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Network neighborhood for query Sequence : FGD3_MOUSE

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FGD3_MOUSE
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD3_HUMAN
θ value	0 (rank : 1)	NC score	0.978640 (rank : 2)
Query Neighborhood Hits	257	Target Neighborhood Hits	249	Shared Neighborhood Hits	148
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	257	Target Neighborhood Hits	257	Shared Neighborhood Hits	257
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD1_HUMAN
θ value	1.72687e-168 (rank : 3)	NC score	0.945251 (rank : 7)
Query Neighborhood Hits	257	Target Neighborhood Hits	367	Shared Neighborhood Hits	134
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	3.25673e-167 (rank : 4)	NC score	0.944171 (rank : 8)
Query Neighborhood Hits	257	Target Neighborhood Hits	387	Shared Neighborhood Hits	135
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD4_HUMAN
θ value	1.02182e-136 (rank : 5)	NC score	0.952578 (rank : 4)
Query Neighborhood Hits	257	Target Neighborhood Hits	219	Shared Neighborhood Hits	126
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	2.27638e-136 (rank : 6)	NC score	0.952316 (rank : 5)
Query Neighborhood Hits	257	Target Neighborhood Hits	227	Shared Neighborhood Hits	126
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD2_HUMAN
θ value	7.10925e-122 (rank : 7)	NC score	0.955435 (rank : 3)
Query Neighborhood Hits	257	Target Neighborhood Hits	151	Shared Neighborhood Hits	126
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	5.09482e-120 (rank : 8)	NC score	0.951230 (rank : 6)
Query Neighborhood Hits	257	Target Neighborhood Hits	163	Shared Neighborhood Hits	124
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD6_MOUSE
θ value	2.84797e-54 (rank : 9)	NC score	0.861954 (rank : 9)
Query Neighborhood Hits	257	Target Neighborhood Hits	282	Shared Neighborhood Hits	118
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
θ value	3.48141e-52 (rank : 10)	NC score	0.860615 (rank : 10)
Query Neighborhood Hits	257	Target Neighborhood Hits	237	Shared Neighborhood Hits	117
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
θ value	3.05695e-40 (rank : 11)	NC score	0.785498 (rank : 11)
Query Neighborhood Hits	257	Target Neighborhood Hits	235	Shared Neighborhood Hits	106
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	1.08726e-37 (rank : 12)	NC score	0.777622 (rank : 12)
Query Neighborhood Hits	257	Target Neighborhood Hits	170	Shared Neighborhood Hits	104
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP2_MOUSE
θ value	5.06226e-27 (rank : 13)	NC score	0.575865 (rank : 36)
Query Neighborhood Hits	257	Target Neighborhood Hits	209	Shared Neighborhood Hits	92
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	3.28125e-26 (rank : 14)	NC score	0.553170 (rank : 44)
Query Neighborhood Hits	257	Target Neighborhood Hits	240	Shared Neighborhood Hits	88
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PREX1_HUMAN
θ value	1.37858e-24 (rank : 15)	NC score	0.758253 (rank : 13)
Query Neighborhood Hits	257	Target Neighborhood Hits	177	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FARP1_HUMAN
θ value	8.93572e-24 (rank : 16)	NC score	0.523532 (rank : 51)
Query Neighborhood Hits	257	Target Neighborhood Hits	241	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

DUET_HUMAN
θ value	1.6852e-22 (rank : 17)	NC score	0.237939 (rank : 94)
Query Neighborhood Hits	257	Target Neighborhood Hits	1220	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
θ value	4.58923e-20 (rank : 18)	NC score	0.230447 (rank : 98)
Query Neighborhood Hits	257	Target Neighborhood Hits	1580	Shared Neighborhood Hits	99
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ARHG4_HUMAN
θ value	1.33526e-19 (rank : 19)	NC score	0.674015 (rank : 18)
Query Neighborhood Hits	257	Target Neighborhood Hits	242	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	1.74391e-19 (rank : 20)	NC score	0.688925 (rank : 17)
Query Neighborhood Hits	257	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ECT2_MOUSE
θ value	6.20254e-17 (rank : 21)	NC score	0.748073 (rank : 14)
Query Neighborhood Hits	257	Target Neighborhood Hits	98	Shared Neighborhood Hits	73
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

HAPIP_HUMAN
θ value	8.10077e-17 (rank : 22)	NC score	0.561826 (rank : 40)
Query Neighborhood Hits	257	Target Neighborhood Hits	350	Shared Neighborhood Hits	81
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

PKHG1_HUMAN
θ value	1.058e-16 (rank : 23)	NC score	0.719060 (rank : 16)
Query Neighborhood Hits	257	Target Neighborhood Hits	174	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ECT2_HUMAN
θ value	2.35696e-16 (rank : 24)	NC score	0.733669 (rank : 15)
Query Neighborhood Hits	257	Target Neighborhood Hits	98	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VAV2_MOUSE
θ value	3.07829e-16 (rank : 25)	NC score	0.492287 (rank : 57)
Query Neighborhood Hits	257	Target Neighborhood Hits	456	Shared Neighborhood Hits	79
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ITSN1_MOUSE
θ value	4.02038e-16 (rank : 26)	NC score	0.409573 (rank : 73)
Query Neighborhood Hits	257	Target Neighborhood Hits	1669	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
θ value	8.95645e-16 (rank : 27)	NC score	0.410077 (rank : 72)
Query Neighborhood Hits	257	Target Neighborhood Hits	1757	Shared Neighborhood Hits	105
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NGEF_HUMAN
θ value	1.52774e-15 (rank : 28)	NC score	0.652927 (rank : 21)
Query Neighborhood Hits	257	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	1.52774e-15 (rank : 29)	NC score	0.640051 (rank : 24)
Query Neighborhood Hits	257	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

VAV2_HUMAN
θ value	3.40345e-15 (rank : 30)	NC score	0.484962 (rank : 60)
Query Neighborhood Hits	257	Target Neighborhood Hits	453	Shared Neighborhood Hits	77
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	5.8054e-15 (rank : 31)	NC score	0.479471 (rank : 62)
Query Neighborhood Hits	257	Target Neighborhood Hits	398	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	7.58209e-15 (rank : 32)	NC score	0.481809 (rank : 61)
Query Neighborhood Hits	257	Target Neighborhood Hits	404	Shared Neighborhood Hits	74
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ITSN2_HUMAN
θ value	1.29331e-14 (rank : 33)	NC score	0.442072 (rank : 67)
Query Neighborhood Hits	257	Target Neighborhood Hits	1173	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHG2_HUMAN
θ value	2.20605e-14 (rank : 34)	NC score	0.561352 (rank : 41)
Query Neighborhood Hits	257	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	6.41864e-14 (rank : 35)	NC score	0.608261 (rank : 29)
Query Neighborhood Hits	257	Target Neighborhood Hits	120	Shared Neighborhood Hits	66
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG1_MOUSE
θ value	1.42992e-13 (rank : 36)	NC score	0.564919 (rank : 39)
Query Neighborhood Hits	257	Target Neighborhood Hits	266	Shared Neighborhood Hits	68
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG5_HUMAN
θ value	5.43371e-13 (rank : 37)	NC score	0.661545 (rank : 19)
Query Neighborhood Hits	257	Target Neighborhood Hits	172	Shared Neighborhood Hits	70
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ITSN2_MOUSE
θ value	9.26847e-13 (rank : 38)	NC score	0.418458 (rank : 70)
Query Neighborhood Hits	257	Target Neighborhood Hits	1371	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG9_HUMAN
θ value	2.69671e-12 (rank : 39)	NC score	0.653057 (rank : 20)
Query Neighborhood Hits	257	Target Neighborhood Hits	235	Shared Neighborhood Hits	71
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	3.52202e-12 (rank : 40)	NC score	0.651644 (rank : 22)
Query Neighborhood Hits	257	Target Neighborhood Hits	234	Shared Neighborhood Hits	71
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	4.59992e-12 (rank : 41)	NC score	0.623654 (rank : 26)
Query Neighborhood Hits	257	Target Neighborhood Hits	187	Shared Neighborhood Hits	67
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	4.59992e-12 (rank : 42)	NC score	0.620295 (rank : 27)
Query Neighborhood Hits	257	Target Neighborhood Hits	125	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

OBSCN_HUMAN
θ value	7.84624e-12 (rank : 43)	NC score	0.113242 (rank : 123)
Query Neighborhood Hits	257	Target Neighborhood Hits	1931	Shared Neighborhood Hits	82
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ABR_HUMAN
θ value	1.02475e-11 (rank : 44)	NC score	0.435938 (rank : 68)
Query Neighborhood Hits	257	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

GNRP_HUMAN
θ value	1.02475e-11 (rank : 45)	NC score	0.493849 (rank : 56)
Query Neighborhood Hits	257	Target Neighborhood Hits	239	Shared Neighborhood Hits	72
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

MCF2L_MOUSE
θ value	1.33837e-11 (rank : 46)	NC score	0.603387 (rank : 30)
Query Neighborhood Hits	257	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

VAV_MOUSE
θ value	1.74796e-11 (rank : 47)	NC score	0.494931 (rank : 55)
Query Neighborhood Hits	257	Target Neighborhood Hits	430	Shared Neighborhood Hits	73
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG1_HUMAN
θ value	2.98157e-11 (rank : 48)	NC score	0.590707 (rank : 33)
Query Neighborhood Hits	257	Target Neighborhood Hits	176	Shared Neighborhood Hits	70
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

BCR_HUMAN
θ value	2.98157e-11 (rank : 49)	NC score	0.434823 (rank : 69)
Query Neighborhood Hits	257	Target Neighborhood Hits	204	Shared Neighborhood Hits	63
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

GNRP_MOUSE
θ value	2.98157e-11 (rank : 50)	NC score	0.527205 (rank : 50)
Query Neighborhood Hits	257	Target Neighborhood Hits	191	Shared Neighborhood Hits	76
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGB_HUMAN
θ value	1.133e-10 (rank : 51)	NC score	0.561079 (rank : 42)
Query Neighborhood Hits	257	Target Neighborhood Hits	375	Shared Neighborhood Hits	72
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

LBC_HUMAN
θ value	1.47974e-10 (rank : 52)	NC score	0.574274 (rank : 37)
Query Neighborhood Hits	257	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

VAV_HUMAN
θ value	1.9326e-10 (rank : 53)	NC score	0.486205 (rank : 59)
Query Neighborhood Hits	257	Target Neighborhood Hits	452	Shared Neighborhood Hits	73
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG6_HUMAN
θ value	4.30538e-10 (rank : 54)	NC score	0.416003 (rank : 71)
Query Neighborhood Hits	257	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

MCF2_HUMAN
θ value	4.30538e-10 (rank : 55)	NC score	0.636898 (rank : 25)
Query Neighborhood Hits	257	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGC_MOUSE
θ value	1.63604e-09 (rank : 56)	NC score	0.532095 (rank : 49)
Query Neighborhood Hits	257	Target Neighborhood Hits	344	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG3_MOUSE
θ value	2.79066e-09 (rank : 57)	NC score	0.586616 (rank : 34)
Query Neighborhood Hits	257	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
θ value	6.21693e-09 (rank : 58)	NC score	0.585725 (rank : 35)
Query Neighborhood Hits	257	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHGG_HUMAN
θ value	6.21693e-09 (rank : 59)	NC score	0.641181 (rank : 23)
Query Neighborhood Hits	257	Target Neighborhood Hits	129	Shared Neighborhood Hits	69
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGC_HUMAN
θ value	1.06045e-08 (rank : 60)	NC score	0.533705 (rank : 45)
Query Neighborhood Hits	257	Target Neighborhood Hits	351	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RUFY2_HUMAN
θ value	3.08544e-08 (rank : 61)	NC score	0.194418 (rank : 104)
Query Neighborhood Hits	257	Target Neighborhood Hits	1208	Shared Neighborhood Hits	76
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TIAM1_HUMAN
θ value	4.0297e-08 (rank : 62)	NC score	0.591600 (rank : 32)
Query Neighborhood Hits	257	Target Neighborhood Hits	225	Shared Neighborhood Hits	73
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	5.26297e-08 (rank : 63)	NC score	0.595371 (rank : 31)
Query Neighborhood Hits	257	Target Neighborhood Hits	205	Shared Neighborhood Hits	73
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

DNMBP_MOUSE
θ value	6.87365e-08 (rank : 64)	NC score	0.468944 (rank : 64)
Query Neighborhood Hits	257	Target Neighborhood Hits	435	Shared Neighborhood Hits	72
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EEA1_MOUSE
θ value	6.87365e-08 (rank : 65)	NC score	0.160589 (rank : 110)
Query Neighborhood Hits	257	Target Neighborhood Hits	1637	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RGNEF_MOUSE
θ value	6.87365e-08 (rank : 66)	NC score	0.448598 (rank : 66)
Query Neighborhood Hits	257	Target Neighborhood Hits	641	Shared Neighborhood Hits	84
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

PKHG4_HUMAN
θ value	8.97725e-08 (rank : 67)	NC score	0.533696 (rank : 46)
Query Neighborhood Hits	257	Target Neighborhood Hits	200	Shared Neighborhood Hits	64
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

EEA1_HUMAN
θ value	1.53129e-07 (rank : 68)	NC score	0.149935 (rank : 112)
Query Neighborhood Hits	257	Target Neighborhood Hits	1796	Shared Neighborhood Hits	92
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

DNMBP_HUMAN
θ value	3.41135e-07 (rank : 69)	NC score	0.450896 (rank : 65)
Query Neighborhood Hits	257	Target Neighborhood Hits	413	Shared Neighborhood Hits	77
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGG_MOUSE
θ value	5.81887e-07 (rank : 70)	NC score	0.619299 (rank : 28)
Query Neighborhood Hits	257	Target Neighborhood Hits	152	Shared Neighborhood Hits	67
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG7_MOUSE
θ value	9.92553e-07 (rank : 71)	NC score	0.474141 (rank : 63)
Query Neighborhood Hits	257	Target Neighborhood Hits	396	Shared Neighborhood Hits	70
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
θ value	1.69304e-06 (rank : 72)	NC score	0.491310 (rank : 58)
Query Neighborhood Hits	257	Target Neighborhood Hits	347	Shared Neighborhood Hits	74
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PKHF2_HUMAN
θ value	1.69304e-06 (rank : 73)	NC score	0.533150 (rank : 47)
Query Neighborhood Hits	257	Target Neighborhood Hits	75	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	1.69304e-06 (rank : 74)	NC score	0.532722 (rank : 48)
Query Neighborhood Hits	257	Target Neighborhood Hits	77	Shared Neighborhood Hits	62
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

SOS2_HUMAN
θ value	3.77169e-06 (rank : 75)	NC score	0.322127 (rank : 81)
Query Neighborhood Hits	257	Target Neighborhood Hits	193	Shared Neighborhood Hits	42
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

WDFY3_HUMAN
θ value	6.43352e-06 (rank : 76)	NC score	0.234827 (rank : 95)
Query Neighborhood Hits	257	Target Neighborhood Hits	348	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	6.43352e-06 (rank : 77)	NC score	0.234707 (rank : 96)
Query Neighborhood Hits	257	Target Neighborhood Hits	332	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ARHG8_HUMAN
θ value	1.09739e-05 (rank : 78)	NC score	0.572266 (rank : 38)
Query Neighborhood Hits	257	Target Neighborhood Hits	85	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SOS1_HUMAN
θ value	1.09739e-05 (rank : 79)	NC score	0.321792 (rank : 82)
Query Neighborhood Hits	257	Target Neighborhood Hits	274	Shared Neighborhood Hits	44
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	1.43324e-05 (rank : 80)	NC score	0.302821 (rank : 85)
Query Neighborhood Hits	257	Target Neighborhood Hits	281	Shared Neighborhood Hits	46
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ZFY16_HUMAN
θ value	1.43324e-05 (rank : 81)	NC score	0.383885 (rank : 78)
Query Neighborhood Hits	257	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

RUFY2_MOUSE
θ value	1.87187e-05 (rank : 82)	NC score	0.230669 (rank : 97)
Query Neighborhood Hits	257	Target Neighborhood Hits	820	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

ARHG8_MOUSE
θ value	2.44474e-05 (rank : 83)	NC score	0.509400 (rank : 54)
Query Neighborhood Hits	257	Target Neighborhood Hits	79	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

RBNS5_HUMAN
θ value	7.1131e-05 (rank : 84)	NC score	0.319481 (rank : 83)
Query Neighborhood Hits	257	Target Neighborhood Hits	242	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	7.1131e-05 (rank : 85)	NC score	0.315017 (rank : 84)
Query Neighborhood Hits	257	Target Neighborhood Hits	266	Shared Neighborhood Hits	57
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ZFY16_MOUSE
θ value	9.29e-05 (rank : 86)	NC score	0.390614 (rank : 76)
Query Neighborhood Hits	257	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

PKHF1_HUMAN
θ value	0.000270298 (rank : 87)	NC score	0.516792 (rank : 52)
Query Neighborhood Hits	257	Target Neighborhood Hits	76	Shared Neighborhood Hits	61
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

ZFYV9_HUMAN
θ value	0.00035302 (rank : 88)	NC score	0.401254 (rank : 75)
Query Neighborhood Hits	257	Target Neighborhood Hits	134	Shared Neighborhood Hits	52
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PKHF1_MOUSE
θ value	0.000461057 (rank : 89)	NC score	0.514413 (rank : 53)
Query Neighborhood Hits	257	Target Neighborhood Hits	80	Shared Neighborhood Hits	60
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

RUFY1_MOUSE
θ value	0.00175202 (rank : 90)	NC score	0.224928 (rank : 99)
Query Neighborhood Hits	257	Target Neighborhood Hits	765	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

HGS_MOUSE
θ value	0.00228821 (rank : 91)	NC score	0.302327 (rank : 86)
Query Neighborhood Hits	257	Target Neighborhood Hits	589	Shared Neighborhood Hits	67
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

RUFY1_HUMAN
θ value	0.00390308 (rank : 92)	NC score	0.220912 (rank : 100)
Query Neighborhood Hits	257	Target Neighborhood Hits	848	Shared Neighborhood Hits	74
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

ANFY1_HUMAN
θ value	0.00509761 (rank : 93)	NC score	0.144151 (rank : 115)
Query Neighborhood Hits	257	Target Neighborhood Hits	480	Shared Neighborhood Hits	58
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_MOUSE
θ value	0.00509761 (rank : 94)	NC score	0.144201 (rank : 114)
Query Neighborhood Hits	257	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

FYCO1_MOUSE
θ value	0.00665767 (rank : 95)	NC score	0.147885 (rank : 113)
Query Neighborhood Hits	257	Target Neighborhood Hits	1059	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

HGS_HUMAN
θ value	0.00869519 (rank : 96)	NC score	0.300964 (rank : 87)
Query Neighborhood Hits	257	Target Neighborhood Hits	517	Shared Neighborhood Hits	63
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

CENB5_HUMAN
θ value	0.0113563 (rank : 97)	NC score	0.045138 (rank : 271)
Query Neighborhood Hits	257	Target Neighborhood Hits	395	Shared Neighborhood Hits	27
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

FYCO1_HUMAN
θ value	0.0113563 (rank : 98)	NC score	0.158472 (rank : 111)
Query Neighborhood Hits	257	Target Neighborhood Hits	1149	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ZFY21_MOUSE
θ value	0.0113563 (rank : 99)	NC score	0.387641 (rank : 77)
Query Neighborhood Hits	257	Target Neighborhood Hits	72	Shared Neighborhood Hits	57
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	0.0113563 (rank : 100)	NC score	0.407125 (rank : 74)
Query Neighborhood Hits	257	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFY19_HUMAN
θ value	0.0148317 (rank : 101)	NC score	0.280874 (rank : 88)
Query Neighborhood Hits	257	Target Neighborhood Hits	206	Shared Neighborhood Hits	76
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

PKHA6_MOUSE
θ value	0.0193708 (rank : 102)	NC score	0.163891 (rank : 109)
Query Neighborhood Hits	257	Target Neighborhood Hits	591	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ALS2_MOUSE
θ value	0.0252991 (rank : 103)	NC score	0.126173 (rank : 117)
Query Neighborhood Hits	257	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ZFY19_MOUSE
θ value	0.0252991 (rank : 104)	NC score	0.272685 (rank : 89)
Query Neighborhood Hits	257	Target Neighborhood Hits	143	Shared Neighborhood Hits	61
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

PKHA6_HUMAN
θ value	0.0330416 (rank : 105)	NC score	0.167219 (rank : 108)
Query Neighborhood Hits	257	Target Neighborhood Hits	556	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

FYV1_HUMAN
θ value	0.0431538 (rank : 106)	NC score	0.249719 (rank : 92)
Query Neighborhood Hits	257	Target Neighborhood Hits	217	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	0.0431538 (rank : 107)	NC score	0.246146 (rank : 93)
Query Neighborhood Hits	257	Target Neighborhood Hits	191	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY27_MOUSE
θ value	0.0431538 (rank : 108)	NC score	0.181917 (rank : 106)
Query Neighborhood Hits	257	Target Neighborhood Hits	53	Shared Neighborhood Hits	42
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
θ value	0.0563607 (rank : 109)	NC score	0.174163 (rank : 107)
Query Neighborhood Hits	257	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

MTMR3_HUMAN
θ value	0.0736092 (rank : 110)	NC score	0.205128 (rank : 102)
Query Neighborhood Hits	257	Target Neighborhood Hits	163	Shared Neighborhood Hits	53
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

ZBT40_HUMAN
θ value	0.0736092 (rank : 111)	NC score	0.024037 (rank : 289)
Query Neighborhood Hits	257	Target Neighborhood Hits	949	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

SWP70_MOUSE
θ value	0.0961366 (rank : 112)	NC score	0.087095 (rank : 146)
Query Neighborhood Hits	257	Target Neighborhood Hits	1097	Shared Neighborhood Hits	60
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ZFY21_HUMAN
θ value	0.0961366 (rank : 113)	NC score	0.378584 (rank : 79)
Query Neighborhood Hits	257	Target Neighborhood Hits	72	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZN260_MOUSE
θ value	0.125558 (rank : 114)	NC score	0.020131 (rank : 305)
Query Neighborhood Hits	257	Target Neighborhood Hits	765	Shared Neighborhood Hits	64
SwissProt Accessions	Q62513, Q3U170, Q8C2Q6, Q9R2B4	Gene names	Znf260, Zfp260
Domain Architecture	No domain graphic available
Description	Zinc finger protein 260 (Zfp-260).

ZN418_HUMAN
θ value	0.125558 (rank : 115)	NC score	0.019995 (rank : 311)
Query Neighborhood Hits	257	Target Neighborhood Hits	776	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TF45, Q670L5, Q96N18	Gene names	ZNF418, KIAA1956
Domain Architecture
Description	Zinc finger protein 418.

OGFR_HUMAN
θ value	0.163984 (rank : 116)	NC score	0.038384 (rank : 275)
Query Neighborhood Hits	257	Target Neighborhood Hits	1582	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ZN260_HUMAN
θ value	0.163984 (rank : 117)	NC score	0.020119 (rank : 307)
Query Neighborhood Hits	257	Target Neighborhood Hits	757	Shared Neighborhood Hits	64
SwissProt Accessions	Q3ZCT1	Gene names	ZNF260, ZFP260
Domain Architecture	No domain graphic available
Description	Zinc finger protein 260 (Zfp-260).

RNF37_MOUSE
θ value	0.21417 (rank : 118)	NC score	0.036411 (rank : 276)
Query Neighborhood Hits	257	Target Neighborhood Hits	102	Shared Neighborhood Hits	6
SwissProt Accessions	Q925F4	Gene names	Ubox5, Rnf37, Ubce7ip5, Uip5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (UbcM4-interacting protein 5) (U-box domain-containing protein 5).

SWP70_HUMAN
θ value	0.21417 (rank : 119)	NC score	0.089155 (rank : 143)
Query Neighborhood Hits	257	Target Neighborhood Hits	973	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

WDFY1_HUMAN
θ value	0.21417 (rank : 120)	NC score	0.215319 (rank : 101)
Query Neighborhood Hits	257	Target Neighborhood Hits	305	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ZN502_HUMAN
θ value	0.21417 (rank : 121)	NC score	0.019765 (rank : 314)
Query Neighborhood Hits	257	Target Neighborhood Hits	762	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TBZ5	Gene names	ZNF502
Domain Architecture	No domain graphic available
Description	Zinc finger protein 502.

ZN333_HUMAN
θ value	0.279714 (rank : 122)	NC score	0.019637 (rank : 316)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	62
SwissProt Accessions	Q96JL9, Q8TDL0	Gene names	ZNF333, KIAA1806
Domain Architecture
Description	Zinc finger protein 333.

KPCG_HUMAN
θ value	0.365318 (rank : 123)	NC score	0.016491 (rank : 353)
Query Neighborhood Hits	257	Target Neighborhood Hits	1126	Shared Neighborhood Hits	43
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

ZN302_HUMAN
θ value	0.365318 (rank : 124)	NC score	0.019835 (rank : 313)
Query Neighborhood Hits	257	Target Neighborhood Hits	755	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR11, Q9BZD8, Q9P0J4	Gene names	ZNF302, ZNF135L, ZNF140L
Domain Architecture
Description	Zinc finger protein 302 (ZNF135-like) (ZNF140-like).

ZN678_HUMAN
θ value	0.365318 (rank : 125)	NC score	0.019578 (rank : 317)
Query Neighborhood Hits	257	Target Neighborhood Hits	761	Shared Neighborhood Hits	66
SwissProt Accessions	Q5SXM1, Q8IVQ9	Gene names	ZNF678
Domain Architecture	No domain graphic available
Description	Zinc finger protein 678.

DUS8_MOUSE
θ value	0.47712 (rank : 126)	NC score	0.011326 (rank : 365)
Query Neighborhood Hits	257	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	O09112	Gene names	Dusp8, Nttp1
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Neuronal tyrosine threonine phosphatase 1).

GOGA2_HUMAN
θ value	0.47712 (rank : 127)	NC score	0.033748 (rank : 279)
Query Neighborhood Hits	257	Target Neighborhood Hits	856	Shared Neighborhood Hits	31
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

RFFL_MOUSE
θ value	0.47712 (rank : 128)	NC score	0.058193 (rank : 210)
Query Neighborhood Hits	257	Target Neighborhood Hits	145	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RGS3_MOUSE
θ value	0.47712 (rank : 129)	NC score	0.041158 (rank : 272)
Query Neighborhood Hits	257	Target Neighborhood Hits	1621	Shared Neighborhood Hits	48
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TARA_MOUSE
θ value	0.47712 (rank : 130)	NC score	0.045140 (rank : 270)
Query Neighborhood Hits	257	Target Neighborhood Hits	1133	Shared Neighborhood Hits	56
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ZIM3_HUMAN
θ value	0.47712 (rank : 131)	NC score	0.019935 (rank : 312)
Query Neighborhood Hits	257	Target Neighborhood Hits	765	Shared Neighborhood Hits	61
SwissProt Accessions	Q96PE6	Gene names	ZIM3
Domain Architecture
Description	Zinc finger imprinted 3.

ZN317_HUMAN
θ value	0.47712 (rank : 132)	NC score	0.020358 (rank : 302)
Query Neighborhood Hits	257	Target Neighborhood Hits	759	Shared Neighborhood Hits	65
SwissProt Accessions	Q96PQ6, Q96PM0, Q96PM1, Q96PT2	Gene names	ZNF317
Domain Architecture
Description	Zinc finger protein 317.

ZN440_HUMAN
θ value	0.47712 (rank : 133)	NC score	0.021702 (rank : 292)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IYI8, Q8N1R9	Gene names	ZNF440
Domain Architecture
Description	Zinc finger protein 440.

CO1A2_MOUSE
θ value	0.62314 (rank : 134)	NC score	0.011051 (rank : 367)
Query Neighborhood Hits	257	Target Neighborhood Hits	388	Shared Neighborhood Hits	20
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CYH2_HUMAN
θ value	0.62314 (rank : 135)	NC score	0.051363 (rank : 250)
Query Neighborhood Hits	257	Target Neighborhood Hits	175	Shared Neighborhood Hits	30
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.62314 (rank : 136)	NC score	0.051364 (rank : 249)
Query Neighborhood Hits	257	Target Neighborhood Hits	171	Shared Neighborhood Hits	30
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

ZNF44_HUMAN
θ value	0.62314 (rank : 137)	NC score	0.020962 (rank : 295)
Query Neighborhood Hits	257	Target Neighborhood Hits	757	Shared Neighborhood Hits	67
SwissProt Accessions	P15621, P17018, Q9ULZ7	Gene names	ZNF44, KOX7
Domain Architecture
Description	Zinc finger protein 44 (Zinc finger protein KOX7) (Gonadotropin- inducible transcription repressor 2) (GIOT-2).

ZNF70_HUMAN
θ value	0.62314 (rank : 138)	NC score	0.020044 (rank : 308)
Query Neighborhood Hits	257	Target Neighborhood Hits	760	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

SALL3_HUMAN
θ value	0.813845 (rank : 139)	NC score	0.024694 (rank : 287)
Query Neighborhood Hits	257	Target Neighborhood Hits	1066	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

EPHAA_HUMAN
θ value	1.06291 (rank : 140)	NC score	0.000188 (rank : 393)
Query Neighborhood Hits	257	Target Neighborhood Hits	960	Shared Neighborhood Hits	12
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

GCYB2_HUMAN
θ value	1.06291 (rank : 141)	NC score	0.013799 (rank : 357)
Query Neighborhood Hits	257	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

ZN491_HUMAN
θ value	1.06291 (rank : 142)	NC score	0.020339 (rank : 303)
Query Neighborhood Hits	257	Target Neighborhood Hits	734	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N8L2, Q8NAT8	Gene names	ZNF491
Domain Architecture	No domain graphic available
Description	Zinc finger protein 491.

ZN563_HUMAN
θ value	1.06291 (rank : 143)	NC score	0.021109 (rank : 294)
Query Neighborhood Hits	257	Target Neighborhood Hits	754	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TA94, Q8NAT7	Gene names	ZNF563
Domain Architecture	No domain graphic available
Description	Zinc finger protein 563.

ZN699_HUMAN
θ value	1.06291 (rank : 144)	NC score	0.020384 (rank : 301)
Query Neighborhood Hits	257	Target Neighborhood Hits	773	Shared Neighborhood Hits	72
SwissProt Accessions	Q32M78, Q8N9A1	Gene names	ZNF699
Domain Architecture	No domain graphic available
Description	Zinc finger protein 699 (Hangover homolog).

C2TA_HUMAN
θ value	1.38821 (rank : 145)	NC score	0.012097 (rank : 361)
Query Neighborhood Hits	257	Target Neighborhood Hits	190	Shared Neighborhood Hits	10
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

DGKH_HUMAN
θ value	1.38821 (rank : 146)	NC score	0.074036 (rank : 171)
Query Neighborhood Hits	257	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

SYTL4_HUMAN
θ value	1.38821 (rank : 147)	NC score	0.047922 (rank : 269)
Query Neighborhood Hits	257	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	1.38821 (rank : 148)	NC score	0.035809 (rank : 278)
Query Neighborhood Hits	257	Target Neighborhood Hits	137	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_MOUSE
θ value	1.38821 (rank : 149)	NC score	0.028365 (rank : 284)
Query Neighborhood Hits	257	Target Neighborhood Hits	154	Shared Neighborhood Hits	16
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

ZN136_HUMAN
θ value	1.38821 (rank : 150)	NC score	0.020868 (rank : 297)
Query Neighborhood Hits	257	Target Neighborhood Hits	739	Shared Neighborhood Hits	64
SwissProt Accessions	P52737	Gene names	ZNF136
Domain Architecture
Description	Zinc finger protein 136.

ZN181_HUMAN
θ value	1.38821 (rank : 151)	NC score	0.020024 (rank : 309)
Query Neighborhood Hits	257	Target Neighborhood Hits	764	Shared Neighborhood Hits	67
SwissProt Accessions	Q2M3W8, Q49A75	Gene names	ZNF181
Domain Architecture	No domain graphic available
Description	Zinc finger protein 181 (HHZ181).

ZN433_HUMAN
θ value	1.38821 (rank : 152)	NC score	0.021195 (rank : 293)
Query Neighborhood Hits	257	Target Neighborhood Hits	782	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N7K0	Gene names	ZNF433
Domain Architecture
Description	Zinc finger protein 433.

ZN700_HUMAN
θ value	1.38821 (rank : 153)	NC score	0.020615 (rank : 299)
Query Neighborhood Hits	257	Target Neighborhood Hits	772	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H0M5	Gene names	ZNF700
Domain Architecture	No domain graphic available
Description	Zinc finger protein 700.

ZNF25_HUMAN
θ value	1.38821 (rank : 154)	NC score	0.019290 (rank : 322)
Query Neighborhood Hits	257	Target Neighborhood Hits	763	Shared Neighborhood Hits	62
SwissProt Accessions	P17030, Q8IYE3, Q8NDD6, Q96MU2	Gene names	ZNF25, KOX19
Domain Architecture
Description	Zinc finger protein 25 (Zinc finger protein KOX19).

ZNF26_HUMAN
θ value	1.38821 (rank : 155)	NC score	0.018863 (rank : 334)
Query Neighborhood Hits	257	Target Neighborhood Hits	736	Shared Neighborhood Hits	61
SwissProt Accessions	P17031, Q9NWL3	Gene names	ZNF26, KOX20
Domain Architecture	No domain graphic available
Description	Zinc finger protein 26 (Zinc finger protein KOX20).

ALS2_HUMAN
θ value	1.81305 (rank : 156)	NC score	0.104345 (rank : 129)
Query Neighborhood Hits	257	Target Neighborhood Hits	121	Shared Neighborhood Hits	23
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

GPV_HUMAN
θ value	1.81305 (rank : 157)	NC score	-0.000775 (rank : 395)
Query Neighborhood Hits	257	Target Neighborhood Hits	284	Shared Neighborhood Hits	3
SwissProt Accessions	P40197	Gene names	GP5
Domain Architecture
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

MYNN_MOUSE
θ value	1.81305 (rank : 158)	NC score	0.017926 (rank : 347)
Query Neighborhood Hits	257	Target Neighborhood Hits	820	Shared Neighborhood Hits	61
SwissProt Accessions	Q99MD8, Q6P1G7, Q8BT55, Q922I4, Q9CSA0, Q9CXJ8	Gene names	Mynn
Domain Architecture	No domain graphic available
Description	Myoneurin.

ZN197_HUMAN
θ value	1.81305 (rank : 159)	NC score	0.019110 (rank : 327)
Query Neighborhood Hits	257	Target Neighborhood Hits	788	Shared Neighborhood Hits	62
SwissProt Accessions	O14709	Gene names	ZNF197, ZNF166
Domain Architecture
Description	Zinc finger protein 197 (ZnF20).

ZN248_HUMAN
θ value	1.81305 (rank : 160)	NC score	0.019370 (rank : 319)
Query Neighborhood Hits	257	Target Neighborhood Hits	749	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NDW4, Q9UMP3	Gene names	ZNF248
Domain Architecture
Description	Zinc finger protein 248.

ZN347_HUMAN
θ value	1.81305 (rank : 161)	NC score	0.019359 (rank : 320)
Query Neighborhood Hits	257	Target Neighborhood Hits	756	Shared Neighborhood Hits	62
SwissProt Accessions	Q96SE7, Q8TCN1	Gene names	ZNF347, ZNF1111
Domain Architecture
Description	Zinc finger protein 347 (Zinc finger protein 1111).

CYH1_HUMAN
θ value	2.36792 (rank : 162)	NC score	0.055124 (rank : 223)
Query Neighborhood Hits	257	Target Neighborhood Hits	184	Shared Neighborhood Hits	34
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

MAGE1_HUMAN
θ value	2.36792 (rank : 163)	NC score	0.013359 (rank : 358)
Query Neighborhood Hits	257	Target Neighborhood Hits	1389	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

NCOR2_HUMAN
θ value	2.36792 (rank : 164)	NC score	0.016013 (rank : 354)
Query Neighborhood Hits	257	Target Neighborhood Hits	870	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

RFFL_HUMAN
θ value	2.36792 (rank : 165)	NC score	0.048043 (rank : 268)
Query Neighborhood Hits	257	Target Neighborhood Hits	175	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RN125_HUMAN
θ value	2.36792 (rank : 166)	NC score	0.006471 (rank : 379)
Query Neighborhood Hits	257	Target Neighborhood Hits	230	Shared Neighborhood Hits	8
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

SYTL5_HUMAN
θ value	2.36792 (rank : 167)	NC score	0.023045 (rank : 290)
Query Neighborhood Hits	257	Target Neighborhood Hits	237	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TAF5L_HUMAN
θ value	2.36792 (rank : 168)	NC score	0.004538 (rank : 384)
Query Neighborhood Hits	257	Target Neighborhood Hits	330	Shared Neighborhood Hits	9
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

TAF5L_MOUSE
θ value	2.36792 (rank : 169)	NC score	0.004129 (rank : 386)
Query Neighborhood Hits	257	Target Neighborhood Hits	337	Shared Neighborhood Hits	9
SwissProt Accessions	Q91WQ5, Q8BTL5	Gene names	Taf5l, Paf65b
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

ZN682_HUMAN
θ value	2.36792 (rank : 170)	NC score	0.018829 (rank : 335)
Query Neighborhood Hits	257	Target Neighborhood Hits	779	Shared Neighborhood Hits	63
SwissProt Accessions	O95780, Q96JV9	Gene names	ZNF682
Domain Architecture	No domain graphic available
Description	Zinc finger protein 682.

FMN1A_MOUSE
θ value	3.0926 (rank : 171)	NC score	0.008724 (rank : 371)
Query Neighborhood Hits	257	Target Neighborhood Hits	423	Shared Neighborhood Hits	11
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

PEX10_HUMAN
θ value	3.0926 (rank : 172)	NC score	0.006863 (rank : 377)
Query Neighborhood Hits	257	Target Neighborhood Hits	255	Shared Neighborhood Hits	7
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

WDFY2_HUMAN
θ value	3.0926 (rank : 173)	NC score	0.193425 (rank : 105)
Query Neighborhood Hits	257	Target Neighborhood Hits	332	Shared Neighborhood Hits	58
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	3.0926 (rank : 174)	NC score	0.194814 (rank : 103)
Query Neighborhood Hits	257	Target Neighborhood Hits	337	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

ZC3H6_MOUSE
θ value	3.0926 (rank : 175)	NC score	0.009481 (rank : 369)
Query Neighborhood Hits	257	Target Neighborhood Hits	239	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

ZN582_HUMAN
θ value	3.0926 (rank : 176)	NC score	0.018800 (rank : 337)
Query Neighborhood Hits	257	Target Neighborhood Hits	738	Shared Neighborhood Hits	62
SwissProt Accessions	Q96NG8, Q6PJT6	Gene names	ZNF582
Domain Architecture	No domain graphic available
Description	Zinc finger protein 582.

ZN595_HUMAN
θ value	3.0926 (rank : 177)	NC score	0.019322 (rank : 321)
Query Neighborhood Hits	257	Target Neighborhood Hits	798	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IYB9	Gene names	ZNF595
Domain Architecture	No domain graphic available
Description	Zinc finger protein 595.

ZN691_MOUSE
θ value	3.0926 (rank : 178)	NC score	0.019005 (rank : 332)
Query Neighborhood Hits	257	Target Neighborhood Hits	745	Shared Neighborhood Hits	62
SwissProt Accessions	Q3TDE8, Q3TAT2, Q8BIB1	Gene names	Znf691, Zfp691
Domain Architecture	No domain graphic available
Description	Zinc finger protein 691.

ZNF14_HUMAN
θ value	3.0926 (rank : 179)	NC score	0.020568 (rank : 300)
Query Neighborhood Hits	257	Target Neighborhood Hits	760	Shared Neighborhood Hits	70
SwissProt Accessions	P17017, Q9ULZ5	Gene names	ZNF14, GIOT4, KOX6
Domain Architecture
Description	Zinc finger protein 14 (Zinc finger protein KOX6) (Gonadotropin- inducible transcription repressor 4) (GIOT-4).

EP300_HUMAN
θ value	4.03905 (rank : 180)	NC score	0.005285 (rank : 383)
Query Neighborhood Hits	257	Target Neighborhood Hits	821	Shared Neighborhood Hits	25
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

HOOK1_HUMAN
θ value	4.03905 (rank : 181)	NC score	0.028594 (rank : 283)
Query Neighborhood Hits	257	Target Neighborhood Hits	942	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

MLL2_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.030351 (rank : 280)
Query Neighborhood Hits	257	Target Neighborhood Hits	1788	Shared Neighborhood Hits	62
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MVP_HUMAN
θ value	4.03905 (rank : 183)	NC score	0.009591 (rank : 368)
Query Neighborhood Hits	257	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q14764, Q96BG4, Q9BPW6, Q9BQT1, Q9UBD1	Gene names	MVP, LRP
Domain Architecture
Description	Major vault protein (MVP) (Lung resistance-related protein).

OGFR_MOUSE
θ value	4.03905 (rank : 184)	NC score	0.024619 (rank : 288)
Query Neighborhood Hits	257	Target Neighborhood Hits	584	Shared Neighborhood Hits	22
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PKHA4_HUMAN
θ value	4.03905 (rank : 185)	NC score	0.105195 (rank : 127)
Query Neighborhood Hits	257	Target Neighborhood Hits	283	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RASF5_HUMAN
θ value	4.03905 (rank : 186)	NC score	0.007070 (rank : 374)
Query Neighborhood Hits	257	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWW0, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99	Gene names	RASSF5, NORE1, RAPL
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

ROAA_MOUSE
θ value	4.03905 (rank : 187)	NC score	0.000423 (rank : 392)
Query Neighborhood Hits	257	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	Q99020, Q8BPE0	Gene names	Hnrpab, Cbf-a, Cgbfa
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A).

TARA_HUMAN
θ value	4.03905 (rank : 188)	NC score	0.035859 (rank : 277)
Query Neighborhood Hits	257	Target Neighborhood Hits	1626	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ZBT7B_MOUSE
θ value	4.03905 (rank : 189)	NC score	0.016674 (rank : 352)
Query Neighborhood Hits	257	Target Neighborhood Hits	792	Shared Neighborhood Hits	61
SwissProt Accessions	Q64321, Q80VV5	Gene names	Zbtb7b, Thpok, Zfp67
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 7B (Zinc finger protein 67) (Zfp-67) (Zinc finger protein Th-POK) (T-helper-inducing POZ/Krueppel-like factor) (Krueppel-related zinc finger protein cKrox) (c-Krox).

ZN184_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.018820 (rank : 336)
Query Neighborhood Hits	257	Target Neighborhood Hits	811	Shared Neighborhood Hits	64
SwissProt Accessions	Q99676, O60792, Q8TBA9	Gene names	ZNF184
Domain Architecture
Description	Zinc finger protein 184.

ZN300_HUMAN
θ value	4.03905 (rank : 191)	NC score	0.019059 (rank : 329)
Query Neighborhood Hits	257	Target Neighborhood Hits	748	Shared Neighborhood Hits	64
SwissProt Accessions	Q96RE9	Gene names	ZNF300
Domain Architecture
Description	Zinc finger protein 300.

ZN37A_HUMAN
θ value	4.03905 (rank : 192)	NC score	0.019157 (rank : 325)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	63
SwissProt Accessions	P17032, Q96B88	Gene names	ZNF37A, KOX21, ZNF37
Domain Architecture	No domain graphic available
Description	Zinc finger protein 37A (Zinc finger protein KOX21).

ZN442_HUMAN
θ value	4.03905 (rank : 193)	NC score	0.020842 (rank : 298)
Query Neighborhood Hits	257	Target Neighborhood Hits	744	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H7R0	Gene names	ZNF442
Domain Architecture
Description	Zinc finger protein 442.

ZNF12_HUMAN
θ value	4.03905 (rank : 194)	NC score	0.018941 (rank : 333)
Query Neighborhood Hits	257	Target Neighborhood Hits	779	Shared Neighborhood Hits	64
SwissProt Accessions	P17014, Q9ULZ6	Gene names	ZNF12, GIOT3, KOX3, ZNF325
Domain Architecture	No domain graphic available
Description	Zinc finger protein 12 (Zinc finger protein KOX3) (Zinc finger protein 325) (Gonadotropin-inducible transcription repressor 3) (GIOT-3).

ARP5_MOUSE
θ value	5.27518 (rank : 195)	NC score	0.005815 (rank : 382)
Query Neighborhood Hits	257	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q80US4, Q8BL26	Gene names	Actr5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5.

ATF4_MOUSE
θ value	5.27518 (rank : 196)	NC score	0.008560 (rank : 372)
Query Neighborhood Hits	257	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q06507, Q61906	Gene names	Atf4
Domain Architecture	No domain graphic available
Description	Cyclic AMP-dependent transcription factor ATF-4 (C/EBP-related ATF) (C/ATF) (TAXREB67 homolog).

CYH1_MOUSE
θ value	5.27518 (rank : 197)	NC score	0.052273 (rank : 241)
Query Neighborhood Hits	257	Target Neighborhood Hits	176	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

KPCG_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.015246 (rank : 355)
Query Neighborhood Hits	257	Target Neighborhood Hits	1123	Shared Neighborhood Hits	43
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MYNN_HUMAN
θ value	5.27518 (rank : 199)	NC score	0.017541 (rank : 349)
Query Neighborhood Hits	257	Target Neighborhood Hits	826	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NPC7, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NS01, Q9UIW8	Gene names	MYNN, OSZF, ZBTB31
Domain Architecture	No domain graphic available
Description	Myoneurin (Zinc finger and BTB domain-containing protein 31).

NHLC1_HUMAN
θ value	5.27518 (rank : 200)	NC score	0.040703 (rank : 274)
Query Neighborhood Hits	257	Target Neighborhood Hits	91	Shared Neighborhood Hits	10
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

PDE1C_HUMAN
θ value	5.27518 (rank : 201)	NC score	0.003835 (rank : 388)
Query Neighborhood Hits	257	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	5.27518 (rank : 202)	NC score	0.003675 (rank : 389)
Query Neighborhood Hits	257	Target Neighborhood Hits	161	Shared Neighborhood Hits	7
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

RHG25_MOUSE
θ value	5.27518 (rank : 203)	NC score	0.041004 (rank : 273)
Query Neighborhood Hits	257	Target Neighborhood Hits	492	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SAPS1_HUMAN
θ value	5.27518 (rank : 204)	NC score	0.011567 (rank : 363)
Query Neighborhood Hits	257	Target Neighborhood Hits	704	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SRRM2_HUMAN
θ value	5.27518 (rank : 205)	NC score	0.020125 (rank : 306)
Query Neighborhood Hits	257	Target Neighborhood Hits	1296	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STK31_HUMAN
θ value	5.27518 (rank : 206)	NC score	0.018508 (rank : 344)
Query Neighborhood Hits	257	Target Neighborhood Hits	570	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

VEZA_HUMAN
θ value	5.27518 (rank : 207)	NC score	0.025567 (rank : 286)
Query Neighborhood Hits	257	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HBM0, Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91	Gene names	VEZT
Domain Architecture	No domain graphic available
Description	Vezatin.

ZBTB1_HUMAN
θ value	5.27518 (rank : 208)	NC score	0.019147 (rank : 326)
Query Neighborhood Hits	257	Target Neighborhood Hits	805	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y2K1, Q86SW8	Gene names	ZBTB1, KIAA0997
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ZFYV1_HUMAN
θ value	5.27518 (rank : 209)	NC score	0.263524 (rank : 90)
Query Neighborhood Hits	257	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZN283_HUMAN
θ value	5.27518 (rank : 210)	NC score	0.020014 (rank : 310)
Query Neighborhood Hits	257	Target Neighborhood Hits	760	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N7M2	Gene names	ZNF283
Domain Architecture	No domain graphic available
Description	Zinc finger protein 283.

ZN426_HUMAN
θ value	5.27518 (rank : 211)	NC score	0.019577 (rank : 318)
Query Neighborhood Hits	257	Target Neighborhood Hits	747	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BUY5	Gene names	ZNF426
Domain Architecture
Description	Zinc finger protein 426.

ZN569_MOUSE
θ value	5.27518 (rank : 212)	NC score	0.019015 (rank : 330)
Query Neighborhood Hits	257	Target Neighborhood Hits	758	Shared Neighborhood Hits	60
SwissProt Accessions	Q80W31, O88237	Gene names	Znf569, Zfp74
Domain Architecture	No domain graphic available
Description	Zinc finger protein 569 (Zinc finger protein 74) (Zfp-74) (Mszf21).

ZNF41_HUMAN
θ value	5.27518 (rank : 213)	NC score	0.019010 (rank : 331)
Query Neighborhood Hits	257	Target Neighborhood Hits	769	Shared Neighborhood Hits	62
SwissProt Accessions	P51814, Q96LE8, Q9UMC4, Q9UMV5, Q9UMV6, Q9UMV7, Q9UMV8, Q9UMV9, Q9UMW0, Q9UMW1	Gene names	ZNF41
Domain Architecture
Description	Zinc finger protein 41.

ACINU_HUMAN
θ value	6.88961 (rank : 214)	NC score	0.017554 (rank : 348)
Query Neighborhood Hits	257	Target Neighborhood Hits	828	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

CNOT3_MOUSE
θ value	6.88961 (rank : 215)	NC score	0.012650 (rank : 359)
Query Neighborhood Hits	257	Target Neighborhood Hits	504	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CO002_HUMAN
θ value	6.88961 (rank : 216)	NC score	0.020311 (rank : 304)
Query Neighborhood Hits	257	Target Neighborhood Hits	387	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

CO1A1_MOUSE
θ value	6.88961 (rank : 217)	NC score	0.015063 (rank : 356)
Query Neighborhood Hits	257	Target Neighborhood Hits	457	Shared Neighborhood Hits	25
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CYH4_MOUSE
θ value	6.88961 (rank : 218)	NC score	0.058531 (rank : 209)
Query Neighborhood Hits	257	Target Neighborhood Hits	134	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

FANCA_HUMAN
θ value	6.88961 (rank : 219)	NC score	0.006959 (rank : 376)
Query Neighborhood Hits	257	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	O15360, O75266, Q6PL10, Q92497, Q96H18, Q9UEA5, Q9UEL8, Q9UEL9, Q9UPK3, Q9Y6M2	Gene names	FANCA, FAA
Domain Architecture
Description	Fanconi anemia group A protein (Protein FACA).

GEMI5_MOUSE
θ value	6.88961 (rank : 220)	NC score	0.006677 (rank : 378)
Query Neighborhood Hits	257	Target Neighborhood Hits	424	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

K0256_MOUSE
θ value	6.88961 (rank : 221)	NC score	0.006969 (rank : 375)
Query Neighborhood Hits	257	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q6A098	Gene names	Kiaa0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

KLHL1_HUMAN
θ value	6.88961 (rank : 222)	NC score	0.002153 (rank : 391)
Query Neighborhood Hits	257	Target Neighborhood Hits	195	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR64, Q5VZ64, Q9H4X4, Q9NR65, Q9P238	Gene names	KLHL1, KIAA1490
Domain Architecture
Description	Kelch-like protein 1.

LUZP1_MOUSE
θ value	6.88961 (rank : 223)	NC score	0.028797 (rank : 282)
Query Neighborhood Hits	257	Target Neighborhood Hits	940	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

MRCKB_MOUSE
θ value	6.88961 (rank : 224)	NC score	0.022331 (rank : 291)
Query Neighborhood Hits	257	Target Neighborhood Hits	2180	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

OSR2_MOUSE
θ value	6.88961 (rank : 225)	NC score	0.016881 (rank : 350)
Query Neighborhood Hits	257	Target Neighborhood Hits	724	Shared Neighborhood Hits	61
SwissProt Accessions	Q91ZD1, Q8BPV6, Q91V54	Gene names	Osr2
Domain Architecture	No domain graphic available
Description	Protein odd-skipped-related 2.

RBBP6_MOUSE
θ value	6.88961 (rank : 226)	NC score	0.004002 (rank : 387)
Query Neighborhood Hits	257	Target Neighborhood Hits	1014	Shared Neighborhood Hits	23
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

SRRM2_MOUSE
θ value	6.88961 (rank : 227)	NC score	0.026297 (rank : 285)
Query Neighborhood Hits	257	Target Neighborhood Hits	1470	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

UBQL2_HUMAN
θ value	6.88961 (rank : 228)	NC score	0.004384 (rank : 385)
Query Neighborhood Hits	257	Target Neighborhood Hits	103	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UHD9, O94798, Q9H3W6, Q9HAZ4	Gene names	UBQLN2, PLIC2
Domain Architecture
Description	Ubiquilin-2 (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC- 2) (Ubiquitin-like product Chap1/Dsk2) (DSK2 homolog) (Chap1).

ZFYV1_MOUSE
θ value	6.88961 (rank : 229)	NC score	0.259935 (rank : 91)
Query Neighborhood Hits	257	Target Neighborhood Hits	153	Shared Neighborhood Hits	62
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZN266_HUMAN
θ value	6.88961 (rank : 230)	NC score	0.019196 (rank : 324)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	64
SwissProt Accessions	Q14584, Q6IQ07, Q6U8A5, Q8IVG3, Q8WVX1, Q96SX9	Gene names	ZNF266, KIAA2007
Domain Architecture	No domain graphic available
Description	Zinc finger protein 266 (Zinc finger protein HZF1).

ZNF83_HUMAN
θ value	6.88961 (rank : 231)	NC score	0.018663 (rank : 340)
Query Neighborhood Hits	257	Target Neighborhood Hits	737	Shared Neighborhood Hits	60
SwissProt Accessions	P51522	Gene names	ZNF83
Domain Architecture	No domain graphic available
Description	Zinc finger protein 83 (Zinc finger protein HPF1).

AATK_MOUSE
θ value	8.99809 (rank : 232)	NC score	-0.000420 (rank : 394)
Query Neighborhood Hits	257	Target Neighborhood Hits	942	Shared Neighborhood Hits	24
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ACE2_HUMAN
θ value	8.99809 (rank : 233)	NC score	0.003222 (rank : 390)
Query Neighborhood Hits	257	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYF1, Q6UWP0, Q86WT0, Q9NRA7, Q9UFZ6	Gene names	ACE2
Domain Architecture	No domain graphic available
Description	Angiotensin-converting enzyme 2 precursor (EC 3.4.17.-) (ACE-related carboxypeptidase) (Angiotensin-converting enzyme homolog) (ACEH).

AR13B_HUMAN
θ value	8.99809 (rank : 234)	NC score	0.011299 (rank : 366)
Query Neighborhood Hits	257	Target Neighborhood Hits	528	Shared Neighborhood Hits	18
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

CO2A1_HUMAN
θ value	8.99809 (rank : 235)	NC score	0.012321 (rank : 360)
Query Neighborhood Hits	257	Target Neighborhood Hits	486	Shared Neighborhood Hits	25
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO2A1_MOUSE
θ value	8.99809 (rank : 236)	NC score	0.011561 (rank : 364)
Query Neighborhood Hits	257	Target Neighborhood Hits	483	Shared Neighborhood Hits	24
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CYH3_MOUSE
θ value	8.99809 (rank : 237)	NC score	0.068114 (rank : 184)
Query Neighborhood Hits	257	Target Neighborhood Hits	148	Shared Neighborhood Hits	31
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

ERC2_MOUSE
θ value	8.99809 (rank : 238)	NC score	0.029756 (rank : 281)
Query Neighborhood Hits	257	Target Neighborhood Hits	1166	Shared Neighborhood Hits	39
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

GEMI4_HUMAN
θ value	8.99809 (rank : 239)	NC score	0.008122 (rank : 373)
Query Neighborhood Hits	257	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P57678, Q9NZS7, Q9UG32, Q9Y4Q2	Gene names	GEMIN4
Domain Architecture	No domain graphic available
Description	Component of gems 4 (Gemin-4) (p97).

K1196_HUMAN
θ value	8.99809 (rank : 240)	NC score	0.020940 (rank : 296)
Query Neighborhood Hits	257	Target Neighborhood Hits	618	Shared Neighborhood Hits	61
SwissProt Accessions	Q96KM6, Q9ULM4	Gene names	KIAA1196
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1196.

MAML1_MOUSE
θ value	8.99809 (rank : 241)	NC score	0.011812 (rank : 362)
Query Neighborhood Hits	257	Target Neighborhood Hits	279	Shared Neighborhood Hits	15
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MELPH_MOUSE
θ value	8.99809 (rank : 242)	NC score	0.065015 (rank : 192)
Query Neighborhood Hits	257	Target Neighborhood Hits	112	Shared Neighborhood Hits	17
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MTMR2_MOUSE
θ value	8.99809 (rank : 243)	NC score	0.006428 (rank : 380)
Query Neighborhood Hits	257	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2D1, Q8VHA7	Gene names	Mtmr2
Domain Architecture
Description	Myotubularin-related protein 2 (EC 3.1.3.-).

NHLC1_MOUSE
θ value	8.99809 (rank : 244)	NC score	0.050619 (rank : 256)
Query Neighborhood Hits	257	Target Neighborhood Hits	103	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

SAKS1_MOUSE
θ value	8.99809 (rank : 245)	NC score	0.009430 (rank : 370)
Query Neighborhood Hits	257	Target Neighborhood Hits	208	Shared Neighborhood Hits	9
SwissProt Accessions	Q922Y1, Q3UCP8	Gene names	Saks1, D19Ertd721e
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein) (mY33K) (Protein 2B28).

TR240_HUMAN
θ value	8.99809 (rank : 246)	NC score	0.005999 (rank : 381)
Query Neighborhood Hits	257	Target Neighborhood Hits	99	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHV7, O60334	Gene names	THRAP1, ARC250, KIAA0593, TRAP240
Domain Architecture
Description	Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Thyroid hormone receptor-associated protein 1) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP 250) (Activator-recruited cofactor 250 kDa component) (ARC250).

ZBT17_HUMAN
θ value	8.99809 (rank : 247)	NC score	0.018183 (rank : 346)
Query Neighborhood Hits	257	Target Neighborhood Hits	925	Shared Neighborhood Hits	73
SwissProt Accessions	Q13105, Q15932, Q5JYB2, Q9NUC9	Gene names	ZBTB17, MIZ1, ZNF151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Myc-interacting zinc finger protein) (Miz-1 protein).

ZFP3_HUMAN
θ value	8.99809 (rank : 248)	NC score	0.018472 (rank : 345)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	62
SwissProt Accessions	Q96NJ6	Gene names	ZFP3
Domain Architecture	No domain graphic available
Description	Zinc finger protein 3 homolog (Zfp-3).

ZN11B_HUMAN
θ value	8.99809 (rank : 249)	NC score	0.019235 (rank : 323)
Query Neighborhood Hits	257	Target Neighborhood Hits	802	Shared Neighborhood Hits	70
SwissProt Accessions	Q06732, Q86XY8, Q8NDW3	Gene names	ZNF11B
Domain Architecture	No domain graphic available
Description	Zinc finger protein 11B.

ZN132_HUMAN
θ value	8.99809 (rank : 250)	NC score	0.018660 (rank : 341)
Query Neighborhood Hits	257	Target Neighborhood Hits	752	Shared Neighborhood Hits	60
SwissProt Accessions	P52740	Gene names	ZNF132
Domain Architecture	No domain graphic available
Description	Zinc finger protein 132.

ZN135_HUMAN
θ value	8.99809 (rank : 251)	NC score	0.018685 (rank : 339)
Query Neighborhood Hits	257	Target Neighborhood Hits	742	Shared Neighborhood Hits	60
SwissProt Accessions	P52742	Gene names	ZNF135
Domain Architecture	No domain graphic available
Description	Zinc finger protein 135.

ZN165_HUMAN
θ value	8.99809 (rank : 252)	NC score	0.016698 (rank : 351)
Query Neighborhood Hits	257	Target Neighborhood Hits	734	Shared Neighborhood Hits	60
SwissProt Accessions	P49910	Gene names	ZNF165, ZPF165, ZSCAN7
Domain Architecture
Description	Zinc finger protein 165 (LD65) (Zinc finger and SCAN domain-containing protein 7).

ZN226_HUMAN
θ value	8.99809 (rank : 253)	NC score	0.018539 (rank : 343)
Query Neighborhood Hits	257	Target Neighborhood Hits	770	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NYT6, Q96TE6, Q9NS44	Gene names	ZNF226
Domain Architecture
Description	Zinc finger protein 226.

ZN267_HUMAN
θ value	8.99809 (rank : 254)	NC score	0.019106 (rank : 328)
Query Neighborhood Hits	257	Target Neighborhood Hits	786	Shared Neighborhood Hits	64
SwissProt Accessions	Q14586, Q8NE41, Q9NRJ0	Gene names	ZNF267
Domain Architecture
Description	Zinc finger protein 267 (Zinc finger protein HZF2).

ZN383_HUMAN
θ value	8.99809 (rank : 255)	NC score	0.018577 (rank : 342)
Query Neighborhood Hits	257	Target Neighborhood Hits	758	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NA42, Q6X2C7	Gene names	ZNF383
Domain Architecture	No domain graphic available
Description	Zinc finger protein 383.

ZN439_HUMAN
θ value	8.99809 (rank : 256)	NC score	0.019744 (rank : 315)
Query Neighborhood Hits	257	Target Neighborhood Hits	763	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NDP4, Q8IYZ7, Q96SU1	Gene names	ZNF439
Domain Architecture
Description	Zinc finger protein 439.

ZN611_HUMAN
θ value	8.99809 (rank : 257)	NC score	0.018783 (rank : 338)
Query Neighborhood Hits	257	Target Neighborhood Hits	769	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N823, Q69YG9	Gene names	ZNF611
Domain Architecture	No domain graphic available
Description	Zinc finger protein 611.

3BP2_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.060831 (rank : 202)
Query Neighborhood Hits	257	Target Neighborhood Hits	296	Shared Neighborhood Hits	26
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.055588 (rank : 220)
Query Neighborhood Hits	257	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

41_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.051643 (rank : 247)
Query Neighborhood Hits	257	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.050230 (rank : 264)
Query Neighborhood Hits	257	Target Neighborhood Hits	184	Shared Neighborhood Hits	6
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ABI1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.071122 (rank : 178)
Query Neighborhood Hits	257	Target Neighborhood Hits	257	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.076198 (rank : 165)
Query Neighborhood Hits	257	Target Neighborhood Hits	246	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.080252 (rank : 155)
Query Neighborhood Hits	257	Target Neighborhood Hits	350	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.078795 (rank : 158)
Query Neighborhood Hits	257	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.069944 (rank : 180)
Query Neighborhood Hits	257	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.068086 (rank : 185)
Query Neighborhood Hits	257	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.072139 (rank : 174)
Query Neighborhood Hits	257	Target Neighborhood Hits	537	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.066131 (rank : 187)
Query Neighborhood Hits	257	Target Neighborhood Hits	496	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.056358 (rank : 215)
Query Neighborhood Hits	257	Target Neighborhood Hits	175	Shared Neighborhood Hits	17
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.052734 (rank : 238)
Query Neighborhood Hits	257	Target Neighborhood Hits	175	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG6_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.376828 (rank : 80)
Query Neighborhood Hits	257	Target Neighborhood Hits	394	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHGF_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.557951 (rank : 43)
Query Neighborhood Hits	257	Target Neighborhood Hits	214	Shared Neighborhood Hits	71
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ASPP1_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.054872 (rank : 226)
Query Neighborhood Hits	257	Target Neighborhood Hits	1244	Shared Neighborhood Hits	59
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.056163 (rank : 218)
Query Neighborhood Hits	257	Target Neighborhood Hits	554	Shared Neighborhood Hits	31
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.058555 (rank : 208)
Query Neighborhood Hits	257	Target Neighborhood Hits	438	Shared Neighborhood Hits	30
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.076442 (rank : 163)
Query Neighborhood Hits	257	Target Neighborhood Hits	156	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.060833 (rank : 201)
Query Neighborhood Hits	257	Target Neighborhood Hits	197	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.051797 (rank : 246)
Query Neighborhood Hits	257	Target Neighborhood Hits	259	Shared Neighborhood Hits	26
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CD2AP_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.115039 (rank : 120)
Query Neighborhood Hits	257	Target Neighborhood Hits	315	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.114216 (rank : 122)
Query Neighborhood Hits	257	Target Neighborhood Hits	336	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CNKR1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.071930 (rank : 175)
Query Neighborhood Hits	257	Target Neighborhood Hits	154	Shared Neighborhood Hits	31
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.056261 (rank : 216)
Query Neighborhood Hits	257	Target Neighborhood Hits	197	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.056482 (rank : 214)
Query Neighborhood Hits	257	Target Neighborhood Hits	197	Shared Neighborhood Hits	26
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRKL_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.079237 (rank : 157)
Query Neighborhood Hits	257	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.077251 (rank : 161)
Query Neighborhood Hits	257	Target Neighborhood Hits	307	Shared Neighborhood Hits	21
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.071406 (rank : 176)
Query Neighborhood Hits	257	Target Neighborhood Hits	308	Shared Neighborhood Hits	20
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.075077 (rank : 168)
Query Neighborhood Hits	257	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.052447 (rank : 240)
Query Neighborhood Hits	257	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CYH3_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.051218 (rank : 251)
Query Neighborhood Hits	257	Target Neighborhood Hits	137	Shared Neighborhood Hits	27
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH4_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.053406 (rank : 231)
Query Neighborhood Hits	257	Target Neighborhood Hits	135	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

DBNL_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.065120 (rank : 191)
Query Neighborhood Hits	257	Target Neighborhood Hits	244	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.062711 (rank : 198)
Query Neighborhood Hits	257	Target Neighborhood Hits	306	Shared Neighborhood Hits	22
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.050433 (rank : 260)
Query Neighborhood Hits	257	Target Neighborhood Hits	599	Shared Neighborhood Hits	36
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.051103 (rank : 252)
Query Neighborhood Hits	257	Target Neighborhood Hits	625	Shared Neighborhood Hits	39
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKD_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.054676 (rank : 228)
Query Neighborhood Hits	257	Target Neighborhood Hits	231	Shared Neighborhood Hits	23
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

E41L1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.050052 (rank : 267)
Query Neighborhood Hits	257	Target Neighborhood Hits	180	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.050070 (rank : 266)
Query Neighborhood Hits	257	Target Neighborhood Hits	459	Shared Neighborhood Hits	11
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.051941 (rank : 243)
Query Neighborhood Hits	257	Target Neighborhood Hits	113	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.050232 (rank : 263)
Query Neighborhood Hits	257	Target Neighborhood Hits	250	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.051836 (rank : 244)
Query Neighborhood Hits	257	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.053343 (rank : 233)
Query Neighborhood Hits	257	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.051820 (rank : 245)
Query Neighborhood Hits	257	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EFS_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.063519 (rank : 196)
Query Neighborhood Hits	257	Target Neighborhood Hits	389	Shared Neighborhood Hits	28
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FNBP2_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.055435 (rank : 221)
Query Neighborhood Hits	257	Target Neighborhood Hits	432	Shared Neighborhood Hits	27
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FRMD5_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.050424 (rank : 261)
Query Neighborhood Hits	257	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.050766 (rank : 255)
Query Neighborhood Hits	257	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

GRAP2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.081921 (rank : 151)
Query Neighborhood Hits	257	Target Neighborhood Hits	304	Shared Neighborhood Hits	20
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.081376 (rank : 152)
Query Neighborhood Hits	257	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.101553 (rank : 133)
Query Neighborhood Hits	257	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.099903 (rank : 135)
Query Neighborhood Hits	257	Target Neighborhood Hits	309	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.089074 (rank : 144)
Query Neighborhood Hits	257	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.089023 (rank : 145)
Query Neighborhood Hits	257	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.075847 (rank : 166)
Query Neighborhood Hits	257	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.080445 (rank : 154)
Query Neighborhood Hits	257	Target Neighborhood Hits	358	Shared Neighborhood Hits	30
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.080904 (rank : 153)
Query Neighborhood Hits	257	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.050474 (rank : 259)
Query Neighborhood Hits	257	Target Neighborhood Hits	1024	Shared Neighborhood Hits	45
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.057898 (rank : 212)
Query Neighborhood Hits	257	Target Neighborhood Hits	293	Shared Neighborhood Hits	21
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.056178 (rank : 217)
Query Neighborhood Hits	257	Target Neighborhood Hits	297	Shared Neighborhood Hits	21
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LMO7_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.052038 (rank : 242)
Query Neighborhood Hits	257	Target Neighborhood Hits	507	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MYRIP_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.055422 (rank : 222)
Query Neighborhood Hits	257	Target Neighborhood Hits	207	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NCF1_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.127072 (rank : 116)
Query Neighborhood Hits	257	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.118361 (rank : 119)
Query Neighborhood Hits	257	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.105675 (rank : 126)
Query Neighborhood Hits	257	Target Neighborhood Hits	229	Shared Neighborhood Hits	24
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.093417 (rank : 140)
Query Neighborhood Hits	257	Target Neighborhood Hits	161	Shared Neighborhood Hits	18
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.093679 (rank : 138)
Query Neighborhood Hits	257	Target Neighborhood Hits	177	Shared Neighborhood Hits	20
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.100535 (rank : 134)
Query Neighborhood Hits	257	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.096846 (rank : 136)
Query Neighborhood Hits	257	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.064173 (rank : 194)
Query Neighborhood Hits	257	Target Neighborhood Hits	457	Shared Neighborhood Hits	28
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.056650 (rank : 213)
Query Neighborhood Hits	257	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.060170 (rank : 203)
Query Neighborhood Hits	257	Target Neighborhood Hits	114	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.053331 (rank : 234)
Query Neighborhood Hits	257	Target Neighborhood Hits	288	Shared Neighborhood Hits	23
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.065407 (rank : 189)
Query Neighborhood Hits	257	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSBL9_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.061438 (rank : 199)
Query Neighborhood Hits	257	Target Neighborhood Hits	138	Shared Neighborhood Hits	26
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSTF1_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.066347 (rank : 186)
Query Neighborhood Hits	257	Target Neighborhood Hits	466	Shared Neighborhood Hits	23
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.065687 (rank : 188)
Query Neighborhood Hits	257	Target Neighborhood Hits	467	Shared Neighborhood Hits	23
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.050557 (rank : 257)
Query Neighborhood Hits	257	Target Neighborhood Hits	479	Shared Neighborhood Hits	23
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PACN1_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.051479 (rank : 248)
Query Neighborhood Hits	257	Target Neighborhood Hits	320	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.050782 (rank : 254)
Query Neighborhood Hits	257	Target Neighborhood Hits	283	Shared Neighborhood Hits	24
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.055089 (rank : 225)
Query Neighborhood Hits	257	Target Neighborhood Hits	339	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.055105 (rank : 224)
Query Neighborhood Hits	257	Target Neighborhood Hits	382	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.052910 (rank : 236)
Query Neighborhood Hits	257	Target Neighborhood Hits	385	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.054305 (rank : 230)
Query Neighborhood Hits	257	Target Neighborhood Hits	380	Shared Neighborhood Hits	25
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.053189 (rank : 235)
Query Neighborhood Hits	257	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.054603 (rank : 229)
Query Neighborhood Hits	257	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA2_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.057986 (rank : 211)
Query Neighborhood Hits	257	Target Neighborhood Hits	119	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.063727 (rank : 195)
Query Neighborhood Hits	257	Target Neighborhood Hits	116	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.103591 (rank : 130)
Query Neighborhood Hits	257	Target Neighborhood Hits	202	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.104476 (rank : 128)
Query Neighborhood Hits	257	Target Neighborhood Hits	455	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.075130 (rank : 167)
Query Neighborhood Hits	257	Target Neighborhood Hits	293	Shared Neighborhood Hits	23
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.076494 (rank : 162)
Query Neighborhood Hits	257	Target Neighborhood Hits	314	Shared Neighborhood Hits	23
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.063326 (rank : 197)
Query Neighborhood Hits	257	Target Neighborhood Hits	280	Shared Neighborhood Hits	15
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.078591 (rank : 159)
Query Neighborhood Hits	257	Target Neighborhood Hits	389	Shared Neighborhood Hits	26
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.076315 (rank : 164)
Query Neighborhood Hits	257	Target Neighborhood Hits	377	Shared Neighborhood Hits	30
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.050311 (rank : 262)
Query Neighborhood Hits	257	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RHG04_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.064915 (rank : 193)
Query Neighborhood Hits	257	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.050489 (rank : 258)
Query Neighborhood Hits	257	Target Neighborhood Hits	281	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.050973 (rank : 253)
Query Neighborhood Hits	257	Target Neighborhood Hits	1479	Shared Neighborhood Hits	62
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RNF34_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.050153 (rank : 265)
Query Neighborhood Hits	257	Target Neighborhood Hits	153	Shared Neighborhood Hits	32
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.052782 (rank : 237)
Query Neighborhood Hits	257	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RPGF1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.056153 (rank : 219)
Query Neighborhood Hits	257	Target Neighborhood Hits	262	Shared Neighborhood Hits	13
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RUFY3_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.059086 (rank : 206)
Query Neighborhood Hits	257	Target Neighborhood Hits	594	Shared Neighborhood Hits	20
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.059574 (rank : 204)
Query Neighborhood Hits	257	Target Neighborhood Hits	579	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SH3G1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.074697 (rank : 170)
Query Neighborhood Hits	257	Target Neighborhood Hits	307	Shared Neighborhood Hits	25
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.070672 (rank : 179)
Query Neighborhood Hits	257	Target Neighborhood Hits	291	Shared Neighborhood Hits	22
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.073843 (rank : 173)
Query Neighborhood Hits	257	Target Neighborhood Hits	324	Shared Neighborhood Hits	29
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.071195 (rank : 177)
Query Neighborhood Hits	257	Target Neighborhood Hits	319	Shared Neighborhood Hits	29
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.073843 (rank : 172)
Query Neighborhood Hits	257	Target Neighborhood Hits	222	Shared Neighborhood Hits	20
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.074790 (rank : 169)
Query Neighborhood Hits	257	Target Neighborhood Hits	236	Shared Neighborhood Hits	20
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.123638 (rank : 118)
Query Neighborhood Hits	257	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.114805 (rank : 121)
Query Neighborhood Hits	257	Target Neighborhood Hits	332	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.058983 (rank : 207)
Query Neighborhood Hits	257	Target Neighborhood Hits	1041	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.068190 (rank : 183)
Query Neighborhood Hits	257	Target Neighborhood Hits	446	Shared Neighborhood Hits	31
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.059254 (rank : 205)
Query Neighborhood Hits	257	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.061011 (rank : 200)
Query Neighborhood Hits	257	Target Neighborhood Hits	675	Shared Neighborhood Hits	34
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.065211 (rank : 190)
Query Neighborhood Hits	257	Target Neighborhood Hits	888	Shared Neighborhood Hits	43
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.109443 (rank : 125)
Query Neighborhood Hits	257	Target Neighborhood Hits	396	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.109490 (rank : 124)
Query Neighborhood Hits	257	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.080221 (rank : 156)
Query Neighborhood Hits	257	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.078483 (rank : 160)
Query Neighborhood Hits	257	Target Neighborhood Hits	292	Shared Neighborhood Hits	23
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.054756 (rank : 227)
Query Neighborhood Hits	257	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.052570 (rank : 239)
Query Neighborhood Hits	257	Target Neighborhood Hits	331	Shared Neighborhood Hits	27
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.053382 (rank : 232)
Query Neighborhood Hits	257	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.082256 (rank : 150)
Query Neighborhood Hits	257	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.083076 (rank : 149)
Query Neighborhood Hits	257	Target Neighborhood Hits	232	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.096320 (rank : 137)
Query Neighborhood Hits	257	Target Neighborhood Hits	276	Shared Neighborhood Hits	28
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.093459 (rank : 139)
Query Neighborhood Hits	257	Target Neighborhood Hits	268	Shared Neighborhood Hits	28
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.090656 (rank : 141)
Query Neighborhood Hits	257	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.089444 (rank : 142)
Query Neighborhood Hits	257	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.084820 (rank : 148)
Query Neighborhood Hits	257	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.085227 (rank : 147)
Query Neighborhood Hits	257	Target Neighborhood Hits	285	Shared Neighborhood Hits	25
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.069380 (rank : 182)
Query Neighborhood Hits	257	Target Neighborhood Hits	872	Shared Neighborhood Hits	51
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.069409 (rank : 181)
Query Neighborhood Hits	257	Target Neighborhood Hits	409	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.101819 (rank : 131)
Query Neighborhood Hits	257	Target Neighborhood Hits	270	Shared Neighborhood Hits	27
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.101571 (rank : 132)
Query Neighborhood Hits	257	Target Neighborhood Hits	286	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

FGD3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	257	Target Neighborhood Hits	257	Shared Neighborhood Hits	257
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD3_HUMAN
NC score	0.978640 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	257	Target Neighborhood Hits	249	Shared Neighborhood Hits	148
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_HUMAN
NC score	0.955435 (rank : 3)	θ value	7.10925e-122 (rank : 7)
Query Neighborhood Hits	257	Target Neighborhood Hits	151	Shared Neighborhood Hits	126
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
NC score	0.952578 (rank : 4)	θ value	1.02182e-136 (rank : 5)
Query Neighborhood Hits	257	Target Neighborhood Hits	219	Shared Neighborhood Hits	126
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.952316 (rank : 5)	θ value	2.27638e-136 (rank : 6)
Query Neighborhood Hits	257	Target Neighborhood Hits	227	Shared Neighborhood Hits	126
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD2_MOUSE
NC score	0.951230 (rank : 6)	θ value	5.09482e-120 (rank : 8)
Query Neighborhood Hits	257	Target Neighborhood Hits	163	Shared Neighborhood Hits	124
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_HUMAN
NC score	0.945251 (rank : 7)	θ value	1.72687e-168 (rank : 3)
Query Neighborhood Hits	257	Target Neighborhood Hits	367	Shared Neighborhood Hits	134
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.944171 (rank : 8)	θ value	3.25673e-167 (rank : 4)
Query Neighborhood Hits	257	Target Neighborhood Hits	387	Shared Neighborhood Hits	135
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD6_MOUSE
NC score	0.861954 (rank : 9)	θ value	2.84797e-54 (rank : 9)
Query Neighborhood Hits	257	Target Neighborhood Hits	282	Shared Neighborhood Hits	118
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.860615 (rank : 10)	θ value	3.48141e-52 (rank : 10)
Query Neighborhood Hits	257	Target Neighborhood Hits	237	Shared Neighborhood Hits	117
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
NC score	0.785498 (rank : 11)	θ value	3.05695e-40 (rank : 11)
Query Neighborhood Hits	257	Target Neighborhood Hits	235	Shared Neighborhood Hits	106
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
NC score	0.777622 (rank : 12)	θ value	1.08726e-37 (rank : 12)
Query Neighborhood Hits	257	Target Neighborhood Hits	170	Shared Neighborhood Hits	104
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PREX1_HUMAN
NC score	0.758253 (rank : 13)	θ value	1.37858e-24 (rank : 15)
Query Neighborhood Hits	257	Target Neighborhood Hits	177	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_MOUSE
NC score	0.748073 (rank : 14)	θ value	6.20254e-17 (rank : 21)
Query Neighborhood Hits	257	Target Neighborhood Hits	98	Shared Neighborhood Hits	73
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.733669 (rank : 15)	θ value	2.35696e-16 (rank : 24)
Query Neighborhood Hits	257	Target Neighborhood Hits	98	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PKHG1_HUMAN
NC score	0.719060 (rank : 16)	θ value	1.058e-16 (rank : 23)
Query Neighborhood Hits	257	Target Neighborhood Hits	174	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG4_MOUSE
NC score	0.688925 (rank : 17)	θ value	1.74391e-19 (rank : 20)
Query Neighborhood Hits	257	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.674015 (rank : 18)	θ value	1.33526e-19 (rank : 19)
Query Neighborhood Hits	257	Target Neighborhood Hits	242	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
NC score	0.661545 (rank : 19)	θ value	5.43371e-13 (rank : 37)
Query Neighborhood Hits	257	Target Neighborhood Hits	172	Shared Neighborhood Hits	70
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG9_HUMAN
NC score	0.653057 (rank : 20)	θ value	2.69671e-12 (rank : 39)
Query Neighborhood Hits	257	Target Neighborhood Hits	235	Shared Neighborhood Hits	71
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

NGEF_HUMAN
NC score	0.652927 (rank : 21)	θ value	1.52774e-15 (rank : 28)
Query Neighborhood Hits	257	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG9_MOUSE
NC score	0.651644 (rank : 22)	θ value	3.52202e-12 (rank : 40)
Query Neighborhood Hits	257	Target Neighborhood Hits	234	Shared Neighborhood Hits	71
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGG_HUMAN
NC score	0.641181 (rank : 23)	θ value	6.21693e-09 (rank : 59)
Query Neighborhood Hits	257	Target Neighborhood Hits	129	Shared Neighborhood Hits	69
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_MOUSE
NC score	0.640051 (rank : 24)	θ value	1.52774e-15 (rank : 29)
Query Neighborhood Hits	257	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

MCF2_HUMAN
NC score	0.636898 (rank : 25)	θ value	4.30538e-10 (rank : 55)
Query Neighborhood Hits	257	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGA_HUMAN
NC score	0.623654 (rank : 26)	θ value	4.59992e-12 (rank : 41)
Query Neighborhood Hits	257	Target Neighborhood Hits	187	Shared Neighborhood Hits	67
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.620295 (rank : 27)	θ value	4.59992e-12 (rank : 42)
Query Neighborhood Hits	257	Target Neighborhood Hits	125	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_MOUSE
NC score	0.619299 (rank : 28)	θ value	5.81887e-07 (rank : 70)
Query Neighborhood Hits	257	Target Neighborhood Hits	152	Shared Neighborhood Hits	67
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG2_MOUSE
NC score	0.608261 (rank : 29)	θ value	6.41864e-14 (rank : 35)
Query Neighborhood Hits	257	Target Neighborhood Hits	120	Shared Neighborhood Hits	66
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

MCF2L_MOUSE
NC score	0.603387 (rank : 30)	θ value	1.33837e-11 (rank : 46)
Query Neighborhood Hits	257	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

TIAM1_MOUSE
NC score	0.595371 (rank : 31)	θ value	5.26297e-08 (rank : 63)
Query Neighborhood Hits	257	Target Neighborhood Hits	205	Shared Neighborhood Hits	73
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.591600 (rank : 32)	θ value	4.0297e-08 (rank : 62)
Query Neighborhood Hits	257	Target Neighborhood Hits	225	Shared Neighborhood Hits	73
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG1_HUMAN
NC score	0.590707 (rank : 33)	θ value	2.98157e-11 (rank : 48)
Query Neighborhood Hits	257	Target Neighborhood Hits	176	Shared Neighborhood Hits	70
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG3_MOUSE
NC score	0.586616 (rank : 34)	θ value	2.79066e-09 (rank : 57)
Query Neighborhood Hits	257	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.585725 (rank : 35)	θ value	6.21693e-09 (rank : 58)
Query Neighborhood Hits	257	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

FARP2_MOUSE
NC score	0.575865 (rank : 36)	θ value	5.06226e-27 (rank : 13)
Query Neighborhood Hits	257	Target Neighborhood Hits	209	Shared Neighborhood Hits	92
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

LBC_HUMAN
NC score	0.574274 (rank : 37)	θ value	1.47974e-10 (rank : 52)
Query Neighborhood Hits	257	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG8_HUMAN
NC score	0.572266 (rank : 38)	θ value	1.09739e-05 (rank : 78)
Query Neighborhood Hits	257	Target Neighborhood Hits	85	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG1_MOUSE
NC score	0.564919 (rank : 39)	θ value	1.42992e-13 (rank : 36)
Query Neighborhood Hits	257	Target Neighborhood Hits	266	Shared Neighborhood Hits	68
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

HAPIP_HUMAN
NC score	0.561826 (rank : 40)	θ value	8.10077e-17 (rank : 22)
Query Neighborhood Hits	257	Target Neighborhood Hits	350	Shared Neighborhood Hits	81
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG2_HUMAN
NC score	0.561352 (rank : 41)	θ value	2.20605e-14 (rank : 34)
Query Neighborhood Hits	257	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGB_HUMAN
NC score	0.561079 (rank : 42)	θ value	1.133e-10 (rank : 51)
Query Neighborhood Hits	257	Target Neighborhood Hits	375	Shared Neighborhood Hits	72
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGF_HUMAN
NC score	0.557951 (rank : 43)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	257	Target Neighborhood Hits	214	Shared Neighborhood Hits	71
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FARP2_HUMAN
NC score	0.553170 (rank : 44)	θ value	3.28125e-26 (rank : 14)
Query Neighborhood Hits	257	Target Neighborhood Hits	240	Shared Neighborhood Hits	88
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGC_HUMAN
NC score	0.533705 (rank : 45)	θ value	1.06045e-08 (rank : 60)
Query Neighborhood Hits	257	Target Neighborhood Hits	351	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PKHG4_HUMAN
NC score	0.533696 (rank : 46)	θ value	8.97725e-08 (rank : 67)
Query Neighborhood Hits	257	Target Neighborhood Hits	200	Shared Neighborhood Hits	64
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PKHF2_HUMAN
NC score	0.533150 (rank : 47)	θ value	1.69304e-06 (rank : 73)
Query Neighborhood Hits	257	Target Neighborhood Hits	75	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.532722 (rank : 48)	θ value	1.69304e-06 (rank : 74)
Query Neighborhood Hits	257	Target Neighborhood Hits	77	Shared Neighborhood Hits	62
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ARHGC_MOUSE
NC score	0.532095 (rank : 49)	θ value	1.63604e-09 (rank : 56)
Query Neighborhood Hits	257	Target Neighborhood Hits	344	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GNRP_MOUSE
NC score	0.527205 (rank : 50)	θ value	2.98157e-11 (rank : 50)
Query Neighborhood Hits	257	Target Neighborhood Hits	191	Shared Neighborhood Hits	76
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FARP1_HUMAN
NC score	0.523532 (rank : 51)	θ value	8.93572e-24 (rank : 16)
Query Neighborhood Hits	257	Target Neighborhood Hits	241	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHF1_HUMAN
NC score	0.516792 (rank : 52)	θ value	0.000270298 (rank : 87)
Query Neighborhood Hits	257	Target Neighborhood Hits	76	Shared Neighborhood Hits	61
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.514413 (rank : 53)	θ value	0.000461057 (rank : 89)
Query Neighborhood Hits	257	Target Neighborhood Hits	80	Shared Neighborhood Hits	60
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ARHG8_MOUSE
NC score	0.509400 (rank : 54)	θ value	2.44474e-05 (rank : 83)
Query Neighborhood Hits	257	Target Neighborhood Hits	79	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

VAV_MOUSE
NC score	0.494931 (rank : 55)	θ value	1.74796e-11 (rank : 47)
Query Neighborhood Hits	257	Target Neighborhood Hits	430	Shared Neighborhood Hits	73
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GNRP_HUMAN
NC score	0.493849 (rank : 56)	θ value	1.02475e-11 (rank : 45)
Query Neighborhood Hits	257	Target Neighborhood Hits	239	Shared Neighborhood Hits	72
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

VAV2_MOUSE
NC score	0.492287 (rank : 57)	θ value	3.07829e-16 (rank : 25)
Query Neighborhood Hits	257	Target Neighborhood Hits	456	Shared Neighborhood Hits	79
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG7_HUMAN
NC score	0.491310 (rank : 58)	θ value	1.69304e-06 (rank : 72)
Query Neighborhood Hits	257	Target Neighborhood Hits	347	Shared Neighborhood Hits	74
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV_HUMAN
NC score	0.486205 (rank : 59)	θ value	1.9326e-10 (rank : 53)
Query Neighborhood Hits	257	Target Neighborhood Hits	452	Shared Neighborhood Hits	73
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_HUMAN
NC score	0.484962 (rank : 60)	θ value	3.40345e-15 (rank : 30)
Query Neighborhood Hits	257	Target Neighborhood Hits	453	Shared Neighborhood Hits	77
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.481809 (rank : 61)	θ value	7.58209e-15 (rank : 32)
Query Neighborhood Hits	257	Target Neighborhood Hits	404	Shared Neighborhood Hits	74
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.479471 (rank : 62)	θ value	5.8054e-15 (rank : 31)
Query Neighborhood Hits	257	Target Neighborhood Hits	398	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG7_MOUSE
NC score	0.474141 (rank : 63)	θ value	9.92553e-07 (rank : 71)
Query Neighborhood Hits	257	Target Neighborhood Hits	396	Shared Neighborhood Hits	70
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DNMBP_MOUSE
NC score	0.468944 (rank : 64)	θ value	6.87365e-08 (rank : 64)
Query Neighborhood Hits	257	Target Neighborhood Hits	435	Shared Neighborhood Hits	72
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
NC score	0.450896 (rank : 65)	θ value	3.41135e-07 (rank : 69)
Query Neighborhood Hits	257	Target Neighborhood Hits	413	Shared Neighborhood Hits	77
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RGNEF_MOUSE
NC score	0.448598 (rank : 66)	θ value	6.87365e-08 (rank : 66)
Query Neighborhood Hits	257	Target Neighborhood Hits	641	Shared Neighborhood Hits	84
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ITSN2_HUMAN
NC score	0.442072 (rank : 67)	θ value	1.29331e-14 (rank : 33)
Query Neighborhood Hits	257	Target Neighborhood Hits	1173	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ABR_HUMAN
NC score	0.435938 (rank : 68)	θ value	1.02475e-11 (rank : 44)
Query Neighborhood Hits	257	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
NC score	0.434823 (rank : 69)	θ value	2.98157e-11 (rank : 49)
Query Neighborhood Hits	257	Target Neighborhood Hits	204	Shared Neighborhood Hits	63
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ITSN2_MOUSE
NC score	0.418458 (rank : 70)	θ value	9.26847e-13 (rank : 38)
Query Neighborhood Hits	257	Target Neighborhood Hits	1371	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG6_HUMAN
NC score	0.416003 (rank : 71)	θ value	4.30538e-10 (rank : 54)
Query Neighborhood Hits	257	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ITSN1_HUMAN
NC score	0.410077 (rank : 72)	θ value	8.95645e-16 (rank : 27)
Query Neighborhood Hits	257	Target Neighborhood Hits	1757	Shared Neighborhood Hits	105
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.409573 (rank : 73)	θ value	4.02038e-16 (rank : 26)
Query Neighborhood Hits	257	Target Neighborhood Hits	1669	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ZFY28_HUMAN
NC score	0.407125 (rank : 74)	θ value	0.0113563 (rank : 100)
Query Neighborhood Hits	257	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.401254 (rank : 75)	θ value	0.00035302 (rank : 88)
Query Neighborhood Hits	257	Target Neighborhood Hits	134	Shared Neighborhood Hits	52
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_MOUSE
NC score	0.390614 (rank : 76)	θ value	9.29e-05 (rank : 86)
Query Neighborhood Hits	257	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.387641 (rank : 77)	θ value	0.0113563 (rank : 99)
Query Neighborhood Hits	257	Target Neighborhood Hits	72	Shared Neighborhood Hits	57
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_HUMAN
NC score	0.383885 (rank : 78)	θ value	1.43324e-05 (rank : 81)
Query Neighborhood Hits	257	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.378584 (rank : 79)	θ value	0.0961366 (rank : 113)
Query Neighborhood Hits	257	Target Neighborhood Hits	72	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ARHG6_MOUSE
NC score	0.376828 (rank : 80)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	257	Target Neighborhood Hits	394	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SOS2_HUMAN
NC score	0.322127 (rank : 81)	θ value	3.77169e-06 (rank : 75)
Query Neighborhood Hits	257	Target Neighborhood Hits	193	Shared Neighborhood Hits	42
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.321792 (rank : 82)	θ value	1.09739e-05 (rank : 79)
Query Neighborhood Hits	257	Target Neighborhood Hits	274	Shared Neighborhood Hits	44
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

RBNS5_HUMAN
NC score	0.319481 (rank : 83)	θ value	7.1131e-05 (rank : 84)
Query Neighborhood Hits	257	Target Neighborhood Hits	242	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.315017 (rank : 84)	θ value	7.1131e-05 (rank : 85)
Query Neighborhood Hits	257	Target Neighborhood Hits	266	Shared Neighborhood Hits	57
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

SOS1_MOUSE
NC score	0.302821 (rank : 85)	θ value	1.43324e-05 (rank : 80)
Query Neighborhood Hits	257	Target Neighborhood Hits	281	Shared Neighborhood Hits	46
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

HGS_MOUSE
NC score	0.302327 (rank : 86)	θ value	0.00228821 (rank : 91)
Query Neighborhood Hits	257	Target Neighborhood Hits	589	Shared Neighborhood Hits	67
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.300964 (rank : 87)	θ value	0.00869519 (rank : 96)
Query Neighborhood Hits	257	Target Neighborhood Hits	517	Shared Neighborhood Hits	63
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ZFY19_HUMAN
NC score	0.280874 (rank : 88)	θ value	0.0148317 (rank : 101)
Query Neighborhood Hits	257	Target Neighborhood Hits	206	Shared Neighborhood Hits	76
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
NC score	0.272685 (rank : 89)	θ value	0.0252991 (rank : 104)
Query Neighborhood Hits	257	Target Neighborhood Hits	143	Shared Neighborhood Hits	61
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFYV1_HUMAN
NC score	0.263524 (rank : 90)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	257	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.259935 (rank : 91)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	257	Target Neighborhood Hits	153	Shared Neighborhood Hits	62
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

FYV1_HUMAN
NC score	0.249719 (rank : 92)	θ value	0.0431538 (rank : 106)
Query Neighborhood Hits	257	Target Neighborhood Hits	217	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.246146 (rank : 93)	θ value	0.0431538 (rank : 107)
Query Neighborhood Hits	257	Target Neighborhood Hits	191	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

DUET_HUMAN
NC score	0.237939 (rank : 94)	θ value	1.6852e-22 (rank : 17)
Query Neighborhood Hits	257	Target Neighborhood Hits	1220	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

WDFY3_HUMAN
NC score	0.234827 (rank : 95)	θ value	6.43352e-06 (rank : 76)
Query Neighborhood Hits	257	Target Neighborhood Hits	348	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
NC score	0.234707 (rank : 96)	θ value	6.43352e-06 (rank : 77)
Query Neighborhood Hits	257	Target Neighborhood Hits	332	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

RUFY2_MOUSE
NC score	0.230669 (rank : 97)	θ value	1.87187e-05 (rank : 82)
Query Neighborhood Hits	257	Target Neighborhood Hits	820	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

TRIO_HUMAN
NC score	0.230447 (rank : 98)	θ value	4.58923e-20 (rank : 18)
Query Neighborhood Hits	257	Target Neighborhood Hits	1580	Shared Neighborhood Hits	99
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

RUFY1_MOUSE
NC score	0.224928 (rank : 99)	θ value	0.00175202 (rank : 90)
Query Neighborhood Hits	257	Target Neighborhood Hits	765	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY1_HUMAN
NC score	0.220912 (rank : 100)	θ value	0.00390308 (rank : 92)
Query Neighborhood Hits	257	Target Neighborhood Hits	848	Shared Neighborhood Hits	74
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY1_HUMAN
NC score	0.215319 (rank : 101)	θ value	0.21417 (rank : 120)
Query Neighborhood Hits	257	Target Neighborhood Hits	305	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

MTMR3_HUMAN
NC score	0.205128 (rank : 102)	θ value	0.0736092 (rank : 110)
Query Neighborhood Hits	257	Target Neighborhood Hits	163	Shared Neighborhood Hits	53
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

WDFY2_MOUSE
NC score	0.194814 (rank : 103)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	257	Target Neighborhood Hits	337	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

RUFY2_HUMAN
NC score	0.194418 (rank : 104)	θ value	3.08544e-08 (rank : 61)
Query Neighborhood Hits	257	Target Neighborhood Hits	1208	Shared Neighborhood Hits	76
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

WDFY2_HUMAN
NC score	0.193425 (rank : 105)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	257	Target Neighborhood Hits	332	Shared Neighborhood Hits	58
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

ZFY27_MOUSE
NC score	0.181917 (rank : 106)	θ value	0.0431538 (rank : 108)
Query Neighborhood Hits	257	Target Neighborhood Hits	53	Shared Neighborhood Hits	42
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.174163 (rank : 107)	θ value	0.0563607 (rank : 109)
Query Neighborhood Hits	257	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

PKHA6_HUMAN
NC score	0.167219 (rank : 108)	θ value	0.0330416 (rank : 105)
Query Neighborhood Hits	257	Target Neighborhood Hits	556	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.163891 (rank : 109)	θ value	0.0193708 (rank : 102)
Query Neighborhood Hits	257	Target Neighborhood Hits	591	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

EEA1_MOUSE
NC score	0.160589 (rank : 110)	θ value	6.87365e-08 (rank : 65)
Query Neighborhood Hits	257	Target Neighborhood Hits	1637	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

FYCO1_HUMAN
NC score	0.158472 (rank : 111)	θ value	0.0113563 (rank : 98)
Query Neighborhood Hits	257	Target Neighborhood Hits	1149	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

EEA1_HUMAN
NC score	0.149935 (rank : 112)	θ value	1.53129e-07 (rank : 68)
Query Neighborhood Hits	257	Target Neighborhood Hits	1796	Shared Neighborhood Hits	92
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

FYCO1_MOUSE
NC score	0.147885 (rank : 113)	θ value	0.00665767 (rank : 95)
Query Neighborhood Hits	257	Target Neighborhood Hits	1059	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ANFY1_MOUSE
NC score	0.144201 (rank : 114)	θ value	0.00509761 (rank : 94)
Query Neighborhood Hits	257	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.144151 (rank : 115)	θ value	0.00509761 (rank : 93)
Query Neighborhood Hits	257	Target Neighborhood Hits	480	Shared Neighborhood Hits	58
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

NCF1_HUMAN
NC score	0.127072 (rank : 116)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	257	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ALS2_MOUSE
NC score	0.126173 (rank : 117)	θ value	0.0252991 (rank : 103)
Query Neighborhood Hits	257	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SH3K1_HUMAN
NC score	0.123638 (rank : 118)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	257	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCF1_MOUSE
NC score	0.118361 (rank : 119)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	257	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CD2AP_HUMAN
NC score	0.115039 (rank : 120)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	257	Target Neighborhood Hits	315	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_MOUSE
NC score	0.114805 (rank : 121)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	257	Target Neighborhood Hits	332	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.114216 (rank : 122)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	257	Target Neighborhood Hits	336	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

OBSCN_HUMAN
NC score	0.113242 (rank : 123)	θ value	7.84624e-12 (rank : 43)
Query Neighborhood Hits	257	Target Neighborhood Hits	1931	Shared Neighborhood Hits	82
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SRBS1_MOUSE
NC score	0.109490 (rank : 124)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	257	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.109443 (rank : 125)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	257	Target Neighborhood Hits	396	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF2_HUMAN
NC score	0.105675 (rank : 126)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	257	Target Neighborhood Hits	229	Shared Neighborhood Hits	24
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PKHA4_HUMAN
NC score	0.105195 (rank : 127)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	257	Target Neighborhood Hits	283	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
NC score	0.104476 (rank : 128)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	257	Target Neighborhood Hits	455	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

ALS2_HUMAN
NC score	0.104345 (rank : 129)	θ value	1.81305 (rank : 156)
Query Neighborhood Hits	257	Target Neighborhood Hits	121	Shared Neighborhood Hits	23
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

PKHA4_MOUSE
NC score	0.103591 (rank : 130)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	257	Target Neighborhood Hits	202	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

VINEX_HUMAN
NC score	0.101819 (rank : 131)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	257	Target Neighborhood Hits	270	Shared Neighborhood Hits	27
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.101571 (rank : 132)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	257	Target Neighborhood Hits	286	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GRAP_HUMAN
NC score	0.101553 (rank : 133)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	257	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK1_HUMAN
NC score	0.100535 (rank : 134)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	257	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP_MOUSE
NC score	0.099903 (rank : 135)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	257	Target Neighborhood Hits	309	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.096846 (rank : 136)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	257	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

STAC_HUMAN
NC score	0.096320 (rank : 137)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	257	Target Neighborhood Hits	276	Shared Neighborhood Hits	28
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF4_MOUSE
NC score	0.093679 (rank : 138)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	257	Target Neighborhood Hits	177	Shared Neighborhood Hits	20
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_MOUSE
NC score	0.093459 (rank : 139)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	257	Target Neighborhood Hits	268	Shared Neighborhood Hits	28
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF4_HUMAN
NC score	0.093417 (rank : 140)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	257	Target Neighborhood Hits	161	Shared Neighborhood Hits	18
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM1_HUMAN
NC score	0.090656 (rank : 141)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	257	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.089444 (rank : 142)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	257	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SWP70_HUMAN
NC score	0.089155 (rank : 143)	θ value	0.21417 (rank : 119)
Query Neighborhood Hits	257	Target Neighborhood Hits	973	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GRB2_HUMAN
NC score	0.089074 (rank : 144)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	257	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.089023 (rank : 145)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	257	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SWP70_MOUSE
NC score	0.087095 (rank : 146)	θ value	0.0961366 (rank : 112)
Query Neighborhood Hits	257	Target Neighborhood Hits	1097	Shared Neighborhood Hits	60
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

STAM2_MOUSE
NC score	0.085227 (rank : 147)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	257	Target Neighborhood Hits	285	Shared Neighborhood Hits	25
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.084820 (rank : 148)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	257	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAC3_MOUSE
NC score	0.083076 (rank : 149)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	257	Target Neighborhood Hits	232	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.082256 (rank : 150)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	257	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRAP2_HUMAN
NC score	0.081921 (rank : 151)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	257	Target Neighborhood Hits	304	Shared Neighborhood Hits	20
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.081376 (rank : 152)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	257	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

HCLS1_MOUSE
NC score	0.080904 (rank : 153)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	257	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.080445 (rank : 154)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	257	Target Neighborhood Hits	358	Shared Neighborhood Hits	30
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI2_HUMAN
NC score	0.080252 (rank : 155)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	257	Target Neighborhood Hits	350	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SRC8_HUMAN
NC score	0.080221 (rank : 156)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	257	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

CRKL_HUMAN
NC score	0.079237 (rank : 157)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	257	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ABI2_MOUSE
NC score	0.078795 (rank : 158)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	257	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PPIP1_HUMAN
NC score	0.078591 (rank : 159)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	257	Target Neighborhood Hits	389	Shared Neighborhood Hits	26
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SRC8_MOUSE
NC score	0.078483 (rank : 160)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	257	Target Neighborhood Hits	292	Shared Neighborhood Hits	23
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

CRKL_MOUSE
NC score	0.077251 (rank : 161)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	257	Target Neighborhood Hits	307	Shared Neighborhood Hits	21
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PLCG1_MOUSE
NC score	0.076494 (rank : 162)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	257	Target Neighborhood Hits	314	Shared Neighborhood Hits	23
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

BI2L1_HUMAN
NC score	0.076442 (rank : 163)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	257	Target Neighborhood Hits	156	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PPIP1_MOUSE
NC score	0.076315 (rank : 164)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	257	Target Neighborhood Hits	377	Shared Neighborhood Hits	30
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ABI1_MOUSE
NC score	0.076198 (rank : 165)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	257	Target Neighborhood Hits	246	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

GRP3_HUMAN
NC score	0.075847 (rank : 166)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	257	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

PLCG1_HUMAN
NC score	0.075130 (rank : 167)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	257	Target Neighborhood Hits	293	Shared Neighborhood Hits	23
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CRK_MOUSE
NC score	0.075077 (rank : 168)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	257	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G3_MOUSE
NC score	0.074790 (rank : 169)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	257	Target Neighborhood Hits	236	Shared Neighborhood Hits	20
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G1_HUMAN
NC score	0.074697 (rank : 170)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	257	Target Neighborhood Hits	307	Shared Neighborhood Hits	25
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

DGKH_HUMAN
NC score	0.074036 (rank : 171)	θ value	1.38821 (rank : 146)
Query Neighborhood Hits	257	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

SH3G3_HUMAN
NC score	0.073843 (rank : 172)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	257	Target Neighborhood Hits	222	Shared Neighborhood Hits	20
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G2_HUMAN
NC score	0.073843 (rank : 173)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	257	Target Neighborhood Hits	324	Shared Neighborhood Hits	29
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

AHI1_HUMAN
NC score	0.072139 (rank : 174)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	257	Target Neighborhood Hits	537	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CNKR1_HUMAN
NC score	0.071930 (rank : 175)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	257	Target Neighborhood Hits	154	Shared Neighborhood Hits	31
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CRK_HUMAN
NC score	0.071406 (rank : 176)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	257	Target Neighborhood Hits	308	Shared Neighborhood Hits	20
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G2_MOUSE
NC score	0.071195 (rank : 177)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	257	Target Neighborhood Hits	319	Shared Neighborhood Hits	29
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ABI1_HUMAN
NC score	0.071122 (rank : 178)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	257	Target Neighborhood Hits	257	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G1_MOUSE
NC score	0.070672 (rank : 179)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	257	Target Neighborhood Hits	291	Shared Neighborhood Hits	22
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ABI3_HUMAN
NC score	0.069944 (rank : 180)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	257	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

TCGAP_MOUSE
NC score	0.069409 (rank : 181)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	257	Target Neighborhood Hits	409	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_HUMAN
NC score	0.069380 (rank : 182)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	257	Target Neighborhood Hits	872	Shared Neighborhood Hits	51
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SHAN2_MOUSE
NC score	0.068190 (rank : 183)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	257	Target Neighborhood Hits	446	Shared Neighborhood Hits	31
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

CYH3_MOUSE
NC score	0.068114 (rank : 184)	θ value	8.99809 (rank : 237)
Query Neighborhood Hits	257	Target Neighborhood Hits	148	Shared Neighborhood Hits	31
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

ABI3_MOUSE
NC score	0.068086 (rank : 185)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	257	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

OSTF1_HUMAN
NC score	0.066347 (rank : 186)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	257	Target Neighborhood Hits	466	Shared Neighborhood Hits	23
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

AHI1_MOUSE
NC score	0.066131 (rank : 187)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	257	Target Neighborhood Hits	496	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

OSTF1_MOUSE
NC score	0.065687 (rank : 188)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	257	Target Neighborhood Hits	467	Shared Neighborhood Hits	23
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

NPHP1_MOUSE
NC score	0.065407 (rank : 189)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	257	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SPTA2_HUMAN
NC score	0.065211 (rank : 190)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	257	Target Neighborhood Hits	888	Shared Neighborhood Hits	43
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DBNL_HUMAN
NC score	0.065120 (rank : 191)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	257	Target Neighborhood Hits	244	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

MELPH_MOUSE
NC score	0.065015 (rank : 192)	θ value	8.99809 (rank : 242)
Query Neighborhood Hits	257	Target Neighborhood Hits	112	Shared Neighborhood Hits	17
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

RHG04_HUMAN
NC score	0.064915 (rank : 193)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	257	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NEBL_HUMAN
NC score	0.064173 (rank : 194)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	257	Target Neighborhood Hits	457	Shared Neighborhood Hits	28
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PKHA2_MOUSE
NC score	0.063727 (rank : 195)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	257	Target Neighborhood Hits	116	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

EFS_MOUSE
NC score	0.063519 (rank : 196)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	257	Target Neighborhood Hits	389	Shared Neighborhood Hits	28
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PLCG2_HUMAN
NC score	0.063326 (rank : 197)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	257	Target Neighborhood Hits	280	Shared Neighborhood Hits	15
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

DBNL_MOUSE
NC score	0.062711 (rank : 198)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	257	Target Neighborhood Hits	306	Shared Neighborhood Hits	22
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

OSBL9_HUMAN
NC score	0.061438 (rank : 199)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	257	Target Neighborhood Hits	138	Shared Neighborhood Hits	26
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

SPTA1_MOUSE
NC score	0.061011 (rank : 200)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	257	Target Neighborhood Hits	675	Shared Neighborhood Hits	34
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

BI2L1_MOUSE
NC score	0.060833 (rank : 201)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	257	Target Neighborhood Hits	197	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

3BP2_HUMAN
NC score	0.060831 (rank : 202)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	257	Target Neighborhood Hits	296	Shared Neighborhood Hits	26
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

NOXO1_MOUSE
NC score	0.060170 (rank : 203)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	257	Target Neighborhood Hits	114	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

RUFY3_MOUSE
NC score	0.059574 (rank : 204)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	257	Target Neighborhood Hits	579	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SPTA1_HUMAN
NC score	0.059254 (rank : 205)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	257	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RUFY3_HUMAN
NC score	0.059086 (rank : 206)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	257	Target Neighborhood Hits	594	Shared Neighborhood Hits	20
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SHAN1_HUMAN
NC score	0.058983 (rank : 207)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	257	Target Neighborhood Hits	1041	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

BCAR1_MOUSE
NC score	0.058555 (rank : 208)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	257	Target Neighborhood Hits	438	Shared Neighborhood Hits	30
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CYH4_MOUSE
NC score	0.058531 (rank : 209)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	257	Target Neighborhood Hits	134	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

RFFL_MOUSE
NC score	0.058193 (rank : 210)	θ value	0.47712 (rank : 128)
Query Neighborhood Hits	257	Target Neighborhood Hits	145	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

PKHA2_HUMAN
NC score	0.057986 (rank : 211)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	257	Target Neighborhood Hits	119	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

LASP1_HUMAN
NC score	0.057898 (rank : 212)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	257	Target Neighborhood Hits	293	Shared Neighborhood Hits	21
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NOXO1_HUMAN
NC score	0.056650 (rank : 213)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	257	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

CNKR2_MOUSE
NC score	0.056482 (rank : 214)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	257	Target Neighborhood Hits	197	Shared Neighborhood Hits	26
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ANM2_HUMAN
NC score	0.056358 (rank : 215)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	257	Target Neighborhood Hits	175	Shared Neighborhood Hits	17
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CNKR2_HUMAN
NC score	0.056261 (rank : 216)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	257	Target Neighborhood Hits	197	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

LASP1_MOUSE
NC score	0.056178 (rank : 217)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	257	Target Neighborhood Hits	297	Shared Neighborhood Hits	21
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

BCAR1_HUMAN
NC score	0.056163 (rank : 218)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	257	Target Neighborhood Hits	554	Shared Neighborhood Hits	31
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

RPGF1_HUMAN
NC score	0.056153 (rank : 219)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	257	Target Neighborhood Hits	262	Shared Neighborhood Hits	13
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

3BP2_MOUSE
NC score	0.055588 (rank : 220)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	257	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

FNBP2_HUMAN
NC score	0.055435 (rank : 221)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	257	Target Neighborhood Hits	432	Shared Neighborhood Hits	27
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

MYRIP_MOUSE
NC score	0.055422 (rank : 222)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	257	Target Neighborhood Hits	207	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

CYH1_HUMAN
NC score	0.055124 (rank : 223)	θ value	2.36792 (rank : 162)
Query Neighborhood Hits	257	Target Neighborhood Hits	184	Shared Neighborhood Hits	34
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PACN2_MOUSE
NC score	0.055105 (rank : 224)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	257	Target Neighborhood Hits	382	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.055089 (rank : 225)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	257	Target Neighborhood Hits	339	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ASPP1_MOUSE
NC score	0.054872 (rank : 226)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	257	Target Neighborhood Hits	1244	Shared Neighborhood Hits	59
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SRGP1_HUMAN
NC score	0.054756 (rank : 227)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	257	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

DGKD_HUMAN
NC score	0.054676 (rank : 228)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	257	Target Neighborhood Hits	231	Shared Neighborhood Hits	23
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

PEX13_MOUSE
NC score	0.054603 (rank : 229)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	257	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PACN3_MOUSE
NC score	0.054305 (rank : 230)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	257	Target Neighborhood Hits	380	Shared Neighborhood Hits	25
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

CYH4_HUMAN
NC score	0.053406 (rank : 231)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	257	Target Neighborhood Hits	135	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

SRGP2_MOUSE
NC score	0.053382 (rank : 232)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	257	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

E41LB_HUMAN
NC score	0.053343 (rank : 233)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	257	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

NPHP1_HUMAN
NC score	0.053331 (rank : 234)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	257	Target Neighborhood Hits	288	Shared Neighborhood Hits	23
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PEX13_HUMAN
NC score	0.053189 (rank : 235)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	257	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PACN3_HUMAN
NC score	0.052910 (rank : 236)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	257	Target Neighborhood Hits	385	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

RNF34_MOUSE
NC score	0.052782 (rank : 237)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	257	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

ANM2_MOUSE
NC score	0.052734 (rank : 238)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	257	Target Neighborhood Hits	175	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SRGP2_HUMAN
NC score	0.052570 (rank : 239)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	257	Target Neighborhood Hits	331	Shared Neighborhood Hits	27
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

CT032_HUMAN
NC score	0.052447 (rank : 240)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	257	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CYH1_MOUSE
NC score	0.052273 (rank : 241)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	257	Target Neighborhood Hits	176	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

LMO7_HUMAN
NC score	0.052038 (rank : 242)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	257	Target Neighborhood Hits	507	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

E41L3_HUMAN
NC score	0.051941 (rank : 243)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	257	Target Neighborhood Hits	113	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L5_HUMAN
NC score	0.051836 (rank : 244)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	257	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.051820 (rank : 245)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	257	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

CASL_HUMAN
NC score	0.051797 (rank : 246)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	257	Target Neighborhood Hits	259	Shared Neighborhood Hits	26
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

41_HUMAN
NC score	0.051643 (rank : 247)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	257	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

PACN1_HUMAN
NC score	0.051479 (rank : 248)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	257	Target Neighborhood Hits	320	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

CYH2_MOUSE
NC score	0.051364 (rank : 249)	θ value	0.62314 (rank : 136)
Query Neighborhood Hits	257	Target Neighborhood Hits	171	Shared Neighborhood Hits	30
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.051363 (rank : 250)	θ value	0.62314 (rank : 135)
Query Neighborhood Hits	257	Target Neighborhood Hits	175	Shared Neighborhood Hits	30
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH3_HUMAN
NC score	0.051218 (rank : 251)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	257	Target Neighborhood Hits	137	Shared Neighborhood Hits	27
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DDEF2_MOUSE
NC score	0.051103 (rank : 252)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	257	Target Neighborhood Hits	625	Shared Neighborhood Hits	39
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

RIMB1_HUMAN
NC score	0.050973 (rank : 253)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	257	Target Neighborhood Hits	1479	Shared Neighborhood Hits	62
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

PACN1_MOUSE
NC score	0.050782 (rank : 254)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	257	Target Neighborhood Hits	283	Shared Neighborhood Hits	24
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

FRMD5_MOUSE
NC score	0.050766 (rank : 255)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	257	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

NHLC1_MOUSE
NC score	0.050619 (rank : 256)	θ value	8.99809 (rank : 244)
Query Neighborhood Hits	257	Target Neighborhood Hits	103	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

P85A_HUMAN
NC score	0.050557 (rank : 257)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	257	Target Neighborhood Hits	479	Shared Neighborhood Hits	23
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RHG26_HUMAN
NC score	0.050489 (rank : 258)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	257	Target Neighborhood Hits	281	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

IASPP_MOUSE
NC score	0.050474 (rank : 259)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	257	Target Neighborhood Hits	1024	Shared Neighborhood Hits	45
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DDEF2_HUMAN
NC score	0.050433 (rank : 260)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	257	Target Neighborhood Hits	599	Shared Neighborhood Hits	36
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

FRMD5_HUMAN
NC score	0.050424 (rank : 261)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	257	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

REPS1_MOUSE
NC score	0.050311 (rank : 262)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	257	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

E41L3_MOUSE
NC score	0.050232 (rank : 263)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	257	Target Neighborhood Hits	250	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

41_MOUSE
NC score	0.050230 (rank : 264)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	257	Target Neighborhood Hits	184	Shared Neighborhood Hits	6
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

RNF34_HUMAN
NC score	0.050153 (rank : 265)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	257	Target Neighborhood Hits	153	Shared Neighborhood Hits	32
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

E41L2_MOUSE
NC score	0.050070 (rank : 266)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	257	Target Neighborhood Hits	459	Shared Neighborhood Hits	11
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L1_HUMAN
NC score	0.050052 (rank : 267)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	257	Target Neighborhood Hits	180	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

RFFL_HUMAN
NC score	0.048043 (rank : 268)	θ value	2.36792 (rank : 165)
Query Neighborhood Hits	257	Target Neighborhood Hits	175	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

SYTL4_HUMAN
NC score	0.047922 (rank : 269)	θ value	1.38821 (rank : 147)
Query Neighborhood Hits	257	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

TARA_MOUSE
NC score	0.045140 (rank : 270)	θ value	0.47712 (rank : 130)
Query Neighborhood Hits	257	Target Neighborhood Hits	1133	Shared Neighborhood Hits	56
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CENB5_HUMAN
NC score	0.045138 (rank : 271)	θ value	0.0113563 (rank : 97)
Query Neighborhood Hits	257	Target Neighborhood Hits	395	Shared Neighborhood Hits	27
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

RGS3_MOUSE
NC score	0.041158 (rank : 272)	θ value	0.47712 (rank : 129)
Query Neighborhood Hits	257	Target Neighborhood Hits	1621	Shared Neighborhood Hits	48
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RHG25_MOUSE
NC score	0.041004 (rank : 273)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	257	Target Neighborhood Hits	492	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

NHLC1_HUMAN
NC score	0.040703 (rank : 274)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	257	Target Neighborhood Hits	91	Shared Neighborhood Hits	10
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

OGFR_HUMAN
NC score	0.038384 (rank : 275)	θ value	0.163984 (rank : 116)
Query Neighborhood Hits	257	Target Neighborhood Hits	1582	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RNF37_MOUSE
NC score	0.036411 (rank : 276)	θ value	0.21417 (rank : 118)
Query Neighborhood Hits	257	Target Neighborhood Hits	102	Shared Neighborhood Hits	6
SwissProt Accessions	Q925F4	Gene names	Ubox5, Rnf37, Ubce7ip5, Uip5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (UbcM4-interacting protein 5) (U-box domain-containing protein 5).

TARA_HUMAN
NC score	0.035859 (rank : 277)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	257	Target Neighborhood Hits	1626	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SYTL4_MOUSE
NC score	0.035809 (rank : 278)	θ value	1.38821 (rank : 148)
Query Neighborhood Hits	257	Target Neighborhood Hits	137	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

GOGA2_HUMAN
NC score	0.033748 (rank : 279)	θ value	0.47712 (rank : 127)
Query Neighborhood Hits	257	Target Neighborhood Hits	856	Shared Neighborhood Hits	31
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

MLL2_HUMAN
NC score	0.030351 (rank : 280)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	257	Target Neighborhood Hits	1788	Shared Neighborhood Hits	62
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ERC2_MOUSE
NC score	0.029756 (rank : 281)	θ value	8.99809 (rank : 238)
Query Neighborhood Hits	257	Target Neighborhood Hits	1166	Shared Neighborhood Hits	39
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

LUZP1_MOUSE
NC score	0.028797 (rank : 282)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	257	Target Neighborhood Hits	940	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

HOOK1_HUMAN
NC score	0.028594 (rank : 283)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	257	Target Neighborhood Hits	942	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

SYTL5_MOUSE
NC score	0.028365 (rank : 284)	θ value	1.38821 (rank : 149)
Query Neighborhood Hits	257	Target Neighborhood Hits	154	Shared Neighborhood Hits	16
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SRRM2_MOUSE
NC score	0.026297 (rank : 285)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	257	Target Neighborhood Hits	1470	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

VEZA_HUMAN
NC score	0.025567 (rank : 286)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	257	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HBM0, Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91	Gene names	VEZT
Domain Architecture	No domain graphic available
Description	Vezatin.

SALL3_HUMAN
NC score	0.024694 (rank : 287)	θ value	0.813845 (rank : 139)
Query Neighborhood Hits	257	Target Neighborhood Hits	1066	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

OGFR_MOUSE
NC score	0.024619 (rank : 288)	θ value	4.03905 (rank : 184)
Query Neighborhood Hits	257	Target Neighborhood Hits	584	Shared Neighborhood Hits	22
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

ZBT40_HUMAN
NC score	0.024037 (rank : 289)	θ value	0.0736092 (rank : 111)
Query Neighborhood Hits	257	Target Neighborhood Hits	949	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

SYTL5_HUMAN
NC score	0.023045 (rank : 290)	θ value	2.36792 (rank : 167)
Query Neighborhood Hits	257	Target Neighborhood Hits	237	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

MRCKB_MOUSE
NC score	0.022331 (rank : 291)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	257	Target Neighborhood Hits	2180	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

ZN440_HUMAN
NC score	0.021702 (rank : 292)	θ value	0.47712 (rank : 133)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IYI8, Q8N1R9	Gene names	ZNF440
Domain Architecture
Description	Zinc finger protein 440.

ZN433_HUMAN
NC score	0.021195 (rank : 293)	θ value	1.38821 (rank : 152)
Query Neighborhood Hits	257	Target Neighborhood Hits	782	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N7K0	Gene names	ZNF433
Domain Architecture
Description	Zinc finger protein 433.

ZN563_HUMAN
NC score	0.021109 (rank : 294)	θ value	1.06291 (rank : 143)
Query Neighborhood Hits	257	Target Neighborhood Hits	754	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TA94, Q8NAT7	Gene names	ZNF563
Domain Architecture	No domain graphic available
Description	Zinc finger protein 563.

ZNF44_HUMAN
NC score	0.020962 (rank : 295)	θ value	0.62314 (rank : 137)
Query Neighborhood Hits	257	Target Neighborhood Hits	757	Shared Neighborhood Hits	67
SwissProt Accessions	P15621, P17018, Q9ULZ7	Gene names	ZNF44, KOX7
Domain Architecture
Description	Zinc finger protein 44 (Zinc finger protein KOX7) (Gonadotropin- inducible transcription repressor 2) (GIOT-2).

K1196_HUMAN
NC score	0.020940 (rank : 296)	θ value	8.99809 (rank : 240)
Query Neighborhood Hits	257	Target Neighborhood Hits	618	Shared Neighborhood Hits	61
SwissProt Accessions	Q96KM6, Q9ULM4	Gene names	KIAA1196
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1196.

ZN136_HUMAN
NC score	0.020868 (rank : 297)	θ value	1.38821 (rank : 150)
Query Neighborhood Hits	257	Target Neighborhood Hits	739	Shared Neighborhood Hits	64
SwissProt Accessions	P52737	Gene names	ZNF136
Domain Architecture
Description	Zinc finger protein 136.

ZN442_HUMAN
NC score	0.020842 (rank : 298)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	257	Target Neighborhood Hits	744	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H7R0	Gene names	ZNF442
Domain Architecture
Description	Zinc finger protein 442.

ZN700_HUMAN
NC score	0.020615 (rank : 299)	θ value	1.38821 (rank : 153)
Query Neighborhood Hits	257	Target Neighborhood Hits	772	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H0M5	Gene names	ZNF700
Domain Architecture	No domain graphic available
Description	Zinc finger protein 700.

ZNF14_HUMAN
NC score	0.020568 (rank : 300)	θ value	3.0926 (rank : 179)
Query Neighborhood Hits	257	Target Neighborhood Hits	760	Shared Neighborhood Hits	70
SwissProt Accessions	P17017, Q9ULZ5	Gene names	ZNF14, GIOT4, KOX6
Domain Architecture
Description	Zinc finger protein 14 (Zinc finger protein KOX6) (Gonadotropin- inducible transcription repressor 4) (GIOT-4).

ZN699_HUMAN
NC score	0.020384 (rank : 301)	θ value	1.06291 (rank : 144)
Query Neighborhood Hits	257	Target Neighborhood Hits	773	Shared Neighborhood Hits	72
SwissProt Accessions	Q32M78, Q8N9A1	Gene names	ZNF699
Domain Architecture	No domain graphic available
Description	Zinc finger protein 699 (Hangover homolog).

ZN317_HUMAN
NC score	0.020358 (rank : 302)	θ value	0.47712 (rank : 132)
Query Neighborhood Hits	257	Target Neighborhood Hits	759	Shared Neighborhood Hits	65
SwissProt Accessions	Q96PQ6, Q96PM0, Q96PM1, Q96PT2	Gene names	ZNF317
Domain Architecture
Description	Zinc finger protein 317.

ZN491_HUMAN
NC score	0.020339 (rank : 303)	θ value	1.06291 (rank : 142)
Query Neighborhood Hits	257	Target Neighborhood Hits	734	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N8L2, Q8NAT8	Gene names	ZNF491
Domain Architecture	No domain graphic available
Description	Zinc finger protein 491.

CO002_HUMAN
NC score	0.020311 (rank : 304)	θ value	6.88961 (rank : 216)
Query Neighborhood Hits	257	Target Neighborhood Hits	387	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

ZN260_MOUSE
NC score	0.020131 (rank : 305)	θ value	0.125558 (rank : 114)
Query Neighborhood Hits	257	Target Neighborhood Hits	765	Shared Neighborhood Hits	64
SwissProt Accessions	Q62513, Q3U170, Q8C2Q6, Q9R2B4	Gene names	Znf260, Zfp260
Domain Architecture	No domain graphic available
Description	Zinc finger protein 260 (Zfp-260).

SRRM2_HUMAN
NC score	0.020125 (rank : 306)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	257	Target Neighborhood Hits	1296	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ZN260_HUMAN
NC score	0.020119 (rank : 307)	θ value	0.163984 (rank : 117)
Query Neighborhood Hits	257	Target Neighborhood Hits	757	Shared Neighborhood Hits	64
SwissProt Accessions	Q3ZCT1	Gene names	ZNF260, ZFP260
Domain Architecture	No domain graphic available
Description	Zinc finger protein 260 (Zfp-260).

ZNF70_HUMAN
NC score	0.020044 (rank : 308)	θ value	0.62314 (rank : 138)
Query Neighborhood Hits	257	Target Neighborhood Hits	760	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

ZN181_HUMAN
NC score	0.020024 (rank : 309)	θ value	1.38821 (rank : 151)
Query Neighborhood Hits	257	Target Neighborhood Hits	764	Shared Neighborhood Hits	67
SwissProt Accessions	Q2M3W8, Q49A75	Gene names	ZNF181
Domain Architecture	No domain graphic available
Description	Zinc finger protein 181 (HHZ181).

ZN283_HUMAN
NC score	0.020014 (rank : 310)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	257	Target Neighborhood Hits	760	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N7M2	Gene names	ZNF283
Domain Architecture	No domain graphic available
Description	Zinc finger protein 283.

ZN418_HUMAN
NC score	0.019995 (rank : 311)	θ value	0.125558 (rank : 115)
Query Neighborhood Hits	257	Target Neighborhood Hits	776	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TF45, Q670L5, Q96N18	Gene names	ZNF418, KIAA1956
Domain Architecture
Description	Zinc finger protein 418.

ZIM3_HUMAN
NC score	0.019935 (rank : 312)	θ value	0.47712 (rank : 131)
Query Neighborhood Hits	257	Target Neighborhood Hits	765	Shared Neighborhood Hits	61
SwissProt Accessions	Q96PE6	Gene names	ZIM3
Domain Architecture
Description	Zinc finger imprinted 3.

ZN302_HUMAN
NC score	0.019835 (rank : 313)	θ value	0.365318 (rank : 124)
Query Neighborhood Hits	257	Target Neighborhood Hits	755	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR11, Q9BZD8, Q9P0J4	Gene names	ZNF302, ZNF135L, ZNF140L
Domain Architecture
Description	Zinc finger protein 302 (ZNF135-like) (ZNF140-like).

ZN502_HUMAN
NC score	0.019765 (rank : 314)	θ value	0.21417 (rank : 121)
Query Neighborhood Hits	257	Target Neighborhood Hits	762	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TBZ5	Gene names	ZNF502
Domain Architecture	No domain graphic available
Description	Zinc finger protein 502.

ZN439_HUMAN
NC score	0.019744 (rank : 315)	θ value	8.99809 (rank : 256)
Query Neighborhood Hits	257	Target Neighborhood Hits	763	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NDP4, Q8IYZ7, Q96SU1	Gene names	ZNF439
Domain Architecture
Description	Zinc finger protein 439.

ZN333_HUMAN
NC score	0.019637 (rank : 316)	θ value	0.279714 (rank : 122)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	62
SwissProt Accessions	Q96JL9, Q8TDL0	Gene names	ZNF333, KIAA1806
Domain Architecture
Description	Zinc finger protein 333.

ZN678_HUMAN
NC score	0.019578 (rank : 317)	θ value	0.365318 (rank : 125)
Query Neighborhood Hits	257	Target Neighborhood Hits	761	Shared Neighborhood Hits	66
SwissProt Accessions	Q5SXM1, Q8IVQ9	Gene names	ZNF678
Domain Architecture	No domain graphic available
Description	Zinc finger protein 678.

ZN426_HUMAN
NC score	0.019577 (rank : 318)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	257	Target Neighborhood Hits	747	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BUY5	Gene names	ZNF426
Domain Architecture
Description	Zinc finger protein 426.

ZN248_HUMAN
NC score	0.019370 (rank : 319)	θ value	1.81305 (rank : 160)
Query Neighborhood Hits	257	Target Neighborhood Hits	749	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NDW4, Q9UMP3	Gene names	ZNF248
Domain Architecture
Description	Zinc finger protein 248.

ZN347_HUMAN
NC score	0.019359 (rank : 320)	θ value	1.81305 (rank : 161)
Query Neighborhood Hits	257	Target Neighborhood Hits	756	Shared Neighborhood Hits	62
SwissProt Accessions	Q96SE7, Q8TCN1	Gene names	ZNF347, ZNF1111
Domain Architecture
Description	Zinc finger protein 347 (Zinc finger protein 1111).

ZN595_HUMAN
NC score	0.019322 (rank : 321)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	257	Target Neighborhood Hits	798	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IYB9	Gene names	ZNF595
Domain Architecture	No domain graphic available
Description	Zinc finger protein 595.

ZNF25_HUMAN
NC score	0.019290 (rank : 322)	θ value	1.38821 (rank : 154)
Query Neighborhood Hits	257	Target Neighborhood Hits	763	Shared Neighborhood Hits	62
SwissProt Accessions	P17030, Q8IYE3, Q8NDD6, Q96MU2	Gene names	ZNF25, KOX19
Domain Architecture
Description	Zinc finger protein 25 (Zinc finger protein KOX19).

ZN11B_HUMAN
NC score	0.019235 (rank : 323)	θ value	8.99809 (rank : 249)
Query Neighborhood Hits	257	Target Neighborhood Hits	802	Shared Neighborhood Hits	70
SwissProt Accessions	Q06732, Q86XY8, Q8NDW3	Gene names	ZNF11B
Domain Architecture	No domain graphic available
Description	Zinc finger protein 11B.

ZN266_HUMAN
NC score	0.019196 (rank : 324)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	64
SwissProt Accessions	Q14584, Q6IQ07, Q6U8A5, Q8IVG3, Q8WVX1, Q96SX9	Gene names	ZNF266, KIAA2007
Domain Architecture	No domain graphic available
Description	Zinc finger protein 266 (Zinc finger protein HZF1).

ZN37A_HUMAN
NC score	0.019157 (rank : 325)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	63
SwissProt Accessions	P17032, Q96B88	Gene names	ZNF37A, KOX21, ZNF37
Domain Architecture	No domain graphic available
Description	Zinc finger protein 37A (Zinc finger protein KOX21).

ZBTB1_HUMAN
NC score	0.019147 (rank : 326)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	257	Target Neighborhood Hits	805	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y2K1, Q86SW8	Gene names	ZBTB1, KIAA0997
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ZN197_HUMAN
NC score	0.019110 (rank : 327)	θ value	1.81305 (rank : 159)
Query Neighborhood Hits	257	Target Neighborhood Hits	788	Shared Neighborhood Hits	62
SwissProt Accessions	O14709	Gene names	ZNF197, ZNF166
Domain Architecture
Description	Zinc finger protein 197 (ZnF20).

ZN267_HUMAN
NC score	0.019106 (rank : 328)	θ value	8.99809 (rank : 254)
Query Neighborhood Hits	257	Target Neighborhood Hits	786	Shared Neighborhood Hits	64
SwissProt Accessions	Q14586, Q8NE41, Q9NRJ0	Gene names	ZNF267
Domain Architecture
Description	Zinc finger protein 267 (Zinc finger protein HZF2).

ZN300_HUMAN
NC score	0.019059 (rank : 329)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	257	Target Neighborhood Hits	748	Shared Neighborhood Hits	64
SwissProt Accessions	Q96RE9	Gene names	ZNF300
Domain Architecture
Description	Zinc finger protein 300.

ZN569_MOUSE
NC score	0.019015 (rank : 330)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	257	Target Neighborhood Hits	758	Shared Neighborhood Hits	60
SwissProt Accessions	Q80W31, O88237	Gene names	Znf569, Zfp74
Domain Architecture	No domain graphic available
Description	Zinc finger protein 569 (Zinc finger protein 74) (Zfp-74) (Mszf21).

ZNF41_HUMAN
NC score	0.019010 (rank : 331)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	257	Target Neighborhood Hits	769	Shared Neighborhood Hits	62
SwissProt Accessions	P51814, Q96LE8, Q9UMC4, Q9UMV5, Q9UMV6, Q9UMV7, Q9UMV8, Q9UMV9, Q9UMW0, Q9UMW1	Gene names	ZNF41
Domain Architecture
Description	Zinc finger protein 41.

ZN691_MOUSE
NC score	0.019005 (rank : 332)	θ value	3.0926 (rank : 178)
Query Neighborhood Hits	257	Target Neighborhood Hits	745	Shared Neighborhood Hits	62
SwissProt Accessions	Q3TDE8, Q3TAT2, Q8BIB1	Gene names	Znf691, Zfp691
Domain Architecture	No domain graphic available
Description	Zinc finger protein 691.

ZNF12_HUMAN
NC score	0.018941 (rank : 333)	θ value	4.03905 (rank : 194)
Query Neighborhood Hits	257	Target Neighborhood Hits	779	Shared Neighborhood Hits	64
SwissProt Accessions	P17014, Q9ULZ6	Gene names	ZNF12, GIOT3, KOX3, ZNF325
Domain Architecture	No domain graphic available
Description	Zinc finger protein 12 (Zinc finger protein KOX3) (Zinc finger protein 325) (Gonadotropin-inducible transcription repressor 3) (GIOT-3).

ZNF26_HUMAN
NC score	0.018863 (rank : 334)	θ value	1.38821 (rank : 155)
Query Neighborhood Hits	257	Target Neighborhood Hits	736	Shared Neighborhood Hits	61
SwissProt Accessions	P17031, Q9NWL3	Gene names	ZNF26, KOX20
Domain Architecture	No domain graphic available
Description	Zinc finger protein 26 (Zinc finger protein KOX20).

ZN682_HUMAN
NC score	0.018829 (rank : 335)	θ value	2.36792 (rank : 170)
Query Neighborhood Hits	257	Target Neighborhood Hits	779	Shared Neighborhood Hits	63
SwissProt Accessions	O95780, Q96JV9	Gene names	ZNF682
Domain Architecture	No domain graphic available
Description	Zinc finger protein 682.

ZN184_HUMAN
NC score	0.018820 (rank : 336)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	257	Target Neighborhood Hits	811	Shared Neighborhood Hits	64
SwissProt Accessions	Q99676, O60792, Q8TBA9	Gene names	ZNF184
Domain Architecture
Description	Zinc finger protein 184.

ZN582_HUMAN
NC score	0.018800 (rank : 337)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	257	Target Neighborhood Hits	738	Shared Neighborhood Hits	62
SwissProt Accessions	Q96NG8, Q6PJT6	Gene names	ZNF582
Domain Architecture	No domain graphic available
Description	Zinc finger protein 582.

ZN611_HUMAN
NC score	0.018783 (rank : 338)	θ value	8.99809 (rank : 257)
Query Neighborhood Hits	257	Target Neighborhood Hits	769	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N823, Q69YG9	Gene names	ZNF611
Domain Architecture	No domain graphic available
Description	Zinc finger protein 611.

ZN135_HUMAN
NC score	0.018685 (rank : 339)	θ value	8.99809 (rank : 251)
Query Neighborhood Hits	257	Target Neighborhood Hits	742	Shared Neighborhood Hits	60
SwissProt Accessions	P52742	Gene names	ZNF135
Domain Architecture	No domain graphic available
Description	Zinc finger protein 135.

ZNF83_HUMAN
NC score	0.018663 (rank : 340)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	257	Target Neighborhood Hits	737	Shared Neighborhood Hits	60
SwissProt Accessions	P51522	Gene names	ZNF83
Domain Architecture	No domain graphic available
Description	Zinc finger protein 83 (Zinc finger protein HPF1).

ZN132_HUMAN
NC score	0.018660 (rank : 341)	θ value	8.99809 (rank : 250)
Query Neighborhood Hits	257	Target Neighborhood Hits	752	Shared Neighborhood Hits	60
SwissProt Accessions	P52740	Gene names	ZNF132
Domain Architecture	No domain graphic available
Description	Zinc finger protein 132.

ZN383_HUMAN
NC score	0.018577 (rank : 342)	θ value	8.99809 (rank : 255)
Query Neighborhood Hits	257	Target Neighborhood Hits	758	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NA42, Q6X2C7	Gene names	ZNF383
Domain Architecture	No domain graphic available
Description	Zinc finger protein 383.

ZN226_HUMAN
NC score	0.018539 (rank : 343)	θ value	8.99809 (rank : 253)
Query Neighborhood Hits	257	Target Neighborhood Hits	770	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NYT6, Q96TE6, Q9NS44	Gene names	ZNF226
Domain Architecture
Description	Zinc finger protein 226.

STK31_HUMAN
NC score	0.018508 (rank : 344)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	257	Target Neighborhood Hits	570	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

ZFP3_HUMAN
NC score	0.018472 (rank : 345)	θ value	8.99809 (rank : 248)
Query Neighborhood Hits	257	Target Neighborhood Hits	750	Shared Neighborhood Hits	62
SwissProt Accessions	Q96NJ6	Gene names	ZFP3
Domain Architecture	No domain graphic available
Description	Zinc finger protein 3 homolog (Zfp-3).

ZBT17_HUMAN
NC score	0.018183 (rank : 346)	θ value	8.99809 (rank : 247)
Query Neighborhood Hits	257	Target Neighborhood Hits	925	Shared Neighborhood Hits	73
SwissProt Accessions	Q13105, Q15932, Q5JYB2, Q9NUC9	Gene names	ZBTB17, MIZ1, ZNF151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Myc-interacting zinc finger protein) (Miz-1 protein).

MYNN_MOUSE
NC score	0.017926 (rank : 347)	θ value	1.81305 (rank : 158)
Query Neighborhood Hits	257	Target Neighborhood Hits	820	Shared Neighborhood Hits	61
SwissProt Accessions	Q99MD8, Q6P1G7, Q8BT55, Q922I4, Q9CSA0, Q9CXJ8	Gene names	Mynn
Domain Architecture	No domain graphic available
Description	Myoneurin.

ACINU_HUMAN
NC score	0.017554 (rank : 348)	θ value	6.88961 (rank : 214)
Query Neighborhood Hits	257	Target Neighborhood Hits	828	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

MYNN_HUMAN
NC score	0.017541 (rank : 349)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	257	Target Neighborhood Hits	826	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NPC7, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NS01, Q9UIW8	Gene names	MYNN, OSZF, ZBTB31
Domain Architecture	No domain graphic available
Description	Myoneurin (Zinc finger and BTB domain-containing protein 31).

OSR2_MOUSE
NC score	0.016881 (rank : 350)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	257	Target Neighborhood Hits	724	Shared Neighborhood Hits	61
SwissProt Accessions	Q91ZD1, Q8BPV6, Q91V54	Gene names	Osr2
Domain Architecture	No domain graphic available
Description	Protein odd-skipped-related 2.

ZN165_HUMAN
NC score	0.016698 (rank : 351)	θ value	8.99809 (rank : 252)
Query Neighborhood Hits	257	Target Neighborhood Hits	734	Shared Neighborhood Hits	60
SwissProt Accessions	P49910	Gene names	ZNF165, ZPF165, ZSCAN7
Domain Architecture
Description	Zinc finger protein 165 (LD65) (Zinc finger and SCAN domain-containing protein 7).

ZBT7B_MOUSE
NC score	0.016674 (rank : 352)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	257	Target Neighborhood Hits	792	Shared Neighborhood Hits	61
SwissProt Accessions	Q64321, Q80VV5	Gene names	Zbtb7b, Thpok, Zfp67
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 7B (Zinc finger protein 67) (Zfp-67) (Zinc finger protein Th-POK) (T-helper-inducing POZ/Krueppel-like factor) (Krueppel-related zinc finger protein cKrox) (c-Krox).

KPCG_HUMAN
NC score	0.016491 (rank : 353)	θ value	0.365318 (rank : 123)
Query Neighborhood Hits	257	Target Neighborhood Hits	1126	Shared Neighborhood Hits	43
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

NCOR2_HUMAN
NC score	0.016013 (rank : 354)	θ value	2.36792 (rank : 164)
Query Neighborhood Hits	257	Target Neighborhood Hits	870	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

KPCG_MOUSE
NC score	0.015246 (rank : 355)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	257	Target Neighborhood Hits	1123	Shared Neighborhood Hits	43
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

CO1A1_MOUSE
NC score	0.015063 (rank : 356)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	257	Target Neighborhood Hits	457	Shared Neighborhood Hits	25
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

GCYB2_HUMAN
NC score	0.013799 (rank : 357)	θ value	1.06291 (rank : 141)
Query Neighborhood Hits	257	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

MAGE1_HUMAN
NC score	0.013359 (rank : 358)	θ value	2.36792 (rank : 163)
Query Neighborhood Hits	257	Target Neighborhood Hits	1389	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CNOT3_MOUSE
NC score	0.012650 (rank : 359)	θ value	6.88961 (rank : 215)
Query Neighborhood Hits	257	Target Neighborhood Hits	504	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CO2A1_HUMAN
NC score	0.012321 (rank : 360)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	257	Target Neighborhood Hits	486	Shared Neighborhood Hits	25
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

C2TA_HUMAN
NC score	0.012097 (rank : 361)	θ value	1.38821 (rank : 145)
Query Neighborhood Hits	257	Target Neighborhood Hits	190	Shared Neighborhood Hits	10
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

MAML1_MOUSE
NC score	0.011812 (rank : 362)	θ value	8.99809 (rank : 241)
Query Neighborhood Hits	257	Target Neighborhood Hits	279	Shared Neighborhood Hits	15
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

SAPS1_HUMAN
NC score	0.011567 (rank : 363)	θ value	5.27518 (rank : 204)
Query Neighborhood Hits	257	Target Neighborhood Hits	704	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

CO2A1_MOUSE
NC score	0.011561 (rank : 364)	θ value	8.99809 (rank : 236)
Query Neighborhood Hits	257	Target Neighborhood Hits	483	Shared Neighborhood Hits	24
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

DUS8_MOUSE
NC score	0.011326 (rank : 365)	θ value	0.47712 (rank : 126)
Query Neighborhood Hits	257	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	O09112	Gene names	Dusp8, Nttp1
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Neuronal tyrosine threonine phosphatase 1).

AR13B_HUMAN
NC score	0.011299 (rank : 366)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	257	Target Neighborhood Hits	528	Shared Neighborhood Hits	18
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

CO1A2_MOUSE
NC score	0.011051 (rank : 367)	θ value	0.62314 (rank : 134)
Query Neighborhood Hits	257	Target Neighborhood Hits	388	Shared Neighborhood Hits	20
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

MVP_HUMAN
NC score	0.009591 (rank : 368)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	257	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q14764, Q96BG4, Q9BPW6, Q9BQT1, Q9UBD1	Gene names	MVP, LRP
Domain Architecture
Description	Major vault protein (MVP) (Lung resistance-related protein).

ZC3H6_MOUSE
NC score	0.009481 (rank : 369)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	257	Target Neighborhood Hits	239	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

SAKS1_MOUSE
NC score	0.009430 (rank : 370)	θ value	8.99809 (rank : 245)
Query Neighborhood Hits	257	Target Neighborhood Hits	208	Shared Neighborhood Hits	9
SwissProt Accessions	Q922Y1, Q3UCP8	Gene names	Saks1, D19Ertd721e
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein) (mY33K) (Protein 2B28).

FMN1A_MOUSE
NC score	0.008724 (rank : 371)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	257	Target Neighborhood Hits	423	Shared Neighborhood Hits	11
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

ATF4_MOUSE
NC score	0.008560 (rank : 372)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	257	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q06507, Q61906	Gene names	Atf4
Domain Architecture	No domain graphic available
Description	Cyclic AMP-dependent transcription factor ATF-4 (C/EBP-related ATF) (C/ATF) (TAXREB67 homolog).

GEMI4_HUMAN
NC score	0.008122 (rank : 373)	θ value	8.99809 (rank : 239)
Query Neighborhood Hits	257	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P57678, Q9NZS7, Q9UG32, Q9Y4Q2	Gene names	GEMIN4
Domain Architecture	No domain graphic available
Description	Component of gems 4 (Gemin-4) (p97).

RASF5_HUMAN
NC score	0.007070 (rank : 374)	θ value	4.03905 (rank : 186)
Query Neighborhood Hits	257	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWW0, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99	Gene names	RASSF5, NORE1, RAPL
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

K0256_MOUSE
NC score	0.006969 (rank : 375)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	257	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q6A098	Gene names	Kiaa0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

FANCA_HUMAN
NC score	0.006959 (rank : 376)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	257	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	O15360, O75266, Q6PL10, Q92497, Q96H18, Q9UEA5, Q9UEL8, Q9UEL9, Q9UPK3, Q9Y6M2	Gene names	FANCA, FAA
Domain Architecture
Description	Fanconi anemia group A protein (Protein FACA).

PEX10_HUMAN
NC score	0.006863 (rank : 377)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	257	Target Neighborhood Hits	255	Shared Neighborhood Hits	7
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

GEMI5_MOUSE
NC score	0.006677 (rank : 378)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	257	Target Neighborhood Hits	424	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

RN125_HUMAN
NC score	0.006471 (rank : 379)	θ value	2.36792 (rank : 166)
Query Neighborhood Hits	257	Target Neighborhood Hits	230	Shared Neighborhood Hits	8
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

MTMR2_MOUSE
NC score	0.006428 (rank : 380)	θ value	8.99809 (rank : 243)
Query Neighborhood Hits	257	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2D1, Q8VHA7	Gene names	Mtmr2
Domain Architecture
Description	Myotubularin-related protein 2 (EC 3.1.3.-).

TR240_HUMAN
NC score	0.005999 (rank : 381)	θ value	8.99809 (rank : 246)
Query Neighborhood Hits	257	Target Neighborhood Hits	99	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHV7, O60334	Gene names	THRAP1, ARC250, KIAA0593, TRAP240
Domain Architecture
Description	Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Thyroid hormone receptor-associated protein 1) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP 250) (Activator-recruited cofactor 250 kDa component) (ARC250).

ARP5_MOUSE
NC score	0.005815 (rank : 382)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	257	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q80US4, Q8BL26	Gene names	Actr5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5.

EP300_HUMAN
NC score	0.005285 (rank : 383)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	257	Target Neighborhood Hits	821	Shared Neighborhood Hits	25
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

TAF5L_HUMAN
NC score	0.004538 (rank : 384)	θ value	2.36792 (rank : 168)
Query Neighborhood Hits	257	Target Neighborhood Hits	330	Shared Neighborhood Hits	9
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

UBQL2_HUMAN
NC score	0.004384 (rank : 385)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	257	Target Neighborhood Hits	103	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UHD9, O94798, Q9H3W6, Q9HAZ4	Gene names	UBQLN2, PLIC2
Domain Architecture
Description	Ubiquilin-2 (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC- 2) (Ubiquitin-like product Chap1/Dsk2) (DSK2 homolog) (Chap1).

TAF5L_MOUSE
NC score	0.004129 (rank : 386)	θ value	2.36792 (rank : 169)
Query Neighborhood Hits	257	Target Neighborhood Hits	337	Shared Neighborhood Hits	9
SwissProt Accessions	Q91WQ5, Q8BTL5	Gene names	Taf5l, Paf65b
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

RBBP6_MOUSE
NC score	0.004002 (rank : 387)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	257	Target Neighborhood Hits	1014	Shared Neighborhood Hits	23
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

PDE1C_HUMAN
NC score	0.003835 (rank : 388)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	257	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
NC score	0.003675 (rank : 389)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	257	Target Neighborhood Hits	161	Shared Neighborhood Hits	7
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

ACE2_HUMAN
NC score	0.003222 (rank : 390)	θ value	8.99809 (rank : 233)
Query Neighborhood Hits	257	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYF1, Q6UWP0, Q86WT0, Q9NRA7, Q9UFZ6	Gene names	ACE2
Domain Architecture	No domain graphic available
Description	Angiotensin-converting enzyme 2 precursor (EC 3.4.17.-) (ACE-related carboxypeptidase) (Angiotensin-converting enzyme homolog) (ACEH).

KLHL1_HUMAN
NC score	0.002153 (rank : 391)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	257	Target Neighborhood Hits	195	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR64, Q5VZ64, Q9H4X4, Q9NR65, Q9P238	Gene names	KLHL1, KIAA1490
Domain Architecture
Description	Kelch-like protein 1.

ROAA_MOUSE
NC score	0.000423 (rank : 392)	θ value	4.03905 (rank : 187)
Query Neighborhood Hits	257	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	Q99020, Q8BPE0	Gene names	Hnrpab, Cbf-a, Cgbfa
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A).

EPHAA_HUMAN
NC score	0.000188 (rank : 393)	θ value	1.06291 (rank : 140)
Query Neighborhood Hits	257	Target Neighborhood Hits	960	Shared Neighborhood Hits	12
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

AATK_MOUSE
NC score	-0.000420 (rank : 394)	θ value	8.99809 (rank : 232)
Query Neighborhood Hits	257	Target Neighborhood Hits	942	Shared Neighborhood Hits	24
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

GPV_HUMAN
NC score	-0.000775 (rank : 395)	θ value	1.81305 (rank : 157)
Query Neighborhood Hits	257	Target Neighborhood Hits	284	Shared Neighborhood Hits	3
SwissProt Accessions	P40197	Gene names	GP5
Domain Architecture
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).