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Network neighborhood for query Sequence : GCYB2_HUMAN

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GCYB2_HUMAN
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GCYB2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	61	Target Neighborhood Hits	61	Shared Neighborhood Hits	61
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GCYB1_HUMAN
θ value	1.71583e-75 (rank : 2)	NC score	0.964164 (rank : 4)
Query Neighborhood Hits	61	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GCYB1_MOUSE
θ value	1.71583e-75 (rank : 3)	NC score	0.964452 (rank : 3)
Query Neighborhood Hits	61	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYA2_HUMAN
θ value	3.23591e-74 (rank : 4)	NC score	0.967677 (rank : 2)
Query Neighborhood Hits	61	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYA3_HUMAN
θ value	2.3998e-69 (rank : 5)	NC score	0.961599 (rank : 5)
Query Neighborhood Hits	61	Target Neighborhood Hits	36	Shared Neighborhood Hits	32
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
θ value	2.3998e-69 (rank : 6)	NC score	0.960985 (rank : 6)
Query Neighborhood Hits	61	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GUC2G_MOUSE
θ value	2.041e-52 (rank : 7)	NC score	0.569097 (rank : 25)
Query Neighborhood Hits	61	Target Neighborhood Hits	644	Shared Neighborhood Hits	31
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ANPRB_HUMAN
θ value	2.25659e-51 (rank : 8)	NC score	0.549701 (rank : 29)
Query Neighborhood Hits	61	Target Neighborhood Hits	646	Shared Neighborhood Hits	33
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
θ value	2.94719e-51 (rank : 9)	NC score	0.556064 (rank : 27)
Query Neighborhood Hits	61	Target Neighborhood Hits	600	Shared Neighborhood Hits	33
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
θ value	6.56568e-51 (rank : 10)	NC score	0.555240 (rank : 28)
Query Neighborhood Hits	61	Target Neighborhood Hits	612	Shared Neighborhood Hits	33
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_MOUSE
θ value	1.11993e-50 (rank : 11)	NC score	0.566875 (rank : 26)
Query Neighborhood Hits	61	Target Neighborhood Hits	607	Shared Neighborhood Hits	33
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2F_HUMAN
θ value	4.25575e-50 (rank : 12)	NC score	0.518341 (rank : 31)
Query Neighborhood Hits	61	Target Neighborhood Hits	740	Shared Neighborhood Hits	32
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2E_MOUSE
θ value	9.48078e-50 (rank : 13)	NC score	0.613792 (rank : 23)
Query Neighborhood Hits	61	Target Neighborhood Hits	692	Shared Neighborhood Hits	31
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2D_HUMAN
θ value	6.7944e-48 (rank : 14)	NC score	0.611661 (rank : 24)
Query Neighborhood Hits	61	Target Neighborhood Hits	715	Shared Neighborhood Hits	31
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2C_HUMAN
θ value	5.38352e-45 (rank : 15)	NC score	0.535120 (rank : 30)
Query Neighborhood Hits	61	Target Neighborhood Hits	624	Shared Neighborhood Hits	33
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

ADCY2_MOUSE
θ value	1.02001e-27 (rank : 16)	NC score	0.803935 (rank : 22)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_HUMAN
θ value	2.27234e-27 (rank : 17)	NC score	0.806484 (rank : 21)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY4_MOUSE
θ value	2.51237e-26 (rank : 18)	NC score	0.811655 (rank : 14)
Query Neighborhood Hits	61	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY4_HUMAN
θ value	3.28125e-26 (rank : 19)	NC score	0.809726 (rank : 18)
Query Neighborhood Hits	61	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY7_MOUSE
θ value	5.59698e-26 (rank : 20)	NC score	0.811164 (rank : 15)
Query Neighborhood Hits	61	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY7_HUMAN
θ value	7.30988e-26 (rank : 21)	NC score	0.810188 (rank : 16)
Query Neighborhood Hits	61	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY6_HUMAN
θ value	1.24688e-25 (rank : 22)	NC score	0.811877 (rank : 13)
Query Neighborhood Hits	61	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_MOUSE
θ value	1.24688e-25 (rank : 23)	NC score	0.809979 (rank : 17)
Query Neighborhood Hits	61	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY3_HUMAN
θ value	4.01107e-24 (rank : 24)	NC score	0.814987 (rank : 12)
Query Neighborhood Hits	61	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY8_HUMAN
θ value	4.01107e-24 (rank : 25)	NC score	0.806976 (rank : 19)
Query Neighborhood Hits	61	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
θ value	4.01107e-24 (rank : 26)	NC score	0.806589 (rank : 20)
Query Neighborhood Hits	61	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY3_MOUSE
θ value	5.23862e-24 (rank : 27)	NC score	0.815798 (rank : 11)
Query Neighborhood Hits	61	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY1_HUMAN
θ value	8.93572e-24 (rank : 28)	NC score	0.818614 (rank : 9)
Query Neighborhood Hits	61	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_MOUSE
θ value	2.59989e-23 (rank : 29)	NC score	0.816085 (rank : 10)
Query Neighborhood Hits	61	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY9_HUMAN
θ value	4.15078e-21 (rank : 30)	NC score	0.822817 (rank : 7)
Query Neighborhood Hits	61	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ADCY9_MOUSE
θ value	4.15078e-21 (rank : 31)	NC score	0.822409 (rank : 8)
Query Neighborhood Hits	61	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

FGD3_HUMAN
θ value	0.163984 (rank : 32)	NC score	0.016409 (rank : 71)
Query Neighborhood Hits	61	Target Neighborhood Hits	249	Shared Neighborhood Hits	6
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

CENPE_HUMAN
θ value	0.21417 (rank : 33)	NC score	0.007193 (rank : 89)
Query Neighborhood Hits	61	Target Neighborhood Hits	2060	Shared Neighborhood Hits	21
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

MD1L1_HUMAN
θ value	0.813845 (rank : 34)	NC score	0.013161 (rank : 78)
Query Neighborhood Hits	61	Target Neighborhood Hits	893	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

FGD3_MOUSE
θ value	1.06291 (rank : 35)	NC score	0.013799 (rank : 77)
Query Neighborhood Hits	61	Target Neighborhood Hits	257	Shared Neighborhood Hits	4
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

TLK2_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.012848 (rank : 80)
Query Neighborhood Hits	61	Target Neighborhood Hits	1044	Shared Neighborhood Hits	17
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	1.38821 (rank : 37)	NC score	0.013048 (rank : 79)
Query Neighborhood Hits	61	Target Neighborhood Hits	1088	Shared Neighborhood Hits	21
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

ERC2_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.010371 (rank : 83)
Query Neighborhood Hits	61	Target Neighborhood Hits	1156	Shared Neighborhood Hits	22
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	1.81305 (rank : 39)	NC score	0.010458 (rank : 82)
Query Neighborhood Hits	61	Target Neighborhood Hits	1166	Shared Neighborhood Hits	23
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

CR034_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.015770 (rank : 72)
Query Neighborhood Hits	61	Target Neighborhood Hits	538	Shared Neighborhood Hits	17
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

STAG1_HUMAN
θ value	2.36792 (rank : 41)	NC score	0.014157 (rank : 76)
Query Neighborhood Hits	61	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WVM7, O00539	Gene names	STAG1, SA1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

STAG1_MOUSE
θ value	2.36792 (rank : 42)	NC score	0.014267 (rank : 75)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D3E6, O08982	Gene names	Stag1, Sa1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

EST1A_HUMAN
θ value	3.0926 (rank : 43)	NC score	0.017470 (rank : 69)
Query Neighborhood Hits	61	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q86US8, O94837, Q86VH6, Q9UF60	Gene names	EST1A, C17orf31, KIAA0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A) (hSmg5/7a).

GCC2_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.008603 (rank : 87)
Query Neighborhood Hits	61	Target Neighborhood Hits	1558	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

NIN_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.009852 (rank : 84)
Query Neighborhood Hits	61	Target Neighborhood Hits	1376	Shared Neighborhood Hits	22
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

RBP24_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.008638 (rank : 86)
Query Neighborhood Hits	61	Target Neighborhood Hits	1559	Shared Neighborhood Hits	20
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

EST1A_MOUSE
θ value	4.03905 (rank : 47)	NC score	0.016472 (rank : 70)
Query Neighborhood Hits	61	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	P61406, Q5NC64	Gene names	Est1a, Kiaa0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A).

GOGA1_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.006610 (rank : 92)
Query Neighborhood Hits	61	Target Neighborhood Hits	1222	Shared Neighborhood Hits	21
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

KCMA1_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.014335 (rank : 74)
Query Neighborhood Hits	61	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

KCMA1_MOUSE
θ value	4.03905 (rank : 50)	NC score	0.014339 (rank : 73)
Query Neighborhood Hits	61	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

CENPF_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.005677 (rank : 94)
Query Neighborhood Hits	61	Target Neighborhood Hits	1932	Shared Neighborhood Hits	25
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

MY18A_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.004041 (rank : 97)
Query Neighborhood Hits	61	Target Neighborhood Hits	1929	Shared Neighborhood Hits	21
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.004988 (rank : 95)
Query Neighborhood Hits	61	Target Neighborhood Hits	1989	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CEP55_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.009125 (rank : 85)
Query Neighborhood Hits	61	Target Neighborhood Hits	693	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

INVO_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.012257 (rank : 81)
Query Neighborhood Hits	61	Target Neighborhood Hits	474	Shared Neighborhood Hits	16
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

KI21B_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.003614 (rank : 98)
Query Neighborhood Hits	61	Target Neighborhood Hits	1017	Shared Neighborhood Hits	16
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

GCC2_MOUSE
θ value	8.99809 (rank : 57)	NC score	0.007640 (rank : 88)
Query Neighborhood Hits	61	Target Neighborhood Hits	1619	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GOGA4_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.004955 (rank : 96)
Query Neighborhood Hits	61	Target Neighborhood Hits	1939	Shared Neighborhood Hits	21
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

MAFK_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.007041 (rank : 91)
Query Neighborhood Hits	61	Target Neighborhood Hits	73	Shared Neighborhood Hits	6
SwissProt Accessions	O60675	Gene names	MAFK
Domain Architecture
Description	Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit).

MAFK_MOUSE
θ value	8.99809 (rank : 60)	NC score	0.007060 (rank : 90)
Query Neighborhood Hits	61	Target Neighborhood Hits	73	Shared Neighborhood Hits	6
SwissProt Accessions	Q61827, Q60600	Gene names	Mafk, Nfe2u
Domain Architecture
Description	Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit).

OPTN_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.005992 (rank : 93)
Query Neighborhood Hits	61	Target Neighborhood Hits	1120	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

ANKK1_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.054055 (rank : 58)
Query Neighborhood Hits	61	Target Neighborhood Hits	1075	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.051575 (rank : 63)
Query Neighborhood Hits	61	Target Neighborhood Hits	1072	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRC_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.290611 (rank : 32)
Query Neighborhood Hits	61	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.284352 (rank : 33)
Query Neighborhood Hits	61	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

GABR1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.081117 (rank : 35)
Query Neighborhood Hits	61	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.083557 (rank : 34)
Query Neighborhood Hits	61	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

ILK1_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.064934 (rank : 48)
Query Neighborhood Hits	61	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.065258 (rank : 47)
Query Neighborhood Hits	61	Target Neighborhood Hits	858	Shared Neighborhood Hits	9
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

IRAK1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.052427 (rank : 59)
Query Neighborhood Hits	61	Target Neighborhood Hits	820	Shared Neighborhood Hits	11
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.051815 (rank : 61)
Query Neighborhood Hits	61	Target Neighborhood Hits	784	Shared Neighborhood Hits	11
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK3_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.080464 (rank : 36)
Query Neighborhood Hits	61	Target Neighborhood Hits	644	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.078040 (rank : 39)
Query Neighborhood Hits	61	Target Neighborhood Hits	628	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.051434 (rank : 64)
Query Neighborhood Hits	61	Target Neighborhood Hits	816	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.050314 (rank : 68)
Query Neighborhood Hits	61	Target Neighborhood Hits	820	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

KSR1_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.077573 (rank : 40)
Query Neighborhood Hits	61	Target Neighborhood Hits	867	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.076591 (rank : 42)
Query Neighborhood Hits	61	Target Neighborhood Hits	870	Shared Neighborhood Hits	11
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.069803 (rank : 44)
Query Neighborhood Hits	61	Target Neighborhood Hits	920	Shared Neighborhood Hits	11
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

M3K12_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.050374 (rank : 66)
Query Neighborhood Hits	61	Target Neighborhood Hits	940	Shared Neighborhood Hits	11
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.050365 (rank : 67)
Query Neighborhood Hits	61	Target Neighborhood Hits	957	Shared Neighborhood Hits	11
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

MLKL_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.077263 (rank : 41)
Query Neighborhood Hits	61	Target Neighborhood Hits	600	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.075939 (rank : 43)
Query Neighborhood Hits	61	Target Neighborhood Hits	707	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.057222 (rank : 54)
Query Neighborhood Hits	61	Target Neighborhood Hits	911	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.057627 (rank : 53)
Query Neighborhood Hits	61	Target Neighborhood Hits	874	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.050522 (rank : 65)
Query Neighborhood Hits	61	Target Neighborhood Hits	829	Shared Neighborhood Hits	11
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

RIPK1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.066946 (rank : 46)
Query Neighborhood Hits	61	Target Neighborhood Hits	891	Shared Neighborhood Hits	11
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.069105 (rank : 45)
Query Neighborhood Hits	61	Target Neighborhood Hits	874	Shared Neighborhood Hits	11
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.079751 (rank : 37)
Query Neighborhood Hits	61	Target Neighborhood Hits	774	Shared Neighborhood Hits	11
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.078082 (rank : 38)
Query Neighborhood Hits	61	Target Neighborhood Hits	776	Shared Neighborhood Hits	11
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.057851 (rank : 52)
Query Neighborhood Hits	61	Target Neighborhood Hits	828	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.059548 (rank : 51)
Query Neighborhood Hits	61	Target Neighborhood Hits	867	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.055120 (rank : 57)
Query Neighborhood Hits	61	Target Neighborhood Hits	1094	Shared Neighborhood Hits	11
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

TESK1_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.052404 (rank : 60)
Query Neighborhood Hits	61	Target Neighborhood Hits	864	Shared Neighborhood Hits	11
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.051709 (rank : 62)
Query Neighborhood Hits	61	Target Neighborhood Hits	862	Shared Neighborhood Hits	11
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.055849 (rank : 56)
Query Neighborhood Hits	61	Target Neighborhood Hits	851	Shared Neighborhood Hits	11
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.055963 (rank : 55)
Query Neighborhood Hits	61	Target Neighborhood Hits	833	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TOPK_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.062649 (rank : 49)
Query Neighborhood Hits	61	Target Neighborhood Hits	605	Shared Neighborhood Hits	11
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.059729 (rank : 50)
Query Neighborhood Hits	61	Target Neighborhood Hits	618	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

Hits sorted by NC score

GCYB2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	61	Target Neighborhood Hits	61	Shared Neighborhood Hits	61
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GCYA2_HUMAN
NC score	0.967677 (rank : 2)	θ value	3.23591e-74 (rank : 4)
Query Neighborhood Hits	61	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYB1_MOUSE
NC score	0.964452 (rank : 3)	θ value	1.71583e-75 (rank : 3)
Query Neighborhood Hits	61	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYB1_HUMAN
NC score	0.964164 (rank : 4)	θ value	1.71583e-75 (rank : 2)
Query Neighborhood Hits	61	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GCYA3_HUMAN
NC score	0.961599 (rank : 5)	θ value	2.3998e-69 (rank : 5)
Query Neighborhood Hits	61	Target Neighborhood Hits	36	Shared Neighborhood Hits	32
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
NC score	0.960985 (rank : 6)	θ value	2.3998e-69 (rank : 6)
Query Neighborhood Hits	61	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

ADCY9_HUMAN
NC score	0.822817 (rank : 7)	θ value	4.15078e-21 (rank : 30)
Query Neighborhood Hits	61	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ADCY9_MOUSE
NC score	0.822409 (rank : 8)	θ value	4.15078e-21 (rank : 31)
Query Neighborhood Hits	61	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY1_HUMAN
NC score	0.818614 (rank : 9)	θ value	8.93572e-24 (rank : 28)
Query Neighborhood Hits	61	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_MOUSE
NC score	0.816085 (rank : 10)	θ value	2.59989e-23 (rank : 29)
Query Neighborhood Hits	61	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY3_MOUSE
NC score	0.815798 (rank : 11)	θ value	5.23862e-24 (rank : 27)
Query Neighborhood Hits	61	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY3_HUMAN
NC score	0.814987 (rank : 12)	θ value	4.01107e-24 (rank : 24)
Query Neighborhood Hits	61	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY6_HUMAN
NC score	0.811877 (rank : 13)	θ value	1.24688e-25 (rank : 22)
Query Neighborhood Hits	61	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY4_MOUSE
NC score	0.811655 (rank : 14)	θ value	2.51237e-26 (rank : 18)
Query Neighborhood Hits	61	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY7_MOUSE
NC score	0.811164 (rank : 15)	θ value	5.59698e-26 (rank : 20)
Query Neighborhood Hits	61	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY7_HUMAN
NC score	0.810188 (rank : 16)	θ value	7.30988e-26 (rank : 21)
Query Neighborhood Hits	61	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY6_MOUSE
NC score	0.809979 (rank : 17)	θ value	1.24688e-25 (rank : 23)
Query Neighborhood Hits	61	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY4_HUMAN
NC score	0.809726 (rank : 18)	θ value	3.28125e-26 (rank : 19)
Query Neighborhood Hits	61	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY8_HUMAN
NC score	0.806976 (rank : 19)	θ value	4.01107e-24 (rank : 25)
Query Neighborhood Hits	61	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
NC score	0.806589 (rank : 20)	θ value	4.01107e-24 (rank : 26)
Query Neighborhood Hits	61	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY2_HUMAN
NC score	0.806484 (rank : 21)	θ value	2.27234e-27 (rank : 17)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_MOUSE
NC score	0.803935 (rank : 22)	θ value	1.02001e-27 (rank : 16)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

GUC2E_MOUSE
NC score	0.613792 (rank : 23)	θ value	9.48078e-50 (rank : 13)
Query Neighborhood Hits	61	Target Neighborhood Hits	692	Shared Neighborhood Hits	31
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2D_HUMAN
NC score	0.611661 (rank : 24)	θ value	6.7944e-48 (rank : 14)
Query Neighborhood Hits	61	Target Neighborhood Hits	715	Shared Neighborhood Hits	31
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
NC score	0.569097 (rank : 25)	θ value	2.041e-52 (rank : 7)
Query Neighborhood Hits	61	Target Neighborhood Hits	644	Shared Neighborhood Hits	31
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ANPRB_MOUSE
NC score	0.566875 (rank : 26)	θ value	1.11993e-50 (rank : 11)
Query Neighborhood Hits	61	Target Neighborhood Hits	607	Shared Neighborhood Hits	33
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
NC score	0.556064 (rank : 27)	θ value	2.94719e-51 (rank : 9)
Query Neighborhood Hits	61	Target Neighborhood Hits	600	Shared Neighborhood Hits	33
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.555240 (rank : 28)	θ value	6.56568e-51 (rank : 10)
Query Neighborhood Hits	61	Target Neighborhood Hits	612	Shared Neighborhood Hits	33
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
NC score	0.549701 (rank : 29)	θ value	2.25659e-51 (rank : 8)
Query Neighborhood Hits	61	Target Neighborhood Hits	646	Shared Neighborhood Hits	33
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2C_HUMAN
NC score	0.535120 (rank : 30)	θ value	5.38352e-45 (rank : 15)
Query Neighborhood Hits	61	Target Neighborhood Hits	624	Shared Neighborhood Hits	33
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2F_HUMAN
NC score	0.518341 (rank : 31)	θ value	4.25575e-50 (rank : 12)
Query Neighborhood Hits	61	Target Neighborhood Hits	740	Shared Neighborhood Hits	32
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ANPRC_HUMAN
NC score	0.290611 (rank : 32)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	61	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
NC score	0.284352 (rank : 33)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	61	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

GABR1_MOUSE
NC score	0.083557 (rank : 34)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	61	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_HUMAN
NC score	0.081117 (rank : 35)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	61	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

IRAK3_HUMAN
NC score	0.080464 (rank : 36)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	61	Target Neighborhood Hits	644	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK2_HUMAN
NC score	0.079751 (rank : 37)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	61	Target Neighborhood Hits	774	Shared Neighborhood Hits	11
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
NC score	0.078082 (rank : 38)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	61	Target Neighborhood Hits	776	Shared Neighborhood Hits	11
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

IRAK3_MOUSE
NC score	0.078040 (rank : 39)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	61	Target Neighborhood Hits	628	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KSR1_HUMAN
NC score	0.077573 (rank : 40)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	61	Target Neighborhood Hits	867	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

MLKL_HUMAN
NC score	0.077263 (rank : 41)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	61	Target Neighborhood Hits	600	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

KSR1_MOUSE
NC score	0.076591 (rank : 42)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	61	Target Neighborhood Hits	870	Shared Neighborhood Hits	11
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MLKL_MOUSE
NC score	0.075939 (rank : 43)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	61	Target Neighborhood Hits	707	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

KSR2_HUMAN
NC score	0.069803 (rank : 44)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	61	Target Neighborhood Hits	920	Shared Neighborhood Hits	11
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

RIPK1_MOUSE
NC score	0.069105 (rank : 45)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	61	Target Neighborhood Hits	874	Shared Neighborhood Hits	11
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_HUMAN
NC score	0.066946 (rank : 46)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	61	Target Neighborhood Hits	891	Shared Neighborhood Hits	11
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ILK_MOUSE
NC score	0.065258 (rank : 47)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	61	Target Neighborhood Hits	858	Shared Neighborhood Hits	9
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.064934 (rank : 48)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	61	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

TOPK_HUMAN
NC score	0.062649 (rank : 49)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	61	Target Neighborhood Hits	605	Shared Neighborhood Hits	11
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
NC score	0.059729 (rank : 50)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	61	Target Neighborhood Hits	618	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

RIPK3_MOUSE
NC score	0.059548 (rank : 51)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	61	Target Neighborhood Hits	867	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK3_HUMAN
NC score	0.057851 (rank : 52)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	61	Target Neighborhood Hits	828	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

MLTK_MOUSE
NC score	0.057627 (rank : 53)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	61	Target Neighborhood Hits	874	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.057222 (rank : 54)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	61	Target Neighborhood Hits	911	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

TESK2_MOUSE
NC score	0.055963 (rank : 55)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	61	Target Neighborhood Hits	833	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_HUMAN
NC score	0.055849 (rank : 56)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	61	Target Neighborhood Hits	851	Shared Neighborhood Hits	11
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

RIPK4_HUMAN
NC score	0.055120 (rank : 57)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	61	Target Neighborhood Hits	1094	Shared Neighborhood Hits	11
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANKK1_HUMAN
NC score	0.054055 (rank : 58)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	61	Target Neighborhood Hits	1075	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

IRAK1_HUMAN
NC score	0.052427 (rank : 59)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	61	Target Neighborhood Hits	820	Shared Neighborhood Hits	11
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TESK1_HUMAN
NC score	0.052404 (rank : 60)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	61	Target Neighborhood Hits	864	Shared Neighborhood Hits	11
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

IRAK1_MOUSE
NC score	0.051815 (rank : 61)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	61	Target Neighborhood Hits	784	Shared Neighborhood Hits	11
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

TESK1_MOUSE
NC score	0.051709 (rank : 62)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	61	Target Neighborhood Hits	862	Shared Neighborhood Hits	11
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

ANKK1_MOUSE
NC score	0.051575 (rank : 63)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	61	Target Neighborhood Hits	1072	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

IRAK4_HUMAN
NC score	0.051434 (rank : 64)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	61	Target Neighborhood Hits	816	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

MOS_HUMAN
NC score	0.050522 (rank : 65)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	61	Target Neighborhood Hits	829	Shared Neighborhood Hits	11
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

M3K12_HUMAN
NC score	0.050374 (rank : 66)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	61	Target Neighborhood Hits	940	Shared Neighborhood Hits	11
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.050365 (rank : 67)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	61	Target Neighborhood Hits	957	Shared Neighborhood Hits	11
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

IRAK4_MOUSE
NC score	0.050314 (rank : 68)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	61	Target Neighborhood Hits	820	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

EST1A_HUMAN
NC score	0.017470 (rank : 69)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	61	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q86US8, O94837, Q86VH6, Q9UF60	Gene names	EST1A, C17orf31, KIAA0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A) (hSmg5/7a).

EST1A_MOUSE
NC score	0.016472 (rank : 70)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	61	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	P61406, Q5NC64	Gene names	Est1a, Kiaa0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A).

FGD3_HUMAN
NC score	0.016409 (rank : 71)	θ value	0.163984 (rank : 32)
Query Neighborhood Hits	61	Target Neighborhood Hits	249	Shared Neighborhood Hits	6
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

CR034_HUMAN
NC score	0.015770 (rank : 72)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	61	Target Neighborhood Hits	538	Shared Neighborhood Hits	17
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

KCMA1_MOUSE
NC score	0.014339 (rank : 73)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	61	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

KCMA1_HUMAN
NC score	0.014335 (rank : 74)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	61	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

STAG1_MOUSE
NC score	0.014267 (rank : 75)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D3E6, O08982	Gene names	Stag1, Sa1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

STAG1_HUMAN
NC score	0.014157 (rank : 76)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	61	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WVM7, O00539	Gene names	STAG1, SA1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

FGD3_MOUSE
NC score	0.013799 (rank : 77)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	61	Target Neighborhood Hits	257	Shared Neighborhood Hits	4
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

MD1L1_HUMAN
NC score	0.013161 (rank : 78)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	61	Target Neighborhood Hits	893	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

TLK2_MOUSE
NC score	0.013048 (rank : 79)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	61	Target Neighborhood Hits	1088	Shared Neighborhood Hits	21
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TLK2_HUMAN
NC score	0.012848 (rank : 80)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	61	Target Neighborhood Hits	1044	Shared Neighborhood Hits	17
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

INVO_MOUSE
NC score	0.012257 (rank : 81)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	61	Target Neighborhood Hits	474	Shared Neighborhood Hits	16
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

ERC2_MOUSE
NC score	0.010458 (rank : 82)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	61	Target Neighborhood Hits	1166	Shared Neighborhood Hits	23
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ERC2_HUMAN
NC score	0.010371 (rank : 83)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	61	Target Neighborhood Hits	1156	Shared Neighborhood Hits	22
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

NIN_MOUSE
NC score	0.009852 (rank : 84)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	61	Target Neighborhood Hits	1376	Shared Neighborhood Hits	22
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

CEP55_MOUSE
NC score	0.009125 (rank : 85)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	61	Target Neighborhood Hits	693	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

RBP24_HUMAN
NC score	0.008638 (rank : 86)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	61	Target Neighborhood Hits	1559	Shared Neighborhood Hits	20
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.008603 (rank : 87)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	61	Target Neighborhood Hits	1558	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GCC2_MOUSE
NC score	0.007640 (rank : 88)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	61	Target Neighborhood Hits	1619	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

CENPE_HUMAN
NC score	0.007193 (rank : 89)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	61	Target Neighborhood Hits	2060	Shared Neighborhood Hits	21
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

MAFK_MOUSE
NC score	0.007060 (rank : 90)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	61	Target Neighborhood Hits	73	Shared Neighborhood Hits	6
SwissProt Accessions	Q61827, Q60600	Gene names	Mafk, Nfe2u
Domain Architecture
Description	Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit).

MAFK_HUMAN
NC score	0.007041 (rank : 91)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	61	Target Neighborhood Hits	73	Shared Neighborhood Hits	6
SwissProt Accessions	O60675	Gene names	MAFK
Domain Architecture
Description	Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit).

GOGA1_HUMAN
NC score	0.006610 (rank : 92)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	61	Target Neighborhood Hits	1222	Shared Neighborhood Hits	21
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

OPTN_MOUSE
NC score	0.005992 (rank : 93)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	61	Target Neighborhood Hits	1120	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

CENPF_HUMAN
NC score	0.005677 (rank : 94)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	61	Target Neighborhood Hits	1932	Shared Neighborhood Hits	25
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

MY18A_MOUSE
NC score	0.004988 (rank : 95)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	61	Target Neighborhood Hits	1989	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

GOGA4_MOUSE
NC score	0.004955 (rank : 96)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	61	Target Neighborhood Hits	1939	Shared Neighborhood Hits	21
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

MY18A_HUMAN
NC score	0.004041 (rank : 97)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	61	Target Neighborhood Hits	1929	Shared Neighborhood Hits	21
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

KI21B_HUMAN
NC score	0.003614 (rank : 98)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	61	Target Neighborhood Hits	1017	Shared Neighborhood Hits	16
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.