborhood Hits	537	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 860)	NC score	0.084035 (rank : 578)
Query Neighborhood Hits	537	Target Neighborhood Hits	108	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX9_MOUSE
θ value	θ > 10 (rank : 861)	NC score	0.110951 (rank : 530)
Query Neighborhood Hits	537	Target Neighborhood Hits	141	Shared Neighborhood Hits	87
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SOCS6_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.058133 (rank : 772)
Query Neighborhood Hits	537	Target Neighborhood Hits	126	Shared Neighborhood Hits	42
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.057870 (rank : 775)
Query Neighborhood Hits	537	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 864)	NC score	0.073641 (rank : 615)
Query Neighborhood Hits	537	Target Neighborhood Hits	154	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPN90_HUMAN
θ value	θ > 10 (rank : 865)	NC score	0.163672 (rank : 448)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 866)	NC score	0.142595 (rank : 466)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRMS_HUMAN
θ value	θ > 10 (rank : 867)	NC score	0.101332 (rank : 543)
Query Neighborhood Hits	537	Target Neighborhood Hits	946	Shared Neighborhood Hits	96
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

STB5L_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.078344 (rank : 594)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y2K9, Q4G1B4, Q6PIC3	Gene names	STXBP5L, KIAA1006, LLGL4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5-like (Tomosyn-2) (Lethal(2) giant larvae protein homolog 4).

STB5L_MOUSE
θ value	θ > 10 (rank : 869)	NC score	0.076555 (rank : 599)
Query Neighborhood Hits	537	Target Neighborhood Hits	138	Shared Neighborhood Hits	91
SwissProt Accessions	Q5DQR4, Q3TSM3, Q3UVG2, Q5DQR1, Q5DQR2, Q5DQR3, Q8BS52	Gene names	Stxbp5l, Llgl4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5-like (Tomosyn-2) (Lethal(2) giant larvae protein homolog 4).

STS2_HUMAN
θ value	θ > 10 (rank : 870)	NC score	0.122518 (rank : 507)
Query Neighborhood Hits	537	Target Neighborhood Hits	108	Shared Neighborhood Hits	81
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

STXB5_HUMAN
θ value	θ > 10 (rank : 871)	NC score	0.080440 (rank : 588)
Query Neighborhood Hits	537	Target Neighborhood Hits	167	Shared Neighborhood Hits	105
SwissProt Accessions	Q5T5C0, Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9	Gene names	STXBP5, LLGL3
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5 (Tomosyn-1) (Lethal(2) giant larvae protein homolog 3).

STXB5_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.073147 (rank : 618)
Query Neighborhood Hits	537	Target Neighborhood Hits	161	Shared Neighborhood Hits	100
SwissProt Accessions	Q8K400, Q80TM5, Q8K401, Q9D2F3	Gene names	Stxbp5, Kiaa4253, Llgl3
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5 (Tomosyn-1) (Lethal(2) giant larvae protein homolog 3).

STYK1_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.069173 (rank : 642)
Query Neighborhood Hits	537	Target Neighborhood Hits	786	Shared Neighborhood Hits	45
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.069406 (rank : 640)
Query Neighborhood Hits	537	Target Neighborhood Hits	779	Shared Neighborhood Hits	47
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TEX14_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.071453 (rank : 626)
Query Neighborhood Hits	537	Target Neighborhood Hits	1103	Shared Neighborhood Hits	76
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 876)	NC score	0.072493 (rank : 621)
Query Neighborhood Hits	537	Target Neighborhood Hits	1333	Shared Neighborhood Hits	86
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TF3C2_HUMAN
θ value	θ > 10 (rank : 877)	NC score	0.078606 (rank : 593)
Query Neighborhood Hits	537	Target Neighborhood Hits	168	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

TF3C2_MOUSE
θ value	θ > 10 (rank : 878)	NC score	0.088707 (rank : 569)
Query Neighborhood Hits	537	Target Neighborhood Hits	165	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

TIAM1_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.099878 (rank : 545)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	32
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 880)	NC score	0.102866 (rank : 540)
Query Neighborhood Hits	537	Target Neighborhood Hits	205	Shared Neighborhood Hits	31
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIE1_HUMAN
θ value	θ > 10 (rank : 881)	NC score	0.055528 (rank : 793)
Query Neighborhood Hits	537	Target Neighborhood Hits	1241	Shared Neighborhood Hits	48
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 882)	NC score	0.055279 (rank : 801)
Query Neighborhood Hits	537	Target Neighborhood Hits	1266	Shared Neighborhood Hits	48
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 883)	NC score	0.055512 (rank : 796)
Query Neighborhood Hits	537	Target Neighborhood Hits	1192	Shared Neighborhood Hits	48
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 884)	NC score	0.055372 (rank : 799)
Query Neighborhood Hits	537	Target Neighborhood Hits	1204	Shared Neighborhood Hits	48
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TLE2_HUMAN
θ value	θ > 10 (rank : 885)	NC score	0.353847 (rank : 290)
Query Neighborhood Hits	537	Target Neighborhood Hits	321	Shared Neighborhood Hits	206
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

TLE2_MOUSE
θ value	θ > 10 (rank : 886)	NC score	0.352364 (rank : 292)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	205
SwissProt Accessions	Q9WVB2	Gene names	Tle2, Grg2
Domain Architecture
Description	Transducin-like enhancer protein 2.

TLE6_HUMAN
θ value	θ > 10 (rank : 887)	NC score	0.145975 (rank : 462)
Query Neighborhood Hits	537	Target Neighborhood Hits	120	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H808	Gene names	TLE6
Domain Architecture	No domain graphic available
Description	Transducin-like enhancer protein 6.

TLE6_MOUSE
θ value	θ > 10 (rank : 888)	NC score	0.247068 (rank : 366)
Query Neighborhood Hits	537	Target Neighborhood Hits	178	Shared Neighborhood Hits	125
SwissProt Accessions	Q9WVB3	Gene names	Tle6, Grg6
Domain Architecture
Description	Transducin-like enhancer protein 6 (Groucho-related protein 6).

TNI3K_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.050859 (rank : 847)
Query Neighborhood Hits	537	Target Neighborhood Hits	1084	Shared Neighborhood Hits	60
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 890)	NC score	0.051164 (rank : 841)
Query Neighborhood Hits	537	Target Neighborhood Hits	1079	Shared Neighborhood Hits	60
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNK1_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.067959 (rank : 645)
Query Neighborhood Hits	537	Target Neighborhood Hits	815	Shared Neighborhood Hits	51
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 892)	NC score	0.067553 (rank : 647)
Query Neighborhood Hits	537	Target Neighborhood Hits	806	Shared Neighborhood Hits	51
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TR95_MOUSE
θ value	θ > 10 (rank : 893)	NC score	0.071305 (rank : 628)
Query Neighborhood Hits	537	Target Neighborhood Hits	95	Shared Neighborhood Hits	72
SwissProt Accessions	Q6PGF3	Gene names	Thrap5
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein complex 95 kDa component (Trap95) (Thyroid hormone receptor-associated protein 5) (Vitamin D3 receptor-interacting protein complex component DRIP92).

TRAF7_HUMAN
θ value	θ > 10 (rank : 894)	NC score	0.450712 (rank : 166)
Query Neighborhood Hits	537	Target Neighborhood Hits	482	Shared Neighborhood Hits	213
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

TRAF7_MOUSE
θ value	θ > 10 (rank : 895)	NC score	0.453180 (rank : 164)
Query Neighborhood Hits	537	Target Neighborhood Hits	470	Shared Neighborhood Hits	212
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TSCC1_MOUSE
θ value	θ > 10 (rank : 896)	NC score	0.254416 (rank : 357)
Query Neighborhood Hits	537	Target Neighborhood Hits	160	Shared Neighborhood Hits	117
SwissProt Accessions	Q8K0G5	Gene names	Tssc1
Domain Architecture	No domain graphic available
Description	Protein TSSC1.

TSSC1_HUMAN
θ value	θ > 10 (rank : 897)	NC score	0.250700 (rank : 360)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	121
SwissProt Accessions	Q53HC9, O43179, Q53S19, Q53SG2	Gene names	TSSC1
Domain Architecture	No domain graphic available
Description	Protein TSSC1 (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) (Tumor-suppressing STF cDNA 1 protein).

TULP4_HUMAN
θ value	θ > 10 (rank : 898)	NC score	0.067537 (rank : 648)
Query Neighborhood Hits	537	Target Neighborhood Hits	426	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

TULP4_MOUSE
θ value	θ > 10 (rank : 899)	NC score	0.072688 (rank : 620)
Query Neighborhood Hits	537	Target Neighborhood Hits	247	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JIL5, Q8CA75, Q922C2	Gene names	Tulp4, Tusp
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

TYK2_HUMAN
θ value	θ > 10 (rank : 900)	NC score	0.054158 (rank : 816)
Query Neighborhood Hits	537	Target Neighborhood Hits	841	Shared Neighborhood Hits	47
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 901)	NC score	0.054668 (rank : 811)
Query Neighborhood Hits	537	Target Neighborhood Hits	850	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.059047 (rank : 761)
Query Neighborhood Hits	537	Target Neighborhood Hits	995	Shared Neighborhood Hits	44
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 903)	NC score	0.059313 (rank : 759)
Query Neighborhood Hits	537	Target Neighborhood Hits	1007	Shared Neighborhood Hits	45
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 904)	NC score	0.060413 (rank : 746)
Query Neighborhood Hits	537	Target Neighborhood Hits	981	Shared Neighborhood Hits	50
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 905)	NC score	0.060051 (rank : 751)
Query Neighborhood Hits	537	Target Neighborhood Hits	988	Shared Neighborhood Hits	50
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

UTP18_HUMAN
θ value	θ > 10 (rank : 906)	NC score	0.283516 (rank : 340)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y5J1, Q9H4N6	Gene names	UTP18, WDR50
Domain Architecture
Description	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat protein 50).

VGFR1_HUMAN
θ value	θ > 10 (rank : 907)	NC score	0.052271 (rank : 830)
Query Neighborhood Hits	537	Target Neighborhood Hits	1109	Shared Neighborhood Hits	48
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 908)	NC score	0.051715 (rank : 833)
Query Neighborhood Hits	537	Target Neighborhood Hits	1118	Shared Neighborhood Hits	47
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 909)	NC score	0.053242 (rank : 822)
Query Neighborhood Hits	537	Target Neighborhood Hits	1103	Shared Neighborhood Hits	49
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.053458 (rank : 821)
Query Neighborhood Hits	537	Target Neighborhood Hits	1089	Shared Neighborhood Hits	47
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 911)	NC score	0.055928 (rank : 784)
Query Neighborhood Hits	537	Target Neighborhood Hits	1037	Shared Neighborhood Hits	47
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 912)	NC score	0.055628 (rank : 792)
Query Neighborhood Hits	537	Target Neighborhood Hits	1056	Shared Neighborhood Hits	48
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

WD21A_HUMAN
θ value	θ > 10 (rank : 913)	NC score	0.223789 (rank : 387)
Query Neighborhood Hits	537	Target Neighborhood Hits	136	Shared Neighborhood Hits	113
SwissProt Accessions	Q8WV16, Q86U31, Q96K22, Q9Y4P5	Gene names	WDR21A, WDR21
Domain Architecture
Description	WD repeat protein 21A.

WD21C_HUMAN
θ value	θ > 10 (rank : 914)	NC score	0.282041 (rank : 343)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	124
SwissProt Accessions	Q8NA75	Gene names	WDR21C
Domain Architecture	No domain graphic available
Description	WD repeat protein 21C.

WDFY3_MOUSE
θ value	θ > 10 (rank : 915)	NC score	0.222652 (rank : 388)
Query Neighborhood Hits	537	Target Neighborhood Hits	332	Shared Neighborhood Hits	168
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDR18_MOUSE
θ value	θ > 10 (rank : 916)	NC score	0.469922 (rank : 147)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	191
SwissProt Accessions	Q4VBE8	Gene names	Wdr18
Domain Architecture	No domain graphic available
Description	WD repeat protein 18.

WDR19_HUMAN
θ value	θ > 10 (rank : 917)	NC score	0.062494 (rank : 705)
Query Neighborhood Hits	537	Target Neighborhood Hits	88	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NEZ3, Q8N5B4, Q9H5S0, Q9HCD4	Gene names	WDR19, KIAA1638
Domain Architecture	No domain graphic available
Description	WD repeat protein 19.

WDR19_MOUSE
θ value	θ > 10 (rank : 918)	NC score	0.060108 (rank : 750)
Query Neighborhood Hits	537	Target Neighborhood Hits	83	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UGF1, Q6ZPK8, Q80VQ6, Q8C794, Q8K3R5	Gene names	Wdr19, Kiaa1638
Domain Architecture	No domain graphic available
Description	WD repeat protein 19.

WDR34_HUMAN
θ value	θ > 10 (rank : 919)	NC score	0.104719 (rank : 538)
Query Neighborhood Hits	537	Target Neighborhood Hits	100	Shared Neighborhood Hits	70
SwissProt Accessions	Q96EX3, Q5VXV4, Q9BV46	Gene names	WDR34
Domain Architecture
Description	WD repeat protein 34.

WDR35_HUMAN
θ value	θ > 10 (rank : 920)	NC score	0.117978 (rank : 519)
Query Neighborhood Hits	537	Target Neighborhood Hits	132	Shared Neighborhood Hits	96
SwissProt Accessions	Q9P2L0, Q8NE11	Gene names	WDR35, KIAA1336
Domain Architecture
Description	WD repeat protein 35.

WDR35_MOUSE
θ value	θ > 10 (rank : 921)	NC score	0.106187 (rank : 534)
Query Neighborhood Hits	537	Target Neighborhood Hits	126	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BND3, Q8CDL4	Gene names	Wdr35
Domain Architecture
Description	WD repeat protein 35.

WDR41_HUMAN
θ value	θ > 10 (rank : 922)	NC score	0.344078 (rank : 300)
Query Neighborhood Hits	537	Target Neighborhood Hits	208	Shared Neighborhood Hits	168
SwissProt Accessions	Q9HAD4, Q7Z792, Q8IWG3, Q8IXA9, Q8NDA7, Q9NV62	Gene names	WDR41
Domain Architecture	No domain graphic available
Description	WD repeat protein 41.

WDR41_MOUSE
θ value	θ > 10 (rank : 923)	NC score	0.370681 (rank : 263)
Query Neighborhood Hits	537	Target Neighborhood Hits	209	Shared Neighborhood Hits	165
SwissProt Accessions	Q3UDP0, Q8C4F1, Q8C8K5	Gene names	Wdr41
Domain Architecture	No domain graphic available
Description	WD repeat protein 41.

WDR43_HUMAN
θ value	θ > 10 (rank : 924)	NC score	0.437570 (rank : 185)
Query Neighborhood Hits	537	Target Neighborhood Hits	269	Shared Neighborhood Hits	162
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

WDR46_HUMAN
θ value	θ > 10 (rank : 925)	NC score	0.184769 (rank : 418)
Query Neighborhood Hits	537	Target Neighborhood Hits	147	Shared Neighborhood Hits	100
SwissProt Accessions	O15213, Q5STK5	Gene names	WDR46, BING4, C6orf11
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

WDR46_MOUSE
θ value	θ > 10 (rank : 926)	NC score	0.164074 (rank : 447)
Query Neighborhood Hits	537	Target Neighborhood Hits	243	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

WDR49_HUMAN
θ value	θ > 10 (rank : 927)	NC score	0.427454 (rank : 198)
Query Neighborhood Hits	537	Target Neighborhood Hits	214	Shared Neighborhood Hits	167
SwissProt Accessions	Q8IV35, Q8N297	Gene names	WDR49
Domain Architecture	No domain graphic available
Description	WD repeat protein 49.

WDR53_MOUSE
θ value	θ > 10 (rank : 928)	NC score	0.441758 (rank : 175)
Query Neighborhood Hits	537	Target Neighborhood Hits	254	Shared Neighborhood Hits	201
SwissProt Accessions	Q9DB94	Gene names	Wdr53
Domain Architecture	No domain graphic available
Description	WD repeat protein 53.

WDR54_HUMAN
θ value	θ > 10 (rank : 929)	NC score	0.080084 (rank : 589)
Query Neighborhood Hits	537	Target Neighborhood Hits	70	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H977, Q53H85, Q86V45	Gene names	WDR54
Domain Architecture	No domain graphic available
Description	WD repeat protein 54.

WDR54_MOUSE
θ value	θ > 10 (rank : 930)	NC score	0.137415 (rank : 474)
Query Neighborhood Hits	537	Target Neighborhood Hits	96	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R0D8, Q3U4A4	Gene names	Wdr54, D3Mm3e
Domain Architecture	No domain graphic available
Description	WD repeat protein 54.

WDR55_HUMAN
θ value	θ > 10 (rank : 931)	NC score	0.450096 (rank : 167)
Query Neighborhood Hits	537	Target Neighborhood Hits	231	Shared Neighborhood Hits	184
SwissProt Accessions	Q9H6Y2	Gene names	WDR55
Domain Architecture	No domain graphic available
Description	WD repeat protein 55.

WDR55_MOUSE
θ value	θ > 10 (rank : 932)	NC score	0.439050 (rank : 181)
Query Neighborhood Hits	537	Target Neighborhood Hits	236	Shared Neighborhood Hits	181
SwissProt Accessions	Q9CX97	Gene names	Wdr55
Domain Architecture	No domain graphic available
Description	WD repeat protein 55.

WDR67_HUMAN
θ value	θ > 10 (rank : 933)	NC score	0.183121 (rank : 419)
Query Neighborhood Hits	537	Target Neighborhood Hits	782	Shared Neighborhood Hits	147
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

WDR67_MOUSE
θ value	θ > 10 (rank : 934)	NC score	0.212695 (rank : 397)
Query Neighborhood Hits	537	Target Neighborhood Hits	476	Shared Neighborhood Hits	129
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

WDR68_HUMAN
θ value	θ > 10 (rank : 935)	NC score	0.179948 (rank : 426)
Query Neighborhood Hits	537	Target Neighborhood Hits	121	Shared Neighborhood Hits	102
SwissProt Accessions	P61962, O15491, Q9DAE4	Gene names	WDR68, HAN11
Domain Architecture
Description	WD repeat protein 68 (WD repeat protein An11 homolog).

WDR68_MOUSE
θ value	θ > 10 (rank : 936)	NC score	0.179948 (rank : 427)
Query Neighborhood Hits	537	Target Neighborhood Hits	121	Shared Neighborhood Hits	102
SwissProt Accessions	P61963, O15491, Q3TMV9, Q9DAE4	Gene names	Wdr68, Han11
Domain Architecture
Description	WD repeat protein 68 (WD repeat protein An11 homolog).

WDR72_HUMAN
θ value	θ > 10 (rank : 937)	NC score	0.242973 (rank : 370)
Query Neighborhood Hits	537	Target Neighborhood Hits	167	Shared Neighborhood Hits	125
SwissProt Accessions	Q3MJ13, Q7Z3I3, Q8N8X2	Gene names	WDR72
Domain Architecture	No domain graphic available
Description	WD repeat protein 72.

WDR74_HUMAN
θ value	θ > 10 (rank : 938)	NC score	0.137958 (rank : 472)
Query Neighborhood Hits	537	Target Neighborhood Hits	94	Shared Neighborhood Hits	70
SwissProt Accessions	Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2	Gene names	WDR74, NSA1
Domain Architecture	No domain graphic available
Description	WD repeat protein 74 (NOP seven-associated protein 1).

WDR74_MOUSE
θ value	θ > 10 (rank : 939)	NC score	0.097273 (rank : 554)
Query Neighborhood Hits	537	Target Neighborhood Hits	70	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCG3	Gene names	Wdr74
Domain Architecture	No domain graphic available
Description	WD repeat protein 74.

WDR75_HUMAN
θ value	θ > 10 (rank : 940)	NC score	0.336728 (rank : 305)
Query Neighborhood Hits	537	Target Neighborhood Hits	193	Shared Neighborhood Hits	143
SwissProt Accessions	Q8IWA0, Q96J10, Q9H8U8, Q9H9U5, Q9H9V8, Q9UIX2	Gene names	WDR75
Domain Architecture	No domain graphic available
Description	WD repeat protein 75.

WDR76_HUMAN
θ value	θ > 10 (rank : 941)	NC score	0.072805 (rank : 619)
Query Neighborhood Hits	537	Target Neighborhood Hits	73	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H967	Gene names	WDR76
Domain Architecture	No domain graphic available
Description	WD repeat protein 76.

WDR81_HUMAN
θ value	θ > 10 (rank : 942)	NC score	0.256782 (rank : 356)
Query Neighborhood Hits	537	Target Neighborhood Hits	205	Shared Neighborhood Hits	140
SwissProt Accessions	Q562E7, Q24JP6, Q8N277, Q8N3F3	Gene names	WDR81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

WDR81_MOUSE
θ value	θ > 10 (rank : 943)	NC score	0.281920 (rank : 344)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	156
SwissProt Accessions	Q5ND34, Q3TA90, Q3TUS9, Q6KAR1	Gene names	Wdr81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

WDR85_HUMAN
θ value	θ > 10 (rank : 944)	NC score	0.189147 (rank : 416)
Query Neighborhood Hits	537	Target Neighborhood Hits	134	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BTV6, Q96AB7	Gene names	WDR85, C9orf112
Domain Architecture	No domain graphic available
Description	WD repeat protein 85.

WDR85_MOUSE
θ value	θ > 10 (rank : 945)	NC score	0.128531 (rank : 488)
Query Neighborhood Hits	537	Target Neighborhood Hits	108	Shared Neighborhood Hits	76
SwissProt Accessions	Q9CYU6, Q5RJV7, Q8BIT9	Gene names	Wdr85
Domain Architecture	No domain graphic available
Description	WD repeat protein 85.

WDR8_HUMAN
θ value	θ > 10 (rank : 946)	NC score	0.120229 (rank : 515)
Query Neighborhood Hits	537	Target Neighborhood Hits	69	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P2S5, Q5T0D6, Q9BUH7, Q9NTK7, Q9NX56	Gene names	WDR8
Domain Architecture
Description	WD repeat protein 8.

WDR8_MOUSE
θ value	θ > 10 (rank : 947)	NC score	0.111562 (rank : 528)
Query Neighborhood Hits	537	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JM98	Gene names	Wdr8, Dd57
Domain Architecture
Description	WD repeat protein 8.

WIPI1_HUMAN
θ value	θ > 10 (rank : 948)	NC score	0.061868 (rank : 716)
Query Neighborhood Hits	537	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q5MNZ9, Q8IXM5, Q9NWF8	Gene names	WIPI1, WIPI49
Domain Architecture	No domain graphic available
Description	WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa) (Atg18 protein homolog).

WIPI1_MOUSE
θ value	θ > 10 (rank : 949)	NC score	0.069525 (rank : 638)
Query Neighborhood Hits	537	Target Neighborhood Hits	67	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R3E3, Q8BGE1, Q8R1A9, Q8R1C7	Gene names	Wipi1, D11Ertd498e
Domain Architecture	No domain graphic available
Description	WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa).

ZAP70_HUMAN
θ value	θ > 10 (rank : 950)	NC score	0.079929 (rank : 590)
Query Neighborhood Hits	537	Target Neighborhood Hits	893	Shared Neighborhood Hits	73
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 951)	NC score	0.080557 (rank : 587)
Query Neighborhood Hits	537	Target Neighborhood Hits	905	Shared Neighborhood Hits	73
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

AHI1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	537	Target Neighborhood Hits	537	Shared Neighborhood Hits	537
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.976895 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	537	Target Neighborhood Hits	496	Shared Neighborhood Hits	432
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

WDR5_HUMAN
NC score	0.643694 (rank : 3)	θ value	1.80048e-24 (rank : 3)
Query Neighborhood Hits	537	Target Neighborhood Hits	341	Shared Neighborhood Hits	226
SwissProt Accessions	P61964, Q91VA5, Q9NWX7, Q9UGP9	Gene names	WDR5, BIG3
Domain Architecture
Description	WD repeat protein 5 (BMP2-induced 3-kb gene protein).

WDR5_MOUSE
NC score	0.643694 (rank : 4)	θ value	1.80048e-24 (rank : 4)
Query Neighborhood Hits	537	Target Neighborhood Hits	341	Shared Neighborhood Hits	226
SwissProt Accessions	P61965, Q91VA5, Q922C9, Q9NWX7, Q9UGP9	Gene names	Wdr5, Big, Big3
Domain Architecture
Description	WD repeat protein 5 (BMP2-induced 3-kb gene protein) (WD repeat protein BIG-3).

WDR57_HUMAN
NC score	0.623127 (rank : 5)	θ value	5.8054e-15 (rank : 5)
Query Neighborhood Hits	537	Target Neighborhood Hits	322	Shared Neighborhood Hits	227
SwissProt Accessions	Q96DI7, O75938, O95320	Gene names	WDR57, PRP8BP, SFP38
Domain Architecture	No domain graphic available
Description	WD repeat protein 57 (Prp8-binding protein) (hPRP8BP) (U5 snRNP- specific 40 kDa protein) (38 kDa-splicing factor).

MORG1_MOUSE
NC score	0.622915 (rank : 6)	θ value	1.47974e-10 (rank : 17)
Query Neighborhood Hits	537	Target Neighborhood Hits	281	Shared Neighborhood Hits	214
SwissProt Accessions	Q9DAJ4, Q505C2, Q8VEB7, Q99JX9, Q9D235	Gene names	Morg1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase organizer 1 (MAPK organizer 1).

WDR57_MOUSE
NC score	0.622024 (rank : 7)	θ value	2.20605e-14 (rank : 6)
Query Neighborhood Hits	537	Target Neighborhood Hits	323	Shared Neighborhood Hits	227
SwissProt Accessions	Q6PE01, Q3TEJ3, Q9DCX3	Gene names	Wdr57
Domain Architecture	No domain graphic available
Description	WD repeat protein 57.

MORG1_HUMAN
NC score	0.617261 (rank : 8)	θ value	3.64472e-09 (rank : 25)
Query Neighborhood Hits	537	Target Neighborhood Hits	280	Shared Neighborhood Hits	213
SwissProt Accessions	Q9BRX9, Q53FT6	Gene names	MORG1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase organizer 1 (MAPK organizer 1).

SPG16_HUMAN
NC score	0.613869 (rank : 9)	θ value	1.06045e-08 (rank : 32)
Query Neighborhood Hits	537	Target Neighborhood Hits	361	Shared Neighborhood Hits	227
SwissProt Accessions	Q8N0X2, Q658W1, Q68DB3, Q6I9Z6, Q8N9C7, Q9H601	Gene names	SPAG16, PF20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

SMU1_HUMAN
NC score	0.611238 (rank : 10)	θ value	9.26847e-13 (rank : 8)
Query Neighborhood Hits	537	Target Neighborhood Hits	311	Shared Neighborhood Hits	223
SwissProt Accessions	Q2TAY7, Q9BU59, Q9HA96, Q9NVD1	Gene names	SMU1
Domain Architecture	No domain graphic available
Description	Smu-1 suppressor of mec-8 and unc-52 protein homolog.

SMU1_MOUSE
NC score	0.611238 (rank : 11)	θ value	9.26847e-13 (rank : 9)
Query Neighborhood Hits	537	Target Neighborhood Hits	311	Shared Neighborhood Hits	223
SwissProt Accessions	Q3UKJ7, Q6PFR6, Q8BMY4, Q9D1I8, Q9JJ70	Gene names	Smu1
Domain Architecture	No domain graphic available
Description	Smu-1 suppressor of mec-8 and unc-52 protein homolog.

WDR69_HUMAN
NC score	0.610733 (rank : 12)	θ value	1.47974e-10 (rank : 18)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	223
SwissProt Accessions	Q8N136, Q6ZRY1, Q8N776	Gene names	WDR69
Domain Architecture	No domain graphic available
Description	WD repeat protein 69.

GBLP_HUMAN
NC score	0.607727 (rank : 13)	θ value	8.11959e-09 (rank : 29)
Query Neighborhood Hits	537	Target Neighborhood Hits	316	Shared Neighborhood Hits	224
SwissProt Accessions	P63244, P25388, P99049	Gene names	GNB2L1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 2-like 1 (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Receptor of activated protein kinase C 1) (RACK1) (Receptor for activated C kinase).

GBLP_MOUSE
NC score	0.607727 (rank : 14)	θ value	8.11959e-09 (rank : 30)
Query Neighborhood Hits	537	Target Neighborhood Hits	316	Shared Neighborhood Hits	224
SwissProt Accessions	P68040, P25388, P99049	Gene names	Gnb2l1, Gnb2-rs1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 2-like 1 (Receptor of activated protein kinase C 1) (RACK1) (Receptor for activated C kinase) (p205) (12-3).

WD51B_MOUSE
NC score	0.607700 (rank : 15)	θ value	1.25267e-09 (rank : 22)
Query Neighborhood Hits	537	Target Neighborhood Hits	321	Shared Neighborhood Hits	228
SwissProt Accessions	Q8BHD1	Gene names	Wdr51b
Domain Architecture	No domain graphic available
Description	WD repeat protein 51B.

WD51B_HUMAN
NC score	0.606261 (rank : 16)	θ value	6.64225e-11 (rank : 16)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	228
SwissProt Accessions	Q8TC44	Gene names	WDR51B
Domain Architecture	No domain graphic available
Description	WD repeat protein 51B.

SPG16_MOUSE
NC score	0.604692 (rank : 17)	θ value	8.97725e-08 (rank : 46)
Query Neighborhood Hits	537	Target Neighborhood Hits	377	Shared Neighborhood Hits	229
SwissProt Accessions	Q8K450, Q8C450, Q9CPU8, Q9D522	Gene names	Spag16, Pf20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

WD51A_MOUSE
NC score	0.603641 (rank : 18)	θ value	6.64225e-11 (rank : 15)
Query Neighborhood Hits	537	Target Neighborhood Hits	342	Shared Neighborhood Hits	225
SwissProt Accessions	Q8JZX3, Q9CY09	Gene names	Wdr51a
Domain Architecture	No domain graphic available
Description	WD repeat protein 51A.

WD51A_HUMAN
NC score	0.602672 (rank : 19)	θ value	7.34386e-10 (rank : 20)
Query Neighborhood Hits	537	Target Neighborhood Hits	337	Shared Neighborhood Hits	225
SwissProt Accessions	Q8NBT0, Q2TAK6, Q96IK6, Q9UFJ8	Gene names	WDR51A
Domain Architecture	No domain graphic available
Description	WD repeat protein 51A.

KTNB1_HUMAN
NC score	0.599437 (rank : 20)	θ value	6.64225e-11 (rank : 13)
Query Neighborhood Hits	537	Target Neighborhood Hits	349	Shared Neighborhood Hits	229
SwissProt Accessions	Q9BVA0, O60620	Gene names	KATNB1
Domain Architecture	No domain graphic available
Description	Katanin p80 WD40-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin).

KTNB1_MOUSE
NC score	0.598969 (rank : 21)	θ value	6.64225e-11 (rank : 14)
Query Neighborhood Hits	537	Target Neighborhood Hits	356	Shared Neighborhood Hits	227
SwissProt Accessions	Q8BG40, Q8CD18, Q8R1J0, Q9CWV2	Gene names	Katnb1
Domain Architecture	No domain graphic available
Description	Katanin p80 WD40-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin).

PRP17_MOUSE
NC score	0.598662 (rank : 22)	θ value	9.92553e-07 (rank : 65)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	216
SwissProt Accessions	Q9DC48	Gene names	Cdc40, Prp17
Domain Architecture
Description	Pre-mRNA-splicing factor PRP17 (Cell division cycle 40 homolog).

PRP17_HUMAN
NC score	0.598388 (rank : 23)	θ value	7.59969e-07 (rank : 64)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	217
SwissProt Accessions	O60508, O75471, Q9UPG1	Gene names	CDC40, PRP17
Domain Architecture
Description	Pre-mRNA-splicing factor PRP17 (hPRP17) (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3).

TBL3_HUMAN
NC score	0.597598 (rank : 24)	θ value	2.61198e-07 (rank : 56)
Query Neighborhood Hits	537	Target Neighborhood Hits	286	Shared Neighborhood Hits	212
SwissProt Accessions	Q12788	Gene names	TBL3, SAZD
Domain Architecture
Description	WD repeat protein SAZD (Transducin beta-like 3 protein).

NLE1_HUMAN
NC score	0.597270 (rank : 25)	θ value	1.17247e-07 (rank : 48)
Query Neighborhood Hits	537	Target Neighborhood Hits	334	Shared Neighborhood Hits	227
SwissProt Accessions	Q9NVX2, O60868, Q9BU54	Gene names	NLE1
Domain Architecture
Description	Notchless homolog 1.

NLE1_MOUSE
NC score	0.596982 (rank : 26)	θ value	1.17247e-07 (rank : 49)
Query Neighborhood Hits	537	Target Neighborhood Hits	332	Shared Neighborhood Hits	227
SwissProt Accessions	Q8VEJ4	Gene names	Nle1
Domain Architecture
Description	Notchless homolog 1.

PRP4_HUMAN
NC score	0.595519 (rank : 27)	θ value	6.87365e-08 (rank : 43)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	224
SwissProt Accessions	O43172, O43445, O43864, Q96DG2, Q96IK4	Gene names	PRPF4, PRP4
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) (hPrp4).

PRP4_MOUSE
NC score	0.595410 (rank : 28)	θ value	4.0297e-08 (rank : 40)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	222
SwissProt Accessions	Q9DAW6	Gene names	Prpf4
Domain Architecture	No domain graphic available
Description	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4).

TAF5_HUMAN
NC score	0.593337 (rank : 29)	θ value	2.61198e-07 (rank : 54)
Query Neighborhood Hits	537	Target Neighborhood Hits	352	Shared Neighborhood Hits	228
SwissProt Accessions	Q15542, Q86UZ7, Q9Y4K5	Gene names	TAF5, TAF2D
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

STRAP_HUMAN
NC score	0.591549 (rank : 30)	θ value	1.99992e-07 (rank : 53)
Query Neighborhood Hits	537	Target Neighborhood Hits	272	Shared Neighborhood Hits	214
SwissProt Accessions	Q9Y3F4, Q9UQC8	Gene names	STRAP, MAWD, UNRIP
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein) (WD-40 repeat protein PT-WD) (MAP activator with WD repeats).

TAF5_MOUSE
NC score	0.591468 (rank : 31)	θ value	2.61198e-07 (rank : 55)
Query Neighborhood Hits	537	Target Neighborhood Hits	366	Shared Neighborhood Hits	228
SwissProt Accessions	Q8C092, Q8BTR2	Gene names	Taf5
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

STRAP_MOUSE
NC score	0.590220 (rank : 32)	θ value	3.41135e-07 (rank : 58)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	213
SwissProt Accessions	Q9Z1Z2	Gene names	Strap, Unrip
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein).

WSB2_HUMAN
NC score	0.589458 (rank : 33)	θ value	2.28291e-11 (rank : 11)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	218
SwissProt Accessions	Q9NYS7, Q9NRX9	Gene names	WSB2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein).

TAF5L_MOUSE
NC score	0.589047 (rank : 34)	θ value	4.92598e-06 (rank : 80)
Query Neighborhood Hits	537	Target Neighborhood Hits	337	Shared Neighborhood Hits	225
SwissProt Accessions	Q91WQ5, Q8BTL5	Gene names	Taf5l, Paf65b
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

TAF5L_HUMAN
NC score	0.588636 (rank : 35)	θ value	1.69304e-06 (rank : 68)
Query Neighborhood Hits	537	Target Neighborhood Hits	330	Shared Neighborhood Hits	225
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

WDR71_HUMAN
NC score	0.588548 (rank : 36)	θ value	0.00020696 (rank : 170)
Query Neighborhood Hits	537	Target Neighborhood Hits	241	Shared Neighborhood Hits	195
SwissProt Accessions	Q9BRP4, Q4G165, Q53HS9, Q7Z500, Q8TBU6, Q9HAB6	Gene names	WDR71
Domain Architecture	No domain graphic available
Description	WD repeat protein 71 (Protein G-16).

TBL1X_HUMAN
NC score	0.588208 (rank : 37)	θ value	2.79066e-09 (rank : 24)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	222
SwissProt Accessions	O60907, Q86UY2	Gene names	TBL1X, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein) (Transducin-beta-like 1, X-linked) (SMAP55).

TBL1R_MOUSE
NC score	0.587690 (rank : 38)	θ value	4.0297e-08 (rank : 42)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	223
SwissProt Accessions	Q8BHJ5, Q3UWL6, Q8CBG4, Q8VEG3, Q9EQD4	Gene names	Tbl1xr1, Ira1, Tblr1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1).

TBL1R_HUMAN
NC score	0.587561 (rank : 39)	θ value	4.0297e-08 (rank : 41)
Query Neighborhood Hits	537	Target Neighborhood Hits	327	Shared Neighborhood Hits	223
SwissProt Accessions	Q9BZK7, Q9H2I1, Q9H9A1	Gene names	TBL1XR1, IRA1, TBLR1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1).

TBLX_MOUSE
NC score	0.587383 (rank : 40)	θ value	1.80886e-08 (rank : 37)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	226
SwissProt Accessions	Q9QXE7, Q8BMM0, Q8BYQ4, Q8C0A1	Gene names	Tbl1x, Tbl1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein).

WDR61_MOUSE
NC score	0.587303 (rank : 41)	θ value	5.44631e-05 (rank : 131)
Query Neighborhood Hits	537	Target Neighborhood Hits	331	Shared Neighborhood Hits	224
SwissProt Accessions	Q9ERF3, Q3U562, Q9CZP1	Gene names	Wdr61
Domain Architecture	No domain graphic available
Description	WD repeat protein 61 (Meiotic recombination REC14 protein homolog).

LIS1_HUMAN
NC score	0.587303 (rank : 42)	θ value	0.00035302 (rank : 182)
Query Neighborhood Hits	537	Target Neighborhood Hits	333	Shared Neighborhood Hits	222
SwissProt Accessions	P43034, Q8WZ88, Q8WZ89	Gene names	PAFAH1B1, LIS1, MDCR, PAFAHA
Domain Architecture
Description	Platelet-activating factor acetylhydrolase IB subunit alpha (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) (Lissencephaly-1 protein) (LIS-1).

LIS1_MOUSE
NC score	0.587257 (rank : 43)	θ value	0.00035302 (rank : 183)
Query Neighborhood Hits	537	Target Neighborhood Hits	336	Shared Neighborhood Hits	222
SwissProt Accessions	P63005, O35592, P43035, P81692, Q9R2A6	Gene names	Pafah1b1, Lis-1, Lis1, Pafaha
Domain Architecture	No domain graphic available
Description	Platelet-activating factor acetylhydrolase IB subunit alpha (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) (Lissencephaly-1 protein) (LIS-1).

WDR61_HUMAN
NC score	0.587161 (rank : 44)	θ value	5.44631e-05 (rank : 130)
Query Neighborhood Hits	537	Target Neighborhood Hits	334	Shared Neighborhood Hits	225
SwissProt Accessions	Q9GZS3, Q6IA22, Q7Z4X4	Gene names	WDR61
Domain Architecture	No domain graphic available
Description	WD repeat protein 61 (Meiotic recombination REC14 protein homolog).

A16L1_HUMAN
NC score	0.586898 (rank : 45)	θ value	5.43371e-13 (rank : 7)
Query Neighborhood Hits	537	Target Neighborhood Hits	664	Shared Neighborhood Hits	235
SwissProt Accessions	Q676U5, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619	Gene names	ATG16L1, APG16L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

TBL1Y_HUMAN
NC score	0.586435 (rank : 46)	θ value	1.06045e-08 (rank : 33)
Query Neighborhood Hits	537	Target Neighborhood Hits	331	Shared Neighborhood Hits	225
SwissProt Accessions	Q9BQ87	Gene names	TBL1Y, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1Y (Transducin beta-like 1Y protein) (Transducin-beta-like 1, Y-linked).

WSB2_MOUSE
NC score	0.585714 (rank : 47)	θ value	5.08577e-11 (rank : 12)
Query Neighborhood Hits	537	Target Neighborhood Hits	306	Shared Neighborhood Hits	218
SwissProt Accessions	O54929, Q9R1M8	Gene names	Wsb2, Swip2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (SOCS box- containing WD protein SWiP-2).

GBB2_HUMAN
NC score	0.582045 (rank : 48)	θ value	4.76016e-09 (rank : 26)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	218
SwissProt Accessions	P62879, P11016, P54312	Gene names	GNB2
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit).

GBB2_MOUSE
NC score	0.582045 (rank : 49)	θ value	4.76016e-09 (rank : 27)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	218
SwissProt Accessions	P62880, P11016, P54312	Gene names	Gnb2
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit).

THOC3_HUMAN
NC score	0.581651 (rank : 50)	θ value	1.43324e-05 (rank : 99)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	221
SwissProt Accessions	Q96J01	Gene names	THOC3
Domain Architecture
Description	THO complex subunit 3 (Tho3) (TEX1 homolog).

WDR39_HUMAN
NC score	0.581223 (rank : 51)	θ value	9.92553e-07 (rank : 66)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	214
SwissProt Accessions	O76071	Gene names	WDR39, CIAO1
Domain Architecture
Description	WD repeat protein 39 (Ciao 1 protein).

APAF_MOUSE
NC score	0.580818 (rank : 52)	θ value	1.17247e-07 (rank : 47)
Query Neighborhood Hits	537	Target Neighborhood Hits	343	Shared Neighborhood Hits	224
SwissProt Accessions	O88879	Gene names	Apaf1
Domain Architecture
Description	Apoptotic protease-activating factor 1 (Apaf-1).

THOC3_MOUSE
NC score	0.580272 (rank : 53)	θ value	2.44474e-05 (rank : 111)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	221
SwissProt Accessions	Q8VE80, Q9CWI8	Gene names	Thoc3
Domain Architecture
Description	THO complex subunit 3 (Tho3).

GBB3_MOUSE
NC score	0.579938 (rank : 54)	θ value	9.59137e-10 (rank : 21)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	216
SwissProt Accessions	Q61011	Gene names	Gnb3
Domain Architecture
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 3 (Transducin beta chain 3).

GBB3_HUMAN
NC score	0.579885 (rank : 55)	θ value	7.34386e-10 (rank : 19)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	215
SwissProt Accessions	P16520, Q9BQC0	Gene names	GNB3
Domain Architecture
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 3 (Transducin beta chain 3).

FBXW7_MOUSE
NC score	0.578637 (rank : 56)	θ value	3.41135e-07 (rank : 57)
Query Neighborhood Hits	537	Target Neighborhood Hits	365	Shared Neighborhood Hits	224
SwissProt Accessions	Q8VBV4, Q8CCS5, Q8VHP4	Gene names	Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).

FBXW7_HUMAN
NC score	0.578002 (rank : 57)	θ value	8.97725e-08 (rank : 44)
Query Neighborhood Hits	537	Target Neighborhood Hits	433	Shared Neighborhood Hits	229
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

WDR17_HUMAN
NC score	0.577933 (rank : 58)	θ value	2.21117e-06 (rank : 73)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	218
SwissProt Accessions	Q8IZU2	Gene names	WDR17
Domain Architecture
Description	WD repeat protein 17.

COPA_HUMAN
NC score	0.577894 (rank : 59)	θ value	4.0297e-08 (rank : 39)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	215
SwissProt Accessions	P53621	Gene names	COPA
Domain Architecture
Description	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEPCOP) (HEP- COP) [Contains: Xenin (Xenopsin-related peptide); Proxenin].

GBB4_MOUSE
NC score	0.577193 (rank : 60)	θ value	1.38499e-08 (rank : 34)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	216
SwissProt Accessions	P29387, Q3TJJ1, Q8R475, Q9JHX8	Gene names	Gnb4
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 4 (Transducin beta chain 4).

WSB1_MOUSE
NC score	0.575861 (rank : 61)	θ value	1.87187e-05 (rank : 107)
Query Neighborhood Hits	537	Target Neighborhood Hits	313	Shared Neighborhood Hits	214
SwissProt Accessions	O54927	Gene names	Wsb1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1).

GBB4_HUMAN
NC score	0.575838 (rank : 62)	θ value	8.97725e-08 (rank : 45)
Query Neighborhood Hits	537	Target Neighborhood Hits	288	Shared Neighborhood Hits	217
SwissProt Accessions	Q9HAV0	Gene names	GNB4
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 4 (Transducin beta chain 4).

AAMP_HUMAN
NC score	0.575667 (rank : 63)	θ value	9.29e-05 (rank : 139)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	215
SwissProt Accessions	Q13685, Q8WUJ9, Q96H92	Gene names	AAMP
Domain Architecture
Description	Angio-associated migratory cell protein.

GBB1_HUMAN
NC score	0.575480 (rank : 64)	θ value	4.45536e-07 (rank : 59)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	215
SwissProt Accessions	P62873, P04697, P04901	Gene names	GNB1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 1 (Transducin beta chain 1).

GBB1_MOUSE
NC score	0.575480 (rank : 65)	θ value	4.45536e-07 (rank : 60)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	215
SwissProt Accessions	P62874, P04697, P04901	Gene names	Gnb1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 1 (Transducin beta chain 1).

PRP19_MOUSE
NC score	0.575278 (rank : 66)	θ value	0.000270298 (rank : 174)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	223
SwissProt Accessions	Q99KP6, Q3TP64, Q8BKZ5, Q8BVQ4	Gene names	Prpf19, Prp19, Snev
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor 19 (PRP19/PSO4 homolog) (Nuclear matrix protein 200) (Nuclear matrix protein SNEV).

PRP19_HUMAN
NC score	0.574350 (rank : 67)	θ value	0.000602161 (rank : 204)
Query Neighborhood Hits	537	Target Neighborhood Hits	333	Shared Neighborhood Hits	223
SwissProt Accessions	Q9UMS4	Gene names	PRPF19, NMP200, PRP19
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor 19 (PRP19/PSO4 homolog) (Nuclear matrix protein 200) (hPso4).

GBB5_HUMAN
NC score	0.572663 (rank : 68)	θ value	0.000121331 (rank : 146)
Query Neighborhood Hits	537	Target Neighborhood Hits	299	Shared Neighborhood Hits	225
SwissProt Accessions	O14775, Q9HAU9	Gene names	GNB5
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 5 (Transducin beta chain 5) (Gbeta5).

APAF_HUMAN
NC score	0.572568 (rank : 69)	θ value	0.000158464 (rank : 157)
Query Neighborhood Hits	537	Target Neighborhood Hits	334	Shared Neighborhood Hits	226
SwissProt Accessions	O14727, O43297, Q7Z438, Q9BXZ6, Q9UBZ5, Q9UGN8, Q9UGN9, Q9UGP0, Q9UJ58, Q9UJ59, Q9UJ60, Q9UJ61, Q9UJ62, Q9UJ63, Q9UJ64, Q9UJ65, Q9UJ66, Q9UJ67, Q9UNC9	Gene names	APAF1, KIAA0413
Domain Architecture
Description	Apoptotic protease-activating factor 1 (Apaf-1).

GBB5_MOUSE
NC score	0.572405 (rank : 70)	θ value	0.000158464 (rank : 160)
Query Neighborhood Hits	537	Target Neighborhood Hits	298	Shared Neighborhood Hits	225
SwissProt Accessions	P62881, O35354, P54314, Q91WB3	Gene names	Gnb5
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 5 (Transducin beta chain 5) (Gbeta5).

WSB1_HUMAN
NC score	0.572197 (rank : 71)	θ value	0.00298849 (rank : 253)
Query Neighborhood Hits	537	Target Neighborhood Hits	337	Shared Neighborhood Hits	221
SwissProt Accessions	Q9Y6I7, Q9NRB1, Q9UBH9, Q9UNN6	Gene names	WSB1, SWIP1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box- containing WD protein SWiP-1).

FBW1B_HUMAN
NC score	0.571489 (rank : 72)	θ value	7.1131e-05 (rank : 133)
Query Neighborhood Hits	537	Target Neighborhood Hits	327	Shared Neighborhood Hits	221
SwissProt Accessions	Q9UKB1, Q9P2S8, Q9P2S9, Q9Y4C6	Gene names	FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Domain Architecture
Description	F-box/WD repeat protein 11 (F-box/WD repeat protein 1B) (F-box and WD repeats protein beta-TrCP2).

PLRG1_HUMAN
NC score	0.571190 (rank : 73)	θ value	0.000602161 (rank : 203)
Query Neighborhood Hits	537	Target Neighborhood Hits	318	Shared Neighborhood Hits	221
SwissProt Accessions	O43660, Q8WUD8	Gene names	PLRG1
Domain Architecture
Description	Pleiotropic regulator 1.

PLRG1_MOUSE
NC score	0.569417 (rank : 74)	θ value	0.00102713 (rank : 222)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	220
SwissProt Accessions	Q922V4, O55039	Gene names	Plrg1
Domain Architecture
Description	Pleiotropic regulator 1.

FBW1A_HUMAN
NC score	0.569412 (rank : 75)	θ value	0.000121331 (rank : 145)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	220
SwissProt Accessions	Q9Y297, Q9Y213	Gene names	BTRC, BTRCP, FBW1A, FBXW1A
Domain Architecture
Description	F-box/WD repeat protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit).

A16L1_MOUSE
NC score	0.569006 (rank : 76)	θ value	1.02475e-11 (rank : 10)
Query Neighborhood Hits	537	Target Neighborhood Hits	776	Shared Neighborhood Hits	237
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

UTP15_MOUSE
NC score	0.568134 (rank : 77)	θ value	1.43324e-05 (rank : 100)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	216
SwissProt Accessions	Q8C7V3, Q3TRG8, Q8K231	Gene names	Utp15
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 15 homolog (Src-associated protein SAW).

U3IP2_HUMAN
NC score	0.567071 (rank : 78)	θ value	1.69304e-06 (rank : 69)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	215
SwissProt Accessions	O43818, Q8IZ30	Gene names	RNU3IP2, U355K
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

U3IP2_MOUSE
NC score	0.565706 (rank : 79)	θ value	5.81887e-07 (rank : 63)
Query Neighborhood Hits	537	Target Neighborhood Hits	312	Shared Neighborhood Hits	215
SwissProt Accessions	Q91WM3, Q8CFB7	Gene names	Rnu3ip2, U3-55k
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

WDR26_HUMAN
NC score	0.564647 (rank : 80)	θ value	0.000461057 (rank : 196)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	220
SwissProt Accessions	Q9H7D7, Q86UY4	Gene names	WDR26
Domain Architecture
Description	WD repeat protein 26.

WDR37_HUMAN
NC score	0.563962 (rank : 81)	θ value	1.87187e-05 (rank : 106)
Query Neighborhood Hits	537	Target Neighborhood Hits	303	Shared Neighborhood Hits	210
SwissProt Accessions	Q9Y2I8, Q5SW03, Q9NTJ6	Gene names	WDR37, KIAA0982
Domain Architecture
Description	WD repeat protein 37.

WDR26_MOUSE
NC score	0.563256 (rank : 82)	θ value	0.000602161 (rank : 209)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	220
SwissProt Accessions	Q8C6G8, Q8C4F3, Q8VDZ6	Gene names	Wdr26
Domain Architecture
Description	WD repeat protein 26.

WDR37_MOUSE
NC score	0.559877 (rank : 83)	θ value	0.0113563 (rank : 282)
Query Neighborhood Hits	537	Target Neighborhood Hits	298	Shared Neighborhood Hits	211
SwissProt Accessions	Q8CBE3, Q80Y96, Q8CCL2	Gene names	Wdr37, Kiaa0982
Domain Architecture
Description	WD repeat protein 37.

PWP2_HUMAN
NC score	0.558274 (rank : 84)	θ value	0.000158464 (rank : 163)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	220
SwissProt Accessions	Q15269, Q96A77	Gene names	PWP2H, PWP2
Domain Architecture
Description	Periodic tryptophan protein 2 homolog.

WDR3_HUMAN
NC score	0.557734 (rank : 85)	θ value	0.0193708 (rank : 290)
Query Neighborhood Hits	537	Target Neighborhood Hits	334	Shared Neighborhood Hits	220
SwissProt Accessions	Q9UNX4	Gene names	WDR3
Domain Architecture
Description	WD repeat protein 3.

WDR12_HUMAN
NC score	0.556673 (rank : 86)	θ value	0.000270298 (rank : 177)
Query Neighborhood Hits	537	Target Neighborhood Hits	300	Shared Neighborhood Hits	212
SwissProt Accessions	Q9GZL7, Q96HU0, Q9NV80, Q9NYI8	Gene names	WDR12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

WDR48_HUMAN
NC score	0.555661 (rank : 87)	θ value	0.00175202 (rank : 241)
Query Neighborhood Hits	537	Target Neighborhood Hits	291	Shared Neighborhood Hits	214
SwissProt Accessions	Q8TAF3, Q63HJ2, Q658Y1, Q8N3Z1, Q9NSK8, Q9P279	Gene names	WDR48, KIAA1449
Domain Architecture	No domain graphic available
Description	WD repeat protein 48 (WD repeat endosomal protein) (p80).

UTP15_HUMAN
NC score	0.555238 (rank : 88)	θ value	0.000121331 (rank : 154)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	214
SwissProt Accessions	Q8TED0, Q6IA60, Q96E08, Q9H9F8	Gene names	UTP15
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 15 homolog.

WDR48_MOUSE
NC score	0.554992 (rank : 89)	θ value	0.00228821 (rank : 246)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	214
SwissProt Accessions	Q8BH57, Q80TD4, Q80XI0, Q8BRM0, Q8CBK0, Q922Z9, Q9CRR1, Q9CSL0	Gene names	Wdr48, Kiaa1449
Domain Architecture	No domain graphic available
Description	WD repeat protein 48.

PWP2_MOUSE
NC score	0.553295 (rank : 90)	θ value	0.00102713 (rank : 223)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	218
SwissProt Accessions	Q8BU03, Q8BTR0	Gene names	Pwp2h
Domain Architecture
Description	Periodic tryptophan protein 2 homolog.

CAF1B_HUMAN
NC score	0.552897 (rank : 91)	θ value	0.00035302 (rank : 179)
Query Neighborhood Hits	537	Target Neighborhood Hits	345	Shared Neighborhood Hits	215
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

WDR1_MOUSE
NC score	0.552676 (rank : 92)	θ value	0.000121331 (rank : 155)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	212
SwissProt Accessions	O88342	Gene names	Wdr1
Domain Architecture
Description	WD repeat protein 1 (Actin-interacting protein 1) (AIP1).

WDR12_MOUSE
NC score	0.552434 (rank : 93)	θ value	0.00102713 (rank : 227)
Query Neighborhood Hits	537	Target Neighborhood Hits	301	Shared Neighborhood Hits	214
SwissProt Accessions	Q9JJA4, Q9CST3, Q9JKF5	Gene names	Wdr12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

PEX7_MOUSE
NC score	0.551313 (rank : 94)	θ value	0.00869519 (rank : 275)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	212
SwissProt Accessions	P97865	Gene names	Pex7
Domain Architecture
Description	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7).

CAF1B_MOUSE
NC score	0.550368 (rank : 95)	θ value	0.00134147 (rank : 228)
Query Neighborhood Hits	537	Target Neighborhood Hits	385	Shared Neighborhood Hits	223
SwissProt Accessions	Q9D0N7	Gene names	Chaf1b
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60).

WDR1_HUMAN
NC score	0.550175 (rank : 96)	θ value	7.1131e-05 (rank : 138)
Query Neighborhood Hits	537	Target Neighborhood Hits	292	Shared Neighborhood Hits	211
SwissProt Accessions	O75083, O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0	Gene names	WDR1
Domain Architecture
Description	WD repeat protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1).

PEX7_HUMAN
NC score	0.548523 (rank : 97)	θ value	0.0330416 (rank : 294)
Query Neighborhood Hits	537	Target Neighborhood Hits	275	Shared Neighborhood Hits	212
SwissProt Accessions	O00628	Gene names	PEX7, PTS2R
Domain Architecture
Description	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7).

RBBP5_HUMAN
NC score	0.544530 (rank : 98)	θ value	1.63604e-09 (rank : 23)
Query Neighborhood Hits	537	Target Neighborhood Hits	372	Shared Neighborhood Hits	177
SwissProt Accessions	Q15291	Gene names	RBBP5, RBQ3
Domain Architecture
Description	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3).

COPB2_HUMAN
NC score	0.542915 (rank : 99)	θ value	0.0961366 (rank : 321)
Query Neighborhood Hits	537	Target Neighborhood Hits	315	Shared Neighborhood Hits	223
SwissProt Accessions	P35606	Gene names	COPB2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

COPB2_MOUSE
NC score	0.542863 (rank : 100)	θ value	0.0961366 (rank : 322)
Query Neighborhood Hits	537	Target Neighborhood Hits	315	Shared Neighborhood Hits	223
SwissProt Accessions	O55029, Q3U5Z9	Gene names	Copb2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

PLAP_MOUSE
NC score	0.538267 (rank : 101)	θ value	9.29e-05 (rank : 142)
Query Neighborhood Hits	537	Target Neighborhood Hits	261	Shared Neighborhood Hits	203
SwissProt Accessions	P27612, Q8C6C4	Gene names	Plaa, Plap
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP).

PWP1_MOUSE
NC score	0.536535 (rank : 102)	θ value	3.19293e-05 (rank : 116)
Query Neighborhood Hits	537	Target Neighborhood Hits	278	Shared Neighborhood Hits	200
SwissProt Accessions	Q99LL5, Q9D6T6	Gene names	Pwp1
Domain Architecture	No domain graphic available
Description	Periodic tryptophan protein 1 homolog.

PLAP_HUMAN
NC score	0.535763 (rank : 103)	θ value	0.000121331 (rank : 151)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	202
SwissProt Accessions	Q9Y263, Q53EU5, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1	Gene names	PLAA, PLAP
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP) (PLA2P).

BRWD1_HUMAN
NC score	0.535522 (rank : 104)	θ value	1.99992e-07 (rank : 52)
Query Neighborhood Hits	537	Target Neighborhood Hits	448	Shared Neighborhood Hits	229
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

BRWD1_MOUSE
NC score	0.534361 (rank : 105)	θ value	5.81887e-07 (rank : 61)
Query Neighborhood Hits	537	Target Neighborhood Hits	478	Shared Neighborhood Hits	227
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

WDR31_HUMAN
NC score	0.530930 (rank : 106)	θ value	0.365318 (rank : 381)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	216
SwissProt Accessions	Q8NA23, Q96EG8	Gene names	WDR31
Domain Architecture
Description	WD repeat protein 31.

WDR31_MOUSE
NC score	0.528757 (rank : 107)	θ value	0.62314 (rank : 396)
Query Neighborhood Hits	537	Target Neighborhood Hits	287	Shared Neighborhood Hits	217
SwissProt Accessions	Q9JHB4, Q3URZ0, Q9D3N4	Gene names	Wdr31
Domain Architecture
Description	WD repeat protein 31 (Spermatid WD repeat protein) (spWD).

WDR23_MOUSE
NC score	0.524835 (rank : 108)	θ value	0.00035302 (rank : 189)
Query Neighborhood Hits	537	Target Neighborhood Hits	271	Shared Neighborhood Hits	204
SwissProt Accessions	Q91VU6, Q3U836, Q8JZV8	Gene names	Wdr23, D14Ucla1
Domain Architecture
Description	WD repeat protein 23.

WDR23_HUMAN
NC score	0.522895 (rank : 109)	θ value	0.00035302 (rank : 188)
Query Neighborhood Hits	537	Target Neighborhood Hits	267	Shared Neighborhood Hits	205
SwissProt Accessions	Q8TEB1, Q86U00, Q86U39, Q8NDN2, Q9H2J0, Q9H3A3, Q9H5C9	Gene names	WDR23
Domain Architecture
Description	WD repeat protein 23.

PWP1_HUMAN
NC score	0.515880 (rank : 110)	θ value	0.00035302 (rank : 185)
Query Neighborhood Hits	537	Target Neighborhood Hits	261	Shared Neighborhood Hits	193
SwissProt Accessions	Q13610	Gene names	PWP1
Domain Architecture
Description	Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502).

WDR33_HUMAN
NC score	0.510050 (rank : 111)	θ value	1.43324e-05 (rank : 103)
Query Neighborhood Hits	537	Target Neighborhood Hits	638	Shared Neighborhood Hits	229
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

CDC20_HUMAN
NC score	0.509181 (rank : 112)	θ value	1.81305 (rank : 434)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	208
SwissProt Accessions	Q12834, Q9BW56, Q9UQI9	Gene names	CDC20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC).

CSTF1_MOUSE
NC score	0.509146 (rank : 113)	θ value	4.03905 (rank : 471)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	211
SwissProt Accessions	Q99LC2, Q3UMB8, Q8BJW1, Q9CSU8	Gene names	Cstf1
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit) (CF-1 50 kDa subunit) (CstF-50).

PK1IP_HUMAN
NC score	0.508234 (rank : 114)	θ value	0.00175202 (rank : 235)
Query Neighborhood Hits	537	Target Neighborhood Hits	277	Shared Neighborhood Hits	196
SwissProt Accessions	Q9NWT1, Q5T4J2, Q96QJ8, Q96T87	Gene names	PAK1IP1, PIP1, WDR84
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (PAK/PLC-interacting protein 1) (hPIP1) (WD repeat protein 84).

CDC20_MOUSE
NC score	0.508145 (rank : 115)	θ value	1.06291 (rank : 409)
Query Neighborhood Hits	537	Target Neighborhood Hits	325	Shared Neighborhood Hits	208
SwissProt Accessions	Q9JJ66, Q3TGP1, Q8BPG4, Q99LK3	Gene names	Cdc20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC) (mmCdc20).

PK1IP_MOUSE
NC score	0.508138 (rank : 116)	θ value	0.0431538 (rank : 302)
Query Neighborhood Hits	537	Target Neighborhood Hits	313	Shared Neighborhood Hits	206
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

ERCC8_HUMAN
NC score	0.507813 (rank : 117)	θ value	0.0563607 (rank : 304)
Query Neighborhood Hits	537	Target Neighborhood Hits	267	Shared Neighborhood Hits	205
SwissProt Accessions	Q13216, Q6FHX5, Q96GB9	Gene names	ERCC8, CKN1, CSA
Domain Architecture
Description	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA).

WDR36_HUMAN
NC score	0.507149 (rank : 118)	θ value	0.163984 (rank : 353)
Query Neighborhood Hits	537	Target Neighborhood Hits	274	Shared Neighborhood Hits	210
SwissProt Accessions	Q8NI36, Q8N1Q2	Gene names	WDR36
Domain Architecture
Description	WD repeat protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP).

WDHD1_MOUSE
NC score	0.505176 (rank : 119)	θ value	3.77169e-06 (rank : 77)
Query Neighborhood Hits	537	Target Neighborhood Hits	414	Shared Neighborhood Hits	217
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

WDR47_HUMAN
NC score	0.504682 (rank : 120)	θ value	1.81305 (rank : 442)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	204
SwissProt Accessions	O94967, Q8IXT7, Q8IYU9	Gene names	WDR47, KIAA0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

WDR47_MOUSE
NC score	0.504594 (rank : 121)	θ value	1.81305 (rank : 443)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	203
SwissProt Accessions	Q8CGF6, Q80TP4	Gene names	Wdr47, Kiaa0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

ERCC8_MOUSE
NC score	0.502280 (rank : 122)	θ value	0.0431538 (rank : 299)
Query Neighborhood Hits	537	Target Neighborhood Hits	269	Shared Neighborhood Hits	208
SwissProt Accessions	Q8CFD5, Q3U066, Q8VDC4, Q9CWK7	Gene names	Ercc8, Ckn1, Csa
Domain Architecture	No domain graphic available
Description	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA homolog).

CSTF1_HUMAN
NC score	0.502254 (rank : 123)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	210
SwissProt Accessions	Q05048	Gene names	CSTF1
Domain Architecture
Description	Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit) (CF-1 50 kDa subunit) (CstF-50).

IF32_MOUSE
NC score	0.501475 (rank : 124)	θ value	0.163984 (rank : 348)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	189
SwissProt Accessions	Q9QZD9	Gene names	Eif3s2, Trip1
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 2 (eIF-3 beta) (eIF3 p36) (eIF3i) (TGF-beta receptor-interacting protein 1) (TRIP-1).

FBXW2_HUMAN
NC score	0.501469 (rank : 125)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	537	Target Neighborhood Hits	260	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UKT8, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3	Gene names	FBXW2, FBW2, FWD2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

IF32_HUMAN
NC score	0.501000 (rank : 126)	θ value	0.163984 (rank : 347)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	189
SwissProt Accessions	Q13347	Gene names	EIF3S2, TRIP1
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 2 (eIF-3 beta) (eIF3 p36) (eIF3i) (TGF-beta receptor-interacting protein 1) (TRIP-1).

TEP1_MOUSE
NC score	0.499589 (rank : 127)	θ value	0.0736092 (rank : 319)
Query Neighborhood Hits	537	Target Neighborhood Hits	344	Shared Neighborhood Hits	222
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

WDHD1_HUMAN
NC score	0.499192 (rank : 128)	θ value	1.43324e-05 (rank : 101)
Query Neighborhood Hits	537	Target Neighborhood Hits	342	Shared Neighborhood Hits	190
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

IF122_HUMAN
NC score	0.498199 (rank : 129)	θ value	1.87187e-05 (rank : 105)
Query Neighborhood Hits	537	Target Neighborhood Hits	244	Shared Neighborhood Hits	192
SwissProt Accessions	Q9HBG6	Gene names	IFT122, WDR10, WDR140
Domain Architecture
Description	Intraflagellar transport 122 homolog (WD repeat protein 10).

TEP1_HUMAN
NC score	0.498120 (rank : 130)	θ value	0.279714 (rank : 365)
Query Neighborhood Hits	537	Target Neighborhood Hits	371	Shared Neighborhood Hits	224
SwissProt Accessions	Q99973	Gene names	TEP1, TLP1, TP1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog).

WDR18_HUMAN
NC score	0.497945 (rank : 131)	θ value	1.43324e-05 (rank : 102)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	198
SwissProt Accessions	Q9BV38, O60390, Q9BWR2	Gene names	WDR18
Domain Architecture
Description	WD repeat protein 18.

FZR_MOUSE
NC score	0.497298 (rank : 132)	θ value	1.38821 (rank : 428)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	211
SwissProt Accessions	Q9R1K5	Gene names	Fzr1, Fyr, Fzr
Domain Architecture
Description	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog).

FBXW2_MOUSE
NC score	0.497123 (rank : 133)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	537	Target Neighborhood Hits	249	Shared Neighborhood Hits	197
SwissProt Accessions	Q60584	Gene names	Fbxw2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

FZR_HUMAN
NC score	0.497112 (rank : 134)	θ value	0.62314 (rank : 392)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UM11, O75869, Q86U66, Q96NW8, Q9UI96, Q9ULH8, Q9UM10, Q9UNQ1, Q9Y2T8	Gene names	FZR1, CDH1, FYR, FZR, KIAA1242
Domain Architecture
Description	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) (hCDH1) (CDC20-like protein 1).

TBL2_HUMAN
NC score	0.496136 (rank : 135)	θ value	0.00298849 (rank : 252)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	182
SwissProt Accessions	Q9Y4P3, Q9UQE2	Gene names	TBL2, WBSCR13
Domain Architecture
Description	Transducin beta-like 2 protein (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosome region 13 protein).

WDR16_MOUSE
NC score	0.495613 (rank : 136)	θ value	0.47712 (rank : 387)
Query Neighborhood Hits	537	Target Neighborhood Hits	269	Shared Neighborhood Hits	202
SwissProt Accessions	Q5F201, Q5F200, Q9D432, Q9DA68	Gene names	WDR16
Domain Architecture	No domain graphic available
Description	WD repeat protein 16.

WDR16_HUMAN
NC score	0.491989 (rank : 137)	θ value	1.81305 (rank : 441)
Query Neighborhood Hits	537	Target Neighborhood Hits	275	Shared Neighborhood Hits	205
SwissProt Accessions	Q8N1V2, Q5DX23, Q8TC73, Q8TCI3	Gene names	WDR16, WDRPUH
Domain Architecture	No domain graphic available
Description	WD repeat protein 16 (WD40-repeat protein up-regulated in HCC).

GNB1L_MOUSE
NC score	0.488990 (rank : 138)	θ value	0.0252991 (rank : 291)
Query Neighborhood Hits	537	Target Neighborhood Hits	231	Shared Neighborhood Hits	180
SwissProt Accessions	Q9EQ15, Q8R1F3, Q9CWP2, Q9D3Y1	Gene names	Gnb1l, Estm55, Wdr14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF).

WDR65_HUMAN
NC score	0.487482 (rank : 139)	θ value	0.00390308 (rank : 260)
Query Neighborhood Hits	537	Target Neighborhood Hits	238	Shared Neighborhood Hits	188
SwissProt Accessions	Q96MR6, Q5TAI0	Gene names	WDR65
Domain Architecture	No domain graphic available
Description	WD repeat protein 65.

RAE1L_MOUSE
NC score	0.484371 (rank : 140)	θ value	0.000461057 (rank : 194)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	179
SwissProt Accessions	Q8C570, Q3UKD4	Gene names	Rae1, Mrnp41
Domain Architecture	No domain graphic available
Description	mRNA-associated protein mrnp 41 (Rae1 protein homolog).

CORO7_MOUSE
NC score	0.481743 (rank : 141)	θ value	0.000786445 (rank : 210)
Query Neighborhood Hits	537	Target Neighborhood Hits	312	Shared Neighborhood Hits	217
SwissProt Accessions	Q9D2V7, Q3UDJ4, Q6P8Y8, Q8C9V7	Gene names	Coro7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

RAE1L_HUMAN
NC score	0.480192 (rank : 142)	θ value	0.00175202 (rank : 237)
Query Neighborhood Hits	537	Target Neighborhood Hits	222	Shared Neighborhood Hits	178
SwissProt Accessions	P78406, O15306, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6	Gene names	RAE1, MRNP41
Domain Architecture
Description	mRNA-associated protein mrnp 41 (Rae1 protein homolog).

GRWD1_MOUSE
NC score	0.478154 (rank : 143)	θ value	0.47712 (rank : 383)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	215
SwissProt Accessions	Q810D6, Q922H3	Gene names	Grwd1, A301
Domain Architecture	No domain graphic available
Description	Glutamate-rich WD repeat-containing protein 1 (Protein A301).

GRWD1_HUMAN
NC score	0.477285 (rank : 144)	θ value	1.06291 (rank : 414)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	215
SwissProt Accessions	Q9BQ67	Gene names	GRWD1, GRWD, WDR28
Domain Architecture
Description	Glutamate-rich WD repeat-containing protein 1.

TBL2_MOUSE
NC score	0.473787 (rank : 145)	θ value	0.0961366 (rank : 332)
Query Neighborhood Hits	537	Target Neighborhood Hits	221	Shared Neighborhood Hits	184
SwissProt Accessions	Q9R099	Gene names	Tbl2
Domain Architecture
Description	Transducin beta-like 2 protein.

CORO7_HUMAN
NC score	0.473126 (rank : 146)	θ value	0.000602161 (rank : 199)
Query Neighborhood Hits	537	Target Neighborhood Hits	315	Shared Neighborhood Hits	209
SwissProt Accessions	P57737	Gene names	CORO7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

WDR18_MOUSE
NC score	0.469922 (rank : 147)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	191
SwissProt Accessions	Q4VBE8	Gene names	Wdr18
Domain Architecture	No domain graphic available
Description	WD repeat protein 18.

STRN4_HUMAN
NC score	0.469523 (rank : 148)	θ value	0.813845 (rank : 407)
Query Neighborhood Hits	537	Target Neighborhood Hits	325	Shared Neighborhood Hits	216
SwissProt Accessions	Q9NRL3	Gene names	STRN4, ZIN
Domain Architecture
Description	Striatin-4 (Zinedin).

STRN4_MOUSE
NC score	0.468465 (rank : 149)	θ value	0.47712 (rank : 385)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	213
SwissProt Accessions	P58404, Q68EF5	Gene names	Strn4, Zin
Domain Architecture
Description	Striatin-4 (Zinedin).

HIRA_MOUSE
NC score	0.468366 (rank : 150)	θ value	0.813845 (rank : 403)
Query Neighborhood Hits	537	Target Neighborhood Hits	274	Shared Neighborhood Hits	199
SwissProt Accessions	Q61666, O08845, Q62365	Gene names	Hira, Tuple1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

WDR13_HUMAN
NC score	0.467708 (rank : 151)	θ value	8.40245e-06 (rank : 87)
Query Neighborhood Hits	537	Target Neighborhood Hits	186	Shared Neighborhood Hits	163
SwissProt Accessions	Q9H1Z4, Q9BUL7, Q9NWW4	Gene names	WDR13
Domain Architecture
Description	WD repeat protein 13.

HIRA_HUMAN
NC score	0.466574 (rank : 152)	θ value	0.813845 (rank : 402)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	200
SwissProt Accessions	P54198, Q8IXN2	Gene names	HIRA, DGCR1, HIR, TUPLE1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

WDR22_MOUSE
NC score	0.466007 (rank : 153)	θ value	0.00390308 (rank : 259)
Query Neighborhood Hits	537	Target Neighborhood Hits	302	Shared Neighborhood Hits	191
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

RBBP4_MOUSE
NC score	0.465820 (rank : 154)	θ value	0.0563607 (rank : 309)
Query Neighborhood Hits	537	Target Neighborhood Hits	289	Shared Neighborhood Hits	210
SwissProt Accessions	Q60972	Gene names	Rbbp4, Rbap48
Domain Architecture
Description	Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome remodeling factor subunit RBAP48).

RBBP4_HUMAN
NC score	0.464633 (rank : 155)	θ value	0.0563607 (rank : 308)
Query Neighborhood Hits	537	Target Neighborhood Hits	291	Shared Neighborhood Hits	211
SwissProt Accessions	Q09028, P31149, Q53H02, Q96BV9	Gene names	RBBP4, RBAP48
Domain Architecture
Description	Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome remodeling factor subunit RBAP48).

WDR22_HUMAN
NC score	0.463480 (rank : 156)	θ value	0.00390308 (rank : 258)
Query Neighborhood Hits	537	Target Neighborhood Hits	328	Shared Neighborhood Hits	193
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

RBBP7_HUMAN
NC score	0.462888 (rank : 157)	θ value	0.365318 (rank : 374)
Query Neighborhood Hits	537	Target Neighborhood Hits	285	Shared Neighborhood Hits	210
SwissProt Accessions	Q16576	Gene names	RBBP7, RBAP46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

RBBP7_MOUSE
NC score	0.462685 (rank : 158)	θ value	0.365318 (rank : 375)
Query Neighborhood Hits	537	Target Neighborhood Hits	285	Shared Neighborhood Hits	210
SwissProt Accessions	Q60973, Q3UX20	Gene names	Rbbp7, Rbap46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

STRN_MOUSE
NC score	0.461422 (rank : 159)	θ value	0.0148317 (rank : 288)
Query Neighborhood Hits	537	Target Neighborhood Hits	326	Shared Neighborhood Hits	215
SwissProt Accessions	O55106	Gene names	Strn
Domain Architecture
Description	Striatin.

FAN_HUMAN
NC score	0.459683 (rank : 160)	θ value	0.00175202 (rank : 233)
Query Neighborhood Hits	537	Target Neighborhood Hits	295	Shared Neighborhood Hits	214
SwissProt Accessions	Q92636	Gene names	NSMAF, FAN
Domain Architecture
Description	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation).

STRN_HUMAN
NC score	0.458357 (rank : 161)	θ value	0.00509761 (rank : 265)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	211
SwissProt Accessions	O43815, Q9NP38	Gene names	STRN
Domain Architecture
Description	Striatin.

WDR53_HUMAN
NC score	0.456801 (rank : 162)	θ value	3.0926 (rank : 468)
Query Neighborhood Hits	537	Target Neighborhood Hits	251	Shared Neighborhood Hits	205
SwissProt Accessions	Q7Z5U6	Gene names	WDR53
Domain Architecture	No domain graphic available
Description	WD repeat protein 53.

FAN_MOUSE
NC score	0.454716 (rank : 163)	θ value	0.000121331 (rank : 144)
Query Neighborhood Hits	537	Target Neighborhood Hits	292	Shared Neighborhood Hits	206
SwissProt Accessions	O35242	Gene names	Nsmaf, Fan
Domain Architecture
Description	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation).

TRAF7_MOUSE
NC score	0.453180 (rank : 164)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	537	Target Neighborhood Hits	470	Shared Neighborhood Hits	212
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

WDR13_MOUSE
NC score	0.451442 (rank : 165)	θ value	3.19293e-05 (rank : 121)
Query Neighborhood Hits	537	Target Neighborhood Hits	195	Shared Neighborhood Hits	166
SwissProt Accessions	Q91V09	Gene names	Wdr13
Domain Architecture
Description	WD repeat protein 13.

TRAF7_HUMAN
NC score	0.450712 (rank : 166)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	537	Target Neighborhood Hits	482	Shared Neighborhood Hits	213
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

WDR55_HUMAN
NC score	0.450096 (rank : 167)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	537	Target Neighborhood Hits	231	Shared Neighborhood Hits	184
SwissProt Accessions	Q9H6Y2	Gene names	WDR55
Domain Architecture	No domain graphic available
Description	WD repeat protein 55.

WDR79_MOUSE
NC score	0.448681 (rank : 168)	θ value	0.163984 (rank : 354)
Query Neighborhood Hits	537	Target Neighborhood Hits	216	Shared Neighborhood Hits	169
SwissProt Accessions	Q8VC51	Gene names	Wdr79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

STRN3_HUMAN
NC score	0.448210 (rank : 169)	θ value	0.365318 (rank : 376)
Query Neighborhood Hits	537	Target Neighborhood Hits	316	Shared Neighborhood Hits	204
SwissProt Accessions	Q13033, Q9NRA5	Gene names	STRN3, GS2NA, SG2NA
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

STRN3_MOUSE
NC score	0.447300 (rank : 170)	θ value	0.365318 (rank : 377)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ERG2	Gene names	Strn3, Gs2na, Sg2na
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

CD2AP_MOUSE
NC score	0.446393 (rank : 171)	θ value	1.87187e-05 (rank : 104)
Query Neighborhood Hits	537	Target Neighborhood Hits	336	Shared Neighborhood Hits	200
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NEDD1_MOUSE
NC score	0.445147 (rank : 172)	θ value	0.365318 (rank : 373)
Query Neighborhood Hits	537	Target Neighborhood Hits	281	Shared Neighborhood Hits	184
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

ABI2_MOUSE
NC score	0.443193 (rank : 173)	θ value	1.53129e-07 (rank : 51)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	184
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

GEMI5_HUMAN
NC score	0.442516 (rank : 174)	θ value	0.0148317 (rank : 287)
Query Neighborhood Hits	537	Target Neighborhood Hits	362	Shared Neighborhood Hits	221
SwissProt Accessions	Q8TEQ6, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5	Gene names	GEMIN5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

WDR53_MOUSE
NC score	0.441758 (rank : 175)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	537	Target Neighborhood Hits	254	Shared Neighborhood Hits	201
SwissProt Accessions	Q9DB94	Gene names	Wdr53
Domain Architecture	No domain graphic available
Description	WD repeat protein 53.

SH3K1_HUMAN
NC score	0.441673 (rank : 176)	θ value	8.40245e-06 (rank : 85)
Query Neighborhood Hits	537	Target Neighborhood Hits	341	Shared Neighborhood Hits	198
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CD2AP_HUMAN
NC score	0.441466 (rank : 177)	θ value	0.000158464 (rank : 158)
Query Neighborhood Hits	537	Target Neighborhood Hits	315	Shared Neighborhood Hits	197
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

COR2B_MOUSE
NC score	0.440038 (rank : 178)	θ value	3.77169e-06 (rank : 75)
Query Neighborhood Hits	537	Target Neighborhood Hits	235	Shared Neighborhood Hits	183
SwissProt Accessions	Q8BH44, Q6P5U9	Gene names	Coro2b
Domain Architecture	No domain graphic available
Description	Coronin-2B.

NEDD1_HUMAN
NC score	0.439408 (rank : 179)	θ value	1.06291 (rank : 416)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	185
SwissProt Accessions	Q8NHV4, Q8NA30	Gene names	NEDD1
Domain Architecture	No domain graphic available
Description	Protein NEDD1.

GRAP2_HUMAN
NC score	0.439139 (rank : 180)	θ value	1.09739e-05 (rank : 90)
Query Neighborhood Hits	537	Target Neighborhood Hits	304	Shared Neighborhood Hits	196
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

WDR55_MOUSE
NC score	0.439050 (rank : 181)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	537	Target Neighborhood Hits	236	Shared Neighborhood Hits	181
SwissProt Accessions	Q9CX97	Gene names	Wdr55
Domain Architecture	No domain graphic available
Description	WD repeat protein 55.

ABI2_HUMAN
NC score	0.438987 (rank : 182)	θ value	1.53129e-07 (rank : 50)
Query Neighborhood Hits	537	Target Neighborhood Hits	350	Shared Neighborhood Hits	186
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

GRB2_HUMAN
NC score	0.438034 (rank : 183)	θ value	9.29e-05 (rank : 140)
Query Neighborhood Hits	537	Target Neighborhood Hits	310	Shared Neighborhood Hits	196
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.437626 (rank : 184)	θ value	0.000121331 (rank : 147)
Query Neighborhood Hits	537	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

WDR43_HUMAN
NC score	0.437570 (rank : 185)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	537	Target Neighborhood Hits	269	Shared Neighborhood Hits	162
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

COR2B_HUMAN
NC score	0.437337 (rank : 186)	θ value	6.43352e-06 (rank : 83)
Query Neighborhood Hits	537	Target Neighborhood Hits	233	Shared Neighborhood Hits	181
SwissProt Accessions	Q9UQ03, O94767, Q8TAN1	Gene names	CORO2B, KIAA0925
Domain Architecture
Description	Coronin-2B (Coronin-like protein C) (ClipinC) (Protein FC96).

GRAP2_MOUSE
NC score	0.436947 (rank : 187)	θ value	0.000158464 (rank : 161)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	194
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

WDR79_HUMAN
NC score	0.436614 (rank : 188)	θ value	0.00390308 (rank : 261)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q9BUR4, Q9NW09	Gene names	WDR79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

GEMI5_MOUSE
NC score	0.436603 (rank : 189)	θ value	0.0563607 (rank : 305)
Query Neighborhood Hits	537	Target Neighborhood Hits	424	Shared Neighborhood Hits	225
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

SH3K1_MOUSE
NC score	0.435306 (rank : 190)	θ value	9.29e-05 (rank : 143)
Query Neighborhood Hits	537	Target Neighborhood Hits	332	Shared Neighborhood Hits	197
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CORO6_MOUSE
NC score	0.434611 (rank : 191)	θ value	4.1701e-05 (rank : 125)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	179
SwissProt Accessions	Q920M5, Q920M3, Q920M4	Gene names	Coro6
Domain Architecture	No domain graphic available
Description	Coronin-6 (Clipin E).

GRAP_MOUSE
NC score	0.430726 (rank : 192)	θ value	7.1131e-05 (rank : 134)
Query Neighborhood Hits	537	Target Neighborhood Hits	309	Shared Neighborhood Hits	200
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.430671 (rank : 193)	θ value	2.44474e-05 (rank : 109)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	201
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK1_HUMAN
NC score	0.429367 (rank : 194)	θ value	7.1131e-05 (rank : 136)
Query Neighborhood Hits	537	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

WDR24_MOUSE
NC score	0.429219 (rank : 195)	θ value	1.38821 (rank : 431)
Query Neighborhood Hits	537	Target Neighborhood Hits	286	Shared Neighborhood Hits	193
SwissProt Accessions	Q8CFJ9	Gene names	Wdr24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

GNB1L_HUMAN
NC score	0.428732 (rank : 196)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	537	Target Neighborhood Hits	221	Shared Neighborhood Hits	169
SwissProt Accessions	Q9BYB4, Q9H2S2, Q9H4M4	Gene names	GNB1L, GY2, KIAA1645, WDR14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF) (DGCRK3).

NCK2_HUMAN
NC score	0.427842 (rank : 197)	θ value	0.000121331 (rank : 149)
Query Neighborhood Hits	537	Target Neighborhood Hits	310	Shared Neighborhood Hits	196
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

WDR49_HUMAN
NC score	0.427454 (rank : 198)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	537	Target Neighborhood Hits	214	Shared Neighborhood Hits	167
SwissProt Accessions	Q8IV35, Q8N297	Gene names	WDR49
Domain Architecture	No domain graphic available
Description	WD repeat protein 49.

STTP1_MOUSE
NC score	0.427454 (rank : 199)	θ value	0.00665767 (rank : 269)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	205
SwissProt Accessions	Q91WG4, Q3TIH5, Q3TIT0, Q8CBW6, Q9ESY7	Gene names	Statip1
Domain Architecture	No domain graphic available
Description	Stat3-interacting protein (StIP1).

NCF2_HUMAN
NC score	0.425958 (rank : 200)	θ value	0.00298849 (rank : 249)
Query Neighborhood Hits	537	Target Neighborhood Hits	229	Shared Neighborhood Hits	174
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ABI1_MOUSE
NC score	0.416310 (rank : 201)	θ value	1.43324e-05 (rank : 93)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	177
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

COR2A_HUMAN
NC score	0.414179 (rank : 202)	θ value	6.43352e-06 (rank : 82)
Query Neighborhood Hits	537	Target Neighborhood Hits	214	Shared Neighborhood Hits	167
SwissProt Accessions	Q92828, Q92829, Q9BWS5	Gene names	CORO2A, IR10, WDR2
Domain Architecture
Description	Coronin-2A (WD repeat-containing protein 2) (IR10).

WDTC1_HUMAN
NC score	0.413400 (rank : 203)	θ value	0.00665767 (rank : 270)
Query Neighborhood Hits	537	Target Neighborhood Hits	299	Shared Neighborhood Hits	204
SwissProt Accessions	Q8N5D0, Q9NV87, Q9UPW4	Gene names	WDTC1, KIAA1037
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

SRC8_HUMAN
NC score	0.413160 (rank : 204)	θ value	3.19293e-05 (rank : 118)
Query Neighborhood Hits	537	Target Neighborhood Hits	269	Shared Neighborhood Hits	184
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

WDTC1_MOUSE
NC score	0.412147 (rank : 205)	θ value	0.00665767 (rank : 271)
Query Neighborhood Hits	537	Target Neighborhood Hits	298	Shared Neighborhood Hits	204
SwissProt Accessions	Q80ZK9	Gene names	Wdtc1
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

RFWD2_HUMAN
NC score	0.411303 (rank : 206)	θ value	6.88961 (rank : 511)
Query Neighborhood Hits	537	Target Neighborhood Hits	518	Shared Neighborhood Hits	198
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

COR1A_MOUSE
NC score	0.411266 (rank : 207)	θ value	0.000602161 (rank : 198)
Query Neighborhood Hits	537	Target Neighborhood Hits	243	Shared Neighborhood Hits	180
SwissProt Accessions	O89053, Q7TMU0, Q9R1Y8, Q9R288	Gene names	Coro1a, Coro1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

RFWD2_MOUSE
NC score	0.410680 (rank : 208)	θ value	6.88961 (rank : 512)
Query Neighborhood Hits	537	Target Neighborhood Hits	535	Shared Neighborhood Hits	199
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

SRC8_MOUSE
NC score	0.409900 (rank : 209)	θ value	3.19293e-05 (rank : 119)
Query Neighborhood Hits	537	Target Neighborhood Hits	292	Shared Neighborhood Hits	183
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

COR1C_HUMAN
NC score	0.409337 (rank : 210)	θ value	0.00020696 (rank : 164)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	176
SwissProt Accessions	Q9ULV4, Q9NSK5	Gene names	CORO1C, CRNN4
Domain Architecture
Description	Coronin-1C (Coronin-3) (hCRNN4).

COR1C_MOUSE
NC score	0.409183 (rank : 211)	θ value	0.000270298 (rank : 172)
Query Neighborhood Hits	537	Target Neighborhood Hits	251	Shared Neighborhood Hits	177
SwissProt Accessions	Q9WUM4, Q8VCQ5	Gene names	Coro1c
Domain Architecture
Description	Coronin-1C (Coronin-3).

VINEX_MOUSE
NC score	0.409147 (rank : 212)	θ value	0.00102713 (rank : 226)
Query Neighborhood Hits	537	Target Neighborhood Hits	286	Shared Neighborhood Hits	195
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

HCLS1_MOUSE
NC score	0.409007 (rank : 213)	θ value	0.00020696 (rank : 168)
Query Neighborhood Hits	537	Target Neighborhood Hits	329	Shared Neighborhood Hits	172
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

VINEX_HUMAN
NC score	0.408768 (rank : 214)	θ value	0.000602161 (rank : 208)
Query Neighborhood Hits	537	Target Neighborhood Hits	270	Shared Neighborhood Hits	191
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

COR2A_MOUSE
NC score	0.407119 (rank : 215)	θ value	5.81887e-07 (rank : 62)
Query Neighborhood Hits	537	Target Neighborhood Hits	204	Shared Neighborhood Hits	156
SwissProt Accessions	Q8C0P5, Q3U6H8, Q8BW42	Gene names	Coro2a
Domain Architecture	No domain graphic available
Description	Coronin-2A.

HCLS1_HUMAN
NC score	0.406967 (rank : 216)	θ value	0.000602161 (rank : 200)
Query Neighborhood Hits	537	Target Neighborhood Hits	358	Shared Neighborhood Hits	175
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

MEP50_MOUSE
NC score	0.406141 (rank : 217)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	537	Target Neighborhood Hits	271	Shared Neighborhood Hits	193
SwissProt Accessions	Q99J09, Q3TFJ1, Q8BSH8, Q9CZY5	Gene names	Wdr77, Mep50
Domain Architecture
Description	Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).

ABI1_HUMAN
NC score	0.406127 (rank : 218)	θ value	6.43352e-06 (rank : 81)
Query Neighborhood Hits	537	Target Neighborhood Hits	257	Shared Neighborhood Hits	176
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

STAM1_MOUSE
NC score	0.404865 (rank : 219)	θ value	3.77169e-06 (rank : 76)
Query Neighborhood Hits	537	Target Neighborhood Hits	273	Shared Neighborhood Hits	190
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC_HUMAN
NC score	0.404455 (rank : 220)	θ value	1.43324e-05 (rank : 98)
Query Neighborhood Hits	537	Target Neighborhood Hits	276	Shared Neighborhood Hits	184
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

WDFY1_HUMAN
NC score	0.404133 (rank : 221)	θ value	0.0961366 (rank : 334)
Query Neighborhood Hits	537	Target Neighborhood Hits	305	Shared Neighborhood Hits	207
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

PPIP1_MOUSE
NC score	0.403789 (rank : 222)	θ value	3.19293e-05 (rank : 115)
Query Neighborhood Hits	537	Target Neighborhood Hits	377	Shared Neighborhood Hits	201
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

STAM1_HUMAN
NC score	0.403497 (rank : 223)	θ value	8.40245e-06 (rank : 86)
Query Neighborhood Hits	537	Target Neighborhood Hits	271	Shared Neighborhood Hits	193
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

BUB3_HUMAN
NC score	0.403246 (rank : 224)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	537	Target Neighborhood Hits	200	Shared Neighborhood Hits	163
SwissProt Accessions	O43684, O43685	Gene names	BUB3
Domain Architecture
Description	Mitotic checkpoint protein BUB3.

MEP50_HUMAN
NC score	0.403132 (rank : 225)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	537	Target Neighborhood Hits	268	Shared Neighborhood Hits	188
SwissProt Accessions	Q9BQA1, Q96GK4, Q9BWY3	Gene names	WDR77, MEP50
Domain Architecture
Description	Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).

ZF106_HUMAN
NC score	0.402917 (rank : 226)	θ value	0.0961366 (rank : 335)
Query Neighborhood Hits	537	Target Neighborhood Hits	470	Shared Neighborhood Hits	178
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

COR1A_HUMAN
NC score	0.402490 (rank : 227)	θ value	0.0431538 (rank : 296)
Query Neighborhood Hits	537	Target Neighborhood Hits	240	Shared Neighborhood Hits	177
SwissProt Accessions	P31146	Gene names	CORO1A, CORO1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

STTP1_HUMAN
NC score	0.401968 (rank : 228)	θ value	0.62314 (rank : 395)
Query Neighborhood Hits	537	Target Neighborhood Hits	232	Shared Neighborhood Hits	200
SwissProt Accessions	Q6IA86, Q53GZ0, Q687Y8, Q8N5C2, Q96GV4, Q96PI7, Q9H9N0, Q9NV81	Gene names	STATIP1
Domain Architecture	No domain graphic available
Description	Stat3-interacting protein (StIP1) (SHINC-2).

PPIP1_HUMAN
NC score	0.400758 (rank : 229)	θ value	4.1701e-05 (rank : 127)
Query Neighborhood Hits	537	Target Neighborhood Hits	389	Shared Neighborhood Hits	202
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

THOC6_HUMAN
NC score	0.400038 (rank : 230)	θ value	1.81305 (rank : 439)
Query Neighborhood Hits	537	Target Neighborhood Hits	223	Shared Neighborhood Hits	181
SwissProt Accessions	Q86W42, Q8NBR1, Q9BTV9	Gene names	THOC6, WDR58
Domain Architecture	No domain graphic available
Description	THO complex subunit 6 homolog (WD repeat protein 58).

STAC_MOUSE
NC score	0.398783 (rank : 231)	θ value	3.19293e-05 (rank : 120)
Query Neighborhood Hits	537	Target Neighborhood Hits	268	Shared Neighborhood Hits	178
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SEC13_MOUSE
NC score	0.398522 (rank : 232)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	537	Target Neighborhood Hits	195	Shared Neighborhood Hits	162
SwissProt Accessions	Q9D1M0, Q99M12, Q9D712	Gene names	Sec13l1
Domain Architecture	No domain graphic available
Description	SEC13-related protein (SEC13-like protein 1).

STAM2_MOUSE
NC score	0.397056 (rank : 233)	θ value	0.000461057 (rank : 195)
Query Neighborhood Hits	537	Target Neighborhood Hits	285	Shared Neighborhood Hits	190
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ZF106_MOUSE
NC score	0.396276 (rank : 234)	θ value	0.47712 (rank : 389)
Query Neighborhood Hits	537	Target Neighborhood Hits	472	Shared Neighborhood Hits	185
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

BUB3_MOUSE
NC score	0.393300 (rank : 235)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	537	Target Neighborhood Hits	199	Shared Neighborhood Hits	163
SwissProt Accessions	Q9WVA3, P97397	Gene names	Bub3
Domain Architecture
Description	Mitotic checkpoint protein BUB3 (WD repeat type I transmembrane protein A72.5).

SEC13_HUMAN
NC score	0.393076 (rank : 236)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	537	Target Neighborhood Hits	199	Shared Neighborhood Hits	164
SwissProt Accessions	P55735, Q9BRM6, Q9BUG7	Gene names	SEC13L1, SEC13R
Domain Architecture	No domain graphic available
Description	SEC13-related protein (SEC13-like protein 1).

FBXW9_HUMAN
NC score	0.391595 (rank : 237)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	537	Target Neighborhood Hits	184	Shared Neighborhood Hits	142
SwissProt Accessions	Q5XUX1, Q9BT89	Gene names	FBXW9, FBW9
Domain Architecture	No domain graphic available
Description	F-box/WD repeat protein 9 (F-box and WD-40 domain protein 9).

COR1B_HUMAN
NC score	0.391573 (rank : 238)	θ value	0.00035302 (rank : 180)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	171
SwissProt Accessions	Q9BR76	Gene names	CORO1B
Domain Architecture
Description	Coronin-1B (Coronin-2).

SCAP_HUMAN
NC score	0.391564 (rank : 239)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	537	Target Neighborhood Hits	368	Shared Neighborhood Hits	175
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

COR1B_MOUSE
NC score	0.390663 (rank : 240)	θ value	0.000461057 (rank : 191)
Query Neighborhood Hits	537	Target Neighborhood Hits	235	Shared Neighborhood Hits	165
SwissProt Accessions	Q9WUM3, Q3UEB1, Q9CVA2	Gene names	Coro1b
Domain Architecture
Description	Coronin-1B (Coronin-2).

WDFY2_HUMAN
NC score	0.387706 (rank : 241)	θ value	4.03905 (rank : 482)
Query Neighborhood Hits	537	Target Neighborhood Hits	332	Shared Neighborhood Hits	217
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
NC score	0.384055 (rank : 242)	θ value	6.88961 (rank : 514)
Query Neighborhood Hits	537	Target Neighborhood Hits	337	Shared Neighborhood Hits	217
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

SH3G2_HUMAN
NC score	0.383869 (rank : 243)	θ value	3.19293e-05 (rank : 117)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	182
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_MOUSE
NC score	0.383069 (rank : 244)	θ value	0.000602161 (rank : 205)
Query Neighborhood Hits	537	Target Neighborhood Hits	236	Shared Neighborhood Hits	180
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRBS1_MOUSE
NC score	0.383010 (rank : 245)	θ value	0.00869519 (rank : 276)
Query Neighborhood Hits	537	Target Neighborhood Hits	409	Shared Neighborhood Hits	202
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM2_HUMAN
NC score	0.382700 (rank : 246)	θ value	0.00175202 (rank : 240)
Query Neighborhood Hits	537	Target Neighborhood Hits	288	Shared Neighborhood Hits	188
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SRBS1_HUMAN
NC score	0.382511 (rank : 247)	θ value	0.0113563 (rank : 281)
Query Neighborhood Hits	537	Target Neighborhood Hits	396	Shared Neighborhood Hits	197
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G2_MOUSE
NC score	0.382271 (rank : 248)	θ value	1.43324e-05 (rank : 97)
Query Neighborhood Hits	537	Target Neighborhood Hits	319	Shared Neighborhood Hits	179
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ARHG7_MOUSE
NC score	0.380272 (rank : 249)	θ value	7.1131e-05 (rank : 132)
Query Neighborhood Hits	537	Target Neighborhood Hits	396	Shared Neighborhood Hits	201
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

WDR6_HUMAN
NC score	0.379517 (rank : 250)	θ value	0.0431538 (rank : 303)
Query Neighborhood Hits	537	Target Neighborhood Hits	193	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NNW5, Q9UF63	Gene names	WDR6
Domain Architecture
Description	WD repeat protein 6.

WDR20_MOUSE
NC score	0.379494 (rank : 251)	θ value	0.0736092 (rank : 320)
Query Neighborhood Hits	537	Target Neighborhood Hits	217	Shared Neighborhood Hits	168
SwissProt Accessions	Q9D5R2	Gene names	Wdr20
Domain Architecture
Description	WD repeat protein 20.

CRKL_HUMAN
NC score	0.378196 (rank : 252)	θ value	0.0148317 (rank : 285)
Query Neighborhood Hits	537	Target Neighborhood Hits	313	Shared Neighborhood Hits	194
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ARHG7_HUMAN
NC score	0.376568 (rank : 253)	θ value	3.19293e-05 (rank : 112)
Query Neighborhood Hits	537	Target Neighborhood Hits	347	Shared Neighborhood Hits	197
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

WDR4_HUMAN
NC score	0.376183 (rank : 254)	θ value	1.09739e-05 (rank : 92)
Query Neighborhood Hits	537	Target Neighborhood Hits	145	Shared Neighborhood Hits	126
SwissProt Accessions	P57081, Q9HCR3	Gene names	WDR4
Domain Architecture
Description	WD repeat protein 4.

NCF1_MOUSE
NC score	0.374229 (rank : 255)	θ value	0.00869519 (rank : 274)
Query Neighborhood Hits	537	Target Neighborhood Hits	198	Shared Neighborhood Hits	164
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_MOUSE
NC score	0.373680 (rank : 256)	θ value	0.000602161 (rank : 201)
Query Neighborhood Hits	537	Target Neighborhood Hits	177	Shared Neighborhood Hits	142
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN2_MOUSE
NC score	0.373673 (rank : 257)	θ value	0.00035302 (rank : 184)
Query Neighborhood Hits	537	Target Neighborhood Hits	382	Shared Neighborhood Hits	196
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.373023 (rank : 258)	θ value	0.000602161 (rank : 202)
Query Neighborhood Hits	537	Target Neighborhood Hits	339	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G3_HUMAN
NC score	0.371942 (rank : 259)	θ value	0.00509761 (rank : 264)
Query Neighborhood Hits	537	Target Neighborhood Hits	222	Shared Neighborhood Hits	174
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

NPHP1_MOUSE
NC score	0.371236 (rank : 260)	θ value	0.000786445 (rank : 211)
Query Neighborhood Hits	537	Target Neighborhood Hits	267	Shared Neighborhood Hits	176
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

THOC6_MOUSE
NC score	0.371047 (rank : 261)	θ value	1.06291 (rank : 417)
Query Neighborhood Hits	537	Target Neighborhood Hits	199	Shared Neighborhood Hits	163
SwissProt Accessions	Q5U4D9	Gene names	Thoc6, Wdr58
Domain Architecture	No domain graphic available
Description	THO complex subunit 6 homolog (WD repeat protein 58).

BOP1_MOUSE
NC score	0.370820 (rank : 262)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	537	Target Neighborhood Hits	267	Shared Neighborhood Hits	192
SwissProt Accessions	P97452, Q3TK87, Q91X31	Gene names	Bop1
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

WDR41_MOUSE
NC score	0.370681 (rank : 263)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	537	Target Neighborhood Hits	209	Shared Neighborhood Hits	165
SwissProt Accessions	Q3UDP0, Q8C4F1, Q8C8K5	Gene names	Wdr41
Domain Architecture	No domain graphic available
Description	WD repeat protein 41.

WDR4_MOUSE
NC score	0.370418 (rank : 264)	θ value	2.88788e-06 (rank : 74)
Query Neighborhood Hits	537	Target Neighborhood Hits	136	Shared Neighborhood Hits	118
SwissProt Accessions	Q9EP82	Gene names	Wdr4
Domain Architecture
Description	WD repeat protein 4.

CRKL_MOUSE
NC score	0.370162 (rank : 265)	θ value	0.0431538 (rank : 297)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	189
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH3G1_HUMAN
NC score	0.369723 (rank : 266)	θ value	0.000270298 (rank : 176)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	182
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STAC3_MOUSE
NC score	0.369496 (rank : 267)	θ value	0.000602161 (rank : 207)
Query Neighborhood Hits	537	Target Neighborhood Hits	232	Shared Neighborhood Hits	154
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCF1_HUMAN
NC score	0.369292 (rank : 268)	θ value	0.0431538 (rank : 301)
Query Neighborhood Hits	537	Target Neighborhood Hits	198	Shared Neighborhood Hits	161
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CRK_MOUSE
NC score	0.369160 (rank : 269)	θ value	0.00020696 (rank : 166)
Query Neighborhood Hits	537	Target Neighborhood Hits	314	Shared Neighborhood Hits	189
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

EMAL2_HUMAN
NC score	0.368960 (rank : 270)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	537	Target Neighborhood Hits	217	Shared Neighborhood Hits	176
SwissProt Accessions	O95834, Q9UG50	Gene names	EML2, EMAP2, EMAPL2
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2).

STAC3_HUMAN
NC score	0.368554 (rank : 271)	θ value	0.000602161 (rank : 206)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	153
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG6_MOUSE
NC score	0.367218 (rank : 272)	θ value	4.1701e-05 (rank : 122)
Query Neighborhood Hits	537	Target Neighborhood Hits	394	Shared Neighborhood Hits	196
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CRK_HUMAN
NC score	0.367012 (rank : 273)	θ value	0.00020696 (rank : 165)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	191
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PACN1_MOUSE
NC score	0.366475 (rank : 274)	θ value	0.000786445 (rank : 213)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	184
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.365457 (rank : 275)	θ value	0.000786445 (rank : 212)
Query Neighborhood Hits	537	Target Neighborhood Hits	320	Shared Neighborhood Hits	185
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SH3G1_MOUSE
NC score	0.364850 (rank : 276)	θ value	0.00298849 (rank : 251)
Query Neighborhood Hits	537	Target Neighborhood Hits	291	Shared Neighborhood Hits	179
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

WDR20_HUMAN
NC score	0.364841 (rank : 277)	θ value	0.365318 (rank : 380)
Query Neighborhood Hits	537	Target Neighborhood Hits	249	Shared Neighborhood Hits	172
SwissProt Accessions	Q8TBZ3, Q8WXX2, Q9UF86	Gene names	WDR20
Domain Architecture
Description	WD repeat protein 20 (DMR protein).

ARHG6_HUMAN
NC score	0.364838 (rank : 278)	θ value	1.09739e-05 (rank : 89)
Query Neighborhood Hits	537	Target Neighborhood Hits	376	Shared Neighborhood Hits	187
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

NUP37_MOUSE
NC score	0.364574 (rank : 279)	θ value	0.125558 (rank : 342)
Query Neighborhood Hits	537	Target Neighborhood Hits	159	Shared Neighborhood Hits	140
SwissProt Accessions	Q9CWU9	Gene names	Nup37
Domain Architecture
Description	Nucleoporin Nup37.

DMWD_MOUSE
NC score	0.363675 (rank : 280)	θ value	0.62314 (rank : 391)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	170
SwissProt Accessions	Q08274	Gene names	Dmwd, Dm9
Domain Architecture
Description	Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (DMR-N9 protein).

TLE4_MOUSE
NC score	0.362129 (rank : 281)	θ value	1.06291 (rank : 421)
Query Neighborhood Hits	537	Target Neighborhood Hits	482	Shared Neighborhood Hits	213
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

TLE4_HUMAN
NC score	0.361666 (rank : 282)	θ value	1.06291 (rank : 420)
Query Neighborhood Hits	537	Target Neighborhood Hits	477	Shared Neighborhood Hits	212
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

EMAL4_HUMAN
NC score	0.359283 (rank : 283)	θ value	1.38821 (rank : 424)
Query Neighborhood Hits	537	Target Neighborhood Hits	306	Shared Neighborhood Hits	197
SwissProt Accessions	Q9HC35	Gene names	EML4, C2orf2, EMAPL4
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120).

BOP1_HUMAN
NC score	0.357750 (rank : 284)	θ value	1.81305 (rank : 433)
Query Neighborhood Hits	537	Target Neighborhood Hits	257	Shared Neighborhood Hits	187
SwissProt Accessions	Q14137, Q969Z6, Q96IS8, Q9BSA7, Q9BVM0	Gene names	BOP1, KIAA0124
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

NCF4_HUMAN
NC score	0.357408 (rank : 285)	θ value	0.000461057 (rank : 192)
Query Neighborhood Hits	537	Target Neighborhood Hits	161	Shared Neighborhood Hits	130
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

TLE3_MOUSE
NC score	0.355330 (rank : 286)	θ value	5.27518 (rank : 497)
Query Neighborhood Hits	537	Target Neighborhood Hits	378	Shared Neighborhood Hits	209
SwissProt Accessions	Q08122, Q923A4	Gene names	Tle3, Esg
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG) (Grg-3).

TLE1_HUMAN
NC score	0.354482 (rank : 287)	θ value	1.06291 (rank : 418)
Query Neighborhood Hits	537	Target Neighborhood Hits	485	Shared Neighborhood Hits	217
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE1_MOUSE
NC score	0.354177 (rank : 288)	θ value	1.06291 (rank : 419)
Query Neighborhood Hits	537	Target Neighborhood Hits	491	Shared Neighborhood Hits	218
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

TLE3_HUMAN
NC score	0.354133 (rank : 289)	θ value	5.27518 (rank : 496)
Query Neighborhood Hits	537	Target Neighborhood Hits	385	Shared Neighborhood Hits	210
SwissProt Accessions	Q04726, Q8IVV6, Q8WVR2, Q9HCM5	Gene names	TLE3, KIAA1547
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG3).

TLE2_HUMAN
NC score	0.353847 (rank : 290)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	537	Target Neighborhood Hits	321	Shared Neighborhood Hits	206
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

ABI3_MOUSE
NC score	0.353714 (rank : 291)	θ value	0.0148317 (rank : 284)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	146
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

TLE2_MOUSE
NC score	0.352364 (rank : 292)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	537	Target Neighborhood Hits	294	Shared Neighborhood Hits	205
SwissProt Accessions	Q9WVB2	Gene names	Tle2, Grg2
Domain Architecture
Description	Transducin-like enhancer protein 2.

PACN3_MOUSE
NC score	0.351782 (rank : 293)	θ value	0.00020696 (rank : 169)
Query Neighborhood Hits	537	Target Neighborhood Hits	380	Shared Neighborhood Hits	179
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

EMAL1_HUMAN
NC score	0.349910 (rank : 294)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	537	Target Neighborhood Hits	214	Shared Neighborhood Hits	177
SwissProt Accessions	O00423	Gene names	EML1, EMAP1, EMAPL, EMAPL1
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1).

ABI3_HUMAN
NC score	0.349047 (rank : 295)	θ value	0.0148317 (rank : 283)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PACN3_HUMAN
NC score	0.348950 (rank : 296)	θ value	0.000461057 (rank : 193)
Query Neighborhood Hits	537	Target Neighborhood Hits	385	Shared Neighborhood Hits	176
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

DNMBP_HUMAN
NC score	0.348780 (rank : 297)	θ value	0.0961366 (rank : 326)
Query Neighborhood Hits	537	Target Neighborhood Hits	413	Shared Neighborhood Hits	207
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NPHP1_HUMAN
NC score	0.345856 (rank : 298)	θ value	0.000121331 (rank : 150)
Query Neighborhood Hits	537	Target Neighborhood Hits	288	Shared Neighborhood Hits	168
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

FBXW4_MOUSE
NC score	0.344809 (rank : 299)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	537	Target Neighborhood Hits	205	Shared Neighborhood Hits	152
SwissProt Accessions	Q9JMJ2, Q9QXW3	Gene names	Fbxw4, Fbw4
Domain Architecture
Description	F-box/WD repeat protein 4 (F-box and WD-40 domain protein 4) (Hagoromo protein).

WDR41_HUMAN
NC score	0.344078 (rank : 300)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	537	Target Neighborhood Hits	208	Shared Neighborhood Hits	168
SwissProt Accessions	Q9HAD4, Q7Z792, Q8IWG3, Q8IXA9, Q8NDA7, Q9NV62	Gene names	WDR41
Domain Architecture	No domain graphic available
Description	WD repeat protein 41.

VAV_HUMAN
NC score	0.344045 (rank : 301)	θ value	7.1131e-05 (rank : 137)
Query Neighborhood Hits	537	Target Neighborhood Hits	452	Shared Neighborhood Hits	194
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.340643 (rank : 302)	θ value	0.00035302 (rank : 187)
Query Neighborhood Hits	537	Target Neighborhood Hits	430	Shared Neighborhood Hits	196
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

DNMBP_MOUSE
NC score	0.339192 (rank : 303)	θ value	0.0961366 (rank : 327)
Query Neighborhood Hits	537	Target Neighborhood Hits	435	Shared Neighborhood Hits	202
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

WDR24_HUMAN
NC score	0.337968 (rank : 304)	θ value	0.813845 (rank : 408)
Query Neighborhood Hits	537	Target Neighborhood Hits	247	Shared Neighborhood Hits	175
SwissProt Accessions	Q96S15, Q96GC7, Q9H0B7	Gene names	WDR24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

WDR75_HUMAN
NC score	0.336728 (rank : 305)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	537	Target Neighborhood Hits	193	Shared Neighborhood Hits	143
SwissProt Accessions	Q8IWA0, Q96J10, Q9H8U8, Q9H9U5, Q9H9V8, Q9UIX2	Gene names	WDR75
Domain Architecture	No domain graphic available
Description	WD repeat protein 75.

IFT80_MOUSE
NC score	0.336668 (rank : 306)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	537	Target Neighborhood Hits	200	Shared Neighborhood Hits	154
SwissProt Accessions	Q8K057	Gene names	Ift80, Wdr56
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 80 homolog (WD repeat protein 56).

WDR7_MOUSE
NC score	0.334429 (rank : 307)	θ value	0.279714 (rank : 367)
Query Neighborhood Hits	537	Target Neighborhood Hits	226	Shared Neighborhood Hits	173
SwissProt Accessions	Q920I9, Q80TY3, Q920J0	Gene names	Wdr7, Kiaa0541, Trag
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG).

IFT80_HUMAN
NC score	0.330429 (rank : 308)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	537	Target Neighborhood Hits	195	Shared Neighborhood Hits	154
SwissProt Accessions	Q9P2H3	Gene names	IFT80, KIAA1374, WDR56
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 80 homolog (WD repeat protein 56).

SEH1L_HUMAN
NC score	0.330053 (rank : 309)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	537	Target Neighborhood Hits	145	Shared Neighborhood Hits	121
SwissProt Accessions	Q96EE3, Q8NFU6, Q96MH3, Q9C069	Gene names	SEH1L, SEC13L, SEH1
Domain Architecture
Description	Nucleoporin SEH1-like (SEC13-like protein).

FBXW4_HUMAN
NC score	0.329413 (rank : 310)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	537	Target Neighborhood Hits	209	Shared Neighborhood Hits	154
SwissProt Accessions	P57775, Q5SVS1, Q96IM6	Gene names	FBXW4, FBW4, SHFM3
Domain Architecture
Description	F-box/WD repeat protein 4 (F-box and WD-40 domain protein 4) (Dactylin).

OSTF1_HUMAN
NC score	0.327394 (rank : 311)	θ value	0.00102713 (rank : 221)
Query Neighborhood Hits	537	Target Neighborhood Hits	466	Shared Neighborhood Hits	190
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ITSN2_HUMAN
NC score	0.326941 (rank : 312)	θ value	4.76016e-09 (rank : 28)
Query Neighborhood Hits	537	Target Neighborhood Hits	1173	Shared Neighborhood Hits	243
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

WDR7_HUMAN
NC score	0.326489 (rank : 313)	θ value	0.47712 (rank : 388)
Query Neighborhood Hits	537	Target Neighborhood Hits	244	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

PLCG2_HUMAN
NC score	0.324446 (rank : 314)	θ value	1.80886e-08 (rank : 36)
Query Neighborhood Hits	537	Target Neighborhood Hits	280	Shared Neighborhood Hits	162
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

DBNL_HUMAN
NC score	0.323776 (rank : 315)	θ value	0.0736092 (rank : 315)
Query Neighborhood Hits	537	Target Neighborhood Hits	244	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
NC score	0.319776 (rank : 316)	θ value	0.0736092 (rank : 316)
Query Neighborhood Hits	537	Target Neighborhood Hits	306	Shared Neighborhood Hits	156
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

VAV2_HUMAN
NC score	0.319448 (rank : 317)	θ value	0.00102713 (rank : 225)
Query Neighborhood Hits	537	Target Neighborhood Hits	453	Shared Neighborhood Hits	191
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

LASP1_HUMAN
NC score	0.318648 (rank : 318)	θ value	0.0113563 (rank : 279)
Query Neighborhood Hits	537	Target Neighborhood Hits	293	Shared Neighborhood Hits	153
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

OSTF1_MOUSE
NC score	0.318185 (rank : 319)	θ value	0.00175202 (rank : 234)
Query Neighborhood Hits	537	Target Neighborhood Hits	467	Shared Neighborhood Hits	190
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

VAV2_MOUSE
NC score	0.317400 (rank : 320)	θ value	0.00228821 (rank : 244)
Query Neighborhood Hits	537	Target Neighborhood Hits	456	Shared Neighborhood Hits	190
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

LASP1_MOUSE
NC score	0.316959 (rank : 321)	θ value	0.0113563 (rank : 280)
Query Neighborhood Hits	537	Target Neighborhood Hits	297	Shared Neighborhood Hits	153
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NUP37_HUMAN
NC score	0.314875 (rank : 322)	θ value	2.36792 (rank : 454)
Query Neighborhood Hits	537	Target Neighborhood Hits	153	Shared Neighborhood Hits	137
SwissProt Accessions	Q8NFH4, Q9H644	Gene names	NUP37
Domain Architecture
Description	Nucleoporin Nup37 (p37).

PLCG1_MOUSE
NC score	0.314031 (rank : 323)	θ value	1.09739e-05 (rank : 91)
Query Neighborhood Hits	537	Target Neighborhood Hits	314	Shared Neighborhood Hits	168
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV3_HUMAN
NC score	0.310947 (rank : 324)	θ value	0.00228821 (rank : 245)
Query Neighborhood Hits	537	Target Neighborhood Hits	398	Shared Neighborhood Hits	187
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

DDB2_HUMAN
NC score	0.310693 (rank : 325)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	537	Target Neighborhood Hits	175	Shared Neighborhood Hits	135
SwissProt Accessions	Q92466, Q76E54, Q76E55, Q76E56, Q76E57	Gene names	DDB2
Domain Architecture
Description	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) (DDB p48 subunit) (DDBb) (UV-damaged DNA-binding protein 2) (UV-DDB 2).

CT032_HUMAN
NC score	0.310153 (rank : 326)	θ value	0.00298849 (rank : 247)
Query Neighborhood Hits	537	Target Neighborhood Hits	235	Shared Neighborhood Hits	150
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

ITSN2_MOUSE
NC score	0.309279 (rank : 327)	θ value	3.08544e-08 (rank : 38)
Query Neighborhood Hits	537	Target Neighborhood Hits	1371	Shared Neighborhood Hits	242
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DDB2_MOUSE
NC score	0.306734 (rank : 328)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	537	Target Neighborhood Hits	175	Shared Neighborhood Hits	141
SwissProt Accessions	Q99J79	Gene names	Ddb2
Domain Architecture	No domain graphic available
Description	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2).

VAV3_MOUSE
NC score	0.306008 (rank : 329)	θ value	0.00390308 (rank : 257)
Query Neighborhood Hits	537	Target Neighborhood Hits	404	Shared Neighborhood Hits	187
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PLCG1_HUMAN
NC score	0.305649 (rank : 330)	θ value	1.43324e-05 (rank : 96)
Query Neighborhood Hits	537	Target Neighborhood Hits	293	Shared Neighborhood Hits	161
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ITSN1_HUMAN
NC score	0.303179 (rank : 331)	θ value	1.06045e-08 (rank : 31)
Query Neighborhood Hits	537	Target Neighborhood Hits	1757	Shared Neighborhood Hits	255
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.302708 (rank : 332)	θ value	1.80886e-08 (rank : 35)
Query Neighborhood Hits	537	Target Neighborhood Hits	1669	Shared Neighborhood Hits	250
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

EFS_MOUSE
NC score	0.300231 (rank : 333)	θ value	0.00102713 (rank : 219)
Query Neighborhood Hits	537	Target Neighborhood Hits	389	Shared Neighborhood Hits	156
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

BCAR1_MOUSE
NC score	0.299402 (rank : 334)	θ value	0.00102713 (rank : 216)
Query Neighborhood Hits	537	Target Neighborhood Hits	438	Shared Neighborhood Hits	168
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EFS_HUMAN
NC score	0.292308 (rank : 335)	θ value	0.00102713 (rank : 218)
Query Neighborhood Hits	537	Target Neighborhood Hits	348	Shared Neighborhood Hits	152
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ARHG4_HUMAN
NC score	0.292220 (rank : 336)	θ value	0.000270298 (rank : 171)
Query Neighborhood Hits	537	Target Neighborhood Hits	242	Shared Neighborhood Hits	164
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NEBL_HUMAN
NC score	0.290039 (rank : 337)	θ value	0.00665767 (rank : 266)
Query Neighborhood Hits	537	Target Neighborhood Hits	457	Shared Neighborhood Hits	171
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

BCAR1_HUMAN
NC score	0.289683 (rank : 338)	θ value	0.00035302 (rank : 178)
Query Neighborhood Hits	537	Target Neighborhood Hits	554	Shared Neighborhood Hits	169
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NUP43_MOUSE
NC score	0.286637 (rank : 339)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	537	Target Neighborhood Hits	193	Shared Neighborhood Hits	148
SwissProt Accessions	P59235	Gene names	Nup43
Domain Architecture
Description	Nucleoporin Nup43.

UTP18_HUMAN
NC score	0.283516 (rank : 340)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y5J1, Q9H4N6	Gene names	UTP18, WDR50
Domain Architecture
Description	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat protein 50).

NUP43_HUMAN
NC score	0.283394 (rank : 341)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	537	Target Neighborhood Hits	198	Shared Neighborhood Hits	152
SwissProt Accessions	Q8NFH3, Q9H8S0	Gene names	NUP43
Domain Architecture
Description	Nucleoporin Nup43 (p42).

ARHG9_MOUSE
NC score	0.282320 (rank : 342)	θ value	4.1701e-05 (rank : 124)
Query Neighborhood Hits	537	Target Neighborhood Hits	234	Shared Neighborhood Hits	157
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

WD21C_HUMAN
NC score	0.282041 (rank : 343)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	124
SwissProt Accessions	Q8NA75	Gene names	WDR21C
Domain Architecture	No domain graphic available
Description	WD repeat protein 21C.

WDR81_MOUSE
NC score	0.281920 (rank : 344)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	156
SwissProt Accessions	Q5ND34, Q3TA90, Q3TUS9, Q6KAR1	Gene names	Wdr81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

ARHG9_HUMAN
NC score	0.281919 (rank : 345)	θ value	4.1701e-05 (rank : 123)
Query Neighborhood Hits	537	Target Neighborhood Hits	235	Shared Neighborhood Hits	156
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

DMXL2_HUMAN
NC score	0.281879 (rank : 346)	θ value	0.21417 (rank : 356)
Query Neighborhood Hits	537	Target Neighborhood Hits	374	Shared Neighborhood Hits	178
SwissProt Accessions	Q8TDJ6, O94938	Gene names	DMXL2, KIAA0856
Domain Architecture	No domain graphic available
Description	Protein DmX-like 2 (Rabconnectin-3).

UTP18_MOUSE
NC score	0.273914 (rank : 347)	θ value	0.0563607 (rank : 311)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	98
SwissProt Accessions	Q5SSI6	Gene names	Utp18, Wdr50
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat protein 50).

ES8L3_MOUSE
NC score	0.264544 (rank : 348)	θ value	0.0736092 (rank : 317)
Query Neighborhood Hits	537	Target Neighborhood Hits	168	Shared Neighborhood Hits	145
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

CASL_MOUSE
NC score	0.262345 (rank : 349)	θ value	0.163984 (rank : 346)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	151
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

ANM2_HUMAN
NC score	0.260455 (rank : 350)	θ value	0.000602161 (rank : 197)
Query Neighborhood Hits	537	Target Neighborhood Hits	175	Shared Neighborhood Hits	148
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

IASPP_HUMAN
NC score	0.260335 (rank : 351)	θ value	9.29e-05 (rank : 141)
Query Neighborhood Hits	537	Target Neighborhood Hits	688	Shared Neighborhood Hits	161
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NEBU_HUMAN
NC score	0.260280 (rank : 352)	θ value	0.00665767 (rank : 267)
Query Neighborhood Hits	537	Target Neighborhood Hits	420	Shared Neighborhood Hits	174
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

CASL_HUMAN
NC score	0.260049 (rank : 353)	θ value	0.163984 (rank : 345)
Query Neighborhood Hits	537	Target Neighborhood Hits	259	Shared Neighborhood Hits	148
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CIR1A_HUMAN
NC score	0.257234 (rank : 354)	θ value	5.27518 (rank : 484)
Query Neighborhood Hits	537	Target Neighborhood Hits	158	Shared Neighborhood Hits	125
SwissProt Accessions	Q969X6, Q8NCD9, Q8TF14, Q96SP0, Q96SR9, Q96SZ9, Q96T13, Q9BWK6	Gene names	CIRH1A, KIAA1988
Domain Architecture
Description	Cirhin.

PREB_HUMAN
NC score	0.256784 (rank : 355)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	537	Target Neighborhood Hits	163	Shared Neighborhood Hits	134
SwissProt Accessions	Q9HCU5, Q9UH94	Gene names	PREB, SEC12
Domain Architecture
Description	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12).

WDR81_HUMAN
NC score	0.256782 (rank : 356)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	537	Target Neighborhood Hits	205	Shared Neighborhood Hits	140
SwissProt Accessions	Q562E7, Q24JP6, Q8N277, Q8N3F3	Gene names	WDR81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

TSCC1_MOUSE
NC score	0.254416 (rank : 357)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	537	Target Neighborhood Hits	160	Shared Neighborhood Hits	117
SwissProt Accessions	Q8K0G5	Gene names	Tssc1
Domain Architecture	No domain graphic available
Description	Protein TSSC1.

ANM2_MOUSE
NC score	0.254227 (rank : 358)	θ value	0.000158464 (rank : 156)
Query Neighborhood Hits	537	Target Neighborhood Hits	175	Shared Neighborhood Hits	143
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CIR1A_MOUSE
NC score	0.253868 (rank : 359)	θ value	1.06291 (rank : 410)
Query Neighborhood Hits	537	Target Neighborhood Hits	155	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R2N2, Q62306, Q69Z48, Q6NVG9, Q8VEL5	Gene names	Cirh1a, Kiaa1988, Tex292
Domain Architecture	No domain graphic available
Description	Cirhin (Testis-expressed gene 292 protein).

TSSC1_HUMAN
NC score	0.250700 (rank : 360)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	121
SwissProt Accessions	Q53HC9, O43179, Q53S19, Q53SG2	Gene names	TSSC1
Domain Architecture	No domain graphic available
Description	Protein TSSC1 (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) (Tumor-suppressing STF cDNA 1 protein).

FBXW5_MOUSE
NC score	0.250609 (rank : 361)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	537	Target Neighborhood Hits	159	Shared Neighborhood Hits	123
SwissProt Accessions	Q9QXW2	Gene names	Fbxw5, Fbw5
Domain Architecture
Description	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5).

DMXL1_MOUSE
NC score	0.250274 (rank : 362)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	537	Target Neighborhood Hits	257	Shared Neighborhood Hits	171
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

PREB_MOUSE
NC score	0.249644 (rank : 363)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	129
SwissProt Accessions	Q9WUQ2, Q9QZ99	Gene names	Preb, Sec12
Domain Architecture
Description	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12).

ES8L3_HUMAN
NC score	0.247445 (rank : 364)	θ value	0.813845 (rank : 401)
Query Neighborhood Hits	537	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L2_HUMAN
NC score	0.247402 (rank : 365)	θ value	0.00228821 (rank : 243)
Query Neighborhood Hits	537	Target Neighborhood Hits	193	Shared Neighborhood Hits	129
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

TLE6_MOUSE
NC score	0.247068 (rank : 366)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	537	Target Neighborhood Hits	178	Shared Neighborhood Hits	125
SwissProt Accessions	Q9WVB3	Gene names	Tle6, Grg6
Domain Architecture
Description	Transducin-like enhancer protein 6 (Groucho-related protein 6).

AAAS_HUMAN
NC score	0.245970 (rank : 367)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	537	Target Neighborhood Hits	154	Shared Neighborhood Hits	125
SwissProt Accessions	Q9NRG9, Q9NWI6, Q9UG19	Gene names	AAAS, ADRACALA
Domain Architecture
Description	Aladin (Adracalin).

RUSC1_HUMAN
NC score	0.244672 (rank : 368)	θ value	0.00665767 (rank : 268)
Query Neighborhood Hits	537	Target Neighborhood Hits	226	Shared Neighborhood Hits	134
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ES8L2_MOUSE
NC score	0.243423 (rank : 369)	θ value	0.00175202 (rank : 232)
Query Neighborhood Hits	537	Target Neighborhood Hits	169	Shared Neighborhood Hits	127
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

WDR72_HUMAN
NC score	0.242973 (rank : 370)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	537	Target Neighborhood Hits	167	Shared Neighborhood Hits	125
SwissProt Accessions	Q3MJ13, Q7Z3I3, Q8N8X2	Gene names	WDR72
Domain Architecture	No domain graphic available
Description	WD repeat protein 72.

LYST_HUMAN
NC score	0.242423 (rank : 371)	θ value	0.163984 (rank : 349)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	145
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

RIMB2_HUMAN
NC score	0.241943 (rank : 372)	θ value	0.00175202 (rank : 238)
Query Neighborhood Hits	537	Target Neighborhood Hits	263	Shared Neighborhood Hits	113
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

IASPP_MOUSE
NC score	0.239837 (rank : 373)	θ value	4.1701e-05 (rank : 126)
Query Neighborhood Hits	537	Target Neighborhood Hits	1024	Shared Neighborhood Hits	174
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

RIMB2_MOUSE
NC score	0.239686 (rank : 374)	θ value	0.000786445 (rank : 214)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	107
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

KI21B_HUMAN
NC score	0.237328 (rank : 375)	θ value	0.0431538 (rank : 300)
Query Neighborhood Hits	537	Target Neighborhood Hits	1017	Shared Neighborhood Hits	238
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

ASPP1_HUMAN
NC score	0.236763 (rank : 376)	θ value	3.19293e-05 (rank : 113)
Query Neighborhood Hits	537	Target Neighborhood Hits	956	Shared Neighborhood Hits	186
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
NC score	0.235806 (rank : 377)	θ value	2.21117e-06 (rank : 70)
Query Neighborhood Hits	537	Target Neighborhood Hits	1244	Shared Neighborhood Hits	197
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

RHG04_HUMAN
NC score	0.235133 (rank : 378)	θ value	0.00134147 (rank : 230)
Query Neighborhood Hits	537	Target Neighborhood Hits	307	Shared Neighborhood Hits	164
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

FBXW5_HUMAN
NC score	0.235126 (rank : 379)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	121
SwissProt Accessions	Q969U6, Q5SPZ8, Q5SPZ9, Q5SQ02, Q5SQ03, Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, Q9H6A8, Q9HBQ6, Q9NSZ3	Gene names	FBXW5, FBW5
Domain Architecture
Description	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5).

KI21B_MOUSE
NC score	0.234533 (rank : 380)	θ value	0.365318 (rank : 370)
Query Neighborhood Hits	537	Target Neighborhood Hits	997	Shared Neighborhood Hits	235
SwissProt Accessions	Q9QXL1, P97424	Gene names	Kif21b, Kif6
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B (Kinesin-like protein KIF6).

ARHG4_MOUSE
NC score	0.232484 (rank : 381)	θ value	0.0113563 (rank : 277)
Query Neighborhood Hits	537	Target Neighborhood Hits	185	Shared Neighborhood Hits	118
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ES8L1_HUMAN
NC score	0.230988 (rank : 382)	θ value	0.00390308 (rank : 255)
Query Neighborhood Hits	537	Target Neighborhood Hits	162	Shared Neighborhood Hits	107
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
NC score	0.229017 (rank : 383)	θ value	0.00035302 (rank : 181)
Query Neighborhood Hits	537	Target Neighborhood Hits	143	Shared Neighborhood Hits	97
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

WDFY3_HUMAN
NC score	0.228509 (rank : 384)	θ value	0.365318 (rank : 379)
Query Neighborhood Hits	537	Target Neighborhood Hits	348	Shared Neighborhood Hits	168
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

LYST_MOUSE
NC score	0.227754 (rank : 385)	θ value	0.163984 (rank : 350)
Query Neighborhood Hits	537	Target Neighborhood Hits	286	Shared Neighborhood Hits	146
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

PEX13_HUMAN
NC score	0.226217 (rank : 386)	θ value	4.03905 (rank : 477)
Query Neighborhood Hits	537	Target Neighborhood Hits	128	Shared Neighborhood Hits	113
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

WD21A_HUMAN
NC score	0.223789 (rank : 387)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	537	Target Neighborhood Hits	136	Shared Neighborhood Hits	113
SwissProt Accessions	Q8WV16, Q86U31, Q96K22, Q9Y4P5	Gene names	WDR21A, WDR21
Domain Architecture
Description	WD repeat protein 21A.

WDFY3_MOUSE
NC score	0.222652 (rank : 388)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	537	Target Neighborhood Hits	332	Shared Neighborhood Hits	168
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

PEX13_MOUSE
NC score	0.222245 (rank : 389)	θ value	4.03905 (rank : 478)
Query Neighborhood Hits	537	Target Neighborhood Hits	126	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SLAP2_MOUSE
NC score	0.218541 (rank : 390)	θ value	1.81305 (rank : 438)
Query Neighborhood Hits	537	Target Neighborhood Hits	136	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

DMXL1_HUMAN
NC score	0.218538 (rank : 391)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	537	Target Neighborhood Hits	259	Shared Neighborhood Hits	167
SwissProt Accessions	Q9Y485	Gene names	DMXL1, XL1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

SNX18_MOUSE
NC score	0.218128 (rank : 392)	θ value	0.813845 (rank : 406)
Query Neighborhood Hits	537	Target Neighborhood Hits	198	Shared Neighborhood Hits	128
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

EPS8_MOUSE
NC score	0.215678 (rank : 393)	θ value	0.0193708 (rank : 289)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	128
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

SLAP2_HUMAN
NC score	0.215579 (rank : 394)	θ value	3.0926 (rank : 466)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

KI21A_HUMAN
NC score	0.214799 (rank : 395)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	537	Target Neighborhood Hits	1543	Shared Neighborhood Hits	244
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

RUSC1_MOUSE
NC score	0.213456 (rank : 396)	θ value	0.279714 (rank : 364)
Query Neighborhood Hits	537	Target Neighborhood Hits	206	Shared Neighborhood Hits	127
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

WDR67_MOUSE
NC score	0.212695 (rank : 397)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	537	Target Neighborhood Hits	476	Shared Neighborhood Hits	129
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

SNX18_HUMAN
NC score	0.212319 (rank : 398)	θ value	0.813845 (rank : 405)
Query Neighborhood Hits	537	Target Neighborhood Hits	207	Shared Neighborhood Hits	129
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

KI21A_MOUSE
NC score	0.210908 (rank : 399)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	537	Target Neighborhood Hits	1317	Shared Neighborhood Hits	232
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

NOXO1_MOUSE
NC score	0.209789 (rank : 400)	θ value	8.99809 (rank : 530)
Query Neighborhood Hits	537	Target Neighborhood Hits	114	Shared Neighborhood Hits	102
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

FBXW8_HUMAN
NC score	0.209462 (rank : 401)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	537	Target Neighborhood Hits	192	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N3Y1, Q9UK95	Gene names	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8) (F-box only protein 29).

EPS8_HUMAN
NC score	0.208560 (rank : 402)	θ value	0.0431538 (rank : 298)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	112
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

AAAS_MOUSE
NC score	0.206127 (rank : 403)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	537	Target Neighborhood Hits	144	Shared Neighborhood Hits	115
SwissProt Accessions	P58742, Q544M6	Gene names	Aaas
Domain Architecture
Description	Aladin (Adracalin).

SRGP2_MOUSE
NC score	0.205768 (rank : 404)	θ value	0.125558 (rank : 344)
Query Neighborhood Hits	537	Target Neighborhood Hits	324	Shared Neighborhood Hits	156
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.201971 (rank : 405)	θ value	0.163984 (rank : 351)
Query Neighborhood Hits	537	Target Neighborhood Hits	331	Shared Neighborhood Hits	153
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SLAP1_HUMAN
NC score	0.201686 (rank : 406)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	537	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.199904 (rank : 407)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	537	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

DC1I2_MOUSE
NC score	0.196781 (rank : 408)	θ value	0.0961366 (rank : 324)
Query Neighborhood Hits	537	Target Neighborhood Hits	209	Shared Neighborhood Hits	118
SwissProt Accessions	O88487, Q3TGH7	Gene names	Dync1i2, Dnci2, Dncic2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

FNBP2_HUMAN
NC score	0.196775 (rank : 409)	θ value	0.0113563 (rank : 278)
Query Neighborhood Hits	537	Target Neighborhood Hits	432	Shared Neighborhood Hits	154
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ARC1B_HUMAN
NC score	0.196247 (rank : 410)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	537	Target Neighborhood Hits	148	Shared Neighborhood Hits	125
SwissProt Accessions	O15143, Q9BU00	Gene names	ARPC1B, ARC41
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1B (ARP2/3 complex 41 kDa subunit) (p41-ARC).

SRGP1_HUMAN
NC score	0.194679 (rank : 411)	θ value	0.0961366 (rank : 331)
Query Neighborhood Hits	537	Target Neighborhood Hits	390	Shared Neighborhood Hits	148
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

NBEAL_HUMAN
NC score	0.194489 (rank : 412)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	537	Target Neighborhood Hits	200	Shared Neighborhood Hits	143
SwissProt Accessions	Q6ZS30, Q6Y876, Q6ZQY5, Q96Q30	Gene names	NBEAL1, ALS2CR17
Domain Architecture	No domain graphic available
Description	Neurobeachin-like 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein).

ASPP2_HUMAN
NC score	0.193449 (rank : 413)	θ value	0.00175202 (rank : 231)
Query Neighborhood Hits	537	Target Neighborhood Hits	1156	Shared Neighborhood Hits	173
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

DC1I2_HUMAN
NC score	0.192686 (rank : 414)	θ value	0.0961366 (rank : 323)
Query Neighborhood Hits	537	Target Neighborhood Hits	201	Shared Neighborhood Hits	117
SwissProt Accessions	Q13409, Q96NG7, Q96S87, Q9BXZ5, Q9NT58	Gene names	DYNC1I2, DNCI2, DNCIC2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

DDEF1_MOUSE
NC score	0.189219 (rank : 415)	θ value	0.00390308 (rank : 254)
Query Neighborhood Hits	537	Target Neighborhood Hits	592	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

WDR85_HUMAN
NC score	0.189147 (rank : 416)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	537	Target Neighborhood Hits	134	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BTV6, Q96AB7	Gene names	WDR85, C9orf112
Domain Architecture	No domain graphic available
Description	WD repeat protein 85.

SPTA2_HUMAN
NC score	0.188841 (rank : 417)	θ value	0.00035302 (rank : 186)
Query Neighborhood Hits	537	Target Neighborhood Hits	888	Shared Neighborhood Hits	201
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

WDR46_HUMAN
NC score	0.184769 (rank : 418)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	537	Target Neighborhood Hits	147	Shared Neighborhood Hits	100
SwissProt Accessions	O15213, Q5STK5	Gene names	WDR46, BING4, C6orf11
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

WDR67_HUMAN
NC score	0.183121 (rank : 419)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	537	Target Neighborhood Hits	782	Shared Neighborhood Hits	147
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

MYO1F_HUMAN
NC score	0.182939 (rank : 420)	θ value	5.44631e-05 (rank : 129)
Query Neighborhood Hits	537	Target Neighborhood Hits	275	Shared Neighborhood Hits	183
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.182674 (rank : 421)	θ value	3.19293e-05 (rank : 114)
Query Neighborhood Hits	537	Target Neighborhood Hits	262	Shared Neighborhood Hits	181
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

DNAI1_HUMAN
NC score	0.181558 (rank : 422)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	537	Target Neighborhood Hits	148	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UI46, Q9UEZ8	Gene names	DNAI1
Domain Architecture
Description	Dynein intermediate chain 1, axonemal (Axonemal dynein intermediate chain 1).

DDEF2_HUMAN
NC score	0.181434 (rank : 423)	θ value	0.00020696 (rank : 167)
Query Neighborhood Hits	537	Target Neighborhood Hits	599	Shared Neighborhood Hits	157
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

FBXW8_MOUSE
NC score	0.181252 (rank : 424)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	537	Target Neighborhood Hits	162	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BIA4, Q8BI62, Q8BI75, Q8BI76, Q8CID8, Q921Z1	Gene names	Fbxw8
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8).

DDEF2_MOUSE
NC score	0.180317 (rank : 425)	θ value	0.00102713 (rank : 217)
Query Neighborhood Hits	537	Target Neighborhood Hits	625	Shared Neighborhood Hits	157
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

WDR68_HUMAN
NC score	0.179948 (rank : 426)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	537	Target Neighborhood Hits	121	Shared Neighborhood Hits	102
SwissProt Accessions	P61962, O15491, Q9DAE4	Gene names	WDR68, HAN11
Domain Architecture
Description	WD repeat protein 68 (WD repeat protein An11 homolog).

WDR68_MOUSE
NC score	0.179948 (rank : 427)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	537	Target Neighborhood Hits	121	Shared Neighborhood Hits	102
SwissProt Accessions	P61963, O15491, Q3TMV9, Q9DAE4	Gene names	Wdr68, Han11
Domain Architecture
Description	WD repeat protein 68 (WD repeat protein An11 homolog).

ARC1B_MOUSE
NC score	0.179735 (rank : 428)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	537	Target Neighborhood Hits	133	Shared Neighborhood Hits	112
SwissProt Accessions	Q9WV32	Gene names	Arpc1b
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1B (ARP2/3 complex 41 kDa subunit) (p41-ARC).

SPTA1_MOUSE
NC score	0.178806 (rank : 429)	θ value	0.00175202 (rank : 239)
Query Neighborhood Hits	537	Target Neighborhood Hits	675	Shared Neighborhood Hits	189
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

MYO1E_HUMAN
NC score	0.175217 (rank : 430)	θ value	7.1131e-05 (rank : 135)
Query Neighborhood Hits	537	Target Neighborhood Hits	293	Shared Neighborhood Hits	177
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SPTA1_HUMAN
NC score	0.173060 (rank : 431)	θ value	0.000786445 (rank : 215)
Query Neighborhood Hits	537	Target Neighborhood Hits	748	Shared Neighborhood Hits	194
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

FYN_MOUSE
NC score	0.173005 (rank : 432)	θ value	2.21117e-06 (rank : 72)
Query Neighborhood Hits	537	Target Neighborhood Hits	1073	Shared Neighborhood Hits	195
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

DNAI2_HUMAN
NC score	0.171034 (rank : 433)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	104
SwissProt Accessions	Q9GZS0, Q9H179, Q9NT53	Gene names	DNAI2
Domain Architecture
Description	Dynein intermediate chain 2, axonemal (Axonemal dynein intermediate chain 2).

NGEF_MOUSE
NC score	0.170147 (rank : 434)	θ value	0.00390308 (rank : 256)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
NC score	0.170104 (rank : 435)	θ value	0.00298849 (rank : 250)
Query Neighborhood Hits	537	Target Neighborhood Hits	166	Shared Neighborhood Hits	81
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FYN_HUMAN
NC score	0.170058 (rank : 436)	θ value	2.21117e-06 (rank : 71)
Query Neighborhood Hits	537	Target Neighborhood Hits	1078	Shared Neighborhood Hits	195
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FGR_HUMAN
NC score	0.170010 (rank : 437)	θ value	0.000158464 (rank : 159)
Query Neighborhood Hits	537	Target Neighborhood Hits	1067	Shared Neighborhood Hits	187
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_HUMAN
NC score	0.169839 (rank : 438)	θ value	3.77169e-06 (rank : 78)
Query Neighborhood Hits	537	Target Neighborhood Hits	1059	Shared Neighborhood Hits	192
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.169527 (rank : 439)	θ value	8.40245e-06 (rank : 88)
Query Neighborhood Hits	537	Target Neighborhood Hits	1052	Shared Neighborhood Hits	192
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
NC score	0.169420 (rank : 440)	θ value	1.43324e-05 (rank : 95)
Query Neighborhood Hits	537	Target Neighborhood Hits	1069	Shared Neighborhood Hits	189
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

NOXO1_HUMAN
NC score	0.167413 (rank : 441)	θ value	5.27518 (rank : 491)
Query Neighborhood Hits	537	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

ARHG5_HUMAN
NC score	0.166417 (rank : 442)	θ value	0.125558 (rank : 337)
Query Neighborhood Hits	537	Target Neighborhood Hits	172	Shared Neighborhood Hits	91
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARC1A_HUMAN
NC score	0.165766 (rank : 443)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	537	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	Q92747, Q7Z5U8, Q86WU5, Q8IXQ0	Gene names	ARPC1A, SOP2L
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein).

SRC_HUMAN
NC score	0.165260 (rank : 444)	θ value	2.44474e-05 (rank : 110)
Query Neighborhood Hits	537	Target Neighborhood Hits	1058	Shared Neighborhood Hits	194
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

RPTOR_HUMAN
NC score	0.165013 (rank : 445)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	537	Target Neighborhood Hits	121	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

ARC1A_MOUSE
NC score	0.164348 (rank : 446)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	537	Target Neighborhood Hits	120	Shared Neighborhood Hits	102
SwissProt Accessions	Q9R0Q6, Q3UL75	Gene names	Arpc1a, Sid329
Domain Architecture	No domain graphic available
Description	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) (Sid 329).

WDR46_MOUSE
NC score	0.164074 (rank : 447)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	537	Target Neighborhood Hits	243	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

SPN90_HUMAN
NC score	0.163672 (rank : 448)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

P85A_MOUSE
NC score	0.160015 (rank : 449)	θ value	0.279714 (rank : 363)
Query Neighborhood Hits	537	Target Neighborhood Hits	435	Shared Neighborhood Hits	125
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BTK_HUMAN
NC score	0.156398 (rank : 450)	θ value	1.43324e-05 (rank : 94)
Query Neighborhood Hits	537	Target Neighborhood Hits	1026	Shared Neighborhood Hits	189
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

RHG26_HUMAN
NC score	0.155516 (rank : 451)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	537	Target Neighborhood Hits	281	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

P85A_HUMAN
NC score	0.155240 (rank : 452)	θ value	0.21417 (rank : 360)
Query Neighborhood Hits	537	Target Neighborhood Hits	479	Shared Neighborhood Hits	123
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

HCK_MOUSE
NC score	0.155230 (rank : 453)	θ value	0.000270298 (rank : 173)
Query Neighborhood Hits	537	Target Neighborhood Hits	1029	Shared Neighborhood Hits	185
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCK_HUMAN
NC score	0.154997 (rank : 454)	θ value	0.000158464 (rank : 162)
Query Neighborhood Hits	537	Target Neighborhood Hits	1035	Shared Neighborhood Hits	187
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

TCGAP_MOUSE
NC score	0.154052 (rank : 455)	θ value	0.0563607 (rank : 310)
Query Neighborhood Hits	537	Target Neighborhood Hits	409	Shared Neighborhood Hits	129
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RPTOR_MOUSE
NC score	0.153589 (rank : 456)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	537	Target Neighborhood Hits	129	Shared Neighborhood Hits	84
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

BTK_MOUSE
NC score	0.151517 (rank : 457)	θ value	5.44631e-05 (rank : 128)
Query Neighborhood Hits	537	Target Neighborhood Hits	1017	Shared Neighborhood Hits	179
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SRC_MOUSE
NC score	0.150440 (rank : 458)	θ value	0.00102713 (rank : 224)
Query Neighborhood Hits	537	Target Neighborhood Hits	1033	Shared Neighborhood Hits	173
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

DC1I1_HUMAN
NC score	0.148853 (rank : 459)	θ value	4.03905 (rank : 473)
Query Neighborhood Hits	537	Target Neighborhood Hits	183	Shared Neighborhood Hits	95
SwissProt Accessions	O14576, Q9Y2X1	Gene names	DYNC1I1, DNCI1, DNCIC1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

M3KL4_HUMAN
NC score	0.148538 (rank : 460)	θ value	8.40245e-06 (rank : 84)
Query Neighborhood Hits	537	Target Neighborhood Hits	1087	Shared Neighborhood Hits	185
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

BLK_HUMAN
NC score	0.146199 (rank : 461)	θ value	2.44474e-05 (rank : 108)
Query Neighborhood Hits	537	Target Neighborhood Hits	994	Shared Neighborhood Hits	156
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

TLE6_HUMAN
NC score	0.145975 (rank : 462)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	537	Target Neighborhood Hits	120	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H808	Gene names	TLE6
Domain Architecture	No domain graphic available
Description	Transducin-like enhancer protein 6.

LYN_MOUSE
NC score	0.143424 (rank : 463)	θ value	0.00298849 (rank : 248)
Query Neighborhood Hits	537	Target Neighborhood Hits	1023	Shared Neighborhood Hits	168
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.143412 (rank : 464)	θ value	0.00869519 (rank : 273)
Query Neighborhood Hits	537	Target Neighborhood Hits	1022	Shared Neighborhood Hits	167
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ARHGG_MOUSE
NC score	0.143215 (rank : 465)	θ value	0.365318 (rank : 368)
Query Neighborhood Hits	537	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SPN90_MOUSE
NC score	0.142595 (rank : 466)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

BLK_MOUSE
NC score	0.142324 (rank : 467)	θ value	0.000461057 (rank : 190)
Query Neighborhood Hits	537	Target Neighborhood Hits	992	Shared Neighborhood Hits	146
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SHAN2_MOUSE
NC score	0.142208 (rank : 468)	θ value	0.47712 (rank : 384)
Query Neighborhood Hits	537	Target Neighborhood Hits	446	Shared Neighborhood Hits	109
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

FRK_HUMAN
NC score	0.141595 (rank : 469)	θ value	0.00102713 (rank : 220)
Query Neighborhood Hits	537	Target Neighborhood Hits	1058	Shared Neighborhood Hits	188
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

DC1I1_MOUSE
NC score	0.141070 (rank : 470)	θ value	6.88961 (rank : 504)
Query Neighborhood Hits	537	Target Neighborhood Hits	206	Shared Neighborhood Hits	96
SwissProt Accessions	O88485, O88486	Gene names	Dync1i1, Dnci1, Dncic1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

M3K11_HUMAN
NC score	0.140029 (rank : 471)	θ value	4.92598e-06 (rank : 79)
Query Neighborhood Hits	537	Target Neighborhood Hits	1136	Shared Neighborhood Hits	193
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

WDR74_HUMAN
NC score	0.137958 (rank : 472)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	537	Target Neighborhood Hits	94	Shared Neighborhood Hits	70
SwissProt Accessions	Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2	Gene names	WDR74, NSA1
Domain Architecture	No domain graphic available
Description	WD repeat protein 74 (NOP seven-associated protein 1).

RASA1_HUMAN
NC score	0.137935 (rank : 473)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	537	Target Neighborhood Hits	258	Shared Neighborhood Hits	79
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

WDR54_MOUSE
NC score	0.137415 (rank : 474)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	537	Target Neighborhood Hits	96	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R0D8, Q3U4A4	Gene names	Wdr54, D3Mm3e
Domain Architecture	No domain graphic available
Description	WD repeat protein 54.

SHLB1_MOUSE
NC score	0.136250 (rank : 475)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	537	Target Neighborhood Hits	101	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SNX9_HUMAN
NC score	0.135389 (rank : 476)	θ value	2.36792 (rank : 456)
Query Neighborhood Hits	537	Target Neighborhood Hits	148	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

TCGAP_HUMAN
NC score	0.135372 (rank : 477)	θ value	0.47712 (rank : 386)
Query Neighborhood Hits	537	Target Neighborhood Hits	872	Shared Neighborhood Hits	137
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

M3K9_HUMAN
NC score	0.134603 (rank : 478)	θ value	0.000121331 (rank : 148)
Query Neighborhood Hits	537	Target Neighborhood Hits	1123	Shared Neighborhood Hits	188
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

TEC_HUMAN
NC score	0.133397 (rank : 479)	θ value	0.000121331 (rank : 152)
Query Neighborhood Hits	537	Target Neighborhood Hits	1006	Shared Neighborhood Hits	153
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

PI3R4_HUMAN
NC score	0.132899 (rank : 480)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	537	Target Neighborhood Hits	534	Shared Neighborhood Hits	129
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

LCK_HUMAN
NC score	0.132404 (rank : 481)	θ value	0.00509761 (rank : 262)
Query Neighborhood Hits	537	Target Neighborhood Hits	987	Shared Neighborhood Hits	130
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SHLB1_HUMAN
NC score	0.132308 (rank : 482)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	537	Target Neighborhood Hits	96	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

RIMB1_HUMAN
NC score	0.131871 (rank : 483)	θ value	0.125558 (rank : 343)
Query Neighborhood Hits	537	Target Neighborhood Hits	1479	Shared Neighborhood Hits	161
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TEC_MOUSE
NC score	0.131590 (rank : 484)	θ value	0.000121331 (rank : 153)
Query Neighborhood Hits	537	Target Neighborhood Hits	1006	Shared Neighborhood Hits	154
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LCK_MOUSE
NC score	0.131347 (rank : 485)	θ value	0.00509761 (rank : 263)
Query Neighborhood Hits	537	Target Neighborhood Hits	981	Shared Neighborhood Hits	130
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

PTK6_MOUSE
NC score	0.131023 (rank : 486)	θ value	0.00175202 (rank : 236)
Query Neighborhood Hits	537	Target Neighborhood Hits	1026	Shared Neighborhood Hits	168
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TXK_MOUSE
NC score	0.129248 (rank : 487)	θ value	0.279714 (rank : 366)
Query Neighborhood Hits	537	Target Neighborhood Hits	980	Shared Neighborhood Hits	151
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

WDR85_MOUSE
NC score	0.128531 (rank : 488)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	537	Target Neighborhood Hits	108	Shared Neighborhood Hits	76
SwissProt Accessions	Q9CYU6, Q5RJV7, Q8BIT9	Gene names	Wdr85
Domain Architecture	No domain graphic available
Description	WD repeat protein 85.

CIP4_HUMAN
NC score	0.128518 (rank : 489)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	537	Target Neighborhood Hits	374	Shared Neighborhood Hits	94
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

M3K10_HUMAN
NC score	0.128496 (rank : 490)	θ value	1.29631e-06 (rank : 67)
Query Neighborhood Hits	537	Target Neighborhood Hits	1071	Shared Neighborhood Hits	169
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

DOCK1_HUMAN
NC score	0.128370 (rank : 491)	θ value	0.125558 (rank : 339)
Query Neighborhood Hits	537	Target Neighborhood Hits	191	Shared Neighborhood Hits	116
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

PTK6_HUMAN
NC score	0.128294 (rank : 492)	θ value	0.00134147 (rank : 229)
Query Neighborhood Hits	537	Target Neighborhood Hits	1020	Shared Neighborhood Hits	167
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SH21B_MOUSE
NC score	0.127396 (rank : 493)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	537	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ARHGG_HUMAN
NC score	0.126610 (rank : 494)	θ value	2.36792 (rank : 447)
Query Neighborhood Hits	537	Target Neighborhood Hits	129	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

RIMB1_MOUSE
NC score	0.125960 (rank : 495)	θ value	0.813845 (rank : 404)
Query Neighborhood Hits	537	Target Neighborhood Hits	1376	Shared Neighborhood Hits	177
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ITK_HUMAN
NC score	0.124977 (rank : 496)	θ value	0.00869519 (rank : 272)
Query Neighborhood Hits	537	Target Neighborhood Hits	1016	Shared Neighborhood Hits	147
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

NBEA_HUMAN
NC score	0.124835 (rank : 497)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	537	Target Neighborhood Hits	186	Shared Neighborhood Hits	98
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
NC score	0.124794 (rank : 498)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	100
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

BRWD2_HUMAN
NC score	0.124629 (rank : 499)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	537	Target Neighborhood Hits	94	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BZH6, Q5VWA1	Gene names	BRWD2, WDR11
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 2 (WD repeat protein 11).

TXK_HUMAN
NC score	0.124481 (rank : 500)	θ value	0.0961366 (rank : 333)
Query Neighborhood Hits	537	Target Neighborhood Hits	971	Shared Neighborhood Hits	140
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

P85B_HUMAN
NC score	0.124380 (rank : 501)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	537	Target Neighborhood Hits	543	Shared Neighborhood Hits	100
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

AMPH_HUMAN
NC score	0.124375 (rank : 502)	θ value	0.47712 (rank : 382)
Query Neighborhood Hits	537	Target Neighborhood Hits	455	Shared Neighborhood Hits	93
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

WDR34_MOUSE
NC score	0.124225 (rank : 503)	θ value	5.27518 (rank : 499)
Query Neighborhood Hits	537	Target Neighborhood Hits	105	Shared Neighborhood Hits	79
SwissProt Accessions	Q5U4F6	Gene names	Wdr34
Domain Architecture	No domain graphic available
Description	WD repeat protein 34.

P85B_MOUSE
NC score	0.123974 (rank : 504)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	537	Target Neighborhood Hits	519	Shared Neighborhood Hits	101
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ABL1_HUMAN
NC score	0.122846 (rank : 505)	θ value	0.0736092 (rank : 312)
Query Neighborhood Hits	537	Target Neighborhood Hits	1220	Shared Neighborhood Hits	152
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

DAPP1_HUMAN
NC score	0.122582 (rank : 506)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

STS2_HUMAN
NC score	0.122518 (rank : 507)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	537	Target Neighborhood Hits	108	Shared Neighborhood Hits	81
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

DAPP1_MOUSE
NC score	0.122368 (rank : 508)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ABL1_MOUSE
NC score	0.122052 (rank : 509)	θ value	0.0736092 (rank : 313)
Query Neighborhood Hits	537	Target Neighborhood Hits	1178	Shared Neighborhood Hits	146
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SHLB2_MOUSE
NC score	0.122033 (rank : 510)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	537	Target Neighborhood Hits	88	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

LRBA_HUMAN
NC score	0.121672 (rank : 511)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	537	Target Neighborhood Hits	196	Shared Neighborhood Hits	91
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

CSK_HUMAN
NC score	0.120900 (rank : 512)	θ value	0.813845 (rank : 399)
Query Neighborhood Hits	537	Target Neighborhood Hits	1009	Shared Neighborhood Hits	150
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.120761 (rank : 513)	θ value	0.813845 (rank : 400)
Query Neighborhood Hits	537	Target Neighborhood Hits	1009	Shared Neighborhood Hits	150
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

PI3R4_MOUSE
NC score	0.120244 (rank : 514)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	537	Target Neighborhood Hits	535	Shared Neighborhood Hits	126
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

WDR8_HUMAN
NC score	0.120229 (rank : 515)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	537	Target Neighborhood Hits	69	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P2S5, Q5T0D6, Q9BUH7, Q9NTK7, Q9NX56	Gene names	WDR8
Domain Architecture
Description	WD repeat protein 8.

P55G_HUMAN
NC score	0.119318 (rank : 516)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	537	Target Neighborhood Hits	451	Shared Neighborhood Hits	78
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

ABL2_HUMAN
NC score	0.119239 (rank : 517)	θ value	0.125558 (rank : 336)
Query Neighborhood Hits	537	Target Neighborhood Hits	1045	Shared Neighborhood Hits	134
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

PPWD1_HUMAN
NC score	0.118563 (rank : 518)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	537	Target Neighborhood Hits	136	Shared Neighborhood Hits	95
SwissProt Accessions	Q96BP3, Q15002, Q7KZ89	Gene names	PPWD1, KIAA0073
Domain Architecture	No domain graphic available
Description	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).

WDR35_HUMAN
NC score	0.117978 (rank : 519)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	537	Target Neighborhood Hits	132	Shared Neighborhood Hits	96
SwissProt Accessions	Q9P2L0, Q8NE11	Gene names	WDR35, KIAA1336
Domain Architecture
Description	WD repeat protein 35.

ITK_MOUSE
NC score	0.117349 (rank : 520)	θ value	0.0961366 (rank : 330)
Query Neighborhood Hits	537	Target Neighborhood Hits	985	Shared Neighborhood Hits	134
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SH21B_HUMAN
NC score	0.116822 (rank : 521)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	537	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

P55G_MOUSE
NC score	0.116360 (rank : 522)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	537	Target Neighborhood Hits	401	Shared Neighborhood Hits	76
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SHLB2_HUMAN
NC score	0.115952 (rank : 523)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	537	Target Neighborhood Hits	86	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

MIA_HUMAN
NC score	0.115380 (rank : 524)	θ value	0.0563607 (rank : 306)
Query Neighborhood Hits	537	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

STS1_HUMAN
NC score	0.113612 (rank : 525)	θ value	1.38821 (rank : 430)
Query Neighborhood Hits	537	Target Neighborhood Hits	106	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

PPWD1_MOUSE
NC score	0.113565 (rank : 526)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	94
SwissProt Accessions	Q8CEC6	Gene names	Ppwd1
Domain Architecture	No domain graphic available
Description	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).

MIA_MOUSE
NC score	0.113533 (rank : 527)	θ value	0.0563607 (rank : 307)
Query Neighborhood Hits	537	Target Neighborhood Hits	17	Shared Neighborhood Hits	16
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

WDR8_MOUSE
NC score	0.111562 (rank : 528)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	537	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JM98	Gene names	Wdr8, Dd57
Domain Architecture
Description	WD repeat protein 8.

PKHG1_HUMAN
NC score	0.111185 (rank : 529)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	537	Target Neighborhood Hits	174	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

SNX9_MOUSE
NC score	0.110951 (rank : 530)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	537	Target Neighborhood Hits	141	Shared Neighborhood Hits	87
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

AMPH_MOUSE
NC score	0.110626 (rank : 531)	θ value	1.81305 (rank : 432)
Query Neighborhood Hits	537	Target Neighborhood Hits	291	Shared Neighborhood Hits	78
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

SRMS_MOUSE
NC score	0.109423 (rank : 532)	θ value	0.163984 (rank : 352)
Query Neighborhood Hits	537	Target Neighborhood Hits	964	Shared Neighborhood Hits	117
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STS1_MOUSE
NC score	0.106435 (rank : 533)	θ value	4.03905 (rank : 481)
Query Neighborhood Hits	537	Target Neighborhood Hits	104	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

WDR35_MOUSE
NC score	0.106187 (rank : 534)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	537	Target Neighborhood Hits	126	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BND3, Q8CDL4	Gene names	Wdr35
Domain Architecture
Description	WD repeat protein 35.

MCF2L_MOUSE
NC score	0.105217 (rank : 535)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	537	Target Neighborhood Hits	255	Shared Neighborhood Hits	54
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

SHE_MOUSE
NC score	0.104832 (rank : 536)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	537	Target Neighborhood Hits	169	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHAN1_HUMAN
NC score	0.104752 (rank : 537)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	537	Target Neighborhood Hits	1041	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

WDR34_HUMAN
NC score	0.104719 (rank : 538)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	537	Target Neighborhood Hits	100	Shared Neighborhood Hits	70
SwissProt Accessions	Q96EX3, Q5VXV4, Q9BV46	Gene names	WDR34
Domain Architecture
Description	WD repeat protein 34.

PREX1_HUMAN
NC score	0.104516 (rank : 539)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	537	Target Neighborhood Hits	177	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TIAM1_MOUSE
NC score	0.102866 (rank : 540)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	537	Target Neighborhood Hits	205	Shared Neighborhood Hits	31
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GRB14_MOUSE
NC score	0.101886 (rank : 541)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	537	Target Neighborhood Hits	149	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHE_HUMAN
NC score	0.101511 (rank : 542)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	537	Target Neighborhood Hits	164	Shared Neighborhood Hits	54
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SRMS_HUMAN
NC score	0.101332 (rank : 543)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	537	Target Neighborhood Hits	946	Shared Neighborhood Hits	96
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

BIN1_HUMAN
NC score	0.100920 (rank : 544)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	537	Target Neighborhood Hits	335	Shared Neighborhood Hits	89
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

TIAM1_HUMAN
NC score	0.099878 (rank : 545)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	32
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG8_MOUSE
NC score	0.099793 (rank : 546)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	537	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG3_MOUSE
NC score	0.099755 (rank : 547)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	537	Target Neighborhood Hits	85	Shared Neighborhood Hits	28
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.099694 (rank : 548)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	537	Target Neighborhood Hits	82	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

SHB_MOUSE
NC score	0.099660 (rank : 549)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	537	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

GRB14_HUMAN
NC score	0.099450 (rank : 550)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	537	Target Neighborhood Hits	137	Shared Neighborhood Hits	55
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SH21A_MOUSE
NC score	0.099422 (rank : 551)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	537	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SHB_HUMAN
NC score	0.097793 (rank : 552)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	537	Target Neighborhood Hits	141	Shared Neighborhood Hits	56
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

HSH2D_HUMAN
NC score	0.097547 (rank : 553)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	537	Target Neighborhood Hits	159	Shared Neighborhood Hits	48
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

WDR74_MOUSE
NC score	0.097273 (rank : 554)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	537	Target Neighborhood Hits	70	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCG3	Gene names	Wdr74
Domain Architecture	No domain graphic available
Description	WD repeat protein 74.

SH21A_HUMAN
NC score	0.095914 (rank : 555)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	537	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SHC1_MOUSE
NC score	0.095130 (rank : 556)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	537	Target Neighborhood Hits	180	Shared Neighborhood Hits	59
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

BIN1_MOUSE
NC score	0.094901 (rank : 557)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	537	Target Neighborhood Hits	283	Shared Neighborhood Hits	87
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

SHC3_MOUSE
NC score	0.094692 (rank : 558)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

APS_HUMAN
NC score	0.094437 (rank : 559)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	537	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SHC1_HUMAN
NC score	0.094320 (rank : 560)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	537	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHD_MOUSE
NC score	0.094213 (rank : 561)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	537	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC2_HUMAN
NC score	0.093285 (rank : 562)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	537	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHD_HUMAN
NC score	0.093131 (rank : 563)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	537	Target Neighborhood Hits	204	Shared Neighborhood Hits	56
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ARHG8_HUMAN
NC score	0.092769 (rank : 564)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	537	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

MATK_HUMAN
NC score	0.091823 (rank : 565)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	537	Target Neighborhood Hits	954	Shared Neighborhood Hits	92
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
NC score	0.091746 (rank : 566)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	537	Target Neighborhood Hits	952	Shared Neighborhood Hits	96
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

SHC2_MOUSE
NC score	0.090766 (rank : 567)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	537	Target Neighborhood Hits	144	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

RUSC2_HUMAN
NC score	0.089607 (rank : 568)	θ value	8.99809 (rank : 533)
Query Neighborhood Hits	537	Target Neighborhood Hits	205	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TF3C2_MOUSE
NC score	0.088707 (rank : 569)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	537	Target Neighborhood Hits	165	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

SHC3_HUMAN
NC score	0.088537 (rank : 570)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	537	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

MCF2_HUMAN
NC score	0.088124 (rank : 571)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	537	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

EM55_HUMAN
NC score	0.087538 (rank : 572)	θ value	1.81305 (rank : 436)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	90
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

BMX_MOUSE
NC score	0.087153 (rank : 573)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	537	Target Neighborhood Hits	912	Shared Neighborhood Hits	68
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BMX_HUMAN
NC score	0.086930 (rank : 574)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	537	Target Neighborhood Hits	942	Shared Neighborhood Hits	69
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

GRB7_MOUSE
NC score	0.086666 (rank : 575)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	537	Target Neighborhood Hits	157	Shared Neighborhood Hits	57
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

LNK_HUMAN
NC score	0.086220 (rank : 576)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ARHGA_MOUSE
NC score	0.085357 (rank : 577)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	537	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SLY_MOUSE
NC score	0.084035 (rank : 578)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	537	Target Neighborhood Hits	108	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

EM55_MOUSE
NC score	0.083464 (rank : 579)	θ value	5.27518 (rank : 486)
Query Neighborhood Hits	537	Target Neighborhood Hits	221	Shared Neighborhood Hits	87
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ARHGF_HUMAN
NC score	0.083255 (rank : 580)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	537	Target Neighborhood Hits	214	Shared Neighborhood Hits	31
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FER_HUMAN
NC score	0.082825 (rank : 581)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	537	Target Neighborhood Hits	1278	Shared Neighborhood Hits	105
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

LNK_MOUSE
NC score	0.082623 (rank : 582)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	537	Target Neighborhood Hits	132	Shared Neighborhood Hits	47
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MIA2_MOUSE
NC score	0.082107 (rank : 583)	θ value	0.0736092 (rank : 318)
Query Neighborhood Hits	537	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

ARHGA_HUMAN
NC score	0.081347 (rank : 584)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	537	Target Neighborhood Hits	187	Shared Neighborhood Hits	28
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_MOUSE
NC score	0.081075 (rank : 585)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	537	Target Neighborhood Hits	98	Shared Neighborhood Hits	28
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

BI2L1_HUMAN
NC score	0.081019 (rank : 586)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ZAP70_MOUSE
NC score	0.080557 (rank : 587)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	537	Target Neighborhood Hits	905	Shared Neighborhood Hits	73
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

STXB5_HUMAN
NC score	0.080440 (rank : 588)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	537	Target Neighborhood Hits	167	Shared Neighborhood Hits	105
SwissProt Accessions	Q5T5C0, Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9	Gene names	STXBP5, LLGL3
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5 (Tomosyn-1) (Lethal(2) giant larvae protein homolog 3).

WDR54_HUMAN
NC score	0.080084 (rank : 589)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	537	Target Neighborhood Hits	70	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H977, Q53H85, Q86V45	Gene names	WDR54
Domain Architecture	No domain graphic available
Description	WD repeat protein 54.

ZAP70_HUMAN
NC score	0.079929 (rank : 590)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	537	Target Neighborhood Hits	893	Shared Neighborhood Hits	73
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ECT2_HUMAN
NC score	0.078686 (rank : 591)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	537	Target Neighborhood Hits	98	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

GRB7_HUMAN
NC score	0.078659 (rank : 592)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	55
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

TF3C2_HUMAN
NC score	0.078606 (rank : 593)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	537	Target Neighborhood Hits	168	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

STB5L_HUMAN
NC score	0.078344 (rank : 594)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	537	Target Neighborhood Hits	139	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y2K9, Q4G1B4, Q6PIC3	Gene names	STXBP5L, KIAA1006, LLGL4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5-like (Tomosyn-2) (Lethal(2) giant larvae protein homolog 4).

KSYK_MOUSE
NC score	0.078039 (rank : 595)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	537	Target Neighborhood Hits	944	Shared Neighborhood Hits	75
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.077173 (rank : 596)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	537	Target Neighborhood Hits	901	Shared Neighborhood Hits	72
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LCP2_MOUSE
NC score	0.077002 (rank : 597)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	537	Target Neighborhood Hits	177	Shared Neighborhood Hits	45
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

ACK1_MOUSE
NC score	0.076806 (rank : 598)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	537	Target Neighborhood Hits	1080	Shared Neighborhood Hits	91
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

STB5L_MOUSE
NC score	0.076555 (rank : 599)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	537	Target Neighborhood Hits	138	Shared Neighborhood Hits	91
SwissProt Accessions	Q5DQR4, Q3TSM3, Q3UVG2, Q5DQR1, Q5DQR2, Q5DQR3, Q8BS52	Gene names	Stxbp5l, Llgl4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5-like (Tomosyn-2) (Lethal(2) giant larvae protein homolog 4).

SH24A_HUMAN
NC score	0.076381 (rank : 600)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	537	Target Neighborhood Hits	455	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

RHG12_MOUSE
NC score	0.076273 (rank : 601)	θ value	0.21417 (rank : 361)
Query Neighborhood Hits	537	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

HAPIP_HUMAN
NC score	0.075840 (rank : 602)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	537	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

MPP6_HUMAN
NC score	0.075694 (rank : 603)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	537	Target Neighborhood Hits	180	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

ACK1_HUMAN
NC score	0.075663 (rank : 604)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	537	Target Neighborhood Hits	1140	Shared Neighborhood Hits	86
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

RHG12_HUMAN
NC score	0.075417 (rank : 605)	θ value	0.0330416 (rank : 295)
Query Neighborhood Hits	537	Target Neighborhood Hits	190	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

MPP6_MOUSE
NC score	0.075385 (rank : 606)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	537	Target Neighborhood Hits	187	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

PTN11_MOUSE
NC score	0.075172 (rank : 607)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.075160 (rank : 608)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

GRB10_MOUSE
NC score	0.075055 (rank : 609)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	537	Target Neighborhood Hits	156	Shared Neighborhood Hits	54
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

RUSC2_MOUSE
NC score	0.075014 (rank : 610)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	537	Target Neighborhood Hits	305	Shared Neighborhood Hits	70
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ARHG1_HUMAN
NC score	0.074611 (rank : 611)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	537	Target Neighborhood Hits	176	Shared Neighborhood Hits	23
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

OTOR_HUMAN
NC score	0.074598 (rank : 612)	θ value	0.21417 (rank : 359)
Query Neighborhood Hits	537	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRC9	Gene names	OTOR, FDP, MIAL
Domain Architecture
Description	Otoraplin precursor (Fibrocyte-derived protein) (Melanoma inhibitory activity-like protein).

FGD4_MOUSE
NC score	0.073668 (rank : 613)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

GRB10_HUMAN
NC score	0.073649 (rank : 614)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	537	Target Neighborhood Hits	147	Shared Neighborhood Hits	54
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

SOCS7_MOUSE
NC score	0.073641 (rank : 615)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	537	Target Neighborhood Hits	154	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

ARHGB_HUMAN
NC score	0.073392 (rank : 616)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	537	Target Neighborhood Hits	375	Shared Neighborhood Hits	35
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FGD4_HUMAN
NC score	0.073152 (rank : 617)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	537	Target Neighborhood Hits	219	Shared Neighborhood Hits	36
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

STXB5_MOUSE
NC score	0.073147 (rank : 618)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	537	Target Neighborhood Hits	161	Shared Neighborhood Hits	100
SwissProt Accessions	Q8K400, Q80TM5, Q8K401, Q9D2F3	Gene names	Stxbp5, Kiaa4253, Llgl3
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5 (Tomosyn-1) (Lethal(2) giant larvae protein homolog 3).

WDR76_HUMAN
NC score	0.072805 (rank : 619)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	537	Target Neighborhood Hits	73	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H967	Gene names	WDR76
Domain Architecture	No domain graphic available
Description	WD repeat protein 76.

TULP4_MOUSE
NC score	0.072688 (rank : 620)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	537	Target Neighborhood Hits	247	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JIL5, Q8CA75, Q922C2	Gene names	Tulp4, Tusp
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

TEX14_MOUSE
NC score	0.072493 (rank : 621)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	537	Target Neighborhood Hits	1333	Shared Neighborhood Hits	86
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

FGD3_MOUSE
NC score	0.072139 (rank : 622)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	537	Target Neighborhood Hits	257	Shared Neighborhood Hits	37
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHGC_MOUSE
NC score	0.072026 (rank : 623)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	537	Target Neighborhood Hits	344	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.072026 (rank : 624)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	537	Target Neighborhood Hits	351	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ILK_MOUSE
NC score	0.071627 (rank : 625)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	537	Target Neighborhood Hits	858	Shared Neighborhood Hits	60
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

TEX14_HUMAN
NC score	0.071453 (rank : 626)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	537	Target Neighborhood Hits	1103	Shared Neighborhood Hits	76
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ILK1_HUMAN
NC score	0.071441 (rank : 627)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	537	Target Neighborhood Hits	857	Shared Neighborhood Hits	60
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

TR95_MOUSE
NC score	0.071305 (rank : 628)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	537	Target Neighborhood Hits	95	Shared Neighborhood Hits	72
SwissProt Accessions	Q6PGF3	Gene names	Thrap5
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein complex 95 kDa component (Trap95) (Thyroid hormone receptor-associated protein 5) (Vitamin D3 receptor-interacting protein complex component DRIP92).

ILK2_HUMAN
NC score	0.070884 (rank : 629)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	537	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

RYK_HUMAN
NC score	0.070693 (rank : 630)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	537	Target Neighborhood Hits	701	Shared Neighborhood Hits	42
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

SLY_HUMAN
NC score	0.070562 (rank : 631)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	537	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

LTK_HUMAN
NC score	0.070436 (rank : 632)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	537	Target Neighborhood Hits	774	Shared Neighborhood Hits	49
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

APS_MOUSE
NC score	0.070298 (rank : 633)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	537	Target Neighborhood Hits	134	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

LCP2_HUMAN
NC score	0.070277 (rank : 634)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	537	Target Neighborhood Hits	531	Shared Neighborhood Hits	60
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LTK_MOUSE
NC score	0.070076 (rank : 635)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	537	Target Neighborhood Hits	770	Shared Neighborhood Hits	48
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

FES_HUMAN
NC score	0.070063 (rank : 636)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	537	Target Neighborhood Hits	978	Shared Neighborhood Hits	67
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

RYK_MOUSE
NC score	0.069867 (rank : 637)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	537	Target Neighborhood Hits	715	Shared Neighborhood Hits	42
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

WIPI1_MOUSE
NC score	0.069525 (rank : 638)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	537	Target Neighborhood Hits	67	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R3E3, Q8BGE1, Q8R1A9, Q8R1C7	Gene names	Wipi1, D11Ertd498e
Domain Architecture	No domain graphic available
Description	WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa).

ALK_MOUSE
NC score	0.069458 (rank : 639)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	537	Target Neighborhood Hits	811	Shared Neighborhood Hits	50
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

STYK1_MOUSE
NC score	0.069406 (rank : 640)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	537	Target Neighborhood Hits	779	Shared Neighborhood Hits	47
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

FGD2_HUMAN
NC score	0.069173 (rank : 641)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

STYK1_HUMAN
NC score	0.069173 (rank : 642)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	537	Target Neighborhood Hits	786	Shared Neighborhood Hits	45
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

ALK_HUMAN
NC score	0.068947 (rank : 643)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	537	Target Neighborhood Hits	795	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ROS_HUMAN
NC score	0.068568 (rank : 644)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	537	Target Neighborhood Hits	907	Shared Neighborhood Hits	47
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

TNK1_HUMAN
NC score	0.067959 (rank : 645)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	537	Target Neighborhood Hits	815	Shared Neighborhood Hits	51
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

FES_MOUSE
NC score	0.067729 (rank : 646)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	537	Target Neighborhood Hits	980	Shared Neighborhood Hits	59
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TNK1_MOUSE
NC score	0.067553 (rank : 647)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	537	Target Neighborhood Hits	806	Shared Neighborhood Hits	51
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TULP4_HUMAN
NC score	0.067537 (rank : 648)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	537	Target Neighborhood Hits	426	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

SH22A_MOUSE
NC score	0.067429 (rank : 649)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	537	Target Neighborhood Hits	179	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

DDR1_MOUSE
NC score	0.067245 (rank : 650)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	537	Target Neighborhood Hits	818	Shared Neighborhood Hits	46
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.066592 (rank : 651)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	537	Target Neighborhood Hits	819	Shared Neighborhood Hits	48
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

BI2L1_MOUSE
NC score	0.066567 (rank : 652)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	537	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

FGD3_HUMAN
NC score	0.066440 (rank : 653)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	537	Target Neighborhood Hits	249	Shared Neighborhood Hits	32
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

CHIN_MOUSE
NC score	0.066381 (rank : 654)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	537	Target Neighborhood Hits	229	Shared Neighborhood Hits	59
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

PPIP2_HUMAN
NC score	0.066376 (rank : 655)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	537	Target Neighborhood Hits	254	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

EPHAA_HUMAN
NC score	0.066358 (rank : 656)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	537	Target Neighborhood Hits	960	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

FGD2_MOUSE
NC score	0.066302 (rank : 657)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	537	Target Neighborhood Hits	163	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

RGNEF_MOUSE
NC score	0.066200 (rank : 658)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	537	Target Neighborhood Hits	641	Shared Neighborhood Hits	59
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

IF140_HUMAN
NC score	0.066171 (rank : 659)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	537	Target Neighborhood Hits	111	Shared Neighborhood Hits	57
SwissProt Accessions	Q96RY7, O60332	Gene names	IFT140, KIAA0590, WDTC2
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 140 homolog (WD and tetratricopeptide repeats protein 2).

MPP5_HUMAN
NC score	0.066140 (rank : 660)	θ value	0.62314 (rank : 393)
Query Neighborhood Hits	537	Target Neighborhood Hits	231	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

EPHB6_HUMAN
NC score	0.065940 (rank : 661)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	537	Target Neighborhood Hits	912	Shared Neighborhood Hits	47
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

OTOR_MOUSE
NC score	0.065917 (rank : 662)	θ value	1.81305 (rank : 437)
Query Neighborhood Hits	537	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JIE3	Gene names	Otor, Mial
Domain Architecture
Description	Otoraplin precursor (Melanoma inhibitory activity-like protein).

AATK_MOUSE
NC score	0.065652 (rank : 663)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	537	Target Neighborhood Hits	942	Shared Neighborhood Hits	54
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

FAK2_HUMAN
NC score	0.065604 (rank : 664)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	537	Target Neighborhood Hits	847	Shared Neighborhood Hits	48
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

MPP5_MOUSE
NC score	0.065526 (rank : 665)	θ value	0.62314 (rank : 394)
Query Neighborhood Hits	537	Target Neighborhood Hits	226	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

FAK2_MOUSE
NC score	0.065382 (rank : 666)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	537	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

BCR_HUMAN
NC score	0.065334 (rank : 667)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	537	Target Neighborhood Hits	204	Shared Neighborhood Hits	37
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

FLT3_MOUSE
NC score	0.065256 (rank : 668)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	537	Target Neighborhood Hits	847	Shared Neighborhood Hits	47
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

EPHB6_MOUSE
NC score	0.065054 (rank : 669)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	537	Target Neighborhood Hits	906	Shared Neighborhood Hits	47
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

CHIN_HUMAN
NC score	0.065030 (rank : 670)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	537	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

FLT3_HUMAN
NC score	0.064880 (rank : 671)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	537	Target Neighborhood Hits	843	Shared Neighborhood Hits	47
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

ERBB3_HUMAN
NC score	0.064401 (rank : 672)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	537	Target Neighborhood Hits	918	Shared Neighborhood Hits	45
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

IGF1R_MOUSE
NC score	0.064386 (rank : 673)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	537	Target Neighborhood Hits	973	Shared Neighborhood Hits	48
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_HUMAN
NC score	0.064340 (rank : 674)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	537	Target Neighborhood Hits	950	Shared Neighborhood Hits	52
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

GNRP_MOUSE
NC score	0.064337 (rank : 675)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	537	Target Neighborhood Hits	191	Shared Neighborhood Hits	27
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ERBB2_MOUSE
NC score	0.064280 (rank : 676)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	537	Target Neighborhood Hits	918	Shared Neighborhood Hits	47
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB4_HUMAN
NC score	0.064212 (rank : 677)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	537	Target Neighborhood Hits	910	Shared Neighborhood Hits	51
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

IGF1R_HUMAN
NC score	0.064192 (rank : 678)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	537	Target Neighborhood Hits	977	Shared Neighborhood Hits	49
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

SH2D3_MOUSE
NC score	0.064181 (rank : 679)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	537	Target Neighborhood Hits	174	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

CSF1R_HUMAN
NC score	0.064178 (rank : 680)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	537	Target Neighborhood Hits	943	Shared Neighborhood Hits	48
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ERBB2_HUMAN
NC score	0.064099 (rank : 681)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	537	Target Neighborhood Hits	1073	Shared Neighborhood Hits	54
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB3_MOUSE
NC score	0.064090 (rank : 682)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	537	Target Neighborhood Hits	898	Shared Neighborhood Hits	46
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

KIT_MOUSE
NC score	0.064049 (rank : 683)	θ value	3.0926 (rank : 461)
Query Neighborhood Hits	537	Target Neighborhood Hits	949	Shared Neighborhood Hits	48
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

INSRR_MOUSE
NC score	0.064014 (rank : 684)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	537	Target Neighborhood Hits	961	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

CHIO_HUMAN
NC score	0.063823 (rank : 685)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	537	Target Neighborhood Hits	220	Shared Neighborhood Hits	54
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

AATK_HUMAN
NC score	0.063814 (rank : 686)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	537	Target Neighborhood Hits	1243	Shared Neighborhood Hits	56
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

RON_MOUSE
NC score	0.063768 (rank : 687)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	537	Target Neighborhood Hits	836	Shared Neighborhood Hits	45
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR2_MOUSE
NC score	0.063507 (rank : 688)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	537	Target Neighborhood Hits	1000	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

NTRK1_HUMAN
NC score	0.063480 (rank : 689)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	537	Target Neighborhood Hits	1023	Shared Neighborhood Hits	47
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

EPHA6_HUMAN
NC score	0.063440 (rank : 690)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	537	Target Neighborhood Hits	959	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA1_MOUSE
NC score	0.063401 (rank : 691)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	537	Target Neighborhood Hits	958	Shared Neighborhood Hits	50
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

PTN6_MOUSE
NC score	0.063287 (rank : 692)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	537	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

EPHA6_MOUSE
NC score	0.063281 (rank : 693)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	537	Target Neighborhood Hits	946	Shared Neighborhood Hits	49
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

DDR2_HUMAN
NC score	0.063206 (rank : 694)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	537	Target Neighborhood Hits	818	Shared Neighborhood Hits	49
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA1_HUMAN
NC score	0.063076 (rank : 695)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	537	Target Neighborhood Hits	997	Shared Neighborhood Hits	51
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA5_MOUSE
NC score	0.063056 (rank : 696)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	537	Target Neighborhood Hits	950	Shared Neighborhood Hits	51
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

ARHG1_MOUSE
NC score	0.062949 (rank : 697)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	537	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

RHG09_HUMAN
NC score	0.062825 (rank : 698)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	537	Target Neighborhood Hits	186	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

PGFRA_MOUSE
NC score	0.062793 (rank : 699)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	537	Target Neighborhood Hits	975	Shared Neighborhood Hits	48
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

RON_HUMAN
NC score	0.062771 (rank : 700)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	537	Target Neighborhood Hits	842	Shared Neighborhood Hits	45
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

DDR2_MOUSE
NC score	0.062700 (rank : 701)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	537	Target Neighborhood Hits	813	Shared Neighborhood Hits	45
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FGD1_HUMAN
NC score	0.062598 (rank : 702)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	537	Target Neighborhood Hits	367	Shared Neighborhood Hits	43
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FAK1_MOUSE
NC score	0.062587 (rank : 703)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	537	Target Neighborhood Hits	850	Shared Neighborhood Hits	49
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK1_HUMAN
NC score	0.062509 (rank : 704)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	537	Target Neighborhood Hits	850	Shared Neighborhood Hits	47
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

WDR19_HUMAN
NC score	0.062494 (rank : 705)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	537	Target Neighborhood Hits	88	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NEZ3, Q8N5B4, Q9H5S0, Q9HCD4	Gene names	WDR19, KIAA1638
Domain Architecture	No domain graphic available
Description	WD repeat protein 19.

PGFRA_HUMAN
NC score	0.062460 (rank : 706)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	537	Target Neighborhood Hits	980	Shared Neighborhood Hits	48
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

INSR_HUMAN
NC score	0.062453 (rank : 707)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	537	Target Neighborhood Hits	963	Shared Neighborhood Hits	49
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

PGFRB_MOUSE
NC score	0.062387 (rank : 708)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	537	Target Neighborhood Hits	960	Shared Neighborhood Hits	49
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

INSR_MOUSE
NC score	0.062385 (rank : 709)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	537	Target Neighborhood Hits	968	Shared Neighborhood Hits	48
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

MLKL_HUMAN
NC score	0.062373 (rank : 710)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	537	Target Neighborhood Hits	600	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

PGFRB_HUMAN
NC score	0.062212 (rank : 711)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	537	Target Neighborhood Hits	962	Shared Neighborhood Hits	47
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

ARHG2_HUMAN
NC score	0.062155 (rank : 712)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	537	Target Neighborhood Hits	142	Shared Neighborhood Hits	31
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

TRIO_HUMAN
NC score	0.061987 (rank : 713)	θ value	0.365318 (rank : 378)
Query Neighborhood Hits	537	Target Neighborhood Hits	1580	Shared Neighborhood Hits	121
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PTN6_HUMAN
NC score	0.061971 (rank : 714)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	537	Target Neighborhood Hits	234	Shared Neighborhood Hits	60
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

ARHG2_MOUSE
NC score	0.061963 (rank : 715)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	537	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

WIPI1_HUMAN
NC score	0.061868 (rank : 716)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	537	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q5MNZ9, Q8IXM5, Q9NWF8	Gene names	WIPI1, WIPI49
Domain Architecture	No domain graphic available
Description	WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa) (Atg18 protein homolog).

RET_HUMAN
NC score	0.061862 (rank : 717)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	537	Target Neighborhood Hits	873	Shared Neighborhood Hits	48
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

MERTK_HUMAN
NC score	0.061826 (rank : 718)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	537	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

KIT_HUMAN
NC score	0.061800 (rank : 719)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	537	Target Neighborhood Hits	953	Shared Neighborhood Hits	47
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

ROR2_HUMAN
NC score	0.061783 (rank : 720)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	537	Target Neighborhood Hits	1014	Shared Neighborhood Hits	48
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

EPHA2_MOUSE
NC score	0.061755 (rank : 721)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	537	Target Neighborhood Hits	1020	Shared Neighborhood Hits	52
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EGFR_HUMAN
NC score	0.061726 (rank : 722)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	537	Target Neighborhood Hits	939	Shared Neighborhood Hits	46
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
NC score	0.061722 (rank : 723)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	537	Target Neighborhood Hits	927	Shared Neighborhood Hits	46
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

PPIP2_MOUSE
NC score	0.061700 (rank : 724)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	537	Target Neighborhood Hits	308	Shared Neighborhood Hits	29
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

EPHA2_HUMAN
NC score	0.061522 (rank : 725)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	537	Target Neighborhood Hits	1021	Shared Neighborhood Hits	52
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

WIPI3_MOUSE
NC score	0.061493 (rank : 726)	θ value	8.99809 (rank : 537)
Query Neighborhood Hits	537	Target Neighborhood Hits	51	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CR39, Q3U924	Gene names	Wdr45l, Wipi3
Domain Architecture	No domain graphic available
Description	WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat protein 45-like) (WDR45-like protein).

RET_MOUSE
NC score	0.061450 (rank : 727)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	537	Target Neighborhood Hits	884	Shared Neighborhood Hits	47
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

MERTK_MOUSE
NC score	0.061372 (rank : 728)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	537	Target Neighborhood Hits	974	Shared Neighborhood Hits	43
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

CSF1R_MOUSE
NC score	0.061365 (rank : 729)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	537	Target Neighborhood Hits	983	Shared Neighborhood Hits	48
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHB3_MOUSE
NC score	0.061345 (rank : 730)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	537	Target Neighborhood Hits	996	Shared Neighborhood Hits	54
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

FGD1_MOUSE
NC score	0.061220 (rank : 731)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	537	Target Neighborhood Hits	387	Shared Neighborhood Hits	44
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SH2D3_HUMAN
NC score	0.061199 (rank : 732)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	537	Target Neighborhood Hits	188	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

EPHB3_HUMAN
NC score	0.061196 (rank : 733)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	537	Target Neighborhood Hits	996	Shared Neighborhood Hits	54
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

MET_MOUSE
NC score	0.061022 (rank : 734)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	537	Target Neighborhood Hits	844	Shared Neighborhood Hits	45
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

WIPI3_HUMAN
NC score	0.061004 (rank : 735)	θ value	8.99809 (rank : 536)
Query Neighborhood Hits	537	Target Neighborhood Hits	53	Shared Neighborhood Hits	33
SwissProt Accessions	Q5MNZ6, O95328, Q6IBN2	Gene names	WDR45L, WIPI3
Domain Architecture	No domain graphic available
Description	WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat protein 45-like) (WDR45-like protein) (WIPI49-like protein).

EPHB4_HUMAN
NC score	0.060972 (rank : 736)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	537	Target Neighborhood Hits	1056	Shared Neighborhood Hits	51
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB2_HUMAN
NC score	0.060939 (rank : 737)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	537	Target Neighborhood Hits	983	Shared Neighborhood Hits	52
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

MET_HUMAN
NC score	0.060846 (rank : 738)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	537	Target Neighborhood Hits	831	Shared Neighborhood Hits	46
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHB4_MOUSE
NC score	0.060840 (rank : 739)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	537	Target Neighborhood Hits	1013	Shared Neighborhood Hits	51
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB2_MOUSE
NC score	0.060778 (rank : 740)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	537	Target Neighborhood Hits	982	Shared Neighborhood Hits	52
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

SH22A_HUMAN
NC score	0.060713 (rank : 741)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	537	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

NTRK3_HUMAN
NC score	0.060621 (rank : 742)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	537	Target Neighborhood Hits	1115	Shared Neighborhood Hits	45
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

EPHA8_MOUSE
NC score	0.060597 (rank : 743)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	537	Target Neighborhood Hits	969	Shared Neighborhood Hits	49
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

LBC_HUMAN
NC score	0.060529 (rank : 744)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	537	Target Neighborhood Hits	90	Shared Neighborhood Hits	25
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ROR1_MOUSE
NC score	0.060444 (rank : 745)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	537	Target Neighborhood Hits	1025	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

UFO_HUMAN
NC score	0.060413 (rank : 746)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	537	Target Neighborhood Hits	981	Shared Neighborhood Hits	50
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

HSH2D_MOUSE
NC score	0.060389 (rank : 747)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	537	Target Neighborhood Hits	124	Shared Neighborhood Hits	35
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

EPHA8_HUMAN
NC score	0.060380 (rank : 748)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	537	Target Neighborhood Hits	956	Shared Neighborhood Hits	48
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

ROR1_HUMAN
NC score	0.060315 (rank : 749)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	537	Target Neighborhood Hits	1018	Shared Neighborhood Hits	49
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

WDR19_MOUSE
NC score	0.060108 (rank : 750)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	537	Target Neighborhood Hits	83	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UGF1, Q6ZPK8, Q80VQ6, Q8C794, Q8K3R5	Gene names	Wdr19, Kiaa1638
Domain Architecture	No domain graphic available
Description	WD repeat protein 19.

UFO_MOUSE
NC score	0.060051 (rank : 751)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	537	Target Neighborhood Hits	988	Shared Neighborhood Hits	50
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

EPHA5_HUMAN
NC score	0.060017 (rank : 752)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	537	Target Neighborhood Hits	1009	Shared Neighborhood Hits	51
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA4_HUMAN
NC score	0.059979 (rank : 753)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	537	Target Neighborhood Hits	975	Shared Neighborhood Hits	50
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
NC score	0.059967 (rank : 754)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	537	Target Neighborhood Hits	982	Shared Neighborhood Hits	51
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

BAIP2_MOUSE
NC score	0.059937 (rank : 755)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	537	Target Neighborhood Hits	185	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

MLKL_MOUSE
NC score	0.059831 (rank : 756)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	537	Target Neighborhood Hits	707	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

EPHB1_HUMAN
NC score	0.059582 (rank : 757)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	537	Target Neighborhood Hits	988	Shared Neighborhood Hits	52
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

FGFR4_MOUSE
NC score	0.059372 (rank : 758)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	537	Target Neighborhood Hits	1026	Shared Neighborhood Hits	46
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

TYRO3_MOUSE
NC score	0.059313 (rank : 759)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	537	Target Neighborhood Hits	1007	Shared Neighborhood Hits	45
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

BLNK_MOUSE
NC score	0.059254 (rank : 760)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	537	Target Neighborhood Hits	296	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

TYRO3_HUMAN
NC score	0.059047 (rank : 761)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	537	Target Neighborhood Hits	995	Shared Neighborhood Hits	44
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

BAIP2_HUMAN
NC score	0.058943 (rank : 762)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	537	Target Neighborhood Hits	192	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

IRAK3_MOUSE
NC score	0.058880 (rank : 763)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	537	Target Neighborhood Hits	628	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

EPHA7_MOUSE
NC score	0.058845 (rank : 764)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	537	Target Neighborhood Hits	1025	Shared Neighborhood Hits	52
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA7_HUMAN
NC score	0.058709 (rank : 765)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	537	Target Neighborhood Hits	1053	Shared Neighborhood Hits	52
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA3_MOUSE
NC score	0.058557 (rank : 766)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	537	Target Neighborhood Hits	1009	Shared Neighborhood Hits	51
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA3_HUMAN
NC score	0.058510 (rank : 767)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	537	Target Neighborhood Hits	1005	Shared Neighborhood Hits	50
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

NTRK2_HUMAN
NC score	0.058496 (rank : 768)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	537	Target Neighborhood Hits	1081	Shared Neighborhood Hits	47
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.058494 (rank : 769)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	537	Target Neighborhood Hits	1088	Shared Neighborhood Hits	47
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

ABR_HUMAN
NC score	0.058327 (rank : 770)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	537	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ANPRA_MOUSE
NC score	0.058299 (rank : 771)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	537	Target Neighborhood Hits	600	Shared Neighborhood Hits	39
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

SOCS6_HUMAN
NC score	0.058133 (rank : 772)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	537	Target Neighborhood Hits	126	Shared Neighborhood Hits	42
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

ANPRA_HUMAN
NC score	0.058057 (rank : 773)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	537	Target Neighborhood Hits	612	Shared Neighborhood Hits	39
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

FGFR4_HUMAN
NC score	0.057953 (rank : 774)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	537	Target Neighborhood Hits	1037	Shared Neighborhood Hits	47
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

SOCS6_MOUSE
NC score	0.057870 (rank : 775)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	537	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

GUC2F_HUMAN
NC score	0.057737 (rank : 776)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	537	Target Neighborhood Hits	740	Shared Neighborhood Hits	43
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

FGD6_MOUSE
NC score	0.057410 (rank : 777)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	35
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

MUSK_MOUSE
NC score	0.056929 (rank : 778)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	537	Target Neighborhood Hits	1057	Shared Neighborhood Hits	47
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MUSK_HUMAN
NC score	0.056651 (rank : 779)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	537	Target Neighborhood Hits	1074	Shared Neighborhood Hits	47
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

JAK1_HUMAN
NC score	0.056425 (rank : 780)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	537	Target Neighborhood Hits	858	Shared Neighborhood Hits	51
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

RAF1_HUMAN
NC score	0.056198 (rank : 781)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	537	Target Neighborhood Hits	886	Shared Neighborhood Hits	56
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ARAF_MOUSE
NC score	0.056158 (rank : 782)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	537	Target Neighborhood Hits	874	Shared Neighborhood Hits	55
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

FGFR3_HUMAN
NC score	0.056100 (rank : 783)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	537	Target Neighborhood Hits	1042	Shared Neighborhood Hits	47
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

VGFR3_HUMAN
NC score	0.055928 (rank : 784)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	537	Target Neighborhood Hits	1037	Shared Neighborhood Hits	47
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

MLTK_MOUSE
NC score	0.055906 (rank : 785)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	537	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.055880 (rank : 786)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	537	Target Neighborhood Hits	911	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

ARAF_HUMAN
NC score	0.055878 (rank : 787)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	537	Target Neighborhood Hits	924	Shared Neighborhood Hits	57
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

RAF1_MOUSE
NC score	0.055757 (rank : 788)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	537	Target Neighborhood Hits	886	Shared Neighborhood Hits	56
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

IRAK3_HUMAN
NC score	0.055739 (rank : 789)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	537	Target Neighborhood Hits	644	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

FGFR3_MOUSE
NC score	0.055694 (rank : 790)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	537	Target Neighborhood Hits	1059	Shared Neighborhood Hits	47
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR2_MOUSE
NC score	0.055636 (rank : 791)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	537	Target Neighborhood Hits	1062	Shared Neighborhood Hits	47
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

VGFR3_MOUSE
NC score	0.055628 (rank : 792)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	537	Target Neighborhood Hits	1056	Shared Neighborhood Hits	48
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

TIE1_HUMAN
NC score	0.055528 (rank : 793)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	537	Target Neighborhood Hits	1241	Shared Neighborhood Hits	48
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

JAK1_MOUSE
NC score	0.055523 (rank : 794)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	537	Target Neighborhood Hits	854	Shared Neighborhood Hits	48
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

GNRP_HUMAN
NC score	0.055518 (rank : 795)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	537	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

TIE2_HUMAN
NC score	0.055512 (rank : 796)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	537	Target Neighborhood Hits	1192	Shared Neighborhood Hits	48
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

FARP2_MOUSE
NC score	0.055506 (rank : 797)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	537	Target Neighborhood Hits	209	Shared Neighborhood Hits	30
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

DOCK2_MOUSE
NC score	0.055488 (rank : 798)	θ value	0.21417 (rank : 357)
Query Neighborhood Hits	537	Target Neighborhood Hits	104	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

TIE2_MOUSE
NC score	0.055372 (rank : 799)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	537	Target Neighborhood Hits	1204	Shared Neighborhood Hits	48
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

BRAF1_HUMAN
NC score	0.055281 (rank : 800)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	537	Target Neighborhood Hits	883	Shared Neighborhood Hits	57
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

TIE1_MOUSE
NC score	0.055279 (rank : 801)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	537	Target Neighborhood Hits	1266	Shared Neighborhood Hits	48
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

FGFR2_HUMAN
NC score	0.055277 (rank : 802)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	537	Target Neighborhood Hits	1062	Shared Neighborhood Hits	47
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

MOS_HUMAN
NC score	0.055033 (rank : 803)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	537	Target Neighborhood Hits	829	Shared Neighborhood Hits	47
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

FGFR1_MOUSE
NC score	0.055000 (rank : 804)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	537	Target Neighborhood Hits	1068	Shared Neighborhood Hits	47
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.054996 (rank : 805)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	537	Target Neighborhood Hits	1069	Shared Neighborhood Hits	47
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

MPP2_HUMAN
NC score	0.054968 (rank : 806)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	537	Target Neighborhood Hits	173	Shared Neighborhood Hits	67
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MOS_MOUSE
NC score	0.054962 (rank : 807)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	537	Target Neighborhood Hits	833	Shared Neighborhood Hits	49
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

GUC2G_MOUSE
NC score	0.054933 (rank : 808)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	537	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ANPRB_MOUSE
NC score	0.054707 (rank : 809)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	537	Target Neighborhood Hits	607	Shared Neighborhood Hits	42
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2C_HUMAN
NC score	0.054672 (rank : 810)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	537	Target Neighborhood Hits	624	Shared Neighborhood Hits	39
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

TYK2_MOUSE
NC score	0.054668 (rank : 811)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	537	Target Neighborhood Hits	850	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

PTK7_HUMAN
NC score	0.054453 (rank : 812)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	537	Target Neighborhood Hits	1103	Shared Neighborhood Hits	50
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

MPP2_MOUSE
NC score	0.054346 (rank : 813)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	537	Target Neighborhood Hits	189	Shared Neighborhood Hits	66
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

BCAR3_HUMAN
NC score	0.054255 (rank : 814)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	537	Target Neighborhood Hits	129	Shared Neighborhood Hits	41
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BLNK_HUMAN
NC score	0.054194 (rank : 815)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

TYK2_HUMAN
NC score	0.054158 (rank : 816)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	537	Target Neighborhood Hits	841	Shared Neighborhood Hits	47
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

K0329_HUMAN
NC score	0.054026 (rank : 817)	θ value	0.125558 (rank : 341)
Query Neighborhood Hits	537	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	O15040, Q9UEG6	Gene names	KIAA0329, KIAA0297
Domain Architecture
Description	Protein KIAA0329/KIAA0297.

FGD6_HUMAN
NC score	0.053928 (rank : 818)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	537	Target Neighborhood Hits	237	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

JAK3_HUMAN
NC score	0.053859 (rank : 819)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	537	Target Neighborhood Hits	827	Shared Neighborhood Hits	47
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

ANPRB_HUMAN
NC score	0.053841 (rank : 820)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	537	Target Neighborhood Hits	646	Shared Neighborhood Hits	42
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

VGFR2_MOUSE
NC score	0.053458 (rank : 821)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	537	Target Neighborhood Hits	1089	Shared Neighborhood Hits	47
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR2_HUMAN
NC score	0.053242 (rank : 822)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	537	Target Neighborhood Hits	1103	Shared Neighborhood Hits	49
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

SH24A_MOUSE
NC score	0.053038 (rank : 823)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	537	Target Neighborhood Hits	326	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

IRAK2_HUMAN
NC score	0.053034 (rank : 824)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	537	Target Neighborhood Hits	714	Shared Neighborhood Hits	49
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

BCAR3_MOUSE
NC score	0.053000 (rank : 825)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	537	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

KSR1_HUMAN
NC score	0.052677 (rank : 826)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	537	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR2_HUMAN
NC score	0.052642 (rank : 827)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	537	Target Neighborhood Hits	920	Shared Neighborhood Hits	53
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

M3K13_HUMAN
NC score	0.052368 (rank : 828)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	537	Target Neighborhood Hits	911	Shared Neighborhood Hits	52
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

IRAK1_MOUSE
NC score	0.052338 (rank : 829)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	537	Target Neighborhood Hits	784	Shared Neighborhood Hits	46
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

VGFR1_HUMAN
NC score	0.052271 (rank : 830)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	537	Target Neighborhood Hits	1109	Shared Neighborhood Hits	48
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

M3K12_HUMAN
NC score	0.052151 (rank : 831)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	537	Target Neighborhood Hits	940	Shared Neighborhood Hits	54
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.052026 (rank : 832)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	537	Target Neighborhood Hits	957	Shared Neighborhood Hits	52
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

VGFR1_MOUSE
NC score	0.051715 (rank : 833)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	537	Target Neighborhood Hits	1118	Shared Neighborhood Hits	47
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

MPP4_MOUSE
NC score	0.051678 (rank : 834)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	537	Target Neighborhood Hits	188	Shared Neighborhood Hits	58
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

KSR1_MOUSE
NC score	0.051504 (rank : 835)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	537	Target Neighborhood Hits	870	Shared Neighborhood Hits	53
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

JAK2_HUMAN
NC score	0.051463 (rank : 836)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	537	Target Neighborhood Hits	847	Shared Neighborhood Hits	48
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
NC score	0.051460 (rank : 837)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	537	Target Neighborhood Hits	839	Shared Neighborhood Hits	47
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

FARP1_HUMAN
NC score	0.051376 (rank : 838)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	537	Target Neighborhood Hits	241	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
NC score	0.051297 (rank : 839)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	537	Target Neighborhood Hits	240	Shared Neighborhood Hits	28
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

BMR1B_MOUSE
NC score	0.051173 (rank : 840)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	537	Target Neighborhood Hits	758	Shared Neighborhood Hits	42
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

TNI3K_MOUSE
NC score	0.051164 (rank : 841)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	537	Target Neighborhood Hits	1079	Shared Neighborhood Hits	60
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

GUC2D_HUMAN
NC score	0.051101 (rank : 842)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	537	Target Neighborhood Hits	715	Shared Neighborhood Hits	42
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

RIPK1_MOUSE
NC score	0.051045 (rank : 843)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	537	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

JAK3_MOUSE
NC score	0.051019 (rank : 844)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	537	Target Neighborhood Hits	821	Shared Neighborhood Hits	47
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

GUC2E_MOUSE
NC score	0.051002 (rank : 845)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	537	Target Neighborhood Hits	692	Shared Neighborhood Hits	42
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

SASH1_HUMAN
NC score	0.050949 (rank : 846)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	537	Target Neighborhood Hits	292	Shared Neighborhood Hits	65
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

TNI3K_HUMAN
NC score	0.050859 (rank : 847)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	537	Target Neighborhood Hits	1084	Shared Neighborhood Hits	60
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

BMR1B_HUMAN
NC score	0.050851 (rank : 848)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	537	Target Neighborhood Hits	760	Shared Neighborhood Hits	42
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

IRAK1_HUMAN
NC score	0.050315 (rank : 849)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	537	Target Neighborhood Hits	820	Shared Neighborhood Hits	47
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

BMR1A_MOUSE
NC score	0.050229 (rank : 850)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	537	Target Neighborhood Hits	758	Shared Neighborhood Hits	45
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1A_HUMAN
NC score	0.050074 (rank : 851)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	537	Target Neighborhood Hits	759	Shared Neighborhood Hits	45
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

CSKP_HUMAN
NC score	0.048547 (rank : 852)	θ value	0.0736092 (rank : 314)
Query Neighborhood Hits	537	Target Neighborhood Hits	1022	Shared Neighborhood Hits	124
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DOCK2_HUMAN
NC score	0.048240 (rank : 853)	θ value	2.36792 (rank : 451)
Query Neighborhood Hits	537	Target Neighborhood Hits	90	Shared Neighborhood Hits	43
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

CSKP_MOUSE
NC score	0.048177 (rank : 854)	θ value	0.125558 (rank : 338)
Query Neighborhood Hits	537	Target Neighborhood Hits	1027	Shared Neighborhood Hits	130
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DEK_HUMAN
NC score	0.042919 (rank : 855)	θ value	0.0961366 (rank : 325)
Query Neighborhood Hits	537	Target Neighborhood Hits	199	Shared Neighborhood Hits	18
SwissProt Accessions	P35659, Q5TGV4, Q5TGV5	Gene names	DEK
Domain Architecture	No domain graphic available
Description	Protein DEK.

CSKI1_MOUSE
NC score	0.039765 (rank : 856)	θ value	0.00228821 (rank : 242)
Query Neighborhood Hits	537	Target Neighborhood Hits	1031	Shared Neighborhood Hits	69
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

PLCB4_HUMAN
NC score	0.039060 (rank : 857)	θ value	5.27518 (rank : 493)
Query Neighborhood Hits	537	Target Neighborhood Hits	658	Shared Neighborhood Hits	44
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

CSKI1_HUMAN
NC score	0.038665 (rank : 858)	θ value	0.0148317 (rank : 286)
Query Neighborhood Hits	537	Target Neighborhood Hits	997	Shared Neighborhood Hits	70
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DLG4_MOUSE
NC score	0.038403 (rank : 859)	θ value	4.03905 (rank : 474)
Query Neighborhood Hits	537	Target Neighborhood Hits	282	Shared Neighborhood Hits	65
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

NPBL_MOUSE
NC score	0.036863 (rank : 860)	θ value	0.21417 (rank : 358)
Query Neighborhood Hits	537	Target Neighborhood Hits	1041	Shared Neighborhood Hits	56
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

CYLC1_HUMAN
NC score	0.033159 (rank : 861)	θ value	1.38821 (rank : 423)
Query Neighborhood Hits	537	Target Neighborhood Hits	408	Shared Neighborhood Hits	28
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

MRCKB_MOUSE
NC score	0.033154 (rank : 862)	θ value	5.27518 (rank : 490)
Query Neighborhood Hits	537	Target Neighborhood Hits	2180	Shared Neighborhood Hits	123
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NIPBL_HUMAN
NC score	0.032847 (rank : 863)	θ value	0.0252991 (rank : 292)
Query Neighborhood Hits	537	Target Neighborhood Hits	1311	Shared Neighborhood Hits	69
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

STK10_HUMAN
NC score	0.031887 (rank : 864)	θ value	5.27518 (rank : 495)
Query Neighborhood Hits	537	Target Neighborhood Hits	1921	Shared Neighborhood Hits	102
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CSKI2_HUMAN
NC score	0.031188 (rank : 865)	θ value	8.99809 (rank : 520)
Query Neighborhood Hits	537	Target Neighborhood Hits	747	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

SFR11_HUMAN
NC score	0.030671 (rank : 866)	θ value	3.0926 (rank : 465)
Query Neighborhood Hits	537	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q05519	Gene names	SFRS11
Domain Architecture
Description	Splicing factor arginine/serine-rich 11 (Arginine-rich 54 kDa nuclear protein) (p54).

RUFY2_HUMAN
NC score	0.030294 (rank : 867)	θ value	0.000270298 (rank : 175)
Query Neighborhood Hits	537	Target Neighborhood Hits	1208	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

T2FA_HUMAN
NC score	0.029090 (rank : 868)	θ value	3.0926 (rank : 467)
Query Neighborhood Hits	537	Target Neighborhood Hits	228	Shared Neighborhood Hits	19
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

NBN_HUMAN
NC score	0.027794 (rank : 869)	θ value	0.365318 (rank : 372)
Query Neighborhood Hits	537	Target Neighborhood Hits	226	Shared Neighborhood Hits	20
SwissProt Accessions	O60934, O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2	Gene names	NBN, NBS, NBS1, P95
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95).

ERC2_MOUSE
NC score	0.027692 (rank : 870)	θ value	1.06291 (rank : 412)
Query Neighborhood Hits	537	Target Neighborhood Hits	1166	Shared Neighborhood Hits	63
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

CEP35_HUMAN
NC score	0.027234 (rank : 871)	θ value	0.813845 (rank : 398)
Query Neighborhood Hits	537	Target Neighborhood Hits	811	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CLK3_MOUSE
NC score	0.026829 (rank : 872)	θ value	8.99809 (rank : 519)
Query Neighborhood Hits	537	Target Neighborhood Hits	761	Shared Neighborhood Hits	50
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_HUMAN
NC score	0.026779 (rank : 873)	θ value	8.99809 (rank : 518)
Query Neighborhood Hits	537	Target Neighborhood Hits	748	Shared Neighborhood Hits	49
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

ERC2_HUMAN
NC score	0.025933 (rank : 874)	θ value	1.38821 (rank : 425)
Query Neighborhood Hits	537	Target Neighborhood Hits	1156	Shared Neighborhood Hits	60
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

MRCKG_HUMAN
NC score	0.025763 (rank : 875)	θ value	1.38821 (rank : 429)
Query Neighborhood Hits	537	Target Neighborhood Hits	1519	Shared Neighborhood Hits	90
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

ZC11A_MOUSE
NC score	0.025311 (rank : 876)	θ value	0.163984 (rank : 355)
Query Neighborhood Hits	537	Target Neighborhood Hits	216	Shared Neighborhood Hits	9
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

CEP63_HUMAN
NC score	0.025076 (rank : 877)	θ value	1.81305 (rank : 435)
Query Neighborhood Hits	537	Target Neighborhood Hits	1005	Shared Neighborhood Hits	55
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

MAP1B_MOUSE
NC score	0.024961 (rank : 878)	θ value	8.99809 (rank : 528)
Query Neighborhood Hits	537	Target Neighborhood Hits	977	Shared Neighborhood Hits	72
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

CT194_HUMAN
NC score	0.024395 (rank : 879)	θ value	0.365318 (rank : 369)
Query Neighborhood Hits	537	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TEA3, Q66K86, Q6P2R9, Q9UFX9	Gene names	C20orf194
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf194.

PASK_MOUSE
NC score	0.023587 (rank : 880)	θ value	3.0926 (rank : 463)
Query Neighborhood Hits	537	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

KMHN1_MOUSE
NC score	0.023168 (rank : 881)	θ value	1.06291 (rank : 415)
Query Neighborhood Hits	537	Target Neighborhood Hits	949	Shared Neighborhood Hits	64
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

TXND2_MOUSE
NC score	0.023032 (rank : 882)	θ value	0.0252991 (rank : 293)
Query Neighborhood Hits	537	Target Neighborhood Hits	828	Shared Neighborhood Hits	39
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

GOGA4_HUMAN
NC score	0.022399 (rank : 883)	θ value	1.06291 (rank : 413)
Query Neighborhood Hits	537	Target Neighborhood Hits	2034	Shared Neighborhood Hits	96
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

RUFY2_MOUSE
NC score	0.022237 (rank : 884)	θ value	4.03905 (rank : 480)
Query Neighborhood Hits	537	Target Neighborhood Hits	820	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

CK5P2_HUMAN
NC score	0.022192 (rank : 885)	θ value	1.06291 (rank : 411)
Query Neighborhood Hits	537	Target Neighborhood Hits	1433	Shared Neighborhood Hits	81
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

IFT74_HUMAN
NC score	0.021840 (rank : 886)	θ value	3.0926 (rank : 460)
Query Neighborhood Hits	537	Target Neighborhood Hits	949	Shared Neighborhood Hits	53
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IWS1_MOUSE
NC score	0.020800 (rank : 887)	θ value	2.36792 (rank : 452)
Query Neighborhood Hits	537	Target Neighborhood Hits	1258	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

INVO_MOUSE
NC score	0.020163 (rank : 888)	θ value	8.99809 (rank : 524)
Query Neighborhood Hits	537	Target Neighborhood Hits	474	Shared Neighborhood Hits	30
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

CCD21_HUMAN
NC score	0.020090 (rank : 889)	θ value	8.99809 (rank : 517)
Query Neighborhood Hits	537	Target Neighborhood Hits	1228	Shared Neighborhood Hits	66
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

ANK2_HUMAN
NC score	0.019152 (rank : 890)	θ value	4.03905 (rank : 470)
Query Neighborhood Hits	537	Target Neighborhood Hits	1615	Shared Neighborhood Hits	86
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

RIF1_HUMAN
NC score	0.017979 (rank : 891)	θ value	2.36792 (rank : 455)
Query Neighborhood Hits	537	Target Neighborhood Hits	320	Shared Neighborhood Hits	27
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

CF060_HUMAN
NC score	0.017979 (rank : 892)	θ value	2.36792 (rank : 450)
Query Neighborhood Hits	537	Target Neighborhood Hits	1270	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

AT2B2_MOUSE
NC score	0.017944 (rank : 893)	θ value	0.279714 (rank : 362)
Query Neighborhood Hits	537	Target Neighborhood Hits	68	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0K7, O88863	Gene names	Atp2b2, Pmca2
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2) (Plasma membrane calcium pump isoform 2) (Plasma membrane calcium ATPase isoform 2).

SGP50_MOUSE
NC score	0.017679 (rank : 894)	θ value	6.88961 (rank : 513)
Query Neighborhood Hits	537	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q02596	Gene names	Glycam1
Domain Architecture
Description	Sulfated 50 kDa glycoprotein precursor (SGP50) (Endothelial ligand FOR L-selectin) (Glycosylation-dependent cell adhesion molecule 1) (GlyCAM-1) (MC26).

AT2B2_HUMAN
NC score	0.017485 (rank : 895)	θ value	0.813845 (rank : 397)
Query Neighborhood Hits	537	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q01814, O00766, Q12994, Q16818	Gene names	ATP2B2, PMCA2
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 2 (EC 3.6.3.8) (PMCA2) (Plasma membrane calcium pump isoform 2) (Plasma membrane calcium ATPase isoform 2).

MLL3_HUMAN
NC score	0.017380 (rank : 896)	θ value	0.365318 (rank : 371)
Query Neighborhood Hits	537	Target Neighborhood Hits	1644	Shared Neighborhood Hits	75
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

CP135_HUMAN
NC score	0.017342 (rank : 897)	θ value	6.88961 (rank : 503)
Query Neighborhood Hits	537	Target Neighborhood Hits	1290	Shared Neighborhood Hits	60
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

KINH_HUMAN
NC score	0.016947 (rank : 898)	θ value	5.27518 (rank : 489)
Query Neighborhood Hits	537	Target Neighborhood Hits	1231	Shared Neighborhood Hits	64
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

KIF5C_HUMAN
NC score	0.016852 (rank : 899)	θ value	8.99809 (rank : 525)
Query Neighborhood Hits	537	Target Neighborhood Hits	974	Shared Neighborhood Hits	57
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

AT2B3_HUMAN
NC score	0.016741 (rank : 900)	θ value	0.62314 (rank : 390)
Query Neighborhood Hits	537	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q16720, Q12995, Q16858	Gene names	ATP2B3
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 3 (EC 3.6.3.8) (PMCA3) (Plasma membrane calcium pump isoform 3) (Plasma membrane calcium ATPase isoform 3).

KI67_HUMAN
NC score	0.016245 (rank : 901)	θ value	5.27518 (rank : 488)
Query Neighborhood Hits	537	Target Neighborhood Hits	581	Shared Neighborhood Hits	35
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

RAPH1_HUMAN
NC score	0.016073 (rank : 902)	θ value	6.88961 (rank : 510)
Query Neighborhood Hits	537	Target Neighborhood Hits	593	Shared Neighborhood Hits	39
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

GABP2_HUMAN
NC score	0.016045 (rank : 903)	θ value	3.0926 (rank : 458)
Query Neighborhood Hits	537	Target Neighborhood Hits	454	Shared Neighborhood Hits	25
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
NC score	0.016010 (rank : 904)	θ value	4.03905 (rank : 475)
Query Neighborhood Hits	537	Target Neighborhood Hits	429	Shared Neighborhood Hits	25
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ERG_HUMAN
NC score	0.015716 (rank : 905)	θ value	0.125558 (rank : 340)
Query Neighborhood Hits	537	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	P11308, Q16113	Gene names	ERG
Domain Architecture
Description	Transcriptional regulator ERG (Transforming protein ERG).

AT2B1_HUMAN
NC score	0.015533 (rank : 906)	θ value	2.36792 (rank : 448)
Query Neighborhood Hits	537	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082	Gene names	ATP2B1, PMCA1
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 1 (EC 3.6.3.8) (PMCA1) (Plasma membrane calcium pump isoform 1) (Plasma membrane calcium ATPase isoform 1).

KIF5C_MOUSE
NC score	0.015439 (rank : 907)	θ value	8.99809 (rank : 526)
Query Neighborhood Hits	537	Target Neighborhood Hits	1040	Shared Neighborhood Hits	56
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

CASC5_MOUSE
NC score	0.014832 (rank : 908)	θ value	2.36792 (rank : 449)
Query Neighborhood Hits	537	Target Neighborhood Hits	70	Shared Neighborhood Hits	7
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

AP3D1_HUMAN
NC score	0.014540 (rank : 909)	θ value	2.36792 (rank : 446)
Query Neighborhood Hits	537	Target Neighborhood Hits	254	Shared Neighborhood Hits	20
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

SFR16_HUMAN
NC score	0.014457 (rank : 910)	θ value	8.99809 (rank : 534)
Query Neighborhood Hits	537	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N2M8, O96026, Q6UW71, Q96DX2	Gene names	SFRS16, SWAP2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2).

MORC3_HUMAN
NC score	0.014209 (rank : 911)	θ value	3.0926 (rank : 462)
Query Neighborhood Hits	537	Target Neighborhood Hits	489	Shared Neighborhood Hits	31
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

RFC1_MOUSE
NC score	0.013471 (rank : 912)	θ value	4.03905 (rank : 479)
Query Neighborhood Hits	537	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

MADCA_HUMAN
NC score	0.013426 (rank : 913)	θ value	6.88961 (rank : 508)
Query Neighborhood Hits	537	Target Neighborhood Hits	221	Shared Neighborhood Hits	15
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

FANCJ_MOUSE
NC score	0.012853 (rank : 914)	θ value	1.38821 (rank : 427)
Query Neighborhood Hits	537	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SXJ3, Q8BJQ8, Q8BKI6	Gene names	Brip1, Bach1, Fancj
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

ZN638_HUMAN
NC score	0.012656 (rank : 915)	θ value	1.81305 (rank : 444)
Query Neighborhood Hits	537	Target Neighborhood Hits	343	Shared Neighborhood Hits	23
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

BID_MOUSE
NC score	0.012257 (rank : 916)	θ value	6.88961 (rank : 501)
Query Neighborhood Hits	537	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	P70444, Q99M39	Gene names	Bid
Domain Architecture
Description	BH3-interacting domain death agonist (BID) (p22 BID) [Contains: BH3- interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)].

ERG_MOUSE
NC score	0.012136 (rank : 917)	θ value	1.38821 (rank : 426)
Query Neighborhood Hits	537	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	P81270, Q8C5L4, Q920K7, Q920K8, Q920K9	Gene names	Erg, Erg-3
Domain Architecture
Description	Transcriptional regulator ERG.

TNR6A_HUMAN
NC score	0.011545 (rank : 918)	θ value	8.99809 (rank : 535)
Query Neighborhood Hits	537	Target Neighborhood Hits	343	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

HIP1_HUMAN
NC score	0.010993 (rank : 919)	θ value	6.88961 (rank : 506)
Query Neighborhood Hits	537	Target Neighborhood Hits	1016	Shared Neighborhood Hits	49
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

TOP2B_HUMAN
NC score	0.010917 (rank : 920)	θ value	1.81305 (rank : 440)
Query Neighborhood Hits	537	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q02880, Q13600, Q9UMG8, Q9UQP8	Gene names	TOP2B
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

PRG4_MOUSE
NC score	0.010701 (rank : 921)	θ value	6.88961 (rank : 509)
Query Neighborhood Hits	537	Target Neighborhood Hits	624	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

DPOLZ_MOUSE
NC score	0.010677 (rank : 922)	θ value	3.0926 (rank : 457)
Query Neighborhood Hits	537	Target Neighborhood Hits	169	Shared Neighborhood Hits	11
SwissProt Accessions	Q61493, Q9JMD6, Q9QWX6	Gene names	Rev3l, Polz, Sez4
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Seizure-related protein 4).

K0513_MOUSE
NC score	0.010590 (rank : 923)	θ value	5.27518 (rank : 487)
Query Neighborhood Hits	537	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R0A7, Q80TY8, Q8BQV3, Q8C8N9, Q8CCN0	Gene names	Kiaa0513
Domain Architecture	No domain graphic available
Description	Protein KIAA0513.

E41L2_HUMAN
NC score	0.010293 (rank : 924)	θ value	0.0961366 (rank : 328)
Query Neighborhood Hits	537	Target Neighborhood Hits	287	Shared Neighborhood Hits	15
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

MYBB_HUMAN
NC score	0.009947 (rank : 925)	θ value	2.36792 (rank : 453)
Query Neighborhood Hits	537	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	P10244	Gene names	MYBL2, BMYB
Domain Architecture
Description	Myb-related protein B (B-Myb).

HTSF1_HUMAN
NC score	0.009908 (rank : 926)	θ value	8.99809 (rank : 522)
Query Neighborhood Hits	537	Target Neighborhood Hits	408	Shared Neighborhood Hits	22
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

NPM_MOUSE
NC score	0.009816 (rank : 927)	θ value	5.27518 (rank : 492)
Query Neighborhood Hits	537	Target Neighborhood Hits	69	Shared Neighborhood Hits	8
SwissProt Accessions	Q61937	Gene names	Npm1
Domain Architecture
Description	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38).

CCD16_MOUSE
NC score	0.009742 (rank : 928)	θ value	6.88961 (rank : 502)
Query Neighborhood Hits	537	Target Neighborhood Hits	218	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R1N0, Q3TR52, Q9CWV9, Q9CYI6	Gene names	Ccdc16, Omcg1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 16 (Ovus mutant candidate gene 1 protein).

K0586_HUMAN
NC score	0.009493 (rank : 929)	θ value	6.88961 (rank : 507)
Query Neighborhood Hits	537	Target Neighborhood Hits	311	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

PACS1_MOUSE
NC score	0.008879 (rank : 930)	θ value	8.99809 (rank : 532)
Query Neighborhood Hits	537	Target Neighborhood Hits	87	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K212, Q6P5H8	Gene names	Pacs1
Domain Architecture	No domain graphic available
Description	Phosphofurin acidic cluster sorting protein 1 (PACS-1).

MBP_HUMAN
NC score	0.008619 (rank : 931)	θ value	8.99809 (rank : 529)
Query Neighborhood Hits	537	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	P02686, Q15337, Q15338, Q15339, Q15340, Q6AI64, Q6FH37, Q6FI04, Q6PK23	Gene names	MBP
Domain Architecture
Description	Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein).

UBP36_HUMAN
NC score	0.008207 (rank : 932)	θ value	1.06291 (rank : 422)
Query Neighborhood Hits	537	Target Neighborhood Hits	232	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

PACS1_HUMAN
NC score	0.008133 (rank : 933)	θ value	8.99809 (rank : 531)
Query Neighborhood Hits	537	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q6VY07, Q6PJY6, Q6PKB6, Q7Z590, Q7Z5W4, Q8N8K6, Q96MW0, Q9NW92, Q9ULP5	Gene names	PACS1, KIAA1175
Domain Architecture	No domain graphic available
Description	Phosphofurin acidic cluster sorting protein 1 (PACS-1).

HDAC1_HUMAN
NC score	0.007842 (rank : 934)	θ value	3.0926 (rank : 459)
Query Neighborhood Hits	537	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q13547, Q92534	Gene names	HDAC1, RPD3L1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

HDAC1_MOUSE
NC score	0.007278 (rank : 935)	θ value	4.03905 (rank : 476)
Query Neighborhood Hits	537	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O09106, P97476	Gene names	Hdac1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

DCR1C_MOUSE
NC score	0.007192 (rank : 936)	θ value	6.88961 (rank : 505)
Query Neighborhood Hits	537	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4J0, Q8BG72, Q8BTT1	Gene names	Dclre1c, Art, Snm1l
Domain Architecture	No domain graphic available
Description	Artemis protein (EC 3.1.-.-) (DNA cross-link repair 1C protein) (mArt protein) (SNM1-like protein).

RPGR_HUMAN
NC score	0.006528 (rank : 937)	θ value	5.27518 (rank : 494)
Query Neighborhood Hits	537	Target Neighborhood Hits	279	Shared Neighborhood Hits	20
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

BRCA2_HUMAN
NC score	0.005737 (rank : 938)	θ value	8.99809 (rank : 516)
Query Neighborhood Hits	537	Target Neighborhood Hits	202	Shared Neighborhood Hits	13
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

GTF2I_HUMAN
NC score	0.004953 (rank : 939)	θ value	8.99809 (rank : 521)
Query Neighborhood Hits	537	Target Neighborhood Hits	151	Shared Neighborhood Hits	8
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

LEO1_HUMAN
NC score	0.004280 (rank : 940)	θ value	8.99809 (rank : 527)
Query Neighborhood Hits	537	Target Neighborhood Hits	958	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

CUL4B_HUMAN
NC score	0.004263 (rank : 941)	θ value	4.03905 (rank : 472)
Query Neighborhood Hits	537	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

HUWE1_HUMAN
NC score	0.003497 (rank : 942)	θ value	8.99809 (rank : 523)
Query Neighborhood Hits	537	Target Neighborhood Hits	443	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

EAA3_HUMAN
NC score	0.003157 (rank : 943)	θ value	5.27518 (rank : 485)
Query Neighborhood Hits	537	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P43005, O75587, Q5VZ24, Q8N199, Q9UEW2	Gene names	SLC1A1, EAAC1, EAAT3
Domain Architecture
Description	Excitatory amino acid transporter 3 (Sodium-dependent glutamate/aspartate transporter 3) (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter).

TRI25_MOUSE
NC score	0.001281 (rank : 944)	θ value	5.27518 (rank : 498)
Query Neighborhood Hits	537	Target Neighborhood Hits	446	Shared Neighborhood Hits	17
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

ADA30_HUMAN
NC score	0.001177 (rank : 945)	θ value	2.36792 (rank : 445)
Query Neighborhood Hits	537	Target Neighborhood Hits	391	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

PCSK5_MOUSE
NC score	-0.004578 (rank : 946)	θ value	3.0926 (rank : 464)
Query Neighborhood Hits	537	Target Neighborhood Hits	613	Shared Neighborhood Hits	3
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

FOG1_MOUSE
NC score	-0.005315 (rank : 947)	θ value	0.0961366 (rank : 329)
Query Neighborhood Hits	537	Target Neighborhood Hits	1237	Shared Neighborhood Hits	25
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ATBF1_MOUSE
NC score	-0.009680 (rank : 948)	θ value	6.88961 (rank : 500)
Query Neighborhood Hits	537	Target Neighborhood Hits	1841	Shared Neighborhood Hits	48
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ACM2_HUMAN
NC score	-0.012828 (rank : 949)	θ value	4.03905 (rank : 469)
Query Neighborhood Hits	537	Target Neighborhood Hits	930	Shared Neighborhood Hits	5
SwissProt Accessions	P08172, Q9P1X9	Gene names	CHRM2
Domain Architecture
Description	Muscarinic acetylcholine receptor M2.

ACM2_MOUSE
NC score	-0.013185 (rank : 950)	θ value	5.27518 (rank : 483)
Query Neighborhood Hits	537	Target Neighborhood Hits	905	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ERZ4	Gene names	Chrm2, Chrm-2
Domain Architecture
Description	Muscarinic acetylcholine receptor M2.

ZFP3_HUMAN
NC score	-0.015466 (rank : 951)	θ value	6.88961 (rank : 515)
Query Neighborhood Hits	537	Target Neighborhood Hits	750	Shared Neighborhood Hits	5
SwissProt Accessions	Q96NJ6	Gene names	ZFP3
Domain Architecture	No domain graphic available
Description	Zinc finger protein 3 homolog (Zfp-3).