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Network neighborhood for query Sequence : ADCY8_HUMAN

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ADCY8_HUMAN
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ADCY1_MOUSE
θ value	0 (rank : 1)	NC score	0.982480 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY3_HUMAN
θ value	0 (rank : 2)	NC score	0.979728 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY6_HUMAN
θ value	0 (rank : 3)	NC score	0.985354 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	52	Shared Neighborhood Hits	33
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_MOUSE
θ value	0 (rank : 4)	NC score	0.984589 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	32
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY8_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
θ value	0 (rank : 6)	NC score	0.999786 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY3_MOUSE
θ value	7.71569e-185 (rank : 7)	NC score	0.978310 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY1_HUMAN
θ value	1.0077e-184 (rank : 8)	NC score	0.979959 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY2_MOUSE
θ value	8.26266e-179 (rank : 9)	NC score	0.978729 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_HUMAN
θ value	1.15563e-172 (rank : 10)	NC score	0.976670 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY4_HUMAN
θ value	1.04765e-165 (rank : 11)	NC score	0.975442 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY7_HUMAN
θ value	2.85304e-163 (rank : 12)	NC score	0.977073 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY4_MOUSE
θ value	1.84928e-162 (rank : 13)	NC score	0.976149 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY7_MOUSE
θ value	8.32034e-155 (rank : 14)	NC score	0.978146 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY9_MOUSE
θ value	4.24587e-58 (rank : 15)	NC score	0.906512 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY9_HUMAN
θ value	1.61343e-57 (rank : 16)	NC score	0.906341 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ANPRA_HUMAN
θ value	2.68423e-28 (rank : 17)	NC score	0.446986 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	612	Shared Neighborhood Hits	32
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	5.97985e-28 (rank : 18)	NC score	0.447974 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	600	Shared Neighborhood Hits	32
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	1.92365e-26 (rank : 19)	NC score	0.442910 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	646	Shared Neighborhood Hits	32
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2E_MOUSE
θ value	1.92365e-26 (rank : 20)	NC score	0.495855 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	692	Shared Neighborhood Hits	32
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

ANPRB_MOUSE
θ value	7.30988e-26 (rank : 21)	NC score	0.455380 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	607	Shared Neighborhood Hits	32
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2F_HUMAN
θ value	1.24688e-25 (rank : 22)	NC score	0.419514 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	740	Shared Neighborhood Hits	32
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GCYB1_HUMAN
θ value	4.01107e-24 (rank : 23)	NC score	0.778624 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GCYB2_HUMAN
θ value	4.01107e-24 (rank : 24)	NC score	0.806976 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GUC2D_HUMAN
θ value	5.23862e-24 (rank : 25)	NC score	0.492262 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GCYB1_MOUSE
θ value	6.84181e-24 (rank : 26)	NC score	0.778812 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GUC2G_MOUSE
θ value	3.39556e-23 (rank : 27)	NC score	0.462578 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	644	Shared Neighborhood Hits	32
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GUC2C_HUMAN
θ value	2.87452e-22 (rank : 28)	NC score	0.434074 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	624	Shared Neighborhood Hits	32
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GCYA2_HUMAN
θ value	4.9032e-22 (rank : 29)	NC score	0.784124 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYA3_HUMAN
θ value	1.86321e-21 (rank : 30)	NC score	0.781393 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
θ value	3.17815e-21 (rank : 31)	NC score	0.779437 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

TM16H_MOUSE
θ value	0.00665767 (rank : 32)	NC score	0.063170 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PB70, Q69ZE4	Gene names	Tmem16h, Kiaa1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

TM16H_HUMAN
θ value	0.0431538 (rank : 33)	NC score	0.054407 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	139	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCE9	Gene names	TMEM16H, KIAA1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

LY10_HUMAN
θ value	1.06291 (rank : 34)	NC score	0.015982 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q13342, Q13341, Q92881, Q96TG3	Gene names	SP140, LYSP100
Domain Architecture
Description	Nuclear body protein SP140 (Nuclear autoantigen Sp-140) (Speckled 140 kDa) (LYSp100 protein) (Lymphoid-restricted homolog of Sp100).

E2AK4_MOUSE
θ value	1.81305 (rank : 35)	NC score	0.014504 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	984	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

TRHY_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.002504 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	1385	Shared Neighborhood Hits	5
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

PHF11_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.009037 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UIL8, Q9Y5A2	Gene names	PHF11, BCAP
Domain Architecture	No domain graphic available
Description	PHD finger protein 11 (BRCA1 C-terminus-associated protein) (NY-REN-34 antigen).

RHBT1_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.006238 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	262	Shared Neighborhood Hits	4
SwissProt Accessions	O94844	Gene names	RHOBTB1, KIAA0740
Domain Architecture
Description	Rho-related BTB domain-containing protein 1.

ANKY1_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.004320 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	248	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

PRDM1_MOUSE
θ value	6.88961 (rank : 40)	NC score	-0.003341 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	766	Shared Neighborhood Hits	3
SwissProt Accessions	Q60636	Gene names	Prdm1, Blimp1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1).

PCLO_MOUSE
θ value	8.99809 (rank : 41)	NC score	-0.003764 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	2275	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ANPRC_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.157765 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.154504 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

Hits sorted by NC score

ADCY8_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
NC score	0.999786 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY6_HUMAN
NC score	0.985354 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	52	Shared Neighborhood Hits	33
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_MOUSE
NC score	0.984589 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	32
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY1_MOUSE
NC score	0.982480 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_HUMAN
NC score	0.979959 (rank : 6)	θ value	1.0077e-184 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY3_HUMAN
NC score	0.979728 (rank : 7)	θ value	0 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY2_MOUSE
NC score	0.978729 (rank : 8)	θ value	8.26266e-179 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY3_MOUSE
NC score	0.978310 (rank : 9)	θ value	7.71569e-185 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY7_MOUSE
NC score	0.978146 (rank : 10)	θ value	8.32034e-155 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY7_HUMAN
NC score	0.977073 (rank : 11)	θ value	2.85304e-163 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY2_HUMAN
NC score	0.976670 (rank : 12)	θ value	1.15563e-172 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY4_MOUSE
NC score	0.976149 (rank : 13)	θ value	1.84928e-162 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY4_HUMAN
NC score	0.975442 (rank : 14)	θ value	1.04765e-165 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY9_MOUSE
NC score	0.906512 (rank : 15)	θ value	4.24587e-58 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY9_HUMAN
NC score	0.906341 (rank : 16)	θ value	1.61343e-57 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

GCYB2_HUMAN
NC score	0.806976 (rank : 17)	θ value	4.01107e-24 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GCYA2_HUMAN
NC score	0.784124 (rank : 18)	θ value	4.9032e-22 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYA3_HUMAN
NC score	0.781393 (rank : 19)	θ value	1.86321e-21 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
NC score	0.779437 (rank : 20)	θ value	3.17815e-21 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYB1_MOUSE
NC score	0.778812 (rank : 21)	θ value	6.84181e-24 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYB1_HUMAN
NC score	0.778624 (rank : 22)	θ value	4.01107e-24 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GUC2E_MOUSE
NC score	0.495855 (rank : 23)	θ value	1.92365e-26 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	692	Shared Neighborhood Hits	32
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2D_HUMAN
NC score	0.492262 (rank : 24)	θ value	5.23862e-24 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
NC score	0.462578 (rank : 25)	θ value	3.39556e-23 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	644	Shared Neighborhood Hits	32
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ANPRB_MOUSE
NC score	0.455380 (rank : 26)	θ value	7.30988e-26 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	607	Shared Neighborhood Hits	32
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
NC score	0.447974 (rank : 27)	θ value	5.97985e-28 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	600	Shared Neighborhood Hits	32
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.446986 (rank : 28)	θ value	2.68423e-28 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	612	Shared Neighborhood Hits	32
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
NC score	0.442910 (rank : 29)	θ value	1.92365e-26 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	646	Shared Neighborhood Hits	32
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2C_HUMAN
NC score	0.434074 (rank : 30)	θ value	2.87452e-22 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	624	Shared Neighborhood Hits	32
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2F_HUMAN
NC score	0.419514 (rank : 31)	θ value	1.24688e-25 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	740	Shared Neighborhood Hits	32
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ANPRC_HUMAN
NC score	0.157765 (rank : 32)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
NC score	0.154504 (rank : 33)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

TM16H_MOUSE
NC score	0.063170 (rank : 34)	θ value	0.00665767 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PB70, Q69ZE4	Gene names	Tmem16h, Kiaa1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

TM16H_HUMAN
NC score	0.054407 (rank : 35)	θ value	0.0431538 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	139	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCE9	Gene names	TMEM16H, KIAA1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

LY10_HUMAN
NC score	0.015982 (rank : 36)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q13342, Q13341, Q92881, Q96TG3	Gene names	SP140, LYSP100
Domain Architecture
Description	Nuclear body protein SP140 (Nuclear autoantigen Sp-140) (Speckled 140 kDa) (LYSp100 protein) (Lymphoid-restricted homolog of Sp100).

E2AK4_MOUSE
NC score	0.014504 (rank : 37)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	984	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

PHF11_HUMAN
NC score	0.009037 (rank : 38)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UIL8, Q9Y5A2	Gene names	PHF11, BCAP
Domain Architecture	No domain graphic available
Description	PHD finger protein 11 (BRCA1 C-terminus-associated protein) (NY-REN-34 antigen).

RHBT1_HUMAN
NC score	0.006238 (rank : 39)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	262	Shared Neighborhood Hits	4
SwissProt Accessions	O94844	Gene names	RHOBTB1, KIAA0740
Domain Architecture
Description	Rho-related BTB domain-containing protein 1.

ANKY1_HUMAN
NC score	0.004320 (rank : 40)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	248	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

TRHY_HUMAN
NC score	0.002504 (rank : 41)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	1385	Shared Neighborhood Hits	5
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

PRDM1_MOUSE
NC score	-0.003341 (rank : 42)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	766	Shared Neighborhood Hits	3
SwissProt Accessions	Q60636	Gene names	Prdm1, Blimp1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1).

PCLO_MOUSE
NC score	-0.003764 (rank : 43)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	2275	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).