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Network neighborhood for query Sequence : PEX13_HUMAN

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PEX13_HUMAN
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PEX13_MOUSE
θ value	1.07914e-178 (rank : 1)	NC score	0.991021 (rank : 2)
Query Neighborhood Hits	128	Target Neighborhood Hits	126	Shared Neighborhood Hits	112
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_HUMAN
θ value	3.83815e-176 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	128	Target Neighborhood Hits	128	Shared Neighborhood Hits	128
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

EFS_HUMAN
θ value	3.41135e-07 (rank : 3)	NC score	0.496026 (rank : 3)
Query Neighborhood Hits	128	Target Neighborhood Hits	348	Shared Neighborhood Hits	107
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	3.41135e-07 (rank : 4)	NC score	0.491014 (rank : 4)
Query Neighborhood Hits	128	Target Neighborhood Hits	389	Shared Neighborhood Hits	110
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PACN3_MOUSE
θ value	1.09739e-05 (rank : 5)	NC score	0.450872 (rank : 9)
Query Neighborhood Hits	128	Target Neighborhood Hits	380	Shared Neighborhood Hits	108
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

BCAR1_HUMAN
θ value	2.44474e-05 (rank : 6)	NC score	0.423531 (rank : 13)
Query Neighborhood Hits	128	Target Neighborhood Hits	554	Shared Neighborhood Hits	110
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	3.19293e-05 (rank : 7)	NC score	0.433092 (rank : 11)
Query Neighborhood Hits	128	Target Neighborhood Hits	438	Shared Neighborhood Hits	107
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PACN3_HUMAN
θ value	3.19293e-05 (rank : 8)	NC score	0.446357 (rank : 10)
Query Neighborhood Hits	128	Target Neighborhood Hits	385	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ARHG7_HUMAN
θ value	7.1131e-05 (rank : 9)	NC score	0.367349 (rank : 25)
Query Neighborhood Hits	128	Target Neighborhood Hits	347	Shared Neighborhood Hits	112
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PACN1_HUMAN
θ value	7.1131e-05 (rank : 10)	NC score	0.453522 (rank : 7)
Query Neighborhood Hits	128	Target Neighborhood Hits	320	Shared Neighborhood Hits	112
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	9.29e-05 (rank : 11)	NC score	0.456206 (rank : 6)
Query Neighborhood Hits	128	Target Neighborhood Hits	283	Shared Neighborhood Hits	112
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	0.000158464 (rank : 12)	NC score	0.456355 (rank : 5)
Query Neighborhood Hits	128	Target Neighborhood Hits	339	Shared Neighborhood Hits	113
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CASL_HUMAN
θ value	0.00020696 (rank : 13)	NC score	0.412103 (rank : 16)
Query Neighborhood Hits	128	Target Neighborhood Hits	259	Shared Neighborhood Hits	100
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0.00020696 (rank : 14)	NC score	0.415548 (rank : 14)
Query Neighborhood Hits	128	Target Neighborhood Hits	225	Shared Neighborhood Hits	102
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

PACN2_MOUSE
θ value	0.00020696 (rank : 15)	NC score	0.451898 (rank : 8)
Query Neighborhood Hits	128	Target Neighborhood Hits	382	Shared Neighborhood Hits	114
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

GRAP2_MOUSE
θ value	0.000602161 (rank : 16)	NC score	0.391475 (rank : 18)
Query Neighborhood Hits	128	Target Neighborhood Hits	297	Shared Neighborhood Hits	110
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB2_HUMAN
θ value	0.000786445 (rank : 17)	NC score	0.386755 (rank : 19)
Query Neighborhood Hits	128	Target Neighborhood Hits	310	Shared Neighborhood Hits	113
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.000786445 (rank : 18)	NC score	0.386329 (rank : 20)
Query Neighborhood Hits	128	Target Neighborhood Hits	312	Shared Neighborhood Hits	113
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ITSN2_HUMAN
θ value	0.000786445 (rank : 19)	NC score	0.265298 (rank : 75)
Query Neighborhood Hits	128	Target Neighborhood Hits	1173	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NEBL_HUMAN
θ value	0.000786445 (rank : 20)	NC score	0.347716 (rank : 38)
Query Neighborhood Hits	128	Target Neighborhood Hits	457	Shared Neighborhood Hits	106
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

RHG26_HUMAN
θ value	0.00134147 (rank : 21)	NC score	0.220001 (rank : 96)
Query Neighborhood Hits	128	Target Neighborhood Hits	281	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CD2AP_MOUSE
θ value	0.00175202 (rank : 22)	NC score	0.413478 (rank : 15)
Query Neighborhood Hits	128	Target Neighborhood Hits	336	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ARHG7_MOUSE
θ value	0.00228821 (rank : 23)	NC score	0.357126 (rank : 32)
Query Neighborhood Hits	128	Target Neighborhood Hits	396	Shared Neighborhood Hits	111
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

NCK1_HUMAN
θ value	0.00228821 (rank : 24)	NC score	0.360146 (rank : 27)
Query Neighborhood Hits	128	Target Neighborhood Hits	312	Shared Neighborhood Hits	109
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

LASP1_HUMAN
θ value	0.00390308 (rank : 25)	NC score	0.359921 (rank : 29)
Query Neighborhood Hits	128	Target Neighborhood Hits	293	Shared Neighborhood Hits	106
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00390308 (rank : 26)	NC score	0.358279 (rank : 31)
Query Neighborhood Hits	128	Target Neighborhood Hits	297	Shared Neighborhood Hits	105
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CD2AP_HUMAN
θ value	0.00509761 (rank : 27)	NC score	0.406730 (rank : 17)
Query Neighborhood Hits	128	Target Neighborhood Hits	315	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

PTK6_HUMAN
θ value	0.00665767 (rank : 28)	NC score	0.098410 (rank : 177)
Query Neighborhood Hits	128	Target Neighborhood Hits	1020	Shared Neighborhood Hits	98
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

CT032_HUMAN
θ value	0.00869519 (rank : 29)	NC score	0.425635 (rank : 12)
Query Neighborhood Hits	128	Target Neighborhood Hits	235	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

GRAP2_HUMAN
θ value	0.00869519 (rank : 30)	NC score	0.372100 (rank : 23)
Query Neighborhood Hits	128	Target Neighborhood Hits	304	Shared Neighborhood Hits	112
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ITSN1_HUMAN
θ value	0.00869519 (rank : 31)	NC score	0.246004 (rank : 82)
Query Neighborhood Hits	128	Target Neighborhood Hits	1757	Shared Neighborhood Hits	119
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NEBU_HUMAN
θ value	0.00869519 (rank : 32)	NC score	0.302034 (rank : 64)
Query Neighborhood Hits	128	Target Neighborhood Hits	420	Shared Neighborhood Hits	108
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

VAV_HUMAN
θ value	0.00869519 (rank : 33)	NC score	0.290452 (rank : 69)
Query Neighborhood Hits	128	Target Neighborhood Hits	452	Shared Neighborhood Hits	110
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

HCK_HUMAN
θ value	0.0113563 (rank : 34)	NC score	0.112010 (rank : 155)
Query Neighborhood Hits	128	Target Neighborhood Hits	1035	Shared Neighborhood Hits	104
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

CSK_HUMAN
θ value	0.0148317 (rank : 35)	NC score	0.098577 (rank : 176)
Query Neighborhood Hits	128	Target Neighborhood Hits	1009	Shared Neighborhood Hits	91
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.0148317 (rank : 36)	NC score	0.098921 (rank : 174)
Query Neighborhood Hits	128	Target Neighborhood Hits	1009	Shared Neighborhood Hits	91
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

IASPP_MOUSE
θ value	0.0148317 (rank : 37)	NC score	0.224568 (rank : 94)
Query Neighborhood Hits	128	Target Neighborhood Hits	1024	Shared Neighborhood Hits	102
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ITSN1_MOUSE
θ value	0.0148317 (rank : 38)	NC score	0.245628 (rank : 83)
Query Neighborhood Hits	128	Target Neighborhood Hits	1669	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NCF4_MOUSE
θ value	0.0148317 (rank : 39)	NC score	0.367942 (rank : 24)
Query Neighborhood Hits	128	Target Neighborhood Hits	177	Shared Neighborhood Hits	95
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SRC_MOUSE
θ value	0.0148317 (rank : 40)	NC score	0.112513 (rank : 154)
Query Neighborhood Hits	128	Target Neighborhood Hits	1033	Shared Neighborhood Hits	104
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

CRKL_HUMAN
θ value	0.0193708 (rank : 41)	NC score	0.332664 (rank : 51)
Query Neighborhood Hits	128	Target Neighborhood Hits	313	Shared Neighborhood Hits	110
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SNX18_HUMAN
θ value	0.0193708 (rank : 42)	NC score	0.309843 (rank : 59)
Query Neighborhood Hits	128	Target Neighborhood Hits	207	Shared Neighborhood Hits	93
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0.0193708 (rank : 43)	NC score	0.314549 (rank : 55)
Query Neighborhood Hits	128	Target Neighborhood Hits	198	Shared Neighborhood Hits	91
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

HCK_MOUSE
θ value	0.0252991 (rank : 44)	NC score	0.110653 (rank : 162)
Query Neighborhood Hits	128	Target Neighborhood Hits	1029	Shared Neighborhood Hits	105
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ITSN2_MOUSE
θ value	0.0252991 (rank : 45)	NC score	0.249175 (rank : 79)
Query Neighborhood Hits	128	Target Neighborhood Hits	1371	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_MOUSE
θ value	0.0252991 (rank : 46)	NC score	0.285690 (rank : 72)
Query Neighborhood Hits	128	Target Neighborhood Hits	430	Shared Neighborhood Hits	112
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

NCK2_HUMAN
θ value	0.0330416 (rank : 47)	NC score	0.340318 (rank : 45)
Query Neighborhood Hits	128	Target Neighborhood Hits	310	Shared Neighborhood Hits	110
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG6_HUMAN
θ value	0.0431538 (rank : 48)	NC score	0.324343 (rank : 53)
Query Neighborhood Hits	128	Target Neighborhood Hits	376	Shared Neighborhood Hits	110
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.0431538 (rank : 49)	NC score	0.326465 (rank : 52)
Query Neighborhood Hits	128	Target Neighborhood Hits	394	Shared Neighborhood Hits	111
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PTK6_MOUSE
θ value	0.0431538 (rank : 50)	NC score	0.096037 (rank : 184)
Query Neighborhood Hits	128	Target Neighborhood Hits	1026	Shared Neighborhood Hits	94
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SH3G2_HUMAN
θ value	0.0431538 (rank : 51)	NC score	0.360097 (rank : 28)
Query Neighborhood Hits	128	Target Neighborhood Hits	324	Shared Neighborhood Hits	111
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	0.0431538 (rank : 52)	NC score	0.356200 (rank : 34)
Query Neighborhood Hits	128	Target Neighborhood Hits	319	Shared Neighborhood Hits	106
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

M3K9_HUMAN
θ value	0.0736092 (rank : 53)	NC score	0.097126 (rank : 181)
Query Neighborhood Hits	128	Target Neighborhood Hits	1123	Shared Neighborhood Hits	107
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

NCF4_HUMAN
θ value	0.0736092 (rank : 54)	NC score	0.344487 (rank : 42)
Query Neighborhood Hits	128	Target Neighborhood Hits	161	Shared Neighborhood Hits	90
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

VINEX_MOUSE
θ value	0.0736092 (rank : 55)	NC score	0.382058 (rank : 21)
Query Neighborhood Hits	128	Target Neighborhood Hits	286	Shared Neighborhood Hits	111
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

IASPP_HUMAN
θ value	0.0961366 (rank : 56)	NC score	0.233032 (rank : 89)
Query Neighborhood Hits	128	Target Neighborhood Hits	688	Shared Neighborhood Hits	97
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SH3G1_HUMAN
θ value	0.0961366 (rank : 57)	NC score	0.338886 (rank : 49)
Query Neighborhood Hits	128	Target Neighborhood Hits	307	Shared Neighborhood Hits	111
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

DNMBP_HUMAN
θ value	0.125558 (rank : 58)	NC score	0.307696 (rank : 61)
Query Neighborhood Hits	128	Target Neighborhood Hits	413	Shared Neighborhood Hits	110
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PPIP1_HUMAN
θ value	0.125558 (rank : 59)	NC score	0.359022 (rank : 30)
Query Neighborhood Hits	128	Target Neighborhood Hits	389	Shared Neighborhood Hits	111
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SH3G1_MOUSE
θ value	0.125558 (rank : 60)	NC score	0.346123 (rank : 39)
Query Neighborhood Hits	128	Target Neighborhood Hits	291	Shared Neighborhood Hits	109
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

DNMBP_MOUSE
θ value	0.163984 (rank : 61)	NC score	0.298320 (rank : 67)
Query Neighborhood Hits	128	Target Neighborhood Hits	435	Shared Neighborhood Hits	113
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRAP_HUMAN
θ value	0.163984 (rank : 62)	NC score	0.349797 (rank : 36)
Query Neighborhood Hits	128	Target Neighborhood Hits	307	Shared Neighborhood Hits	111
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PELP1_MOUSE
θ value	0.163984 (rank : 63)	NC score	0.074050 (rank : 247)
Query Neighborhood Hits	128	Target Neighborhood Hits	709	Shared Neighborhood Hits	17
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PPIP1_MOUSE
θ value	0.163984 (rank : 64)	NC score	0.362686 (rank : 26)
Query Neighborhood Hits	128	Target Neighborhood Hits	377	Shared Neighborhood Hits	113
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SRC_HUMAN
θ value	0.163984 (rank : 65)	NC score	0.119189 (rank : 144)
Query Neighborhood Hits	128	Target Neighborhood Hits	1058	Shared Neighborhood Hits	112
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

VINEX_HUMAN
θ value	0.163984 (rank : 66)	NC score	0.376242 (rank : 22)
Query Neighborhood Hits	128	Target Neighborhood Hits	270	Shared Neighborhood Hits	107
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

GRAP_MOUSE
θ value	0.21417 (rank : 67)	NC score	0.353431 (rank : 35)
Query Neighborhood Hits	128	Target Neighborhood Hits	309	Shared Neighborhood Hits	113
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SH3G3_MOUSE
θ value	0.21417 (rank : 68)	NC score	0.356849 (rank : 33)
Query Neighborhood Hits	128	Target Neighborhood Hits	236	Shared Neighborhood Hits	111
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ABI2_HUMAN
θ value	0.279714 (rank : 69)	NC score	0.338887 (rank : 48)
Query Neighborhood Hits	128	Target Neighborhood Hits	350	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.279714 (rank : 70)	NC score	0.340247 (rank : 46)
Query Neighborhood Hits	128	Target Neighborhood Hits	266	Shared Neighborhood Hits	108
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CRK_HUMAN
θ value	0.365318 (rank : 71)	NC score	0.307759 (rank : 60)
Query Neighborhood Hits	128	Target Neighborhood Hits	308	Shared Neighborhood Hits	110
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.365318 (rank : 72)	NC score	0.314190 (rank : 57)
Query Neighborhood Hits	128	Target Neighborhood Hits	314	Shared Neighborhood Hits	109
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FYN_HUMAN
θ value	0.365318 (rank : 73)	NC score	0.116662 (rank : 148)
Query Neighborhood Hits	128	Target Neighborhood Hits	1078	Shared Neighborhood Hits	112
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.365318 (rank : 74)	NC score	0.118526 (rank : 145)
Query Neighborhood Hits	128	Target Neighborhood Hits	1073	Shared Neighborhood Hits	112
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

NPHP1_MOUSE
θ value	0.365318 (rank : 75)	NC score	0.277876 (rank : 73)
Query Neighborhood Hits	128	Target Neighborhood Hits	267	Shared Neighborhood Hits	105
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STS1_MOUSE
θ value	0.365318 (rank : 76)	NC score	0.160970 (rank : 115)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ASPP1_HUMAN
θ value	0.47712 (rank : 77)	NC score	0.191241 (rank : 103)
Query Neighborhood Hits	128	Target Neighborhood Hits	956	Shared Neighborhood Hits	100
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SPTA1_HUMAN
θ value	0.47712 (rank : 78)	NC score	0.124114 (rank : 138)
Query Neighborhood Hits	128	Target Neighborhood Hits	748	Shared Neighborhood Hits	101
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRC8_MOUSE
θ value	0.47712 (rank : 79)	NC score	0.344982 (rank : 41)
Query Neighborhood Hits	128	Target Neighborhood Hits	292	Shared Neighborhood Hits	109
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAM1_MOUSE
θ value	0.47712 (rank : 80)	NC score	0.303048 (rank : 63)
Query Neighborhood Hits	128	Target Neighborhood Hits	273	Shared Neighborhood Hits	108
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STS1_HUMAN
θ value	0.47712 (rank : 81)	NC score	0.158550 (rank : 117)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SH3G3_HUMAN
θ value	0.62314 (rank : 82)	NC score	0.345705 (rank : 40)
Query Neighborhood Hits	128	Target Neighborhood Hits	222	Shared Neighborhood Hits	110
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CSKI2_HUMAN
θ value	0.813845 (rank : 83)	NC score	0.032726 (rank : 314)
Query Neighborhood Hits	128	Target Neighborhood Hits	747	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

M3K10_HUMAN
θ value	0.813845 (rank : 84)	NC score	0.095905 (rank : 186)
Query Neighborhood Hits	128	Target Neighborhood Hits	1071	Shared Neighborhood Hits	106
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

PRRT3_HUMAN
θ value	0.813845 (rank : 85)	NC score	0.041637 (rank : 311)
Query Neighborhood Hits	128	Target Neighborhood Hits	998	Shared Neighborhood Hits	25
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

STAM1_HUMAN
θ value	0.813845 (rank : 86)	NC score	0.301895 (rank : 65)
Query Neighborhood Hits	128	Target Neighborhood Hits	271	Shared Neighborhood Hits	110
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

VAV3_MOUSE
θ value	0.813845 (rank : 87)	NC score	0.232392 (rank : 91)
Query Neighborhood Hits	128	Target Neighborhood Hits	404	Shared Neighborhood Hits	106
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

P85A_HUMAN
θ value	1.06291 (rank : 88)	NC score	0.131113 (rank : 129)
Query Neighborhood Hits	128	Target Neighborhood Hits	479	Shared Neighborhood Hits	70
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SRMS_MOUSE
θ value	1.06291 (rank : 89)	NC score	0.079211 (rank : 224)
Query Neighborhood Hits	128	Target Neighborhood Hits	964	Shared Neighborhood Hits	71
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

FGR_HUMAN
θ value	1.38821 (rank : 90)	NC score	0.115228 (rank : 152)
Query Neighborhood Hits	128	Target Neighborhood Hits	1067	Shared Neighborhood Hits	107
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC8_HUMAN
θ value	1.38821 (rank : 91)	NC score	0.340973 (rank : 44)
Query Neighborhood Hits	128	Target Neighborhood Hits	269	Shared Neighborhood Hits	109
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ABI1_MOUSE
θ value	1.81305 (rank : 92)	NC score	0.320432 (rank : 54)
Query Neighborhood Hits	128	Target Neighborhood Hits	246	Shared Neighborhood Hits	110
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CSKP_MOUSE
θ value	1.81305 (rank : 93)	NC score	0.038678 (rank : 312)
Query Neighborhood Hits	128	Target Neighborhood Hits	1027	Shared Neighborhood Hits	72
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CBX2_HUMAN
θ value	2.36792 (rank : 94)	NC score	0.021678 (rank : 320)
Query Neighborhood Hits	128	Target Neighborhood Hits	264	Shared Neighborhood Hits	8
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

FRK_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.094500 (rank : 187)
Query Neighborhood Hits	128	Target Neighborhood Hits	1058	Shared Neighborhood Hits	107
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HCLS1_HUMAN
θ value	2.36792 (rank : 96)	NC score	0.348789 (rank : 37)
Query Neighborhood Hits	128	Target Neighborhood Hits	358	Shared Neighborhood Hits	105
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	2.36792 (rank : 97)	NC score	0.340097 (rank : 47)
Query Neighborhood Hits	128	Target Neighborhood Hits	329	Shared Neighborhood Hits	106
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SNX9_MOUSE
θ value	2.36792 (rank : 98)	NC score	0.179144 (rank : 108)
Query Neighborhood Hits	128	Target Neighborhood Hits	141	Shared Neighborhood Hits	65
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

TRAF7_HUMAN
θ value	2.36792 (rank : 99)	NC score	0.012922 (rank : 323)
Query Neighborhood Hits	128	Target Neighborhood Hits	482	Shared Neighborhood Hits	5
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

VAV3_HUMAN
θ value	2.36792 (rank : 100)	NC score	0.231416 (rank : 92)
Query Neighborhood Hits	128	Target Neighborhood Hits	398	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

DBNL_MOUSE
θ value	3.0926 (rank : 101)	NC score	0.290161 (rank : 70)
Query Neighborhood Hits	128	Target Neighborhood Hits	306	Shared Neighborhood Hits	104
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ZN142_HUMAN
θ value	3.0926 (rank : 102)	NC score	-0.001977 (rank : 325)
Query Neighborhood Hits	128	Target Neighborhood Hits	1007	Shared Neighborhood Hits	9
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

AHI1_HUMAN
θ value	4.03905 (rank : 103)	NC score	0.226217 (rank : 93)
Query Neighborhood Hits	128	Target Neighborhood Hits	537	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.222405 (rank : 95)
Query Neighborhood Hits	128	Target Neighborhood Hits	496	Shared Neighborhood Hits	112
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG9_HUMAN
θ value	4.03905 (rank : 105)	NC score	0.208285 (rank : 101)
Query Neighborhood Hits	128	Target Neighborhood Hits	235	Shared Neighborhood Hits	96
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	4.03905 (rank : 106)	NC score	0.207711 (rank : 102)
Query Neighborhood Hits	128	Target Neighborhood Hits	234	Shared Neighborhood Hits	96
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CSKP_HUMAN
θ value	4.03905 (rank : 107)	NC score	0.038389 (rank : 313)
Query Neighborhood Hits	128	Target Neighborhood Hits	1022	Shared Neighborhood Hits	67
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DBNL_HUMAN
θ value	4.03905 (rank : 108)	NC score	0.291048 (rank : 68)
Query Neighborhood Hits	128	Target Neighborhood Hits	244	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

EPN1_MOUSE
θ value	4.03905 (rank : 109)	NC score	0.031695 (rank : 315)
Query Neighborhood Hits	128	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

LYN_MOUSE
θ value	4.03905 (rank : 110)	NC score	0.096176 (rank : 183)
Query Neighborhood Hits	128	Target Neighborhood Hits	1023	Shared Neighborhood Hits	90
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3KL4_HUMAN
θ value	4.03905 (rank : 111)	NC score	0.109652 (rank : 164)
Query Neighborhood Hits	128	Target Neighborhood Hits	1087	Shared Neighborhood Hits	108
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

PCLO_MOUSE
θ value	4.03905 (rank : 112)	NC score	0.024511 (rank : 318)
Query Neighborhood Hits	128	Target Neighborhood Hits	2275	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SPTA2_HUMAN
θ value	4.03905 (rank : 113)	NC score	0.127142 (rank : 133)
Query Neighborhood Hits	128	Target Neighborhood Hits	888	Shared Neighborhood Hits	103
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ABI1_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.301198 (rank : 66)
Query Neighborhood Hits	128	Target Neighborhood Hits	257	Shared Neighborhood Hits	109
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ASPP1_MOUSE
θ value	5.27518 (rank : 115)	NC score	0.175328 (rank : 109)
Query Neighborhood Hits	128	Target Neighborhood Hits	1244	Shared Neighborhood Hits	103
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MILK1_MOUSE
θ value	5.27518 (rank : 116)	NC score	0.015977 (rank : 322)
Query Neighborhood Hits	128	Target Neighborhood Hits	788	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

P85A_MOUSE
θ value	5.27518 (rank : 117)	NC score	0.129603 (rank : 132)
Query Neighborhood Hits	128	Target Neighborhood Hits	435	Shared Neighborhood Hits	74
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CCD71_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.018412 (rank : 321)
Query Neighborhood Hits	128	Target Neighborhood Hits	55	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IV32, Q6IPE2, Q9H8H4, Q9H9F1	Gene names	CCDC71
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 71.

DLG5_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.029565 (rank : 316)
Query Neighborhood Hits	128	Target Neighborhood Hits	1088	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

GLIS1_HUMAN
θ value	6.88961 (rank : 120)	NC score	-0.001931 (rank : 324)
Query Neighborhood Hits	128	Target Neighborhood Hits	748	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

OSTF1_MOUSE
θ value	6.88961 (rank : 121)	NC score	0.243188 (rank : 86)
Query Neighborhood Hits	128	Target Neighborhood Hits	467	Shared Neighborhood Hits	113
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

RGS3_MOUSE
θ value	6.88961 (rank : 122)	NC score	0.021811 (rank : 319)
Query Neighborhood Hits	128	Target Neighborhood Hits	1621	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SNX9_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.175125 (rank : 110)
Query Neighborhood Hits	128	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

ARHG4_HUMAN
θ value	8.99809 (rank : 124)	NC score	0.215134 (rank : 98)
Query Neighborhood Hits	128	Target Neighborhood Hits	242	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

EPN1_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.026277 (rank : 317)
Query Neighborhood Hits	128	Target Neighborhood Hits	206	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

OSTF1_HUMAN
θ value	8.99809 (rank : 126)	NC score	0.244198 (rank : 85)
Query Neighborhood Hits	128	Target Neighborhood Hits	466	Shared Neighborhood Hits	112
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SPTA1_MOUSE
θ value	8.99809 (rank : 127)	NC score	0.118390 (rank : 146)
Query Neighborhood Hits	128	Target Neighborhood Hits	675	Shared Neighborhood Hits	98
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TRIO_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.044364 (rank : 310)
Query Neighborhood Hits	128	Target Neighborhood Hits	1580	Shared Neighborhood Hits	62
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ABI3_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.252921 (rank : 78)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	93
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.246606 (rank : 81)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL1_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.080513 (rank : 221)
Query Neighborhood Hits	128	Target Neighborhood Hits	1220	Shared Neighborhood Hits	85
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.080960 (rank : 220)
Query Neighborhood Hits	128	Target Neighborhood Hits	1178	Shared Neighborhood Hits	84
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.076366 (rank : 236)
Query Neighborhood Hits	128	Target Neighborhood Hits	1045	Shared Neighborhood Hits	72
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

AMPH_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.080378 (rank : 222)
Query Neighborhood Hits	128	Target Neighborhood Hits	455	Shared Neighborhood Hits	58
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.073252 (rank : 250)
Query Neighborhood Hits	128	Target Neighborhood Hits	291	Shared Neighborhood Hits	54
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.140636 (rank : 120)
Query Neighborhood Hits	128	Target Neighborhood Hits	175	Shared Neighborhood Hits	86
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.132148 (rank : 128)
Query Neighborhood Hits	128	Target Neighborhood Hits	175	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APS_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.083607 (rank : 212)
Query Neighborhood Hits	128	Target Neighborhood Hits	162	Shared Neighborhood Hits	31
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.064219 (rank : 267)
Query Neighborhood Hits	128	Target Neighborhood Hits	134	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.056779 (rank : 281)
Query Neighborhood Hits	128	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.052637 (rank : 301)
Query Neighborhood Hits	128	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG3_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.088115 (rank : 200)
Query Neighborhood Hits	128	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.088363 (rank : 199)
Query Neighborhood Hits	128	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.158742 (rank : 116)
Query Neighborhood Hits	128	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.104234 (rank : 169)
Query Neighborhood Hits	128	Target Neighborhood Hits	172	Shared Neighborhood Hits	59
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.078265 (rank : 227)
Query Neighborhood Hits	128	Target Neighborhood Hits	85	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.085819 (rank : 208)
Query Neighborhood Hits	128	Target Neighborhood Hits	79	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.072307 (rank : 252)
Query Neighborhood Hits	128	Target Neighborhood Hits	187	Shared Neighborhood Hits	18
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.075395 (rank : 239)
Query Neighborhood Hits	128	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.055067 (rank : 289)
Query Neighborhood Hits	128	Target Neighborhood Hits	375	Shared Neighborhood Hits	20
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.057304 (rank : 280)
Query Neighborhood Hits	128	Target Neighborhood Hits	351	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.056241 (rank : 286)
Query Neighborhood Hits	128	Target Neighborhood Hits	344	Shared Neighborhood Hits	19
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.054009 (rank : 293)
Query Neighborhood Hits	128	Target Neighborhood Hits	214	Shared Neighborhood Hits	22
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.076904 (rank : 232)
Query Neighborhood Hits	128	Target Neighborhood Hits	129	Shared Neighborhood Hits	32
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.089484 (rank : 195)
Query Neighborhood Hits	128	Target Neighborhood Hits	152	Shared Neighborhood Hits	38
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP2_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.138862 (rank : 122)
Query Neighborhood Hits	128	Target Neighborhood Hits	1156	Shared Neighborhood Hits	96
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAIP2_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.065975 (rank : 261)
Query Neighborhood Hits	128	Target Neighborhood Hits	192	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.068132 (rank : 258)
Query Neighborhood Hits	128	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR3_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.060530 (rank : 276)
Query Neighborhood Hits	128	Target Neighborhood Hits	129	Shared Neighborhood Hits	27
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.059979 (rank : 277)
Query Neighborhood Hits	128	Target Neighborhood Hits	127	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.050640 (rank : 308)
Query Neighborhood Hits	128	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.087300 (rank : 202)
Query Neighborhood Hits	128	Target Neighborhood Hits	156	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.076652 (rank : 234)
Query Neighborhood Hits	128	Target Neighborhood Hits	197	Shared Neighborhood Hits	40
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.083255 (rank : 214)
Query Neighborhood Hits	128	Target Neighborhood Hits	335	Shared Neighborhood Hits	53
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.081019 (rank : 219)
Query Neighborhood Hits	128	Target Neighborhood Hits	283	Shared Neighborhood Hits	54
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.087018 (rank : 205)
Query Neighborhood Hits	128	Target Neighborhood Hits	994	Shared Neighborhood Hits	85
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.084937 (rank : 211)
Query Neighborhood Hits	128	Target Neighborhood Hits	992	Shared Neighborhood Hits	77
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BTK_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.092574 (rank : 191)
Query Neighborhood Hits	128	Target Neighborhood Hits	1026	Shared Neighborhood Hits	107
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.087294 (rank : 203)
Query Neighborhood Hits	128	Target Neighborhood Hits	1017	Shared Neighborhood Hits	98
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CIP4_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.116787 (rank : 147)
Query Neighborhood Hits	128	Target Neighborhood Hits	374	Shared Neighborhood Hits	48
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRKL_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.289353 (rank : 71)
Query Neighborhood Hits	128	Target Neighborhood Hits	307	Shared Neighborhood Hits	105
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.088369 (rank : 198)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.086431 (rank : 207)
Query Neighborhood Hits	128	Target Neighborhood Hits	225	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.135375 (rank : 125)
Query Neighborhood Hits	128	Target Neighborhood Hits	592	Shared Neighborhood Hits	97
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.120049 (rank : 142)
Query Neighborhood Hits	128	Target Neighborhood Hits	599	Shared Neighborhood Hits	93
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.116151 (rank : 149)
Query Neighborhood Hits	128	Target Neighborhood Hits	625	Shared Neighborhood Hits	93
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DOCK1_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.085818 (rank : 209)
Query Neighborhood Hits	128	Target Neighborhood Hits	191	Shared Neighborhood Hits	76
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ECT2_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.065559 (rank : 262)
Query Neighborhood Hits	128	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.068526 (rank : 257)
Query Neighborhood Hits	128	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.054823 (rank : 291)
Query Neighborhood Hits	128	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.052983 (rank : 297)
Query Neighborhood Hits	128	Target Neighborhood Hits	221	Shared Neighborhood Hits	51
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EPS8_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.110513 (rank : 163)
Query Neighborhood Hits	128	Target Neighborhood Hits	151	Shared Neighborhood Hits	70
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.119583 (rank : 143)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.102796 (rank : 171)
Query Neighborhood Hits	128	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.093268 (rank : 189)
Query Neighborhood Hits	128	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.121873 (rank : 140)
Query Neighborhood Hits	128	Target Neighborhood Hits	193	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.115780 (rank : 151)
Query Neighborhood Hits	128	Target Neighborhood Hits	169	Shared Neighborhood Hits	72
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.115843 (rank : 150)
Query Neighborhood Hits	128	Target Neighborhood Hits	206	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.148139 (rank : 119)
Query Neighborhood Hits	128	Target Neighborhood Hits	168	Shared Neighborhood Hits	85
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FER_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.053297 (rank : 295)
Query Neighborhood Hits	128	Target Neighborhood Hits	1278	Shared Neighborhood Hits	47
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGD1_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.051451 (rank : 304)
Query Neighborhood Hits	128	Target Neighborhood Hits	367	Shared Neighborhood Hits	28
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.055807 (rank : 288)
Query Neighborhood Hits	128	Target Neighborhood Hits	151	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.050840 (rank : 307)
Query Neighborhood Hits	128	Target Neighborhood Hits	163	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.053189 (rank : 296)
Query Neighborhood Hits	128	Target Neighborhood Hits	257	Shared Neighborhood Hits	18
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.054987 (rank : 290)
Query Neighborhood Hits	128	Target Neighborhood Hits	219	Shared Neighborhood Hits	19
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.054707 (rank : 292)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGR_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.107209 (rank : 167)
Query Neighborhood Hits	128	Target Neighborhood Hits	1069	Shared Neighborhood Hits	107
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FNBP2_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.110655 (rank : 161)
Query Neighborhood Hits	128	Target Neighborhood Hits	432	Shared Neighborhood Hits	94
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GNRP_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.051409 (rank : 305)
Query Neighborhood Hits	128	Target Neighborhood Hits	239	Shared Neighborhood Hits	16
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.053685 (rank : 294)
Query Neighborhood Hits	128	Target Neighborhood Hits	191	Shared Neighborhood Hits	17
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.063320 (rank : 273)
Query Neighborhood Hits	128	Target Neighborhood Hits	147	Shared Neighborhood Hits	30
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.063819 (rank : 272)
Query Neighborhood Hits	128	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.079745 (rank : 223)
Query Neighborhood Hits	128	Target Neighborhood Hits	137	Shared Neighborhood Hits	30
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.081161 (rank : 217)
Query Neighborhood Hits	128	Target Neighborhood Hits	149	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.067520 (rank : 259)
Query Neighborhood Hits	128	Target Neighborhood Hits	156	Shared Neighborhood Hits	29
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.075378 (rank : 240)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.066090 (rank : 260)
Query Neighborhood Hits	128	Target Neighborhood Hits	350	Shared Neighborhood Hits	22
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HSH2D_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.076826 (rank : 233)
Query Neighborhood Hits	128	Target Neighborhood Hits	159	Shared Neighborhood Hits	25
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.051981 (rank : 302)
Query Neighborhood Hits	128	Target Neighborhood Hits	124	Shared Neighborhood Hits	19
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ITK_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.069178 (rank : 254)
Query Neighborhood Hits	128	Target Neighborhood Hits	1016	Shared Neighborhood Hits	83
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.064894 (rank : 264)
Query Neighborhood Hits	128	Target Neighborhood Hits	985	Shared Neighborhood Hits	72
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LBC_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.056299 (rank : 285)
Query Neighborhood Hits	128	Target Neighborhood Hits	90	Shared Neighborhood Hits	16
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.083520 (rank : 213)
Query Neighborhood Hits	128	Target Neighborhood Hits	987	Shared Neighborhood Hits	73
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.082553 (rank : 215)
Query Neighborhood Hits	128	Target Neighborhood Hits	981	Shared Neighborhood Hits	73
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.056527 (rank : 283)
Query Neighborhood Hits	128	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.073576 (rank : 249)
Query Neighborhood Hits	128	Target Neighborhood Hits	151	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.073746 (rank : 248)
Query Neighborhood Hits	128	Target Neighborhood Hits	132	Shared Neighborhood Hits	27
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LYN_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.093275 (rank : 188)
Query Neighborhood Hits	128	Target Neighborhood Hits	1022	Shared Neighborhood Hits	93
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K11_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.098776 (rank : 175)
Query Neighborhood Hits	128	Target Neighborhood Hits	1136	Shared Neighborhood Hits	108
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MATK_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.064109 (rank : 270)
Query Neighborhood Hits	128	Target Neighborhood Hits	954	Shared Neighborhood Hits	51
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.064236 (rank : 266)
Query Neighborhood Hits	128	Target Neighborhood Hits	952	Shared Neighborhood Hits	54
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.088749 (rank : 197)
Query Neighborhood Hits	128	Target Neighborhood Hits	255	Shared Neighborhood Hits	36
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.074100 (rank : 246)
Query Neighborhood Hits	128	Target Neighborhood Hits	166	Shared Neighborhood Hits	21
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MPP6_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.051453 (rank : 303)
Query Neighborhood Hits	128	Target Neighborhood Hits	180	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MYO1E_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.121727 (rank : 141)
Query Neighborhood Hits	128	Target Neighborhood Hits	293	Shared Neighborhood Hits	109
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.129980 (rank : 130)
Query Neighborhood Hits	128	Target Neighborhood Hits	275	Shared Neighborhood Hits	105
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.129635 (rank : 131)
Query Neighborhood Hits	128	Target Neighborhood Hits	262	Shared Neighborhood Hits	104
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.248910 (rank : 80)
Query Neighborhood Hits	128	Target Neighborhood Hits	198	Shared Neighborhood Hits	90
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.242033 (rank : 87)
Query Neighborhood Hits	128	Target Neighborhood Hits	198	Shared Neighborhood Hits	95
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.303062 (rank : 62)
Query Neighborhood Hits	128	Target Neighborhood Hits	229	Shared Neighborhood Hits	99
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NGEF_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.085782 (rank : 210)
Query Neighborhood Hits	128	Target Neighborhood Hits	166	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.090034 (rank : 194)
Query Neighborhood Hits	128	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.110757 (rank : 160)
Query Neighborhood Hits	128	Target Neighborhood Hits	100	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.168877 (rank : 112)
Query Neighborhood Hits	128	Target Neighborhood Hits	114	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.218929 (rank : 97)
Query Neighborhood Hits	128	Target Neighborhood Hits	288	Shared Neighborhood Hits	96
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NRAP_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.063942 (rank : 271)
Query Neighborhood Hits	128	Target Neighborhood Hits	159	Shared Neighborhood Hits	6
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NRAP_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.064363 (rank : 265)
Query Neighborhood Hits	128	Target Neighborhood Hits	167	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

P55G_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.086615 (rank : 206)
Query Neighborhood Hits	128	Target Neighborhood Hits	451	Shared Neighborhood Hits	38
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.082335 (rank : 216)
Query Neighborhood Hits	128	Target Neighborhood Hits	401	Shared Neighborhood Hits	36
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.101205 (rank : 172)
Query Neighborhood Hits	128	Target Neighborhood Hits	543	Shared Neighborhood Hits	56
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.098094 (rank : 178)
Query Neighborhood Hits	128	Target Neighborhood Hits	519	Shared Neighborhood Hits	52
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PKHG1_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.097728 (rank : 180)
Query Neighborhood Hits	128	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.050842 (rank : 306)
Query Neighborhood Hits	128	Target Neighborhood Hits	200	Shared Neighborhood Hits	15
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.185220 (rank : 106)
Query Neighborhood Hits	128	Target Neighborhood Hits	293	Shared Neighborhood Hits	95
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.191098 (rank : 104)
Query Neighborhood Hits	128	Target Neighborhood Hits	314	Shared Neighborhood Hits	99
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.190303 (rank : 105)
Query Neighborhood Hits	128	Target Neighborhood Hits	280	Shared Neighborhood Hits	93
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP2_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.104919 (rank : 168)
Query Neighborhood Hits	128	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.091670 (rank : 192)
Query Neighborhood Hits	128	Target Neighborhood Hits	308	Shared Neighborhood Hits	15
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.087852 (rank : 201)
Query Neighborhood Hits	128	Target Neighborhood Hits	177	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTN11_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.052877 (rank : 300)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.052884 (rank : 298)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

RASA1_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.111733 (rank : 158)
Query Neighborhood Hits	128	Target Neighborhood Hits	258	Shared Neighborhood Hits	43
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RGNEF_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.050398 (rank : 309)
Query Neighborhood Hits	128	Target Neighborhood Hits	641	Shared Neighborhood Hits	23
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG04_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.148656 (rank : 118)
Query Neighborhood Hits	128	Target Neighborhood Hits	307	Shared Neighborhood Hits	98
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.096557 (rank : 182)
Query Neighborhood Hits	128	Target Neighborhood Hits	1479	Shared Neighborhood Hits	95
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.090052 (rank : 193)
Query Neighborhood Hits	128	Target Neighborhood Hits	1376	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.172245 (rank : 111)
Query Neighborhood Hits	128	Target Neighborhood Hits	263	Shared Neighborhood Hits	83
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.162829 (rank : 113)
Query Neighborhood Hits	128	Target Neighborhood Hits	246	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.182852 (rank : 107)
Query Neighborhood Hits	128	Target Neighborhood Hits	226	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.162204 (rank : 114)
Query Neighborhood Hits	128	Target Neighborhood Hits	206	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.069254 (rank : 253)
Query Neighborhood Hits	128	Target Neighborhood Hits	205	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.057705 (rank : 279)
Query Neighborhood Hits	128	Target Neighborhood Hits	305	Shared Neighborhood Hits	45
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SH21A_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.064111 (rank : 269)
Query Neighborhood Hits	128	Target Neighborhood Hits	89	Shared Neighborhood Hits	19
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.062922 (rank : 274)
Query Neighborhood Hits	128	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.097987 (rank : 179)
Query Neighborhood Hits	128	Target Neighborhood Hits	101	Shared Neighborhood Hits	23
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.103192 (rank : 170)
Query Neighborhood Hits	128	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.056518 (rank : 284)
Query Neighborhood Hits	128	Target Neighborhood Hits	179	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.056573 (rank : 282)
Query Neighborhood Hits	128	Target Neighborhood Hits	149	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.064125 (rank : 268)
Query Neighborhood Hits	128	Target Neighborhood Hits	455	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH2D3_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.055946 (rank : 287)
Query Neighborhood Hits	128	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.057769 (rank : 278)
Query Neighborhood Hits	128	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3K1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.341423 (rank : 43)
Query Neighborhood Hits	128	Target Neighborhood Hits	341	Shared Neighborhood Hits	108
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.338324 (rank : 50)
Query Neighborhood Hits	128	Target Neighborhood Hits	332	Shared Neighborhood Hits	109
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.075124 (rank : 241)
Query Neighborhood Hits	128	Target Neighborhood Hits	1041	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.096016 (rank : 185)
Query Neighborhood Hits	128	Target Neighborhood Hits	446	Shared Neighborhood Hits	69
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.078545 (rank : 225)
Query Neighborhood Hits	128	Target Neighborhood Hits	141	Shared Neighborhood Hits	31
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.081084 (rank : 218)
Query Neighborhood Hits	128	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.078098 (rank : 228)
Query Neighborhood Hits	128	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.076370 (rank : 235)
Query Neighborhood Hits	128	Target Neighborhood Hits	180	Shared Neighborhood Hits	32
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.074729 (rank : 243)
Query Neighborhood Hits	128	Target Neighborhood Hits	170	Shared Neighborhood Hits	31
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.074537 (rank : 244)
Query Neighborhood Hits	128	Target Neighborhood Hits	144	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.068558 (rank : 256)
Query Neighborhood Hits	128	Target Neighborhood Hits	155	Shared Neighborhood Hits	29
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.077531 (rank : 230)
Query Neighborhood Hits	128	Target Neighborhood Hits	151	Shared Neighborhood Hits	31
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.076188 (rank : 237)
Query Neighborhood Hits	128	Target Neighborhood Hits	204	Shared Neighborhood Hits	29
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.078042 (rank : 229)
Query Neighborhood Hits	128	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.075642 (rank : 238)
Query Neighborhood Hits	128	Target Neighborhood Hits	164	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.078410 (rank : 226)
Query Neighborhood Hits	128	Target Neighborhood Hits	169	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.125872 (rank : 135)
Query Neighborhood Hits	128	Target Neighborhood Hits	96	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.134277 (rank : 126)
Query Neighborhood Hits	128	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.111479 (rank : 159)
Query Neighborhood Hits	128	Target Neighborhood Hits	86	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.111740 (rank : 157)
Query Neighborhood Hits	128	Target Neighborhood Hits	88	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.126207 (rank : 134)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.125022 (rank : 137)
Query Neighborhood Hits	128	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.140433 (rank : 121)
Query Neighborhood Hits	128	Target Neighborhood Hits	139	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.137905 (rank : 123)
Query Neighborhood Hits	128	Target Neighborhood Hits	136	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.060739 (rank : 275)
Query Neighborhood Hits	128	Target Neighborhood Hits	81	Shared Neighborhood Hits	36
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.068915 (rank : 255)
Query Neighborhood Hits	128	Target Neighborhood Hits	108	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SOCS7_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.052880 (rank : 299)
Query Neighborhood Hits	128	Target Neighborhood Hits	154	Shared Neighborhood Hits	29
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPN90_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.133835 (rank : 127)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.111746 (rank : 156)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.310667 (rank : 58)
Query Neighborhood Hits	128	Target Neighborhood Hits	396	Shared Neighborhood Hits	113
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.314465 (rank : 56)
Query Neighborhood Hits	128	Target Neighborhood Hits	409	Shared Neighborhood Hits	112
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRGP1_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.112626 (rank : 153)
Query Neighborhood Hits	128	Target Neighborhood Hits	390	Shared Neighborhood Hits	91
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.123663 (rank : 139)
Query Neighborhood Hits	128	Target Neighborhood Hits	331	Shared Neighborhood Hits	91
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.125124 (rank : 136)
Query Neighborhood Hits	128	Target Neighborhood Hits	324	Shared Neighborhood Hits	92
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.065468 (rank : 263)
Query Neighborhood Hits	128	Target Neighborhood Hits	946	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

STAC3_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.209833 (rank : 100)
Query Neighborhood Hits	128	Target Neighborhood Hits	228	Shared Neighborhood Hits	90
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.211133 (rank : 99)
Query Neighborhood Hits	128	Target Neighborhood Hits	232	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.255055 (rank : 77)
Query Neighborhood Hits	128	Target Neighborhood Hits	276	Shared Neighborhood Hits	102
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.245549 (rank : 84)
Query Neighborhood Hits	128	Target Neighborhood Hits	268	Shared Neighborhood Hits	104
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM2_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.260719 (rank : 76)
Query Neighborhood Hits	128	Target Neighborhood Hits	288	Shared Neighborhood Hits	107
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.275113 (rank : 74)
Query Neighborhood Hits	128	Target Neighborhood Hits	285	Shared Neighborhood Hits	104
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STS2_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.135459 (rank : 124)
Query Neighborhood Hits	128	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCGAP_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.093072 (rank : 190)
Query Neighborhood Hits	128	Target Neighborhood Hits	872	Shared Neighborhood Hits	85
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.100215 (rank : 173)
Query Neighborhood Hits	128	Target Neighborhood Hits	409	Shared Neighborhood Hits	79
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TEC_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.074977 (rank : 242)
Query Neighborhood Hits	128	Target Neighborhood Hits	1006	Shared Neighborhood Hits	82
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.074242 (rank : 245)
Query Neighborhood Hits	128	Target Neighborhood Hits	1006	Shared Neighborhood Hits	84
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TIAM1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.087213 (rank : 204)
Query Neighborhood Hits	128	Target Neighborhood Hits	225	Shared Neighborhood Hits	20
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.089073 (rank : 196)
Query Neighborhood Hits	128	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TXK_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.072413 (rank : 251)
Query Neighborhood Hits	128	Target Neighborhood Hits	971	Shared Neighborhood Hits	75
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.077046 (rank : 231)
Query Neighborhood Hits	128	Target Neighborhood Hits	980	Shared Neighborhood Hits	82
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

VAV2_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.233054 (rank : 88)
Query Neighborhood Hits	128	Target Neighborhood Hits	453	Shared Neighborhood Hits	109
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.232668 (rank : 90)
Query Neighborhood Hits	128	Target Neighborhood Hits	456	Shared Neighborhood Hits	109
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

YES_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.108254 (rank : 166)
Query Neighborhood Hits	128	Target Neighborhood Hits	1059	Shared Neighborhood Hits	109
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.109351 (rank : 165)
Query Neighborhood Hits	128	Target Neighborhood Hits	1052	Shared Neighborhood Hits	109
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

Hits sorted by NC score

PEX13_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.83815e-176 (rank : 2)
Query Neighborhood Hits	128	Target Neighborhood Hits	128	Shared Neighborhood Hits	128
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
NC score	0.991021 (rank : 2)	θ value	1.07914e-178 (rank : 1)
Query Neighborhood Hits	128	Target Neighborhood Hits	126	Shared Neighborhood Hits	112
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

EFS_HUMAN
NC score	0.496026 (rank : 3)	θ value	3.41135e-07 (rank : 3)
Query Neighborhood Hits	128	Target Neighborhood Hits	348	Shared Neighborhood Hits	107
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
NC score	0.491014 (rank : 4)	θ value	3.41135e-07 (rank : 4)
Query Neighborhood Hits	128	Target Neighborhood Hits	389	Shared Neighborhood Hits	110
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PACN2_HUMAN
NC score	0.456355 (rank : 5)	θ value	0.000158464 (rank : 12)
Query Neighborhood Hits	128	Target Neighborhood Hits	339	Shared Neighborhood Hits	113
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_MOUSE
NC score	0.456206 (rank : 6)	θ value	9.29e-05 (rank : 11)
Query Neighborhood Hits	128	Target Neighborhood Hits	283	Shared Neighborhood Hits	112
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.453522 (rank : 7)	θ value	7.1131e-05 (rank : 10)
Query Neighborhood Hits	128	Target Neighborhood Hits	320	Shared Neighborhood Hits	112
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_MOUSE
NC score	0.451898 (rank : 8)	θ value	0.00020696 (rank : 15)
Query Neighborhood Hits	128	Target Neighborhood Hits	382	Shared Neighborhood Hits	114
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_MOUSE
NC score	0.450872 (rank : 9)	θ value	1.09739e-05 (rank : 5)
Query Neighborhood Hits	128	Target Neighborhood Hits	380	Shared Neighborhood Hits	108
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.446357 (rank : 10)	θ value	3.19293e-05 (rank : 8)
Query Neighborhood Hits	128	Target Neighborhood Hits	385	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

BCAR1_MOUSE
NC score	0.433092 (rank : 11)	θ value	3.19293e-05 (rank : 7)
Query Neighborhood Hits	128	Target Neighborhood Hits	438	Shared Neighborhood Hits	107
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CT032_HUMAN
NC score	0.425635 (rank : 12)	θ value	0.00869519 (rank : 29)
Query Neighborhood Hits	128	Target Neighborhood Hits	235	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

BCAR1_HUMAN
NC score	0.423531 (rank : 13)	θ value	2.44474e-05 (rank : 6)
Query Neighborhood Hits	128	Target Neighborhood Hits	554	Shared Neighborhood Hits	110
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_MOUSE
NC score	0.415548 (rank : 14)	θ value	0.00020696 (rank : 14)
Query Neighborhood Hits	128	Target Neighborhood Hits	225	Shared Neighborhood Hits	102
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_MOUSE
NC score	0.413478 (rank : 15)	θ value	0.00175202 (rank : 22)
Query Neighborhood Hits	128	Target Neighborhood Hits	336	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CASL_HUMAN
NC score	0.412103 (rank : 16)	θ value	0.00020696 (rank : 13)
Query Neighborhood Hits	128	Target Neighborhood Hits	259	Shared Neighborhood Hits	100
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CD2AP_HUMAN
NC score	0.406730 (rank : 17)	θ value	0.00509761 (rank : 27)
Query Neighborhood Hits	128	Target Neighborhood Hits	315	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

GRAP2_MOUSE
NC score	0.391475 (rank : 18)	θ value	0.000602161 (rank : 16)
Query Neighborhood Hits	128	Target Neighborhood Hits	297	Shared Neighborhood Hits	110
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB2_HUMAN
NC score	0.386755 (rank : 19)	θ value	0.000786445 (rank : 17)
Query Neighborhood Hits	128	Target Neighborhood Hits	310	Shared Neighborhood Hits	113
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.386329 (rank : 20)	θ value	0.000786445 (rank : 18)
Query Neighborhood Hits	128	Target Neighborhood Hits	312	Shared Neighborhood Hits	113
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

VINEX_MOUSE
NC score	0.382058 (rank : 21)	θ value	0.0736092 (rank : 55)
Query Neighborhood Hits	128	Target Neighborhood Hits	286	Shared Neighborhood Hits	111
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.376242 (rank : 22)	θ value	0.163984 (rank : 66)
Query Neighborhood Hits	128	Target Neighborhood Hits	270	Shared Neighborhood Hits	107
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

GRAP2_HUMAN
NC score	0.372100 (rank : 23)	θ value	0.00869519 (rank : 30)
Query Neighborhood Hits	128	Target Neighborhood Hits	304	Shared Neighborhood Hits	112
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCF4_MOUSE
NC score	0.367942 (rank : 24)	θ value	0.0148317 (rank : 39)
Query Neighborhood Hits	128	Target Neighborhood Hits	177	Shared Neighborhood Hits	95
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ARHG7_HUMAN
NC score	0.367349 (rank : 25)	θ value	7.1131e-05 (rank : 9)
Query Neighborhood Hits	128	Target Neighborhood Hits	347	Shared Neighborhood Hits	112
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PPIP1_MOUSE
NC score	0.362686 (rank : 26)	θ value	0.163984 (rank : 64)
Query Neighborhood Hits	128	Target Neighborhood Hits	377	Shared Neighborhood Hits	113
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

NCK1_HUMAN
NC score	0.360146 (rank : 27)	θ value	0.00228821 (rank : 24)
Query Neighborhood Hits	128	Target Neighborhood Hits	312	Shared Neighborhood Hits	109
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3G2_HUMAN
NC score	0.360097 (rank : 28)	θ value	0.0431538 (rank : 51)
Query Neighborhood Hits	128	Target Neighborhood Hits	324	Shared Neighborhood Hits	111
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

LASP1_HUMAN
NC score	0.359921 (rank : 29)	θ value	0.00390308 (rank : 25)
Query Neighborhood Hits	128	Target Neighborhood Hits	293	Shared Neighborhood Hits	106
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PPIP1_HUMAN
NC score	0.359022 (rank : 30)	θ value	0.125558 (rank : 59)
Query Neighborhood Hits	128	Target Neighborhood Hits	389	Shared Neighborhood Hits	111
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

LASP1_MOUSE
NC score	0.358279 (rank : 31)	θ value	0.00390308 (rank : 26)
Query Neighborhood Hits	128	Target Neighborhood Hits	297	Shared Neighborhood Hits	105
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ARHG7_MOUSE
NC score	0.357126 (rank : 32)	θ value	0.00228821 (rank : 23)
Query Neighborhood Hits	128	Target Neighborhood Hits	396	Shared Neighborhood Hits	111
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

SH3G3_MOUSE
NC score	0.356849 (rank : 33)	θ value	0.21417 (rank : 68)
Query Neighborhood Hits	128	Target Neighborhood Hits	236	Shared Neighborhood Hits	111
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G2_MOUSE
NC score	0.356200 (rank : 34)	θ value	0.0431538 (rank : 52)
Query Neighborhood Hits	128	Target Neighborhood Hits	319	Shared Neighborhood Hits	106
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

GRAP_MOUSE
NC score	0.353431 (rank : 35)	θ value	0.21417 (rank : 67)
Query Neighborhood Hits	128	Target Neighborhood Hits	309	Shared Neighborhood Hits	113
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.349797 (rank : 36)	θ value	0.163984 (rank : 62)
Query Neighborhood Hits	128	Target Neighborhood Hits	307	Shared Neighborhood Hits	111
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

HCLS1_HUMAN
NC score	0.348789 (rank : 37)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	128	Target Neighborhood Hits	358	Shared Neighborhood Hits	105
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NEBL_HUMAN
NC score	0.347716 (rank : 38)	θ value	0.000786445 (rank : 20)
Query Neighborhood Hits	128	Target Neighborhood Hits	457	Shared Neighborhood Hits	106
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SH3G1_MOUSE
NC score	0.346123 (rank : 39)	θ value	0.125558 (rank : 60)
Query Neighborhood Hits	128	Target Neighborhood Hits	291	Shared Neighborhood Hits	109
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
NC score	0.345705 (rank : 40)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	128	Target Neighborhood Hits	222	Shared Neighborhood Hits	110
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRC8_MOUSE
NC score	0.344982 (rank : 41)	θ value	0.47712 (rank : 79)
Query Neighborhood Hits	128	Target Neighborhood Hits	292	Shared Neighborhood Hits	109
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

NCF4_HUMAN
NC score	0.344487 (rank : 42)	θ value	0.0736092 (rank : 54)
Query Neighborhood Hits	128	Target Neighborhood Hits	161	Shared Neighborhood Hits	90
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SH3K1_HUMAN
NC score	0.341423 (rank : 43)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	128	Target Neighborhood Hits	341	Shared Neighborhood Hits	108
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SRC8_HUMAN
NC score	0.340973 (rank : 44)	θ value	1.38821 (rank : 91)
Query Neighborhood Hits	128	Target Neighborhood Hits	269	Shared Neighborhood Hits	109
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

NCK2_HUMAN
NC score	0.340318 (rank : 45)	θ value	0.0330416 (rank : 47)
Query Neighborhood Hits	128	Target Neighborhood Hits	310	Shared Neighborhood Hits	110
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ABI2_MOUSE
NC score	0.340247 (rank : 46)	θ value	0.279714 (rank : 70)
Query Neighborhood Hits	128	Target Neighborhood Hits	266	Shared Neighborhood Hits	108
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

HCLS1_MOUSE
NC score	0.340097 (rank : 47)	θ value	2.36792 (rank : 97)
Query Neighborhood Hits	128	Target Neighborhood Hits	329	Shared Neighborhood Hits	106
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI2_HUMAN
NC score	0.338887 (rank : 48)	θ value	0.279714 (rank : 69)
Query Neighborhood Hits	128	Target Neighborhood Hits	350	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SH3G1_HUMAN
NC score	0.338886 (rank : 49)	θ value	0.0961366 (rank : 57)
Query Neighborhood Hits	128	Target Neighborhood Hits	307	Shared Neighborhood Hits	111
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3K1_MOUSE
NC score	0.338324 (rank : 50)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	128	Target Neighborhood Hits	332	Shared Neighborhood Hits	109
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CRKL_HUMAN
NC score	0.332664 (rank : 51)	θ value	0.0193708 (rank : 41)
Query Neighborhood Hits	128	Target Neighborhood Hits	313	Shared Neighborhood Hits	110
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ARHG6_MOUSE
NC score	0.326465 (rank : 52)	θ value	0.0431538 (rank : 49)
Query Neighborhood Hits	128	Target Neighborhood Hits	394	Shared Neighborhood Hits	111
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG6_HUMAN
NC score	0.324343 (rank : 53)	θ value	0.0431538 (rank : 48)
Query Neighborhood Hits	128	Target Neighborhood Hits	376	Shared Neighborhood Hits	110
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ABI1_MOUSE
NC score	0.320432 (rank : 54)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	128	Target Neighborhood Hits	246	Shared Neighborhood Hits	110
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SNX18_MOUSE
NC score	0.314549 (rank : 55)	θ value	0.0193708 (rank : 43)
Query Neighborhood Hits	128	Target Neighborhood Hits	198	Shared Neighborhood Hits	91
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SRBS1_MOUSE
NC score	0.314465 (rank : 56)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	128	Target Neighborhood Hits	409	Shared Neighborhood Hits	112
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CRK_MOUSE
NC score	0.314190 (rank : 57)	θ value	0.365318 (rank : 72)
Query Neighborhood Hits	128	Target Neighborhood Hits	314	Shared Neighborhood Hits	109
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SRBS1_HUMAN
NC score	0.310667 (rank : 58)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	128	Target Neighborhood Hits	396	Shared Neighborhood Hits	113
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SNX18_HUMAN
NC score	0.309843 (rank : 59)	θ value	0.0193708 (rank : 42)
Query Neighborhood Hits	128	Target Neighborhood Hits	207	Shared Neighborhood Hits	93
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CRK_HUMAN
NC score	0.307759 (rank : 60)	θ value	0.365318 (rank : 71)
Query Neighborhood Hits	128	Target Neighborhood Hits	308	Shared Neighborhood Hits	110
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DNMBP_HUMAN
NC score	0.307696 (rank : 61)	θ value	0.125558 (rank : 58)
Query Neighborhood Hits	128	Target Neighborhood Hits	413	Shared Neighborhood Hits	110
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCF2_HUMAN
NC score	0.303062 (rank : 62)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	128	Target Neighborhood Hits	229	Shared Neighborhood Hits	99
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

STAM1_MOUSE
NC score	0.303048 (rank : 63)	θ value	0.47712 (rank : 80)
Query Neighborhood Hits	128	Target Neighborhood Hits	273	Shared Neighborhood Hits	108
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NEBU_HUMAN
NC score	0.302034 (rank : 64)	θ value	0.00869519 (rank : 32)
Query Neighborhood Hits	128	Target Neighborhood Hits	420	Shared Neighborhood Hits	108
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

STAM1_HUMAN
NC score	0.301895 (rank : 65)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	128	Target Neighborhood Hits	271	Shared Neighborhood Hits	110
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI1_HUMAN
NC score	0.301198 (rank : 66)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	128	Target Neighborhood Hits	257	Shared Neighborhood Hits	109
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

DNMBP_MOUSE
NC score	0.298320 (rank : 67)	θ value	0.163984 (rank : 61)
Query Neighborhood Hits	128	Target Neighborhood Hits	435	Shared Neighborhood Hits	113
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DBNL_HUMAN
NC score	0.291048 (rank : 68)	θ value	4.03905 (rank : 108)
Query Neighborhood Hits	128	Target Neighborhood Hits	244	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

VAV_HUMAN
NC score	0.290452 (rank : 69)	θ value	0.00869519 (rank : 33)
Query Neighborhood Hits	128	Target Neighborhood Hits	452	Shared Neighborhood Hits	110
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

DBNL_MOUSE
NC score	0.290161 (rank : 70)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	128	Target Neighborhood Hits	306	Shared Neighborhood Hits	104
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

CRKL_MOUSE
NC score	0.289353 (rank : 71)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	128	Target Neighborhood Hits	307	Shared Neighborhood Hits	105
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

VAV_MOUSE
NC score	0.285690 (rank : 72)	θ value	0.0252991 (rank : 46)
Query Neighborhood Hits	128	Target Neighborhood Hits	430	Shared Neighborhood Hits	112
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

NPHP1_MOUSE
NC score	0.277876 (rank : 73)	θ value	0.365318 (rank : 75)
Query Neighborhood Hits	128	Target Neighborhood Hits	267	Shared Neighborhood Hits	105
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STAM2_MOUSE
NC score	0.275113 (rank : 74)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	128	Target Neighborhood Hits	285	Shared Neighborhood Hits	104
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ITSN2_HUMAN
NC score	0.265298 (rank : 75)	θ value	0.000786445 (rank : 19)
Query Neighborhood Hits	128	Target Neighborhood Hits	1173	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

STAM2_HUMAN
NC score	0.260719 (rank : 76)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	128	Target Neighborhood Hits	288	Shared Neighborhood Hits	107
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAC_HUMAN
NC score	0.255055 (rank : 77)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	128	Target Neighborhood Hits	276	Shared Neighborhood Hits	102
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI3_HUMAN
NC score	0.252921 (rank : 78)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	93
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ITSN2_MOUSE
NC score	0.249175 (rank : 79)	θ value	0.0252991 (rank : 45)
Query Neighborhood Hits	128	Target Neighborhood Hits	1371	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NCF1_HUMAN
NC score	0.248910 (rank : 80)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	128	Target Neighborhood Hits	198	Shared Neighborhood Hits	90
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ABI3_MOUSE
NC score	0.246606 (rank : 81)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ITSN1_HUMAN
NC score	0.246004 (rank : 82)	θ value	0.00869519 (rank : 31)
Query Neighborhood Hits	128	Target Neighborhood Hits	1757	Shared Neighborhood Hits	119
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.245628 (rank : 83)	θ value	0.0148317 (rank : 38)
Query Neighborhood Hits	128	Target Neighborhood Hits	1669	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

STAC_MOUSE
NC score	0.245549 (rank : 84)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	128	Target Neighborhood Hits	268	Shared Neighborhood Hits	104
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

OSTF1_HUMAN
NC score	0.244198 (rank : 85)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	128	Target Neighborhood Hits	466	Shared Neighborhood Hits	112
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.243188 (rank : 86)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	128	Target Neighborhood Hits	467	Shared Neighborhood Hits	113
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

NCF1_MOUSE
NC score	0.242033 (rank : 87)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	128	Target Neighborhood Hits	198	Shared Neighborhood Hits	95
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

VAV2_HUMAN
NC score	0.233054 (rank : 88)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	128	Target Neighborhood Hits	453	Shared Neighborhood Hits	109
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

IASPP_HUMAN
NC score	0.233032 (rank : 89)	θ value	0.0961366 (rank : 56)
Query Neighborhood Hits	128	Target Neighborhood Hits	688	Shared Neighborhood Hits	97
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

VAV2_MOUSE
NC score	0.232668 (rank : 90)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	128	Target Neighborhood Hits	456	Shared Neighborhood Hits	109
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.232392 (rank : 91)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	128	Target Neighborhood Hits	404	Shared Neighborhood Hits	106
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.231416 (rank : 92)	θ value	2.36792 (rank : 100)
Query Neighborhood Hits	128	Target Neighborhood Hits	398	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

AHI1_HUMAN
NC score	0.226217 (rank : 93)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	128	Target Neighborhood Hits	537	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

IASPP_MOUSE
NC score	0.224568 (rank : 94)	θ value	0.0148317 (rank : 37)
Query Neighborhood Hits	128	Target Neighborhood Hits	1024	Shared Neighborhood Hits	102
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

AHI1_MOUSE
NC score	0.222405 (rank : 95)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	128	Target Neighborhood Hits	496	Shared Neighborhood Hits	112
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

RHG26_HUMAN
NC score	0.220001 (rank : 96)	θ value	0.00134147 (rank : 21)
Query Neighborhood Hits	128	Target Neighborhood Hits	281	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

NPHP1_HUMAN
NC score	0.218929 (rank : 97)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	128	Target Neighborhood Hits	288	Shared Neighborhood Hits	96
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ARHG4_HUMAN
NC score	0.215134 (rank : 98)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	128	Target Neighborhood Hits	242	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

STAC3_MOUSE
NC score	0.211133 (rank : 99)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	128	Target Neighborhood Hits	232	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.209833 (rank : 100)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	128	Target Neighborhood Hits	228	Shared Neighborhood Hits	90
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG9_HUMAN
NC score	0.208285 (rank : 101)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	128	Target Neighborhood Hits	235	Shared Neighborhood Hits	96
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.207711 (rank : 102)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	128	Target Neighborhood Hits	234	Shared Neighborhood Hits	96
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ASPP1_HUMAN
NC score	0.191241 (rank : 103)	θ value	0.47712 (rank : 77)
Query Neighborhood Hits	128	Target Neighborhood Hits	956	Shared Neighborhood Hits	100
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PLCG1_MOUSE
NC score	0.191098 (rank : 104)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	128	Target Neighborhood Hits	314	Shared Neighborhood Hits	99
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
NC score	0.190303 (rank : 105)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	128	Target Neighborhood Hits	280	Shared Neighborhood Hits	93
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_HUMAN
NC score	0.185220 (rank : 106)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	128	Target Neighborhood Hits	293	Shared Neighborhood Hits	95
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RUSC1_HUMAN
NC score	0.182852 (rank : 107)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	128	Target Neighborhood Hits	226	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SNX9_MOUSE
NC score	0.179144 (rank : 108)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	128	Target Neighborhood Hits	141	Shared Neighborhood Hits	65
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

ASPP1_MOUSE
NC score	0.175328 (rank : 109)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	128	Target Neighborhood Hits	1244	Shared Neighborhood Hits	103
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SNX9_HUMAN
NC score	0.175125 (rank : 110)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	128	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

RIMB2_HUMAN
NC score	0.172245 (rank : 111)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	128	Target Neighborhood Hits	263	Shared Neighborhood Hits	83
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

NOXO1_MOUSE
NC score	0.168877 (rank : 112)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	128	Target Neighborhood Hits	114	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

RIMB2_MOUSE
NC score	0.162829 (rank : 113)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	128	Target Neighborhood Hits	246	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_MOUSE
NC score	0.162204 (rank : 114)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	128	Target Neighborhood Hits	206	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

STS1_MOUSE
NC score	0.160970 (rank : 115)	θ value	0.365318 (rank : 76)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ARHG4_MOUSE
NC score	0.158742 (rank : 116)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	128	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

STS1_HUMAN
NC score	0.158550 (rank : 117)	θ value	0.47712 (rank : 81)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

RHG04_HUMAN
NC score	0.148656 (rank : 118)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	128	Target Neighborhood Hits	307	Shared Neighborhood Hits	98
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ES8L3_MOUSE
NC score	0.148139 (rank : 119)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	128	Target Neighborhood Hits	168	Shared Neighborhood Hits	85
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ANM2_HUMAN
NC score	0.140636 (rank : 120)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	128	Target Neighborhood Hits	175	Shared Neighborhood Hits	86
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SLAP2_HUMAN
NC score	0.140433 (rank : 121)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	128	Target Neighborhood Hits	139	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

ASPP2_HUMAN
NC score	0.138862 (rank : 122)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	128	Target Neighborhood Hits	1156	Shared Neighborhood Hits	96
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SLAP2_MOUSE
NC score	0.137905 (rank : 123)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	128	Target Neighborhood Hits	136	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

STS2_HUMAN
NC score	0.135459 (rank : 124)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	128	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

DDEF1_MOUSE
NC score	0.135375 (rank : 125)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	128	Target Neighborhood Hits	592	Shared Neighborhood Hits	97
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

SHLB1_MOUSE
NC score	0.134277 (rank : 126)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	128	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SPN90_HUMAN
NC score	0.133835 (rank : 127)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ANM2_MOUSE
NC score	0.132148 (rank : 128)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	128	Target Neighborhood Hits	175	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

P85A_HUMAN
NC score	0.131113 (rank : 129)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	128	Target Neighborhood Hits	479	Shared Neighborhood Hits	70
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MYO1F_HUMAN
NC score	0.129980 (rank : 130)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	128	Target Neighborhood Hits	275	Shared Neighborhood Hits	105
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.129635 (rank : 131)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	128	Target Neighborhood Hits	262	Shared Neighborhood Hits	104
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

P85A_MOUSE
NC score	0.129603 (rank : 132)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	128	Target Neighborhood Hits	435	Shared Neighborhood Hits	74
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SPTA2_HUMAN
NC score	0.127142 (rank : 133)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	128	Target Neighborhood Hits	888	Shared Neighborhood Hits	103
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SLAP1_HUMAN
NC score	0.126207 (rank : 134)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SHLB1_HUMAN
NC score	0.125872 (rank : 135)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	128	Target Neighborhood Hits	96	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SRGP2_MOUSE
NC score	0.125124 (rank : 136)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	128	Target Neighborhood Hits	324	Shared Neighborhood Hits	92
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SLAP1_MOUSE
NC score	0.125022 (rank : 137)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	128	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SPTA1_HUMAN
NC score	0.124114 (rank : 138)	θ value	0.47712 (rank : 78)
Query Neighborhood Hits	128	Target Neighborhood Hits	748	Shared Neighborhood Hits	101
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRGP2_HUMAN
NC score	0.123663 (rank : 139)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	128	Target Neighborhood Hits	331	Shared Neighborhood Hits	91
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ES8L2_HUMAN
NC score	0.121873 (rank : 140)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	128	Target Neighborhood Hits	193	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MYO1E_HUMAN
NC score	0.121727 (rank : 141)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	128	Target Neighborhood Hits	293	Shared Neighborhood Hits	109
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

DDEF2_HUMAN
NC score	0.120049 (rank : 142)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	128	Target Neighborhood Hits	599	Shared Neighborhood Hits	93
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EPS8_MOUSE
NC score	0.119583 (rank : 143)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

SRC_HUMAN
NC score	0.119189 (rank : 144)	θ value	0.163984 (rank : 65)
Query Neighborhood Hits	128	Target Neighborhood Hits	1058	Shared Neighborhood Hits	112
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_MOUSE
NC score	0.118526 (rank : 145)	θ value	0.365318 (rank : 74)
Query Neighborhood Hits	128	Target Neighborhood Hits	1073	Shared Neighborhood Hits	112
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SPTA1_MOUSE
NC score	0.118390 (rank : 146)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	128	Target Neighborhood Hits	675	Shared Neighborhood Hits	98
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CIP4_HUMAN
NC score	0.116787 (rank : 147)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	128	Target Neighborhood Hits	374	Shared Neighborhood Hits	48
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

FYN_HUMAN
NC score	0.116662 (rank : 148)	θ value	0.365318 (rank : 73)
Query Neighborhood Hits	128	Target Neighborhood Hits	1078	Shared Neighborhood Hits	112
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

DDEF2_MOUSE
NC score	0.116151 (rank : 149)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	128	Target Neighborhood Hits	625	Shared Neighborhood Hits	93
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ES8L3_HUMAN
NC score	0.115843 (rank : 150)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	128	Target Neighborhood Hits	206	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L2_MOUSE
NC score	0.115780 (rank : 151)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	128	Target Neighborhood Hits	169	Shared Neighborhood Hits	72
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FGR_HUMAN
NC score	0.115228 (rank : 152)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	128	Target Neighborhood Hits	1067	Shared Neighborhood Hits	107
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRGP1_HUMAN
NC score	0.112626 (rank : 153)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	128	Target Neighborhood Hits	390	Shared Neighborhood Hits	91
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRC_MOUSE
NC score	0.112513 (rank : 154)	θ value	0.0148317 (rank : 40)
Query Neighborhood Hits	128	Target Neighborhood Hits	1033	Shared Neighborhood Hits	104
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HCK_HUMAN
NC score	0.112010 (rank : 155)	θ value	0.0113563 (rank : 34)
Query Neighborhood Hits	128	Target Neighborhood Hits	1035	Shared Neighborhood Hits	104
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SPN90_MOUSE
NC score	0.111746 (rank : 156)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SHLB2_MOUSE
NC score	0.111740 (rank : 157)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	128	Target Neighborhood Hits	88	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

RASA1_HUMAN
NC score	0.111733 (rank : 158)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	128	Target Neighborhood Hits	258	Shared Neighborhood Hits	43
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SHLB2_HUMAN
NC score	0.111479 (rank : 159)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	128	Target Neighborhood Hits	86	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

NOXO1_HUMAN
NC score	0.110757 (rank : 160)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	128	Target Neighborhood Hits	100	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

FNBP2_HUMAN
NC score	0.110655 (rank : 161)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	128	Target Neighborhood Hits	432	Shared Neighborhood Hits	94
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

HCK_MOUSE
NC score	0.110653 (rank : 162)	θ value	0.0252991 (rank : 44)
Query Neighborhood Hits	128	Target Neighborhood Hits	1029	Shared Neighborhood Hits	105
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

EPS8_HUMAN
NC score	0.110513 (rank : 163)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	128	Target Neighborhood Hits	151	Shared Neighborhood Hits	70
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

M3KL4_HUMAN
NC score	0.109652 (rank : 164)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	128	Target Neighborhood Hits	1087	Shared Neighborhood Hits	108
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

YES_MOUSE
NC score	0.109351 (rank : 165)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	128	Target Neighborhood Hits	1052	Shared Neighborhood Hits	109
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.108254 (rank : 166)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	128	Target Neighborhood Hits	1059	Shared Neighborhood Hits	109
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
NC score	0.107209 (rank : 167)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	128	Target Neighborhood Hits	1069	Shared Neighborhood Hits	107
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

PPIP2_HUMAN
NC score	0.104919 (rank : 168)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	128	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

ARHG5_HUMAN
NC score	0.104234 (rank : 169)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	128	Target Neighborhood Hits	172	Shared Neighborhood Hits	59
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

SH21B_MOUSE
NC score	0.103192 (rank : 170)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	128	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ES8L1_HUMAN
NC score	0.102796 (rank : 171)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	128	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

P85B_HUMAN
NC score	0.101205 (rank : 172)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	128	Target Neighborhood Hits	543	Shared Neighborhood Hits	56
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TCGAP_MOUSE
NC score	0.100215 (rank : 173)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	128	Target Neighborhood Hits	409	Shared Neighborhood Hits	79
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CSK_MOUSE
NC score	0.098921 (rank : 174)	θ value	0.0148317 (rank : 36)
Query Neighborhood Hits	128	Target Neighborhood Hits	1009	Shared Neighborhood Hits	91
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

M3K11_HUMAN
NC score	0.098776 (rank : 175)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	128	Target Neighborhood Hits	1136	Shared Neighborhood Hits	108
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

CSK_HUMAN
NC score	0.098577 (rank : 176)	θ value	0.0148317 (rank : 35)
Query Neighborhood Hits	128	Target Neighborhood Hits	1009	Shared Neighborhood Hits	91
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

PTK6_HUMAN
NC score	0.098410 (rank : 177)	θ value	0.00665767 (rank : 28)
Query Neighborhood Hits	128	Target Neighborhood Hits	1020	Shared Neighborhood Hits	98
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

P85B_MOUSE
NC score	0.098094 (rank : 178)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	128	Target Neighborhood Hits	519	Shared Neighborhood Hits	52
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SH21B_HUMAN
NC score	0.097987 (rank : 179)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	128	Target Neighborhood Hits	101	Shared Neighborhood Hits	23
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PKHG1_HUMAN
NC score	0.097728 (rank : 180)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	128	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

M3K9_HUMAN
NC score	0.097126 (rank : 181)	θ value	0.0736092 (rank : 53)
Query Neighborhood Hits	128	Target Neighborhood Hits	1123	Shared Neighborhood Hits	107
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

RIMB1_HUMAN
NC score	0.096557 (rank : 182)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	128	Target Neighborhood Hits	1479	Shared Neighborhood Hits	95
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

LYN_MOUSE
NC score	0.096176 (rank : 183)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	128	Target Neighborhood Hits	1023	Shared Neighborhood Hits	90
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PTK6_MOUSE
NC score	0.096037 (rank : 184)	θ value	0.0431538 (rank : 50)
Query Neighborhood Hits	128	Target Neighborhood Hits	1026	Shared Neighborhood Hits	94
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SHAN2_MOUSE
NC score	0.096016 (rank : 185)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	128	Target Neighborhood Hits	446	Shared Neighborhood Hits	69
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

M3K10_HUMAN
NC score	0.095905 (rank : 186)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	128	Target Neighborhood Hits	1071	Shared Neighborhood Hits	106
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

FRK_HUMAN
NC score	0.094500 (rank : 187)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	128	Target Neighborhood Hits	1058	Shared Neighborhood Hits	107
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LYN_HUMAN
NC score	0.093275 (rank : 188)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	128	Target Neighborhood Hits	1022	Shared Neighborhood Hits	93
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ES8L1_MOUSE
NC score	0.093268 (rank : 189)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	128	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

TCGAP_HUMAN
NC score	0.093072 (rank : 190)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	128	Target Neighborhood Hits	872	Shared Neighborhood Hits	85
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BTK_HUMAN
NC score	0.092574 (rank : 191)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	128	Target Neighborhood Hits	1026	Shared Neighborhood Hits	107
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

PPIP2_MOUSE
NC score	0.091670 (rank : 192)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	128	Target Neighborhood Hits	308	Shared Neighborhood Hits	15
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

RIMB1_MOUSE
NC score	0.090052 (rank : 193)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	128	Target Neighborhood Hits	1376	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

NGEF_MOUSE
NC score	0.090034 (rank : 194)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	128	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_MOUSE
NC score	0.089484 (rank : 195)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	128	Target Neighborhood Hits	152	Shared Neighborhood Hits	38
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

TIAM1_MOUSE
NC score	0.089073 (rank : 196)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	128	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

MCF2L_MOUSE
NC score	0.088749 (rank : 197)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	128	Target Neighborhood Hits	255	Shared Neighborhood Hits	36
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

DAPP1_HUMAN
NC score	0.088369 (rank : 198)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ARHG3_MOUSE
NC score	0.088363 (rank : 199)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	128	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.088115 (rank : 200)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	128	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

PREX1_HUMAN
NC score	0.087852 (rank : 201)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	128	Target Neighborhood Hits	177	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

BI2L1_HUMAN
NC score	0.087300 (rank : 202)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	128	Target Neighborhood Hits	156	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BTK_MOUSE
NC score	0.087294 (rank : 203)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	128	Target Neighborhood Hits	1017	Shared Neighborhood Hits	98
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

TIAM1_HUMAN
NC score	0.087213 (rank : 204)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	128	Target Neighborhood Hits	225	Shared Neighborhood Hits	20
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

BLK_HUMAN
NC score	0.087018 (rank : 205)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	128	Target Neighborhood Hits	994	Shared Neighborhood Hits	85
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

P55G_HUMAN
NC score	0.086615 (rank : 206)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	128	Target Neighborhood Hits	451	Shared Neighborhood Hits	38
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

DAPP1_MOUSE
NC score	0.086431 (rank : 207)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	128	Target Neighborhood Hits	225	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ARHG8_MOUSE
NC score	0.085819 (rank : 208)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	128	Target Neighborhood Hits	79	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

DOCK1_HUMAN
NC score	0.085818 (rank : 209)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	128	Target Neighborhood Hits	191	Shared Neighborhood Hits	76
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

NGEF_HUMAN
NC score	0.085782 (rank : 210)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	128	Target Neighborhood Hits	166	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

BLK_MOUSE
NC score	0.084937 (rank : 211)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	128	Target Neighborhood Hits	992	Shared Neighborhood Hits	77
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

APS_HUMAN
NC score	0.083607 (rank : 212)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	128	Target Neighborhood Hits	162	Shared Neighborhood Hits	31
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

LCK_HUMAN
NC score	0.083520 (rank : 213)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	128	Target Neighborhood Hits	987	Shared Neighborhood Hits	73
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BIN1_HUMAN
NC score	0.083255 (rank : 214)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	128	Target Neighborhood Hits	335	Shared Neighborhood Hits	53
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

LCK_MOUSE
NC score	0.082553 (rank : 215)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	128	Target Neighborhood Hits	981	Shared Neighborhood Hits	73
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

P55G_MOUSE
NC score	0.082335 (rank : 216)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	128	Target Neighborhood Hits	401	Shared Neighborhood Hits	36
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

GRB14_MOUSE
NC score	0.081161 (rank : 217)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	128	Target Neighborhood Hits	149	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHB_MOUSE
NC score	0.081084 (rank : 218)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	128	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

BIN1_MOUSE
NC score	0.081019 (rank : 219)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	128	Target Neighborhood Hits	283	Shared Neighborhood Hits	54
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

ABL1_MOUSE
NC score	0.080960 (rank : 220)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	128	Target Neighborhood Hits	1178	Shared Neighborhood Hits	84
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_HUMAN
NC score	0.080513 (rank : 221)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	128	Target Neighborhood Hits	1220	Shared Neighborhood Hits	85
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

AMPH_HUMAN
NC score	0.080378 (rank : 222)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	128	Target Neighborhood Hits	455	Shared Neighborhood Hits	58
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

GRB14_HUMAN
NC score	0.079745 (rank : 223)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	128	Target Neighborhood Hits	137	Shared Neighborhood Hits	30
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SRMS_MOUSE
NC score	0.079211 (rank : 224)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	128	Target Neighborhood Hits	964	Shared Neighborhood Hits	71
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SHB_HUMAN
NC score	0.078545 (rank : 225)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	128	Target Neighborhood Hits	141	Shared Neighborhood Hits	31
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHE_MOUSE
NC score	0.078410 (rank : 226)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	128	Target Neighborhood Hits	169	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ARHG8_HUMAN
NC score	0.078265 (rank : 227)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	128	Target Neighborhood Hits	85	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SHC1_HUMAN
NC score	0.078098 (rank : 228)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	128	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHD_MOUSE
NC score	0.078042 (rank : 229)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	128	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC3_MOUSE
NC score	0.077531 (rank : 230)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	128	Target Neighborhood Hits	151	Shared Neighborhood Hits	31
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

TXK_MOUSE
NC score	0.077046 (rank : 231)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	128	Target Neighborhood Hits	980	Shared Neighborhood Hits	82
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ARHGG_HUMAN
NC score	0.076904 (rank : 232)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	128	Target Neighborhood Hits	129	Shared Neighborhood Hits	32
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

HSH2D_HUMAN
NC score	0.076826 (rank : 233)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	128	Target Neighborhood Hits	159	Shared Neighborhood Hits	25
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

BI2L1_MOUSE
NC score	0.076652 (rank : 234)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	128	Target Neighborhood Hits	197	Shared Neighborhood Hits	40
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SHC1_MOUSE
NC score	0.076370 (rank : 235)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	128	Target Neighborhood Hits	180	Shared Neighborhood Hits	32
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ABL2_HUMAN
NC score	0.076366 (rank : 236)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	128	Target Neighborhood Hits	1045	Shared Neighborhood Hits	72
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

SHD_HUMAN
NC score	0.076188 (rank : 237)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	128	Target Neighborhood Hits	204	Shared Neighborhood Hits	29
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
NC score	0.075642 (rank : 238)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	128	Target Neighborhood Hits	164	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ARHGA_MOUSE
NC score	0.075395 (rank : 239)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	128	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

GRB7_MOUSE
NC score	0.075378 (rank : 240)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

SHAN1_HUMAN
NC score	0.075124 (rank : 241)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	128	Target Neighborhood Hits	1041	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

TEC_HUMAN
NC score	0.074977 (rank : 242)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	128	Target Neighborhood Hits	1006	Shared Neighborhood Hits	82
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SHC2_HUMAN
NC score	0.074729 (rank : 243)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	128	Target Neighborhood Hits	170	Shared Neighborhood Hits	31
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
NC score	0.074537 (rank : 244)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	128	Target Neighborhood Hits	144	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

TEC_MOUSE
NC score	0.074242 (rank : 245)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	128	Target Neighborhood Hits	1006	Shared Neighborhood Hits	84
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MCF2_HUMAN
NC score	0.074100 (rank : 246)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	128	Target Neighborhood Hits	166	Shared Neighborhood Hits	21
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

PELP1_MOUSE
NC score	0.074050 (rank : 247)	θ value	0.163984 (rank : 63)
Query Neighborhood Hits	128	Target Neighborhood Hits	709	Shared Neighborhood Hits	17
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

LNK_MOUSE
NC score	0.073746 (rank : 248)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	128	Target Neighborhood Hits	132	Shared Neighborhood Hits	27
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_HUMAN
NC score	0.073576 (rank : 249)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	128	Target Neighborhood Hits	151	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

AMPH_MOUSE
NC score	0.073252 (rank : 250)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	128	Target Neighborhood Hits	291	Shared Neighborhood Hits	54
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

TXK_HUMAN
NC score	0.072413 (rank : 251)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	128	Target Neighborhood Hits	971	Shared Neighborhood Hits	75
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ARHGA_HUMAN
NC score	0.072307 (rank : 252)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	128	Target Neighborhood Hits	187	Shared Neighborhood Hits	18
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

RUSC2_HUMAN
NC score	0.069254 (rank : 253)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	128	Target Neighborhood Hits	205	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ITK_HUMAN
NC score	0.069178 (rank : 254)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	128	Target Neighborhood Hits	1016	Shared Neighborhood Hits	83
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SLY_MOUSE
NC score	0.068915 (rank : 255)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	128	Target Neighborhood Hits	108	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SHC3_HUMAN
NC score	0.068558 (rank : 256)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	128	Target Neighborhood Hits	155	Shared Neighborhood Hits	29
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

ECT2_MOUSE
NC score	0.068526 (rank : 257)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	128	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

BAIP2_MOUSE
NC score	0.068132 (rank : 258)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	128	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

GRB7_HUMAN
NC score	0.067520 (rank : 259)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	128	Target Neighborhood Hits	156	Shared Neighborhood Hits	29
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

HAPIP_HUMAN
NC score	0.066090 (rank : 260)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	128	Target Neighborhood Hits	350	Shared Neighborhood Hits	22
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

BAIP2_HUMAN
NC score	0.065975 (rank : 261)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	128	Target Neighborhood Hits	192	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

ECT2_HUMAN
NC score	0.065559 (rank : 262)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	128	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SRMS_HUMAN
NC score	0.065468 (rank : 263)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	128	Target Neighborhood Hits	946	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

ITK_MOUSE
NC score	0.064894 (rank : 264)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	128	Target Neighborhood Hits	985	Shared Neighborhood Hits	72
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

NRAP_MOUSE
NC score	0.064363 (rank : 265)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	128	Target Neighborhood Hits	167	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

MATK_MOUSE
NC score	0.064236 (rank : 266)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	128	Target Neighborhood Hits	952	Shared Neighborhood Hits	54
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

APS_MOUSE
NC score	0.064219 (rank : 267)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	128	Target Neighborhood Hits	134	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SH24A_HUMAN
NC score	0.064125 (rank : 268)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	128	Target Neighborhood Hits	455	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH21A_HUMAN
NC score	0.064111 (rank : 269)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	128	Target Neighborhood Hits	89	Shared Neighborhood Hits	19
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

MATK_HUMAN
NC score	0.064109 (rank : 270)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	128	Target Neighborhood Hits	954	Shared Neighborhood Hits	51
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

NRAP_HUMAN
NC score	0.063942 (rank : 271)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	128	Target Neighborhood Hits	159	Shared Neighborhood Hits	6
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

GRB10_MOUSE
NC score	0.063819 (rank : 272)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	128	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB10_HUMAN
NC score	0.063320 (rank : 273)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	128	Target Neighborhood Hits	147	Shared Neighborhood Hits	30
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

SH21A_MOUSE
NC score	0.062922 (rank : 274)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	128	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SLY_HUMAN
NC score	0.060739 (rank : 275)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	128	Target Neighborhood Hits	81	Shared Neighborhood Hits	36
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

BCAR3_HUMAN
NC score	0.060530 (rank : 276)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	128	Target Neighborhood Hits	129	Shared Neighborhood Hits	27
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
NC score	0.059979 (rank : 277)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	128	Target Neighborhood Hits	127	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

SH2D3_MOUSE
NC score	0.057769 (rank : 278)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	128	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

RUSC2_MOUSE
NC score	0.057705 (rank : 279)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	128	Target Neighborhood Hits	305	Shared Neighborhood Hits	45
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ARHGC_HUMAN
NC score	0.057304 (rank : 280)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	128	Target Neighborhood Hits	351	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_HUMAN
NC score	0.056779 (rank : 281)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	128	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

SH23A_HUMAN
NC score	0.056573 (rank : 282)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	128	Target Neighborhood Hits	149	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

LCP2_MOUSE
NC score	0.056527 (rank : 283)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	128	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SH22A_MOUSE
NC score	0.056518 (rank : 284)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	128	Target Neighborhood Hits	179	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

LBC_HUMAN
NC score	0.056299 (rank : 285)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	128	Target Neighborhood Hits	90	Shared Neighborhood Hits	16
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHGC_MOUSE
NC score	0.056241 (rank : 286)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	128	Target Neighborhood Hits	344	Shared Neighborhood Hits	19
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SH2D3_HUMAN
NC score	0.055946 (rank : 287)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	128	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

FGD2_HUMAN
NC score	0.055807 (rank : 288)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	128	Target Neighborhood Hits	151	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ARHGB_HUMAN
NC score	0.055067 (rank : 289)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	128	Target Neighborhood Hits	375	Shared Neighborhood Hits	20
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FGD4_HUMAN
NC score	0.054987 (rank : 290)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	128	Target Neighborhood Hits	219	Shared Neighborhood Hits	19
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

EM55_HUMAN
NC score	0.054823 (rank : 291)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	128	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

FGD4_MOUSE
NC score	0.054707 (rank : 292)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ARHGF_HUMAN
NC score	0.054009 (rank : 293)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	128	Target Neighborhood Hits	214	Shared Neighborhood Hits	22
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

GNRP_MOUSE
NC score	0.053685 (rank : 294)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	128	Target Neighborhood Hits	191	Shared Neighborhood Hits	17
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FER_HUMAN
NC score	0.053297 (rank : 295)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	128	Target Neighborhood Hits	1278	Shared Neighborhood Hits	47
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGD3_MOUSE
NC score	0.053189 (rank : 296)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	128	Target Neighborhood Hits	257	Shared Neighborhood Hits	18
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

EM55_MOUSE
NC score	0.052983 (rank : 297)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	128	Target Neighborhood Hits	221	Shared Neighborhood Hits	51
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

PTN11_MOUSE
NC score	0.052884 (rank : 298)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

SOCS7_MOUSE
NC score	0.052880 (rank : 299)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	128	Target Neighborhood Hits	154	Shared Neighborhood Hits	29
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

PTN11_HUMAN
NC score	0.052877 (rank : 300)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	128	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

ARHG1_MOUSE
NC score	0.052637 (rank : 301)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	128	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

HSH2D_MOUSE
NC score	0.051981 (rank : 302)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	128	Target Neighborhood Hits	124	Shared Neighborhood Hits	19
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

MPP6_HUMAN
NC score	0.051453 (rank : 303)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	128	Target Neighborhood Hits	180	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

FGD1_HUMAN
NC score	0.051451 (rank : 304)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	128	Target Neighborhood Hits	367	Shared Neighborhood Hits	28
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GNRP_HUMAN
NC score	0.051409 (rank : 305)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	128	Target Neighborhood Hits	239	Shared Neighborhood Hits	16
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHG4_HUMAN
NC score	0.050842 (rank : 306)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	128	Target Neighborhood Hits	200	Shared Neighborhood Hits	15
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

FGD2_MOUSE
NC score	0.050840 (rank : 307)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	128	Target Neighborhood Hits	163	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

BCR_HUMAN
NC score	0.050640 (rank : 308)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	128	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RGNEF_MOUSE
NC score	0.050398 (rank : 309)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	128	Target Neighborhood Hits	641	Shared Neighborhood Hits	23
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

TRIO_HUMAN
NC score	0.044364 (rank : 310)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	128	Target Neighborhood Hits	1580	Shared Neighborhood Hits	62
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PRRT3_HUMAN
NC score	0.041637 (rank : 311)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	128	Target Neighborhood Hits	998	Shared Neighborhood Hits	25
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CSKP_MOUSE
NC score	0.038678 (rank : 312)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	128	Target Neighborhood Hits	1027	Shared Neighborhood Hits	72
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSKP_HUMAN
NC score	0.038389 (rank : 313)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	128	Target Neighborhood Hits	1022	Shared Neighborhood Hits	67
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKI2_HUMAN
NC score	0.032726 (rank : 314)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	128	Target Neighborhood Hits	747	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPN1_MOUSE
NC score	0.031695 (rank : 315)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	128	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

DLG5_HUMAN
NC score	0.029565 (rank : 316)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	128	Target Neighborhood Hits	1088	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

EPN1_HUMAN
NC score	0.026277 (rank : 317)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	128	Target Neighborhood Hits	206	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

PCLO_MOUSE
NC score	0.024511 (rank : 318)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	128	Target Neighborhood Hits	2275	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RGS3_MOUSE
NC score	0.021811 (rank : 319)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	128	Target Neighborhood Hits	1621	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CBX2_HUMAN
NC score	0.021678 (rank : 320)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	128	Target Neighborhood Hits	264	Shared Neighborhood Hits	8
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

CCD71_HUMAN
NC score	0.018412 (rank : 321)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	128	Target Neighborhood Hits	55	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IV32, Q6IPE2, Q9H8H4, Q9H9F1	Gene names	CCDC71
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 71.

MILK1_MOUSE
NC score	0.015977 (rank : 322)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	128	Target Neighborhood Hits	788	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

TRAF7_HUMAN
NC score	0.012922 (rank : 323)	θ value	2.36792 (rank : 99)
Query Neighborhood Hits	128	Target Neighborhood Hits	482	Shared Neighborhood Hits	5
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

GLIS1_HUMAN
NC score	-0.001931 (rank : 324)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	128	Target Neighborhood Hits	748	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

ZN142_HUMAN
NC score	-0.001977 (rank : 325)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	128	Target Neighborhood Hits	1007	Shared Neighborhood Hits	9
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).